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https://www.readbyqxmd.com/read/28516212/anatomical-visualization-of-neural-course-and-distribution-of-anterior-ascending-aortic-plexus
#1
Tomokazu Kawashima, Fumi Sato
The aim of this study was to document the detailed anatomy of neural course and distribution on the anterior ascending aorta, to identify the high and low density areas of the anterior ascending aortic plexus for further understandings in cardiovascular surgery. The embalmed hearts of 42 elderly individuals were submacroscopically and microscopically examined, after excluding any that were macroscopically abnormal. With its origins in the anterior ascending aortic plexus, the right coronary plexus substantially innervated the right coronary artery, the right atrium and ventricle, and the sinus node...
May 17, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28496031/atrial-septostomy-for-left-atrial-decompression-during-extracorporeal-membrane-oxygenation-by-inoue-balloon-catheter
#2
Yen-Nien Lin, Yin-Huei Chen, Huang-Joe Wang, Jui-Sung Hung, Kuan-Cheng Chang, Ping-Han Lo
BACKGROUND: Refractory pulmonary edema is an infrequent but serious complication in patients receiving venoarterial extracorporeal membrane oxygenation (VA-ECMO) for myocardial failure. Left atrial (LA) decompression in this setting is important. Although a few methods have been reported, the experience is mostly limited to children. We aimed to evaluate the feasibility of Inoue balloon catheter in percutaneous trans-septal LA decompression in adult cardiogenic patients.Methods and Results:We retrospectively analyzed 16 procedures of trans-septal LA decompression by Inoue balloon catheter in 15 VA-ECMO patients (aged 22-65 years, 6 men) with refractory pulmonary edema from May 2012 to December 2014...
May 11, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28490276/endometrial-stromal-and-epithelial-cells-exhibit-unique-aberrant-molecular-defects-in-patients-with-endometriosis
#3
Philip C Logan, Pamela Yango, Nam D Tran
CONTEXT: Endometriosis is a chronic inflammatory disease that causes pain and infertility in women of reproductive age. OBJECTIVE: To investigate the pathologic pathways in endometrial stromal and epithelial cells that contribute to the manifestation of endometriosis. DESIGN: In vitro cellular and molecular analyses of isolated eutopic endometrial stromal and epithelial cells. METHODS: Eutopic stromal and epithelial cells from endometriotic and normal patients were isolated by fluorescence-activated cell sorting for paired sibling RNA sequencing and microRNA microarray...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28487237/cytokines-affecting-cd4-t-regulatory-cells-in-transplant-tolerance-ii-interferon-gamma-ifn-%C3%AE-promotes-survival-of-alloantigen-specific-cd4-t-regulatory-cells
#4
Masaru Nomura, Suzanne J Hodgkinson, Giang T Tran, Nirupama D Verma, Catherine Robinson, Karren M Plain, Rochelle Boyd, Bruce M Hall
CD4(+)T cells that transfer alloantigen-specific transplant tolerance are short lived in culture unless stimulated with specific-donor alloantigen and lymphocyte derived cytokines. Here, we examined if IFN-γ maintained survival of tolerance transferring CD4(+)T cells. Alloantigen-specific transplant tolerance was induced in DA rats with heterotopic adult PVG heart allografts by a short course of immunosuppression and these grafts functioned for >100days with no further immunosuppression. In previous studies, we found the CD4(+)T cells from tolerant rats that transfer tolerance to an irradiated DA host grafted with a PVG heart, lose their tolerance transferring ability after 3days of culture, either with or without donor alloantigen, and effect rejection of specific-donor grafts...
May 6, 2017: Transplant Immunology
https://www.readbyqxmd.com/read/28484112/association-between-serum-elaidic-acid-concentration-and-insulin-resistance-in-two-japanese-cohorts-with-different-lifestyles
#5
Kiyotaka Itcho, Yoko Yoshii, Haruya Ohno, Kenji Oki, Masakazu Shinohara, Yasuhiro Irino, Ryuji Toh, Tatsuro Ishida, Ken-Ichi Hirata, Masayasu Yoneda
AIM: Many cohort studies have shown that increased trans fatty acid (TFA) intake increases the risk of developing coronary heart disease. However, whether TFA intake is directly associated with the development of diabetes mellitus (DM) remains unknown. METHODS: We performed the 75-g oral glucose tolerance test in two Japanese cohorts: a cohort of 454 native Japanese living in Hiroshima, Japan, and a cohort of 426 Japanese-Americans living in Los Angeles, USA, who shared identical genetic predispositions but had different lifestyles...
May 9, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28482326/constitutive-activation-of-nrf2-induces-a-stable-reductive-state-in-the-mouse-myocardium
#6
Gobinath Shanmugam, Madhusudhanan Narasimhan, Susan Tamowski, Victor Darley-Usmar, Namakkal S Rajasekaran
Redox homeostasis regulates key cellular signaling pathways in both physiology and pathology. The cell's antioxidant response provides a defense against oxidative stress and establishes a redox tone permissive for cell signaling. The molecular regulation of the well-known Keap1/Nrf2 system acts as sensor responding to changes in redox homeostasis and is poorly studied in the heart. Importantly, it is not yet known whether Nrf2 alone can serve as a master regulator of cellular redox homeostasis without compensation of the transcriptional regulation of antioxidant response element (ARE) genes through alternate mechanisms...
May 3, 2017: Redox Biology
https://www.readbyqxmd.com/read/28472396/chronic-activation-of-hypothalamic-oxytocin-neurons-improves-cardiac-function-during-left-ventricular-hypertrophy-induced-heart-failure
#7
Kara Garrott, Jhansi Dyavanapalli, Edmund Cauley, Mary Kate Dwyer, Sarah Kuzmiak-Glancy, Xin Wang, David Mendelowitz, Matthew Kay
AIMS: A distinctive hallmark of heart failure (HF) is autonomic imbalance, consisting of increased sympathetic activity and decreased parasympathetic tone. Recent work suggests that activation of hypothalamic oxytocin (OXT) neurons could improve autonomic balance during HF. We hypothesized that a novel method of chronic selective activation of hypothalamic OXT neurons will improve cardiac function and reduce inflammation and fibrosis in a rat model of HF. METHODS AND RESULTS: Two groups of male Sprague-Dawley rats underwent trans-ascending aortic constriction (TAC) to induce left ventricular (LV) hypertrophy that progresses to HF...
May 2, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28470999/access-to-the-native-atria-following-conduit-total-cavopulmonary-anastomosis
#8
Robert L Petersen, Saar Danon, Saadeh Jureidini
OBJECTIVES: We describe the use of trans-thoracic and trans-conduit puncture to access the atria and perform interventional procedures in patients who have undergone conduit total cavopulmonary anastomosis. BACKGROUND: Catheter access to the atria following intra or extra-cardiac Fontan is desirable when there is a need for trans-atrial interventions. METHODS: Between 2009 and 2014, 5 patients ages 7 to 28 years underwent this approach; three trans-thoracic and 2 trans-conduit punctures...
May 4, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28470925/modalities-and-effects-of-left-ventricle-unloading-on-extracorporeal-life-support-a-review-of-the-current-literature
#9
Paolo Meani, Sandro Gelsomino, Eshan Natour, Daniel M Johnson, Hans-Peter Brunner La Rocca, Federico Pappalardo, Elham Bidar, Maged Makhoul, Giuseppe Raffa, Samuel Heuts, Pieter Lozekoot, Suzanne Kats, Niels Sluijpers, Rick Schreurs, Thijs Delnoij, Alice Montalti, Jan Willem Sels, Marcel van de Poll, Paul Roekaerts, Thomas Poels, Eric Korver, Zaheer Babar, Jos Maessen, Roberto Lorusso
INTRODUCTION/AIM: Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) support is increasingly used in refractory cardiogenic shock and cardiac arrest, but is characterized by a rise in afterload of the left ventricle (LV) which may ultimately either further impair or delay cardiac contractility improvement. The aim of this study was to provide a comprehensive overview regarding the different LV venting techniques and results currently available in the literature. METHODS: A systematic literature search was performed in the PubMed database: 207 articles published between 1993 and 2016 were included...
May 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28469770/fgf-16-protects-against-adverse-cardiac-remodeling-in-the-infarct-diabetic-heart
#10
Yanyan Hu, Li Li, Lin Shen, Haiqing Gao, Fei Yu, Wenbin Yin, Wei Liu
Till now, no functional studies for FGF-16 in diabetic heart have been reported. Therefore, this study aims to evaluate the potential function of FGF-16 in inhibiting adverse cardiac remodeling in post myocardial infarction (MI) of diabetic heart. We investigated the role of fibroblast growth factor-16 (FGF-16) in post-MI remodeling and role of cardio-protection in the diabetic infarct heart. Adult db/db diabetic mice were assigned to sham group, MI group and MI+FGF-16 group, respectively. MI group was induced by permanent coronary artery ligation, and the mice were subjected to 2D trans-thoracic echocardiography 2-4 weeks post-surgery...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28457738/acromegalic-cardiomyopathy-with-malignant-arrhythmogenic-pattern-successfully-treated-with-mechanical-circulatory-support-and-heart-transplantation
#11
Sara Doimo, Daniela Miani, Nicoletta Finato, Mauro Driussi, Gianfranco Sinagra, Ugolino Livi, Alessandro Proclemer
Cardiovascular involvement is common in acromegaly and can lead to development of acromegalic cardiomyopathy, characterized by concentric biventricular hypertrophy with a progressive impairment of diastolic and systolic function. The onset of heart failure and arrhythmias are related to poor prognosis. We report on a case of a 48-year-old man with acromegalic cardiomyopathy caused by pituitary adenoma. Despite the successful trans-sphenoidal resection of the tumour, the patient was rehospitalized for ventricular arrhythmic storms that led to cardiogenic shock, which required mechanical hemodynamic support with intra-aortic balloon pump, venoarterial extracorporeal membrane oxygenation, and urgent heart transplantation...
February 21, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28457736/cost-of-congenital-heart-disease-hospitalizations-in-canada-a-population-based-study
#12
Andrew S Mackie, Dat T Tran, Ariane J Marelli, Padma Kaul
BACKGROUND: The prevalence of congenital heart disease (CHD) is rising, and late complications are common. The impact of these factors on health-care costs is not well understood. We sought to describe inpatient CHD costs in Canada. METHODS: We conducted an observational retrospective cohort study. The Canadian Institute for Health Information (CIHI) Discharge Abstract Database was used for all Canadian provinces, except Quebec, between April 2004 and March 2014...
February 10, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28457227/nih-workshop-report-on-the-trans-agency-blood-brain-interface-workshop-2016-exploring-key-challenges-and-opportunities-associated-with-the-blood-brain-and-their-interface
#13
REVIEW
Margaret J Ochocinska, Berislav V Zlokovic, Peter C Searson, A Tamara Crowder, Richard P Kraig, Julia Y Ljubimova, Todd G Mainprize, William A Banks, Ronald Q Warren, Andrei Kindzelski, William Timmer, Christina H Liu
A trans-agency workshop on the blood-brain interface (BBI), sponsored by the National Heart, Lung and Blood Institute, the National Cancer Institute and the Combat Casualty Care Research Program at the Department of Defense, was conducted in Bethesda MD on June 7-8, 2016. The workshop was structured into four sessions: (1) blood sciences; (2) exosome therapeutics; (3) next generation in vitro blood-brain barrier (BBB) models; and (4) BBB delivery and targeting. The first day of the workshop focused on the physiology of the blood and neuro-vascular unit, blood or biofluid-based molecular markers, extracellular vesicles associated with brain injury, and how these entities can be employed to better evaluate injury states and/or deliver therapeutics...
May 1, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28451804/assessment-of-late-cardiomyopathy-by-magnetic-resonance-imaging-in-patients-with-acute-promyelocytic-leukaemia-treated-with-all-trans-retinoic-acid-and-idarubicin
#14
Rebeca Rodríguez-Veiga, Begoña Igual, Pau Montesinos, Mar Tormo, Mª José Sayas, Mariano Linares, José María Fernández, Antonio Salvador, Alicia Maceira-González, Jordi Estornell, Marisa Calabuig, María Pedreño, Mónica Roig, Jaime Sanz, Guillermo Sanz, Carlos Carretero, Blanca Boluda, David Martínez-Cuadrón, Miguel Ángel Sanz
Late cardiomyopathy CMP is regarded as a potential severe long-term complication after anthracycline-based regimens for acute promyelocitic leukaemia (APL). We assess by MRI the incidence and severity of clinical and subclinical long-term CMP in a cohort of adult APL patients in first complete remission with PETHEMA trials. Adult patients diagnosed with APL in first complete remission lasting ≥2 years underwent anamnesis and physical examination and were asked to perform a cardiac MRI. Clinical CMP was defined as radiographic and physical signs of heart failure accompanied by symptoms or by left ventricle ejection fraction (LVEF) <45% by MRI with or without symptoms...
April 28, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28448503/etiologic-effects-and-optimal-intakes-of-foods-and-nutrients-for-risk-of-cardiovascular-diseases-and-diabetes-systematic-reviews-and-meta-analyses-from-the-nutrition-and-chronic-diseases-expert-group-nutricode
#15
Renata Micha, Masha L Shulkin, Jose L Peñalvo, Shahab Khatibzadeh, Gitanjali M Singh, Mayuree Rao, Saman Fahimi, John Powles, Dariush Mozaffarian
BACKGROUND: Dietary habits are major contributors to coronary heart disease, stroke, and diabetes. However, comprehensive evaluation of etiologic effects of dietary factors on cardiometabolic outcomes, their quantitative effects, and corresponding optimal intakes are not well-established. OBJECTIVE: To systematically review the evidence for effects of dietary factors on cardiometabolic diseases, including comprehensively assess evidence for causality; estimate magnitudes of etiologic effects; evaluate heterogeneity and potential for bias in these etiologic effects; and determine optimal population intake levels...
2017: PloS One
https://www.readbyqxmd.com/read/28448002/measurement-of-t-cell-alloreactivity-using-imaging-flow-cytometry
#16
Stephen C Juvet, Sajad Moshkelgosha, Sharon Sanderson, Joanna Hester, Kathryn J Wood, Andrew Bushell
The measurement of immunological reactivity to donor antigens in transplant recipients is likely to be crucial for the successful reduction or withdrawal of immunosuppression. The mixed leukocyte reaction (MLR), limiting dilution assays, and trans-vivo delayed-type hypersensitivity (DTH) assay have all been applied to this question, but these methods have limited predictive ability and/or significant practical limitations that reduce their usefulness. Imaging flow cytometry is a technique that combines the multiparametric quantitative powers of flow cytometry with the imaging capabilities of fluorescent microscopy...
April 19, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28441847/-feasibility-of-device-closure-for-multiple-atrial-septal-defects-using-3d-printing-and-ultrasound-guided-intervention-technique
#17
X Qiu, B Lü, N Xu, C W Yan, W B Ouyang, Y Liu, F W Zhang, Z Q Yue, K J Pang, X B Pan
Objective: To investigate the feasibility of trans-catheter closure of multiple atrial septal defects (ASD) monitored by trans-thoracic echocardiography (TTE) under the guidance of 3D printing heart model. Methods: Between April and August 2016, a total of 21 patients (8 male and 13 female) with multiple ASD in Fuwai Hospital of Chinese Academy of Medical Sciences underwent CT scan and 3-dimensional echocardiography for heart disease model produced by 3D printing technique. The best occlusion program was determined through the simulation test on the model...
April 25, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28441400/a-genomics-approach-identifies-selective-effects-of-trans-resveratrol-in-cerebral-cortex-neuron-and-glia-gene-expression
#18
Gemma Navarro, Eva Martínez-Pinilla, Alejandro Sánchez-Melgar, Raquel Ortiz, Véronique Noé, Mairena Martín, Carlos Ciudad, Rafael Franco
The mode of action of trans-resveratrol, a promising lead compound for the development of neuroprotective drugs, is unknown. Data from a functional genomics study were retrieved with the aim to find differentially expressed genes that may be involved in the benefits provided by trans-resveratrol. Genes that showed a significantly different expression (p<0.05, cut-off of a two-fold change) in mice fed with a control diet or a control diet containing trans-resveratrol were different in cortex, heart and skeletal muscle...
2017: PloS One
https://www.readbyqxmd.com/read/28441235/noninvasive-iphone-measurement-of-left-ventricular-ejection-fraction-using-intrinsic-frequency-methodology
#19
Niema M Pahlevan, Derek G Rinderknecht, Peyman Tavallali, Marianne Razavi, Thao T Tran, Michael W Fong, Robert A Kloner, Marie Csete, Morteza Gharib
OBJECTIVE: The study is based on previously reported mathematical analysis of arterial waveform that extracts hidden oscillations in the waveform that we called intrinsic frequencies. The goal of this clinical study was to compare the accuracy of left ventricular ejection fraction derived from intrinsic frequencies noninvasively versus left ventricular ejection fraction obtained with cardiac MRI, the most accurate method for left ventricular ejection fraction measurement. DESIGN: After informed consent, in one visit, subjects underwent cardiac MRI examination and noninvasive capture of a carotid waveform using an iPhone camera (The waveform is captured using a custom app that constructs the waveform from skin displacement images during the cardiac cycle...
April 22, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28424192/sodium-sugar-and-fat-content-of-complementary-infant-and-toddler-foods-sold-in-the-united-states-2015
#20
Joyce Maalouf, Mary E Cogswell, Marlana Bates, Keming Yuan, Kelley S Scanlon, Pamela Pehrsson, Janelle P Gunn, Robert K Merritt
Background: As part of a healthy diet, limiting intakes of excess sodium, added sugars, saturated fat, and trans fat has been recommended. The American Heart Association recommends that children aged <2 y should avoid added sugars.Objective: We sought to determine commercial complementary infant-toddler food categories that were of potential concern because of the sodium, added sugar, saturated fat, or trans fat content.Design: Nutrition label information (e.g., serving size, sodium, saturated fat, trans fat) for 1032 infant and toddler foods was collected from manufacturers' websites and stores from May to July 2015 for 24 brands, which accounted for >95% of infant-toddler food sales...
April 19, 2017: American Journal of Clinical Nutrition
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