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https://www.readbyqxmd.com/read/28732156/fixed-bed-modeling-of-nonsteroidal-anti-inflammatory-drug-removal-by-ion-exchange-in-synthetic-urine-mass-removal-or-toxicity-reduction
#1
Kelly Ann Landry, Treavor H Boyer
Ion-exchange removal of nonsteroidal anti-inflammatory drugs (NSAIDs) in synthetic urine can selectively remove pharmaceuticals with minimal co-removal of nutrients to enhance nutrient recovery efforts. However, the effect of endogenous metabolites in urine on ion-exchange removal, and the corresponding reduction in ecotoxicity potential of pharmaceuticals in treated urine entering the environment, is unknown. To assess treatment efficacy, this work paired predicted breakthrough curves determined by the homogenous surface diffusion model to an in vitro bioassay to evaluate COX-1 inhibition...
July 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28728578/development-of-an-optimised-key-worker-framework-for-people-with-dementia-their-family-and-caring-unit-living-in-the-community
#2
Emma Renehan, Dianne Goeman, Susan Koch
BACKGROUND: In Australia, dementia is a national health priority. With the rising number of people living with dementia and shortage of formal and informal carers predicted in the near future, developing approaches to coordinating services in quality-focused ways is considered an urgent priority. Key worker support models are one approach that have been used to assist people living with dementia and their caring unit coordinate services and navigate service systems; however, there is limited literature outlining comprehensive frameworks for the implementation of community dementia key worker roles in practice...
July 20, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28727944/computer-based-case-simulations-for-assessment-in-health-care-a-literature-review-of-validity-evidence
#3
Robyn C Ward, Timothy J Muckle, Michael J Kremer, Mary Anne Krogh
Simulation for education and training in health-care professions has been widely applied. However, its value as an assessment tool for competence is not fully known. Logistical barriers of simulation-based assessments have led some health-care organizations to utilize computer-based case simulations (CCSs) for assessment. This article provides a review of the literature on the identification of psychometrically sound, CCS instruments designed to measure decision-making competence in health-care professionals...
January 1, 2017: Evaluation & the Health Professions
https://www.readbyqxmd.com/read/28727794/lie-construction-affects-information-storage-under-high-memory-load-condition
#4
Yuqiu Liu, Chunjie Wang, Haibo Jiang, Hongjian He, Feiyan Chen
Previous studies indicate that lying consumes cognitive resources, especially working memory (WM) resources. Considering the dual functions that WM might play in lying: holding the truth-related information and turning the truth into lies, the present study examined the relationship between the information storage and processing in the lie construction. To achieve that goal, a deception task based on the old/new recognition paradigm was designed, which could manipulate two levels of WM load (low-load task using 4 items and high-load task using 6 items) during the deception process...
2017: PloS One
https://www.readbyqxmd.com/read/28727271/the-effectiveness-of-an-initial-continuing-education-course-in-leadership-for-dentists
#5
P Roig Jornet, E Kalenderian
PURPOSE/OBJECTIVES: The purpose of this study was to measure the effectiveness of a continuing education course in leadership presented to postdoctoral dentist-leaders. METHODS: The authors developed a 3-day course on leadership and management with topics including self-awareness, leadership qualities, emotional intelligence, communication skills, social skills, conflict management, personal branding, quality improvement and team motivation. Twenty-two course participants with a median age of 37...
July 20, 2017: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/28727200/landscape-genetic-analyses-reveal-fine-scale-effects-of-forest-fragmentation-in-an-insular-tropical-bird
#6
Aurélie Khimoun, William Peterman, Cyril Eraud, Bruno Faivre, Nicolas Navarro, Stéphane Garnier
Within the framework of landscape genetics, resistance surface modelling is particularly relevant to explicitly test competing hypotheses about landscape effects on gene flow. To investigate how fragmentation of tropical forest affects population connectivity in a forest-specialist bird species, we optimized resistance surfaces without a priori specification, using least-cost (LCP) or resistance (IBR) distances. We implemented a two-step procedure in order i) to objectively define the landscape thematic resolution (level of detail in classification scheme to describe landscape variables) and spatial extent (area within the landscape boundaries) and then ii) to test the relative role of several landscape features (elevation, roads, land cover) in genetic differentiation in the Plumbeous Warbler (Setophaga plumbea)...
July 20, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28725268/towards-microalgal-triglycerides-in-the-commodity-markets
#7
Giulia Benvenuti, Jesús Ruiz, Packo P Lamers, Rouke Bosma, René H Wijffels, Maria J Barbosa
BACKGROUND: Microalgal triglycerides (TAGs) hold great promise as sustainable feedstock for commodity industries. However, to determine research priorities and support business decisions, solid techno-economic studies are essential. Here, we present a techno-economic analysis of two-step TAG production (growth reactors are operated in continuous mode such that multiple batch-operated stress reactors are inoculated and harvested sequentially) for a 100-ha plant in southern Spain using vertically stacked tubular photobioreactors...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28724352/a-permutation-based-non-parametric-analysis-of-crispr-screen-data
#8
Gaoxiang Jia, Xinlei Wang, Guanghua Xiao
BACKGROUND: Clustered regularly-interspaced short palindromic repeats (CRISPR) screens are usually implemented in cultured cells to identify genes with critical functions. Although several methods have been developed or adapted to analyze CRISPR screening data, no single specific algorithm has gained popularity. Thus, rigorous procedures are needed to overcome the shortcomings of existing algorithms. METHODS: We developed a Permutation-Based Non-Parametric Analysis (PBNPA) algorithm, which computes p-values at the gene level by permuting sgRNA labels, and thus it avoids restrictive distributional assumptions...
July 19, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28724149/using-reflections-to-evaluate-the-stfm-behavioral-science-family-systems-educator-fellowship
#9
Deborah A Taylor, Victoria Gorski, Sandra K Burge
BACKGROUND AND OBJECTIVES: A group of family medicine educators identified a need and developed a 1-year fellowship for early career behavioral science educators. This occurred in response to a reduction in previous opportunities and resources. The program was designed to shape and mentor new behavioral science faculty teaching in family medicine departments and programs. Quantitative data analysis from pre- and post-fellowship survey data from years 1-4 confirmed fellowship objectives were met...
July 2017: Family Medicine
https://www.readbyqxmd.com/read/28724017/food-risk-regulation-the-tensions-of-the-brazilian-health-surveillance-system
#10
Ana Virgínia Almeida Figueiredo, Elisabetta Recine, Renata Monteiro
This article addresses the dynamics of Brazilian food control practices, highlighting their special risk-related features and the types of intervention, as well as the recently adopted instruments to control risks related to the nutritional composition of food and their institutional repercussions. Food regulation in Brazil dates back to the First Republic. The practice has been remodeled over the years, due to both the increasing complexity of the risks and the introduction of new institutional operational mechanisms...
July 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28721168/cholera-outbreak-in-homa-bay-county-kenya-2015
#11
Jane Njoki Githuku, Waqo Gufu Boru, Casey Daniel Hall, Zeinab Gura, Elvis Oyugi, Rogath Saika Kishimba, Innocent Semali, Ghada Nadim Farhat, Meeyoung Mattie Park
Cholera is among the re-emerging diseases in Kenya. Beginning in December 2014, a persistent outbreak occurred involving 29 out of the 47 countries. Homa Bay County in Western Kenya was among the first counties to report cholera cases from January to April 2015. This case study is based on an outbreak investigation conducted by FELTP residents in Homa Bay County in February 2015. It simulates an outbreak investigation including laboratory confirmation, active case finding, descriptive epidemiology and implementation of control measures...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28721120/effective-learning-environments-the-process-of-creating-and-maintaining-an-online-continuing-education-tool
#12
Sharon Davies, Gianni Roberto Lorello, Kristi Downey, Zeev Friedman
Continuing medical education (CME) is an indispensable part of maintaining physicians' competency. Since attending conferences requires clinical absenteeism and is not universally available, online learning has become popular. The purpose of this study is to conduct a retrospective analysis examining the creation process of an anesthesia website for adherence to the published guidelines and, in turn, provide an illustration of developing accredited online CME. Using Kern's guide to curriculum development, our website analysis confirmed each of the six steps was met...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/28720468/production-of-a-chikungunya-vaccine-using-a-cho-cell-and-attenuated-viral-based-platform-technology
#13
Preethi Eldi, Tamara H Cooper, Liang Liu, Natalie A Prow, Kerrilyn R Diener, Paul M Howley, Andreas Suhrbier, John D Hayball
Vaccinia-based systems have been extensively explored for the development of recombinant vaccines. Herein we describe an innovative vaccinia virus (VACV)-derived vaccine platform technology termed Sementis Copenhagen Vector (SCV), which was rendered multiplication-defective by targeted deletion of the essential viral assembly gene D13L. A SCV cell substrate line was developed for SCV vaccine production by engineering CHO cells to express D13 and the VACV host-range factor CP77, because CHO cells are routinely used for manufacture of biologics...
July 15, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28719194/molecular-modeling-of-the-major-dna-adduct-formed-from-the-food-mutagen-ochratoxin-a-in-nari-2-base-deletion-duplexes-impact-of-sequence-context-and-adduct-ionization-on-conformational-preference-and-mutagenicity
#14
Preetleen Kathuria, Purshotam Sharma, Richard A Manderville, Stacey D Wetmore
Exposure to ochratoxin A (OTA), a possible human carcinogen, leads to many different DNA mutations. As a first step toward understanding the structural basis of OTA-induced mutagenicity, the present work uses a robust computational approach and a slipped mutagenic intermediate model previously studied for C(8)-dG aromatic amine adducts to analyze the conformational features of post-replication 2-base deletion DNA duplexes containing OT-dG, the major OTA lesion at the C(8) position of guanine. Specifically, a total of 960 ns of molecular dynamics simulations (excluding trial simulations) were carried out on four OT-dG ionization states in three sequence contexts within oligomers containing the NarI recognition sequence, a known hotspot for deletion mutations induced by related adducts formed from known carcinogens...
July 18, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28719061/tailored-engineering-of-an-unusual-c4h9nh3-2-ch3nh3-2pb3br10-two-dimensional-multilayered-perovskite-ferroelectric-for-high-performance-photodetectors
#15
Junhua Luo, Lina Li, Zhihua Sun, Peng Wang, Weida Hu, Sasa Wang, Chengmin Ji, Maochun Hong
Two-dimensional (2D) layered hybrid perovskites have shown great potentials in optoelectronics. However, although great efforts have been made, 2D hybrid perovskite ferroelectrics remain rare. Here, we constructed the first ferroelectric with 2D multilayered perovskite framework, (C4H9NH3)2(CH3NH3)2Pb3Br10 (1), by tailored alloying mixed-organic-cations into the prototype of CH3NH3PbBr3. For the first time, concrete ferroelectricity was created by molecular reorientation and synergic ordering of organic cations, which is unprecedented for the known 2D hybrid perovskites...
July 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28717043/tandem-amplification-of-sccmec-can-drive-high-level-methicillin-resistance-in-mrsa
#16
Laura A Gallagher, Simone Coughlan, Nikki S Black, Pierce Lalor, Elaine M Waters, Bryan Wee, Mick Watson, Tim Downing, J Ross Fitzgerald, Gerard T A Fleming, James P O'Gara
Hospital-associated methicillin-resistant Staphylococcus aureus strains typically express high level, homogenous (HoR) β-lactam resistance, whereas community-associated MRSA (CA-MRSA) more commonly express low level heterogeneous (HeR) resistance. Expression of the HoR phenotype typically requires both increased expression of the mecA gene, carried on the Staphylococcus cassette chromosome SCCmec element, and additional mutational event(s) elsewhere on the chromosome. Here the oxacillin concentration in a chemostat culture of the CA-MRSA strain USA300 was increased from 8 μg/ml to 130 μg/ml over 13 days to isolate highly oxacillin resistant derivatives...
July 17, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28709462/enhancing-medical-students-reflectivity-in-mentoring-groups-for-professional-development-a-qualitative-analysis
#17
Gabriele Lutz, Nina Pankoke, Hadass Goldblatt, Marzellus Hofmann, Michaela Zupanic
BACKGROUND: Professional competence is important in delivering high quality patient care, and it can be enhanced by reflection and reflective discourse e.g. in mentoring groups. However, students are often reluctant though to engage in this discourse. A group mentoring program involving all preclinical students as well as faculty members and co-mentoring clinical students was initiated at Witten-Herdecke University. This study explores both the attitudes of those students towards such a program and factors that might hinder or enhance how students engage in reflective discourse...
July 14, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28708234/physicists-views-on-hadrontherapy-a-survey-of-members-of-the-italian-association-of-medical-physics-aifm
#18
Tommaso Giandini, Chiara Tenconi, Mauro Carrara, Mario Ciocca, Stefania Russo, Costanza M V Panaino, Federica Cattani, Delia Ciardo, Sara Morlino, Barbara Avuzzi, Nice Bedini, Sergio Villa, Giulia Marvaso, Paola Romanelli, Azusa Hasegawa, Barbara Vischioni, Francesca Valvo, Barbara A Jereczek-Fossa, Roberto Orecchia, Riccardo Valdagni, Emanuele Pignoli
BACKGROUND: This study was based on a survey to investigate perceptions of hadrontherapy of the members of the Italian Association of Medical Physics (AIFM). The survey was digitally submitted to the 991 members between the end of January and the beginning of April 2016. METHODS: A 19-item questionnaire was designed focusing on advantages and disadvantages of hadrontherapy, current status and possible future improvements, and need and opportunities for future investments in Italy and abroad...
July 8, 2017: Tumori
https://www.readbyqxmd.com/read/28707387/effects-of-nurses-personality-traits-and-their-environmental-characteristics-on-their-workplace-learning-and-nursing-competence
#19
Miyuki Takase, Masako Yamamoto, Yoko Sato
AIM: A good fit between an individual's personality traits and job characteristics motivates employees, and thus enhances their work behavior. However, how nurses' personality traits and their environmental characteristics relate to nurses' engagement in workplace learning, which improves their competence, has not been investigated. The aim of this study was to investigate how nurses' personality traits, environmental characteristics, and workplace learning were related to nursing competence...
July 13, 2017: Japan Journal of Nursing Science: JJNS
https://www.readbyqxmd.com/read/28705788/how-do-clinicians-learn-about-knowledge-translation-an-investigation-of-current-web-based-learning-opportunities
#20
Raechel A Damarell, Jennifer J Tieman
BACKGROUND: Clinicians are important stakeholders in the translation of well-designed research evidence into clinical practice for optimal patient care. However, the application of knowledge translation (KT) theories and processes may present conceptual and practical challenges for clinicians. Online learning platforms are an effective means of delivering KT education, providing an interactive, time-efficient, and affordable alternative to face-to-face education programs. OBJECTIVE: This study investigates the availability and accessibility of online KT learning opportunities for health professionals...
July 13, 2017: JMIR Medical Education
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