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https://www.readbyqxmd.com/read/28104319/the-mexican-consensus-on-probiotics-in-gastroenterology
#1
M A Valdovinos, E Montijo, A T Abreu, S Heller, A González-Garay, D Bacarreza, M Bielsa-Fernández, M C Bojórquez-Ramos, F Bosques-Padilla, A I Burguete-García, R Carmona-Sánchez, A Consuelo-Sánchez, E Coss-Adame, J A Chávez-Barrera, M de Ariño, J Flores-Calderón, O Gómez-Escudero, M S González-Huezo, M E Icaza-Chávez, A Larrosa-Haro, M Morales-Arámbula, C Murata, J A Ramírez-Mayans, J M Remes-Troche, T Rizo-Robles, M Peláez-Luna, E M Toro-Monjaraz, A Torre, M E Urquidi-Rivera, R Vázquez, J K Yamamoto-Furusho, F Guarner
INTRODUCTION: Probiotics are frequently prescribed in clinical practice. Their efficacy in treating gastrointestinal disorders is supported by a significant number of clinical trials. However, the correct prescription of these agents is hampered due to a lack of knowledge of the scientific evidence and to the different presentations and microbial compositions of the probiotics that are currently available. AIM: To provide the clinician with a consensus review of probiotics and recommendations for their use in gastroenterology...
January 16, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28092152/issues-in-nutrition-dietary-considerations-in-select-chronic-conditions
#2
Margaret E Thompson, Mary Barth Noel
Chronic diseases that affect the gastrointestinal tract also tend to affect nutrition. The incidence of chronic liver disease is increasing. As the prevalence of obesity rises, so do the incidences of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Patients with chronic liver disease usually have some degree of malnutrition. In the absence of encephalopathy, patients with chronic liver disease should consume more protein than that in the average diet. There is some controversy about whether diet plays a role in the development of inflammatory bowel disease...
January 2017: FP Essentials
https://www.readbyqxmd.com/read/28077249/altered-mucosal-expression-of-micrornas-in-pediatric-patients-with-inflammatory-bowel-disease
#3
Nóra Judit Béres, Zoltán Kiss, Zsófia Sztupinszki, Gábor Lendvai, András Arató, Erna Sziksz, Ádám Vannay, Attila J Szabó, Katalin Eszter Müller, Áron Cseh, Kriszta Boros, Gábor Veres
INTRODUCTION: MicroRNAs (miRs) came recently into focus as promising novel research targets offering new insights into the pathogenesis of inflammatory bowel diseases (IBD). AIMS: The aim of our study was to identify a pediatric IBD (pIBD) characteristic miR profile serving as potential Crohn's disease (CD) and ulcerative colitis (UC) specific diagnostic pattern and to further analyze the related target genes. METHODS: Small RNA sequencing was performed on inflamed and intact colonic biopsies of CD, and control patients...
December 27, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28067753/long-term-extent-change-of-pediatric-onset-ulcerative-colitis
#4
Firas Rinawi, Amit Assa, Corina Hartman, Yael Mozer Glassberg, Vered Nachmias Friedler, Yoram Rosenbach, Ari Silbermintz, Noam Zevit, Raanan Shamir
BACKGROUND: Data describing extent change (progression or regression) in pediatric-onset ulcerative colitis (UC) are scarce. GOAL: We aimed to describe extent change in pediatric-onset UC during long-term follow-up and to assess predictors of extent change. STUDY: Medical charts of pediatric-onset UC patients with at least 5-year follow-up were analyzed retrospectively. Disease extent was determined using the Paris classification. It was examined at diagnosis and during follow-up at different time points...
January 6, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28063246/exacerbation-caused-by-5-asa-intolerance-in-children-with-ulcerative-colitis
#5
Hirotaka Shimizu, Katsuhiro Arai, Julian Tang, Kenji Hosoi, Rie Funayama
BACKGROUND: 5-aminosalicylate (5-ASA) is widely used as the first-line drug for ulcerative colitis (UC). 5-ASA is mostly a safe and effective drug, but it can bring about exacerbation due to 5-ASA intolerance. 5-ASA intolerance can be confusing and it can mislead physicians to consider unnecessary treatment escalation plan including corticosteroid (CS), biologics, or even surgery. In spite of the clinical importance of 5-ASA intolerance, there have been few publications about its incidence, clinical features, and diagnosis...
January 7, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28057843/diphenhydramine-for-acute-extrapyramidal-symptoms-after-propofol-administration
#6
James Sherer, Tomas Salazar, Kevin B Schesing, Shannon McPartland, Jeffrey Kornitzer
Extrapyramidal symptoms are an uncommon but well-recognized side effect after the administration of general anesthesia in patients without a significant neurologic history. Several case reports implicate propofol as the likely causative agent producing these symptoms, which include ballismus, dystonia, choreoathetosis, and opisthotonus. Currently, there is no clear consensus on first-line treatment of these symptoms. In each of the published cases, anticholinergic medications and benzodiazepines were central to initial management, although the speed and extent of symptom resolution were variable...
January 5, 2017: Pediatrics
https://www.readbyqxmd.com/read/28045777/capillary-flow-rates-in-the-duodenum-of-pediatric-ulcerative-colitis-patients-are-increased-and-unrelated-to-inflammation
#7
Deenaz Zaidi, Lucas Churchill, Hien Q Huynh, Matthew W Carroll, Rabin Persad, Eytan Wine
BACKGROUND: Inflammatory bowel diseases (IBD), including Crohn disease (CD) and ulcerative colitis (UC), are chronic pediatric disorders. Changes in vasculature are described in IBD but these could be secondary to inflammation and the role in pathogenesis is poorly understood. Assessing circulatory changes in typically unaffected sites in IBD (e.g., duodenum), when inflammation is absent, can identify vascular changes associated with pathogenesis. AIM: To measure capillary flow rates in duodenal mucosa using probe-based confocal laser endomicroscopy (pCLE) during endoscopy in children with IBD...
December 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28045775/seeing-without-looking-predicting-mucosal-healing-without-endoscopic-evaluation-in-pediatric-ulcerative-colitis
#8
Oren Ledder, Dan Turner
No abstract text is available yet for this article.
December 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28045769/diverting-ileostomy-for-the-treatment-of-severe-refractory-pediatric-inflammatory-bowel-disease
#9
Elizabeth C Maxwell, Noor Dawany, Robert N Baldassano, Petar Mamula, Peter Mattei, Lindsey Albenberg, Judith R Kelsen
OBJECTIVES: Diverting ileostomy is used as a temporizing therapy in patients with perianal Crohn disease; however, little data exist regarding its use for colonic disease. The primary aim of the present study was to determine the role of diversion in severe refractory colonic inflammatory bowel disease (IBD) in a pediatric population. METHODS: Retrospective study of patients who underwent diverting ileostomy at The Children's Hospital of Philadelphia from 2000 to 2014 for the management of severe, refractory colonic IBD...
December 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28039159/gut-microbiota-differs-between-children-with-inflammatory-bowel-disease-and-healthy-siblings-in-taxonomic-and-functional-composition-a-metagenomic-analysis
#10
Rebecca Luise Knoll, Kristoffer Forslund, Jens Roat Kultima, Claudius U Meyer, Ulrike Kullmer, Shinichi Sunagawa, Peer Bork, Stephan Gehring
Current treatment for pediatric IBD patients is often ineffective, with serious side effects. Manipulating the gut microbiota via fecal microbiota transplantation (FMT) is an emerging treatment approach but remains controversial. We aimed to assess the composition of the fecal microbiome through a comparison of pediatric IBD patients to their healthy siblings, evaluating risks and prospects for FMT in this setting. A Case-Control (Sibling) Study was conducted analyzing fecal samples of six children with Crohn's Disease (CD), six children with Ulcerative Colitis (UC) and 12 healthy siblings by metagenomic sequencing...
December 30, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28030510/clinical-and-fecal-microbial-changes-with-diet-therapy-in-active-inflammatory-bowel-disease
#11
David L Suskind, Stanley A Cohen, Mitchell J Brittnacher, Ghassan Wahbeh, Dale Lee, Michele L Shaffer, Kimberly Braly, Hillary S Hayden, Jani Klein, Benjamin Gold, Matthew Giefer, Angela Stallworth, Samuel I Miller
GOAL: To determine the effect of the specific carbohydrate diet (SCD) on active inflammatory bowel disease (IBD). BACKGROUND: IBD is a chronic idiopathic inflammatory intestinal disorder associated with fecal dysbiosis. Diet is a potential therapeutic option for IBD based on the hypothesis that changing the fecal dysbiosis could decrease intestinal inflammation. STUDY: Pediatric patients with mild to moderate IBD defined by pediatric Crohn's disease activity index (PCDAI 10-45) or pediatric ulcerative colitis activity index (PUCAI 10-65) were enrolled into a prospective study of the SCD...
December 27, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28008999/genetic-architecture-differences-between-pediatric-and-adult-onset-inflammatory-bowel-diseases-in-the-polish-population
#12
Jerzy Ostrowski, Agnieszka Paziewska, Izabella Lazowska, Filip Ambrozkiewicz, Krzysztof Goryca, Maria Kulecka, Tomasz Rawa, Jakub Karczmarski, Michalina Dabrowska, Natalia Zeber-Lubecka, Roman Tomecki, Anna Kluska, Aneta Balabas, Magdalena Piatkowska, Katarzyna Paczkowska, Jaroslaw Kierkus, Piotr Socha, Michal Lodyga, Grazyna Rydzewska, Maria Klopocka, Grazyna Mierzwa, Barbara Iwanczak, Elzbieta Krzesiek, Katarzyna Bak-Drabik, Jaroslaw Walkowiak, Beata Klincewicz, Piotr Radwan, Urszula Grzybowska-Chlebowczyk, Piotr Landowski, Agnieszka Jankowska, Bartosz Korczowski, Teresa Starzynska, Piotr Albrecht, Michal Mikula
Most inflammatory bowel diseases (IBDs) are classic complex disorders represented by common alleles. Here we aimed to define the genetic architecture of pediatric and adult-onset IBDs for the Polish population. A total of 1495 patients were recruited, including 761 patients with Crohn's disease (CD; 424 pediatric), 734 patients with ulcerative colitis (UC; 390 pediatric), and 934 healthy controls. Allelotyping employed a pooled-DNA genome-wide association study (GWAS) and was validated by individual genotyping...
December 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27989362/complications-in-colorectal-surgery
#13
Jason S Frischer, Beth Rymeski
Colorectal pediatric surgery is a diverse field that encompasses many different procedures. The pullthrough for Hirschsprung disease, the posterior sagittal anorectoplasty for anorectal malformations including complex cloaca reconstructions and the ileal pouch anal anastomosis for ulcerative colitis and familial adenomatous polyposis present some of the most technically challenging procedures pediatric surgeons undertake. Many children prevail successfully following these surgical interventions, however, a small number of patients suffer from complications following these procedures...
December 2016: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/27971741/treatment-gap-of-ulcerative-colitis-in-children-and-adolescents-in-poland-cost-utility-analysis-of-biosimilar-infliximab
#14
E Borowiack, M Borowiack, M Garbacka, M Kowalska Kędziora, A Nowotarska, G Raczyńska, K Bukowińska, M Klejman
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27956797/ex-vivo-response-to-mucosal-bacteria-and-muramyl-dipeptide-in-inflammatory-bowel-disease
#15
Claudia Loganes, Erica Valencic, Alessia Pin, Elisa Marini, Stefano Martelossi, Samuele Naviglio, Luigina De Leo, Tarcisio Not, Lorenzo Monasta, Alberto Tommasini, Annalisa Marcuzzi
AIM: To evaluate how mucosal bacteria impact on the spontaneous and muramyl dipeptide (MDP)-induced inflammation in Crohn's disease (CD) and ulcerative colitis (UC). METHODS: Colonic mucosal biopsies were collected from children with active or remissive CD, UC and controls. Two tissue samples were taken from inflamed mucosal segments (in patients with active disease) or from non-inflamed mucosa [in patients in remission or in healthy controls (HC)]. Experiments were performed in the presence or absence of antibiotics, to assess whether the disease-associated microbiota can modulate the cytokine response ex vivo...
November 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27942727/quantifying-the-burden-of-interhospital-cost-variation-in-pediatric-surgery-implications-for-the-prioritization-of-comparative-effectiveness-research
#16
Danielle B Cameron, Dionne A Graham, Carly E Milliren, Charity C Glass, Christina Feng, Feroze Sidhwa, Hariharan Thangarajah, Matthew Hall, Shawn J Rangel
Importance: Practice variation is believed to be a driver of excess health care spending, although few objective data exist to guide the prioritization of comparative effectiveness research (CER) in pediatric surgery. Objective: To identify high-priority general pediatric surgical procedures for CER on the basis of the following 2 complementary measures: the magnitude of interhospital cost variation as a surrogate for the need for and potential effect of CER at the patient level and the cumulative fiscal burden of this cost variation when considering the case volume from all hospitals as a surrogate for public health relevance...
December 12, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27941580/an-attachment-based-model-of-the-relationship-between-childhood-adversity-and-somatization-in-children-and-adults
#17
Robert G Maunder Md, Jonathan J Hunter, Leslie Atkinson, Meir Steiner, Ashley Wazana, Alison Fleming, Ellen Moss, Helene Gaudreau, Michael Meaney, Robert D Levitan
OBJECTIVE: An attachment model was used to understand how maternal sensitivity and adverse childhood experiences are related to somatization. METHODS: We examined maternal sensitivity at 6 and 18 months and somatization at 5 years in 292 children in a longitudinal cohort study. We next examined attachment insecurity and somatization (health anxiety, physical symptoms) in four adult cohorts: healthy primary care patients (AC1, n=67), ulcerative colitis in remission (AC2, n = 100), hospital workers (AC3, n=157), and paramedics (AC4, n=188)...
December 9, 2016: Psychosomatic Medicine
https://www.readbyqxmd.com/read/27941190/assessment-of-induction-therapy-with-infliximab-in-children-with-moderate-to-severe-ulcerative-colitis-a-multi-center-study
#18
Monika Szychta, Anna Wiernicka, Maciej Dądalski, Piotr Landowski, Beata Klincewicz, Katarzyna Karolewska-Bochenek, Grażyna Czaja-Bulsa, Elzbieta Jarocka-Cyrta, Bartosz Korczowski, Malgorzata Sladek, Jaroslaw Kierkus
THE AIM OF THE STUDY: Assessment of clinical and endoscopic efficacy of induction therapy with infliximab in children with ulcerative colitis. MATERIAL AND METHODS: This is a retrospective analysis of medical records of pediatric patients with moderate to severe UC who had received at least one infusion of infliximab in Polish pediatric academic clinical centers from 2003 to 2013. The primary endpoint was clinical remission rate at week 10, (PUCAI score <10 points) while the secondary endpoints were: clinical response rate (>19-points decrease in PUCAI), mucosal response rate (defined as an improvement of the Baron score), and mucosal healing rate (Baron score 0 or 1)...
2016: Developmental Period Medicine
https://www.readbyqxmd.com/read/27941189/clinical-evaluation-of-children-with-ulcerative-colitis-treated-between-2013-2015-own-experience
#19
Monika Meglicka, Michał Szczepański, Maciej Dądalski, Jarosław Kierkuś
AIM: Evaluation of the changes in the endoscopic, laboratory and clinical status in children with ulcerative colitis (UC) with regard to the duration of the disease. MATERIAL AND METHODS: 91 children with UC were involved in the study. Each of them had colonoscopy and their laboratory values were tested. We assessed the colonoscopy results by the Paris classification and by the Baron score. Moreover, demographic, clinical and anthropometric data were collected. We divided our patients into five subgroups depending on the duration of the disease...
2016: Developmental Period Medicine
https://www.readbyqxmd.com/read/27932194/associations-between-nod2-irgm-and-ormdl3-polymorphisms-and-pediatric-onset-inflammatory-bowel-disease-in-the-lithuanian-population
#20
Gitana Pranculienė, Rūta Steponaitienė, Jurgita Skiecevičienė, Rūta Kučinskienė, Gediminas Kiudelis, Kęstutis Adamonis, Liutauras Labanauskas, Limas Kupčinskas
BACKGROUND AND OBJECTIVE: Recent GWAS and meta-analyses have revealed about 200 susceptibility genes/loci for inflammatory bowel diseases (IBD). However, only a small number of studies were performed in early-onset IBD. The aim of this study was to assess the association between NOD2, IL23R, ATG16L1, IRGM, IL10, NKX2-3 and ORMDL3 variants and early-onset IBD. MATERIALS AND METHODS: A total of 76 affected individuals (30 with Crohn's disease [CD] and 46 with ulcerative colitis [UC]) at the age of ≤17 years and 158 matched controls recruited in Lithuania were genotyped for the known genetic susceptibility variants in NOD2 (Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847)), IL23R (rs11209026), ATG16L1 (rs2241880), IRGM (rs4958847), IL10 (rs3024505), NKX2-3 (rs11190140) and ORMDL3 (rs2872507) genes...
2016: Medicina
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