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Fulminant myocarditis

Hiroyuki Matsuura, Fukiko Ichida, Tsutomu Saji, Shunichi Ogawa, Kenji Waki, Masahide Kaneko, Masahiro Tahara, Takashi Soga, Yasuo Ono, Satoshi Yasukochi
BACKGROUND: The 1st nationwide survey by the Japanese Society of Pediatric Cardiology and Cardiac Surgery of acute or fulminant myocarditis (AMC/FMC) in children revealed that the survival rate of FMC was only 51.6%. The 2nd nationwide survey was performed to evaluate the recent outcomes of pediatric myocarditis.Methods and Results:Questionnaires regarding patients aged ≤18 years with AMC/FMC during the period from January 2006 to December 2011 were mailed. A total of 221 cases (age 6...
October 4, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
Goran Davidović, Stefan Simović, Slobodanka Mitrović, Violeta Irić-Ćupić, Vladimir Miloradović
A 19-year-old male was admitted to our clinic with a diagnosis of suspected acute pericarditis and acute coronary syndrome. The initial diagnostics at our clinic revealed fulminant myocarditis. Twenty-four hours after admission, the patient's condition deteriorated, and he required mechanical ventilation and cardiopulmonary resuscitation. Unfortunately, the patient died. Clinical course, postmortem pathohistological findings and virus serology indicated that an H1N1 viral caused fulminant myocarditis and was the primary manifestation...
May 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
R Q Zhu, C Z Liu, J H Lu, Y P Su, S C Wen, G J Nie, Y Z Hu, L E Zuo
Objective: To observe the clinical efficacy and factors associated with outcome of extracorporeal membrane oxygenation (ECMO) in refractory cardiogenic shock patients. Methods: Patients with refractory cardiogenic shock received ECMO treatment in our hospital from May 2013 to November 2015 were retrospectively analyzed. The clinical status before ECMO support, ECMO timing, complications and outcome were observed and analyzed.The hemodynamic data and the amount of vasoactive drugs at 2 hours before ECMO support and at 2, 6, 24 and 48 hours after ECMO support were collected and compared...
September 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
Juan G Ripoll, Robert A Ratzlaff, David M Menke, Maria C Olave, Joseph J Maleszewski, José L Díaz-Gómez
Giant cell myocarditis (GCM) is a rare and commonly fatal form of fulminant myocarditis. During the acute phase, while immunosuppressive therapy is initiated, venoarterial extracorporeal membrane oxygenation (VA-ECMO) support is commonly used as a bridge to heart transplantation or recovery. Until recently, conventional transesophageal echocardiography and transthoracic echocardiography were the tools available for hemodynamic assessment of patients on this form of mechanical circulatory support. Nevertheless, both techniques have their limitations...
2016: Case Reports in Critical Care
Hideki Wada, Manabu Ogita, Katsumi Miyauchi, Satoru Suwa, Miki Yamano, Hiroyuki Daida
No abstract text is available yet for this article.
November 15, 2016: International Journal of Cardiology
Hidehiro Iwakawa, Hiroyuki Watanabe, Takako Iino, Hiroshi Ito
No abstract text is available yet for this article.
August 16, 2016: Intensive Care Medicine
(no author information available yet)
The cover shows a light sheet fluorescence microcopy image of a murine heart from diphtheria toxin treated CD11c-DTR mouse affected by fulminant myocarditis. The massive leukocyte infiltration was visualized by intravenous injection of fluorescent anti-CD45 antibodies. The autofluorescence channel reveals massive organ dilatation (grey). The leukocytic infiltrate is depicted in a heat map overlay from low (blue) to very high (bright yellow) and mainly affects the zone of the stimulus transduction system and the valves...
August 2016: European Journal of Immunology
Shahla Abrar, Mohammed Junaid Ansari, Mahima Mittal, K P Kushwaha
INTRODUCTION: Paediatric myocarditis can present as mild flu like symptoms to fulminent form. Early identification of the severity of illness and prioritization of intensive care is helpful especially in developing countries with limited resources. AIM: To know the factors at admission that can predict mortality in paediatric myocarditis. MATERIALS AND METHODS: This was an observational study which enrolled children who presented with fever of acute onset (less than 15 days in duration), and were diagnosed as suspected myocarditis on the basis of clinical features, Troponin I and echocardiography, according to Expanded criteria for myocarditis in Paediatric ward at our institute over a period from August 2014 to December 2015...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
Yoshihiro Noji
No abstract text is available yet for this article.
August 2016: Critical Care Medicine
Pınar Türker Duyuler, Serkan Duyuler, Ekrem Şahan, Şeref Alp Küçüker
Acute fulminant myocarditis is a life-threatening inflammatory disease of the myocardium characterized by the rapid deterioration of the hemodynamic status of the affected individual. With prompt recognition and appropriate management, complete recovery of ventricular function is likely within a few weeks. We introduce a 28-year-old man with acute fulminant myocarditis, who experienced circulatory collapse following acute angina and dyspnea. The patient had high troponin levels with low ejection fraction and normal coronary arteries...
January 13, 2016: Journal of Tehran Heart Center
Han-Kyul Kim, Kun Il Kim, Sung Won Jung, Hee-Sun Mun, Jung Rae Cho, Namho Lee, Min-Kyung Kang
We report a case of successfully treated acute fulminant myocarditis induced by ulcerative colitis with extracorporeal life support and infliximab. Myocarditis is a rare but crucial complication during an exacerbation of inflammatory bowel disease. In our case, we applied extracorporeal membrane oxygenation (ECMO) for cardiac rest under impression of acute myocarditis associated with ulcerative colitis, and added infliximab for uncontrolled inflammation by corticosteroid. As a result, our patient was completely recovered with successful weaning of ECMO...
June 2016: Journal of Cardiovascular Ultrasound
Zi-Hao Yang, Bo-Tao Ning, Chen-Mei Zhang, Ru Lin, Sheng Ye, Tao Liu
BACKGROUND: This study aimed to discribe the experience in supporting children with refractory cardiopulmonary failure with extracorporeal membrane oxygenation (ECMO). METHODS: We retrospectively reviewed 12 children with refractory cardiopulmonary failure supported with ECMO from February 2009 to August 2015 in the Pediatric Intensive Care Unit (PICU), Children's Hospital, Zhejiang University School of Medicine. RESULTS: Seven of the 12 patients were weaned successfully from ECMO and dischaged from the hospital, with a survival rate of 58...
August 2016: World Journal of Pediatrics: WJP
Zhao-Peng Zhong, Hong Wang, Xiao-Tong Hou
Heart failure (HF) can be defined as cardiac structural or functional abnormality leading to a series of symptoms due to deficiency of oxygen delivery. In the clinical practice, acute heart failure (AHF) is usually performed as cardiogenic shock (CS), pulmonary edema, and single or double ventricle congestive heart failure. CS refers to depressed or insufficient cardiac output (CO) attributable to myocardial infarction, fulminant myocarditis, acute circulatory failure attributable to intractable arrhythmias or the exacerbation of chronic heart failure, postcardiotomy low CO syndrome, and so forth...
2016: BioMed Research International
M Ting, C-H Wang, C-I Tsao, S-C Huang, N-H Chi, N-K Chou, Y-S Chen, S-S Wang
BACKGROUND: Acute fulminant myocarditis with intractable cardiogenic shock is a fatal condition; its only therapeutic option is mechanical circulatory support. The use of mechanical circulatory support, either extracorporeal membrane oxygenation (ECMO) or a ventricular assist device (VAD), serves as a bridge to recovery or as a bridge to transplantation. OBJECTIVES: The aim of this research was to advance our understanding of the outcome of heart transplantation under mechanical support for acute myocarditis...
April 2016: Transplantation Proceedings
Linda Männ, Nora Kochupurakkal, Christian Martin, Eva Verjans, Anika Klingberg, Simon Sody, Andreas Kraus, Jill Dalimot, Eileen Bergmüller, Steffen Jung, Sylvia Voortman, Elke Winterhager, Sven Brandau, Natalio Garbi, Michael Kurrer, Urs Eriksson, Matthias Gunzer, Mike Hasenberg
To assess the role of alveolar macrophages (AMs) during a pulmonary Aspergillus fumigatus infection AMs were depleted by intratracheal application of diphtheria toxin (DTX) to transgenic CD11c.DTR mice prior to fungal infection. Unexpectedly, all CD11c.DTR mice treated with DTX died within 4-5 days, whether being infected with A. fumigatus or not. Despite measurable impact of DTX on lung functional parameters, these constrictions could not explain the high mortality rate. Instead, DTX-treated CD11c.DTR animals developed fulminant myocarditis (FM) characterized by massive leukocyte infiltration and myocardial cell destruction, including central parts of the heart's stimulus transmission system...
August 2016: European Journal of Immunology
Se Yong Jung, Hong Ju Shin, Jo Won Jung, Han Ki Park, Yu Rim Shin, Young Hwan Park, Nam Kyun Kim, Jae Young Choi
OBJECTIVES: The clinical outcome of children with severe acute myocarditis who require mechanical circulatory support is not well known. Therefore, we studied the survival and clinical courses of patients with acute fulminant myocarditis supported by extracorporeal life support (ECLS). METHODS: We performed a retrospective chart review of 13 consecutive children with acute fulminant myocarditis who were treated with ECLS between April 2013 and April 2015. Demographics, initial symptoms, laboratory results, management, clinical courses and last follow-up status were investigated...
August 2016: Interactive Cardiovascular and Thoracic Surgery
Kuan-Miao Lin, Ming-Hsiu Li, Kai-Sheng Hsieh, Hsuan-Chang Kuo, Ming-Chou Cheng, Jiunn-Jye Sheu, Ying-Jui Lin
BACKGROUND: Acute fulminant myocarditis (AFM) commonly presents as abrupt cardiogenic shock with or without dysrhythmia. This study evaluated the impact of extracorporeal membrane oxygenation (ECMO) on AFM-related hemodynamic compromise dysrhythmias. We also reported the clinical experience of AFM at our hospital. METHODS: Eighteen children diagnosed with AFM were enrolled. Demographic variables, laboratory data, and clinical courses were reviewed. Thirteen surviving patients with hemodynamic compromise arrhythmia [complete atrioventricular block (CAVB) or ventricular tachycardia (VT)] during hospitalization were divided into Group A (ECMO group; n = 7) and Group B (non-ECMO group; n = 6)...
March 16, 2016: Pediatrics and Neonatology
Alok R Amraotkar, Ajay Pachika, Kendra J Grubb, Andrew P DeFilippis
Fulminant myocarditis is a rare but potentially life-threatening illness caused by 5-fluorouracil cardiotoxicity. Data supporting the use of extracorporeal membrane oxygenation for the treatment of fulminant myocarditis are limited. A 49-year-old, previously healthy white man, recently diagnosed with anal squamous cell carcinoma, developed severe chest pain hours after completing his first 96-hour intravenous 5-fluorouracil treatment. Over a period of 3 days from onset of symptoms, the patient developed cardiogenic shock secondary to fulminant myocarditis induced by 5-fluorouracil cardiotoxicity...
April 2016: Texas Heart Institute Journal
Yuan Hung, Wei-Hsiang Lin, Chin-Sheng Lin, Shu-Meng Cheng, Tsung-Neng Tsai, Shih-Ping Yang, Wen-Yu Lin
BACKGROUND: Acute myocarditis is an inflammatory disease of the myocardium. Although a fulminant course of the disease is difficult to predict, it may lead to acute heart failure and death. Previous studies have demonstrated that reduced left ventricular systolic function and prolonged QRS duration can predict the fulminant course of acute myocarditis. This study aimed to identify whether prolonged QTc interval could also be predictive of fulminant disease in this population. METHODS: We retrospectively included 40 patients diagnosed with acute myocarditis who were admitted to our hospital between 2002 and 2013...
March 2016: Acta Cardiol Sin
Seiko Nakajima, Osamu Seguchi, Tomoyuki Fujita, Hiroki Hata, Kizuku Yamashita, Takuma Sato, Haruki Sunami, Masanobu Yanase, Norihide Fukushima, Junjiro Kobayashi, Takeshi Nakatani
Fulminant myocarditis is a rare but fatal serious disease that may cause prolonged native cardiac dysfunction with multiorgan failure despite temporary mechanical circulatory support with percutaneous venoatrial extracorporeal membrane oxygenation (VA-ECMO) or intraaortic balloon pumping (IABP). A 26-year-old man with fulminant myocarditis developed life-threatening multiorgan failure after 8 days support by VA-ECMO and IABP. He was transferred to our institution with prolonged cardiac dysfunction on hospital day 8; massive pulmonary edema developed into severe pulmonary dysfunction...
September 2016: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
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