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https://www.readbyqxmd.com/read/28802638/spiritual-perspectives-of-emergency-medicine-doctors-and-nurses-in-caring-for-end-of-life-patients-a-mixed-method-study
#1
Yingting Zhang, Rakhee Yash Pal, Wai San Wilson Tam, Alice Lee, Mabel Ong, Lay Hwa Tiew
BACKGROUND: End-of-life care is becoming more prevalent in the Emergency Department. Quality end-of-life care includes spiritual support. As spirituality is a relatively vague concept, understanding healthcare professionals' spiritual perspectives is important. AIMS: To explore the perspectives of Emergency Department doctors and nurses in (i) spirituality, (ii) spiritual care domain in end-of-life care and (iii) factors influencing spiritual care provision in the Emergency Department...
August 9, 2017: International Emergency Nursing
https://www.readbyqxmd.com/read/28801760/the-need-for-authenticity-based-autonomy-in-medical-ethics
#2
Lucie White
The notion of respect for autonomy dominates bioethical discussion, though what qualifies precisely as autonomous action is notoriously elusive. In recent decades, the notion of autonomy in medical contexts has often been defined in opposition to the notion of autonomy favoured by theoretical philosophers. Where many contemporary theoretical accounts of autonomy place emphasis on a condition of "authenticity", the special relation a desire must have to the self, bioethicists often regard such a focus as irrelevant to the concerns of medical ethics, and too stringent for use in practical contexts...
August 11, 2017: HEC Forum: An Interdisciplinary Journal on Hospitals' Ethical and Legal Issues
https://www.readbyqxmd.com/read/28799961/nurses-perceptions-of-psychosocial-care-and-barriers-to-its-provision-a-qualitative-study
#3
Cassandra Siyun Chen, Sally Wai-Chi Chan, Moon Fai Chan, Suk Foon Yap, Wenru Wang, Yanika Kowitlawakul
BACKGROUND: Psychosocial care is the culturally sensitive provision of psychological, social, and spiritual care through therapeutic communication. Current evidence suggests that effective psychosocial care improves patients' health outcomes and quality of life. PURPOSE: The aim of this study was to explore nurses' perceptions and experiences in providing psychosocial care to patients and to identify the related barriers and challenges. METHODS: An exploratory qualitative design using semistructured, individual, face-to-face interviews was adopted...
August 10, 2017: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/28799849/public-health-activist-skills-pyramid-a-model-for-implementing-health-in-all-policies
#4
Behzad Damari, Elham Ehsani Chimeh
Affecting public health for society requires various competencies. In fact, the prerequisite for the implementation of health in all policies should be effectiveness of public health activists (PHAs) in these competencies. This study aims to determine the competencies of the activists in public health. The present qualitative study reviewed the literature and adopted qualitative methods like content analysis, stakeholder interviews, and conducted focus group discussions with related experts. In each stage, the required competencies were extracted through drawing the main action processes of a PHA...
August 11, 2017: Social Work in Public Health
https://www.readbyqxmd.com/read/28798737/complete-genome-analysis-of-thermus-parvatiensis-and-comparative-genomics-of-thermus-spp-provide-insights-into-genetic-variability-and-evolution-of-natural-competence-as-strategic-survival-attributes
#5
Charu Tripathi, Harshita Mishra, Himani Khurana, Vatsala Dwivedi, Komal Kamra, Ram K Negi, Rup Lal
Thermophilic environments represent an interesting niche. Among thermophiles, the genus Thermus is among the most studied genera. In this study, we have sequenced the genome of Thermus parvatiensis strain RL, a thermophile isolated from Himalayan hot water springs (temperature >96°C) using PacBio RSII SMRT technique. The small genome (2.01 Mbp) comprises a chromosome (1.87 Mbp) and a plasmid (143 Kbp), designated in this study as pTP143. Annotation revealed a high number of repair genes, a squeezed genome but containing highly plastic plasmid with transposases, integrases, mobile elements and hypothetical proteins (44%)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28798225/ethical-issues-in-alzheimer-s-disease-research-involving-human-subjects
#6
Dena S Davis
As we aggressively pursue research to cure and prevent Alzheimer's disease, we encounter important ethical challenges. None of these challenges, if handled thoughtfully, would pose insurmountable barriers to research. But if they are ignored, they could slow the research process, alienate potential study subjects and do damage to research recruits and others. These challenges are (1) the necessity of very large cohorts of research subjects, recruited for lengthy studies, probably ending only in the subjects' death; (2) the creation of cohorts of 'study ready' volunteers, many of whom will be competent to consent at the beginning of the process, but move into cognitive impairment later; (3) reliance on adaptive trial design, creating challenges for informed consent, equipoise and justice; (4) the use of biomarkers and predictive tests that describe risk rather than certainty, and that can threaten participants' welfare if the information is obtained by insurance companies or long-term care providers; (5) the use of study partners that creates unique risks of harm to the relationship of subject and study partner...
August 10, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28796434/a-comparison-of-regression-methods-for-model-selection-in-individual-based-landscape-genetic-analysis
#7
A J Shirk, E L Landguth, S A Cushman
Anthropogenic migration barriers fragment many populations and limit the ability of species to respond to climate-induced biome shifts. Conservation actions designed to conserve habitat connectivity and mitigate barriers are needed to unite fragmented populations into larger, more viable metapopulations, and to allow species to track their climate envelope over time. Landscape genetic analysis provides an empirical means to infer landscape factors influencing gene flow, and thereby inform such conservation actions...
August 10, 2017: Molecular Ecology Resources
https://www.readbyqxmd.com/read/28796433/understanding-emergency-care-delivery-through-computer-simulation-modeling
#8
Lauren F Laker, Elham Torabi, Daniel J France, Craig M Froehle, Eric J Goldlust, Nathan R Hoot, Parastu Kasaie, Michael S Lyons, Laura H Barg-Walkow, Michael J Ward, Robert L Wears
In 2017, Academic Emergency Medicine convened a consensus conference entitled, "Catalyzing System Change through Health Care Simulation: Systems, Competency, and Outcomes." This manuscript, a product of the breakout session on "understanding complex interactions through systems modeling," explores the role that computer simulation modeling can and should play in research and development of emergency care delivery systems. This manuscript discusses areas central to the use of computer simulation modeling in emergency care research...
August 10, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28794475/dynamic-mechano-regulation-of-myoblast-cells-on-supramolecular-hydrogels-cross-linked-by-reversible-host-guest-interactions
#9
Marcel Hörning, Masaki Nakahata, Philip Linke, Akihisa Yamamoto, Mariam Veschgini, Stefan Kaufmann, Yoshinori Takashima, Akira Harada, Motomu Tanaka
A new class of supramolecular hydrogels, cross-linked by host-guest interactions between β-cyclodextrin (βCD) and adamantane, were designed for the dynamic regulation of cell-substrate interactions. The initial substrate elasticity can be optimized by selecting the molar fraction of host- and guest monomers for the target cells. Moreover, owing to the reversible nature of host-guest interactions, the magnitude of softening and stiffening of the substrate can be modulated by varying the concentrations of free, competing host molecules (βCD) in solutions...
August 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28794215/male-relatedness-and-familiarity-are-required-to-modulate-male-induced-harm-to-females-in-drosophila
#10
Sally Le Page, Irem Sepil, Ewan Flintham, Tommaso Pizzari, Pau Carazo, Stuart Wigby
Males compete over mating and fertilization, and often harm females in the process. Inclusive fitness theory predicts that increasing relatedness within groups of males may relax competition and discourage male harm of females as males gain indirect benefits. Recent studies in Drosophila melanogaster are consistent with these predictions, and have found that within-group male relatedness increases female fitness, though others have found no effects. Importantly, these studies did not fully disentangle male genetic relatedness from larval familiarity, so the extent to which modulation of harm to females is explained by male familiarity remains unclear...
August 16, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28792760/structural-basis-of-wee-kinases-functionality-and-inactivation-by-diverse-small-molecule-inhibitors
#11
Jin-Yi Zhu, Rebecca Ann Duenes Cuellar, Norbert Berndt, Hee Eun Lee, Sanne H Olesen, Mathew P Martin, Jeffrey T Jensen, Gunda I Georg, Ernst Schönbrunn
Members of the Wee family of kinases negatively regulate the cell cycle via phosphorylation of CDK1 and are considered potential drug targets. Herein, we investigated the structure-function relationship of human Wee1, Wee2 and Myt1 (PKMYT1). Purified recombinant full-length proteins and kinase domain constructs differed substantially in phosphorylation states and catalytic competency suggesting complex mechanisms of activation. A series of crystal structures revealed unique features that distinguish Wee1 and Wee2 from Myt1 and establish the structural basis of differential inhibition by the widely used Wee1 inhibitor MK-1775...
August 9, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28789602/innovation-and-entrepreneurship-programs-in-us-medical-education-a-landscape-review-and-thematic-analysis
#12
Blake A Niccum, Arnab Sarker, Stephen J Wolf, Matthew J Trowbridge
BACKGROUND: Training in innovation and entrepreneurship (I&E) in medical education has become increasingly prevalent among medical schools to train students in complex problem solving and solution design. OBJECTIVE: We aim to characterize I&E education in US allopathic medical schools to provide insight into the features and objectives of this growing field. DESIGN: I&E programs were identified in 2016 via structured searches of 158 US allopathic medical school websites...
2017: Medical Education Online
https://www.readbyqxmd.com/read/28783253/dual-stage-light-amplified-photodynamic-therapy-against-hypoxic-tumor-based-on-an-o2-self-sufficient-nanoplatform
#13
Li-Han Liu, Yao-Hui Zhang, Wen-Xiu Qiu, Lu Zhang, Fan Gao, Bin Li, Lu Xu, Jin-Xian Fan, Zi-Hao Li, Xian-Zheng Zhang
Tumor hypoxia severely limits the efficacy of traditional photodynamic therapy (PDT). Here, a liposome-based nanoparticle (designated as LipoMB/CaO2 ) with O2 self-sufficient property for dual-stage light-driven PDT is demonstrated to address this problem. Through a short time irradiation, (1) O2 activated by the photosensitizer methylene blue (MB) can induce lipid peroxidation to break the liposome, and enlarge the contact area of CaO2 with H2 O, resulting in accelerated O2 production. Accelerated O2 level further regulates hypoxic tumor microenvironment and in turn improves (1) O2 generation by MB under another long time irradiation...
August 7, 2017: Small
https://www.readbyqxmd.com/read/28780894/gene-therapy-for-hypertension
#14
Ludovit Paulis, Heinrich Franke, Fedor Simko
The control of hypertension and the resulting cardiovascular events is still insufficient. Thus, the search for novel means for blood pressure (BP) reduction remains worth further clinical and research attention. The advances in vector and construct design sketch the use of gene therapy in hypertension. Areas covered: The authors have searched for studies using gene therapy in hypertension reporting BP outcomes. They have identified 63 experimental studies demonstrating feasible targeting of the classical and new renin-angiotensin-aldosterone system, β1-adrenergic receptor, NO-cGMP axis, endothelin, natriuretic peptides, kallikrein system, cytochrome P-450 hydroxylase, oncogenes, growth factors, interleukins, angiopoietin-1, adrenomedullin or Klotho in small rodents...
August 7, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28780327/imaging-appropriateness-in-an-academic-emergency-medicine-program
#15
Ali Arhami Dolatabadi, Majid Shojaee, Hamid Kariman, Ali Shahrami, Sarah Abolmaali
INTRODUCTION: As radiologic assessment is a key part in evaluating patients visited in emergency department, this survey was conducted to measure emergency medicine residents' competency in choosing appropriate diagnostic imaging in different clinical scenarios. METHODS: All emergency medicine residents enrolled in an academic emergency medicine discipline in the three medical universities of Tehran, Iran were recruited. A questionnaire was designed consisting of 10 clinically common scenarios selected from the American College of Radiology appropriateness criteria...
August 3, 2017: International Emergency Nursing
https://www.readbyqxmd.com/read/28777234/provider-opinions-and-experiences-regarding-development-of-a-social-support-assessment-to-inform-hospital-discharge-the-going-home-toolkit
#16
Andrea Wallace, Todd Papke, Erica Davisson, Kara Spooner, Laura Gassman
PURPOSE OF STUDY: Despite over three decades of research linking social support and optimal health outcomes, social support is not systematically assessed or addressed during clinical care. This study sought input from health care providers to inform the design of an intervention intended to facilitate assessment of social support in a way that could aid in anticipatory planning during the process of hospital discharge. PRIMARY PRACTICE SETTING(S): Using a purposive sampling strategy, data were collected from providers in two acute care settings serving rural patients, one academic and one community based...
September 2017: Professional Case Management
https://www.readbyqxmd.com/read/28776837/distinguishing-attachment-and-affiliation-in-early-adolescents-narrative-descriptions-of-their-best-friendship
#17
Meredith J Martin, Patrick T Davies, E Mark Cummings
This study was designed to test for specificity in the relationship between individual friendship provisions and adjustment across early adolescence. Using a narrative procedure, attachment (i.e., accessing care) and affiliation (i.e., forming cooperative partnerships) were found to be distinct functional themes organizing 293 adolescents' (Mage  = 13) internal representations of their best friendship across three annual measurement occasions. Longitudinal, cross-lag analyses revealed a unique transactional relationship between friendship affiliation and greater social competence over time, controlling for friendship stability, maternal relationship quality, socioeconomic status, and gender...
September 2017: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/28776046/jak-inhibitors-modulate-production-of-replication-competent-zika-virus-in-human-hofbauer-trophoblasts-and-neuroblastoma-cells
#18
Christina Gavegnano, Leda C Bassit, Bryan D Cox, Hui-Mien Hsiao, Erica L Johnson, Mehul Suthar, Rana Chakraborty, Raymond F Schinazi
Zika Virus (ZIKV) is a flavivirus that has been implicated in causing brain deformations, birth defects, and microcephaly in fetuses, and associated with Guillain-Barre syndrome. Mechanisms responsible for transmission of ZIKV across the placenta to the fetus are incompletely understood. Herein, we define key events modulating infection in clinically relevant cells, including primary placental macrophages (human Hofbauer cells; HC), trophoblasts, and neuroblastoma cells. Consistent with previous findings, HC and trophoblasts are permissive to ZIKV infection...
2017: Pathogens & Immunity
https://www.readbyqxmd.com/read/28775145/bypassing-drug-resistance-mechanisms-of-prostate-cancer-with-small-molecules-that-target-androgen-receptor-chromatin-interactions
#19
Kush Dalal, Meixia Che, Nanette S Que, Aishwariya Sharma, Rendong Yang, Nada Lallous, Hendrik Borgmann, Deniz Ozistanbullu, Ronnie Tse, Fuqiang Ban, Huifang Li, Kevin J Tam, Mani Roshan-Moniri, Eric Leblanc, Martin E Gleave, Daniel T Gewirth, Scott M Dehm, Artem Cherkasov, Paul S Rennie
Human androgen receptor (AR) is a hormone-activated transcription factor that is an important drug-target in the treatment of prostate cancer. Current small molecule AR-antagonists, such as enzalutamide, compete with androgens that bind to the steroid binding pocket of the AR ligand binding domain (LBD). In castration-resistant prostate cancer (CRPC), drug-resistance can manifest through AR-LBD mutations that convert AR-antagonists into agonists, or by expression of AR-variants lacking the LBD. Such treatment resistance underscores the importance of novel ways of targeting the AR...
August 3, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28771981/there-is-more-to-perinatal-mental-health-care-than-depression-public-health-nurses-reported-engagement-and-competence-in-perinatal-mental-health-care
#20
Agnes Higgins, Carmel Downes, Margaret Carroll, Ailish Gill, Mark Monahan
AIM: To explore public health nurses' engagement, competence and education needs in relation to perinatal mental health care in Ireland. BACKGROUND: It is estimated that 15-25% of women will experience a mental health problem during or post pregnancy, either as a new problem or a reoccurrence of a pre-existing problem. Public Health Nurses, or their equivalent, are ideally positioned to support women's mental health and improve health outcomes for the woman and baby, yet little is known about their role and engagement with mental health issues, other than with postnatal depression...
August 3, 2017: Journal of Clinical Nursing
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