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https://www.readbyqxmd.com/read/29788410/differentiation-between-pediatric-irritable-bowel-syndrome-and-inflammatory-bowel-disease-based-on-fecal-scent-proof-of-principle-study
#1
Sofie Bosch, Nora van Gaal, Roy P Zuurbier, James A Covington, Alfian N Wicaksono, Maarten H Biezeveld, Marc A Benninga, Chris J Mulder, Nanne K H de Boer, Tim G J de Meij
Background: The diagnostic work-up of pediatric irritable bowel syndrome (IBS) and functional abdominal pain-not otherwise specified (FAP-NOS) commonly includes invasive tests for discrimination from inflammatory bowel disease (IBD). As this carries a high burden on patients, an ongoing need exists for development of noninvasive diagnostic biomarkers for IBS and FAP-NOS. Several studies have shown microbiota alterations in IBS/FAP, which are considered to be reflected by fecal volatile organic compounds (VOCs)...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29788152/early-arthritis-is-associated-with-failure-of-immunosuppressive-drugs-and-severe-pediatric-crohn-s-disease-evolution
#2
Naïm Ouldali, Jean-Pierre Hugot, Jérôme Viala, Mohamed Damir, Christine Martinez-Vinson, Ulrich Meinzer
Background: Crohn's disease (CD) is a chronic relapsing inflammatory disease. To optimize therapeutic decision making, it is essential to identify parameters that allow early prediction of a severe disease course. The aim of this study was to assess the link between arthritis and medium-term therapeutic failure in pediatric CD. Methods: We conducted a population-based cohort study with prospectively collected electronic data. To be included, patients must be younger than 17 years and have a confirmed CD diagnosed between 2005 and 2014...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29788058/modeling-immunization-to-infliximab-in-children-with-crohn-s-disease-using-population-pharmacokinetics-a-pilot-study
#3
Antoine Petitcollin, Oriane Leuret, Camille Tron, Florian Lemaitre, Marie-Clémence Verdier, Gilles Paintaud, Guillaume Bouguen, Stéphanie Willot, Eric Bellissant, David Ternant
Background: Antidrug antibodies (ADAs) dramatically increase infliximab clearance and are responsible for underexposure to the drug, leading to treatment failure. This pilot study aimed at developing a population pharmacokinetic model to detect and describe an early increase in infliximab clearance due to ADA. Methods: Twenty children with Crohn's disease (CD) were followed for 1 year or until treatment failure. Infliximab trough concentration, ADA, C-reactive protein (CRP), and Paediatric Crohn's Disease Activity Index (PCDAI) were recorded at each visit...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29783232/peculiarities-of-crohn-s-disease-in-children-the-way-from-diagnosis-verification-to-the-development-of-complications-clinical-case
#4
Tetyana O Kryuchko, Olha A Poda, Inna M Nesina, Vira P Harshman
OBJECTIVE: Introduction: Despite increasing frequency of inflammatory diseases of the intestine in the children worldwide, verification of Crohn's disease (CD) diagnosis in pediatric practice has not studied yet and it is difficult for clinician to determine the stage of the disease. The aim of our study was to analyze clinical case of Crohn's disease (CD) in a child based on literature data and own monitoring. PATIENTS AND METHODS: Materials and methods: 13 year old patient was involved in our examination who took complex lab and instrumental investigation, which allows verifying inflammatory intestinal pathology such as Crohn's disease...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29775795/response-to-biologics-delay-progression-of-crohn-s-disease-in-children-but-not-early-surgery
#5
EDITORIAL
Cortney R Ballengee, Subra Kugathasan
No abstract text is available yet for this article.
May 15, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29764567/-features-and-management-of-very-early-onset-inflammatory-bowel-disease
#6
Jie-Yu You
Inflammatory bowel disease (IBD) is a chronic nonspecific intestinal inflammatory disease of unknown etiology. This disease includes three main types: Crohn′s disease (CD), ulcerative colitis (UC), and IBD-unclassified (IBD-U). IBD is frequently presented in adults, but in recent years, there is a rising incidence in pediatric populations. Very early onset IBD (VEO-IBD) is a fraction of pediatric IBD, but they have exclusive phenotypic and genetic characteristics such that they are accompanied by severe disease course and resistance to conventional therapy...
May 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29760546/thiopurines-are-negatively-associated-with-anthropometric-parameters-in-pediatric-crohn-s-disease
#7
Neera Gupta, Robert H Lustig, Cewin Chao, Eric Vittinghoff, Howard Andrews, Cheng-Shiun Leu
AIM: To determine the distribution of anthropometric parameter (AP)- z -scores and characterize associations between medications/serum biomarkers and AP- z -scores in pediatric Crohn's disease (CD). METHODS: CD patients [< chronological age (CA) 21 years] were enrolled in a cross-sectional study. Descriptive statistics were generated for participants' demographic characteristics and key variables of interest. Paired t -tests were used to compare AP- z -scores calculated based on CA (CA z -scores) and bone age (BA) (BA z -scores) for interpretation of AP's...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29754190/allergic-and-immunologic-perspectives-of-inflammatory-bowel-disease
#8
REVIEW
Kofi Clarke, Jayakrishna Chintanaboina
Inflammatory bowel disease (IBD) is a chronic immune-mediated inflammatory condition primarily involving the gastrointestinal tract. It includes Crohn's disease (CD), ulcerative colitis (UC), and a less common phenotype-indeterminate colitis. It is thought to result from a complex interplay of environmental, microbial, and host factors including genetic factors, although the exact mechanism is not known. Dietary factors have been shown to play a role in the pathogenesis of IBD and can potentially alter the intestinal microbiota as well as disrupt the immune function in the gut...
May 12, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29740348/could-sodium-chloride-be-an-environmental-trigger-for-immune-mediated-diseases-an-overview-of-the-experimental-and-clinical-evidence
#9
REVIEW
Eric Toussirot, Matthieu Béreau, Charline Vauchy, Philippe Saas
Immune mediated diseases (IMDs) are complex chronic inflammatory diseases involving genetic and environmental factors. Salt intake has been proposed as a diet factor that can influence the immune response. Indeed, experimental data report the influence of sodium chloride on the differentiation of naive CD4+ T cells into IL-17 secreting T helper (Th) cells (Th17 cells), by a mechanism involving the serum glucocorticoid kinase-1 (SGK1) that promotes the expression of the IL-23 receptor (IL-23R). The IL-23/IL-23R is critical for pathogenic inflammatory Th17 cell differentiation...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29724086/the-long-term-effect-of-early-anti-tumor-necrosis-factor-on-restoration-of-growth-in-pediatric-crohn-s-disease
#10
EDITORIAL
Jung Ok Shim, Yoon Tae Jeen
No abstract text is available yet for this article.
May 15, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29718391/serologic-reactivity-reflects-clinical-expression-of-ulcerative-colitis-in-children
#11
Elizabeth A Spencer, Sonia M Davis, David R Mack, Brendan M Boyle, Anne M Griffiths, Neal S LeLeiko, Cary G Sauer, David J Keljo, James F Markowitz, Susan S Baker, Joel R Rosh, Robert N Baldassano, Maria Oliva-Hemker, Marian D Pfefferkorn, Anthony R Otley, Melvin B Heyman, Joshua D Noe, Ashish S Patel, Paul A Rufo, M Alison Marquis, Thomas D Walters, Margaret H Collins, Subra Kugathasan, Lee A Denson, Jeffrey S Hyams, Marla C Dubinsky
Background: In contrast to pediatric Crohn's disease (CD), little is known in pediatric ulcerative colitis (UC) about the relationship between disease phenotype and serologic reactivity to microbial and other antigens. Aim: The aim of this study was to examine disease phenotype and serology in a well-characterized inception cohort of children newly diagnosed with UC during the PROTECT Study (Predicting Response to Standardized Pediatric Colitis Therapy). Methods: Patients were recruited from 29 participating centers...
April 30, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29718299/improving-quality-in-the-care-of-patients-with-inflammatory-bowel-diseases
#12
Matthew D Egberg, Ajay S Gulati, Ziad F Gellad, Gil Y Melmed, Michael D Kappelman
Efforts to improve healthcare quality were firmly established before the Institute of Medicine (IOM) historic 2000 and 2001 reports, To Err is Human Building a Safer Health System and Crossing the Quality Chasm: A New Health System for the 21st Century Despite the long-standing healthcare quality improvement (QI) efforts that date back to the turn of the 20th century, the IOM reports significantly advanced the awareness of healthcare quality deficits and the resulting risk to patients from those gaps in care...
April 27, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29718224/the-association-of-diet-and-exercise-with-body-composition-in-pediatric-crohn-s-disease
#13
Dale Lee, James D Lewis, Justine Shults, Robert N Baldassano, Jin Long, Rita Herskovitz, Babette Zemel, Mary B Leonard
Background: In pediatric Crohn's disease, fat mass improves over time with treatment, but lean mass deficits persist. This observational study of the associations of physical activity and dietary intake with lean mass and muscle strength in children with Crohn's disease was ancillary to a previously reported randomized clinical trial of an intervention to improve bone health. Methods: In this study, 138 participants were followed at baseline and at 6, 12, and 24 months with evaluation of lean and fat mass using DXA, muscle strength (peak torque), Crohn's characteristics, dietary intake, time in moderate to vigorous physical activity (MVPA), and serum insulin-like growth factor-1 (IGF-1) and tumor necrosis factor-alpha (TNF-α)...
April 27, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29713253/characteristics-and-incidence-trends-for-pediatric-inflammatory-bowel-disease-in-daegu-kyungpook-province-in-korea-a-multi-center-study
#14
Suk Jin Hong, Seung Man Cho, Byung-Ho Choe, Hyo Jeong Jang, Kwang Hae Choi, Ben Kang, Jung Eun Kim, Jun Hyun Hwang
Background: Inflammatory bowel disease (IBD) is a heterogeneous chronic disease of unknown etiology. Although it is an important disease that shows a rapid increase in pediatric population, there are no pediatric studies that represent a specific region in Korea. Therefore, we studied the epidemiological and phenotypic characteristics of pediatric IBD in Daegu-Kyungpook province, Korea. Methods: We included 122 children with pediatric IBD initially diagnosed at one of four university hospitals in Daegu-Kyungpook province between July 2010 and June 2016...
April 30, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29701656/enteral-nutrition-in-the-management-of-pediatric-and-adult-crohn-s-disease
#15
REVIEW
Tawnya Hansen, Donald R Duerksen
Genetic and environmental factors are thought to profoundly influence the pathophysiology of Crohn&rsquo;s disease (CD). Changes in dietary and hygiene patterns affect the interactions between the immune system and environment. The gut microbiome is responsible for mediating host immune response with significant dysbiosis observed in individuals with CD. Diet therapy using exclusive enteral nutrition (EEN) has been studied as primary therapy for the management of CD. EEN may cultivate the presence of beneficial microbiota, improve bile acid metabolism, and decrease the number of dietary microparticles possibly influencing disease and immune activity...
April 26, 2018: Nutrients
https://www.readbyqxmd.com/read/29697550/use-of-infliximab-biosimilar-versus-originator-in-a-paediatric-united-kingdom-inflammatory-bowel-disease-induction-cohort
#16
Neil Chanchlani, Kajal Mortier, Linda J Williams, Rafeeq Muhammed, Marcus K H Auth, Mike Cosgrove, Andrew Fagbemi, John Fell, Sonny Chong, Veena Zamvar, Warren Hyer, W Michael Bisset, Mary-Anne Morris, Astor Rodrigues, Sally G Mitton, Su Bunn, R Mark Beattie, Anne Willmott, David C Wilson, Richard K Russell
OBJECTIVES: To summarize short-term effectiveness, safety, and cost of using infliximab biosimilar (IFX-B) drugs, (Inflectra™ and Remsima™) compared to originator infliximab (IFX-O) (Remicade®) in biologic naive pediatric inflammatory bowel disease in the United Kingdom. METHODS: Prospective audit of patients starting anti-TNF therapy. Disease severity, response to treatment, and remission rate was measured by Pediatric Crohn's Disease Activity Index (PCDAI) and/or Physician Global Assessment (PGA)...
April 23, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29688466/quality-of-life-in-inflammatory-bowel-disease-a-systematic-review-and-meta-analyses-part-ii
#17
Simon R Knowles, Laurie Keefer, Helen Wilding, Catherine Hewitt, Lesley A Graff, Antonina Mikocka-Walus
Background: There has been burgeoning interest in quality of life (QoL) in inflammatory bowel disease (IBD) in recent decades, with hundreds of studies each year now assessing this outcome. This paper is part 2 of a systematic review evaluating 5 key QoL comparisons within IBD states and relative to others without IBD. Part 1 examined QoL comparing IBD and a healthy/general population and other medically ill groups. Part 2, presented here, examines within-disease comparisons of active/inactive disease, Ulcerative colitis (UC) / Crohn's disease (CD), and change in QoL over time...
April 23, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29688409/methotrexate-for-the-treatment-of-pediatric-crohn-s-disease-a-systematic-review-and-meta-analysis
#18
Ruben J Colman, Rachel C Lawton, Marla C Dubinsky, David T Rubin
Background: Methotrexate (MTX) is an immunomodulator used for the treatment of pediatric inflammatory bowel disease (IBD). There are currently no RCTs that assess the treatment efficacy of methotrexate within the pediatric IBD patient population. This systematic review and meta-analysis assesses the efficacy of MTX therapy among the existing pediatric literature. Methods: A systematic literature search was performed using MEDLINE and the Cochrane library from inception until March 2016...
April 23, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29688090/high-and-low-body-mass-index-may-predict-severe-disease-course-in-children-with-inflammatory-bowel-disease
#19
Anat Yerushalmy-Feler, Amir Ben-Tov, Yael Weintraub, Achiya Amir, Tut Galai, Hadar Moran-Lev, Shlomi Cohen
OBJECTIVES: Inflammatory bowel disease (IBD) has been historically associated with underweight and malnutrition. The impact of both underweight and obesity on the clinical course of IBD in adults is controversial. This study described the association between body mass index (BMI) at diagnosis to disease course in children with IBD. METHODS: We reviewed the medical records of children with IBD from the database of the 'Dana-Dwek' Children's Hospital between 2010 and 2016...
April 24, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29687785/filiform-polyposis-in-ulcerative-colitis-a-rare-pediatric-case
#20
Nafiye Urgancı, Derya Kalyoncu
BACKGROUND: Filiform polyposis is a rare benign condition referred to as inflammatory polyposis, or pseudopolyposis that is usually found in association with Crohn's disease, ulcerative colitis or granulomatous colitis which is formed by non-specific mucosal and submucosal reactions to previous severe inflammation. It is characterized by multiple finger-like projections most commonly in the transverse and descending colon. CASE REPORT: A 15-year-old girl with UC who had filiform polyposis is presented...
April 24, 2018: Balkan Medical Journal
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