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https://www.readbyqxmd.com/read/28938744/an-improved-ivm-method-for-cumulus-oocyte-complexes-from-small-follicles-in-polycystic-ovary-syndrome-patients-enhances-oocyte-competence-and-embryo-yield
#1
F Sánchez, F Lolicato, S Romero, M De Vos, H Van Ranst, G Verheyen, E Anckaert, J E J Smitz
STUDY QUESTION: Are meiotic and developmental competence of human oocytes from small (2-8 mm) antral follicles improved by applying an optimized IVM method involving a prematuration step in presence of C-Type Natriuretic Peptide (CNP) followed by a maturation step in presence of FSH and Amphiregulin (AREG)? SUMMARY ANSWER: A strategy involving prematuration culture (PMC) in the presence of CNP followed by IVM using FSH + AREG increases oocyte maturation potential leading to a higher availability of Day 3 embryos and good-quality blastocysts for single embryo transfer...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28937640/solvent-free-synthesis-and-safener-activity-of-sulfonylurea-benzothiazolines
#2
Ying Fu, Jing-Yi Wang, Dong Zhang, Yu-Feng Chen, Shuang Gao, Li-Xia Zhao, Fei Ye
A series of novel sulfonylurea benzothiazolines was designed by splicing active groups and bioisosterism. A solvent-free synthetic route was developed for the sulfonylurea benzothiazoline derivatives via the cyclization and carbamylation. All compounds were characterized by IR, ¹H-NMR, (13)C-NMR, HRMS. The biological activity tests indicated the compounds could protect maize against the injury caused by chlorsulfuron to some extent. The molecular docking result showed that the new compound competed with chlorsulfuron to bind with the herbicide target enzyme active site to attain detoxification...
September 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28937409/development-and-feasibility-of-self-management-application-in-left-ventricular-assist-devices
#3
Jesus M Casida, James E Aikens, Heidi Craddock, Matthew W Aldrich, Francis D Pagani
Despite major advancements in mechanical circulatory support, the self-management (SM) for patients with a left-ventricular assist device (LVAD) remains complex and challenging for patients and their caregivers. We have developed a mobile phone application (VAD Care App) to organize and simplify the LVAD SM process. This article describes the development and feasibility study of the app as an SM tool for LVAD patients and caregivers requiring support from ventricular assist device (VAD) coordinators. The specific aim was to evaluate the app's acceptability and usability and the users' competency...
September 20, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28933674/critical-healthcare-management-studies-green-shoots
#4
Martin Kitchener, Aoife M McDermott, Simon Cooper
Purpose While critical approaches have enriched research in proximate fields, their impact has been less marked in studies of healthcare management. In response, the 2016 Organizational Behaviour in Health Care Conference hosted its first-ever session dedicated to the emergent field of critical healthcare management studies (CHMSs). The purpose of this paper is to present five papers selected from that conference. Design/methodology/approach In this introductory paper, the authors frame the contributions as "green shoots" in a field of CHMS which contains four main furrows of activity: questioning the taken-for-granted; moving beyond instrumentalism; reflexivity and meanings in research; and challenging structures of domination (Kitchener and Thomas, 2016)...
August 21, 2017: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/28930816/a-comparative-study-of-interprofessional-education-in-global-health-care-a-systematic-review
#5
Chulani Herath, Yangfeng Zhou, Yong Gan, Naomie Nakandawire, Yanghong Gong, Zuxun Lu
BACKGROUND: The World Health Organization (WHO) and its partners identify interprofessional (IP) collaboration in education and practice as an innovative strategy that plays an important role in mitigating the global health workforce crisis. Evidence on the practice of global health level in interprofessional education (IPE) is scarce and hampered due to the absence of aggregate information. Therefore, this systematic review was conducted to examine the incidences of IPE and summarize the main features about the IPE programs in undergraduate and postgraduate education in developed and developing countries...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28929762/modulating-the-performance-of-an-asymmetric-organocatalyst-by-tuning-its-spatial-environment-in-a-metal-organic-framework
#6
Lujia Liu, Tian-You Zhou, Shane G Telfer
Systematically tuning the spatial environment around the active sites of synthetic catalysts is a difficult challenge. Here, we show how this can be accomplished in the pores of multicomponent metal-organic frameworks. This relies on embedding a catalytic unit in a pore of the MUF-77 framework and then tuning its environment by introducing different functional groups to the surrounding linkers. This approach benefits from the structural regularity of MUF-77, which places each component in a precise location to circumvent disorder...
September 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28928938/the-elixir-excelerate-train-the-trainer-pilot-programme-empower-researchers-to-deliver-high-quality-training
#7
Sarah L Morgan, Patricia M Palagi, Pedro L Fernandes, Eija Koperlainen, Jure Dimec, Diana Marek, Lee Larcombe, Gabriella Rustici, Teresa K Attwood, Allegra Via
One of the main goals of the ELIXIR-EXCELERATE project from the European Union's Horizon 2020 programme is to support a pan-European training programme to increase bioinformatics capacity and competency across ELIXIR Nodes. To this end, a Train-the-Trainer (TtT) programme has been developed by the TtT subtask of EXCELERATE's Training Platform, to try to expose bioinformatics instructors to aspects of pedagogy and evidence-based learning principles, to help them better design, develop and deliver high-quality training in future...
2017: F1000Research
https://www.readbyqxmd.com/read/28926152/the-patients-perspective-of-sustaining-a-fall-in-hospital-a-qualitative-study
#8
Stephanie Gettens, Paul Fulbrook, Melanie Jessup, Nancy Low Choy
AIM: To understand the patient's perspective of falling in hospital. BACKGROUND: A fall in hospital can affect a patient physically and psychologically, increasing their hospital length of stay and potentially putting them at risk of further complications. Despite a wealth of literature on falls that focuses on risk assessment, preventive interventions and cost, very little research has focused on the experience of the patient that has fallen, particularly within the acute hospital setting...
September 19, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28925520/rational-design-of-bifunctional-2-fold-interpenetrated-zn-ii-metal-organic-framework-for-selective-adsorption-of-co2-and-efficient-aqueous-phase-sensing-of-2-4-6-trinitrophenol
#9
C M Nagaraja, Sandeep Dhankhar, Nayuesh Sharma, Sandeep Kumar, Dhilip Kumar
A bifunctional, microporous Zn(II) metal-organic framework, [Zn2(NH2BDC)2(dpNDI)]n (MOF1) (where, NH2BDC =2-aminoterephthalic acid, dpNDI =N,N'-di(4-pyridyl)-1,4,5,8-naphthalenediimide) has been synthesized solvothermally. MOF1 shows a 2-fold interpenetrated, 3D pillar-layered framework structure composed of two types of 1D channels with dimensions of ~3.80 x 16.9 Å2 and 7.49 x 17.01 Å2 decorated with pendent -NH2 group. Owing to the presence of basic functionalized pore surface, MOF1 exhibits selective adsorption of CO2 with high value of heat of adsorption (Qst = 46...
September 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28923989/competing-risks-of-cardiovascular-versus-noncardiovascular-death-during-long-term-follow-up-after-acute-coronary-syndromes
#10
Alexander C Fanaroff, Matthew T Roe, Robert M Clare, Yuliya Lokhnygina, Ann Marie Navar, Robert P Giugliano, Stephen D Wiviott, Andrew M Tershakovec, Eugene Braunwald, Michael A Blazing
BACKGROUND: Understanding the relative risk of cardiovascular versus noncardiovascular death is important for designing clinical trials. These risks may differ depending on patient age, sex, and type of acute coronary syndrome (ACS). METHODS AND RESULTS: IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial) was a randomized controlled trial of simvastatin plus either ezetimibe or placebo following stabilized ACS. Cause of death was adjudicated by an independent committee...
September 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28923918/continuous-track-paths-reveal-additive-evidence-integration-in-multistep-decision-making
#11
Cristian Buc Calderon, Myrtille Dewulf, Wim Gevers, Tom Verguts
Multistep decision making pervades daily life, but its underlying mechanisms remain obscure. We distinguish four prominent models of multistep decision making, namely serial stage, hierarchical evidence integration, hierarchical leaky competing accumulation (HLCA), and probabilistic evidence integration (PEI). To empirically disentangle these models, we design a two-step reward-based decision paradigm and implement it in a reaching task experiment. In a first step, participants choose between two potential upcoming choices, each associated with two rewards...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28920422/dual-activator-codoped-upconversion-nanoprobe-with-core-multishell-structure-for-in-vitro-and-in-vivo-detection-of-hydroxyl-radical
#12
Xin-Yue Song, Jiayu Zhang, Zihong Yue, Zonghua Wang, Zhihong Liu, Shusheng Zhang
Monitoring the fluctuation of hydroxyl radical (•OH) in the body can serve as an effective tool for the prediction of relative diseases, which, however, is highly challenging due to its short lifetime, high reactivity and extremely low concentration. Sandwich structured lanthanide-doped upconversion nanoparticles (UCNPs) exhibit unique luminescence properties and great prospects in bioimaging. Nonetheless, their rather low luminescence efficiency and intensity are serious limitations for their application...
September 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28918616/trainee-associated-factors-and-proficiency-at-percutaneous-nephrolithotomy
#13
Seyed Mohammad Kazem Aghamir, Negar Behtash, Morteza Hamidi, Hasan Farahmand, Alborz Salavati, Sara Mortaz Hejri
Percutaneous nephrolithotomy (PNL) is a complicated procedure for urology trainees. This study was designed to investigate the effect of trainees' ages and previous experience, as well as the number of operated cases, on proficiency at PNL by using patient outcomes. A cross sectional observational study was designed during a five-year period. Trainees in PNL fellowship programs were included. At the end of the program, the trainees' performance in PNL was assessed regarding five competencies and scored 1-5...
July 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28915815/designing-an-implementation-intervention-with-the-behaviour-change-wheel-for-health-provider-smoking-cessation-care-for-australian-indigenous-pregnant-women
#14
Gillian S Gould, Yael Bar-Zeev, Michelle Bovill, Lou Atkins, Maree Gruppetta, Marilyn J Clarke, Billie Bonevski
BACKGROUND: Indigenous smoking rates are up to 80% among pregnant women: prevalence among pregnant Australian Indigenous women was 45% in 2014, contributing significantly to the health gap for Indigenous Australians. We aimed to develop an implementation intervention to improve smoking cessation care (SCC) for pregnant Indigenous smokers, an outcome to be achieved by training health providers at Aboriginal Medical Services (AMS) in a culturally competent approach, developed collaboratively with AMS...
September 15, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28910335/medical-leaders-or-masters-a-systematic-review-of-medical-leadership-in-hospital-settings
#15
Mathilde A Berghout, Isabelle N Fabbricotti, Martina Buljac-Samardžić, Carina G J M Hilders
Medical leadership is increasingly considered as crucial for improving the quality of care and the sustainability of healthcare. However, conceptual clarity is lacking in the literature and in practice. Therefore, a systematic review of the scientific literature was conducted to reveal the different conceptualizations of medical leadership in terms of definitions, roles and activities, and personal-and context-specific features. Eight databases were systematically searched for eligible studies, including empirical studies published in peer-reviewed journals that included physicians carrying out a manager or leadership role in a hospital setting...
2017: PloS One
https://www.readbyqxmd.com/read/28905963/coarse-grained-molecular-dynamics-studies-of-the-structure-and-stability-of-peptide-based-drug-amphiphile-filaments
#16
Myungshim Kang, Honggang Cui, Sharon M Loverde
Peptide-based supramolecular filaments, in particular filaments self-assembled by drug amphiphiles (DAs), possess great potential in the field of drug delivery. These filaments possess one hundred percent drug loading, with a release mechanism that can be tuned based on the dissociation of the supramolecular filaments and the degradation of the DAs [Cheetham et al., J. Am. Chem. Soc., 2013, 135(8), 2907]. Recently, much attention has been drawn to the competing intermolecular interactions that drive the self-assembly of peptide-based amphiphiles into supramolecular filaments...
September 14, 2017: Soft Matter
https://www.readbyqxmd.com/read/28905472/design-paper-japan-endoscopy-database-jed-a-prospective-big-database-project-related-to-gastroenterological-endoscopy-in-japan
#17
K Matsuda, K Tanaka, M Fujishiro, Y Saito, K Ohtsuka, I Oda, C Katada, M Kato, M Kida, K Kobayashi, S Hoteya, T Horimatsu, S Kodashima, T Matsuda, M Muto, H Yamamoto, S Ryozawa, R Iwakiri, H Kutsumi, H Miyata, M Kato, K Haruma, K Fujimoto, N Uemura, M Kaminishi, H Tajiri
The advent of electrical medical records brought image filing systems to many hospitals, as well as electrical endoscopic medical records. However, data integration among multiple different venders has not yet been accomplished. We start the Japan Endoscopic Database (JED) Project endorsed by Japan Gastroenterological Endoscopy Society (JGES) from January 2015. The purposes of this project are as follows: 1) developing the world's largest endoscopic database generated from daily use of the reporting system 2) capturing the actual performance of endoscopic practice in Japan; and 3) standardizing the terminology and fundamental items for the registry of clinical studies...
September 14, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28894825/hearing-loss-as-a-risk-factor-for-dementia-a-systematic-review
#18
REVIEW
Rhett S Thomson, Priscilla Auduong, Alexander T Miller, Richard K Gurgel
OBJECTIVES: To review evidence of hearing loss as a risk factor for dementia. Data Sources: PubMed Review methods: A systematic review was conducted using the PubMed database using the search terms (hearing loss OR presbycusis) AND (dementia OR cognitive decline). Initially, 488 articles were obtained. Only those studies evaluating an association between hearing loss and incident dementia or cognitive decline were included in the analysis. This resulted in 17 articles which were thoroughly evaluated with consideration for study design, method for determining hearing loss and cognitive status, relevant covariates and confounding factors, and key findings...
April 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28894644/anthropometric-physical-function-and-general-health-markers-of-masters-athletes-a-cross-sectional-study
#19
Samantha Fien, Mike Climstein, Clodagh Quilter, Georgina Buckley, Timothy Henwood, Josie Grigg, Justin W L Keogh
Once the general decline in muscle mass, muscle strength and physical performance falls below specific thresholds, the middle aged or older adult will be diagnosed as having sarcopenia (a loss of skeletal muscle mass and strength). Sarcopenia contributes to a range of adverse events in older age including disability, hospitalisation, institutionalisation and falls. One potentially relevant but understudied population for sarcopenia researchers would be Masters athletes. Masters sport is becoming more common as it allows athletes (typically 40 years and older) the opportunity to participate in individual and/or team sports against individuals of similar age...
2017: PeerJ
https://www.readbyqxmd.com/read/28894138/mechanical-bone-growth-stimulation-by-magnetic-fibre-networks-obtained-through-a%C3%A2-competent-finite-element-technique
#20
Wolfram A Bosbach
Fibre networks combined with a matrix material in their void phase make the design of novel and smart composite materials possible. Their application is of great interest in the field of advanced paper or as bioactive tissue engineering scaffolds. In the present study, we analyse the mechanical interaction between metallic fibre networks under magnetic actuation and a matrix material. Experimentally validated FE models are combined for that purpose in one joint simulation. High performance computing facilities are used...
September 11, 2017: Scientific Reports
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