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Breast cancer and early adulthood

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https://www.readbyqxmd.com/read/27825136/pubertal-and-adult-windows-of-susceptibility-to-a-high-animal-fat-diet-in-trp53-null-mammary-tumorigenesis
#1
Yirong Zhu, Mark D Aupperlee, Yong Zhao, Ying Siow Tan, Erin L Kirk, Xuezheng Sun, Melissa A Troester, Richard C Schwartz, Sandra Z Haslam
Premenopausal breast cancer is associated with increased animal fat consumption among normal weight, but not overweight women (Farvid et al., 2014). Our previous findings in obesity-resistant BALB/c mice similarly showed promotion of carcinogen-induced mammary tumorigenesis by a diet high in saturated animal fat (HFD). This effect was specific to pubertal versus adult HFD. This study identifies the effects of HFD during puberty versus adulthood in Trp53-null transplant BALB/c mice and investigates its mechanism of enhancing tumorigenesis...
November 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27796946/overview-of-mammary-gland-development-a-comparison-of-mouse-and-human
#2
Sara McNally, Torsten Stein
The mouse mammary gland is widely used as a model for human breast cancer and has greatly added to our understanding of the molecular mechanisms involved in breast cancer development and progression. To fully appreciate the validity and limitations of the mouse model, it is essential to be aware of the similarities and also the differences that exist between the mouse mammary gland and the human breast. This introduction therefore describes the parallels and contrasts in mouse mammary gland and human breast morphogenesis from an early embryonic phase through to puberty, adulthood, pregnancy, parturition, and lactation, and finally the regressive stage of involution...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27765796/early-life-residence-fish-consumption-and-risk-of-breast-cancer
#3
Alfheidur Haraldsdottir, Laufey Steingrimsdottir, Unnur Valdimarsdottir, Thor Aspelund, Laufey Tryggvadottir, Tamara B Harris, Lenore Launer, Lorelei A Mucci, Edward L Giovannucci, Hans-Olov Adami, Vilmundur Gudnason, Johanna E Torfadottir
BACKGROUND: Little is known about fish intake throughout the life course and the risk of breast cancer. METHODS: We used data on the first residence of 9,340 women born 1908-1935 in the Reykjavik Study as well as food frequency data for different periods of life from a subgroup of the cohort entering the AGES-Reykjavik Study (n = 2,882). RESULTS: During a mean follow-up of 27.3 years, 744 women were diagnosed with breast cancer in the Reykjavik Study...
October 10, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27549771/endometriosis-and-mammographic-density-measurements-in-the-nurses-health-study-ii
#4
Leslie V Farland, Rulla M Tamimi, A Heather Eliassen, Donna Spiegelman, Kimberly A Bertrand, Stacey A Missmer
PURPOSE: Endometriosis and mammographic density have been hypothesized to be influenced by sex steroid hormonal exposures in adolescence and early adulthood. We investigated the association between endometriosis and mammographic density, a consistent and independent risk factor for breast cancer. METHODS: We conducted a cross-sectional analysis among 1,581 pre- and postmenopausal women not previously diagnosed with breast cancer in the Nurses' Health Study II cohort...
October 2016: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/27529652/duration-of-adulthood-overweight-obesity-and-cancer-risk-in-the-women-s-health-initiative-a-longitudinal-study-from-the-united-states
#5
Melina Arnold, Luohua Jiang, Marcia L Stefanick, Karen C Johnson, Dorothy S Lane, Erin S LeBlanc, Ross Prentice, Thomas E Rohan, Beverly M Snively, Mara Vitolins, Oleg Zaslavsky, Isabelle Soerjomataram, Hoda Anton-Culver
BACKGROUND: High body mass index (BMI) has become the leading risk factor of disease burden in high-income countries. While recent studies have suggested that the risk of cancer related to obesity is mediated by time, insights into the dose-response relationship and the cumulative impact of overweight and obesity during the life course on cancer risk remain scarce. To our knowledge, this study is the first to assess the impact of adulthood overweight and obesity duration on the risk of cancer in a large cohort of postmenopausal women...
August 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27510186/lifetime-grain-consumption-and-breast-cancer-risk
#6
Maryam S Farvid, Eunyoung Cho, A Heather Eliassen, Wendy Y Chen, Walter C Willett
We evaluated individual grain-containing foods and whole and refined grain intake during adolescence, early adulthood, and premenopausal years in relation to breast cancer risk in the Nurses' Health Study II. Grain-containing food intakes were reported on a baseline dietary questionnaire (1991) and every 4 years thereafter. Among 90,516 premenopausal women aged 27-44 years, we prospectively identified 3235 invasive breast cancer cases during follow-up to 2013. 44,263 women reported their diet during high school, and from 1998 to 2013, 1347 breast cancer cases were identified among these women...
September 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27496084/risks-of-first-and-subsequent-cancers-among-tp53-mutation-carriers-in-the-national-cancer-institute-li-fraumeni-syndrome-cohort
#7
Phuong L Mai, Ana F Best, June A Peters, Rosamma M DeCastro, Payal P Khincha, Jennifer T Loud, Renée C Bremer, Philip S Rosenberg, Sharon A Savage
BACKGROUND: Li-Fraumeni syndrome (LFS) is an autosomal dominant cancer predisposition syndrome characterized by a very high lifetime cancer risk and an early age at diagnosis of a wide cancer spectrum. Precise estimates for the risk of first and subsequent cancers are lacking. METHODS: The National Cancer Institute's Li-Fraumeni Syndrome Study includes families meeting the diagnostic criteria for LFS or Li-Fraumeni-like syndrome, and individuals with a germline TP53 mutation, choroid plexus carcinoma, adrenocortical carcinoma, or ≥3 cancers...
December 1, 2016: Cancer
https://www.readbyqxmd.com/read/27170029/fruit-and-vegetable-consumption-in-adolescence-and-early-adulthood-and-risk-of-breast-cancer-population-based-cohort-study
#8
Maryam S Farvid, Wendy Y Chen, Karin B Michels, Eunyoung Cho, Walter C Willett, A Heather Eliassen
OBJECTIVE:  To evaluate the association between fruit and vegetable intake during adolescence and early adulthood and risk of breast cancer. DESIGN:  Prospective cohort study. SETTING:  Health professionals in the United States. PARTICIPANTS:  90 476 premenopausal women aged 27-44 from the Nurses' Health Study II who completed a questionnaire on diet in 1991 as well as 44 223 of those women who completed a questionnaire about their diet during adolescence in 1998...
May 11, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27042159/weight-loss-reduces-basal-like-breast-cancer-through-kinome-reprogramming
#9
Yuanyuan Qin, Sneha Sundaram, Luma Essaid, Xin Chen, Samantha M Miller, Feng Yan, David B Darr, Joseph A Galanko, Stephanie A Montgomery, Michael B Major, Gary L Johnson, Melissa A Troester, Liza Makowski
BACKGROUND: Obesity is associated with an aggressive subtype of breast cancer called basal-like breast cancer (BBC). BBC has no targeted therapies, making the need for mechanistic insight urgent. Reducing adiposity in adulthood can lower incidence of BBC in humans. Thus, this study investigated whether a dietary intervention to reduce adiposity prior to tumor onset would reverse HFD-induced BBC. METHODS: Adult C3(1)-Tag mice were fed a low or high fat diet (LFD, HFD), and an obese group initially exposed to HFD was then switched to LFD to induce weight loss...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27006379/effects-of-pubertal-exposure-to-dietary-soy-on-estrogen-receptor-activity-in-the-breast-of-cynomolgus-macaques
#10
Fitriya N Dewi, Charles E Wood, Cynthia J Willson, Thomas C Register, Cynthia J Lees, Timothy D Howard, Zhiqing Huang, Susan K Murphy, Janet A Tooze, Jeff W Chou, Lance D Miller, J Mark Cline
Endogenous estrogens influence mammary gland development during puberty and breast cancer risk during adulthood. Early-life exposure to dietary or environmental estrogens may alter estrogen-mediated processes. Soy foods contain phytoestrogenic isoflavones (IF), which have mixed estrogen agonist/antagonist properties. Here, we evaluated mammary gland responses over time in pubertal female cynomolgus macaques fed diets containing either casein/lactalbumin (n = 12) or soy protein containing a human-equivalent dose of 120 mg IF/day (n = 17) for approximately 4...
May 2016: Cancer Prevention Research
https://www.readbyqxmd.com/read/26908709/dietary-fiber-intake-in-young-adults-and-breast-cancer-risk
#11
Maryam S Farvid, A Heather Eliassen, Eunyoung Cho, Xiaomei Liao, Wendy Y Chen, Walter C Willett
OBJECTIVE: We evaluated fiber intake during adolescence and early adulthood in relation to breast cancer (BC) risk in the Nurses' Health Study II. METHODS: Among 90,534 premenopausal women who completed a dietary questionnaire in 1991, we documented 2833 invasive BC cases during 20 years of follow-up. In 1998, 44,263 of these women also completed a questionnaire about their diet during high school; among these women, we documented 1118 cases of BC by end of follow-up...
March 2016: Pediatrics
https://www.readbyqxmd.com/read/26830901/alcohol-intake-from-early-adulthood-to-midlife-and-mammographic-density
#12
Jasmine A McDonald, Karin B Michels, Barbara A Cohn, Julie D Flom, Parisa Tehranifar, Mary Beth Terry
PURPOSE: Moderate alcohol consumption (15 g/day) has been consistently associated with increased breast cancer risk; however, the association between alcohol and mammographic density, a strong marker of breast cancer risk, has been less consistent. Less is known about the effect of patterns of alcohol intake across the lifecourse. METHODS: Using the Early Determinants of Mammographic Density study, an adult follow-up of women born in two US birth cohorts (n = 697; Collaborative Perinatal Project in Boston and Providence sites and the Childhood Health and Development Studies in California), we examined the association between alcohol intake in early adulthood (ages 20-29 years) and at time of interview and mammographic density (percent density and total dense area)...
April 2016: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/26613540/perinatal-and-childhood-factors-and-risk-of-breast-cancer-subtypes-in-adulthood
#13
Virginia Lope, Esther García-Esquinas, Beatriz Pérez-Gómez, Jone M Altzibar, Esther Gracia-Lavedan, María Ederra, Antonio José Molina de la Torre, Francisco Javier LLorca, Adonina Tardón, Víctor Moreno, Juan Bayo, Dolores Salas-Trejo, Rafael Marcos-Gragera, José Pumarega, Trinidad Dierssen-Sotos, Juan Pablo Barrio Lera, M A Concepción de Miguel Medina, Ignasi Tusquets, Pilar Amiano, Elena Boldo, Manolis Kogevinas, Nuria Aragonés, Gemma Castaño-Vinyals, Marina Pollán
BACKGROUND: Accumulated exposure to hormones and growth factors during early life may influence the future risk of breast cancer (BC). This study examines the influence of childhood-related, socio-demographic and anthropometric variables on BC risk, overall and by specific pathologic subtypes. METHODS: This is a case-control study where 1539 histologically-confirmed BC cases (23-85 years) and 1621 population controls, frequency matched by age, were recruited in 10 Spanish provinces...
February 2016: Cancer Epidemiology
https://www.readbyqxmd.com/read/26582399/prenatal-factors-and-infant-feeding-in-relation-to-risk-of-benign-breast-disease-in-young-women
#14
Catherine S Berkey, Bernard Rosner, Walter C Willett, Rulla M Tamimi, A Lindsay Frazier, Graham A Colditz
Benign breast disease (BBD) is a well-established risk factor for breast cancer, but little work has considered a girl's early life and her risk for BBD in adulthood. We investigated factors, from pre-conception through infant feeding practices, in relation to subsequent BBD risk in young women. The Growing Up Today Study (GUTS) includes 9032 females, born 1980-1987, who completed questionnaires annually from 1996 through 2001, then 2003, 2005, 2007, 2010, and 2013. In 1996, their mothers provided each participant's birth weight and length, gestational age, biological father's height, and infant feeding factors (e...
December 2015: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/26526858/puberty-specific-promotion-of-mammary-tumorigenesis-by-a-high-animal-fat-diet
#15
Mark D Aupperlee, Yong Zhao, Ying Siow Tan, Yirong Zhu, Ingeborg M Langohr, Erin L Kirk, Jason R Pirone, Melissa A Troester, Richard C Schwartz, Sandra Z Haslam
INTRODUCTION: Increased animal fat consumption is associated with increased premenopausal breast cancer risk in normal weight, but not overweight, women. This agrees with our previous findings in obesity-resistant BALB/c mice, in which exposure to a high saturated animal fat diet (HFD) from peripuberty through adulthood promoted mammary tumorigenesis. Epidemiologic and animal studies support the importance of puberty as a life stage when diet and environmental exposures affect adult breast cancer risk...
November 2, 2015: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/26262729/-influence-of-reproductive-factors-breastfeeding-and-obesity-on-the-risk-of-breast-cancer-in-mexican-women
#16
María Jossé Navarro-Ibarra, Graciela Caire-Juvera, María Isabel Ortega-Vélez, Adriana Verónica Bolaños-Villar, María Del Socorro Saucedo-Tamayo
Breast cancer (BC) is considered a global public health problem, and is the most frequently type diagnosed in Mexican women. Therefore, it is important to study the risk factors associated to this neoplasia in order to establish prevention strategies. The aim of this study was to evaluate the effect of hormonal contraceptives and hormone therapy (HT) use and period of use, breastfeeding practice, abdominal obesity and weight gain in adulthood, on the risk of BC in adult women from Northwest Mexico. This was a case-control study that included 162 women (81 cases and 81 controls)...
2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/26260748/genistein-reduces-the-noxious-effects-of-in-utero-bisphenol-a-exposure-on-the-rat-prostate-gland-at-weaning-and-in-adulthood
#17
COMPARATIVE STUDY
Bruna Dias Bernardo, Joyce Zalotti Brandt, Tony Fernando Grassi, Lívia Teresa R Silveira, Wellerson Rodrigo Scarano, Luis Fernando Barbisan
Bisphenol A (BPA) is one hormonally active chemical with potential deleterious effects on reproductive organs, including breast and prostate. In contrast, genistein (GEN) is the major phytoestrogen of soy that presents potential protective effects against hormone-dependent cancers, including that of the prostate. Thus, pregnant Sprague-Dawley rats were treated with BPA at 25 or 250 μg/kg/day by gavage from gestational day (GD) 10-21 with or without dietary GEN at 250 mg/kg/chow (∼5.5 mg/kg/day). Then, male offspring from different litters were euthanized on post-natal day (PND) 21 and 180...
October 2015: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/26115784/lipidomic-fatty-acid-profile-and-global-gene-expression-pattern-in-mammary-gland-of-rats-that-were-exposed-to-lard-based-high-fat-diet-during-fetal-and-lactation-periods-associated-to-breast-cancer-risk-in-adulthood
#18
Fábia de Oliveira Andrade, Sonia de Assis, Lu Jin, Camile Castilho Fontelles, Luís Fernando Barbisan, Eduardo Purgatto, Leena Hilakivi-Clarke, Thomas Prates Ong
The persistent effects of animal fat consumption during pregnancy and nursing on the programming of breast cancer risk among female offspring were studied here. We have previously found that female offspring of rat dams that consumed a lard-based high-fat (HF) diet (60% fat-derived energy) during pregnancy, or during pregnancy and lactation, were at a reduced risk of developing mammary cancer. To better understand the unexpected protective effects of early life lard exposure, we have applied lipidomics and nutrigenomics approaches to investigate the fatty acid profile and global gene expression patterns in the mammary tissue of the female offspring...
September 5, 2015: Chemico-biological Interactions
https://www.readbyqxmd.com/read/26041651/adolescent-endogenous-sex-hormones-and-breast-density-in-early-adulthood
#19
RANDOMIZED CONTROLLED TRIAL
Seungyoun Jung, Brian L Egleston, D Walt Chandler, Linda Van Horn, Nola M Hylton, Catherine C Klifa, Norman L Lasser, Erin S LeBlanc, Kenneth Paris, John A Shepherd, Linda G Snetselaar, Frank Z Stanczyk, Victor J Stevens, Joanne F Dorgan
INTRODUCTION: During adolescence the breasts undergo rapid growth and development under the influence of sex hormones. Although the hormonal etiology of breast cancer is hypothesized, it remains unknown whether adolescent sex hormones are associated with adult breast density, which is a strong risk factor for breast cancer. METHODS: Percentage of dense breast volume (%DBV) was measured in 2006 by magnetic resonance imaging in 177 women aged 25-29 years who had participated in the Dietary Intervention Study in Children from 1988 to 1997...
2015: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/25993238/can-diet-and-lifestyle-prevent-breast-cancer-what-is-the-evidence
#20
REVIEW
Michelle Harvie, Anthony Howell, D Gareth Evans
Breast cancer is the most common cancer among women in both developed and less-developed countries. Rates of breast cancer are increasing worldwide, with a particular increase in postmenopausal and estrogen receptor-positive cases. The World Cancer Research Fund (WCRF) and American Cancer Society (ACS) cancer prevention guidelines recommend maintaining a healthy weight, undertaking at least 150 minutes of moderate intensity exercise per week, limiting alcohol consumption, and eating a plant-based diet. Observational data link adherence to physical activity and alcohol guidelines throughout life to a reduced risk of developing pre- and postmenopausal breast cancer...
2015: American Society of Clinical Oncology Educational Book
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