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https://www.readbyqxmd.com/read/29235933/faster-ticking-rate-of-the-epigenetic-clock-is-associated-with-faster-pubertal-development-in-girls
#1
Alexandra M Binder, Camila Corvalan, Verónica Mericq, Ana Pereira, José Luis Santos, Steve Horvath, John Shepherd, Karin B Michels
Epigenetic age is an indicator of biological aging, capturing the impact of environmental and behavioral influences across time on cellular function. Deviance between epigenetic age and chronological age (AgeAccel) is a predictor of health. Pubertal timing has similarly been associated with cancer risk and mortality rate among females. We examined the association between AgeAccel and pubertal timing and adolescent breast composition in the longitudinal Growth and Obesity Cohort Study. AgeAccel was estimated in whole blood using the Horvath method at breast Tanner 2 (B2) and 4 (B4)...
December 13, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/29139615/breast-education-for-schoolgirls-why-what-when-and-how
#2
Nicola Brown, Jenny Smith, Amanda Brasher, Debbie Risius, Anna Marczyk, Joanna Wakefield-Scurr
Schools are fundamental settings for health education and adolescent females are an important group for promoting positive breast habits. We surveyed 2089 schoolgirls (11-18 years) to provide evidence for, and guidance on, breast education for schoolgirls. 26% reported negative feelings about their breasts and 87% reported ≥ one breast concern. 72% wanted to know more about breast cancer (69% rating this extremely important). >50% wanted to know more about breast sag and breast pain. Preferred delivery format was age eleven (50%), girls only taught sessions (41%) with female teachers (43%)...
November 15, 2017: Breast Journal
https://www.readbyqxmd.com/read/28845050/preservation-of-fertility-or-ovarian-function-in-patients-with-breast-cancer-or-gynecologic-and-internal-malignancies
#3
Angrit Stachs, Steffi Hartmann, Bernd Gerber
Because of the efficacy of systemic therapies, neoplasias which occur in pediatric and adolescent patients and in young adults have high cure rates. This means that fulfilling their wish to have children has become a more pressing concern, particularly among young women with malignant tumors. Premature ovarian failure is also a not insignificant problem as it has a lasting detrimental effect on quality of life. Every oncology patient who may potentially wish to have children should be informed about their options for preserving fertility prior to starting treatment...
August 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28800472/phthalate-and-bisphenol-a-exposure-during-in-utero-windows-of-susceptibility-in-relation-to-reproductive-hormones-and-pubertal-development-in-girls
#4
Deborah J Watkins, Brisa N Sánchez, Martha Maria Téllez-Rojo, Joyce M Lee, Adriana Mercado-García, Clara Blank-Goldenberg, Karen E Peterson, John D Meeker
BACKGROUND: Over the past several decades, the age of pubertal onset in girls has shifted downward worldwide. As early pubertal onset is associated with increased risky behavior and psychological issues during adolescence and cardiometabolic disease and cancer in adulthood, this is an important public health concern. Exposure to endocrine disrupting chemicals during critical windows of in utero development may play a role in this trend. Our objective was to investigate trimester-specific phthalate and BPA exposure in relation to pubertal development among girls in the Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT) birth cohort...
November 2017: Environmental Research
https://www.readbyqxmd.com/read/28647059/-silhouettes-at-different-age-of-life-retrospective-appreciation-of-corpulence-and-his-impact-on-prevalence-of-hypertension-at-60years
#5
F Thomas, J P Empana, M A Charles, P Boutouyrie, X Jouven, B Pannier, N Danchin
PURPOSE OF THE STUDY: In epidemiological studies, recall of weight and height are not readily available at different ages of life. In order to improve the knowledge of the weight history, Sörensen et al. in 1983, developed a tool from silhouettes allowing an individual to evaluate his corpulence at different ages of life. Validity studies showed that measured weight and size were correlated to 80% in the reported silhouette. Studies have also shown that silhouettes are a good way to trace the weight history in an individual's life...
June 21, 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/28602452/disease-severity-presentation-and-clinical-outcomes-among-adolescents-with-malignant-breast-neoplasms-a-20-year-population-based-outcomes-study-from-the-seer-database-1973-2009
#6
Vijayashree Murthy, Shonali Pawar, Ronald S Chamberlain
INTRODUCTION: Primary breast cancer in adolescents is extremely rare and thus is not widely studied. This study aimed to evaluate trends, characteristics, and outcomes among a cohort of adolescents with breast cancer. PATIENTS AND METHODS: A total of 657,712 female patients with breast cancer from Surveillance Epidemiology and End Results (SEER) database (1973-2009) were analyzed, and 91 adolescents were identified. Three age groups (under 20 years, 20-50 years or premenopausal, and > 50 years or postmenopausal) were compared for tumor size, stage, receptor status, and outcomes...
May 8, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28525533/phenol-concentrations-during-childhood-and-subsequent-measures-of-adiposity-among-young-girls
#7
Andrea L Deierlein, Mary S Wolff, Ashley Pajak, Susan M Pinney, Gayle C Windham, Maida P Galvez, Michael Rybak, Antonia M Calafat, Lawrence H Kushi, Frank M Biro, Susan L Teitelbaum
Phenolic compounds represent a class of environmental chemicals with potentially endocrine-disrupting capabilities. We investigated longitudinal associations between childhood exposure to phenols, from both manmade and natural sources, and subsequent measures of adiposity among girls enrolled in the Breast Cancer and the Environment Research Program between 2004 and 2007. Baseline (ages 6-8 years) urinary concentrations were obtained for creatinine and phenol metabolites: enterolactone, genistein, daidzein, benzophenone-3, bisphenol A, the sum of parabens (methyl, ethyl, and propyl parabens), 2,5-dichlorophenol, and triclosan...
September 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28362651/breast-cancer-education-for-schoolgirls-an-exploratory-study
#8
Nicola Brown, Jenny Smith, Amanda Brasher, Atefeh Omrani, Joanna Wakefield-Scurr
Adolescent girls are an important target group for breast cancer education and promoting breast awareness. However, research has not established schoolgirls' perceived importance of breast cancer education or explored factors that may impact engagement. This study aimed to identify schoolgirls' concerns about breast cancer, desire to know more and perceived importance of breast cancer education, and explored associations with demographic factors. Of 2089 schoolgirls (11-18 years) surveyed, 1958 completed all relevant breast cancer questions and demographic factors (ethnicity, school type, breast size, physical activity level and age)...
March 30, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28062981/body-size-from-birth-through-adolescence-in-relation-to-risk-of-benign-breast-disease-in-young-women
#9
Catherine S Berkey, Bernard Rosner, Rulla M Tamimi, Walter C Willett, Martha Hickey, Adetunji Toriola, A Lindsay Frazier, Graham A Colditz
PURPOSE: Body size, from birth throughout adulthood, is associated with breast cancer risk, but few studies have investigated early-life body size and benign breast disease (BBD), a well-established breast cancer risk factor. We consider whether prenatal factors and size at birth, 10, 18 year, and intervening growth, are related to BBD risk. METHODS: The Growing Up Today Study includes 9032 females who completed questionnaires annually from 1996 to 2001, then 2003, 2005, 2007, 2010, and 2013...
February 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27721839/effects-of-early-menarche-on-physical-and-psychosocial-health-problems-in-adolescent-girls-and-adult-women
#10
REVIEW
Jae-Ho Yoo
The menarcheal age of Korean women has been rapidly decreasing for the last 50 years, and the average menarcheal age of women born in the 1990s is approaching 12.6 years. In addition, interest in early puberty has been increasing recently owing to the rapid increase in precocious puberty. Generally, out of concern for short stature and early menarche, idiopathic central precocious puberty in female adolescents is treated with gonadotropin-releasing hormone analogs. Studies to date have described the association between early menarche and psychosocial problems such as delinquency and risky sexual behavior, as well as physical health problems such as obesity, diabetes, cardiovascular diseases, and breast cancer throughout the lifespan of women...
September 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/27599475/correlation-of-body-mass-index-levels-with-menarche-in-adolescent-girls-in-shaanxi-china-a-cross-sectional-study
#11
Zhenjie Wang, Shaonong Dang, Yuan Xing, Qiang Li, Hong Yan
BACKGROUND: Menarche is a milestone for adolescent girls. The timing of menarche is influenced by genetics, social status and nutritional status (e.g., height, weight and body mass index [BMI]) and impacts future health (e.g., obesity and breast cancer). There have been many studies on trends in age at menarche among adolescent girls in China, but few have investigated associations between growth status and the timing of menarche. This study examined the association between age at menarche and growth status among adolescent girls in Western China...
September 6, 2016: BMC Women's Health
https://www.readbyqxmd.com/read/27551110/psychosocial-adjustment-and-perceived-risk-among-adolescent-girls-from-families-with-brca1-2-or-breast-cancer-history
#12
Angela R Bradbury, Linda Patrick-Miller, Lisa A Schwartz, Brian L Egleston, Dare Henry-Moss, Susan M Domchek, Mary B Daly, Lisa Tuchman, Cynthia Moore, Paula K Rauch, Rebecca Shorter, Kelsey Karpink, Colleen Burke Sands
PURPOSE: To evaluate the impact of breast cancer family history and maternal BRCA1/2 mutation on the psychosocial adjustment and perceived risk in girls age 11 to 19 years old. MATERIALS AND METHODS: Girls age 11 to 19 years old with one or more relatives with breast cancer or a familial BRCA1/2 mutation (breast cancer family history [BCFH] positive, n = 208; n = 69 with BRCA1/2-positive mother), peers (BCFH negative, n = 112), and their mothers completed assessments of psychosocial adjustment, breast cancer-specific distress, and perceived risk of breast cancer...
October 1, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27200246/a-15-year-old-girl-with-an-asymmetric-hemitruncal-fat-distribution-hemihyperthrophy-or-hemiatrophy
#13
Inge van der Velpen, Pamela Schendelaar, Evelyn van Pinxteren-Nagler, Chantal M Mouës-Vink
A 15-year-old girl presented to the pediatrician with complaints of excessive fat distribution on the right side and breast asymmetry. At age 2, she had undergone a left-sided nephrectomy because of a stage III Wilms tumor using a transverse cut supraumbilical approach, followed by systemic chemotherapy and local radiotherapy. In the case of trunk asymmetry, it is questionable which side is deviant. The asymmetry may be an expression of isolated hemihyperthrophy, syndromal hemihypertrophy related to the Wilms tumor, or an expression of left-sided hemiatrophy as a late consequence of radiotherapy, chemotherapy, or surgery...
April 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/26962195/higher-childhood-red-meat-intake-frequency-is-associated-with-earlier-age-at-menarche
#14
Erica C Jansen, Constanza Marín, Mercedes Mora-Plazas, Eduardo Villamor
BACKGROUND: Early age at menarche is associated with increased breast cancer risk. Red meat consumption in adolescence predicts breast cancer risk, but it is unknown whether it is also related to earlier menarche. OBJECTIVE: We studied the association between intake of red meat at ages 5-12 y and age at menarche in a prospective study. METHODS: We assessed usual diets with a food-frequency questionnaire in a group of 456 girls aged 8.4 ± 1...
March 9, 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/26915924/gynecologic-and-obstetric-consequences-of-obesity-in-adolescent-girls
#15
REVIEW
Leticia Elizondo-Montemayor, Claudia Hernández-Escobar, Eduardo Lara-Torre, Bianca Nieblas, Merith Gómez-Carmona
In the past few decades, there has been an overwhelming increase in childhood and adolescent obesity worldwide. Besides the well recognized cardiometabolic complications and other physical conditions associated with obesity, during adolescence, it causes psychological and social distress in a period of life that is already sensitive for a girl. This in turn increases their risk of low self-esteem and depression. Furthermore, obesity diminishes health-related quality of life and years of life. Overweight and obese teenagers are more likely to have gynecologic and obstetric complications, during adolescence and also later in life...
April 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/26838256/bioimpedence-to-assess-breast-density-as-a-risk-factor-for-breast-cancer-in-adult-women-and-adolescent-girls
#16
Gertraud Maskarinec, Yukiko Morimoto, Michelle B Laguana, Rachel Novotny, Rachael T Leon Guerrero
Although high mammographic density is one of the strongest predictors of breast cancer risk, X-ray based mammography cannot be performed before the recommended screening age, especially not in adolescents and young women. Therefore, new techniques for breast density measurement are of interest. In this pilot study in Guam and Hawaii, we evaluated a radiation-free, bioimpedance device called Electrical Breast DensitometerTM (EBD; senoSENSE Medical Systems, Inc., Ontario, Canada) for measuring breast density in 95 women aged 31-82 years and 41 girls aged 8-18 years...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/26084210/adolescent-dietary-vitamin-d-and-sun-exposure-in-relation-to-benign-breast-disease
#17
Caroline E Boeke, Rulla M Tamimi, Catherine S Berkey, Graham A Colditz, Edward Giovannucci, Susan Malspeis, Walter C Willett, A Lindsay Frazier
PURPOSE: Vitamin D may reduce cell proliferation and tumor growth in breast tissue, and exposure may be most important during adolescence when breast tissue is developing. In the Nurses' Health Study II, higher recalled adolescent vitamin D intake was associated with a lower risk of benign breast disease (BBD). Our study aimed to assess adolescent vitamin D exposure in relation to BBD in young women. METHODS: Vitamin D was assessed in 6,593 adolescent girls (9-15 years of age at baseline) in the prospective Growing Up Today Study cohort using the mean energy-adjusted intakes from food frequency questionnaires in 1996, 1997, and 1998...
August 2015: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/26046606/bone-density-and-timing-of-puberty-in-a-longitudinal-study-of-girls
#18
Ashley M Cattran, Heidi J Kalkwarf, Susan M Pinney, Bin Huang, Frank M Biro
STUDY OBJECTIVE: Primary: To examine the relationship between relative timing of puberty with bone mineral density (BMD) in a group of adolescent girls; Secondary: To determine if family history of breast cancer was associated with bone mineral density. DESIGN/SETTING/PARTICIPANTS: Longitudinal study of girls recruited between 6 and 7 years of age seen every 6 months for 5 years, and subsequently seen annually. BMD of the lumbar spine was measured by dual-energy X-ray absorptiometry (DXA) at mean age of 12...
June 2015: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/25850589/breast-disorders-in-girls-and-adolescents-is-there-a-need-for-a-specialized-service
#19
Lina Michala, Alexandra Tsigginou, Dimitris Zacharakis, Constantine Dimitrakakis
INTRODUCTION: Minor breast concerns in childhood and adolescence are common and lead to increased anxiety among young patients and their families, particularly due to high correlation with breast cancer. However, most breast services aim at managing adults and triaging patients with breast cancer, whereas adolescent medicine specialists or pediatricians are usually not appropriately trained to identify and treat breast pathology. METHODS: We reviewed hospital records of all patients attending a pediatric and adolescent gynecology or breast clinic of a tertiary referral hospital, with a breast related symptom, between January 2009 and December 2011...
April 2015: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/25628346/sugar-sweetened-beverage-consumption-and-age-at-menarche-in-a-prospective-study-of-us-girls
#20
J L Carwile, W C Willett, D Spiegelman, E Hertzmark, J Rich-Edwards, A L Frazier, K B Michels
STUDY QUESTION: Is sugar-sweetened beverage (SSB) consumption associated with age at menarche? SUMMARY ANSWER: More frequent SSB consumption was associated with earlier menarche in a population of US girls. WHAT IS KNOWN ALREADY: SSB consumption is associated with metabolic changes that could potentially impact menarcheal timing, but direct associations with age at menarche have yet to be investigated. STUDY DESIGN, SIZE, DURATION: The Growing up Today Study, a prospective cohort study of 16 875 children of Nurses' Health Study II participants residing in all 50 US states...
March 2015: Human Reproduction
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