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https://www.readbyqxmd.com/read/28077912/emptyheaded-a-relational-engine-for-graph-processing
#1
Christopher R Aberger, Susan Tu, Kunle Olukotun, Christopher Ré
There are two types of high-performance graph processing engines: low- and high-level engines. Low-level engines (Galois, PowerGraph, Snap) provide optimized data structures and computation models but require users to write low-level imperative code, hence ensuring that efficiency is the burden of the user. In high-level engines, users write in query languages like datalog (SociaLite) or SQL (Grail). High-level engines are easier to use but are orders of magnitude slower than the low-level graph engines. We present EmptyHeaded, a high-level engine that supports a rich datalog-like query language and achieves performance comparable to that of low-level engines...
June 2016: Proceedings
https://www.readbyqxmd.com/read/28077834/-validity-and-reliability-of-korean-version-of-the-spiritual-care-competence-scale
#2
Mi Ja Chung, Youngrye Park, Young Eun
PURPOSE: The aim of this study was to examine the validity and reliability of the Korean Version of the Spiritual Care Competence Scale (K-SCCS). METHODS: A cross-sectional study design was used. The K-SCCS consisted of 26 questions to measure spiritual care competence of nurses. Participants, 228 nurses who had more than 3 years'experience as a nurse, completed the survey. Confirmatory factor analysis was used to examine the construct validity and correlations of K-SCCS and spiritual well-being (SWB) were used to examine the criterion validity of K-SCCS...
December 2016: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/28077246/testing-of-a-palatable-bait-and-compatible-vaccine-carrier-for-the-oral-vaccination-of-european-badgers-meles-meles-against-tuberculosis
#3
Sonya Gowtage, Gareth A Williams, Ray Henderson, Paul Aylett, Duncan MacMorran, Si Palmer, Andy Robertson, Sandrine Lesellier, Stephen P Carter, Mark A Chambers
The oral vaccination of wild badgers (Meles meles) with live Bacillus Calmette-Guérin (BCG) is one of the tools being considered for the control of bovine tuberculosis (caused by Mycobacterium bovis) in the UK. The design of a product for oral vaccination requires that numerous, and often competing, conditions are met. These include the need for a highly palatable, but physically stable bait that will meet regulatory requirements, and one which is also compatible with the vaccine formulation; in this case live BCG...
January 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28073972/awareness-and-attitude-regarding-reproductive-options-of-persons-carrying-a-brca-mutation-and-their-partners
#4
J J G Gietel-Habets, C E M de Die-Smulders, I A P Derks-Smeets, A Tibben, V C G Tjan-Heijnen, R van Golde, E Gomez-Garcia, C M Kets, L A D M van Osch
STUDY QUESTION: To what extent are BRCA mutation carriers and their partners in the Netherlands aware about preimplantation genetic diagnosis (PGD) and prenatal diagnosis (PND) as reproductive options and what is their attitude towards these options? SUMMARY ANSWER: Awareness of PGD (66%) and PND (61%) among BRCA mutation carriers and their partners is relatively high and 80% and 26%, respectively, of BRCA carriers and their partners find offering PGD and PND for hereditary breast and ovarian cancer (HBOC) acceptable...
January 9, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28069016/short-and-long-term-effectiveness-of-a-three-month-individualized-need-supportive-physical-activity-counseling-intervention-at-the-workplace
#5
Anass Arrogi, Astrid Schotte, An Bogaerts, Filip Boen, Jan Seghers
BACKGROUND: The objective of the present study was to evaluate the short- and long-term intervention and mediation effects of a 3-month individualized need-supportive physical activity (PA) counseling intervention on employees' PA and sedentary behavior. METHODS: Insufficiently active employees (n = 300; mean age 42 ± 9 years; 78% female) were recruited from a large pharmaceutical company in Flanders, Belgium. A quasi-experimental design was used in which the intervention group (N = 246) was recruited separately from the reference group (N = 54)...
January 9, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28068981/factors-affecting-evidence-use-in-food-policy-making-processes-in-health-and-agriculture-in-fiji
#6
Gade Waqa, Colin Bell, Wendy Snowdon, Marj Moodie
BACKGROUND: There is limited research on the use of evidence to inform policy-making in the Pacific. This study aims to identify and describe factors that facilitate or limit the use of evidence in food-related policy-making in the Health and Agriculture Ministries in Fiji. METHODS: Semi-structured face-to-face interviews were conducted with selected policy-makers in two government ministries that were instrumental in the development of food-related policies in Fiji designed to prevent Non-Communicable Diseases (NCDs)...
January 9, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28065344/abai-s-moc-assessment-of-knowledge-program-matures-adding-value-with-continuous-learning-and-assessment
#7
REVIEW
David I Bernstein, Stephen I Wasserman, William P Thompson, Theodore M Freeman
Rapid changes in modern medicine along with advances in the science of learning and memory have necessitated a shift in the way physician knowledge is assessed. Physician recertification beyond initial certification has historically consisted of retaining large amounts of knowledge over a long time span. The adult learning theory has shown that the maintenance and improvement of our knowledge base is more effective by being exposed to new concepts at regular intervals throughout one's career and reinforcing these concepts on an ongoing basis...
January 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28063303/peptides-and-peptidomimetics-as-regulators-of-protein-protein-interactions
#8
REVIEW
Anna D Cunningham, Nir Qvit, Daria Mochly-Rosen
Protein-protein interactions are essential for almost all intracellular and extracellular biological processes. Regulation of protein-protein interactions is one strategy to regulate cell fate in a highly selective manner. Specifically, peptides are ideal candidates for inhibition of protein-protein interactions because they can mimic a protein surface to effectively compete for binding. Additionally, peptides are synthetically accessible and can be stabilized by chemical modifications. In this review, we survey screening and rational design methods for identifying peptides to inhibit protein-protein interactions, as well as methods for stabilizing peptides to effectively mimic protein surfaces...
January 4, 2017: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/28060885/antibodies-targeting-closely-adjacent-or-minimally-overlapping-epitopes-can-displace-one-another
#9
Yasmina Noubia Abdiche, Andy Yik Yeung, Irene Ni, Donna Stone, Adam Miles, Winse Morishige, Andrea Rossi, Pavel Strop
Here we describe how real-time label-free biosensors can be used to identify antibodies that compete for closely adjacent or minimally overlapping epitopes on their specific antigen via a mechanism of antibody displacement. By kinetically perturbing one another's binding towards their antigen via the formation of a transient trimolecular complex, antibodies can displace one another in a fully reversible and dose-dependent manner. Displacements can be readily identified when epitope binning assays are performed in a classical sandwich assay format whereby a solution antibody (analyte) is tested for binding to its antigen that is first captured via an immobilized antibody (ligand) because an inverted sandwiching response is observed when an analyte displaces a ligand, signifying the antigen's unusually rapid dissociation from its ligand...
2017: PloS One
https://www.readbyqxmd.com/read/28060704/segnet-a-deep-convolutional-encoder-decoder-architecture-for-scene-segmentation
#10
Vijay Badrinarayanan, Alex Kendall, Roberto Cipolla
We present a novel and practical deep fully convolutional neural network architecture for semantic pixel-wise segmentation termed SegNet. This core trainable segmentation engine consists of an encoder network, a corresponding decoder network followed by a pixel-wise classification layer. The architecture of the encoder network is topologically identical to the 13 convolutional layers in the VGG16 network [1]. The role of the decoder network is to map the low resolution encoder feature maps to full input resolution feature maps for pixel-wise classification...
January 2, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28059905/functional-tricuspid-regurgitation-model-in-a-beating-heart-platform
#11
Michal Jaworek, Marco Piola, Federico Lucherini, Guido Gelpi, Marco Castagna, Giuliana Lentini, Carlo Antona, Gianfranco B Fiore, Riccardo Vismara
Currently, clinicians are seeking new, minimally invasive treatment options for functional tricuspid regurgitation (FTR). Challenging tricuspid complexity requires the evaluation of the treatment techniques in adequate and realistic preclinical scenario. The purpose of this paper is to describe the design and functional assessment of a novel passive beating heart model of the pulmonary circulation with the possibility to tightly control FTR.The model housed porcine hearts actuated by a volumetric pump that cyclically pressurized the right ventricle...
January 3, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28059834/what-do-we-know-about-intraoperative-teaching-a-systematic-review
#12
Matthew D Timberlake, Helen G Mayo, Lauren Scott, Joshua Weis, Aimee K Gardner
BACKGROUND: There is increasing attention on enhancing surgical trainee performance and competency. The purpose of this review is to identify characteristics and themes related to intraoperative teaching that will better inform interventions and assessment endeavors. METHODS: A systematic search was carried out of the Ovid MEDLINE, Ovid MEDLINE InProcess, Ovid Embase, and the Cochrane Library databases to identify all studies that discussed teaching in the operating room for trainees at the resident and fellow level...
January 3, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28057874/pregnancy-and-live-birth-rates-after-microsurgical-vasoepididymostomy-for-azoospermic-patients-with-epididymal-obstruction
#13
Jing Peng, Zhichao Zhang, Yiming Yuan, Wanshou Cui, Weidong Song
STUDY QUESTION: Can microsurgical vasoepididymostomy (MVE) be an effective treatment for azoospermic men with epididymal obstruction? SUMMARY ANSWER: MVE is an effective treatment for epididymal obstruction, with overall patency and live birth rates of 76.3% and 34.8%, respectively. WHAT IS KNOWN ALREADY: We showed that MVE was an effective treatment for non-vasectomized patients with epididymal obstruction and prior failed sperm retrieval for ICSI...
January 5, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28051857/broad-spectrum-kinase-profiling-in-live-cells-with-lysine-targeted-sulfonyl-fluoride-probes
#14
Qian Zhao, Xiaohu Ouyang, Xiaobo Wan, Ketan S Gajiwala, John C Kath, Lyn H Jones, Alma L Burlingame, Jack Taunton
Protein kinases comprise a large family of structurally related enzymes. A major goal in kinase-inhibitor development is to selectively engage the desired kinase while avoiding myriad off-target kinases. However, quantifying inhibitor interactions with multiple endogenous kinases in live cells remains an unmet challenge. Here, we report the design of sulfonyl fluoride probes that covalently label a broad swath of the intracellular kinome with high efficiency. Protein crystallography and mass spectrometry confirmed a chemoselective reaction between the sulfonyl fluoride and a conserved lysine in the ATP binding site...
January 4, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28051331/nurses-attitudes-toward-family-importance-in-heart-failure-care
#15
Annelie K Gusdal, Karin Josefsson, Eva Thors Adolfsson, Lene Martin
BACKGROUND: Support from the family positively affects self-management, patient outcomes and the incidence of hospitalizations among patients with heart failure. To involve family members in heart failure care is thus valuable for the patients. Registered nurses frequently meet family members of patients with heart failure and the quality of these encounters is likely to be influenced by the attitudes registered nurses hold toward families. AIMS: To explore registered nurses' attitudes toward the importance of families' involvement in heart failure nursing care and to identify factors that predict the most supportive attitudes...
January 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28050222/validity-reliability-and-acceptability-of-the-team-standardized-assessment-of-clinical-encounter-report
#16
Camilla L Wong, Mireille Norris, Samir S Sinha, Maria L Zorzitto, Sushma Madala, Jemila S Hamid
BACKGROUND: The Team Standardized Assessment of a Clinical Encounter Report (StACER) was designed for use in Geriatric Medicine residency programs to evaluate Communicator and Collaborator competencies. METHODS: The Team StACER was completed by two geriatricians and interdisciplinary team members based on observations during a geriatric medicine team meeting. Postgraduate trainees were recruited from July 2010-November 2013. Inter-rater reliability between two geriatricians and between all team members was determined...
December 2016: Canadian Geriatrics Journal: CGJ
https://www.readbyqxmd.com/read/28048615/tu-h-202-04-the-vampire-challenge-preliminary-results-from-a-multi-institutional-study-of-ct-ventilation-image-accuracy
#17
J Kipritidis
: CT ventilation imaging is an exciting functional imaging modality that combines four-dimensional computed tomography (4DCT) and deformable image registration (DIR) to provide exquisite ventilation maps of the lung. CT ventilation imaging can be used for: (1) Functional avoidance in thoracic radiation therapy, (2) Imaging longitudinal changes in regional lung function for treatment assessment and adaptation, (3) Image-assisted diagnosis of non-oncologic respiratory diseases. CT ventilation imaging uses CT, a predominantly anatomic imaging modality, and through imaging processing creates functional images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048557/tu-h-202-00-ct-ventilation-imaging-the-new-clinical-reality-of-functional-avoidance-and-response-assessment-in-lung-cancer-radiation-therapy
#18
Paul Keall
: CT ventilation imaging is an exciting functional imaging modality that combines four-dimensional computed tomography (4DCT) and deformable image registration (DIR) to provide exquisite ventilation maps of the lung. CT ventilation imaging can be used for: (1) Functional avoidance in thoracic radiation therapy, (2) Imaging longitudinal changes in regional lung function for treatment assessment and adaptation, (3) Image-assisted diagnosis of non-oncologic respiratory diseases. CT ventilation imaging uses CT, a predominantly anatomic imaging modality, and through imaging processing creates functional images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047895/tu-h-202-01-introduction-to-ct-ventilation-imaging-principles-validation-and-clinical-translation
#19
T Yamamoto
: CT ventilation imaging is an exciting functional imaging modality that combines four-dimensional computed tomography (4DCT) and deformable image registration (DIR) to provide exquisite ventilation maps of the lung. CT ventilation imaging can be used for: (1) Functional avoidance in thoracic radiation therapy, (2) Imaging longitudinal changes in regional lung function for treatment assessment and adaptation, (3) Image-assisted diagnosis of non-oncologic respiratory diseases. CT ventilation imaging uses CT, a predominantly anatomic imaging modality, and through imaging processing creates functional images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047233/tu-h-202-02-applications-validation-clinical-endpoints-and-opportunities-for-ct-ventilation
#20
Y Vinogradskiy
: CT ventilation imaging is an exciting functional imaging modality that combines four-dimensional computed tomography (4DCT) and deformable image registration (DIR) to provide exquisite ventilation maps of the lung. CT ventilation imaging can be used for: (1) Functional avoidance in thoracic radiation therapy, (2) Imaging longitudinal changes in regional lung function for treatment assessment and adaptation, (3) Image-assisted diagnosis of non-oncologic respiratory diseases. CT ventilation imaging uses CT, a predominantly anatomic imaging modality, and through imaging processing creates functional images...
June 2016: Medical Physics
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