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https://www.readbyqxmd.com/read/28927243/early-endometriosis-in-females-is-directed-by-immune-mediated-estrogen-receptor-alpha-and-il6-cross-talk
#1
Katherine A Burns, Seddon Y Thomas, Katherine J Hamilton, Steven L Young, Donald N Cook, Kenneth S Korach
Endometriosis is a gynecological disease that negatively affects the health of 1 in 10 women. While more information is known about late stage disease, the early initiation of endometriosis and lesion development is poorly understood. Herein, we use a uterine tissue transfer mouse model of endometriosis to examine early disease development and its dependence on estradiol (E2) and estrogen receptor a (ERα) within 72 h of disease initiation. Using wild type and ERα knockout mice as hosts or donors, we find significant infiltration of neutrophils and macrophages into the peritoneal cavity...
September 11, 2017: Endocrinology
https://www.readbyqxmd.com/read/28927191/increasing-mortality-from-ischaemic-heart-disease-in-china-from-2004-to-2010-disproportionate-rise-in-rural-areas-and-elderly-subjects-438-million-person-years-follow-up
#2
Xiaofei Zhang, Arshad A Khan, Ehtesham Ul Haq, Aadil Rahim, Dayi Hu, John Attia, Christopher Oldmeadow, Xiaoyan Ma, Rongjing Ding, Andrew J Boyle
Aims: We sought to ascertain the changes in mortality from ischaemic heart disease (IHD) from 2004 to 2010 in China as the sheer size of China's population makes disease patterns relevant globally. Methods and results: Data on IHD mortality were obtained from the Chinese Centre for Disease Control and Prevention National Disease Surveillance Point System, which includes 161 counties and a population of over 73 million-a representative sample of over 6% of the entire population of China...
January 1, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/28927096/laptm4b-2-allele-is-associated-with-the-development-of-papillary-thyroid-carcinoma-in-chinese-women
#3
Yue Meng, Rouli Zhou, Jianjun Xu, Qingyun Zhang
Lysosome-associated protein transmembrane 4-β (LAPTM4B) contains a polymorphic region that contributes to the increased risk of numerous types of tumor. However, no study has yet demonstrated an association between the expression of the LAPTM4B gene and tumor differentiation, and the reason that LAPTM4B polymorphisms affect the susceptibility of individuals to cancer remains to be elucidated. The present study assessed the possible association between LAPTM4B polymorphism and the risk of papillary thyroid carcinoma (PTC), and attempted to identify the underlying mechanism for variation in patient susceptibility with respect to transcription regulation in the polymorphism region...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927094/genomic-markers-of-ovarian-adenocarcinoma-and-its-relevancy-to-the-effectiveness-of-chemotherapy
#4
Monika Englert-Golon, Bartosz Burchardt, Bartlomiej Budny, Szymon Dębicki, Blanka Majchrzycka, Elzbieta Wrotkowska, Piotr Jasiński, Katarzyna Ziemnicka, Radosław Słopień, Marek Ruchała, Stefan Sajdak
Ovarian cancer is the eighth most common cancer and the seventh highest cause of cancer-associated mortality in women worldwide. It is the second highest cause of mortality among female reproductive malignancies. The current standard first-line treatment for advanced ovarian cancer includes a combination of surgical debulking and standard systemic platinum-based chemotherapy with carboplatin and paclitaxel. Although a deeper understanding of this disease has been attained, relapse occurs in 70% of patients 18 months subsequent to the first-line treatment...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927084/thalidomide-and-lenalidomide-for-recurrent-ovarian-cancer-a-systematic-review-of-the-literature
#5
Clemens B Tempfer, Beate Schultheis, Ziad Hilal, Askin Dogan, Günther A Rezniczek
The present review aimed to assess the safety and efficacy of thalidomide and lenalidomide, two immunomodulatory drugs with anti-angiogenic properties, in women with recurrent ovarian, fallopian tube, and primary peritoneal cancer. A systematic review of the literature was conducted whereby Medline and the Cochrane Central Register of Controlled Trials were searched using terms associated with thalidomide, lenalidomide, and recurrent ovarian, fallopian tube and primary peritoneal cancer. Published English language case reports, trials and studies that described the safety and efficacy of thalidomide or lenalidomide alone, or in combination with other drugs were reviewed...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927063/microrna-494-is-a-potential-prognostic-marker-and-inhibits-cellular-proliferation-migration-and-invasion-by-targeting-sirt1-in-epithelial-ovarian-cancer
#6
Aijun Yang, Xuenan Wang, Chunna Yu, Zhenzhen Jin, Lingxia Wei, Jinghe Cao, Qin Wang, Min Zhang, Lin Zhang, Lei Zhang, Cuifang Hao
Ovarian cancer is one of the most common types of gynecological malignancy worldwide, and is the fourth leading cause of cancer-associated mortality among women. Despite improvements in therapeutic treatments, the prognosis for epithelial ovarian cancer (EOC) remains poor, mainly due to the rapid growth and metastasis of ovarian cancer tumors. An increasing number of studies have indicated that microRNAs (miRNAs) are involved in the carcinogenesis and progression of human cancer, suggesting that miRNAs may be used in clinical prognosis and as a therapeutic target in EOC...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927014/green-space-and-depression-during-pregnancy-results-from-the-growing-up-in-new-zealand-study
#7
Vikram Nichani, Kim Dirks, Bruce Burns, Amy Bird, Cameron Grant
Background: Antenatal depression is an important contributor to poor maternal health experienced by some women. This study aimed to determine whether exposure to green space during pregnancy is associated with less depression, and whether this association is moderated by relevant factors, such as age, education, self-identified ethnicity, physical activity, residential rurality, and socioeconomic status. Methods: Health data were sourced from the cohort study "Growing Up in New Zealand" comprised of 6772 participants...
September 18, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28926979/mother-s-ipv-child-maltreatment-type-and-the-presence-of-ptsd-in-children-and-adolescents
#8
Maravillas Castro, Mavi Alcántara-López, Antonia Martínez, Visitación Fernández, Julio Sánchez-Meca, Concepción López-Soler
This correlational cross-sectional study was designed to investigate whether the intimate partner violence (IPV) suffered by mothers (physical and psychological maltreatment), child eyewitness of psychological and physical maltreatment suffered by the mother, the neglect suffered by children, and the maltreatment (physical and psychological) directly suffered by children are statistically associated to post-traumatic stress disorder (PTSD) symptoms exhibited by the child. In addition, the prevalence of child PTSD was estimated, as well as the concordance between the PTSD symptoms assessed by the Child PTSD Symptom Scale (CPSS) and the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) criteria for child PTSD...
September 17, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28926945/association-between-dietary-carotenoid-intake-and-bone-mineral-density-in-korean-adults-aged-30-75-years-using-data-from-the-fourth-and-fifth-korean-national-health-and-nutrition-examination-surveys-2008-2011
#9
Gebereamanuel Meron Regu, Hyesook Kim, You Jin Kim, Ju Eun Paek, Gunjeong Lee, Namsoo Chang, Oran Kwon
Age-related bone loss is a major public health problem. This cross-sectional study examined the association between the dietary intake of carotenoids and bone mineral density (BMD). Data from 8022 subjects (3763 males and 4259 females) aged 30-75 years included in the Korean National Health and Nutrition Examination Survey (2008-2011) were analyzed. BMD was measured by dual-energy X-ray absorptiometry. Intake of carotenoids was estimated using 24-h dietary recall. In multiple linear analysis, after adjusting for covariates, lutein + zeaxanthin and β-cryptoxanthin intake was positively associated with total hip BMD in males and premenopausal women respectively, while β-carotene intake was positively correlated with femoral neck, total hip, and whole-body BMD in postmenopausal women...
September 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28926937/food-shopping-and-acquisition-behaviors-in-relation-to-bmi-among-residents-of-low-income-communities-in-south-carolina
#10
Angela D Liese, Xiaonan Ma, Brent Hutto, Patricia A Sharpe, Bethany A Bell, Sara Wilcox
Low-income areas in which residents have poor access to healthy foods have been referred to as "food deserts." It is thought that improving food access may help curb the obesity epidemic. Little is known about where residents of food deserts shop and if shopping habits are associated with body mass index (BMI). We evaluated the association of food shopping and acquisition (e.g., obtaining food from church, food pantries, etc.) with BMI among 459 residents of low-income communities from two South Carolina counties, 81% of whom lived in United States Department of Agriculture-designated food deserts...
September 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28926936/relationships-of-sexual-dysfunction-with-depression-and-acceptance-of-illness-in-women-and-men-with-type-2-diabetes-mellitus
#11
Ewelina Bąk, Czeslaw Marcisz, Sylwia Krzemińska, Dorota Dobrzyn-Matusiak, Agnieszka Foltyn, Agnieszka Drosdzol-Cop
An increased prevalence of sexual disorders has been reported in patients with type 2 diabetes. The aim of this study is the assessment of the influence of the psychical condition, the concentration of glycated hemoglobin, the duration of diabetes, the body mass index, the age, and the subjective acceptance of the illness on sexual disorders occurring in women and men with type 2 diabetes. The study enrolled 215 patients (114 women and 101 men) with type 2 diabetes and 183 controls. Sexuality was determined in all of the studied subjects using: the Female Sexual Function Index (FSFI) in women and the International Index of Erectile Function (IIEF) in men...
September 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28926932/comparison-of-two-components-of-propolis-caffeic-acid-ca-and-caffeic-acid-phenethyl-ester-cape-induce-apoptosis-and-cell-cycle-arrest-of-breast-cancer-cells-mda-mb-231
#12
Agata Kabała-Dzik, Anna Rzepecka-Stojko, Robert Kubina, Żaneta Jastrzębska-Stojko, Rafał Stojko, Robert Dariusz Wojtyczka, Jerzy Stojko
Studies show that caffeic acid (CA) and caffeic acid phenethyl ester (CAPE) are compounds with potent chemopreventive effects. Breast cancer is a common form of aggressive cancer among women worldwide. This study shows a comparison of CA and CAPE activity on triple-negative human caucasian breast adenocarcinoma line cells (MDA-MB-231). MDA-MB-231 cells were treated by CA and CAPE with doses of from 10 to 100 µM, for periods of 24 h and 48 h. Cytotoxicity MTT tests, apoptosis by Annexin V, and cell cycle with Dead Cell Assays were performed...
September 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28926931/comparison-of-sociodemographic-and-nutritional-characteristics-between-self-reported-vegetarians-vegans-and-meat-eaters-from-the-nutrinet-sant%C3%A3-study
#13
Benjamin Allès, Julia Baudry, Caroline Méjean, Mathilde Touvier, Sandrine Péneau, Serge Hercberg, Emmanuelle Kesse-Guyot
BACKGROUND: There is a growing trend for vegetarian and vegan diets in many Western countries. Epidemiological evidence suggesting that such diets may help in maintaining good health is rising. However, dietary and sociodemographic characteristics of vegetarians and vegans are not well known. The aim of this cross-sectional study was to describe sociodemographic and nutritional characteristics of self-reported, adult vegetarians and vegans, compared to meat-eaters, from the French NutriNet-Santé study...
September 15, 2017: Nutrients
https://www.readbyqxmd.com/read/28926826/a-low-cerebroplacental-ratio-at-20-24-weeks-of-gestation-can-predict-reduced-fetal-size-later-in-pregnancy-or-at-birth
#14
Edgar Hernandez-Andrade, Eli Maymon, Offer Erez, Homam Saker, Suchaya Luewan, Maynor Garcia, Hyunyoung Ahn, Adi L Tarca, Bogdan Done, Steven J Korzeniewski, Sonia S Hassan, Roberto Romero
AIM: To determine whether Doppler evaluation at 20-24 weeks of gestation can predict reduced fetal size later in pregnancy or at birth. METHODS: Fetal biometry and Doppler velocimetry were performed in 2,986 women with a singleton pregnancy at 20-24 weeks of gestation. Predictive performances of the umbilical artery pulsatility index (UA-PI) or the mean uterine artery pulsatility index (UtA-PI) >95th percentile, middle cerebral artery pulsatility index, or cerebroplacental ratio (CPR) <5th percentile for early small for gestational age (SGA; <34 weeks of gestation), late SGA (≥34 weeks of gestation), or SGA at birth (birthweight <10th percentile) were analyzed...
September 20, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28926815/cognitive-function-and-walking-velocity-in-people-with-dementia-a-comparison-of-backward-and-forward-walking
#15
Hanna Johansson, Lillemor Lundin-Olsson, Håkan Littbrand, Yngve Gustafson, Erik Rosendahl, Annika Toots
How forward and backward walking, both central to everyday life, relate to cognition are relatively unexplored in people with dementia. This study aimed to investigate if forward and backward walking velocity respectively, associated with global cognition and executive function in people with dementia, and whether the association differed according to walking aid use or dementia type. Using a cross-sectional design, 161 participants (77% women), a mean Mini-Mental State Examination (MMSE) score of 15, and mean age of 85...
September 9, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28926807/ambient-temperature-and-risk-of-cardiovascular-events-at-labor-and-delivery-a-case-crossover-study
#16
Sandie Ha, Kelly Nguyen, Danping Liu, Tuija Männistö, Carrie Nobles, Seth Sherman, Pauline Mendola
BACKGROUND: Extreme ambient temperatures are linked to cardiac events in the general population, but this relationship is unclear among pregnant women. We estimated the associations and attributable risk between ambient temperature and the risk of cardiovascular event at labor/delivery, and investigated whether these associations vary by maternal race/ethnicity. METHODS: We identified 680 women with singleton deliveries affected by cardiovascular events across 12 US sites (2002-2008)...
September 16, 2017: Environmental Research
https://www.readbyqxmd.com/read/28926777/experience-as-knowledge-disability-distillation-and-reprogenetic-decision-making
#17
Felicity K Boardman
'Experiential knowledge' is increasingly recognised as an important influence on reproductive decision-making. 'Experiential knowledge of disability' in particular is a significant resource within prenatal testing/screening contexts, enabling prospective parents to imagine and appraise future lives affected by disability. However, the concept of 'experiential knowledge' has been widely critiqued for its idiosyncrasy, its impermanence and consequently its perceived inferiority to (medical) knowledge. This paper explores some of these key critiques of experiential knowledge through an analysis of its constitution and uses in the context of reproductive decision-making...
September 8, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28926775/geographic-and-demographic-correlates-of-autism-related-anti-vaccine-beliefs-on-twitter-2009-15
#18
Theodore S Tomeny, Christopher J Vargo, Sherine El-Toukhy
This study examines temporal trends, geographic distribution, and demographic correlates of anti-vaccine beliefs on Twitter, 2009-2015. A total of 549,972 tweets were downloaded and coded for the presence of anti-vaccine beliefs through a machine learning algorithm. Tweets with self-disclosed geographic information were resolved and United States Census data were collected for corresponding areas at the micropolitan/metropolitan level. Trends in number of anti-vaccine tweets were examined at the national and state levels over time...
September 4, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28926762/progesterone-for-smoking-relapse-prevention-following-delivery-a-pilot-randomized-double-blind-study
#19
Ariadna Forray, Kathryn Gilstad-Hayden, Cristine Suppies, Debra Bogen, Mehmet Sofuoglu, Kimberly A Yonkers
INTRODUCTION: Close to half of women who were smokers prior to conception quit smoking in pregnancy, when endogenous progesterone levels are high. However, at least half resume pre-pregnancy smoking levels within weeks after delivery and when progesterone levels drop. The current pilot study tested the feasibility and preliminary efficacy of postpartum progesterone replacement in preventing relapse to smoking in postpartum women with a history of pre-pregnancy smoking. METHODS: This was an 8-week, double-blind, parallel, randomized, placebo-controlled pilot trial of 41 women with a history of pre-pregnancy smoking who achieved abstinence by 32 weeks of gestation...
September 14, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28926745/microrna-30e-functions-as-a-tumor-suppressor-in-cervical-carcinoma-cells-through-targeting-galnt7
#20
Huijuan Wu, Jun Chen, Dan Li, Xiangyu Liu, Lei Li, Ke Wang
Cervical cancer is the third most common cancer in women worldwide. However, the underlying mechanism of occurrence and development of cervical cancer is obscure. In this study, we observed that miR-30e was downregulated in clinical cervical cancer tissues and cervical cancer cells. Next, overexpression of miR-30e reduced the cervical cancer cell growth through MTT, colony formation, EdU, and Transwell assay in SiHa and Caski cells. Subsequently, UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7 (GALNT7) was identified as a potential miR-30e target by bioinformatics analysis...
September 16, 2017: Translational Oncology
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