keyword
MENU ▼
Read by QxMD icon Read
search

Most recent research

keyword
https://www.readbyqxmd.com/read/28654962/the-contribution-of-nonrigid-motion-and-shape-information-to-object-perception-in-pigeons-and-humans
#1
Jean-Francois Nankoo, Christopher R Madan, Jeffrey Sawalha, Douglas R Wylie, Alinda Friedman, Marcia L Spetch, Quoc C Vuong
The ability to perceive and recognize objects is essential to many animals, including humans. Until recently, models of object recognition have primarily focused on static cues, such as shape, but more recent research is beginning to show that motion plays an important role in object perception. Most studies have focused on rigid motion, a type of motion most often associated with inanimate objects. In contrast, nonrigid motion is often associated with biological motion and is therefore ecologically important to visually dependent animals...
June 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28654825/post-transcriptional-regulation-of-the-pluripotent-state
#2
REVIEW
Qing Chen, Guang Hu
Pluripotency describes the developmental capacity to give rise to all cell types in the adult body. A comprehensive understanding of the molecular mechanisms that regulate pluripotency is important for both basic and translational research. While earlier studies mostly focused on signaling pathways, transcriptional regulation, and epigenetic modifications, recent investigations showed that RNA binding proteins, RNA processing machineries, and regulatory RNA molecules also play essential roles. Here, we provide a concise review on the latest findings and developments in post-transcriptional regulation of the pluripotent state...
June 24, 2017: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/28654387/phosphatidylserine-targeted-nanotheranostics-for-brain-tumor-imaging-and-therapeutic-potential
#3
Lulu Wang, Amyn A Habib, Akiva Mintz, King C Li, Dawen Zhao
Phosphatidylserine (PS), the most abundant anionic phospholipid in cell membrane, is strictly confined to the inner leaflet in normal cells. However, this PS asymmetry is found disruptive in many tumor vascular endothelial cells. We discuss the underlying mechanisms for PS asymmetry maintenance in normal cells and its loss in tumor cells. The specificity of PS exposure in tumor vasculature but not normal blood vessels may establish it a useful biomarker for cancer molecular imaging. Indeed, utilizing PS-targeting antibodies, multiple imaging probes have been developed and multimodal imaging data have shown their high tumor-selective targeting in various cancers...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28653794/predicting-the-brain-activation-pattern-associated-with-the-propositional-content-of-a-sentence-modeling-neural-representations-of-events-and-states
#4
Jing Wang, Vladimir L Cherkassky, Marcel Adam Just
Even though much has recently been learned about the neural representation of individual concepts and categories, neuroimaging research is only beginning to reveal how more complex thoughts, such as event and state descriptions, are neurally represented. We present a predictive computational theory of the neural representations of individual events and states as they are described in 240 sentences. Regression models were trained to determine the mapping between 42 neurally plausible semantic features (NPSFs) and thematic roles of the concepts of a proposition and the fMRI activation patterns of various cortical regions that process different types of information...
June 27, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28653449/the-value-of-biomarkers-in-bone-metastasis
#5
Stella D'Oronzo, Janet Brown, Robert Coleman
The worst complication of cancer is represented by its spread to distant sites. In particular, bone provides a fertile soil for several cancer types, especially those derived from breast, prostate and lung tumours. Despite the progress in diagnostic and therapeutic strategies, bone metastases (BM) still impact on quality of life and overall survival, making it necessary to identify the "high-risk" patients at an earlier stage. Since BM affect physiological bone turnover, measurement of bone turnover markers (BTM) has been widely investigated for diagnostic and prognostic purposes, as well as to support the development of anti-cancer drugs...
June 27, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28653275/a-conceptual-model-for-home-based-primary-care-of-older-refugees
#6
REVIEW
M A Nies, C Febles, K Fanning, S S Tavernier
The needs of refugees in the United States can often optimally be met through home based primary care (HBPC). Until recently, however, there has been little research into the methods of best practice and challenges of providing home based care to refugee groups. The model for the HBPC of refugees proposed here is the result of a comprehensive review of the literature combined with professional practice. Emphasis is placed on the elements of care identified as most affecting health and quality of life outcomes for refugees receiving HBPC...
June 26, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28653271/regadenoson-use-in-chronic-kidney-disease-and-end-stage-renal-disease-a-focused-review
#7
Aviral Vij, Yasmeen Golzar, Rami Doukky
Regadenoson is a selective A2A adenosine receptor agonist that has been approved as a vasodilator stress agent with single-photon emission-computed tomography (SPECT) myocardial perfusion imaging (MPI). Since its approval by the Food and Drug Administration (FDA) in 2008, it has become the most commonly used pharmacologic stress agent with SPECT-MPI. Given that it is predominantly renally excreted, its use in patients with chronic kidney disease has been the subject of active post-marketing clinical research...
June 26, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28653187/virus-host-gene-interactions-define-hiv-1-disease-progression
#8
Daniela C Monaco, Zachary Ende, Eric Hunter
In this chapter, we will review recent research on the virology of HIV-1 transmission and the impact of the transmitted virus genotype on subsequent disease progression. In most instances of HIV-1 sexual transmission, a single genetic variant, or a very limited number of variants from the diverse viral quasi-species present in the transmitting partner establishes systemic infection. Transmission involves both stochastic and selective processes, such that in general a minority variant in the donor is transmitted...
June 27, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28653168/science-as-a-matter-of-honour-how-accused-scientists-deal-with-scientific-fraud-in-japan
#9
Pablo A Pellegrini
Practices related to research misconduct seem to have been multiplied in recent years. Many cases of scientific fraud have been exposed publicly, and journals and academic institutions have deployed different measures worldwide in this regard. However, the influence of specific social and cultural environments on scientific fraud may vary from society to society. This article analyzes how scientists in Japan deal with accusations of scientific fraud. For such a purpose, a series of scientific fraud cases that took place in Japan has been reconstructed through diverse sources...
June 26, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28653117/treating-eating-disorders-at-higher-levels-of-care-overview-and-challenges
#10
REVIEW
Leslie K Anderson, Erin E Reilly, Laura Berner, Christina E Wierenga, Michelle D Jones, Tiffany A Brown, Walter H Kaye, Anne Cusack
Higher levels of care (HLC)-including inpatient hospitalization, residential treatment, partial hospitalization, and intensive outpatient treatment-are frequently utilized within routine care for eating disorders. Despite widespread use, there is limited research evaluating the efficacy of HLC, as well as clinical issues related to care in these settings. This review describes the different levels of care for eating disorders and briefly reviews the most up-to-date guidelines and research regarding how to choose a level of care...
August 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28652951/current-practices-in-assessing-professionalism-in-united-states-and-canadian-allopathic-medical-students-and-residents
#11
REVIEW
Nandini Nittur, Jonathan Kibble
Professionalism is a critically important competency that must be evaluated in medical trainees but is a complex construct that is hard to assess. A systematic review was undertaken to give insight into the current best practices for assessment of professionalism in medical trainees and to identify new research priorities in the field. A search was conducted on PubMed for behavioral assessments of medical students and residents among the United States and Canadian allopathic schools in the last 15 years. An initial search yielded 594 results, 28 of which met our inclusion criteria...
May 22, 2017: Curēus
https://www.readbyqxmd.com/read/28652942/time-to-cash-in-on-positive-interactions-for-coral-restoration
#12
Elizabeth C Shaver, Brian R Silliman
Coral reefs are among the most biodiverse and productive ecosystems on Earth, and provide critical ecosystem services such as protein provisioning, coastal protection, and tourism revenue. Despite these benefits, coral reefs have been declining precipitously across the globe due to human impacts and climate change. Recent efforts to combat these declines are increasingly turning to restoration to help reseed corals and speed-up recovery processes. Coastal restoration theory and practice has historically favored transplanting designs that reduce potentially harmful negative species interactions, such as competition between transplants...
2017: PeerJ
https://www.readbyqxmd.com/read/28652534/poly-u-and-cpg-ameliorate-the-unbalanced-t-cell-immunity-and-pneumonia-of-mice-with-rsv-vaccine-enhanced-disease
#13
Ran Jia, Lu Lu, Xiaozhen Liang, Zhiwu Sun, Lingbing Tan, Menghua Xu, Liyun Su, Jin Xu
Respiratory Syncycial Virus (RSV) is the most important pathogen responsible for children's severe lower respiratory tract infection. So far no RSV vaccine has yet been authorized for clinical use. The main impediment that blocked development of RSV vaccine is that inactivated RSV vaccine could cause RSV vaccine-enhanced disease (RVED). The mechanism of RVED remains unclear. Recently some researchers found that insufficient activation of innate immunity, including Toll-like receptors (TLRs), might be associated with the onset of RVED...
June 26, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28651820/site-selective-substitution-of-gold-atoms-in-the-au24-sr-20-nanocluster-by-silver
#14
Qi Li, Michael G Taylor, Kristin Kirschbaum, Kelly J Lambright, Xiaofan Zhu, Giannis Mpourmpakis, Rongchao Jin
The synthesis and structure determination of atomically precise alloy nanoclusters have attracted much attention in recent research. Herein, we report a new alloy nanocluster Au24-xAgx(TBBM)20 (x∼1) synthesized via a ligand-exchange-induced size/structure transformation method. Its X-ray structure is obtained successfully and the dopant Ag is found to occupy three special positions in the kernel, rather than equivalently over all the kernel sites. This selective occupancy is interesting and DFT calculation results suggest that the relative oxidation state (rationalized as difference in the charge) of the Ag when doped into the cluster is likely determining the most favorable doping positions...
June 16, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28651665/using-milk-leukocyte-differentials-for-diagnosis-of-subclinical-bovine-mastitis
#15
Juliano Leonel Gonçalves, Roberta L Lyman, Mitchell Hockett, Rudy Rodriguez, Marcos Veiga Dos Santos, Kevin L Anderson
This research study aimed to evaluate the use of the milk leukocyte differential (MLD) to: (a) identify quarter milks that are culture-positive; and (b) characterize the milk leukocyte responses to specific groups of pathogens causing subclinical mastitis. The MLD measures the absolute number and relative percentage of inflammatory cells in milk samples. Using the MLD in two dairy herds (170 and 172 lactating cows, respectively), we studied all lactating cows with a most recent monthly Dairy Herd Improvement Association somatic cell count (SCC) >200 × 103 cells/ml...
June 27, 2017: Journal of Dairy Research
https://www.readbyqxmd.com/read/28651064/progranulin-as-a-biomarker-and-potential-therapeutic-agent
#16
REVIEW
Vanessa Abella, Jesús Pino, Morena Scotece, Javier Conde, Francisca Lago, Miguel Angel Gonzalez-Gay, Antonio Mera, Rodolfo Gómez, Ali Mobasheri, Oreste Gualillo
Progranulin is a cysteine-rich secreted protein with diverse pleiotropic actions and participates in several processes, such as inflammation or tumorigenesis. Progranulin was first identified as a growth factor and, recently, it was characterised as an adipokine implicated in obesity, insulin resistance and rheumatic disease. At a central level, progranulin acts as a neurotropic and neuroprotective factor and protects from neural degeneration. In this review, we summarise the most recent research advances concerning the potential role of progranulin as a therapeutic target and biomarker in cancer, neurodegenerative and inflammatory diseases...
June 23, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28650876/the-role-of-imaging-in-strabismus
#17
Jinali R Patel, Kammi B Gunton
PURPOSE OF REVIEW: To review the most recent literature regarding the clinical experience of imaging modalities in strabismus. RECENT FINDINGS: MRI of extraocular muscles (EOMs) has elucidated the roles of variation in compartmental contraction of EOMs and further evidence of EOM pulley heterotopy in various strabismus patterns, which may contribute to the clinical and surgical management of patients as this mode of imaging becomes more readily available. Ultrasound biomicroscopy (UBM) and anterior-segment optical coherence tomography (AS-OCT) may play a role in determining the location of EOMs which could also aid in devising a preoperative surgical plan, especially in those who have had prior strabismus surgery...
June 24, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28650823/bi-level-and-bi-objective-p-median-type-problems-for-integrative-clustering-application-to-analysis-of-cancer-gene-expression-and-drug-response-data
#18
Anton V Ushakov, Xenia Klimentova, Igor Vasilyev
Recent advances in high-throughput technologies have given rise to collecting large amounts of multidimensional heterogeneous data that provide diverse information on the same biological samples. Integrative analysis of such multisource datasets may reveal new biological insights into complex biological mechanisms and therefore remains an important research field in systems biology. Most of the modern integrative clustering approaches rely on independent analysis of each dataset and consensus clustering, probabilistic or statistical modeling, while flexible distance-based integrative clustering techniques are sparsely covered...
October 27, 2016: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28650223/alcohol-related-posts-from-young-people-on-social-networking-sites-content-and-motivations
#19
Hanneke Hendriks, Winifred A Gebhardt, Bas van den Putte
Many young people place alcohol-related posts on social networking sites (SNS) which can result in undesirable effects. Although several recent studies have investigated the occurrence of alcohol-related SNS use, it is neither clear (a) what type of alcohol posts are placed on SNS, (b) the motivations to place alcohol posts, nor (c) which young people are most likely to place alcohol posts. This study addressed these three goals. A large cross-sectional study among young participants (12-30 years; N = 561) assessed the posting of different types of alcohol posts, the motivations to (not) post these posts, and potential differences in posting between subgroups (i...
June 26, 2017: Cyberpsychology, Behavior and Social Networking
https://www.readbyqxmd.com/read/28649837/methylammonium-lead-bromide-perovskite-light-emitting-diodes-by-chemical-vapor-deposition
#20
Matthew R Leyden, Lingqiang Meng, Yan Jiang, Luis K Ono, Longbin Qiu, Emilio J Juárez-Pérez, Chuanjiang Qin, Chihaya Adachi, Yabing Qi
Organo-lead-halide perovskites are promising materials for optoelectronic applications. Perovskite solar cells have reached power conversion efficiencies over 22% and perovskite light emitting diodes have recently achieved over 11% external quantum efficiency. To date, most research on perovskite light emitting diodes has focused on solution processed films. There are many advantages of a vapor based growth process to prepare perovskite, including ease of patterning, ability to batch process, and material compatibility...
June 26, 2017: Journal of Physical Chemistry Letters
keyword
keyword
5996
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"