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Markus O Scheinhardt, Tamara Lerman, Inke R König, Georg Griesinger
STUDY QUESTION: What is the performance of previously established regression models in predicting low and high ovarian response to 150 μg corifollitropin alfa/GnRH-antagonist ovarian stimulation in an independent dataset? SUMMARY ANSWER: The outcome of ovarian stimulation with 150 μg corifollitropin alfa in a fixed, multiple dose GnRH-antagonist protocol can be validly predicted using logistic regression models with AMH being of paramount importance. WHAT IS KNOWN ALREADY: Predictors of ovarian response have been identified in FSH/GnRH agonist protocols as well as ovarian stimulation with corifollitropin alfa/GnRH-antagonist...
July 10, 2018: Human Reproduction
Mathew Parackal, Sherly Parackal
Public health messages are traditionally disseminated using mass media that typically are unidirectional or one-way communication. Consequent to the current media proliferation, two-way communication channels are also available for publishing health messages. Though they differ in operation, they co-exist which is explained by the media complementarity theory. This study reports research that identified the sources that women of childbearing age in New Zealand prefer when seeking information concerning alcohol and pregnancy...
July 10, 2018: Health Promotion International
Stephanie E Dreifuss, Danielle Minteer, Beth R Gusenoff, Jeffrey A Gusenoff
Background: Pedal fat grafting is a cosmetic procedure indicated to treat the functional and aesthetic sequelae of pedal fat pad atrophy. Fat grafting has been found to mitigate these symptoms, but the exact mechanism is unknown. Objectives: We hypothesize that pedal fat grafting may improve skin quality, accounting for prolonged symptomatic improvement despite loss of grafted fat. Methods: Patients with pedal atrophy were enrolled in a randomized crossover clinical trial...
July 10, 2018: Aesthetic Surgery Journal
Amira Elmadahm, Sarah J Lord, H Malcolm Hudson, Chee K Lee, Luke Buizen, Gelareh Farshid, Val J Gebski, P Grantley Gill
BACKGROUND: Sentinel lymph-node biopsy has reduced the need for extensive axillary surgery for staging. It still exposes women to associated morbidity. Risk models that use clinical and pathology information of the primary tumour to predict sentinel lymph-node metastasis may allow further improvements in care. This study assessed the performance of four published risk models for predicting sentinel lymph-node metastasis in Australian women with early breast cancer; including one model developed in an Australian population...
June 26, 2018: Breast: Official Journal of the European Society of Mastology
Waqar Haque, Vivek Verma, Sandra Hatch, V Suzanne Klimberg, E Brian Butler, Bin S Teh
PURPOSE: Multiple ongoing randomized studies are assessing the impact of omission of chemotherapy (CT) in low-risk node-positive Luminal A breast. The goal of this investigation was to evaluate trends and practice patterns of adjuvant CT use in Luminal A pT1-3N1 breast cancer, along with determining the clinical benefit from adjuvant CT in this patient population. METHODS: The National Cancer Data Base was queried (2004-2014) for women with pT1-3N1 luminal A invasive ductal carcinoma receiving adjuvant hormonal therapy (HT)...
July 2, 2018: Breast: Official Journal of the European Society of Mastology
Matteo Lambertini, Valeria Fontana, Claudia Massarotti, Francesca Poggio, Chiara Dellepiane, Giuseppina Iacono, Annalisa Abate, Loredana Miglietta, Chiara Ferreccio, Maria Carolina Pescio, Benedetta Conte, Eva Blondeaux, Claudia Bighin, Alessia D'Alonzo, Marina Vaglica, Elisa Zanardi, Francesco Boccardo, Alberto Ballestrero, Paola Anserini, Lucia Del Mastro
BACKGROUND: Despite the availability of different strategies for ovarian function and/or fertility preservation in young breast cancer patients candidates for chemotherapy, limited data are available on patients' actual need of these options. PATIENTS AND METHODS: The PREFER study is a prospective cohort study including premenopausal women with newly diagnosed early stage breast cancer between the age of 18 and 45 years and candidates for chemotherapy. The study aimed to investigate patients' preferences and their choices of the different available strategies for ovarian function and/or fertility preservation (i...
June 22, 2018: Breast: Official Journal of the European Society of Mastology
Iñaki Lete, Nicolás Mendoza, Esther de la Viuda, Francisco Carmona
OBJECTIVE: To assess the impact of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain on endometriosis-associated pelvic pain. STUDY DESIGN: Multicenter, open-label, non-comparative clinical trial in a representative sample of women with endometriosis-associated pelvic pain. RESULTS: In total, 398 patients with a mean age of 34.6 ± 7.2 years were treated with a combination of N-acetyl cysteine, alpha lipoic acid and bromelain for 6 months...
July 6, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Pradip Kumar Saha, Rashmi Bagga, Jasvinder Kaur Kalra, Aashima Arora, Rimpi Singla, Vanita Suri, Kajal Jain, Praveen Kumar, Nalini Gupta, Ashish Jain, Tulika Singh, Ravimohan S Mavuduru
BACKGROUND: Cesarean hysterectomy for adherent placenta is associated with increased maternal morbidity due to massive hemorrhage requiring large volume blood transfusion, bladder or ureteric injury, intensive care unit (ICU) admission and prolonged hospital stay. There is an ongoing effort to improve the outcome of these women and measures to reduce blood loss. OBJECTIVE: The purpose of the present study was to develop an alternate surgical approach for performing a Cesarean hysterectomy in women with adherent placenta in order to reduce hemorrhage and urinary tract injuries, and thereby improve the maternal outcome...
July 4, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
G J Waring, S Shawer, K Hinshaw
O-ring retractors (Alexis/Mobius) have been shown to reduce the risk of Surgical site infection (SSI) following general abdominal surgery. The benefit at caesarean section (CS) remains to be established given the relatively high cost. OBJECTIVES: To assess the efficacy of O-ring retractors when used at CS. STUDY DESIGN: Systematic review and meta-analysis. Electronic databases were searched from inception of each database until January 2018. No language restrictions were applied...
June 25, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Anne Eskild, Lars Monkerud, Anne Marie Jukic, Bjørn Olav Åsvold, Kari Kveim Lie
BACKGROUND: Intrauterine conditions may be important in the development of cerebral palsy in the child. The hormone, human chorionic gonadotropin (hCG), is synthesized in the placenta, and hCG plays an important role in placental angiogenesis and development. Thus, maternal hCG concentrations may be an indicator of placental function and thereby the intrauterine environment for the offspring. We studied the associations of maternal concentrations of hCG during pregnancy with cerebral palsy in the child...
July 4, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Jiaqiang Liao, Huifang Yu, Wei Xia, Bin Zhang, Bin Lu, Zhongqiang Cao, Shengwen Liang, Ke Hu, Shunqing Xu, Yuanyuan Li
BACKGROUND: Gestational weight gain (GWG) is increasingly reported to be associated with adverse birth outcomes. However, the effect of PM2.5 exposure during pregnancy on GWG is unknown. OBJECTIVES: We investigated the associations between the exposure to PM2.5 and GWGs during three pregnancy trimesters based on a prospective birth cohort. METHODS: Data were obtained from 2029 pregnant women who participated in a birth cohort between January 2013 and October 2014 in Wuhan, China...
July 11, 2018: Environment International
Erik Landfeldt, Anna Castelo-Branco, Axel Svedbom, Emil Löfroth, Andrius Kavaliunas, Jan Hillert
BACKGROUND: Several studies have investigated the impact of multiple sclerosis (MS) on the risk of divorce. However, current evidence is inconclusive and limited by e.g. small sample populations, short follow-up, and/or lack of a control group. The objective of this retrospective, observational study was to estimate the long-term impact of MS on the risk of divorce. METHODS: Swedish patients diagnosed with MS between 1975 and 2012 were identified in a nationwide disease-specific register (the Swedish Multiple Sclerosis Registry) and matched with general population controls based on age, sex, region of residency, and marital status...
July 3, 2018: Multiple Sclerosis and related Disorders
Anna Maisa, Sarah Milligan, Alison Quinn, Denise Boulter, Jillian Johnston, Charlene Treanor, Declan T Bradley
OBJECTIVES: Influenza and pertussis vaccination programmes have been in place for pregnant women in the UK since 2009 and 2012, respectively. In 2015, vaccine uptake rates were 55% for influenza and 63% for pertussis in Northern Ireland. We conducted a qualitative study with the aim of learning about the views of pregnant women and identifying potential barriers to vaccination in pregnancy. STUDY DESIGN: Qualitative study using focus groups and in-depth interviews...
July 11, 2018: Public Health
Charalambos Hadjigeorgiou, Antonia Solea, Sara Estecha Querol, Anna Keski-Rahkonen, Nathalie Michels, Paola Russo, Barbara Franziska Thumann, Valeria Pala, Unna Danner
OBJECTIVE: The objective of this study was to evaluate disordered eating behaviours (DEBs) in different age groups in a Cypriot non-clinical population sample. STUDY DESIGN: Comparative cross-sectional study. METHOD: A total of 1716 participants from the Cyprus component of the I.Family study completed the Eating Attitudes Test-26 (EAT-26). The EAT-26 score ≥20 was used to define participants at risk for DEBs. Participants were divided according to age: adolescence (12-18 years old), young adulthood (25-45 years old) and middle adulthood (46-60 years old)...
July 9, 2018: Public Health
Eileen K Hutton, Mary E Hannah, Andrew R Willan, Susan Ross, Alexander C Allen, B Anthony Armson, Amiram Gafni, K S Joseph, Kathryn Mangoff, Arne Ohlsson, J Johanna Sanchez, Elizabeth V Asztalos, Jon F R Barrett
OBJECTIVE: Does planned caesarean compared with planned vaginal birth lower the risk of problematic urinary stress, fecal or flatal incontinence?. DESIGN: Women between 32 0/7 and 38 6/7 weeks gestation with twin pregnancy were randomised to planned caesarean or planned vaginal birth. SETTING: 106 centers in 25 countries. POPULATION: 2305 /2804 enrolled in the study completed questionnaires at two years (82.2%follow up): 1155 in the planned caesarean group, 1150 in the planned vaginal birth group...
July 14, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
R M Tähtinen, R Cartwright
Stress urinary incontinence is a common condition among women. Although an extensive body of evidence suggests that vaginal delivery increases rates of post-partum stress urinary incontinence compared with caesarean section (Tähtinen RM et al. Eur Urol. 2016;70:148-58) there has been almost an complete lack of adequate prior RCT data. The only previous randomized trial to address this topic is the Term Breech Trial (Hannah M et al. Am J Obstet Gynecol.2004;191:917-27). This article is protected by copyright...
July 14, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
Yvonne Rosalie Elisabeth Skogsdal, Jan Åke Karlsson, Yang Cao, Helena Elisabeth Fadl, Tanja Adele Tydén
INTRODUCTION: Limited attention has been paid to the use of contraception in relation to women's family planning intentions. The aim of this study was to investigate the use of contraception during the most recent intercourse as well as the reproductive intentions of Swedish speaking women requesting contraceptive counseling. MATERIAL AND METHODS: A cross-sectional baseline survey in a randomized controlled trial regarding reproductive life planning (before randomization)...
July 14, 2018: Acta Obstetricia et Gynecologica Scandinavica
Nina Julie Verket, Till Uhlig, Leiv Sandvik, Marit Helen Andersen, Tom Gunnar Tanbo, Erik Qvigstad
INTRODUCTION: Women with endometriosis have reduced health-related quality of life (HRQoL). However, comparisons to the general population and other patient groups are lacking. MATERIAL AND METHODS: The present cross-sectional questionnaire study included 157 women with endometriosis, 156 women from the general population, and 837 women with rheumatoid arthritis (RA). During a period from 2012 to 2013, women aged 18-45 years were recruited from the Norwegian Endometriosis Association and from a random sample of women residing in Oslo, Norway...
July 14, 2018: Acta Obstetricia et Gynecologica Scandinavica
Patricia G Oppelt, Meike Weber, Andreas Mueller, Alexander Boosz, Inge Hoffmann, Nathalie Raffel, Laura Lotz, Matthias W Beckmann, Ralf Dittrich
INTRODUCTION: Endometriosis is associated with hyperperistalsis and dysperistalsis in the uterus, and it has been shown that progesterone leads to a decrease in uterine contractility. The synthetic gestagen dienogest is often administered in women who are receiving conservative treatment for endometriosis, and it may be the treatment of choice. The present study investigated the effects of dienogest on uterine contractility in comparison with the known inhibitory effect of progesterone...
July 14, 2018: Acta Obstetricia et Gynecologica Scandinavica
Shannon Reid, Mercedes Espada, Chuan Lu, George Condous
INTRODUCTION: The study aim was to evaluate the transvaginal sonography (TVS) "sliding sign" alone, direct visualization of the bowel with TVS, and the combination of both methods (i.e. "sliding sign" and direct visualization of the bowel), to determine the optimal TVS method for the prediction of rectal/rectosigmoid deep endometriosis (DE). MATERIAL AND METHODS: Multicentre prospective observational study (January 2009- February 2017). All women underwent TVS to determine whether the "sliding sign" was positive/negative and whether rectal/rectosigmoid DE was present, followed by laparoscopic surgery...
July 14, 2018: Acta Obstetricia et Gynecologica Scandinavica
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