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https://www.readbyqxmd.com/read/28224735/genetic-risk-variants-for-social-anxiety
#1
Murray B Stein, Chia-Yen Chen, Sonia Jain, Kevin P Jensen, Feng He, Steven G Heeringa, Ronald C Kessler, Adam Maihofer, Matthew K Nock, Stephan Ripke, Xiaoying Sun, Michael L Thomas, Robert J Ursano, Jordan W Smoller, Joel Gelernter
Social anxiety is a neurobehavioral trait characterized by fear and reticence in social situations. Twin studies have shown that social anxiety has a heritable basis, shared with neuroticism and extraversion, but genetic studies have yet to demonstrate robust risk variants. We conducted genomewide association analysis (GWAS) of subjects within the Army Study To Assess Risk and Resilience in Servicemembers (Army STARRS) to (i) determine SNP-based heritability of social anxiety; (ii) discern genetic risk loci for social anxiety; and (iii) determine shared genetic risk with neuroticism and extraversion...
March 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28213493/development-of-the-critical-care-pharmacotherapy-trials-network
#2
Seth R Bauer, Prasad E Abraham, Jeffrey F Barletta, Gretchen M Brophy, Brian L Erstad, Jeffrey P Gonzales, Curtis E Haas, Robert MacLaren, Eric W Mueller, Keith M Olsen, Ishaq Lat
PURPOSE: The development of the Critical Care Pharmacotherapy Trials Network (CCPTN) as a model for practice-based pharmacotherapy research is described. SUMMARY: The CCPTN was formed in 2010 as a collaborative research network dedicated to scientific investigation in the field of critical care pharmacotherapy. The CCPTN organizational structure is consistent with many professional pharmacy and interdisciplinary organizations and organized into 3 primary domains: executive committee, working committees, and network membership...
March 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28211266/-non-febrile-syndromes-in-the-traveler-returning-from-tropical-regions-admitted-in-a-monographic-unit
#3
A Anula-Morales, B Martin-Giner, M Hernández-Cabrera, C Carranza-Rodríguez, E Pisos-Álamo, N Jaén-Sánchez, J L Pérez-Arellano
OBJECTIVE: The aim was to analyse those syndromes without fever in travellers who return from tropical regions evaluated at our Department of Infectology and Tropical Medicine. Clarifying these conditions intends to reach earlier diagnoses and, perhaps, to avoid the emergence and spread of imported diseases, as well as to establish appropriate preventive measures. METHODS: An observational descriptive transversal study was performed, selecting those patients who returned from tropical regions without fever (n = 281), amongst all travellers evaluated in our department between 1998 and 2013...
February 17, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/28209773/mannan-binding-lectin-a-serum-collectin-suppresses-t-cell-proliferation-via-direct-interaction-with-cell-surface-calreticulin-and-inhibition-of-proximal-t-cell-receptor-signaling
#4
Na Zhao, Jie Wu, Simin Xiong, Liyun Zhang, Xiao Lu, Shangliang Chen, Qifeng Wu, Hailan Wang, Ying Liu, Zhengliang Chen, Daming Zuo
Mannan binding lectin (MBL), initially described to activate the complement pathway, is also known to be involved in the pathogenesis of autoimmune diseases. We report a thus far unknown function of MBL as a suppressor of T-cell activation. MBL markedly inhibited T-cell proliferation induced by anti-CD3 and anti-CD28 antibodies. Moreover, the presence of MBL during T-cell priming interfered with proximal T-cell receptor signaling by decreasing phosphorylation of Lck, ZAP-70, and LAT. MBL bound to T cells through interaction between the collagen-like region of MBL and calreticulin (CRT) expressed on the T-cell surface...
February 16, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28207839/plasma-fibrin-d-dimer-and-the-risk-of-left-atrial-thrombus-a-systematic-review-and-meta-analysis
#5
Huaibin Wan, Shuang Wu, Yanmin Yang, Jun Zhu, Aidong Zhang, Yan Liang
BACKGROUND: Plasma fibrin d-dimer has been taken as a marker for thrombus. The aim of this study was to evaluate the relationship between d-dimer (DD) levels and left atrial spontaneous echo contrast (SEC)/left atrial thrombus (LAT). METHODS: We identified clinical studies by systematic search of MEDLINE and EMBASE databases up to Feb 2016. All observational studies that considered DD as a study factor and trans-esophageal echocardiography (TEE) identified SEC/LAT as an outcome were included...
2017: PloS One
https://www.readbyqxmd.com/read/28199040/isotopic-half-life-and-enrichment-factor-in-two-species-of-european-freshwater-fish-larvae-an-experimental-approach
#6
Adrien Latli, Nicolas Sturaro, Nelson Desjardin, Loïc N Michel, William Otjacques, Gilles Lepoint, Patrick Kestemont
RATIONALE: Stable isotope ratios of carbon and nitrogen are valuable tools for field ecologists to use to analyse animal diets. However, the application of these tools requires knowledge of the tissue enrichment factor (TEF) and half-life (HL). We experimentally compared TEF and HL in 2 freshwater fish larvae. We hypothesised that chub had a better growth/tissue replacement ratio than roach, due to the use of a food closer to their natural diet. METHODS: We determined the isotopic HL, the TEF and the contribution of growth or metabolic tissue replacement to dynamic isotopic incorporation...
February 15, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28197890/relationships-among-diet-physical-activity-and-dual-plane-dual-energy-x-ray-absorptiometry-bone-outcomes-in-pre-pubertalgirls
#7
Jie Ren, Lynn S Brann, Kay S Bruening, Tamara A Scerpella, Jodi N Dowthwaite
: In pre-pubertal girls, nutrient intakes and non-aquatic organized activity were evaluated as factors in vertebral body bone mass, structure, and strength. Activity, vitamin B12, and dietary fiber predicted bone outcomes most consistently. Exercise and vitamin B12 appear beneficial, whereas high fiber intake appears to be adverse for vertebral body development. PURPOSE: Childhood development sets the baseline for adult fracture risk. Most studies evaluate development using postero-anterior (PA) dual-energy X-ray absorptiometry (DXA) areal bone mineral density, bone mineral content, and bone mineral apparent density...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28193661/determining-the-clinical-utility-of-an-absolute-procalcitonin-value-for-predicting-a-positive-culture-result
#8
Erica M Caffarini, Joshua DeMott, Gourang Patel, Ishaq Lat
Various procalcitonin ranges have been established to guide antimicrobial therapy; however, there are no data that establish whether the initial procalcitonin value will determine the likelihood of a positive culture result. This study aims to establish if the initial procalcitonin value on clinical presentation can provide positive predictive value of any positive culture result.This was a retrospective study of 813 medical intensive care unit patients. Data points collected included patient demographics, procalcitonin assays, source of infection, culture results, and length of stay...
February 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28183853/mark4-inhibits-hippo-signaling-to-promote-proliferation-and-migration-of-breast-cancer-cells
#9
Emad Heidary Arash, Ahmed Shiban, Siyuan Song, Liliana Attisano
The Hippo pathway is a critical regulator of tissue size, and aberrations in pathway regulation lead to cancer. MST1/2 and LATS1/2 kinases comprise the core of the pathway that, in association with adaptor proteins SAV and MOB, functions in a sequential manner to phosphorylate and inhibit the transcription factors YAP and TAZ. Here we identify mammalian MARK family members as activators of YAP/TAZ. We show that depletion of MARK4 in MDA-MB-231 breast cancer cells results in the loss of nuclear YAP/TAZ and decreases the expression of YAP/TAZ targets...
February 9, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28167254/seroprevalence-and-potential-risk-factors-of-t-gondii-infection-in-pregnant-women-attending-antenatal-care-at-bonga-hospital-southwestern-ethiopia
#10
Jalel Negero, Moti Yohannes, Kifle Woldemichael, Dechassa Tegegne
OBJECTIVES: To determine the seroprevalence and associated risk factors of T.gondii infection in pregnant women attending antenatal care at Bonga Hospital, Southwestern Ethiopia. METHODS: A cross-sectional study was carried out from February to May 2016. Systematic sampling technique was used to collect sera from 210 pregnant women. Sample was tested for anti-T. gondii antibodies by Latex Agglutination Test (LAT). Risk factors associated with T.gondii infection in pregnant women was assessed through structured questionnaire...
February 3, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28146109/the%C3%A2-characteristics%C3%A2-of%C3%A2-herpes%C3%A2-simplex%C3%A2-virus%C3%A2-type%C3%A2-1-infection%C3%A2-in%C3%A2-rhesus%C3%A2-macaques%C3%A2-and%C3%A2-the%C3%A2-associated-pathological%C3%A2-features
#11
Shengtao Fan, Hongzhi Cai, Xingli Xu, Min Feng, Lichun Wang, Yun Liao, Ying Zhang, Zhanlong He, Fengmei Yang, Wenhai Yu, Jingjing Wang, Jumin Zhou, Qihan Li
As one of the major pathogens for human herpetic diseases, herpes simplex virus type 1 (HSV1) causes herpes labialis, genital herpes and herpetic encephalitis. Our aim here was to investigate the infectious process of HSV1 in rhesus macaques and the pathological features induced during this infection. Clinical symptoms that manifested in the rhesus macaque during HSV1 infection included vesicular lesions and their pathological features. Viral distribution in the nervous tissues and associated pathologic changes indicated the typical systematic pathological processes associated with viral distribution of HSV1...
January 30, 2017: Viruses
https://www.readbyqxmd.com/read/28144396/novel-therapeutic-approaches-targeting-l-type-amino-acid-transporters-for-cancer-treatment
#12
REVIEW
Keitaro Hayashi, Naohiko Anzai
L-type amino acid transporters (LATs) mainly assist the uptake of neutral amino acids into cells. Four LATs (LAT1, LAT2, LAT3 and LAT4) have so far been identified. LAT1 (SLC7A5) has been attracting much attention in the field of cancer research since it is commonly up-regulated in various cancers. Basic research has made it increasingly clear that LAT1 plays a predominant role in malignancy. The functional significance of LAT1 in cancer and the potential therapeutic application of the features of LAT1 to cancer management are described in this review...
January 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28138396/how-much-will-older-adults-exercise-a-feasibility-study-of-aerobic-training-combined-with-resistance-training
#13
Ryan S Falck, Jennifer C Davis, Elizabeth Milosevic, Teresa Liu-Ambrose
BACKGROUND: Both aerobic training (AT) and resistance training (RT) have multidimensional health benefits for older adults including increased life expectancy and decreased risk of chronic diseases. However, the volume (i.e., frequency*time) of AT combined with RT in which untrained older adults can feasibly and safely participate remains unclear. Thus, our primary objective was to investigate the feasibility and safety of a high-volume exercise program consisting of twice weekly AT combined with twice weekly RT (i...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28128737/taz-is-an-independent-prognostic-factor-in-non-small-cell-lung-carcinoma-elucidation-at-protein-level
#14
Showkat A Malik, Mosin S Khan, Majeed Dar, Mahboob Ul Hussain, Syed Mudassar
BACKGROUND: Hippo-LATS pathway is involved in regulating multiple phenotypes. TAZ (transcriptional co-activator with PDZ-binding motif) is a prominent proto-oncogene of this developmental pathway. Elevated TAZ expression has been observed in many cancers including Non-Small Cell lung cancer (NSCLC). OBJECTIVE: We elucidated the frequency of protein expression of TAZ gene in NSCLC patients of our population along with its relationship with clinicopathological parameters and determined its prognostic significance concerning survival in patients with resected tumor...
January 20, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28118310/ratings-of-perceived-exertion-during-acute-resistance-exercise-performed-at-imposed-and-self-selected-loads-in-recreationally-trained-women
#15
Joshua A Cotter, Matthew J Garver, Taylor K Dinyer, Ciaran M Fairman, Brian C Focht
Resistance exercise (RE) is commonly employed to elicit skeletal muscle adaptation. Relative intensity of a training load links closely with the outcomes of regular RE. This study examined the RPE responses to acute bouts of RE using imposed (40% and 70% of 1RM) and self-selected loads (SS) in recreationally trained women. Twenty physically active women (23.15 ±2.92 yrs.) who reported regular RE training of at least three weekly sessions for the past year, volunteered to participate. During the initial visit, participants completed one repetition maximum (1RM) testing on four exercises in the following order: leg extension, chest press, leg curl, and lat pull-down...
January 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28114571/effect-of-corneal-nerve-ablation-on-immune-tolerance-induced-by-corneal-allografts-oral-immunization-or-anterior-chamber-injection-of-antigens
#16
Juan Mo, Sudha Neelam, Jessamee Mellon, Joseph R Brown, Jerry Y Niederkorn
Purpose: Severing corneal nerves during corneal transplantation does not affect first corneal transplants, but abolishes immune privilege of subsequent corneal allografts. This abrogation of immune privilege is attributable to the disabling of T regulatory cells (T regs) induced by corneal transplantation. The goal of this study was to determine if severing corneal nerves induces the development of contrasuppressor (CS) cells, which disable T regs that impair other forms of immune tolerance...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28106460/fermi-large-area-telescope-as-a-galactic-supernovae-axionscope
#17
M Meyer, M Giannotti, A Mirizzi, J Conrad, M A Sánchez-Conde
In a Galactic core-collapse supernova (SN), axionlike particles (ALPs) could be emitted via the Primakoff process and eventually convert into γ rays in the magnetic field of the Milky Way. From a data-driven sensitivity estimate, we find that, for a SN exploding in our Galaxy, the Fermi Large Area Telescope (LAT) would be able to explore the photon-ALP coupling down to g_{aγ}≃2×10^{-13}  GeV^{-1} for an ALP mass m_{a}≲10^{-9}  eV. These values are out of reach of next generation laboratory experiments...
January 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28103800/chmob2-binds-to-chcbk1-and-promotes-virulence-and-conidiation-of-the-fungal-pathogen-colletotrichum-higginsianum
#18
Johannes Schmidpeter, Marlis Dahl, Jörg Hofmann, Christian Koch
BACKGROUND: Mob family proteins are conserved between animals, plants and fungi and are essential for the activation of NDR kinases that control crucial cellular processes like cytokinesis, proliferation and morphology. RESULTS: We identified a hypomorphic allele of ChMOB2 in a random insertional mutant (vir-88) of the hemibiotrophic ascomycete fungus Colletotrichum higginsianum. The mutant is impaired in conidiation, host penetration and virulence on Arabidopsis thaliana...
January 19, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28086908/hiv-integration-sites-in-latently-infected-cell-lines-evidence-of-ongoing-replication
#19
Jori Symons, Abha Chopra, Eva Malantinkova, Ward De Spiegelaere, Shay Leary, Don Cooper, Chike O Abana, Ajantha Rhodes, Simin D Rezaei, Linos Vandekerckhove, Simon Mallal, Sharon R Lewin, Paul U Cameron
BACKGROUND: Assessing the location and frequency of HIV integration sites in latently infected cells can potentially inform our understanding of how HIV persists during combination antiretroviral therapy. We developed a novel high throughput sequencing method to evaluate HIV integration sites in latently infected cell lines to determine whether there was virus replication or clonal expansion in these cell lines observed as multiple integration events at the same position. RESULTS: We modified a previously reported method using random DNA shearing and PCR to allow for high throughput robotic processing to identify the site and frequency of HIV integration in latently infected cell lines...
January 13, 2017: Retrovirology
https://www.readbyqxmd.com/read/28068668/the-hippo-kinases-lats1-and-2-control-human-breast-cell-fate-via-crosstalk-with-er%C3%AE
#20
Adrian Britschgi, Stephan Duss, Sungeun Kim, Joana Pinto Couto, Heike Brinkhaus, Shany Koren, Duvini De Silva, Kirsten D Mertz, Daniela Kaup, Zsuzsanna Varga, Hans Voshol, Alexandra Vissieres, Cedric Leroy, Tim Roloff, Michael B Stadler, Christina H Scheel, Loren J Miraglia, Anthony P Orth, Ghislain M C Bonamy, Venkateshwar A Reddy, Mohamed Bentires-Alj
Cell fate perturbations underlie many human diseases, including breast cancer. Unfortunately, the mechanisms by which breast cell fate are regulated are largely unknown. The mammary gland epithelium consists of differentiated luminal epithelial and basal myoepithelial cells, as well as undifferentiated stem cells and more restricted progenitors. Breast cancer originates from this epithelium, but the molecular mechanisms that underlie breast epithelial hierarchy remain ill-defined. Here, we use a high-content confocal image-based short hairpin RNA screen to identify tumour suppressors that regulate breast cell fate in primary human breast epithelial cells...
January 26, 2017: Nature
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