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https://www.readbyqxmd.com/read/28845050/preservation-of-fertility-or-ovarian-function-in-patients-with-breast-cancer-or-gynecologic-and-internal-malignancies
#1
Angrit Stachs, Steffi Hartmann, Bernd Gerber
Because of the efficacy of systemic therapies, neoplasias which occur in pediatric and adolescent patients and in young adults have high cure rates. This means that fulfilling their wish to have children has become a more pressing concern, particularly among young women with malignant tumors. Premature ovarian failure is also a not insignificant problem as it has a lasting detrimental effect on quality of life. Every oncology patient who may potentially wish to have children should be informed about their options for preserving fertility prior to starting treatment...
August 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28800472/phthalate-and-bisphenol-a-exposure-during-in-utero-windows-of-susceptibility-in-relation-to-reproductive-hormones-and-pubertal-development-in-girls
#2
Deborah J Watkins, Brisa N Sánchez, Martha Maria Téllez-Rojo, Joyce M Lee, Adriana Mercado-García, Clara Blank-Goldenberg, Karen E Peterson, John D Meeker
BACKGROUND: Over the past several decades, the age of pubertal onset in girls has shifted downward worldwide. As early pubertal onset is associated with increased risky behavior and psychological issues during adolescence and cardiometabolic disease and cancer in adulthood, this is an important public health concern. Exposure to endocrine disrupting chemicals during critical windows of in utero development may play a role in this trend. Our objective was to investigate trimester-specific phthalate and BPA exposure in relation to pubertal development among girls in the Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT) birth cohort...
August 8, 2017: Environmental Research
https://www.readbyqxmd.com/read/28765858/history-development-and-future-of-cancer-screening-in-australia
#3
Ian N Olver, David Roder
INTRODUCTION: The aim of screening an asymptomatic population for cancer is to achieve better health outcomes, particularly a population survival benefit. Australia has three population screening programs: the National Cervical Screening Program (NCSP), BreastScreen Australia and the National Bowel Cancer Screening Program (NBCSP). METHODS: We reviewed the history and development of the three programs. NCSP: Women have a Pap smear every 2 years from age 18-20, or 2 years after first becoming sexually active, until age 69...
July 26, 2017: Public Health Research & Practice
https://www.readbyqxmd.com/read/28647059/-silhouettes-at-different-age-of-life-retrospective-appreciation-of-corpulence-and-his-impact-on-prevalence-of-hypertension-at-60years
#4
F Thomas, J P Empana, M A Charles, P Boutouyrie, X Jouven, B Pannier, N Danchin
PURPOSE OF THE STUDY: In epidemiological studies, recall of weight and height are not readily available at different ages of life. In order to improve the knowledge of the weight history, Sörensen et al. in 1983, developed a tool from silhouettes allowing an individual to evaluate his corpulence at different ages of life. Validity studies showed that measured weight and size were correlated to 80% in the reported silhouette. Studies have also shown that silhouettes are a good way to trace the weight history in an individual's life...
June 21, 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/28622765/unusual-primary-breast-cancer-malignant-peripheral-nerve-sheath-tumor-a-case-report-and-review-of-the-literature
#5
Md Shuayb, Rabeya Begum
BACKGROUND: Sarcomas are a rare type of breast malignancies and malignant peripheral nerve sheath tumors of the breast are even rarer. There are no specific clinical and radiological features for the diagnosis of this tumor and histological features are also reported to be nonspecific. Therefore, immunohistochemistry is required for its diagnosis. A definitive treatment protocol is unavailable because of its rarity. CASE PRESENTATION: We report a case of a sporadic form of breast malignant peripheral nerve sheath tumor found in a 16-year-old Asian Bangladeshi girl...
June 17, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28602452/disease-severity-presentation-and-clinical-outcomes-among-adolescents-with-malignant-breast-neoplasms-a-20-year-population-based-outcomes-study-from-the-seer-database-1973-2009
#6
Vijayashree Murthy, Shonali Pawar, Ronald S Chamberlain
INTRODUCTION: Primary breast cancer in adolescents is extremely rare and thus is not widely studied. This study aimed to evaluate trends, characteristics, and outcomes among a cohort of adolescents with breast cancer. PATIENTS AND METHODS: A total of 657,712 female patients with breast cancer from Surveillance Epidemiology and End Results (SEER) database (1973-2009) were analyzed, and 91 adolescents were identified. Three age groups (under 20 years, 20-50 years or premenopausal, and > 50 years or postmenopausal) were compared for tumor size, stage, receptor status, and outcomes...
May 8, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28595647/pubertal-development-in-girls-by-breast-cancer-family-history-the-legacy-girls-cohort
#7
Mary Beth Terry, Theresa H M Keegan, Lauren C Houghton, Mandy Goldberg, Irene L Andrulis, Mary B Daly, Saundra S Buys, Ying Wei, Alice S Whittemore, Angeline Protacio, Angela R Bradbury, Wendy K Chung, Julia A Knight, Esther M John
BACKGROUND: Pubertal milestones, such as onset of breast development and menstruation, play an important role in breast cancer etiology. It is unclear if these milestones are different in girls with a first- or second-degree breast cancer family history (BCFH). METHODS: In the LEGACY Girls Study (n = 1040), we examined whether three mother/guardian-reported pubertal milestones (having reached Tanner Stage 2 or higher (T2+) for breast and pubic hair development, and having started menstruation) differed by BCFH...
June 8, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28525533/phenol-concentrations-during-childhood-and-subsequent-measures-of-adiposity-among-young-girls
#8
Andrea L Deierlein, Mary S Wolff, Ashley Pajak, Susan M Pinney, Gayle C Windham, Maida P Galvez, Michael Rybak, Antonia M Calafat, Lawrence H Kushi, Frank M Biro, Susan L Teitelbaum
Phenolic compounds represent a class of environmental chemicals with potentially endocrine-disrupting capabilities. We investigated longitudinal associations between childhood exposure to phenols, from both manmade and natural sources, and subsequent measures of adiposity among girls enrolled in the Breast Cancer and the Environment Research Program between 2004 and 2007. Baseline (ages 6-8 years) urinary concentrations were obtained for creatinine and phenol metabolites: enterolactone, genistein, daidzein, benzophenone-3, bisphenol A, the sum of parabens (methyl, ethyl, and propyl parabens), 2,5-dichlorophenol, and triclosan...
September 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28362651/breast-cancer-education-for-schoolgirls-an-exploratory-study
#9
Nicola Brown, Jenny Smith, Amanda Brasher, Atefeh Omrani, Joanna Wakefield-Scurr
Adolescent girls are an important target group for breast cancer education and promoting breast awareness. However, research has not established schoolgirls' perceived importance of breast cancer education or explored factors that may impact engagement. This study aimed to identify schoolgirls' concerns about breast cancer, desire to know more and perceived importance of breast cancer education, and explored associations with demographic factors. Of 2089 schoolgirls (11-18 years) surveyed, 1958 completed all relevant breast cancer questions and demographic factors (ethnicity, school type, breast size, physical activity level and age)...
March 30, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28334947/protocadherin-19-pcdh19-interacts-with-paraspeckle-protein-nono-to-co-regulate-gene-expression-with-estrogen-receptor-alpha-er%C3%AE
#10
Duyen H Pham, Chuan C Tan, Claire C Homan, Kristy L Kolc, Mark A Corbett, Dale McAninch, Archa H Fox, Paul Q Thomas, Raman Kumar, Jozef Gecz
De novo and inherited mutations of X-chromosome cell adhesion molecule protocadherin 19 (PCDH19) cause frequent, highly variable epilepsy, autism, cognitive decline and behavioural problems syndrome. Intriguingly, hemizygous null males are not affected while heterozygous females are, contradicting established X-chromosome inheritance. The disease mechanism is not known. Cellular mosaicism is the likely driver. We have identified p54nrb/NONO, a multifunctional nuclear paraspeckle protein with known roles in nuclear hormone receptor gene regulation, as a PCDH19 protein interacting partner...
June 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28216130/amphiregulin-as-a-novel-serum-marker-of-puberty-in-girls
#11
Frank M Biro, Susan M Pinney, Richard C Schwartz, Bin Huang, Ashley M Cattran, Sandra Z Haslam
STUDY OBJECTIVE: Amphiregulin is a member of the epidermal growth factor family. In breast tissue, amphiregulin is a mediator of estrogen and progesterone signaling. The objectives were to examine the relationship of amphiregulin levels during peripuberty with estrogen levels. DESIGN, SETTING, PARTICIPANTS, INTERVENTIONS, AND MAIN OUTCOME MEASURES: The participants in this analysis were a subset from a longitudinal study of pubertal maturation, the Breast Cancer and the Environment Research Program...
February 16, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28170386/peripubertal-dietary-flavonol-and-lignan-intake-and-age-at-menarche-in-a-longitudinal-cohort-of-girls
#12
Nancy A Mervish, Susan L Teitelbaum, Ashley Pajak, Gayle C Windham, Susan M Pinney, Lawrence H Kushi, Frank M Biro, Mary S Wolff
BackgroundDietary phytoestrogens may alter hormonal activity in childhood. Flavonols and lignans are the most prevalent phytoestrogens in the Western diet. We examined whether higher intake of flavonols and lignans was associated with later age at menarche in a prospective study of young girls.MethodsIn all, 1,044 girls aged 6-8 years (mean 7.3 years) with two to four 24-h dietary recalls during their baseline year were followed up for 11 years until the attainment of menarche in the Breast Cancer and Environment Research Project (BCERP)...
August 2017: Pediatric Research
https://www.readbyqxmd.com/read/28166807/non-invasive-optical-spectroscopic-monitoring-of-breast-development-during-puberty
#13
Lothar Lilge, Mary Beth Terry, Jane Walter, Dushanthi Pinnaduwage, Gord Glendon, Danielle Hanna, Mai-Liis Tammemagi, Angela Bradbury, Saundra Buys, Mary Daly, Esther M John, Julia A Knight, Irene L Andrulis
BACKGROUND: Tanner staging (TS), a five-stage classification indicating no breast tissue (TS1) to full breast development (TS5), is used both in health research and clinical care to assess the onset of breast development (TS2) and duration in each stage. Currently, TS is measured both visually and through palpation but non-invasive methods will improve comparisons across settings. METHODS: We used optical spectroscopy (OS) measures from 102 girls at the Ontario site of the LEGACY girls study (average age 12 years, range 10...
February 6, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28062981/body-size-from-birth-through-adolescence-in-relation-to-risk-of-benign-breast-disease-in-young-women
#14
Catherine S Berkey, Bernard Rosner, Rulla M Tamimi, Walter C Willett, Martha Hickey, Adetunji Toriola, A Lindsay Frazier, Graham A Colditz
PURPOSE: Body size, from birth throughout adulthood, is associated with breast cancer risk, but few studies have investigated early-life body size and benign breast disease (BBD), a well-established breast cancer risk factor. We consider whether prenatal factors and size at birth, 10, 18 year, and intervening growth, are related to BBD risk. METHODS: The Growing Up Today Study includes 9032 females who completed questionnaires annually from 1996 to 2001, then 2003, 2005, 2007, 2010, and 2013...
February 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28024679/gender-norms-as-health-harms-reclaiming-a-life-course-perspective-on-sexual-and-reproductive-health-and-rights
#15
Cailin Crockett, Bergen Cooper
Despite their demographic significance and the lifetime impact of gender disparities on their health and rights, women considered older than reproductive age are excluded from most investments in global public health. While development policies linking human rights with access to sexual and reproductive healthcare have yielded progress towards improving the status of women and girls, older women have not benefited from these initiatives. Yet as women grow older, they experience a range of health conditions rooted in their reproductive biology - from ageing with fistula, to cervical and breast cancers...
November 2016: Reproductive Health Matters
https://www.readbyqxmd.com/read/27851993/associations-of-urinary-phthalate-and-phenol-biomarkers-with-menarche-in-a-multiethnic-cohort-of-young-girls
#16
Mary S Wolff, Ashley Pajak, Susan M Pinney, Gayle C Windham, Maida Galvez, Michael Rybak, Manori J Silva, Xiaoyun Ye, Antonia M Calafat, Lawrence H Kushi, Frank M Biro, Susan L Teitelbaum
To study potential environmental influences on puberty in girls, we investigated urinary biomarkers in relation to age at menarche. Phenols and phthalates were measured at baseline (6-8 years of age). Menarche was ascertained over 11 years for 1051 girls with menarche and biomarkers. Hazards ratios were estimated from Cox models adjusted for race/ethnicity and caregiver education (aHR, 95% confidence intervals [CI] for 5th vs 1st quintile urinary biomarker concentrations). 2,5-Dichlorophenol was associated with earlier menarche (aHR 1...
January 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/27814963/interventions-to-close-the-divide-for-women-with-breast-and-cervical-cancer-between-low-income-and-middle-income-countries-and-high-income-countries
#17
REVIEW
Lynette Denny, Silvia de Sanjose, Miriam Mutebi, Benjamin O Anderson, Jane Kim, Jose Jeronimo, Rolando Herrero, Karen Yeates, Ophira Ginsburg, Rengaswamy Sankaranarayanan
Breast and cervical cancers are the commonest cancers diagnosed in women living in low-income and middle-income countries (LMICs), where opportunities for prevention, early detection, or both, are few. Yet several cost-effective interventions could be used to reduce the burden of these two cancers in resource-limited environments. Population- wide vaccination against human papillomavirus (HPV) linked to cervical screening, at least once, for adult women has the potential to reduce the incidence of cervical cancer substantially...
November 1, 2016: Lancet
https://www.readbyqxmd.com/read/27780981/longitudinal-observation-of-serum-anti-m%C3%A3-llerian-hormone-in-three-girls-after-cancer-treatment
#18
Yoko Miyoshi, Kie Yasuda, Makiko Tachibana, Hisao Yoshida, Emiko Miyashita, Takako Miyamura, Yoshiko Hashii, Kae Hashimoto, Tadashi Kimura, Keiichi Ozono
Gonadal dysfunction and infertility are major endocrinological late effects among childhood cancer survivors. Chemotherapy and radiation have gonadotoxic effects and diminish the ovarian reserve. The serum concentration of anti-Müllerian hormone (AMH) is a useful marker of ovarian reserve in survivors. We conducted a longitudinal study to investigate the variations of AMH in evaluating the acute and chronic effects of cancer therapy on the ovary. Three young female patients with different hematological diseases were registered, and their medical records were reviewed...
October 2016: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/27721839/effects-of-early-menarche-on-physical-and-psychosocial-health-problems-in-adolescent-girls-and-adult-women
#19
REVIEW
Jae-Ho Yoo
The menarcheal age of Korean women has been rapidly decreasing for the last 50 years, and the average menarcheal age of women born in the 1990s is approaching 12.6 years. In addition, interest in early puberty has been increasing recently owing to the rapid increase in precocious puberty. Generally, out of concern for short stature and early menarche, idiopathic central precocious puberty in female adolescents is treated with gonadotropin-releasing hormone analogs. Studies to date have described the association between early menarche and psychosocial problems such as delinquency and risky sexual behavior, as well as physical health problems such as obesity, diabetes, cardiovascular diseases, and breast cancer throughout the lifespan of women...
September 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/27599475/correlation-of-body-mass-index-levels-with-menarche-in-adolescent-girls-in-shaanxi-china-a-cross-sectional-study
#20
Zhenjie Wang, Shaonong Dang, Yuan Xing, Qiang Li, Hong Yan
BACKGROUND: Menarche is a milestone for adolescent girls. The timing of menarche is influenced by genetics, social status and nutritional status (e.g., height, weight and body mass index [BMI]) and impacts future health (e.g., obesity and breast cancer). There have been many studies on trends in age at menarche among adolescent girls in China, but few have investigated associations between growth status and the timing of menarche. This study examined the association between age at menarche and growth status among adolescent girls in Western China...
September 6, 2016: BMC Women's Health
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