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https://www.readbyqxmd.com/read/28338846/patient-exposure-during-plain-radiography-and-mammography-in-japan-in-1974-2014
#1
Yuta Matsunaga, Ai Kawaguchi, Kenichi Kobayashi, Masanao Kobayashi, Yasuki Asada, Kazuyuki Minami, Shoichi Suzuki, Koichi Chida
We investigated changes in the entrance skin dose (ESD) and the mean glandular dose (MGD) during plain radiography or mammography in Japan from 1974 to 2014. Surveys regarding the conditions used for plain radiography and mammography were performed throughout Japan in 1974, 1979, 1989, 1993, 1997, 2001, 2003, 2007, 2011 and 2014. The anatomical regions considered were categorised as follows: skull anteroposterior (AP), lumbar AP, lumbar lateral (LAT), pelvis (AP), ankle, chest posteroanterior (PA), Guthmann (lateral pelviography for pregnant women), infant hip joint and mammography...
March 1, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28333124/bap31-is-involved-in-t-cell-activation-through-tcr-signal-pathways
#2
Kunwei Niu, Jialin Xu, Yuhua Cao, Yue Hou, Mu Shan, Yanqing Wang, Yang Xu, Mingyi Sun, Bing Wang
BAP31 is a ubiquitously expressed endoplasmic reticulum (ER) membrane protein. The functions of BAP31 in the immune system have not been investigated due to the lack of animal models. Therefore we created a BAP31 conditional knockdown mouse by performing a knockdown of BAP31 in the thymus. In doing so, we demonstrate that the maturation of T cells is normal but the number of T cells is less in the thymus of the knockout mouse. In addition, the spleen and lymph nodes of peripheral immune organs contained a lesser proportion of the mature T cells in the thymus specific BAP31 knockout mice...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28331083/maintenance-of-the-hiv-reservoir-is-antagonized-by-selective-bcl2-inhibition
#3
Nathan W Cummins, Amy M Sainski-Nguyen, Sekar Natesampillai, Fatma Aboulnasr, Scott Kaufmann, Andrew D Badley
Decay of the HIV reservoir is slowed over time in part by expansion of the pool of HIV infected cells. This expansion reflects homeostatic proliferation of infected cells by IL-7 or antigenic stimulation, as well as new rounds of infection of susceptible target cells. As novel therapies are being developed to accelerate the decay of the latent HIV reservoir, it will be important to identify interventions that prevent expansion and/or repopulation of the latent HIV reservoir. Our previous studies showed that HIV protease cleaves the host protein procaspase 8 to generate Casp8p41, which can bind and activate BAK to induce apoptosis of infected cells...
March 22, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28315325/-epigallocatechin-3-gallate-stimulates-myogenic-differentiation-through-taz-activation
#4
A Rum Kim, Kyung Min Kim, Mi Ran Byun, Jun-Ha Hwang, Jung Il Park, Ho Taek Oh, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Muscle loss is a typical process of aging. Green tea consumption is known to slow down the progress of aging. Their underlying mechanisms, however, remain largely unknown. In this study, we investigated the effect of (-)-epigallocatechin-3-gallate (EGCG), a polyphenolic compound of green tea, on myogenic differentiation and found that EGCG significantly increases myogenic differentiation. After EGCG treatment, the expression of myogenic marker genes, such as myosin heavy chain, are increased through activation of TAZ, a transcriptional coactivator with a PDZ-binding motif...
March 14, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28306280/search-for-cosmic-ray-electron-and-positron-anisotropies-with-seven-years-of-fermi-large-area-telescope-data
#5
S Abdollahi, M Ackermann, M Ajello, A Albert, W B Atwood, L Baldini, G Barbiellini, R Bellazzini, E Bissaldi, E D Bloom, R Bonino, E Bottacini, T J Brandt, P Bruel, S Buson, M Caragiulo, E Cavazzuti, A Chekhtman, S Ciprini, F Costanza, A Cuoco, S Cutini, F D'Ammando, F de Palma, R Desiante, S W Digel, N Di Lalla, M Di Mauro, L Di Venere, B Donaggio, P S Drell, C Favuzzi, W B Focke, Y Fukazawa, S Funk, P Fusco, F Gargano, D Gasparrini, N Giglietto, F Giordano, M Giroletti, D Green, S Guiriec, A K Harding, T Jogler, G Jóhannesson, T Kamae, M Kuss, S Larsson, L Latronico, J Li, F Longo, F Loparco, P Lubrano, J D Magill, D Malyshev, A Manfreda, M N Mazziotta, M Meehan, P F Michelson, W Mitthumsiri, T Mizuno, A A Moiseev, M E Monzani, A Morselli, M Negro, E Nuss, T Ohsugi, N Omodei, D Paneque, J S Perkins, M Pesce-Rollins, F Piron, G Pivato, G Principe, S Rainò, R Rando, M Razzano, A Reimer, O Reimer, C Sgrò, D Simone, E J Siskind, F Spada, G Spandre, P Spinelli, A W Strong, H Tajima, J B Thayer, D F Torres, E Troja, J Vandenbroucke, G Zaharijas, S Zimmer
The Large Area Telescope on board the Fermi Gamma-ray Space Telescope has collected the largest ever sample of high-energy cosmic-ray electron and positron events since the beginning of its operation. Potential anisotropies in the arrival directions of cosmic-ray electrons or positrons could be a signature of the presence of nearby sources. We use almost seven years of data with energies above 42 GeV processed with the Pass 8 reconstruction. The present data sample can probe dipole anisotropies down to a level of 10^{-3}...
March 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28303708/the-assessment-of-the-ionizing-radiation-dose-received-by-patients-during-some-diagnostic-x-ray-examinations-carried-out-on-the-basis-of-the-working-procedures-in-the-health-care-entities
#6
Marcin Bekas, Elżbieta Waśniewska, Adam Wardziński, Kamil Wieprzowski
Background: X-ray examination is a popular and universally used injury and disease diagnostic method. A distinctive X ray examination feature is that it can be done quickly which is extremely important in case of the need for rapid diagnosis of patients in life threatening condition. Another advantage of the X-ray examinations is also relatively low cost of carry. However, X-ray examination involve adverse health effects. During the examination the patient is subjected to ionizing radiation that might have impact on his health...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28291917/rectal-dose-to-prostate-cancer-patients-treated-with-proton-therapy-with-or-without-rectal-spacer
#7
Heeteak Chung, Jerimy Polf, Shahed Badiyan, Matthew Biagioli, Daniel Fernandez, Kujtim Latifi, Richard Wilder, Minesh Mehta, Michael Chuong
The purpose of this study was to evaluate whether a spacer inserted in the prerectal space could reduce modeled rectal dose and toxicity rates for patients with prostate cancer treated in silico with pencil beam scanning (PBS) proton therapy. A total of 20 patients were included in this study who received photon therapy (12 with rectal spacer (DuraSeal™ gel) and 8 without). Two PBS treatment plans were retrospectively created for each patient using the following beam arrangements: (1) lateral-opposed (LAT) fields and (2) left and right anterior oblique (LAO/RAO) fields...
January 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28284101/relationship-between-14-c-meaib-uptake-and-amino-acid-transporter-family-gene-expression-levels-or-proliferative-activity-in-a-pilot-study-in-human-carcinoma-cells-comparison-with-3-h-methionine-uptake
#8
Shinya Kagawa, Ryuichi Nishii, Tatsuya Higashi, Hiroshi Yamauchi, Emi Ogawa, Hiroyuki Okudaira, Masato Kobayashi, Mitsuyoshi Yoshimoto, Naoto Shikano, Keiichi Kawai
INTRODUCTION: To clarify the difference between system A and L amino acid transport imaging in PET clinical imaging, we focused on the use of α-[N-methyl-(11)C]-methylaminoisobutyric acid ([(11)C]MeAIB), and compared it with [S-methyl-(11)C]-L-methionine ([(11)C]MET). The aim of this study was to assess the correlation of accumulation of these two radioactive amino acid analogs with expression of amino acid transporters and cell proliferative activity in carcinoma cells. METHODS: Amino acid uptake inhibitor studies were performed in four human carcinoma cells (epidermal carcinoma A431, colorectal carcinoma LS180, and lung carcinomas PC14/GL and H441/GL) using the radioisotope analogs [(3)H]MET and [(14)C]MeAIB...
January 26, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28279745/novel-algorithm-for-accelerated-electroanatomical-mapping-and-prediction-of-earliest-activation-of-focal-cardiac-arrhythmias-using-mathematical-optimization
#9
Tobias Weber, Hugo A Katus, Sebastian Sager, Eberhard P Scholz
BACKGROUND: Premature beats (PBs) are a common finding in patients suffering from structural heart disease, but they can also be present in healthy individuals. Catheter ablation represents a suitable therapeutic approach. However, the exact localization of the origin can be challenging, especially in cases of low PB burden during the procedure. OBJECTIVE: Based on the hypothesis that mathematical optimization would significantly accelerate the localization of earliest activation we developed an automated mapping algorithm...
March 6, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28279213/cardiovascular-risk-factors-are-major-determinants-of-thrombotic-risk-in-patients-with-the-lupus-anticoagulant
#10
Florian Posch, Johanna Gebhart, Jacob H Rand, Silvia Koder, Peter Quehenberger, Vittorio Pengo, Cihan Ay, Ingrid Pabinger
BACKGROUND: Patients with the lupus anticoagulant (LA) are at an increased risk of thrombotic events, which in turn increase the risk of death. Understanding the determinants of thrombotic risk in patients with LA may pave the way towards targeted thromboprophylaxis. In the Vienna Lupus Anticoagulant and Thrombosis Study (LATS), we systematically evaluate risk factors for thrombotic events in patients with LA. METHODS: We followed 150 patients (mean age: 41.3 years, female gender: n = 122 (81...
March 10, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28264410/youngest-representative-of-the-extinct-genus-i-microphorites-i-in-the-eocene-amber-of-france-diptera-dolichopodidae-microphorinae
#11
Simone Bramuzzo, André Nel
Prior to the present study, seven species of the fossil microphorine (Dolichopodidae s. lat.) genus Microphorites Hennig, 1971 have been described: Microphorites extinctus Hennig, 1971 (type species), M. oculeus Grimaldi & Cumming, 1999, and M. similis Grimaldi & Cumming, 1999 (all from the Early Cretaceous Lebanese amber), M. deploegi Nel et al., 2004 (from the Early Cretaceous of France), M. utrillensis Peñalver, 2008 (from the Early Cretaceous amber of Spain), M. magaliae Perrichot & Engel, 2014 (from the Late Cretaceous amber of France), M...
February 13, 2017: Zootaxa
https://www.readbyqxmd.com/read/28259696/comparison-of-strategies-for-catheter-ablation-of-focal-atrial-tachycardia-originating-near-the-his-bundle-region
#12
Evgeny Lyan, Mauro Toniolo, Alexey Tsyganov, Luca Rebellato, Alessandro Proclemer, Massimiliano Manfrin, Anatoly Nechepurenko, Alexandr Morozov, Ayan Abdrahmanov, Grigory Gromyko, Vitaly Lyashenko, Marina Yakovleva
BACKGROUND: Recent studies have suggested that para-Hisian atrial tachycardia (AT) can be successfully ablated from the right atrium (RA), left atrium (LA) or non-coronary cusp (NCC) in the aorta; however, the best approach remains unclear. OBJECTIVE: This study aimed to compare different approaches to radiofrequency catheter ablation (RFCA) of para-Hisian AT. METHODS: We retrospectively analyzed 68 consecutive patients (72% females, aged 61±13 years) treated with RFCA for this type of AT...
March 1, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28255712/purification-of-lat-containing-membranes-from-resting-and-activated-t-lymphocytes
#13
Claire Hivroz, Paola Larghi, Mabel Jouve, Laurence Ardouin
In T lymphocytes, the immune synapse is an active zone of vesicular traffic. Directional transport of vesicular receptors and signaling molecules from or to the immune synapse has been shown to play an important role in T-cell receptor (TCR) signal transduction. However, how vesicular trafficking is regulating the activation of T cells is still a burning question, and the characterization of these intracellular compartments remains the first step to understand this process. We describe herein a protocol, which combines a separation of membranes on flotation gradient with an affinity purification of Strep-tagged fusion transmembrane proteins with Strep-Tactin(®) resin, allowing the purification of membranes containing the Strep-tagged molecule of interest...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28255286/ocular-adnexal-reconstruction-for-cutaneous-periocular-malignancies
#14
REVIEW
Alison B Huggins, Michelle W Latting, Douglas P Marx, Joseph N Giacometti
Although the majority of lesions present in the periocular region are benign, periocular cutaneous malignancies are certainly not uncommon and must be considered. The management of nonmelanoma cutaneous malignancies is predominately surgical with Mohs micrographic surgery or excision with frozen sections. The approach to reconstruction of the resulting defects depends on the defect location and size. When able, it is preferable to close lesions directly or with the recruitment of adjacent tissue in an effort to preserve the inherent anatomy...
February 2017: Seminars in Plastic Surgery
https://www.readbyqxmd.com/read/28255284/clinical-evaluation-of-blepharoptosis-distinguishing-age-related-ptosis-from-masquerade-conditions
#15
REVIEW
Michelle W Latting, Alison B Huggins, Douglas P Marx, Joseph N Giacometti
Aponeurotic ptosis accounts for the majority of acquired ptosis encountered in clinical practice. Other types of ptosis include traumatic, mechanical, neurogenic, and myogenic. In addition to true ptosis, some patients present with pseudoptosis caused by globe dystopia, globe asymmetry, ocular misalignment, or retraction of the contralateral lid. It is particularly important for the clinician to rule out neurologic causes of ptosis such as dysfunction of the third cranial nerve, Horner's syndrome, and myasthenia gravis, as these conditions can be associated with significant systemic morbidity and mortality...
February 2017: Seminars in Plastic Surgery
https://www.readbyqxmd.com/read/28244491/new-evidence-for-non-canonical-hippo-signaling-in-cancer
#16
Jonathan Cooper, Filippo G Giancotti
The molecular mechanisms governing self-renewal and differentiation of the mammary epithelium are incompletely defined; a better understanding of the events implicated in the specification and expansion of luminal progenitors is of particular importance as many breast cancers originate from their transformation. Britschgi et al. found that, in addition to phosphorylating and inactivating YAP, LATS functions as a scaffold to facilitate estrogen receptor-α ubiquitylation by the E3 ligase CRL4 and consequently suppresses luminal progenitor specification and expansion...
February 28, 2017: Cell Research
https://www.readbyqxmd.com/read/28235866/rab11-fip3-regulation-of-lck-endosomal-traffic-controls-tcr-signal-transduction
#17
Jérôme Bouchet, Iratxe Del Río-Iñiguez, Elena Vázquez-Chávez, Rémi Lasserre, Sonia Agüera-González, Céline Cuche, Mary W McCaffrey, Vincenzo Di Bartolo, Andrés Alcover
The role of endosomes in receptor signal transduction is a long-standing question, which remains largely unanswered. The T cell Ag receptor and various components of its proximal signaling machinery are associated with distinct endosomal compartments, but how endosomal traffic affects T cell signaling remains ill-defined. In this article, we demonstrate in human T cells that the subcellular localization and function of the protein tyrosine kinase Lck depends on the Rab11 effector FIP3 (Rab11 family interacting protein-3)...
February 24, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28224735/genetic-risk-variants-for-social-anxiety
#18
Murray B Stein, Chia-Yen Chen, Sonia Jain, Kevin P Jensen, Feng He, Steven G Heeringa, Ronald C Kessler, Adam Maihofer, Matthew K Nock, Stephan Ripke, Xiaoying Sun, Michael L Thomas, Robert J Ursano, Jordan W Smoller, Joel Gelernter
Social anxiety is a neurobehavioral trait characterized by fear and reticence in social situations. Twin studies have shown that social anxiety has a heritable basis, shared with neuroticism and extraversion, but genetic studies have yet to demonstrate robust risk variants. We conducted genomewide association analysis (GWAS) of subjects within the Army Study To Assess Risk and Resilience in Servicemembers (Army STARRS) to (i) determine SNP-based heritability of social anxiety; (ii) discern genetic risk loci for social anxiety; and (iii) determine shared genetic risk with neuroticism and extraversion...
March 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28213493/development-of-the-critical-care-pharmacotherapy-trials-network
#19
Seth R Bauer, Prasad E Abraham, Jeffrey F Barletta, Gretchen M Brophy, Brian L Erstad, Jeffrey P Gonzales, Curtis E Haas, Robert MacLaren, Eric W Mueller, Keith M Olsen, Ishaq Lat
PURPOSE: The development of the Critical Care Pharmacotherapy Trials Network (CCPTN) as a model for practice-based pharmacotherapy research is described. SUMMARY: The CCPTN was formed in 2010 as a collaborative research network dedicated to scientific investigation in the field of critical care pharmacotherapy. The CCPTN organizational structure is consistent with many professional pharmacy and interdisciplinary organizations and organized into 3 primary domains: executive committee, working committees, and network membership...
March 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28211266/-non-febrile-syndromes-in-the-traveler-returning-from-tropical-regions-admitted-in-a-monographic-unit
#20
A Anula-Morales, B Martin-Giner, M Hernández-Cabrera, C Carranza-Rodríguez, E Pisos-Álamo, N Jaén-Sánchez, J L Pérez-Arellano
OBJECTIVE: The aim was to analyse those syndromes without fever in travellers who return from tropical regions evaluated at our Department of Infectology and Tropical Medicine. Clarifying these conditions intends to reach earlier diagnoses and, perhaps, to avoid the emergence and spread of imported diseases, as well as to establish appropriate preventive measures. METHODS: An observational descriptive transversal study was performed, selecting those patients who returned from tropical regions without fever (n = 281), amongst all travellers evaluated in our department between 1998 and 2013...
February 17, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
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