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Fulminant myocarditis

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https://www.readbyqxmd.com/read/29457263/acute-myocarditis-with-thrombus-near-left-ventricular-outflow-tract
#1
Nicholas J Whitehead, Stuart Murch, James W Leitch, Rosemary A Hackworthy
A young woman presented with fulminant heart failure. Transthoracic echocardiography revealed severe left ventricular dysfunction with a mass adjacent to the basal anterior wall, near the left ventricular outflow tract (LVOT). The cause of the acute heart failure and mass was unclear. Transesophageal echocardiography, with contrast, and cardiac magnetic resonance imaging findings were consistent with thrombus near the LVOT. Cardiac biopsy suggested giant cell myocarditis. The patient was treated with anticoagulation, steroids, and heart failure medications with resolution of the thrombus...
February 19, 2018: Echocardiography
https://www.readbyqxmd.com/read/29451654/fulminant-myocarditis-in-children-continuous-renal-replacement-therapy-to-the-rescue
#2
Patrick M Honore, Herbert D Spapen
No abstract text is available yet for this article.
November 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29443352/levitronix-bilateral-ventricular-assist-device-a-bridge-to-recovery-in-a-patient-with-acute-fulminant-myocarditis-and-concomitant-cerebellar-infarction
#3
Yi-Fan Huang, Po-Shun Hsu, Chien-Sung Tsai, Yi-Ting Tsai, Chih-Yuan Lin, Hong-Yan Ke, Yi-Chang Lin, Hsiang-Yu Yang
We report on the case of a 27-year-old male who presented to our emergency room with chest tightness, dyspnoea and cold sweats. The 12-lead electrocardiogram showed diffuse ventricular tachycardia with wide QRS complexes. Troponin-I level was elevated to 100 ng/ml. The coronary angiogram showed good patency of all three coronary vessels, and acute fulminant myocarditis was suspected. The patient underwent cardiopulmonary resuscitation in the catheter room and high-dose inotropic support was initiated to stabilise his haemodynamic status...
February 7, 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29437909/when-lightning-strikes-twice-in-pediatrics-case-report-and-review-of-recurrent-myocarditis
#4
Alisha Floyd, Ashwin Lal, Kimberly Molina, Michael Puchalski, Dylan Miller, Lindsay May
Myocarditis is an important but incompletely understood cause of cardiac dysfunction. Children with fulminant myocarditis often require inotropic or mechanical circulatory support, and researchers in some studies suggest that up to 42% of children who die suddenly have evidence of myocarditis. Recurrent myocarditis is extremely rare, and the vast majority of reported cases involve adult patients. Pediatric providers who suspect a recurrence of myocarditis have limited evidence to guide patient management because the literature in this domain is sparse...
February 8, 2018: Pediatrics
https://www.readbyqxmd.com/read/29384884/influence-of-echocardiographic-measurements-and-renal-impairments-on-the-prognosis-of-fulminant-myocarditis
#5
Mingzhu Xu, Tingbo Jiang, Yafeng Zhou, Xiangjun Yang
Fulminant myocarditis is a severe cardiac emergency that may lead to death if effective cardiopulmonary supports are not provided. This study aimed to evaluate the prognostic predictors in patients with fulminant myocarditis.We retrospectively analyzed the clinical characteristics, complications, laboratory findings, treatments, as well as electrocardiographic and echocardiographic data of 73 consecutive subjects diagnosed with fulminant myocarditis from June 2012 to June 2016. Logistic regression analysis was used to identify the independent predictive factors of nonsurvivor fulminant myocarditis...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29367381/fulminant-myocarditis
#6
Takatsugu Segawa, Yoh Arita, Tomomi Akari, Shinji Hasegawa
No abstract text is available yet for this article.
January 23, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29359844/hepatitis-a-cardiomyopathy-aplastic-anemia-and-acute-liver-failure-a-devastating-scenario
#7
Verónica Botero, Víctor H García, Ana M Aristizabal, Catalina Gomez, Paola Perez, Luis A Caicedo, Gabriel J Echeverri
INTRODUCTION: Hepatitis A virus (HAV) causes an acute infection and is usually asymptomatic in children. When clinical manifestations appear, these include choluria, jaundice, and abdominal pain. Although infrequent, extra-hepatic manifestations related to HAV have been described affecting the heart, bone marrow, blood vessels, and others. CASE: A 10-year-old boy from a rural area presented with a 15-day history of malaise, fever, and jaundice; laboratory exams were compatible with HAV Infection...
January 23, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29345417/catheter-based-edge-to-edge-mitral-valve-repair-for-pulmonary-pressure-reduction-and-to-postpone-heart-transplantation-in-a-teenaged-patient
#8
Moritz Messner, Florian Hintringer, Silvana Müller, Marc Michael Zaruba, Nikolaos Bonaros, Herwig Antretter, Daniel Basic, Gerhard Pölzl
We report a case of catheter-based edge-to-edge mitral valve repair in a teenage male patient with non-ischaemic cardiomyopathy to improve pulmonary hypertension secondary to severe functional mitral regurgitation (FMR) to defer anticipated heart transplantation. A 19-year-old patient with previous history of fulminant myocarditis followed by markedly left ventricular dysfunction presented with severe mitral regurgitation 3 years after initial recovery. Slightly over time, deterioration of FMR was associated with gradual increase in pulmonary artery pressures despite optimal medical therapy...
January 18, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29325363/-related-factors-for-the-development-of-fulminant-myocarditis-in-adults
#9
L J Sun, L J Guo, M Cui, Y Li, B D Zhou, J L Han, Z Zhang, Y Z Zhang, W Gao
Objective: To determine the early recognizable factors related to patients with fulminant myocarditis. Methods: Medical records from 60 adult patients who were diagnosed with acute viral myocarditis from January 2003 to September 2016 in our hospital were retrospectively reviewed, and divided into the fulminant group (n=9) and the non-fulminant group (n=51). Clinical presentations, biochemical markers, electrocardiography and echocardiography features on admission were analyzed. Results: Prevalence of syncope (33...
December 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29306448/fulminant-giant-cell-myocarditis-on-mechanical-circulatory-support-management-and-outcomes-of-a-french-multicentre-cohort
#10
Santiago Montero, Nadia Aissaoui, Jean-Marc Tadié, Philippe Bizouarn, Vincent Scherrer, Romain Persichini, Clément Delmas, Florence Rolle, Emmanuel Besnier, Alexandre Le Guyader, Alain Combes, Matthieu Schmidt
AIMS: Giant-cell myocarditis (GCM) is a rare and often fatal form of myocarditis. Only a few reports have focused on fulminant forms. We describe the clinical characteristics, management and outcomes of GCM patients rescued by mechanical circulatory support (MCS). METHODS AND RESULTS: The clinical features, diagnoses, treatments and outcomes of MCS-treated patients in refractory cardiogenic shock secondary to fulminant GCM admitted to eight French intensive care units (2002-2016) were analysed...
February 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29295868/the-immunoproteasome-specific-inhibitor-onx-0914-reverses-susceptibility-to-acute-viral-myocarditis
#11
Nadine Althof, Carl Christoph Goetzke, Meike Kespohl, Karolin Voss, Arnd Heuser, Sandra Pinkert, Ziya Kaya, Karin Klingel, Antje Beling
Severe heart pathology upon virus infection is closely associated with the immunological equipment of the host. Since there is no specific treatment available, current research focuses on identifying new drug targets to positively modulate predisposing immune factors. Utilizing a murine model with high susceptibility to coxsackievirus B3-induced myocarditis, this study describes ONX 0914-an immunoproteasome-specific inhibitor-as highly protective during severe heart disease. Represented by reduced heart infiltration of monocytes/macrophages and diminished organ damage, ONX 0914 treatment reversed fulminant pathology...
January 2, 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29275889/immune-checkpoint-inhibitor-associated-myocarditis-a-new-challenge-for-cardiologists
#12
Mauro Frigeri, Philippe Meyer, Carlo Banfi, Raphaël Giraud, Anne-Lise Hachulla, David Spoerl, Alex Friedlaender, Angela Pugliesi-Rinaldi, Pierre-Yves Dietrich
The ever-increasing use of immune checkpoint inhibitors in cancer is leading to a high incidence of autoimmune side effects. This report discusses an autoimmune fulminant myocarditis in an elderly patient with metastatic pulmonary adenocarcinoma in whom the most advanced invasive heart failure therapies were used successfully. She was treated with nivolumab. This case illustrates a severe cardiovascular complication of immunotherapy and highlights to cardiologists the importance of aggressive treatments in patients with metastatic cancers whose prognosis has improved dramatically...
January 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29236180/diagnosis-medical-treatment-and-stepwise-mechanical-circulatory-support-for-fulminat-myocarditis
#13
Shunsuke Saito, Koichi Toda, Shigeru Miyagawa, Yasushi Yoshikawa, Hiroki Hata, Daisuke Yoshioka, Keitaro Domae, Yasumasa Tsukamoto, Yasushi Sakata, Yoshiki Sawa
Fulminant myocarditis is one of the most challenging diseases. We sought to examine the outcomes of our multidisciplinary treatment strategy for fulminant myocarditis. A retrospective review of consecutive 30 patients with fulminant myocarditis was conducted. Of the 30 patients, 25 required mechanical circulatory support (MCS). Percutaneous extracorporeal membrane oxygenation (ECMO) was the first-line therapy to rescue the patients and inserted in 23 of them. The other 2 were implanted with temporary ventricular assist device (t-VAD) with extracorporeal centrifugal pump(s)...
December 13, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29181300/recurrence-of-escherichia-coli-meningitis-in-a-preterm-infant-and-co-infection-of-echovirus-18
#14
Kentaro Kato, Hiroshi Mizumoto, Kousaku Matsubara, Atsuko Hata, Jun-Ichi Wachino, Yoshichika Arakawa, Daisuke Hata
Introduction: Bacterial meningitis may relapse after adequate antibiotic treatment. In most cases, however, the pathophysiology cannot be identified. Presentation of case: We describe a preterm infant with recurrent episodes of meningitis due to infection with an identical Escherichia coli strain both at birth and at 10 days after cessation of a 3 week course of appropriate antibiotic treatment. At the time of recurrence, the patient presented with fulminant severe cardiac failure due to acute myocarditis, coupled with a concurrent echovirus 18 infection (confirmed by stool culture and serological analysis)...
2017: IDCases
https://www.readbyqxmd.com/read/29180869/ecmo-as-an-effective-rescue-therapeutic-for-fulminant-myocarditis-complicated-with-refractory-cardiac-arrest
#15
Ya-Ting Li, Li-Fen Yang, Zhuang-Gui Chen, Li Pan, Meng-Qi Duan, Yan Hu, Cheng-Bin Zhou, Yu-Xiong Guo
Fulminant myocarditis (FM) is a life-threatening disease in children. With a rapid, progressive course of deterioration, it causes refractory cardiorespiratory failure even with optimal clinical intervention. We present the case of a 9-year-old girl with FM complicated by cardiogenic shock, malignant arrhythmia, and refractory cardiac arrest. She received effective cardiopulmonary resuscitation, therapeutic hypothermia, and other supportive treatments. However, the patient rapidly worsened into pulseless ventricular tachycardia and refractory cardiac arrest...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29172240/disseminated-mucormycosis-masquerading-as-rejection-early-after-orthotopic-heart-transplantation
#16
Lindsay Margoles, David DeNofrio, Ayan Patel, Yoav Golan, Amanda Vest, Knarik Arkun, Helen Boucher, Michael Kiernan, Jenica Upshaw
Mucorales organisms are an uncommon cause of invasive fungal infections after solid organ transplantation but are associated with great morbidity and mortality. We report a fatal case of disseminated Cunninghamella infection early after heart transplantation. The patient developed graft dysfunction and elevated markers of myocyte injury and autopsy revealed fulminant fungal myocarditis. This case highlights the need for a high index of suspicion in immunocompromised patients who are not improving with standard antimicrobial therapy...
November 24, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29157297/smoldering-myocarditis-following-immune-checkpoint-blockade
#17
Timothy G Norwood, Brian C Westbrook, Douglas B Johnson, Silvio H Litovsky, Nina L Terry, Svetlana B McKee, Alan S Gertler, Javid J Moslehi, Robert M Conry
BACKGROUND: Severe myocarditis associated with electrical conduction abnormalities and occasionally heart failure has been well documented following treatment with immune checkpoint blockade with an estimated incidence of less than 1%. However, the incidence, early detection, and management of less severe immune-related myocarditis are unknown since most immunotherapy trials have not included routine cardiac monitoring. Herein, we provide the first description of subclinical or smoldering myocarditis with minimal signs and symptoms following immune checkpoint blockade with a single dose of ipilimumab and nivolumab...
November 21, 2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29156663/new-concepts-in-fulminant-myocarditis-and-risk-of-cardiac-mortality
#18
EDITORIAL
Enrico Ammirati, Manlio Cipriani, Paolo G Camici
No abstract text is available yet for this article.
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29154424/acute-fulminant-necrotizing-eosinophilic-myocarditis-early-diagnosis-and-treatment
#19
Paul David Callan, Aigul Baltabaeva, Mohammed Kamal, Joyce Wong, Rebecca Lane, Jan Lukas Robertus, Nicholas R Banner
Necrotizing eosinophilic myocarditis is a rare but potentially fatal condition that requires prompt recognition and treatment. We describe a case of a young athlete presenting with chest pain and breathlessness, with evidence of rapidly deteriorating cardiac function. The condition was successfully treated with corticosteroids, with no evidence of residual myocardial damage. This is the first reported case to demonstrate the utility of cardiac magnetic resonance imaging for diagnosis and monitoring response to treatment...
November 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29146416/fulminant-adrenergic-myocarditis-complicated-by-pulmonary-edema-cardiogenic-shock-and-cardiac-arrest
#20
Pawel Rostoff, Bohdan Nessler, Patrycja Pikul, Karolina Golinska-Grzybala, Tomasz Miszalski-Jamka, Jadwiga Nessler
Adrenergic myocarditis is an uncommon presentation of pheochromocytoma and extremely rare cause of de novo acute heart failure (AHF). We present a case of a 31-year-old Caucasian woman with a history of hypertension and recurrent occipital headaches who was admitted to the emergency department due to severe de novo AHF presenting as pulmonary edema and cardiogenic shock. During the hospital admission the patient experienced asystolic cardiac arrest and was successfully resuscitated, intubated, and mechanically ventilated...
November 10, 2017: American Journal of Emergency Medicine
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