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https://www.readbyqxmd.com/read/28213895/safety-of-implantation-of-a-leadless-pacemaker-via-femoral-approach-in-the-presence-of-an-inferior-vena-cava-filter
#1
Muhammad R Afzal, Janice Ackers, John D Hummel, Ralph Augostini
A 61-year-old woman with symptomatic complete heart block was referred for permanent pacemaker. The presence of a left sided arteriovenous fistula and right sided mastectomy with lymph node dissection precluded the implantation of a trans-venous pacemaker and therefore, a leadless pacemaker was recommended. The patient also had an inferior vena cava (IVC) filter. The passage of a 27 French introducer sheath housing the leadless pacemaker through IVC filter was carefully visualized under fluoroscopy and advanced to the right ventricle without any compromise to the filter...
February 17, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28205462/atypical-chronic-myeloid-leukemia-in-a-german-shepherd-dog
#2
Christina L Marino, Jimmy N S N Tran, Tracy Stokol
A 4-y-old neutered male German Shepherd Dog was presented with a 3-d duration of lethargy, restlessness, and vomiting. Physical examination revealed generalized lymphadenopathy, pale mucous membranes, systolic heart murmur, dehydration, and fever. Hematologic abnormalities included moderate-to-marked leukocytosis, characterized by neutrophilia with a left shift to progranulocytes and 2% presumptive myeloid blasts, marked anemia that was nonregenerative, and marked thrombocytopenia. Dysplasia was evident in neutrophils and platelets...
February 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28203542/robotic-trans-atrial-and-trans-mitral-ventricular-septal-resection
#3
REVIEW
W Randolph Chitwood
Localized ventricular septal hypertrophy, also known as idiopathic hypertrophic subaortic stenosis or idiopathic hypertrophic subaortic septal obstruction (IHSS), can create severe ventricular outflow obstruction. This often results in a high sub-aortic pressure gradient with potentially lethal symptoms. In 1960, Braunwald described the hemodynamic characteristics of IHSS, and thereafter, Morrow developed a trans-aortic approach to resect a large part of the ventricular septum, enlarging the outflow tract. The Morrow operation has remained the gold standard for surgically treating this pathology...
January 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28195938/low-adverse-event-rates-but-high-emergency-department-utilization-in-chest-pain-patients-treated-in-an-emergency-department-observation-unit
#4
Anthony M Napoli, Janette Baird, Steven Tran, Jing Wang
OBJECTIVES: Nearly 40% of all previously admitted chest pain patients re-present to the emergency department (ED) within 1 year regardless of stress testing, and nearly 5% of patients return with a major adverse cardiac event (MACE). The primary objective of this study was to determine the prevalence of return visits to the ED among patients previously admitted to an ED chest pain observation unit (CPU). We also identified the patient characteristics and health risk factors associated with these return ED visits...
March 2017: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/28179397/dipeptidyl-peptidase-4-induces-aortic-valve-calcification-by-inhibiting-insulin-like-growth-factor-1-signaling-in-valvular-interstitial-cells
#5
Bongkun Choi, Sahmin Lee, Sang-Min Kim, Eun-Jin Lee, Sun Ro Lee, Dae-Hee Kim, Jeong Yoon Jang, Sang-Wook Kang, Ki-Up Lee, Eun-Ju Chang, Jae-Kwan Song
Background -Calcification of the aortic valve leads to increased leaflet stiffness, and consequently to the development of calcific aortic valve disease (CAVD); however, the underlying molecular and cellular mechanisms of calcification remain unclear. Here, we identified that dipeptidyl peptidase-4 (DPP-4, also known as CD26) increases valvular calcification and promotes CAVD progression. Methods -We obtained the aortic valve tissues from humans and murine models (wild type and eNOS(-/-) mice), and cultured the valvular interstitial cells (VICs) and valvular endothelial cells (VECs) from the cusps...
February 8, 2017: Circulation
https://www.readbyqxmd.com/read/28162931/efficacy-of-a-medication-adherence-enhancing-intervention-in-transplantation-the-maestro-tx-trial
#6
Fabienne Dobbels, Leentje De Bleser, Lut Berben, Paulus Kristanto, Lieven Dupont, Frederik Nevens, Johan Vanhaecke, Geert Verleden, Sabina De Geest
BACKGROUND: Well-designed randomized controlled trials (RCTs) testing efficacy of post-transplant medication adherence enhancing interventions and clinical outcomes are scarce. METHODS: This randomized controlled trial enrolled adult heart, liver, and lung transplant recipients who were >1 year post-transplant and on tacrolimus twice daily (convenience sample) (visit 1). After a 3-month run-in period, patients were randomly assigned 1:1 to intervention group (IG) or control group (CG) (visit 2), followed by a 6-month intervention (visits 2-4) and a 6-month adherence follow-up period (visit 5)...
January 6, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28160405/distribution-of-trans-resveratrol-and-its-metabolites-after-acute-or-sustained-administration-in-mouse-heart-brain-and-liver
#7
Marie-Claude Menet, Stephanie Baron, Meryam Taghi, Remi Diestra, Delphine Dargère, Olivier Laprévote, Valérie Nivet-Antoine, Jean-Louis Beaudeux, Tatiana Bédarida, Charles-Henry Cottart
SCOPE: Trans-resveratrol is widely studied for its potentially beneficial effects on numerous disorders. It is rapidly metabolized and its metabolites can exhibit biological activity. The present study aimed to investigate whether acute or sustained trans-resveratrol administration impacted on the distribution of trans-resveratrol and its metabolites in brain, heart, and liver. METHODS AND RESULTS: We used UHPLC-Q-TOF in full-scan mode to identify and assess large numbers of resveratrol metabolites...
February 3, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28157155/disparate-effects-of-stilbenoid-polyphenols-on-hypertrophic-cardiomyocytes-in-vitro-vs-in-the-spontaneously-hypertensive-heart-failure-rat
#8
Bolanle C Akinwumi, Pema Raj, Danielle I Lee, Crystal Acosta, Liping Yu, Samuel M Thomas, Kalyanam Nagabhushanam, Muhammed Majeed, Neal M Davies, Thomas Netticadan, Hope D Anderson
Stilbenoids are bioactive polyphenols, and resveratrol (trans-3,5,40-trihydroxystilbene) is a representative stilbenoid that reportedly exerts cardioprotective actions. As resveratrol exhibits low oral bioavailability, we turned our attention to other stilbenoid compounds with a history of medicinal use and/or improved bioavailability. We determined the effects of gnetol (trans-3,5,20,60-tetrahydroxystilbene) and pterostilbene (trans-3,5-dimethoxy-40-hydroxystilbene) on cardiac hypertrophy. In vitro, gnetol and pterostilbene prevented endothelin-1-induced indicators of cardiomyocyte hypertrophy including cell enlargement and protein synthesis...
February 1, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28149706/evaluation-of-epidemiological-clinical-and-microbiological-features-of-definite-infective-endocarditis
#9
Reza Faraji, Mostafa Behjati-Ardakani, Seyed Mohammad Moshtaghioun, Seyed Mehdi Kalantar, Seyedeh Mahdieh Namayandeh, Mohammadhossien Soltani, Hengameh Zandi, Ali Dehghani Firoozabadi, Neda Tavakkoli Banizi, Foroozandeh Qasemi Kahtooie, Mehdi Banaei, Mohammadtaghi Sarebanhassanabadi
Background: Infective endocarditis (IE) is a microbial infection of heart valves and its endothelial lining which is considered as a life-threatening disorder. This study evaluated the epidemiological, clinical, and microbiological features of IE at the Cardiovascular Research Center in Yazd, Iran. Methods: The cross-sectional study was conducted on 20 patients diagnosed with definite IE on the basis of Duke's criteria hospitalized for one year in the Cardiovascular Research Center in Yazd, Iran, from January 2015 to December 2015...
2017: GMS Hygiene and Infection Control
https://www.readbyqxmd.com/read/28147377/case-report-acute-flair-of-ulcerative-colitis-during-pregnancy-is-still-a-major-problem
#10
Marijana Protic, Srdjan Markovic, Dino Tarabar
Although severe flare of ulcerative colitis (UC) is uncommon, it significantly increases the risk of preterm delivery, low birth weight and other adverse fetal outcomes. It is critical to optimize aggressive medical treatment with both mother and fetal health. Here, we present a case of a 30-year-old woman with a severe flare of UC at the 16th gestational week. The diagnosis of extensive UC was established 8 years ago. From the time she was diagnosed, she had 5 moderate flares successfully treated with oral and topical mesalamine...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/28138529/epidermal-mechano-acoustic-sensing-electronics-for-cardiovascular-diagnostics-and-human-machine-interfaces
#11
Yuhao Liu, James J S Norton, Raza Qazi, Zhanan Zou, Kaitlyn R Ammann, Hank Liu, Lingqing Yan, Phat L Tran, Kyung-In Jang, Jung Woo Lee, Douglas Zhang, Kristopher A Kilian, Sung Hee Jung, Timothy Bretl, Jianliang Xiao, Marvin J Slepian, Yonggang Huang, Jae-Woong Jeong, John A Rogers
Physiological mechano-acoustic signals, often with frequencies and intensities that are beyond those associated with the audible range, provide information of great clinical utility. Stethoscopes and digital accelerometers in conventional packages can capture some relevant data, but neither is suitable for use in a continuous, wearable mode, and both have shortcomings associated with mechanical transduction of signals through the skin. We report a soft, conformal class of device configured specifically for mechano-acoustic recording from the skin, capable of being used on nearly any part of the body, in forms that maximize detectable signals and allow for multimodal operation, such as electrophysiological recording...
November 2016: Science Advances
https://www.readbyqxmd.com/read/28132808/store-operated-ca-2-entry-controls-induction-of-lipolysis-and-the-transcriptional-reprogramming-to-lipid-metabolism
#12
Mate Maus, Mario Cuk, Bindi Patel, Jayson Lian, Mireille Ouimet, Ulrike Kaufmann, Jun Yang, Rita Horvath, Hue-Tran Hornig-Do, Zofia M Chrzanowska-Lightowlers, Kathryn J Moore, Ana Maria Cuervo, Stefan Feske
Ca(2+) signals were reported to control lipid homeostasis, but the Ca(2+) channels and pathways involved are largely unknown. Store-operated Ca(2+) entry (SOCE) is a ubiquitous Ca(2+) influx pathway regulated by stromal interaction molecule 1 (STIM1), STIM2, and the Ca(2+) channel ORAI1. We show that SOCE-deficient mice accumulate pathological amounts of lipid droplets in the liver, heart, and skeletal muscle. Cells from patients with loss-of-function mutations in STIM1 or ORAI1 show a similar phenotype, suggesting a cell-intrinsic role for SOCE in the regulation of lipid metabolism...
January 21, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28130202/sub-cellular-localization-specific-sumoylation-in-the-heart
#13
Nhat-Tu Le, James F Martin, Keigi Fujiwara, Jun-Ichi Abe
Although the majority of SUMO substrates are localized in the nucleus, SUMOylation is not limited to nuclear proteins and can be also detected in extra-nuclear proteins. In this review, we will highlight and discuss how SUMOylation in different cellular compartments regulate biological processes. First, we will discuss the key role of SUMOylation of proteins in the extra-nuclear compartment in cardiomyocytes, which is overwhelmingly cardio-protective. On the other hand, SUMOylation of nuclear proteins is generally detrimental to the cardiac function mainly because of the trans-repressive nature of SUMOylation on many transcription factors...
January 24, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28123309/improvement-of-impaired-diastolic-left-ventricular-function-after-diet-induced-weight-reduction-in-severe-obesity
#14
Sevda Karimian, Juergen Stein, Boris Bauer, Claudius Teupe
BACKGROUND/OBJECTIVES: Obesity is independently associated with left ventricular (LV) diastolic dysfunction and altered cardiac morphology. Morbidity and mortality in patients with diastolic dysfunction are similar to values observed in patients with systolic heart failure. We hypothesized that dysfunctional cardiac responses in people with obesity are reversible after weight loss. Thus, we studied the effect of dietary weight reduction on LV diastolic function as well as on cardiac structure using transthoracic echocardiography and tissue Doppler imaging (TDI)...
2017: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/28120364/evaluation-of-carotid-plaque-vulnerability-in-vivo-correlation-between-dynamic-contrast-enhanced-mri-and-mri-modified-aha-classification
#15
Xiaoqian Ge, Zien Zhou, Huilin Zhao, Xiao Li, Beibei Sun, Shiteng Suo, Maree L Hackett, Jieqing Wan, Jianrong Xu, Xiaosheng Liu
PURPOSE: To noninvasively monitor carotid plaque vulnerability by exploring the relationship between pharmacokinetic parameters (PPs) of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and plaque types based on MRI-modified American Heart Association (AHA) classification, as well as to assess the ability of PPs in discrimination between stable and vulnerable plaques suspected on MRI. MATERIALS AND METHODS: Of 70 consecutive patients with carotid plaques who volunteered for 3...
January 24, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28116551/tensor-factorization-for-precision-medicine-in-heart-failure-with-preserved-ejection-fraction
#16
Yuan Luo, Faraz S Ahmad, Sanjiv J Shah
Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous clinical syndrome that may benefit from improved subtyping in order to better characterize its pathophysiology and to develop novel targeted therapies. The United States Precision Medicine Initiative comes amid the rapid growth in quantity and modality of clinical data for HFpEF patients ranging from deep phenotypic to trans-omic data. Tensor factorization, a form of machine learning, allows for the integration of multiple data modalities to derive clinically relevant HFpEF subtypes that may have significant differences in underlying pathophysiology and differential response to therapies...
January 23, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28113792/identification-of-location-specific-feature-points-in-a-cardiac-cycle-using-a-novel-seismocardiogram-spectrum-system
#17
Wen-Yen Lin, Wen-Cheng Chou, Po-Cheng Chang, Chung-Chuan Chou, Ming-Shien Wen, Ming-Yun Ho, Wen-Chen Lee, Ming-Jer Hsieh, Chungchih Lin, Tsai-Hsuan Tsai, Ming-Yih Lee
Seismocardiogram (SCG) or Mechanocardiography (MCG) is a non-invasive cardiac diagnostic method; however, previous studies used only a single sensor to detect cardiac mechanical activities which will not be able to identify location-specific feature points in a cardiac cycle corresponding to the four valvular auscultation locations. In this study, a multi-channel SCG spectrum measurement system was proposed and examined for cardiac activity monitoring to overcome problems like, position dependency, time delay, and signal attenuation, occurring in traditional single channel SCG systems...
October 25, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28113394/4d-ice-a-2d-array-transducer-with-integrated-asic-in-a-10-fr-catheter-for-real-time-3d-intracardiac-echocardiography
#18
Douglas Wildes, Warren Lee, Bruno Haider, Scott Cogan, Krishnakumar Sundaresan, David Mills, Christopher Yetter, Patrick Hart, Christopher Haun, Mikael Concepcion, Johan Kirkhorn, Marc Bitoun
We developed a 2.5 x 6.6 mm 2D array transducer with integrated transmit/receive ASIC for 4D ICE (real-time 3D IntraCardiac Echocardiography) applications. The ASIC and transducer design were optimized so that the high voltage transmit, low-voltage TGC (time-gain control) and preamp, subaperture beamformer, and digital control circuits for each transducer element all fit within the 0.019 mm2 area of the element. The transducer assembly was deployed in a 10 Fr (3.3 mm diameter) catheter, integrated with a GE Vivid1 E9 ultrasound imaging system, and evaluated in three pre-clinical studies...
October 12, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28112757/reversal-of-maladaptive-fibrosis-and-compromised-ventricular-function-in-the-pressure-overloaded-heart-by-a-caveolin-1-surrogate-peptide
#19
Dorea Pleasant-Jenkins, Charles Reese, Panneerselvem Chinnakkannu, Harinath Kasiganesan, Elena Tourkina, Stanley Hoffman, Dhandapani Kuppuswamy
Chronic ventricular pressure overload (PO) results in congestive heart failure (CHF) in which myocardial fibrosis develops in concert with ventricular dysfunction. Caveolin-1 is important in fibrosis in various tissues due to its decreased expression in fibroblasts and monocytes. The profibrotic effects of low caveolin-1 can be blocked with the caveolin-1 scaffolding domain peptide (CSD, a caveolin-1 surrogate) using both mouse models and human cells. We have studied the beneficial effects of CSD on mice in which PO was induced by trans-aortic constriction (TAC)...
January 23, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28106762/contribution-of-trans-fatty-acid-intake-to-coronary-heart-disease-burden-in-australia-a-modelling-study
#20
Jason H Y Wu, Miaobing Zheng, Elise Catterall, Shauna Downs, Beth Thomas, Lennert Veerman, Jan J Barendregt
Trans-fatty acids (TFAs) intake has been consistently associated with a higher risk of coronary heart disease (CHD) mortality. We provided an updated assessment of TFA intake in Australian adults in 2010 and conducted modeling to estimate CHD mortality attributable to TFA intake. Data of the 2011-2012 National Nutrition and Physical Activity Survey was used to assess TFA intake. The CHD burden attributable to TFA was calculated by comparing the current level of TFA intake to a counterfactual setting where consumption was lowered to a theoretical minimum distribution of 0...
January 18, 2017: Nutrients
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