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https://www.readbyqxmd.com/read/29130619/a-feasibility-study-of-transaxillary-tavi-with-the-lotus-valve
#1
Sagar N Doshi, Sudhakar George, Chun Shing Kwok, Anthony Mechery, Mamas Mamas, Peter F Ludman, Jonathan N Townend, Moninder Bhabra
OBJECTIVES: To assess the feasibility of axillary transcatheter aortic valve implantation (TAVI) using the Lotus valve. BACKGROUND: TAVI is used to treat patients with severe aortic stenosis, with transfemoral (TF) access being the safest and most widely used route. In patients unsuitable for this, there are reports that the axillary artery may be safest alternative access route. The Lotus device is a fully retrievable 2nd generation transcatheter heart valve which is licensed for femoral and transaortic access...
November 11, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29126782/feasibility-and-limitations-of-mitral-valve-repair-with-or-without-left-ventricular-reconstruction-in-non-ischemic-dilated-cardiomyopathy
#2
Yasushige Shingu, Tomonori Ooka, Hiroki Katoh, Tsuyoshi Tachibana, Suguru Kubota, Yoshiro Matsui
BACKGROUND: Although non-transplant surgical interventions for non-ischemic dilated cardiomyopathy (NIDCM) are relatively effective, their feasibility and limitations have not been fully elucidated. The aim of this study was to define the feasibility and limitations of mitral valve repair, with or without surgical ventricular reconstruction for patients with NIDCM in terms of postoperative low cardiac output syndrome (LOS). METHODS: Twenty non-transplant candidates (aged 57±13 years) with NIDCM and significant mitral regurgitation had undergone mitral valve repair combined with submitral procedures...
November 7, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29118944/cardiac-progenitor-cells-application-in-cardiovascular-disease
#3
REVIEW
Hassan Amini, Jafar Rezaie, Armin Vosoughi, Reza Rahbarghazi, Mohammad Nouri
Stem cells (SCs) have special potency to differentiate into different types of cells, especially cardiomyocytes. In order to demonstrate the therapeutic applications of these cells, various investigations are recently being developed. Cardiac progenitor cells are endogenous cardiac SCs that found to express tyrosine kinase receptors, c-Kit and other stemness features in adult heart, contributing to the regeneration of cardiac tissue after injury. This lineage is able to efficiently trans-differentiate into different cell types such as cardiomyocytes, endothelial cells, and smooth muscle cells...
2017: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/29118032/impact-of-nonoptimal-intakes-of-saturated-polyunsaturated-and-trans-fat-on-global-burdens-of-coronary-heart-disease
#4
(no author information available yet)
No abstract text is available yet for this article.
November 8, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29111398/multi-slice-ct-msct-imaging-in-pre-trans-catheter-aortic-valve-implantation-tavi-screening-how-to-perform-and-how-to-interpret
#5
REVIEW
George Latsios, Themistoklis N Spyridopoulos, Konstantinos Toutouzas, Andreas Synetos, George Trantalis, Konstantinos Stathogiannis, Vassiliki Penesopoulou, George Oikonomou, Elias Brountzos, Dimitrios Tousoulis
Aortic valve stenosis (AS) is the commonest valvular heart disease among elderly. Trans-catheter aortic valve implantation (TAVI) has become an established and effective alternative therapeutical procedure for inoperable and high risk patients with symptomatic AS. The procedural success is greatly dependent on a thorough pre- TAVI imaging screening. This requires a comprehensive and multi-modality approach, in which multi-slice computed tomography (MSCT) is the cornerstone in the selection of eligible patients, in choosing the appropriate prosthesis and its size, as well as in mapping the safest access route for the intervention...
October 27, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29105689/-feasibility-and-safety-of-right-subclavian-access-for-edwards-sapien-3-balloon-expandable-transcatheter-aortic-valve-implantation
#6
Alessandro Iadanza, Marco Solari, Enrico Tucci, Carlo Pierli
Despite the technical advancements in transcatheter aortic valve implantation (TAVI), this procedure in patients with peripheral artery disease remains challenging and requires a patient-tailored management by the Heart Team. In-depth assessment of the patient's vascular anatomy is of utmost importance for the management of TAVI procedures with the aim to use the less invasive approach according to the specific patient characteristics. The trans-subclavian approach should be the preferred option in patients with femoral arterial disease undergoing TAVI; however, self-expandable valves have potential limitations, as in case of ascending aorta dilation and high implantation...
October 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29100989/single-shot-late-gd-enhancement-imaging-of-myocardial-infarction-with-retrospectively-adjustable-contrast-and-heart-phase
#7
Tobias Wech, Johannes Tran-Gia, Felix Rützel, Thorsten Klink, Thorsten A Bley, Herbert Köstler
OBJECT: To enable a retrospective adjustment of image contrast and heart phase in inversion recovery prepared late gadolinium enhancement (LE) imaging in the myocardium. MATERIALS AND METHODS: After one inversion pulse, unsegmented data were acquired over multiple cardiac cycles using a radial spoiled gradient-echo sequence with golden angle increments between subsequent readouts. Model-based acceleration of parameter mapping (MAP) was combined with an image registration technique ("MOCO-MAP") to enable the reconstruction of images with arbitrary inversion time TI...
October 31, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29092127/iatrogenic-lutembacher-syndrome-after-percutaneous-mitral-commissurotomy
#8
Theodoros D Karamitsos, Chrysovalantou Nikolaidou, Athanasios Koutsakis, Kyriakos Anastasiadis, Charalambos Karvounis, Stavros Hadjimiltiades
Atrial septal defects (ASDs) are common immediately after percutaneous mitral commissurotomy (PMC). They are usually small, hemodynamically insignificant, and tend to decrease or disappear within 6 to 12 months. Herein, a case is described of persistent ASD in a patient with mitral valve stenosis who had undergone successful PMC three years previously. The patient had signs and symptoms of right heart failure and severe tricuspid regurgitation (TR) with borderline right ventricular systolic function on echocardiography, in addition to the ASD...
May 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29082512/cardiopulmonary-exercise-test-predicts-right-heart-catheterization
#9
Michele Correale, Lucia Tricarico, Armando Ferraretti, Ilenia Monaco, Morena Concilio, Giuseppina Padovano, Gianfranco Acanfora, Matteo Di Biase, Natale Daniele Brunetti
BACKGROUND: Right heart catheterization (RHC) is usually required to confirm the diagnosis of pulmonary artery hypertension (PAH). As an invasive test, RHC may be associated with possible complications; so, non-invasive parameters able to predict PAH at RHC would be extremely useful. AIM: To ascertain possible correlations between cardiopulmonary exercise testing (CPET) and hemodynamic parameters at RHC indicative of PH. METHODS: Thirty-six consecutive outpatients with suspect of PAH underwent CPET and RHC; the intercept of ventilation (VEint) on the VE vs...
October 30, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29074945/analysis-commons-a-team-approach-to-discovery-in-a-big-data-environment-for-genetic-epidemiology
#10
Jennifer A Brody, Alanna C Morrison, Joshua C Bis, Jeffrey R O'Connell, Michael R Brown, Jennifer E Huffman, Darren C Ames, Andrew Carroll, Matthew P Conomos, Stacey Gabriel, Richard A Gibbs, Stephanie M Gogarten, Namrata Gupta, Cashell E Jaquish, Andrew D Johnson, Joshua P Lewis, Xiaoming Liu, Alisa K Manning, George J Papanicolaou, Achilleas N Pitsillides, Kenneth M Rice, William Salerno, Colleen M Sitlani, Nicholas L Smith, Susan R Heckbert, Cathy C Laurie, Braxton D Mitchell, Ramachandran S Vasan, Stephen S Rich, Jerome I Rotter, James G Wilson, Eric Boerwinkle, Bruce M Psaty, L Adrienne Cupples
No abstract text is available yet for this article.
October 27, 2017: Nature Genetics
https://www.readbyqxmd.com/read/29063567/best-paper-selection
#11
(no author information available yet)
Agarwal V, Podchiyska T, Banda JM, Goel V, Leung TI, Minty EP, Sweeney TE, Gyang E, Shah NH. Learning statistical models of phenotypes using noisy labeled training data. J Am Med Inform Assoc 2016;23(6):1166-73 https://academic.oup.com/jamia/article-lookup/doi/10.1093/jamia/ocw028 Harmanci A, Gerstein M. Quantification of private information leakage from phenotype-genotype data: linking attacks. Nat Methods 2016;13(3):251-6 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834871/ Pfiffner PB, Pinyol I, Natter MD, Mandl KD...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29063551/best-paper-selection
#12
(no author information available yet)
Arnold CW, Wallace WD, Chen S, Oh A, Abtin F, Genshaft S, Binder S, Aberle D, Enzmann D. RadPath: A web-based system for integrating and correlating radiology and pathology findings during cancer diagnosis. Acad Radiol 2016 Jan;23(1):90-100 http://escholarship.org/uc/item/22x4021q Hravnak M, Chen L, Dubrawski A, Bose E, Clermont G, Pinsky MR. Real alerts and artifact classification in archived multi-signal vital sign monitoring data: implications for mining big data. J Clin Monit Comput 2016 Dec;30(6):875-88 https://link...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29062742/long-term-outcomes-and-prosthesis-performance-after-transcatheter-aortic-valve-replacement-results-of-self-expandable-and-balloon-expandable-transcatheter-heart-valves
#13
Giuseppe Tarantini, Paola A M Purita, Augusto D'Onofrio, Chiara Fraccaro, Anna Chiara Frigo, Gianpiero D'Amico, Luca Nai Fovino, Marta Martin, Francesco Cardaioli, Mostafa R A Badawy, Massimo Napodano, Gino Gerosa, Sabino Iliceto
BACKGROUND: Data on transcatheter aortic valve replacement (TAVR) long-term clinical outcomes and hemodynamic performance of the self-expandable CoreValve (CV) and the balloon-expandable Edwards SAPIEN XT (ES) (Edwards Lifesciences, Irvine, California, USA) transcatheter heart valves (THV) are limited. Therefore, this study aimed to compare long-term clinical outcome data and hemodynamic performance of TAVR with either CV or ES. METHODS: We reviewed prospectively collected data of 171 patients treated with TAVR for severe aortic stenosis (AS) at our center between June 2007 and December 2010, with last follow-up contact in 2016...
September 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29055879/computed-tomography-fistulography-of-the-sternum-a-case-report-on-interprofessional-collaboration-between-radiologist-and-surgeon
#14
Mine Onat, Per Hostrup Nielsen, Henrik Jensen
INTRODUCTION: Trans sternal fistula can occur after sternotomy/heart surgery. Diagnosing this can be difficult. PRESENTATION OF CASE: In this report, we present a unique case of a patient with infection of an ascending aortic prosthetic graft. This patient was oozing from the wound despite several revisions. Many fistulographies were performed before fistulography with surgeon and radiologist revealed a trans sternal fistula. DISCUSSION: Infection with Propionibacterium acnes is often difficult to diagnose...
October 4, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29049838/predicting-long-term-survival-after-coronary-artery-bypass-graft-surgery
#15
Md N Karim, Christopher M Reid, Mollah Huq, Samuel L Brilleman, Andrew Cochrane, Lavinia Tran, Baki Billah
OBJECTIVES: To develop a model for predicting long-term survival following coronary artery bypass graft surgery. METHODS: This study included 46 573 patients from the Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZCTS) registry, who underwent isolated coronary artery bypass graft surgery between 2001 and 2014. Data were randomly split into development (23 282) and validation (23 291) samples. Cox regression models were fitted separately, using the important preoperative variables, for 4 'time intervals' (31-90 days, 91-365 days, 1-3 years and >3 years), with optimal predictors selected using the bootstrap bagging technique...
October 6, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29046868/inactive-trans-sialidase-expression-in-its-null-trypanosoma-cruzi-generates-virulent-trypomastigotes
#16
Carla A Pascuale, Juan M Burgos, Miriam Postan, Andrés B Lantos, Adriano Bertelli, Oscar Campetella, M Susana Leguizamón
Disclosing virulence factors from pathogens is required to better understand the pathogenic mechanisms involved in their interaction with the host. In the case of Trypanosoma cruzi several molecules are associated with virulence. Among them, the trans-sialidase (TS) has arisen as one of particular relevance due to its effect on the immune system and involvement in the interaction/invasion of the host cells. The presence of conserved genes encoding for an inactive TS (iTS) isoform is puzzlingly restricted to the genome of parasites from the Discrete Typing Units TcII, TcV, and TcVI, which include highly virulent strains...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29040269/elevated-blood-pressure-and-risk-of-mitral-regurgitation-a-longitudinal-cohort-study-of-5-5-million-united-kingdom-adults
#17
Kazem Rahimi, Hamid Mohseni, Catherine M Otto, Nathalie Conrad, Jenny Tran, Milad Nazarzadeh, Mark Woodward, Terence Dwyer, Stephen MacMahon
BACKGROUND: Mitral regurgitation in people without prior cardiac disease is considered a degenerative disease with no established risk factors for its prevention. We aimed to test the hypothesis that elevated systolic blood pressure (SBP) across its usual spectrum is associated with higher risk of mitral regurgitation. METHODS AND FINDINGS: We used linked electronic health records from the United Kingdom Clinical Practice Research Datalink (CPRD) from 1 January 1990 to 31 December 2015...
October 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29034473/development-and-maturation-of-the-fibrous-components-of-the-arterial-roots-in-the-mouse-heart
#18
Rachel Richardson, Lorraine Eley, Charlotte Donald-Wilson, Jonathon Davis, Natasha Curley, Ahlam Alqahtani, Lindsay Murphy, Robert H Anderson, Deborah J Henderson, Bill Chaudhry
The arterial roots are important transitional regions of the heart, connecting the intrapericardial components of the aortic and pulmonary trunks with their ventricular outlets. They house the arterial (semilunar) valves and, in the case of the aorta, are the points of coronary arterial attachment. Moreover, because of the semilunar attachments of the valve leaflets, the arterial roots span the anatomic ventriculo-arterial junction. By virtue of this arrangement, the interleaflet triangles, despite being fibrous, are found on the ventricular aspect of the root and located within the left ventricular cavity...
October 15, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/29033305/machine-learning-of-human-pluripotent-stem-cell-derived-engineered-cardiac-tissue-contractility-for-automated-drug-classification
#19
Eugene K Lee, David D Tran, Wendy Keung, Patrick Chan, Gabriel Wong, Camie W Chan, Kevin D Costa, Ronald A Li, Michelle Khine
Accurately predicting cardioactive effects of new molecular entities for therapeutics remains a daunting challenge. Immense research effort has been focused toward creating new screening platforms that utilize human pluripotent stem cell (hPSC)-derived cardiomyocytes and three-dimensional engineered cardiac tissue constructs to better recapitulate human heart function and drug responses. As these new platforms become increasingly sophisticated and high throughput, the drug screens result in larger multidimensional datasets...
November 14, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29032762/a-review-of-evolutionary-and-cyclical-changes-in-the-surgical-approach-to-aortic-valve-disease
#20
Marco Piciche, Guglielmo Actis Dato, Roberto Lorusso, Francesco Musumeci
INTRODUCTION: Aortic valve surgery is no exception to the general rule that history is a cycle in many fields. This manuscript aims to assist readers in transitioning from past to present and on into the future within the field of aortic valve surgery. METHODS: The existing literature has been examined, including old and modern articles published on pubmed, old articles non visible on pubmed, old and recent books on the history of medicine, looking for similarities and repetitions in techniques and surgical approaches to the aortic valve in the past and the current times...
October 9, 2017: Reviews on Recent Clinical Trials
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