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https://www.readbyqxmd.com/read/29241213/antibiotics-induced-obesity-a-mitochondrial-perspective
#1
Melisa J Andrade, Chinchu Jayaprakash, Smitha Bhat, Nikolaos Evangelatos, Angela Brand, Kapaettu Satyamoorthy
Antibiotics are the first line of treatment against infections and have contributed immensely to reduce the morbidity and mortality rates. Recently, extensive use of antibiotics has led to alterations of the gut microbiome, predisposition to various diseases and most importantly, increase in the emergence of antibiotic-resistant bacteria, which poses a major threat to global public health. Another major issue faced worldwide due to unregulated use of antibiotics in children as well as in adults is the influence of metabolism and body weight homeostasis, leading to obesity...
December 15, 2017: Public Health Genomics
https://www.readbyqxmd.com/read/29240594/preventive-effect-of-a-microclimate-regulating-system-on-pressure-ulcer-development-a-prospective-randomized-controlled-trial-in-dutch-nursing-homes
#2
Martin van Leen, Ruud Halfens, Jos Schols
OBJECTIVE: Prevention of pressure ulcers (PrUs) is based on relieving pressure, diminishing shear stress, and controlling the skin's microclimate. Based on the recommendations in the most recent guideline for prevention of PrUs, a pressure-relieving, shear stress-diminishing, and microclimate-controlling skin interface multilayer support system (Bedcare; Sense Textile, 's-Hertogenbosch, the Netherlands) has been developed for use on top of a viscoelastic foam mattress (Formafoam, Kabelfabriek Eupen, Belgium)...
January 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29240559/fluorescence-detection-enumeration-and-characterization-of-single-circulating-cells-in-vivo-technology-applications-and-future-prospects
#3
Carolin Hartmann, Roshani Patil, Charles P Lin, Mark Niedre
There are many diseases and biological processes that involve circulating cells in the bloodstream, such as cancer metastasis, immunology, reproductive medicine, and stem cell therapies. This has driven significant interest in new technologies for the study of circulating cells in small animal research models and clinically. Most currently used methods require drawing and enriching blood samples from the body, but these suffer from a number of limitations. In contrast, 'in vivo flow cytometry' (IVFC) refers to set of technologies that allow study of cells directly in the bloodstream of the organism in vivo...
December 14, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29239950/a-retrospective-analysis-of-clinical-research-misconduct-using-fda-issued-warning-letters-and-clinical-investigator-inspection-list-from-2010-to-2014
#4
Christopher A Romano, Singh Nair, Ellise S Delphin
BACKGROUND: The US Food and Drug Administration (FDA) conducts inspections of clinical investigation sites as a component of clinical trial regulation. The FDA describes the results of these inspections in the Clinical Investigator Inspection List (CLIIL). More serious violations are followed up in FDA warning letters issued to investigators. The primary objective of the current study is to qualitatively and quantitatively describe the CLIIL data and contents of FDA-issued warning letters from 2010 to 2014...
December 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29239815/provider-recommendations-for-patient-reported-muscle-symptoms-on-statin-therapy-insights-from-the-understanding-statin-use-in-america-and-gaps-in-patient-education-survey
#5
Terry A Jacobson, Abdullah Khan, Kevin C Maki, Eliot A Brinton, Jerome D Cohen
BACKGROUND: Statin-associated muscle symptoms are reported by 10% to 29% of patients in clinical practice and are a major determinant of statin nonadherence, discontinuation, and switching. Little is known about what advice patients receive from their providers when dealing with these symptoms. OBJECTIVE: The objective of the study was to assess patient's reports of provider advice when experiencing new or worsened muscle symptoms while taking a statin. METHODS: Data were analyzed from the Understanding Statin Use in America and Gaps in Education survey, a self-administered internet-based survey of 10,138 adults with a reported history of high cholesterol and statin use...
October 12, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29239640/bad-behavior-keeps-you-up-at-night-counterproductive-work-behaviors-and-insomnia
#6
Zhenyu Yuan, Christopher M Barnes, Yongjuan Li
Drawing from recent research on counterproductive work behaviors (CWB) and moral self-regulation literature, we examine the intraindividual consequences of engaging in CWB. We posit that CWB represents morally discrediting work behaviors that can lead to moral deficits, create distress for perpetrators and ultimately result in insomnia. Specifically, we hypothesized that on days in which employees engage in CWB, they will tend to experience moral deficits and heightened levels of rumination that undermine their sleep that night...
December 14, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/29239631/video-game-training-does-not-enhance-cognitive-ability-a-comprehensive-meta-analytic-investigation
#7
Giovanni Sala, K Semir Tatlidil, Fernand Gobet
As a result of considerable potential scientific and societal implications, the possibility of enhancing cognitive ability by training has been one of the most influential topics of cognitive psychology in the last two decades. However, substantial research into the psychology of expertise and a recent series of meta-analytic reviews have suggested that various types of cognitive training (e.g., working memory training) benefit performance only in the trained tasks. The lack of skill generalization from one domain to different ones-that is, far transfer-has been documented in various fields of research such as working memory training, music, brain training, and chess...
December 14, 2017: Psychological Bulletin
https://www.readbyqxmd.com/read/29239154/neuromuscular-block-in-laparoscopic-surgery
#8
Thomas Fuchs-Buder, Edoardo DE Robertis, Laurent Brunaud
BACKGROUND: There is an increased interest in the current literature to evaluate the potential clinical benefit of a sustained deep neuromuscular blockade ( i.e. a post-tetanic count ≤ 3) during various laparoscopic surgical procedures. This deep block concept represents a new area of clinical research, which concerns both, anesthesiologists and surgeons. METHODS: We reviewed a selection of recent publications about the indications and the potential benefits of a maintained deep neuromuscular blockade during different laparoscopic procedures...
December 13, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29238874/bacteria-mediated-phthalic-acid-esters-degradation-and-related-molecular-mechanisms
#9
REVIEW
Lei Ren, Zhong Lin, Hongming Liu, Hanqiao Hu
Phthalic acid esters (PAEs) have long been known as the most widely used plasticizer with a broad range of industrial application. PAEs are ubiquitous in different environments and our daily life due to their large and widespread application. Recent PAEs research mainly focused on their environmental fate (including leaching, migration, transformation) and toxicology and risk assessment. With the comprehensive recognition of their potential hazard, the elimination of PAEs has attracted worldwide concerns. Although many factors may contribute to the degradation of PAEs, the dominant role of biodegradation was widely reported...
December 14, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29238002/yin-yang-regulating-effects-of-cancer-associated-genes-proteins-and-cells-an-ancient-chinese-concept-in-vogue-in-modern-cancer-research
#10
Shuyong Wei
Great achievements have been made in human cancer research, but most of this research is focused on conditions at the microscopic rather than the systemic level. Recent studies have increasingly cited the ancient Chinese theory of yin-yang in an effort to expand beyond the microscopic level. Various cancer-associated genes and proteins such as mitogen-activated protein kinase (MAPK), p38, p53, c-Myc, tumor necrosis factor (TNF)-α, NF-κB, Cyclin D1, and cyclin-dependent kinase (CDK) and cells such as T cells, B cells, macrophages, neutrophils, and fibroblasts have been reported to regulate various types of cancers in a yin-yang manner...
December 14, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/29237532/-research-progresses-in-the-pathogenesis-diagnosis-and-treatment-of-infantile-hemangioma-with-phace-syndrome
#11
Su-Hua Peng, Kai-Ying Yang, Si-Yuan Chen, Yi Ji
Infant hemangioma, the most common benign tumor in children, is characterized by rapid proliferation, followed by slower spontaneous involution. However, some patients with facial segmental hemangioma are associated with PHACE syndrome. PHACE syndrome is characterized by vascular nerve and vascular cutaneous lesions of multiple systemic systems, often resulting in structural and functional impairments. Recent studies have demonstrated that the possible pathogeneses of PHACE syndrome mainly include hypoxia, abnormality of mesodermal vascular endothelial cells, genetic abnormality, and abnormality of interstitial mesenchymal stem cells...
December 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29237531/-research-advances-in-mesenchymal-stem-cell-derived-exosomes-in-treatment-of-brain-injury
#12
Yan Yue, Yi Qu, De-Zhi Mu
Mesenchymal stem cell (MSC) transplantation is considered one of the most promising therapeutic strategies for the repair of brain injuries and plays an important role in various links of nerve repair. Recent studies have shown that MSC-derived exosomes may dominate the repair of brain injuries and help to promote angiogenesis, regulate immunity, inhibit apoptosis, and repair the nerves, and therefore, they have a great potential in the treatment of brain injuries in neonates. With reference to these studies, this article reviews the mechanism of action of exosomes in the repair of brain injuries and related prospects and challenges, in order to provide new directions for the treatment of brain injuries in neonates with stem cells...
December 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29236663/-antibiotic-transport-and-membrane-permeability-new-insights-to-fight-bacterial-resistance
#13
Jean-Marie Pagès
A main challenge in medicinal chemistry is to determine the parameters modulating the in cellulo drug concentration needed for a therapeutic action. In Gram-negative antibacterial research, the concern is to evaluate the antibiotic permeation across the outer and inner membranes, that delineate the periplasm surrounding the bacterial cytoplasm. Passing through the membrane barrier to reach the inhibitory concentration inside the bacterium is the first pivotal step for antibiotics. The research and the development of new antimicrobials mostly rely on their capacity to reach critical concentrations in the vicinity of their intracellular target...
2017: Biologie Aujourd'hui
https://www.readbyqxmd.com/read/29236321/murine-models-of-osteosarcoma-a-piece-of-the-translational-puzzle
#14
Mannu K Walia, Wilson Castillo-Tandazo, Anthony J Mutsaers, T John Martin, Carl R Walkley
Osteosarcoma (OS) is the most common cancer of bone in children and young adults. Despite extensive research efforts, there has been no significant improvement in patient outcome for many years. An improved understanding of the biology of this cancer and how genes frequently mutated contribute to OS may help improve outcomes for patients. Whilst our knowledge of the mutational burden of OS is approaching saturation, our understanding of how these mutations contribute to OS initiation and maintenance is less clear...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236256/integrated-analysis-of-mirna-and-mrna-expression-profiles-to-identify-mirna-targets
#15
Zhiming Li, Chi-Meng Tzeng
miRNAs are involved in various biological processes and different diseases through interacting with their target mRNAs. Therefore, deciphering miRNA targets is important for diagnostics and therapeutics. However, it is still complex and expensive to do large scale screening for miRNA alterations and identify their downstream miRNA targets. Recently, integrating analysis of miRNA expression profiles and mRNA expression levels has been used to successfully identify the most prominent interactions. Here, we present a protocol that combines both expression data and computational prediction to refine the microarray result for identifying the miRNA targets...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29235915/social-bots-human-like-by-means-of-human-control
#16
Christian Grimme, Mike Preuss, Lena Adam, Heike Trautmann
Social bots are currently regarded an influential but also somewhat mysterious factor in public discourse and opinion making. They are considered to be capable of massively distributing propaganda in social and online media, and their application is even suspected to be partly responsible for recent election results. Astonishingly, the term social bot is not well defined and different scientific disciplines use divergent definitions. This work starts with a balanced definition attempt, before providing an overview of how social bots actually work (taking the example of Twitter) and what their current technical limitations are...
December 2017: Big Data
https://www.readbyqxmd.com/read/29235740/thalassemia-major-and-intermedia-in-patients-older-than-35-years-a-single-center-experience
#17
Liat Shargian-Alon, Oren Pasvolsky, Pia Raanani
BACKGROUND: During the past decades, beta thalassemia major (TM) and beta thalassemia intermedia (TI) have transformed from a universally fatal disease at a young age into a chronic disease. This advancement is attributed to improved chelation therapy as well as enhanced management strategies, with focused attention on disease and treatment-related complications. OBJECTIVES: To describe characteristics of adults with thalassemia as well as treatment modalities, disease and treatment-related complications, and socioeconomic information of the patients...
December 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29235389/extracellular-genomic-biomarkers-of-osteoarthritis
#18
Emma Budd, Giovanna Nalesso, Ali Mobasheri
Introduction Osteoarthritis (OA), a chronic, debilitating and degenerative disease of the joints, is the most common form of arthritis. The seriousness of this prevalent and chronic disease is often overlooked. Disease modifying OA drug development is hindered by the lack of soluble biomarkers to detect OA early. The objective of OA biomarker research is to identify early OA prior to the appearance of radiographic signs and the development of pain. Areas covered This review has focused on extracellular genomic material that could serve as biomarkers of OA...
December 13, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29234903/biodistribution-and-radiation-dosimetry-of-64cu-copper-dichloride-first-in-human-study-in-healthy-volunteers
#19
M A Avila-Rodriguez, C Rios, J Carrasco-Hernandez, J C Manrique-Arias, R Martinez-Hernandez, F O García-Pérez, A R Jalilian, E Martinez-Rodriguez, M E Romero-Piña, A Diaz-Ruiz
BACKGROUND: In recent years, Copper-64 (T1/2 = 12.7 h) in the chemical form of copper dichloride ([64Cu]CuCl2) has been identified as a potential agent for PET imaging and radionuclide therapy targeting the human copper transporter 1, which is overexpressed in a variety of cancer cells. Limited human biodistribution and radiation dosimetry data is available for this tracer. The aim of this research was to determine the biodistribution and estimate the radiation dosimetry of [64Cu]CuCl2, using whole-body (WB) PET scans in healthy volunteers...
December 12, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/29234738/redesigning-axial-axial-biaxial-cruciform-specimens-for-very-high-cycle-fatigue-ultrasonic-testing-machines
#20
Diogo Montalvão, Andrew Wren
The necessity to increase performances in terms of lifetime and security in mechanical components or structures is the motivation for intense research in fatigue. Applications range from aeronautics to medical devices. With the development of new materials, there is no longer a fatigue limit in the classical sense, where it was accepted that the fatigue limit is the stress level such that there is no fracture up to 1E7 cycles. The recent development of ultrasonic testing machines where frequencies can go as high as 20 kHz or over enabled tests to be extended to ranges larger than 1E9 in just a few days...
November 2017: Heliyon
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