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Breast cancer and early adulthood

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https://www.readbyqxmd.com/read/28965165/alcohol-consumption-and-mammographic-density-in-the-danish-diet-cancer-and-health-cohort
#1
Katja Kemp Jacobsen, Elsebeth Lynge, Anne Tjønneland, Ilse Vejborg, My von Euler-Chelpin, Zorana J Andersen
PURPOSE: We examined the association between alcohol consumption and mammographic density (MD) considering in detail the time of exposure and the type of alcohol. METHODS: Of 5,356 women (4,489 post-menopausal) from the Danish Diet, Cancer and Health cohort (1993-1997) who attended mammographic screening in Copenhagen (1993-2001), we used MD (mixed/dense or fatty) assessed at the first screening after cohort entry. Alcohol consumption was assessed at the time of recruitment...
September 30, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28952004/alcohol-consumption-across-the-life-course-and-mammographic-density-in-premenopausal-women
#2
Ying Liu, Rulla M Tamimi, Graham A Colditz, Kimberly A Bertrand
PURPOSE: Consumption of alcoholic beverages during adolescence and early adulthood has been consistently associated with higher breast cancer risk. The influence of alcohol consumption early in life on mammographic breast density, a marker of breast cancer risk, is inconclusive. This study examined associations of alcohol consumption across the life course with premenopausal mammographic density. METHODS: The study population included 1211 premenopausal women in the Nurses' Health Study II without cancer, who recalled their alcohol consumption at age 15 through enrollment in 1989 (baseline), and had mammograms available...
September 26, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28874690/a-single-neonatal-administration-of-bisphenol-a-induces-higher-tumour-weight-associated-to-changes-in-tumour-microenvironment-in-the-adulthood
#3
Margarita Isabel Palacios-Arreola, Karen Elizabeth Nava-Castro, Víctor Hugo Del Río-Araiza, Nashla Yazmín Pérez-Sánchez, Jorge Morales-Montor
BPA is an oestrogenic endocrine disrupting chemical compound. Exposure to BPA in as early as pregnancy leads to lifelong effects. Since endocrine and immune systems interact in a bidirectional manner, endocrine disruption may cause permanent alterations of the immune system, affecting a future anti-tumoral response. Neonate (PND 3) female syngeneic BALB/c mice were exposed to a single dose of 250 µg/kg BPA. Once sexual maturity was reached, a mammary tumour was induced injecting 4T1 cells in situ, these cells are derived from a spontaneous adenocarcinoma in a BALB/c mouse and therefore allows for an immunocompetent recipient...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28865460/state-of-the-evidence-2017-an-update-on-the-connection-between-breast-cancer-and-the-environment
#4
REVIEW
Janet M Gray, Sharima Rasanayagam, Connie Engel, Jeanne Rizzo
BACKGROUND: In this review, we examine the continually expanding and increasingly compelling data linking radiation and various chemicals in our environment to the current high incidence of breast cancer. Singly and in combination, these toxicants may have contributed significantly to the increasing rates of breast cancer observed over the past several decades. Exposures early in development from gestation through adolescence and early adulthood are particularly of concern as they re-shape the program of genetic, epigenetic and physiological processes in the developing mammary system, leading to an increased risk for developing breast cancer...
September 2, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28818247/alcohol-screening-and-brief-intervention-a-potential-role-in-cancer-prevention-for-young-adults
#5
Lela R McKnight-Eily, S Jane Henley, Patricia P Green, Erika C Odom, Daniel W Hungerford
Excessive or risky alcohol use is a preventable cause of significant morbidity and mortality in the U.S. and worldwide. Alcohol use is a common preventable cancer risk factor among young adults; it is associated with increased risk of developing at least six types of cancer. Alcohol consumed during early adulthood may pose a higher risk of female breast cancer than alcohol consumed later in life. Reducing alcohol use may help prevent cancer. Alcohol misuse screening and brief counseling or intervention (also called alcohol screening and brief intervention among other designations) is known to reduce excessive alcohol use, and the U...
September 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28800472/phthalate-and-bisphenol-a-exposure-during-in-utero-windows-of-susceptibility-in-relation-to-reproductive-hormones-and-pubertal-development-in-girls
#6
Deborah J Watkins, Brisa N Sánchez, Martha Maria Téllez-Rojo, Joyce M Lee, Adriana Mercado-García, Clara Blank-Goldenberg, Karen E Peterson, John D Meeker
BACKGROUND: Over the past several decades, the age of pubertal onset in girls has shifted downward worldwide. As early pubertal onset is associated with increased risky behavior and psychological issues during adolescence and cardiometabolic disease and cancer in adulthood, this is an important public health concern. Exposure to endocrine disrupting chemicals during critical windows of in utero development may play a role in this trend. Our objective was to investigate trimester-specific phthalate and BPA exposure in relation to pubertal development among girls in the Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT) birth cohort...
November 2017: Environmental Research
https://www.readbyqxmd.com/read/28776604/the-role-of-diet-physical-activity-body-fatness-and-breastfeeding-in-breast-cancer-in-young-women-epidemiological-evidence
#7
I Isabelle Romieu, A Amadou, V Chajes
The incidence of breast cancer (BC) is rising worldwide, with an increase in aggressive neoplasias in young women. Traditionally, BC in young women has been thought to be etiologically driven, primarily by genetic/hereditary factors. However, these factors explain only a small proportion of BCs, pointing to a role of the environment. Suspected factors responsible for this increase include lifestyle changes, notably alcohol consumption, diet with high intake of refined carbohydrates and saturated fat and low intake of polyunsaturated fatty acids (PUFA), fiber and vitamins (such as folate, vitamin D, and carotenoids), low physical activity, and body fatness, all of which may act from childhood and adolescent years through adulthood...
July 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28702890/adiposity-during-early-adulthood-changes-in-adiposity-during-adulthood-attained-adiposity-and-mammographic-density-among-premenopausal-women
#8
Aliya Alimujiang, Catherine Appleton, Graham A Colditz, Adetunji T Toriola
PURPOSE: We investigated the associations of adolescent adiposity, changes in adiposity during adulthood, and attained adiposity with volumetric mammographic density measures. METHODS: We recruited 383 premenopausal women who had a routine screening mammogram at the Breast Health Center, Washington University in St. Louis, MO from December 2015 to October 2016. Trained research personnel assessed current adiposity measures. Weight at ages 18 and 30 were self-reported...
July 12, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28661075/mri-reveals-increased-tumorigenesis-following-high-fat-feeding-in-a-mouse-model-of-triple-negative-breast-cancer
#9
Devkumar Mustafi, Sully Fernandez, Erica Markiewicz, Xiaobing Fan, Marta Zamora, Jeffrey Mueller, Matthew J Brady, Suzanne D Conzen, Gregory S Karczmar
High animal fat consumption is associated with an increase in triple-negative breast cancer (TNBC) risk. Based on previous MRI studies demonstrating the feasibility of detecting very early non-palpable mammary cancers in simian virus 40 large T antigen (SV40TAg) mice, we examined the effect of dietary fat fed from weaning to young adulthood in this model of TNBC. Virgin female C3(1)SV40TAg mice (n = 16) were weaned at 3-4 weeks of age and then fed either a low fat diet (LFD) (n = 8, 3.7 kcal/g; 17.2% kcal from vegetable oil) or a high animal fat diet (HAFD) (n = 8, 5...
June 29, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28632866/risks-of-breast-ovarian-and-contralateral-breast-cancer-for-brca1-and-brca2-mutation-carriers
#10
Karoline B Kuchenbaecker, John L Hopper, Daniel R Barnes, Kelly-Anne Phillips, Thea M Mooij, Marie-José Roos-Blom, Sarah Jervis, Flora E van Leeuwen, Roger L Milne, Nadine Andrieu, David E Goldgar, Mary Beth Terry, Matti A Rookus, Douglas F Easton, Antonis C Antoniou, BRCA1 and BRCA2 Cohort Consortium, Lesley McGuffog, D Gareth Evans, Daniel Barrowdale, Debra Frost, Julian Adlard, Kai-Ren Ong, Louise Izatt, Marc Tischkowitz, Ros Eeles, Rosemarie Davidson, Shirley Hodgson, Steve Ellis, Catherine Nogues, Christine Lasset, Dominique Stoppa-Lyonnet, Jean-Pierre Fricker, Laurence Faivre, Pascaline Berthet, Maartje J Hooning, Lizet E van der Kolk, Carolien M Kets, Muriel A Adank, Esther M John, Wendy K Chung, Irene L Andrulis, Melissa Southey, Mary B Daly, Saundra S Buys, Ana Osorio, Christoph Engel, Karin Kast, Rita K Schmutzler, Trinidad Caldes, Anna Jakubowska, Jacques Simard, Michael L Friedlander, Sue-Anne McLachlan, Eva Machackova, Lenka Foretova, Yen Y Tan, Christian F Singer, Edith Olah, Anne-Marie Gerdes, Brita Arver, Håkan Olsson
Importance: The clinical management of BRCA1 and BRCA2 mutation carriers requires accurate, prospective cancer risk estimates. Objectives: To estimate age-specific risks of breast, ovarian, and contralateral breast cancer for mutation carriers and to evaluate risk modification by family cancer history and mutation location. Design, Setting, and Participants: Prospective cohort study of 6036 BRCA1 and 3820 BRCA2 female carriers (5046 unaffected and 4810 with breast or ovarian cancer or both at baseline) recruited in 1997-2011 through the International BRCA1/2 Carrier Cohort Study, the Breast Cancer Family Registry and the Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, with ascertainment through family clinics (94%) and population-based studies (6%)...
June 20, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28600777/psychoneuroimmunology-developments-in-stress-research
#11
REVIEW
Rainer H Straub, Maurizio Cutolo
Links between the central nervous stress system and peripheral immune cells in lymphoid organs have been detailed through 50 years of intensive research. The brain can interfere with the immune system, where chronic psychological stress inhibits many functions of the immune system. On the other hand, chronic peripheral inflammation-whether mild (during aging and psychological stress) or severe (chronic inflammatory diseases)-clearly interferes with brain function, leading to disease sequelae like fatigue but also to overt psychiatric illness...
June 9, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28551081/exposure-to-stress-across-the-life-course-and-its-association-with-anxiety-and-depressive-symptoms-results-from-the-australian-women-s-wellness-after-cancer-program-wwacp
#12
Charrlotte Seib, Alexandra McCarthy, Amanda McGuire, Janine Porter-Steele, Sarah Balaam, Robert S Ware, Debra Anderson
OBJECTIVES: Earlier life stressors can increase the risk of persistent anxiety and depressive symptoms in women after cancer, though our understanding of the underlying mechanisms is limited. In this study, we tested alternative life course models to determine which best described associations between exposure to stressors in childhood, adolescence, and adulthood, and self-reported health in women previously treated for breast, gynaecological, and blood cancer. STUDY DESIGN: Data were drawn from 351 Australian women within 2 years of completing active cancer treatment who were participating in the Women's Wellness After Cancer Program (WWACP) randomised controlled trial...
May 19, 2017: Maturitas
https://www.readbyqxmd.com/read/28500399/childhood-and-teenage-physical-activity-and-breast-cancer-risk
#13
Nicole M Niehoff, Alexandra J White, Dale P Sandler
PURPOSE: Adult physical activity is associated with reduced breast cancer risk, but few studies have evaluated activity before adulthood. Early life may be an important period because of rapid breast development and hormonal changes. This study contributes new information by examining childhood (ages 5-12) and teenage (ages 13-19) activity separately and overall. METHODS: The Sister Study is a cohort of 50,884 women aged 35-74. Women reported age 5-19 sports/exercise activities and age 10 and 16 unstructured activities...
August 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28399571/testing-for-gene-environment-interactions-using-a-prospective-family-cohort-design-body-mass-index-in-early-and-later-adulthood-and-risk-of-breast-cancer
#14
Gillian S Dite, Robert J MacInnis, Adrian Bickerstaffe, James G Dowty, Roger L Milne, Antonis C Antoniou, Prue Weideman, Carmel Apicella, Graham G Giles, Melissa C Southey, Mark A Jenkins, Kelly-Anne Phillips, Aung Ko Win, Mary Beth Terry, John L Hopper
The ability to classify people according to their underlying genetic susceptibility to a disease is increasing with new knowledge, better family data, and more sophisticated risk prediction models, allowing for more effective prevention and screening. To do so, however, we need to know whether risk associations are the same for people with different genetic susceptibilities. To illustrate one way to estimate such gene-environment interactions, we used prospective data from 3 Australian family cancer cohort studies, 2 enriched for familial risk of breast cancer...
March 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28360138/mathematical-modeling-links-pregnancy-associated-changes-and-breast-cancer-risk
#15
Daniel Temko, Yu-Kang Cheng, Kornelia Polyak, Franziska Michor
Recent debate has concentrated on the contribution of bad luck to cancer development. The tight correlation between the number of tissue-specific stem cell divisions and cancer risk of the same tissue suggests that bad luck has an important role to play in tumor development, but the full extent of this contribution remains an open question. Improved understanding of the interplay between extrinsic and intrinsic factors at the molecular level is one promising route to identifying the limits on extrinsic control of tumor initiation, which is highly relevant to cancer prevention...
June 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28249935/an-adolescent-and-early-adulthood-dietary-pattern-associated-with-inflammation-and-the-incidence-of-breast-cancer
#16
Holly R Harris, Walter C Willett, Rita L Vaidya, Karin B Michels
Adolescence is a highly susceptible period for mammary carcinogenesis, but few prospective studies have examined the role of adolescent diet in breast cancer risk. Reduced rank regression has previously been used to identify a dietary pattern associated with markers of inflammation (C-reactive protein, IL6, and TNFα receptor 2). We investigated whether an adolescent and early adulthood inflammatory dietary pattern was associated with breast cancer among 45,204 women in the Nurses' Health Study II using reduced rank regression...
March 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28133728/weight-and-weight-changes-in-early-adulthood-and-later-breast-cancer-risk
#17
Bernard Rosner, A Heather Eliassen, Adetunji T Toriola, Wendy Y Chen, Susan E Hankinson, Walter C Willett, Catherine S Berkey, Graham A Colditz
Obesity is a well-established cause of postmenopausal breast cancer. However, early life adiposity is inversely associated with breast cancer incidence. To understand these conflicting relations, we use validated measures to assess adiposity in childhood and late adolescence, as well as weight change, in relation to total invasive breast cancer incidence and receptor subtypes. We conducted a prospective observational study among 74,177 women from the Nurses' Health Study from 1980-2012, with updated risk factors every 2 years during which 4,965 incident invasive breast cancers occurred...
May 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28069684/weight-fluctuation-and-cancer-risk-in-postmenopausal-women-the-women-s-health-initiative
#18
Laura M Welti, Daniel P Beavers, Bette J Caan, Haleh Sangi-Haghpeykar, Mara Z Vitolins, Kristen M Beavers
Background: Weight cycling, defined by an intentional weight loss and subsequent regain, commonly occurs in overweight and obese women and is associated with some negative health outcomes. We examined the role of various weight-change patterns during early to mid-adulthood and associated risk of highly prevalent, obesity-related cancers (breast, endometrial, and colorectal) in postmenopausal women.Methods: A total of 80,943 postmenopausal women (age, 63.4 ± 7.4 years) in the Women's Health Initiative Observational Study were categorized by self-reported weight change (weight stable; weight gain; lost weight; weight cycled [1-3, 4-6, 7-10, >10 times]) during early to mid-adulthood (18-50 years)...
May 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28068940/early-life-socioeconomic-environment-and-mammographic-breast-density
#19
Parisa Tehranifar, Barbara A Cohn, Julie D Flom, Angeline Protacio, Piera Cirillo, L H Lumey, Karin B Michels, Mary Beth Terry
BACKGROUND: Early life social environment may influence breast cancer through shaping risk factors operating in early life, adolescence and adulthood, or may be associated with breast cancer risk independent of known risk factors. We investigated the associations between early life socioeconomic status (SES) and mammographic density, a strong risk factor for breast cancer, and the extent to which these associations were independent of risk factors across the lifecourse. METHODS: We used data from an adult follow-up study of two U...
January 10, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28062981/body-size-from-birth-through-adolescence-in-relation-to-risk-of-benign-breast-disease-in-young-women
#20
Catherine S Berkey, Bernard Rosner, Rulla M Tamimi, Walter C Willett, Martha Hickey, Adetunji Toriola, A Lindsay Frazier, Graham A Colditz
PURPOSE: Body size, from birth throughout adulthood, is associated with breast cancer risk, but few studies have investigated early-life body size and benign breast disease (BBD), a well-established breast cancer risk factor. We consider whether prenatal factors and size at birth, 10, 18 year, and intervening growth, are related to BBD risk. METHODS: The Growing Up Today Study includes 9032 females who completed questionnaires annually from 1996 to 2001, then 2003, 2005, 2007, 2010, and 2013...
February 2017: Breast Cancer Research and Treatment
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