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https://www.readbyqxmd.com/read/29667717/current-approaches-for-the-treatment-of-male-infertility-with-stem-cell-therapy
#1
REVIEW
Zahra Pourmoghadam, Leili Aghebati-Maleki, Morteza Motalebnezhad, Bahman Yousefi, Mehdi Yousefi
Infertility is the inability to conceive after having regular unprotected sexual intercourse for more than 12 months and it can be caused by reproductive problems of men, women, or both, but sometimes the cause of infertility is unknown. At least 30 million men around the world suffer from infertility, most of whom are in Africa and Eastern Europe. Since infertility problems can have devastating emotional effects on couples as well as negative effects on the society, treatment of infertility is very important, as a result of which many studies have been carried out in this field and many treatments have been proposed...
April 18, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29667710/towards-sustainable-c-h-functionalization-reactions-the-emerging-role-of-bio-based-reaction-media
#2
Stefano Santoro, Assunta Marrocchi, Daniela Lanari, Lutz Ackermann, Luigi Vaccaro
In the last decade, transition-metal catalyzed C-H functionalization reactions have progressed enourmosly, becoming a useful tool in organic synthesis and a practibable alternative to well-established methodologies. Very recently, research efforts have also been devoted to developing more sustainable C-H functionalization protocols, in order to increase their applicability. One of the most promising approaches in this sense is represented by the substitution of common reaction media with bio-based solvents...
April 18, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29667236/recent-advances-in-matrix-assisted-laser-desorption-ionisation-mass-spectrometry-imaging-maldi-msi-for-in-situ-analysis-of-endogenous-molecules-in-plants
#3
Liang Qin, Yawen Zhang, Yaqin Liu, Huixin He, Manman Han, Yanyan Li, Maomao Zeng, Xiaodong Wang
INTRODUCTION: Mass spectrometry imaging (MSI) as a label-free and powerful imaging technique enables in situ evaluation of a tissue metabolome and/or proteome, becoming increasingly popular in the detection of plant endogenous molecules. OBJECTIVE: The characterization of structure and spatial information of endogenous molecules in plants are both very important aspects to better understand the physiological mechanism of plant organism. METHODS: Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a commonly-used tissue imaging technique, which requires matrix to assist in situ detection of a variety of molecules on the surface of a tissue section...
April 17, 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29666937/biomedical-approaches-to-hiv-prevention-in-women
#4
REVIEW
Christine L Heumann
PURPOSE OF REVIEW: Effective HIV prevention techniques for women are of critical importance, as nearly half of all HIV infections globally are in women. This article reviews the recent literature on biomedical approaches to HIV prevention in women. RECENT FINDINGS: In trials in which women were adherent to oral pre-exposure prophylaxis (PrEP), PrEP was equally efficacious in men and women. However, in studies of oral PrEP exclusively in women, adherence was low, and it was not efficacious...
April 17, 2018: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29666821/probiotics-for-the-control-of-helminth-zoonosis
#5
REVIEW
Abadi Amare Reda
This paper is a comprehensive, concise, and an up to date review about probiotics effect and mechanisms against helminth infections of zoonotic importance. Zoonoses are diseases that can be transmitted from animals to humans in a reversible way. Despite zoonotic helminth diseases being still a challenge to the public health and the agriculture industries globally, they were still neglected in both human and veterinary medicine. Moreover, the increasing emergence of anthelmintic drug resistance constitutes failures of most disease control strategies, alarming for a quest to new alternative control approaches...
2018: Journal of Veterinary Medicine
https://www.readbyqxmd.com/read/29666813/ground-glass-opacities-management-in-the-lung-cancer-screening-era
#6
REVIEW
Marcello Migliore, Mariaconcetta Fornito, Manuela Palazzolo, Alessandra Criscione, Mariapia Gangemi, Francesco Borrata, Paolo Vigneri, Marco Nardini, Joel Dunning
Pulmonary ground glass opacity (GGO) is becoming an important clinical dilemma in oncology as its diagnosis in clinical practice is increasing due to the introduction of low dose computed tomography (CT) scan and screening. The incidence of cancer in GGO has been reported as high as 63%. The purpose of this manuscript is to review best available evidence papers on management of GGO in lung cancer to address the following questions: (I) how to correlate CT findings with malignancy; (II) when and who operate? (III) how to perform intraoperative detection of intrapulmonary GGO? (IV) wedge, segmentectomy or lobectomy? Taking a cue from a clinical scenario, a review on PubMed was conducted...
March 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666766/mirnaome-expression-profiles-in-the-gonads-of-adult-melopsittacus-undulatus
#7
Lan Jiang, Qingqing Wang, Jue Yu, Vinita Gowda, Gabriel Johnson, Jianke Yang, Xianzhao Kan, Xiaojun Yang
The budgerigar ( Melopsittacus undulatus ) is one of the most widely studied parrot species, serving as an excellent animal model for behavior and neuroscience research. Until recently, it was unknown how sexual differences in the behavior, physiology, and development of organisms are regulated by differential gene expression. MicroRNAs (miRNAs) are endogenous short non-coding RNA molecules that can post-transcriptionally regulate gene expression and play a critical role in gonadal differentiation as well as early development of animals...
2018: PeerJ
https://www.readbyqxmd.com/read/29666566/-enheduanna-a-manifesto-of-falling-live-brain-computer-cinema-performance-performer-and-audience-participation-cognition-and-emotional-engagement-using-multi-brain-bci-interaction
#8
Polina Zioga, Frank Pollick, Minhua Ma, Paul Chapman, Kristian Stefanov
The fields of neural prosthetic technologies and Brain-Computer Interfaces (BCIs) have witnessed in the past 15 years an unprecedented development, bringing together theories and methods from different scientific fields, digital media, and the arts. More in particular, artists have been amongst the pioneers of the design of relevant applications since their emergence in the 1960s, pushing the boundaries of applications in real-life contexts. With the new research, advancements, and since 2007, the new low-cost commercial-grade wireless devices, there is a new increasing number of computer games, interactive installations, and performances that involve the use of these interfaces, combining scientific, and creative methodologies...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29665998/lower-urinary-tract-symptoms-including-bladder-outlet-obstruction-what-s-new-in-diagnostics
#9
REVIEW
Stavros Gravas, Iason Kyriazis, Adam P Klausner
It is well known that lower urinary tract symptoms (LUTS) have a multifactorial etiology. Therefore, there is an increased need for improved diagnostics for the optimal assessment of patients with LUTS in order to identify the various causes of symptoms and improve disease phenotyping. Research has focused on the development of improved urodynamic technologies and the development of noninvasive tests that could replace urodynamic studies. This mini-review will present the most recently published studies on the topic including new technologies in the diagnosis of bladder outlet obstruction, novel metrics for bladder sensation, analysis of filling phase rhythm, measurement of detrusor wall tension, and brain imaging during urodynamic studies...
April 14, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29665963/cellulase-enhances-endophytism-of-encapsulated-metarhizium-brunneum-in-potato-plants
#10
Vivien Krell, Desirée Jakobs-Schoenwandt, Stefan Vidal, Anant V Patel
The recent discovery that entomopathogenic fungi can grow endophytically in plant tissues has spurred research into novel plant protection measures. However, current applications of fungi aiming at endophytism mostly lack targeted formulation strategies resulting in low efficacy. Here, we aimed at enhancing Metarhizium brunneum CB15 endophytism in potato plants by (i) improvement of fungal growth from beads and (ii) cellulase formation or addition to encapsulated mycelium. We found that beads supplemented with cellulose alone or in addition with inactivated baker's yeast exhibited cellulase activity and increased mycelial growth by 12...
May 2018: Fungal Biology
https://www.readbyqxmd.com/read/29665254/designing-liquid-crystalline-oligomers-to-exhibit-twist-bend-modulated-nematic-phases
#11
REVIEW
Richard J Mandle
Arguably the most active area in liquid crystal research presently, the twist-bend modulated nematic phase (TB) exhibits a nanoscale helical structure and therefore exhibits bulk chirality despite being formed of typically achiral materials. After a short introduction we address the structure-property relationship that exists for this unique mesophase before introducing recent advances in strategies employed to prepare oligomeric materials that exhibit this state of matter. These methods afford fine control over the molecular substructure and potentially over the nanostructure of the exhibited mesophases...
April 17, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29664914/ahl-lactonase-expression-in-three-marine-emerging-pathogenic-vibrio-spp-reduces-virulence-and-mortality-in-brine-shrimp-artemia-salina-and-manila-clam-venerupis-philippinarum
#12
Marta Torres, José Carlos Reina, Juan Carlos Fuentes-Monteverde, Gerardo Fernández, Jaime Rodríguez, Carlos Jiménez, Inmaculada Llamas
Bacterial infectious diseases produced by Vibrio are the main cause of economic losses in aquaculture. During recent years it has been shown that the expression of virulence genes in some Vibrio species is controlled by a population-density dependent gene-expression mechanism known as quorum sensing (QS), which is mediated by the diffusion of signal molecules such as N-acylhomoserine lactones (AHLs). QS disruption, especially the enzymatic degradation of signalling molecules, known as quorum quenching (QQ), is one of the novel therapeutic strategies for the treatment of bacterial infections...
2018: PloS One
https://www.readbyqxmd.com/read/29664793/extracellular-vesicles-a-promising-tool-for-assessment-of-embryonic-competence
#13
Diego Marin, Richard T Scott
PURPOSE OF REVIEW: Extracellular vesicles have recently emerged as a promising field of research due to their pivotal roles in intercellular communication and potential to serve as biomarkers. This review focuses on extracellular vesicles secreted by the human preimplantation embryo. The most recent findings on embryo-derived extracellular vesicles are described and discussed, as well as current technical challenges to study them. RECENT FINDINGS: So far, only a few studies have addressed extracellular vesicles of embryonic origin and explored their potential as biomarkers for embryo selection...
April 13, 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29664613/advanced-materials-and-devices-for-bioresorbable-electronics
#14
Seung-Kyun Kang, Jahyun Koo, Yoon Kyeung Lee, John A Rogers
Recent advances in materials chemistry establish the foundations for unusual classes of electronic systems, characterized by their ability to fully or partially dissolve, disintegrate, or otherwise physically or chemically decompose in a controlled fashion after some defined period of stable operation. Such types of "transient" technologies may enable consumer gadgets that minimize waste streams associated with disposal, implantable sensors that disappear harmlessly in the body, and hardware-secure platforms that prevent unwanted recovery of sensitive data...
April 17, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29664412/superconducting-selenides-intercalated-with-organic-molecules-synthesis-crystal-structure-electric-and-magnetic-properties-superconducting-properties-and-phase-separation-in-iron-based-chalcogenides-and-hybrid-organic-inorganic-superconductors
#15
Anna Krzton-Maziopa, Edyta Pesko, Roman Puzniak
Layered iron-based superconducting chalcogenides intercalated with molecular species are the subject of intensive studies, especially in the field of solid state chemistry and condensed matter physics, because of their intriguing chemistry and tunable electric and magnetic properties. Considerable progress in the research, revealing superconducting inorganic organic hybrid materials with transition temperatures to superconducting state, Tc, up to 46 K, has been brought in recent years. These novel materials are synthesized by low temperature intercalation of molecular species, such as solvates of alkali metals and nitrogen-containing donor compounds, into layered FeSe-type structure...
April 17, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29664059/excessive-daytime-sleepiness-in-parkinson-s-disease-clinical-implications-and-management
#16
REVIEW
Yun Shen, Jun-Ying Huang, Jie Li, Chun-Feng Liu
Objective: Excessive daytime sleepiness (EDS) is one of the most common sleep abnormalities in patients with Parkinson's disease (PD), yet its multifactorial etiology complicates its treatment. This review summarized recent studies on the epidemiology, etiology, clinical implications, associated features, and evaluation of EDS in PD. The efficacy of pharmacologic and non-pharmacologic treatments for EDS in PD was also reviewed. Data Sources: English language articles indexed in PubMed and Cochrane databases and Chinese-language papers indexed in Wanfang and National Knowledge Infrastructure databases that were published between January 1987 and November 2017 were located using the following search terms: "sleepiness", "sleep and Parkinson's disease", and "Parkinson's disease and treatment"...
April 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29663847/is-spatial-mobility-on-the-rise-or-in-decline-an-order-specific-analysis-of-the-migration-of-young-adults-in-sweden
#17
Hill Kulu, Emma Lundholm, Gunnar Malmberg
The aim of this study is to investigate spatial mobility over time. Research on 'new mobilities' suggests increasing movement of individuals, technology, and information. By contrast, studies of internal migration report declining spatial mobility in recent decades. Using longitudinal register data from Sweden, we calculate annual order-specific migration rates to investigate the spatial mobility of young adults over the last three decades. We standardize mobility rates for educational enrolment, educational level, family status, and place of residence to determine how much changes in individuals' life domains explain changes in mobility...
April 17, 2018: Population Studies
https://www.readbyqxmd.com/read/29663734/new-biological-research-and-understanding-of-papanicolaou-s-test
#18
REVIEW
Elizabeth R Smith, Sophia H George, Erin Kobetz, Xiang-Xi Xu
The development of the Papanicolaou smear test by Dr. George Nicholas Papanicolaou (1883-1962) is one of the most significant achievements in screening for disease and cancer prevention in history. The Papanicolaou smear has been used for screening of cervical cancer since the 1950s. The test is technically straightforward and practical and based on a simple scientific observation: malignant cells have an aberrant nuclear morphology that can be distinguished from benign cells. Here, we review the scientific understanding that has been achieved and continues to be made on the causes and consequences of abnormal nuclear morphology, the basis of Dr...
April 16, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29663195/which-target-blood-pressure-in-year-2018-evidence-from-recent-clinical-trials
#19
REVIEW
Sondre Heimark, Julian E Mariampillai, Krzysztof Narkiewicz, Peter M Nilsson, Sverre E Kjeldsen
The Systolic Blood Pressure Intervention Trial (SPRINT) suggested a favourable effect of lowering blood pressure to < 120/80 mmHg in high-risk hypertensive patients; however, new American guidelines in 2017 have not followed SPRINT but lowered its recommended treatment target to < 130/80 mmHg. We aimed to review the latest research from large randomised controlled trials and observational analyses in order to investigate the evidence for new treatment targets. We assessed recent data from the Action to Control Cardiovascular Risk in Diabetes Blood Pressure (ACCORD) study, the International Verapamil-Trandolapril Study (INVEST), the Telmisartan, Ramipril or Both in Patients at High Risk for Vascular Events trial (ONTARGET)/the Telmisartan Randomised AssessmenNt Study in aCE iNtolerant participants with cardiovascular Disease (TRANSCEND) study and The Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) study...
April 16, 2018: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/29663115/sofosbuvir-plus-daclatasvir-with-or-without-ribavirin-for-treatment-of-chronic-hcv-genotype-4-patients-real-life-experience
#20
G Shiha, R Soliman, M ElBasiony, A A Hassan, N N H Mikhail
INTRODUCTION: New regimens involving direct-acting antiviral agents have recently been approved for the treatment of HCV. Our aim was to assess the efficacy and safety of 12 or 24 weeks of Sofosbuvir 400 mg plus Daclatasvir 60 mg, with or without ribavirin (800-1000 mg) in treating chronic hepatitis C genotype 4 patients. METHODS: This is an open-label observational study that describes the effect of 12 week or 24 weeks of daily oral Sofosbuvir (SOF) 400 mg plus Daclatasvir (DCV) 60 mg with or without ribavirin (RBV) with dose adjustment if indicated...
April 16, 2018: Hepatology International
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