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Breast neoplam

Nurbek Igissinov, Saginbek Igissinov, Malcolm A Moore, Mazhit Shaidarov, Dmitriy Tereshkevich, Zarina Bilyalova, Gulnur Igissinova, Indira Nuralina, Saken Kozhakhmetov
The aim of this research was to examine the incidence of major forms of cancer in the Aral-Syr Darya ecological area of Kazakhstan. The present retrospective study of 11 years (1999-2009) was therefore conducted using descriptive and analytical methods. Incidence rates (crude and standardized) of 11 leading cancer sites were calculated and trends determined. The result of analysis demonstrated the most common neoplams in the study region to be esophageal cancer, carcinoma of lung, stomach cancer, and breast cancer...
2011: Asian Pacific Journal of Cancer Prevention: APJCP
Vittorio Pasta, Paolo Urcioli, Stella Chiarini, Massimo Vergine, Nino Favoriti, Elisabetta Santucci, Manuel Giofrè, Massimo Monti
AIM: The aim of the study was to considerate neoplams of ectopic breast tissue in particular concerning the diagnostic and surgical related problems, analysing our experience in this extremely rare pathology. MATERIALS AND METHODS: A group of five women affected by neoplasm of ectopic breast tissuehave been examinated, four of them in axillary breast tissue and the other one in parasternal area. They came to our clinical observation (UOC BCG 21, UOC BCG 27-Policlinico Umberto I,-Università "Sapienza" di Roma) between 2006 and 2008...
September 2009: Annali Italiani di Chirurgia
Norman L Lehman
Thymidylate synthase (TS) catalyses the de novo synthesis of deoxythymidylate and is a key rate-limiting enzyme of DNA synthesis. The primary site of action of the classic antifolate methotrexate is direct inhibition of dihydrofolate reductase, but it also inhibits TS indirectly by diminishing levels of the TS cosubstrate 5,10-methylenetetrahydrofolate. Polyglutamated metabolites of methotrexate also directly bind and inhibit TS. The prototype fluoropyrimidine fluorouracil is metabolised to an irreversible inhibitor of TS and is the standard chemotherapy for gastrointestinal carcinomas...
December 2002: Expert Opinion on Investigational Drugs
C Di Loreto, F M Reis, P Cataldi, C Zuiani, S Luisi, C A Beltrami, F Petraglia
OBJECTIVE: Inhibins and activins are members of the transforming growth factor beta superfamily and are known to modulate the growth and differentiation of several cell types. The present study investigated the localization of inhibin and activin subunits in human normal and pathological breast tissues. DESIGN: A cross-sectional study comparing the expression of inhibin/activin subunits alpha, betaA and betaB in surgical specimens from women undergoing reductive mammoplasty (classified, according to the phase of the menstrual cycle, as follicular, luteal, or postmenopausal), and patients submitted to lumpectomy for fibrocystic disease, benign (intraductal papilloma, adenomyoepithelioma, and hamartoma) or malignant breast neoplams (intraductal, intralobular, and invasive carcinoma)...
August 1999: European Journal of Endocrinology
A Wieczorkiewicz
No abstract text is available yet for this article.
November 20, 1967: Polski Tygodnik Lekarski
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