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Breast cancer and girl

Jae-Ho Yoo
The menarcheal age of Korean women has been rapidly decreasing for the last 50 years, and the average menarcheal age of women born in the 1990s is approaching 12.6 years. In addition, interest in early puberty has been increasing recently owing to the rapid increase in precocious puberty. Generally, out of concern for short stature and early menarche, idiopathic central precocious puberty in female adolescents is treated with gonadotropin-releasing hormone analogs. Studies to date have described the association between early menarche and psychosocial problems such as delinquency and risky sexual behavior, as well as physical health problems such as obesity, diabetes, cardiovascular diseases, and breast cancer throughout the lifespan of women...
September 2016: Korean Journal of Pediatrics
Zhenjie Wang, Shaonong Dang, Yuan Xing, Qiang Li, Hong Yan
BACKGROUND: Menarche is a milestone for adolescent girls. The timing of menarche is influenced by genetics, social status and nutritional status (e.g., height, weight and body mass index [BMI]) and impacts future health (e.g., obesity and breast cancer). There have been many studies on trends in age at menarche among adolescent girls in China, but few have investigated associations between growth status and the timing of menarche. This study examined the association between age at menarche and growth status among adolescent girls in Western China...
2016: BMC Women's Health
Angela R Bradbury, Linda Patrick-Miller, Lisa A Schwartz, Brian L Egleston, Dare Henry-Moss, Susan M Domchek, Mary B Daly, Lisa Tuchman, Cynthia Moore, Paula K Rauch, Rebecca Shorter, Kelsey Karpink, Colleen Burke Sands
PURPOSE: To evaluate the impact of breast cancer family history and maternal BRCA1/2 mutation on the psychosocial adjustment and perceived risk in girls age 11 to 19 years old. MATERIALS AND METHODS: Girls age 11 to 19 years old with one or more relatives with breast cancer or a familial BRCA1/2 mutation (breast cancer family history [BCFH] positive, n = 208; n = 69 with BRCA1/2-positive mother), peers (BCFH negative, n = 112), and their mothers completed assessments of psychosocial adjustment, breast cancer-specific distress, and perceived risk of breast cancer...
October 1, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Laura A McGuinn, Robert W Voss, Cecile A Laurent, Louise C Greenspan, Lawrence H Kushi, Gayle C Windham
BACKGROUND: Traffic-related air pollution (TRAP) has been linked with several adverse health outcomes, including preterm birth and low birth weight, which are both related to onset of puberty. No studies to date have investigated the association between TRAP and altered pubertal timing. OBJECTIVE: Determine the association between residential proximity to traffic, as a marker of long-term TRAP exposure, and age at pubertal onset in a longitudinal study of girls...
September 2016: Environment International
Inge van der Velpen, Pamela Schendelaar, Evelyn van Pinxteren-Nagler, Chantal M Mouës-Vink
A 15-year-old girl presented to the pediatrician with complaints of excessive fat distribution on the right side and breast asymmetry. At age 2, she had undergone a left-sided nephrectomy because of a stage III Wilms tumor using a transverse cut supraumbilical approach, followed by systemic chemotherapy and local radiotherapy. In the case of trunk asymmetry, it is questionable which side is deviant. The asymmetry may be an expression of isolated hemihyperthrophy, syndromal hemihypertrophy related to the Wilms tumor, or an expression of left-sided hemiatrophy as a late consequence of radiotherapy, chemotherapy, or surgery...
April 2016: Plastic and Reconstructive Surgery. Global Open
Adrian Surd, Aurel Mironescu, Horatiu Gocan
BACKGROUND: Supernumerary breast or polymastia is a well documented anomaly of the breast, and commonly presents along the embryonic milk line extending between the axilla and groin. However, cases of polymastia have been recorded in the face, vulva, and perineum. The clinical significance of these anomalies include their susceptibility to inflammatory and malignant changes, and their association with other congenital anomalies of the urinary and cardiovascular systems. CASE: In this article we report a case of fibroadenoma that developed in the supernumerary breast of the right axilla in a 17-year-old girl...
October 2016: Journal of Pediatric and Adolescent Gynecology
Chang-Jun Zhang, Ying Zhang, Guang-Zhu Hu, Honglu Diao
OBJECTIVE: To present a case of twin pregnancy obtained by in vitro fertilization and embryo transfer (IVF-ET) with variable dose letrozole-FSH protocol of lower peak estradiol level, after treatment of carcinoma of the breast. MATERIALS AND METHODS: A 34-year-old patient diagnosed with mucinous breast carcinoma undergoing assisted fertilization treatment after breast cancer operation and treatment including controlled ovarian stimulation (COS), oocyte retrieval, IVF, and embryo culture and transfer...
2016: European Journal of Gynaecological Oncology
Daniela Larizza, Michela Albanesi, Annalisa De Silvestri, Giulia Accordino, Valeria Brazzelli, Gabriella Carnevale Maffè, Valeria Calcaterra
AIM OF THE STUDY: Turmer syndrome (TS) patients show increased morbidity due to metabolic, autoimmune and cardiovascular disorders. A risk of neoplasia is also reported. Here, we review the prevalence of neoplasia in a cohort of Turner patients. METHODS: We retrospectively evaluated 87 TS women. Follow-up included periodic ultrasound of the neck, abdominal and pelvic organs, dermatologic evaluation and fecal occult blood test. Karyotype was 45,X in 46 patients...
May 2016: European Journal of Medical Genetics
Andrea L Deierlein, Mary S Wolff, Ashley Pajak, Susan M Pinney, Gayle C Windham, Maida P Galvez, Manori J Silva, Antonia M Calafat, Lawrence H Kushi, Frank M Biro, Susan L Teitelbaum
BACKGROUND: Phthalates are environmental chemicals that may play a role in the development of obesity. Few studies have investigated longitudinal associations between postnatal phthalate exposures and subsequent anthropometric measurements in children. METHODS: We collected data as part of The Breast Cancer and Environment Research Program at three US sites. A total of 1,239 girls, aged 6-8 years, were enrolled in 2004-2007. We categorized baseline phthalate exposures, assessed from creatinine-corrected urinary concentrations of low-molecular weight phthalate metabolites, as low, <78; medium, 78 to <194; and high, ≥194 μg/g creatinine and of high-molecular weight phthalates as low, <111; medium, 111-278; and high, ≥278 μg/g creatinine...
July 2016: Epidemiology
Erica C Jansen, Constanza Marín, Mercedes Mora-Plazas, Eduardo Villamor
BACKGROUND: Early age at menarche is associated with increased breast cancer risk. Red meat consumption in adolescence predicts breast cancer risk, but it is unknown whether it is also related to earlier menarche. OBJECTIVE: We studied the association between intake of red meat at ages 5-12 y and age at menarche in a prospective study. METHODS: We assessed usual diets with a food-frequency questionnaire in a group of 456 girls aged 8.4 ± 1...
March 9, 2016: Journal of Nutrition
Alberto Revelli, Francesca Salvagno, Luisa Delle Piane, Simona Casano, Francesca Evangelista, Giulia Pittatore, Alessandra Razzano, Gian L Marchino, Gianluca Gennarelli, Chiara Benedetto
Interest in fertility preservation for young women facing gonadotoxic therapies is increasing according to enhanced long-term survival rates of these patients. Women who carry a mutation in the BRCA1 or BRCA2 gene have a specifically increased lifetime risk of developing breast and tubo-ovarian cancer. Moreover, they are at high risk of undergoing premature infertility due to the medical interventions that are often performed in order to reduce cancer risk or treat an already existing malignancy. Fertility issues are relevant for healthy BRCA mutation carriers, whose family-planning decisions are often influenced by the need of prophylactic bilateral salpingo-oophorectomy at young age...
February 29, 2016: Minerva Ginecologica
Leticia Elizondo-Montemayor, Claudia Hernández-Escobar, Eduardo Lara-Torre, Bianca Nieblas, Merith Gómez-Carmona
In the last few decades, there has been an overwhelming increase in childhood and adolescent obesity worldwide. Besides the well-recognized cardiometabolic complications and other physical conditions associated with obesity, during adolescence, it causes psychological and social distress in a period of life that is already sensitive to a girl. This in turn increases their risk of low self-esteem and depression. Furthermore, obesity diminishes health-related quality of life and years of life. Overweight and obese teenagers are more likely to have gynecologic and obstetric complications, both, during adolescence and later in life...
February 22, 2016: Journal of Pediatric and Adolescent Gynecology
Gertraud Maskarinec, Yukiko Morimoto, Michelle B Laguana, Rachel Novotny, Rachael T Leon Guerrero
Although high mammographic density is one of the strongest predictors of breast cancer risk, X-ray based mammography cannot be performed before the recommended screening age, especially not in adolescents and young women. Therefore, new techniques for breast density measurement are of interest. In this pilot study in Guam and Hawaii, we evaluated a radiation-free, bioimpedance device called Electrical Breast DensitometerTM (EBD; senoSENSE Medical Systems, Inc., Ontario, Canada) for measuring breast density in 95 women aged 31-82 years and 41 girls aged 8-18 years...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Esther M John, Mary Beth Terry, Theresa H M Keegan, Angela R Bradbury, Julia A Knight, Wendy K Chung, Caren J Frost, Lothar Lilge, Linda Patrick-Miller, Lisa A Schwartz, Alice S Whittemore, Saundra S Buys, Mary B Daly, Irene L Andrulis
BACKGROUND: Although the timing of pubertal milestones has been associated with breast cancer risk, few studies of girls' development include girls at increased breast cancer risk due to their family history. METHODS: The Lessons in Epidemiology and Genetics of Adult Cancer from Youth (LEGACY) Girls Study was initiated in 2011 in the USA and Canada to assess the relation between early life exposures and intermediate markers of breast cancer risk (e.g., pubertal development, breast tissue characteristics) and to investigate psychosocial well being and health behaviors in the context of family history...
May 2016: Epidemiology
Cynthia Marie Metz
Healthy People 2020 lists Bisphenol A (BPA) as a potential endocrine disruptor for which exposure should be reduced. The Healthy People 2020 Environmental Health Objectives focus on addressing environmental factors that negatively affect individuals' health even though the health effects of some toxic substances are not yet fully understood. An American Association of Occupational Health Nurses (AAOHN) position statement outlined the role occupational health nurses play in creating healthy and productive workplaces by promoting worker health...
January 2016: Workplace Health & Safety
Virginia Lope, Esther García-Esquinas, Beatriz Pérez-Gómez, Jone M Altzibar, Esther Gracia-Lavedan, María Ederra, Antonio José Molina de la Torre, Francisco Javier LLorca, Adonina Tardón, Víctor Moreno, Juan Bayo, Dolores Salas-Trejo, Rafael Marcos-Gragera, José Pumarega, Trinidad Dierssen-Sotos, Juan Pablo Barrio Lera, M A Concepción de Miguel Medina, Ignasi Tusquets, Pilar Amiano, Elena Boldo, Manolis Kogevinas, Nuria Aragonés, Gemma Castaño-Vinyals, Marina Pollán
BACKGROUND: Accumulated exposure to hormones and growth factors during early life may influence the future risk of breast cancer (BC). This study examines the influence of childhood-related, socio-demographic and anthropometric variables on BC risk, overall and by specific pathologic subtypes. METHODS: This is a case-control study where 1539 histologically-confirmed BC cases (23-85 years) and 1621 population controls, frequency matched by age, were recruited in 10 Spanish provinces...
February 2016: Cancer Epidemiology
Catherine S Berkey, Bernard Rosner, Walter C Willett, Rulla M Tamimi, A Lindsay Frazier, Graham A Colditz
Benign breast disease (BBD) is a well-established risk factor for breast cancer, but little work has considered a girl's early life and her risk for BBD in adulthood. We investigated factors, from pre-conception through infant feeding practices, in relation to subsequent BBD risk in young women. The Growing Up Today Study (GUTS) includes 9032 females, born 1980-1987, who completed questionnaires annually from 1996 through 2001, then 2003, 2005, 2007, 2010, and 2013. In 1996, their mothers provided each participant's birth weight and length, gestational age, biological father's height, and infant feeding factors (e...
December 2015: Breast Cancer Research and Treatment
Mary S Wolff, Susan L Teitelbaum, Kathleen McGovern, Susan M Pinney, Gayle C Windham, Maida Galvez, Ashley Pajak, Michael Rybak, Antonia M Calafat, Lawrence H Kushi, Frank M Biro
Environmental exposures to many phenols are documented worldwide and exposures can be quite high (>1 μM of urine metabolites). Phenols have a range of hormonal activity, but knowledge of effects on child reproductive development is limited, coming mostly from cross-sectional studies. We undertook a prospective study of pubertal development among 1239 girls recruited at three U.S. sites when they were 6-8 years old and were followed annually for 7 years to determine age at first breast or pubic hair development...
November 2015: Environment International
Nicolas Chevalier, Françoise Paris, Sylvie Fontana, Jérôme Delotte, Laura Gaspari, Patricia Ferrari, Charles Sultan, Patrick Fénichel
BACKGROUND: McCune-Albright syndrome (MAS), due to a somatic mutation of the GNAS1 gene, begins usually in girls with peripheral precocious puberty. Ovarian autonomy may persist in adulthood with acyclic hyperestrogenemia, infertility, and a potential risk of estrogen-dependent cancer. CASE: A 22-year-old woman, with MAS, was referred for infertility with left macropolycystic ovary, hyperestrogenemia, and chronic anovulation unsuccessfully treated by controlled hyperstimulation...
December 2015: Journal of Pediatric and Adolescent Gynecology
James D M Nicopoullos, Marie Wren, Hossam Abdalla
PURPOSE: The purpose of the study was to report a livebirth from a cryopreserved embryo created from autologous oocytes collected at 47 years and 9 months that outlines the ethical difficulties of decision-making at the extreme of reproductive age. METHODS: The method used was IVF and embryo cryopreservation within an assisted conception unit prior to adjuvant cancer treatment in a nulliparous patient diagnosed with breast carcinoma (47 years and 9 months at oocyte collection)...
October 2015: Journal of Assisted Reproduction and Genetics
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