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(Children or kids or pediatric) crohn's

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https://www.readbyqxmd.com/read/28222161/the-distinct-features-of-microbial-dysbiosis-of-crohn-s-disease-do-not-occur-to-the-same-extent-in-their-unaffected-genetically-linked-kindred
#1
Umer Zeeshan Ijaz, Christopher Quince, Laura Hanske, Nick Loman, Szymon T Calus, Martin Bertz, Christine A Edwards, Daniel R Gaya, Richard Hansen, Paraic McGrogan, Richard K Russell, Konstantinos Gerasimidis
BACKGROUND/AIMS: Studying the gut microbiota in unaffected relatives of people with Crohn's disease (CD) may advance our understanding of the role of bacteria in disease aetiology. METHODS: Faecal microbiota composition (16S rRNA gene sequencing), genetic functional capacity (shotgun metagenomics) and faecal short chain fatty acids (SCFA) were compared in unaffected adult relatives of CD children (CDR, n = 17) and adult healthy controls, unrelated to CD patients (HUC, n = 14)...
2017: PloS One
https://www.readbyqxmd.com/read/28216137/low-predictive-value-of-histopathological-scoring-system-for-complications-development-in-children-with-crohn-s-disease
#2
Ondrej Fabian, Ondrej Hradsky, Kristyna Potuznikova, Alena Kalfusova, Lenka Krskova, Ludmila Hornofova, Josef Zamecnik, Jiri Bronsky
OBJECTIVES: In pediatric Crohn's disease (PCD), the benefit of microscopy in disease activity assessment and prediction of clinical outcome is, due to the focality and transmurality of the inflammation, disputable. We investigated whether histopathological scoring system predicts complications in pediatric CD and correlates with endoscopical and clinical scores. METHODS: We performed a retrospective study on 63 patients. Endoscopy in the time of diagnosis was evaluated using the Simple Endoscopic Score (SES) and histopathology with the Global Histology Activity Score, both in its original version (GHAS) and its modification (modGHAS)...
January 15, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28200166/response-to-the-letter-to-the-editor-risks-and-benefits-of-mucosal-healing-with-combined-immunosuppression-in-pediatric-crohn-s-disease-a-complex-topic-that-needs-careful-evaluation
#3
Federica Nuti, Fortunata Civitelli, Salvatore Cucchiara
No abstract text is available yet for this article.
February 15, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28193515/infliximab-not-associated-with-increased-risk-of-malignancy-or-hemophagocytic-lymphohistiocytosis-in-pediatric-patients-with-inflammatory-bowel-disease
#4
Jeffrey S Hyams, Marla C Dubinsky, Robert N Baldassano, Richard B Colletti, Salvatore Cucchiara, Johanna Escher, William Faubion, John Fell, Benjamin D Gold, Anne Griffiths, Sibylle Koletzko, Subra Kugathasan, James Markowitz, Frank M Ruemmele, Gigi Veereman, Harland Winter, Nicholas Masel, Chu Ri Shin, Kezhen L Tang, Meena Thayu
BACKGROUND AND AIMS: Immunosuppressive therapy for inflammatory bowel disease (IBD) in pediatric patients is thought to increase risk of malignancy and lymphoproliferative disorders, including hemophagocytic lymphohistiocytosis (HLH). We compared unadjusted incidence rates and of malignancy and HLH in pediatric patients with IBD exposed to infliximab compared with patients not exposed to biologics and calculated standardized incidence ratios (SIRs). METHODS: We collected and analyzed data from 5766 participants in a prospective study of long-term outcomes of pediatric patients with IBD (NCT00606346), from 2007 through 30 June 2016...
February 10, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28185689/imaging-of-acute-pelvic-pain-in-girls-ovarian-torsion-and-beyond-%C3%A2
#5
REVIEW
Lena Naffaa, Tejaswini Deshmukh, Shanthan Tumu, Chris Johnson, Kevin P Boyd, Arthur B Meyers
: Identifying the etiology of acute pelvic pain in girls is often clinically challenging. Particularly in young girls, it is often difficult to determine if acute pelvic symptoms are originating from a gynecologic source or from a genitourinary or gastrointestinal etiology based on the child's clinical examination alone. Therefore, imaging plays a key role in establishing a diagnosis and in directing medical and surgical treatment. Pediatric gynecologic conditions, which can present acutely with pain or mass or both include ovarian torsion, hematometrocolpos, pelvic inflammatory disease, inguinal hernias containing an ovary or the uterus or both, adnexal cysts, pregnancy, vaginal foreign bodies, and ovarian vein thrombosis...
December 21, 2016: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28180127/impact-of-fecal-calprotectin-measurement-on-decision-making-in-children-with-inflammatory-bowel-disease
#6
Wael El-Matary, Esmail Abej, Vini Deora, Harminder Singh, Charles N Bernstein
BACKGROUND: The use of fecal calprotectin (FCal) as a marker of intestinal inflammation, in the management of inflammatory bowel disease (IBD) is increasing. The aim of this study was to examine the impact of FCal measurements on decision-making and clinical care of children with IBD. MATERIALS AND METHODS: In a retrospective cohort study, FCal, clinical activity indices, and blood markers were measured in children with established diagnoses of IBD. Pearson correlation coefficient analysis was performed to examine association between FCal and other markers...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28178002/self-efficacy-and-resilience-are-useful-predictors-of-transition-readiness-scores-in-adolescents-with-inflammatory-bowel-diseases
#7
Katrine Carlsen, Nichola Haddad, Julia Gordon, Becky Lin Phan, Nanci Pittman, Keith Benkov, Marla C Dubinsky, Laurie Keefer
BACKGROUND: Adolescence is a vulnerable period for those afflicted with inflammatory bowel disease (IBD). There is limited knowledge of factors influencing transition readiness in this population. We sought to determine whether self-efficacy and resilience would be informative predictors of transition readiness independent of age. METHODS: Patients with IBD aged 16 to 23 years cared for in a pediatric setting were prospectively enrolled. On entry, patients filled out the Transition Readiness Assessment Questionnaire (TRAQ); IBD Self-Efficacy Scale-Adolescent (IBD-SES-A); and the Connor-Davidson Resilience Scale...
February 7, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28176348/inflammatory-bowel-diseases-in-faroese-born-danish-residents-and-their-offspring-further-evidence-of-the-dominant-role-of-environmental-factors-in-ibd-development
#8
T Hammer, S N Lophaven, K R Nielsen, M von Euler-Chelpin, P Weihe, P Munkholm, J Burisch, E Lynge
BACKGROUND: The incidence of inflammatory bowel disease (IBD) is record high in the Faroe Islands, and many Faroese emigrate to Denmark, where the IBD incidence is considerably lower. AIM: To study the IBD incidence in first-, second- and third-generation immigrants from the Faroe Islands to Denmark to assess the extent to which the immigrants adopt the lower IBD incidence of their new home country. METHODS: Data on Faroese-born Danish residents and their children were retrieved from the Danish Central Population Register for 1980-2014...
February 8, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28175006/dop057-perianal-pediatric-crohn-s-disease-is-associated-with-a-distinct-phenotype-and-greater-inflammatory-burden
#9
A Assa, M Amitai, M-L Greer, D Castro, R Cytter Kuint, M Martínez-Leόn, I Herman-Sucharska, E Coppenrath, S Anupindi, A Towbin, D Moote, O Konen, L-T Pratt, A Grifitths, D Turner
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174932/dop007-crohn-s-disease-exclusion-diet-and-partial-enteral-nutrition-cded-pen-vs-exclusive-enteral-nutrition-een-microbiome-changes-of-a-randomized-clinical-trial-rct-in-pediatric-cd-remission-is-associated-with-similar-structural-functional-profiles
#10
K A Dunn, R Sigall-Boneh, J P Bielawski, D Turner, J Van Limbergen, A Levine
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174747/a-disease-associated-microbial-and-metabolomics-state-in-relatives-of-pediatric-inflammatory-bowel-disease-patients
#11
Jonathan P Jacobs, Maryam Goudarzi, Namita Singh, Maomeng Tong, Ian H McHardy, Paul Ruegger, Miro Asadourian, Bo-Hyun Moon, Allyson Ayson, James Borneman, Dermot P B McGovern, Albert J Fornace, Jonathan Braun, Marla Dubinsky
BACKGROUND & AIMS: Microbes may increase susceptibility to inflammatory bowel disease (IBD) by producing bioactive metabolites that affect immune activity and epithelial function. We undertook a family based study to identify microbial and metabolic features of IBD that may represent a predisease risk state when found in healthy first-degree relatives. METHODS: Twenty-one families with pediatric IBD were recruited, comprising 26 Crohn's disease patients in clinical remission, 10 ulcerative colitis patients in clinical remission, and 54 healthy siblings/parents...
November 2016: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28173089/p775-fibre-intake-is-associated-with-microbiome-changes%C3%A2-in-pediatric-crohn-s-disease-patients-following-remission-induction-with-exclusive-enteral-nutrition
#12
A MacLellan, J Connors, B MacIntyre, G Douglas, K A Dunn, J P Bielawski, A Noble, G Mahdi, M Rashid, A R Otley, L Cahill, M G Langille, J Van Limbergen
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28173025/p484-dietary-therapy-using-the-crohn-s-disease-exclusion-diet-is-a-successful-strategy-for-induction-of-remission-in-children-and-adults-failing-biological-therapy
#13
R Sigall Boneh, C Sarbagili Shabat, M Boaz, A Levine, I Chermesh, S Ben Avraham, N Cohen Dolev
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172857/p147-metabolomics-discriminate-children-with-crohn-s-disease-from-ulcerative-colitis-and-from-healthy-controls-preliminary-study
#14
U Daniluk, M Ciborowski, J Daniluk, K Pietrowska, A Kretowski, D Lebensztejn
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172657/op025-evaluation-of-adalimumab-effectiveness-in-anti-tumor-necrosis-factor-na%C3%A3-ve-pediatric-patients-with-crohn-s-disease-in-clinical-practice
#15
S Steiner, E King, K Park, D Pashankar, H Shashidhar, B Sudel, S Eichner, S Chen, J Pratt, R Colletti
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28169974/f-calprotectin-and-blood-markers-correlate-to-quality-of-life-in-pediatric-inflammatory-bowel-disease
#16
Katrine Carlsen, Christian Jakobsen, Thomas Kallemose, Anders Paerregaard, Lene Buhl Riis, Pia Munkholm, Vibeke Wewer
OBJECTIVES: Our aim was to investigate predictors of Health Related Quality of Life (HRQoL) with respect to changes in disease parameters over time in children with Inflammatory Bowel Disease (IBD). METHODS: This was a prospective longitudinal study examining the association between HRQoL (IMPACT III) and symptom scores (PCDAI, abbrPUCAI), fecal calprotectin (FC) measures and blood analyses (C-reactive protein [CRP], erythrocyte sedimentation-rate [ESR], orosomucoid [ORM], albumin [ALB], hemoglobin [HB] and vitamin-D [VIT-D]) in a cohort of 10-17 years old IBD patients...
February 4, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28168734/new-onset-inflammatory-bowel-disease-in-adults-with-atopic-dermatitis
#17
Alexander Egeberg, Nita Wienholtz, Gunnar H Gislason, Lone Skov, Jacob P Thyssen
Atopic dermatitis (AD) is a common chronic and remitting inflammatory skin disease that affects children and adults. While some studies have reported an increased risk of Crohn's disease (CD), but not ulcerative colitis (UC), others have associated both conditions with AD. Notably, most studies have focused on IBD in childhood and adolescence. This article is protected by copyright. All rights reserved.
February 6, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28164626/expression-of-cd200r1-and-its-ligand-cd200-on-t-helper-lymphocytes-of-pediatric-patients-with-ulcerative-colitis-and-crohn-s-disease
#18
Mohamed F Elshal, Alia M Aldahlawi, Omar I Saadah, J Philip Mccoy
BACKGROUND: CD200 and its receptor CD200R are both type I membrane glycoproteins that modulate the activity of myeloid and lymphoid cells, and their interaction is functionally important in the suppression of effector T-cell responses by regulatory T-cells. We aimed to investigate the extent of expression of CD200 and CD200R1 on CD4+ T-cells in blood of children with ulcerative colitis (UC) and Crohn's disease (CD) and to explore their correlations with effector T cell subsets, regulatory T cells (Treg), and routine clinical and serological markers...
August 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28160250/thiopurines-and-methotrexate-use-in-ibd-patients-in-a-biologic-era
#19
REVIEW
Gerassimos J Mantzaris
Although we have been living in the era of biologic therapy for several decades, the use of immunomodulators (primarily thiopurines [azathioprine and mercaptopurine] and less so methotrexate) still remains an important component of the inflammatory bowel disease (IBD) pharmaceutical arsenal. Thiopurines as monotherapy exert corticosteroid-sparing effects and can maintain long-term remission in a considerable proportion of patients who have frequent relapses and are or have become mesalazine and/or corticosteroid intolerant or refractory...
February 3, 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28150131/inflammatory-bowel-disease-unclassified-in-children-diagnosis-and-pharmacological-management
#20
Giulia D'Arcangelo, Marina Aloi
Inflammatory bowel diseases are chronic disorders of the gastrointestinal tract that include Crohn's disease (CD), ulcerative colitis (UC) and inflammatory bowel disease-unclassified (IBDU). The latter defines a subgroup of patients with clinical and endoscopic evidence of chronic colitis, without specific features of either CD or UC. These patients will possibly be re-classified as having UC or CD during the follow-up, although a significant percentage of them will keep the diagnosis of IBDU. IBDU is the rarest subtype of IBD, both in children and in adults, although it is twice as common among the pediatric population, especially in the younger ages...
February 1, 2017: Paediatric Drugs
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