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https://www.readbyqxmd.com/read/27914303/a-necessary-evil-residential-placement-of-people-with-intellectual-disability-among-the-palestinian-minority-in-israel
#1
Kareem Nasser, Dalia Sachs, Amalia Sa'ar
Among the Palestinian minority in Israel, residential placement of people with intellectual disabilities [ID] is relatively new and steadily increasing, but poorly studied. A qualitative design was used to explore the process of residential placement decision by 18 parents of people with ID through semi-structured interviews. Sampling was purposive and data was analyzed thematically. Four main themes emerged representing parents' perceptions and experiences along the placement decision-making process, together indicating an experience of deeply 'conflicted parenting': (a) initial resistance to placement and its perception as abandonment and parental failure; (b) attrition following cumulative difficulties and lack of assistance; (c) resignation and reframing of placement as a necessary evil; (d) relief mixed with guilt, pain, and ambivalence following placement...
November 30, 2016: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/27914063/episweep-computationally-driven-reengineering-of-therapeutic-proteins-to-reduce-immunogenicity-while-maintaining-function
#2
Yoonjoo Choi, Deeptak Verma, Karl E Griswold, Chris Bailey-Kellogg
Therapeutic proteins are yielding ever more advanced and efficacious new drugs, but the biological origins of these highly effective therapeutics render them subject to immune surveillance within the patient's body. When recognized by the immune system as a foreign agent, protein drugs elicit a coordinated response that can manifest a range of clinical complications including rapid drug clearance, loss of functionality and efficacy, delayed infusion-like allergic reactions, more serious anaphylactic shock, and even induced auto-immunity...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27908389/hypertension-obesity-diabetes-and%C3%A2-heart%C3%A2-failure-free-survival-the-cardiovascular-disease-lifetime-risk-pooling-project
#3
Faraz S Ahmad, Hongyan Ning, Jonathan D Rich, Clyde W Yancy, Donald M Lloyd-Jones, John T Wilkins
OBJECTIVES: This study was designed to quantify the relationship between the absence of heart failure risk factors in middle age and incident heart failure, heart failure-free survival, and overall survival. BACKGROUND: Quantification of years lived free from heart failure in the context of risk factor burden in mid-life may improve risk communication and prevention efforts. METHODS: We conducted a pooled, individual-level analysis sampling from communities across the United States as part of 4 cohort studies: the Framingham Heart, Framingham Offspring, Chicago Heart Association Detection Project in Industry, and ARIC (Atherosclerosis Risk In Communities) studies...
December 2016: JACC. Heart Failure
https://www.readbyqxmd.com/read/27907985/effectiveness-of-training-intervention-to-improve-medical-student-s-information-literacy-skills
#4
Mohammadhiwa Abdekhoda, Afsaneh Dehnad, Mahmood Yousefi
This study aimed to assess the efficiency of delivering a 4-month course of "effective literature search" among medical postgraduate students for improving information literacy skills. This was a cross-sectional study in which 90 postgraduate students were randomly selected and participated in 12 training sessions. Effective search strategies were presented and the students' attitude and competency concerning online search were measured by a pre- and post-questionnaires and skill tests. Data were analyzed by SPSS version 16 using t-test...
December 2016: Korean Journal of Medical Education
https://www.readbyqxmd.com/read/27907980/flipped-clinical-training-a-structured-training-method-for-undergraduates-in-complete-denture-prosthesis
#5
Anbarasi K, Kasim Mohamed K, Phagalvarthy Vijayaraghavan, Deivanayagam Kandaswamy
PURPOSE: To design and implement flipped clinical training for undergraduate dental students in removable complete denture treatment and predict its effectiveness by comparing the assessment results of students trained by flipped and traditional methods. METHODS: Flipped training was designed by shifting the learning from clinics to learning center (phase I) and by preserving the practice in clinics (phase II). In phase I, student-faculty interactive session was arranged to recap prior knowledge...
December 2016: Korean Journal of Medical Education
https://www.readbyqxmd.com/read/27907189/structural-insights-into-streptococcal-competence-regulation-by-the-cell-to-cell-communication-system-comrs
#6
Antoine Talagas, Laetitia Fontaine, Laura Ledesma-Garca, Johann Mignolet, Inès Li de la Sierra-Gallay, Noureddine Lazar, Magali Aumont-Nicaise, Michael J Federle, Gerd Prehna, Pascal Hols, Sylvie Nessler
In Gram-positive bacteria, cell-to-cell communication mainly relies on extracellular signaling peptides, which elicit a response either indirectly, by triggering a two-component phosphorelay, or directly, by binding to cytoplasmic effectors. The latter comprise the RNPP family (Rgg and original regulators Rap, NprR, PrgX and PlcR), whose members regulate important bacterial processes such as sporulation, conjugation, and virulence. RNPP proteins are increasingly considered as interesting targets for the development of new antibacterial agents...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27906158/singing-for-lung-health-a-systematic-review-of-the-literature-and-consensus-statement
#7
REVIEW
Adam Lewis, Phoene Cave, Myra Stern, Lindsay Welch, Karen Taylor, Juliet Russell, Anne-Marie Doyle, Anne-Marie Russell, Heather McKee, Stephen Clift, Julia Bott, Nicholas S Hopkinson
There is growing interest in Singing for Lung Health (SLH), an approach where patients with respiratory disease take part in singing groups, intended to improve their condition. A consensus group was convened in early 2016 to address issues including: the specific features that make SLH distinct from other forms of participation in singing; the existing evidence base via a systematic review; gaps in the evidence base including the need to define value-based outcome measures for sustainable commissioning of SLH; defining the measures needed to evaluate both individuals' responses to SLH and the quality of singing programmes...
December 1, 2016: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/27905524/insights-into-the-competing-mechanisms-and-origin-of-enantioselectivity-for-n-heterocyclic-carbene-catalyzed-reaction-of-aldehyde-with-enamide
#8
Yan Qiao, Xinhuan Chen, Donghui Wei, Junbiao Chang
Hydroacylation reactions and aza-benzoin reactions have attracted considerable attention from experimental chemists. Recently, Wang et al. reported an interesting reaction of N-heterocyclic carbene (NHC)-catalyzed addition of aldehyde to enamide, in which both hydroacylation and aza-benzoin reactions may be involved. Thus, understanding the competing relationship between them is of great interest. Now, density functional theory (DFT) investigation was performed to elucidate this issue. Our results reveal that enamide can tautomerize to its imine isomer with the assistance of HCO3(-)...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27900182/concussion-reporting-behaviours-of-community-college-student-athletes-and-limits-of-transferring-concussion-knowledge-during-the-stress-of-competition
#9
Nancy Resendes Chinn, Paul Porter
: Concussion education for student-athletes is mandated by several states and is becoming an integral component of concussion management programmes; however, little is known about student-athlete concussion knowledge and self-reporting of suspected concussion. This study explored to what extent collegiate student-athletes are knowledgeable on the topic of concussion, the relationship between having concussion knowledge and reporting behaviours, and factors contributing to not reporting when education has been provided...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27896692/teaching-structure-a-qualitative-evaluation-of-a-structural-competency-training-for-resident-physicians
#10
Joshua Neff, Kelly R Knight, Shannon Satterwhite, Nick Nelson, Jenifer Matthews, Seth M Holmes
BACKGROUND: The influence of societal inequities on health has long been established, but such content has been incorporated unevenly into medical education and clinical training. Structural competency calls for medical education to highlight the important influence of social, political, and economic factors on health outcomes. AIM: This article describes the development, implementation, and evaluation of a structural competency training for medical residents. SETTING: A California family medicine residency program serving a patient population predominantly (88 %) with income below 200 % of the federal poverty level...
November 28, 2016: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/27895255/flue-gas-and-direct-air-capture-of-co2-by-porous-metal-organic-materials
#11
David G Madden, Hayley S Scott, Amrit Kumar, Kai-Jie Chen, Rana Sanii, Alankriti Bajpai, Matteo Lusi, Teresa Curtin, John J Perry, Michael J Zaworotko
Sequestration of CO2, either from gas mixtures or directly from air (direct air capture), is a technological goal important to large-scale industrial processes such as gas purification and the mitigation of carbon emissions. Previously, we investigated five porous materials, three porous metal-organic materials (MOMs), a benchmark inorganic material, ZEOLITE 13X: and a chemisorbent, TEPA-SBA-15: , for their ability to adsorb CO2 directly from air and from simulated flue-gas. In this contribution, a further 10 physisorbent materials that exhibit strong interactions with CO2 have been evaluated by temperature-programmed desorption for their potential utility in carbon capture applications: four hybrid ultramicroporous materials, SIFSIX-3-CU: , DICRO-3-NI-I: , SIFSIX-2-CU-I: and MOOFOUR-1-NI: ; five microporous MOMs, DMOF-1: , ZIF-8: , MIL-101: , UIO-66: and UIO-66-NH2: ; an ultramicroporous MOM, NI-4-PYC: The performance of these MOMs was found to be negatively impacted by moisture...
January 13, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/27892421/screening-for-atrial-fibrillation-during-influenza-vaccinations-by-primary-care-nurses-using-a-smartphone-electrocardiograph-iecg-a-feasibility-study
#12
Jessica Orchard, Nicole Lowres, S Ben Freedman, Laila Ladak, William Lee, Nicholas Zwar, David Peiris, Yasith Kamaladasa, Jialin Li, Lis Neubeck
BACKGROUND: People with unknown atrial fibrillation (AF), who are often asymptomatic, have a substantially increased risk of stroke. Although recommended in European guidelines, AF screening is not routinely performed. Screening at the time of influenza vaccination presents an ideal opportunity to detect AF in large numbers in a primary care medical setting, with an existing annual recall system for patients aged ≥65 years. DESIGN: Cross-sectional pilot study of handheld smartphone electrocardiogram (iECG) screening to identify unknown AF...
October 2016: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/27890048/cultural-hegemony-educators-perspectives-on-facilitating-cross-cultural-dialogue
#13
Zareen Zaidi, Daniëlle Verstegen, Rashmi Vyas, Omayma Hamed, Tim Dornan, Page Morahan
BACKGROUND: We live in an age when education is being internationalized. This can confront students with 'cultural hegemony' that can result from the unequal distribution of power and privilege in global society. The name that is given to awareness of social inequality is 'critical consciousness'. Cross-cultural dialogue provides an opportunity for learners to develop critical consciousness to counter cultural hegemony. The purpose of this research was to understand how learners engage with cross-cultural dialogue, so we can help them do so more effectively in the future...
2016: Medical Education Online
https://www.readbyqxmd.com/read/27889691/development-of-a-culturally-competent-service-to-improve-academic-functioning-for-latino-survivors-of-acute-lymphoblastic-leukemia-methodological-considerations
#14
Laura Bava, Alexis Johns, David R Freyer, Kathleen Ruccione
Many survivors of childhood acute lymphoblastic leukemia (ALL) develop neurocognitive deficits that compromise academic functioning, especially in the presence of sociodemographic risk factors. The extent to which these risk factors coexist for Latino ALL survivors is not well described, but with shifts in U.S. demographics and improved survival in ALL, culturally competent interventions are needed. The Achieving Best Cognitive Successes after Cancer service was designed and implemented by a team representing nursing, medicine, psychology, and social work...
November 25, 2016: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
https://www.readbyqxmd.com/read/27888945/radiology-as-the-point-of-cancer-patient-and-care%C3%A2-team-engagement-applying-the-4r-model-at%C3%A2-a-patient-s-breast-cancer-care-initiation
#15
Christine B Weldon, Sarah M Friedewald, Swati A Kulkarni, Melissa A Simon, Ruth C Carlos, Jonathan B Strauss, Mikele M Bunce, Art Small, Julia R Trosman
Radiologists aspire to improve patient experience and engagement, as part of the Triple Aim of health reform. Patient engagement requires active partnerships among health providers and patients, and rigorous teamwork provides a mechanism for this. Patient and care team engagement are crucial at the time of cancer diagnosis and care initiation but are complicated by the necessity to orchestrate many interdependent consultations and care events in a short time. Radiology often serves as the patient entry point into the cancer care system, especially for breast cancer...
December 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27888784/the-influence-of-a-preceptor-student-daily-feedback-tool-on-clinical-feedback-practices-in-nursing-education-a-qualitative-study
#16
Louise Allen, Elizabeth Molloy
BACKGROUND: Feedback in clinical education is essential for the development of competent nurses. When the process is enacted well, it offers measured performance against standards required by the nursing health profession, promoting learning and behavioural change. Despite this, health literature describes numerous barriers to effective feedback processes. OBJECTIVE: A qualitative descriptive design was used to determine whether the introduction of a Daily Feedback Tool addressing some of the barriers to effective feedback, influenced nursing students and clinical supervisors (preceptors) experiences in nursing clinical education...
November 19, 2016: Nurse Education Today
https://www.readbyqxmd.com/read/27884729/rationale-and-design-of-the-coronary-artery-calcium-consortium-a-multicenter-cohort-study
#17
Michael J Blaha, Seamus P Whelton, Mahmoud Al Rifai, Zeina A Dardari, Leslee J Shaw, Mouaz H Al-Mallah, Kuni Matsushita, John A Rumberger, Daniel S Berman, Matthew J Budoff, Michael D Miedema, Khurram Nasir
BACKGROUND: Although coronary artery calcium (CAC) has been investigated for over two decades, there is very limited data on the association of CAC with cause of death. The CAC Consortium is a large ongoing multi-center observational cohort of individuals who underwent non-contrast cardiac-gated CAC testing and systematic, prospective, long-term follow-up for mortality with ascertainment of cause of death. METHODS: Four participating institutions from three states within the US (California, Minnesota, and Ohio) have contributed individual-level patient data to the CAC Consortium (spanning years 1991-2010)...
November 11, 2016: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/27882063/design-construction-and-evaluation-of-1a-jfh1-hcv-chimera-by-replacing-the-intergenotypic-variable-region
#18
Faezeh Ghasemi, Majid Ghayour-Mobarhan, Alireza Pasdar, Hamid Pourianfar, Mohammad Reza Aghasadeghi, Hamed Gouklani, Zahra Meshkat
BACKGROUND: The E2 glycoprotein is an important encoded hepatitis C virus (HCV) protein that contains three different variable regions. OBJECTIVES: The aim of the present study was to construct an HCV 1a/JFH1 chimeric virus by replacing the intergenotypic variable region (igVR) fragment of the highly variable region of the E2 gene of the Japanese Fulminant hepatitis genotype 2a JFH1 virus with a similar region of HCV genotype 1a. This chimera was produced as a model virus with the ability to be cultured...
October 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27882040/a-new-model-of-master-of-philosophy-in-physiological-sciences
#19
H R Ahmad, F M Arain, N A Khan
The objectives of Master of Philosophy (MPhil) in Physiological Sciences are: 1) to describe the new ways in which anatomy, biochemistry and physiology on one hand, and microbiology, pathology and pharmacology on other hand meet their functional requirements through multidisciplinary integrated concepts; 2) to elucidate relationships between cell biology, molecular biology and molecular genetics by connecting dots of how cell functions are driven by molecules and being controlled by genes. This forms the basis of cell, molecular and genetics [CMG] module upon which 7 multidisciplinary modules of Physiological Sciences follow; 3) these 24 credit hours provide the physiological basis for PhD studies as well as faculty development to enhance learning abilities of medical student; 4) the modules constitute Cardio- Respiratory Physiological Sciences, GI and Renal Physiological Sciences, Neurosciences, Endo-Reproductive Physiological Sciences...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27881684/conformational-flexibility-of-an-anti-il-13-darpin%C3%A2
#20
Alexey Teplyakov, Thomas J Malia, Galina Obmolova, Steven A Jacobs, Karyn T O'Neil, Gary L Gilliland
Designed ankyrin repeat proteins (DARPin(®)) are artificial non-immunoglobulin binding proteins with potential applications as therapeutic molecules. DARPin 6G9 binds interleukin-13 with high affinity and blocks the signaling pathway and as such is promising for the treatment of asthma and other atopic diseases. The crystal structures of DARPin 6G9 in the unbound form and in complex with IL-13 were determined at high resolution. The DARPin competes for the same epitope as the IL-13 receptor chain 13Rα1 but does not interfere with the binding of the other receptor chain, IL-4Rα...
November 23, 2016: Protein Engineering, Design & Selection: PEDS
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