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https://www.readbyqxmd.com/read/27906801/the-prevalence-and-impact-of-functional-abdominal-pain-disorders-in-children-with-inflammatory-bowel-diseases-ibd-fapd
#1
Kevin L Watson, Sandra C Kim, Brendan M Boyle, Miguel Saps
OBJECTIVES: We sought to describe the prevalence of the overlap of functional abdominal pain disorders (FAPDs) in children with inflammatory bowel diseases (IBD), a condition we have designated as IBD-FAPD. We also aimed to describe the psychological profile of this group, assess predictors of disease and the impact of IBD-FAPD on quality of life. METHODS: This cross-sectional prospective study included patients aged 8-18 years with a diagnosis of IBD. Disease activity was assessed by physician's global assessment, laboratory studies, and aPCDAI or PUCAI scoring...
November 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27905628/-virulence-mechanisms-of-enteropathogenic-escherichia-coli
#2
Ana Elvira Farfán-García, Sandra Catherine Ariza-Rojas, Fabiola Andrea Vargas-Cárdenas, Lizeth Viviana Vargas-Remolina
Acute diarrheal disease (ADD) is a global public health problem, especially in developing countries and is one of the causes of mortality in children under five. ADD etiologic agents include viruses, bacteria and parasites in that order. Escherichia coli bacteria it is classified as a major diarrheagenic agent and transmitted by consuming contaminated water or undercooked foods. This review compiled updates on information virulence factors and pathogenic mechanisms involved in adhesion and colonization of seven pathotypes of E...
August 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/27904441/dynamic-contrast-enhanced-ultrasound-of-the-bowel-wall-with-quantitative-assessment-of-crohn-s-disease-activity-in-childhood
#3
Damjana Kljucevsek, Dubravka Vidmar, Darja Urlep, Rok Dezman
BACKGROUND: Contrast-enhanced ultrasound (CEUS) has become an established non-invasive, patient-friendly imaging technique which improves the characterization of lesions. In addition, dynamic contrast-enhanced ultrasound (DCE-US) provides valuable information concerning perfusion of examined organs. This review addresses current applications of CEUS in children, focused on DCE-US of the bowel wall in patients with Crohn disease, which enables realtime assessment of the bowel wall vascularity with semi-quantitative and quantitative assessment of disease activity and response to medical treatment...
December 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27896868/crohn-s-disease-should-be-considered-in-children-with-inflammatory-oral-lesions
#4
REVIEW
Anna Skrzat, Dorota Olczak-Kowalczyk, Anna Turska- Szybka
: This systematic review presents the oral manifestations of paediatric Crohn's disease. Our review of 28 papers published from 2000 to 2015 showed that the prevalence of oral manifestations was 10 to 80%. Specific symptoms included mucosal tags, swelling of the lips, cheeks and gingiva and cobblestoning mucosa. Non-specific symptoms included aphthous-like ulcers, angular cheilitis, lip fissuring and gingivitis. CONCLUSION: The oral manifestations of Crohn's disease might precede intestinal inflammation or coincide with it...
November 29, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27890312/variables-associated-with-loss-of-ileoanal-pouches-constructed-in-childhood
#5
Khaled Abdelaal, Bruce Jaffray
AIMS: To quantify the incidence of loss of an ileoanal pouch in children and to identify variables associated this event. METHODS: Logistic regression of possible explanatory variables: age, sex, indication for procto-colectomy, pre-operative continence status, use of immunosuppressive drugs, open or laparoscopic surgery, number of stages, anastomotic leak, operative complication excluding anastomotic leak, performance of revisional surgery, albumin concentration and platelet count at time of surgery, rank order in series...
November 13, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27889728/pediatric-inflammatory-bowel-disease
#6
Akshay Kapoor, Vidyut Bhatia, Anupam Sibal
Background: The incidence of inflammatory bowel disease is increasing in the pediatric population worldwide. NEED AND PURPOSE OF REVIEW: There is paucity of high quality scientific data regarding pediatric inflammatory bowel disease. Most of the guidelines are offshoots of work done in adults, which have been adapted over time to diagnose and treat pediatric patients. This is in part related to the small numbers in pediatric inflammatory bowel disease and less extensive collaboration for multicentric trials both nationally and internationally...
November 15, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27887202/serological-markers-in-diagnosis-of-pediatric-inflammatory-bowel-disease-and-as-predictors-for-early-tumor-necrosis-factor-blocker-therapy
#7
Christine Olbjørn, Milada Cvancarova Småstuen, Espen Thiis-Evensen, Britt Nakstad, Morten Harald Vatn, Gøri Perminow
OBJECTIVE: To describe the prevalence of serological markers in newly diagnosed treatment-naïve pediatric inflammatory bowel disease (IBD), their utility in differentiating Crohn's disease (CD), ulcerative colitis (UC) and symptomatic non-IBD patients and whether serological markers are associated with early TNF blocker treatment. MATERIAL AND METHODS: Ninety-six children and adolescents <18 years, 58 with IBD and 38 symptomatic non-IBD controls were included...
November 25, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27882164/inflammatory-bowel-disease-in-chinese-children-a-retrospective-analysis-of-49-cases
#8
Ying Zhou, Ying Huang
To present study reports the clinical characteristics, diagnosis and management of pediatric patients with inflammatory bowel disease (IBD) in China. Clinical records of 49 pediatric patients with IBD at Fudan University Children's Hospital (Shanghai, China) between July 2001 and May 2012 were reviewed. Of 49 patients (30 males and 19 females), 8 patients had ulcerative colitis (UC) and 41 patients had Crohn's disease (CD). The mean age was 10.4 years in patients with UC and 10.1 years in patients with CD. The percentages of patients with UC with abdominal pain, diarrhea or rectal bleeding were 62...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27875505/radiologic-predictors-of-surgery-in-newly-diagnosed-pediatric-crohn-disease-patients
#9
Damien Parker, Boaz Karmazyn, Steven J Steiner
OBJECTIVES: The aim of the present study was to assess whether small bowel imaging conducted at the time of diagnosis could be used as a predictor of small bowel surgical intervention in a population of pediatric patients with Crohn disease (CD). METHODS: A retrospective analysis of small bowel imaging within 30 days of diagnosis of pediatric CD was conducted. Patients were divided into 2 groups based on small bowel imaging: those with no or minor abnormalities (71%) and those with more extensive or obstructive abnormalities (29%)...
December 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27875353/cannabinoid-receptor-2-functional-variant-contributes-to-the-risk-for-pediatric-inflammatory-bowel-disease
#10
Caterina Strisciuglio, Giulia Bellini, Erasmo Miele, Massimo Martinelli, Sabrina Cenni, Chiara Tortora, Carlo Tolone, Emanuele Miraglia Del Giudice, Francesca Rossi
GOALS: We conducted a case-control association analysis to establish the role of a common CB2 functional variant, Q63R, in the susceptibility to inflammatory bowel disease (IBD). BACKGROUND: Endocannabinoids may limit intestinal inflammation through cannabinoid receptor 1 and/or 2 (CB1, CB2). STUDY: We genotyped 217 pediatric IBD patients [112 Crohn's disease (CD), 105 ulcerative colitis (UC)] and 600 controls for the CB2-Q63R variant by Taqman assay...
November 21, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27862714/de-novo-inflammatory-bowel-disease-after-pediatric-kidney-or-liver-transplant
#11
Melissa A Fernandes, Hillary J Braun, Kim Evason, Sue Rhee, Emily R Perito
A subset of children who receive a liver and/or kidney transplant develop de novo inflammatory bowel disease-like chronic intestinal inflammation, not explained by infection or medications, following transplant. We have conducted a single-center, retrospective case series describing the unique clinical and histologic features of this IBD-like chronic intestinal inflammation following solid organ transplant. At our center, nine of 327 kidney or liver recipients developed de novo IBD following transplant (six liver, two kidney, one liver-kidney)...
November 11, 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27861181/genetic-risk-for-inflammatory-bowel-disease-is-a-determinant-of-crohn-s-disease-development-in-chronic-granulomatous-disease
#12
Chengrui Huang, Suk See De Ravin, Adam R Paul, Theo Heller, Nancy Ho, Lisa Wu Datta, Christa S Zerbe, Beatriz E Marciano, Douglas B Kuhns, Howard A Kader, Steven M Holland, Harry L Malech, Steven R Brant
BACKGROUND: Approximately, one-third to one-half of children with chronic granulomatous disease (CGD) develop gastrointestinal inflammation characteristic of idiopathic inflammatory bowel disease (IBD), usually Crohn's disease. We hypothesized that the overall IBD genetic risk, determined by IBD genetic risk score (GRS), might in part determine IBD development in CGD. METHODS: We reviewed medical records to establish IBD diagnoses in CGD subjects seen at NIAID. IBD risk single nucleotide polymorphism genotypes were determined using the Immunochip, and GRS were estimated by Mangrove...
December 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27858582/long-term-outcome-of-laparoscopic-duhamel-procedure-for-extended-hirschsprung-s-disease
#13
Cécile O Muller, Guillaume Rossignol, Louise Montalva, Jerome Viala, Christine Martinez-Vinson, Alexis Mosca, Dominique Berrebi, Arnaud Bonnard
BACKGROUND: The aim of our study was to report our experience in extended Hirschsprung's disease (HD) in children operated on by laparoscopy. PATIENTS AND METHODS: Retrospective data collection from a single center from 1991 to 2013 concerned extended forms of HD operated on by laparoscopic Duhamel procedure and included extension of aganglionosis, comorbidities, short and late postoperative outcome, and results of endoscopy when performed. RESULTS: Thirty patients presented an extended form of aganglionosis: 5 involving the transverse colon, 10 the right colon, and 15 the ileum (median length = 15 cm, range 1-60)...
November 18, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27845027/clinical-effectiveness-and-cost-effectiveness-of-use-of-therapeutic-monitoring-of-tumour-necrosis-factor-alpha-tnf-%C3%AE-inhibitors-lisa-tracker%C3%A2-enzyme-linked-immunosorbent-assay-elisa-kits-tnf-%C3%AE-blocker-elisa-kits-and-promonitor%C3%A2-elisa-kits-versus-standard-care
#14
Karoline Freeman, Martin Connock, Peter Auguste, Sian Taylor-Phillips, Hema Mistry, Deepson Shyangdan, Rachel Court, Ramesh Arasaradnam, Paul Sutcliffe, Aileen Clarke
BACKGROUND AND OBJECTIVES: Systematic reviews and economic modelling of clinical effectiveness and cost-effectiveness of therapeutic monitoring of tumour necrosis factor alpha (TNF-α) inhibitors [using LISA-TRACKER(®) enzyme-linked immunosorbent assay (ELISA) kits (Theradiag, Marne La Vallee, France, or Alpha Laboratories, Heriot, UK), TNF-α-Blocker ELISA kits (Immundiagnostik AG, Bensheim, Germany) and Promonitor(®) ELISA kits (Proteomika, Progenika Biopharma, Bizkaia, Spain)] versus standard care for Crohn's disease (CD)...
November 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27824647/genetic-risk-for-inflammatory-bowel-disease-is-a-determinant-of-crohn-s-disease-development-in-chronic-granulomatous-disease
#15
Chengrui Huang, Suk S De Ravin, Adam R Paul, Theo Heller, Nancy Ho, Lisa Wu Datta, Christa S Zerbe, Beatriz E Marciano, Douglas B Kuhns, Howard A Kader, Steven M Holland, Harry L Malech, Steven R Brant
BACKGROUND: Approximately, one-third to one-half of children with chronic granulomatous disease (CGD) develop gastrointestinal inflammation characteristic of idiopathic inflammatory bowel disease (IBD), usually Crohn's disease. We hypothesized that the overall IBD genetic risk, determined by IBD genetic risk score (GRS), might in part determine IBD development in CGD. METHODS: We reviewed medical records to establish IBD diagnoses in CGD subjects seen at NIAID. IBD risk single nucleotide polymorphism genotypes were determined using the Immunochip, and GRS were estimated by Mangrove...
December 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27822107/the-danish-national-registry-for-biological-therapy-in-inflammatory-bowel-disease
#16
REVIEW
Lone Larsen, Michael Dam Jensen, Michael Due Larsen, Rasmus Gaardskær Nielsen, Niels Thorsgaard, Ida Vind, Signe Wildt, Jens Kjeldsen
AIM: The aims of The Danish National Registry for Biological Therapy in Inflammatory Bowel Disease are to ensure that biological therapy and the clinical management of patients with inflammatory bowel disease (IBD) receiving biological treatment are in accordance with the national clinical guidelines and, second, the database allows register-based clinical epidemiological research. STUDY POPULATION: The study population comprises all Danish patients with IBD (both children and adults) with ulcerative colitis, Crohn's disease, and IBD unclassified who receive biological therapy...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27811291/fungal-microbiota-profile-in-newly-diagnosed-treatment-na%C3%A3-ve-children-with-crohn-disease
#17
Mohammad El Mouzan, Feng Wang, Mohammad Al Mofarreh, Rajita Menon, Ahmad Al Barrag, Kirill S Korolev, Ahmad Al Sarkhy, Mona Al Asmi, Yassin Hamed, Anjum Saeed, Scot Dowd, Asaad Assiri, Harland Winter
BACKGROUND & AIMS: although increasing evidence suggests a role for fungi in inflammatory bowel disease (IBD), data are scarce and mostly from adults. Our aim was to define the characteristics of fungal microbiota in newly-diagnosed treatment-naïve children with Crohn disease (CD). METHODS: The children referred for colonoscopy were prospectively enrolled in the study at King Khalid University Hospital, King Saud University and Al Mofarreh Polyclinics in Riyadh...
November 3, 2016: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/27808471/neutrophil-volume-distribution-width-as-a-new-marker-in-detecting-inflammatory-bowel-disease-activation
#18
Y Aydemir, A Pınar, G Hızal, H Demir, I N Saltık Temizel, H Özen, F Akbıyık, A Yüce
INTRODUCTION: We sought to investigate the value of neutrophil volume distribution width in detecting inflammatory bowel disease activation. METHODS: Patients with infection and accompanying inflammatory disease were excluded. All the patients were diagnosed and classified according to Porto criteria and Paris classification, respectively. Physician global assessment, pediatric Crohn's disease and pediatric ulcerative colitis activity indexes and fecal calprotectin were used to define disease activation...
November 3, 2016: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/27805918/early-changes-in-microbial-community-structure-are-associated-with-sustained-remission-after-nutritional-treatment-of-pediatric-crohn-s-disease
#19
Katherine A Dunn, Jessica Moore-Connors, Brad MacIntyre, Andrew W Stadnyk, Nikhil A Thomas, Angela Noble, Gamal Mahdi, Mohsin Rashid, Anthony R Otley, Joseph P Bielawski, Johan Van Limbergen
BACKGROUND: Clinical remission achieved by exclusive enteral nutrition (EEN) is associated with marked microbiome changes. In this prospective study of exclusive enteral nutrition, we employ a hierarchical model of microbial community structure to distinguish between pediatric Crohn's disease patients who achieved sustained remission (SR) and those who relapsed early (non-SR), after restarting a normal diet. METHODS: Fecal samples were obtained from 10 patients (age 10-16) and from 5 healthy controls (age 9-14)...
December 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27801751/extraintestinal-manifestations-of-pediatric-inflammatory-bowel-disease-prevalence-presentation-and-anti-tnf-treatment
#20
Thomas Greuter, Fabio Bertoldo, Roman Rechner, Alex Straumann, Luc Biedermann, Jonas Zeitz, Benjamin Misselwitz, Michael Scharl, Gerhard Rogler, Ekaterina Safroneeva, Raja A Ali, Christian Braegger, Klaas Heyland, Pascal Mueller, Andreas Nydegger, Laetitia-Marie Petit, Susanne Schibli, Raoul I Furlano, Johannes Spalinger, Michela Schäppi, Samuel Zamora, Florian Froehlich, Denise Herzog, Alain M Schoepfer, Stephan R Vavricka
BACKGROUND: There is a paucity of data on extraintestinal manifestations (EIM) and their treatment in pediatric patients with inflammatory bowel disease (IBD). METHODS: Since 2008, the Pediatric Swiss IBD Cohort Study has collected data on the pediatric IBD population in Switzerland. Data on 329 patients were analyzed retrospectively. RESULTS: 55 patients (16.7%) suffered from 1-4 EIM (39 Crohn's disease, 12 ulcerative colitis and 4 IBD-Unclassified (IBD-U) patients)...
October 31, 2016: Journal of Pediatric Gastroenterology and Nutrition
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