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https://www.readbyqxmd.com/read/27903375/-in-vivo-and-in-vitro-effects-of-cd137-stimulation-on-vascular-calcification-in-high-fat-diet-fed-apoe-mice
#1
Y Chen, J C Yan, J Y Weng, Z Q Wang, C P Wang, C Shao
Objective: To investigate the effect and related mechanism of CD137 stimulation on aortic atherosclerotic plaque calcification in high fat diet fed ApoE(-/-) mice and on calcification of vascular smooth muscle cells (VSMCs). Methods: (1) ApoE(-/-) mice fed with high fat diet were randomly divided into 3 groups: CD137 activated group (treated by 200 μg CD137 agonist i. p. once per week for 6 weeks, n=5); CD137 inhibited group (anti-CD137 group: 200 μg anti-CD137 antibody + 200 μg CD137 agonist, i. p., once per week for 6 weeks, n=5) and control group (n=5)...
October 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/27898317/ammonia-tolerant-inocula-provide-a-good-base-for-anaerobic-digestion-of-microalgae-in-third-generation-biogas-process
#2
Ahmed Mahdy, Ioannis A Fotidis, Enrico Mancini, Mercedes Ballesteros, Cristina González-Fernández, Irini Angelidaki
This study investigated the ability of an ammonia-acclimatized inoculum to digest efficiently protein-rich microalgae for continuous 3rd generation biogas production. Moreover, we investigated whether increased C/N ratio could alleviate ammonia toxicity. The biochemical methane potential (BMP) of five different algae (Chlorella vulgaris)/manure (cattle) mixtures showed that the mixture of 80/20 (on VS basis) resulted in the highest BMP value (431mLCH4 gVS(-1)), while the BMP of microalgae alone (100/0) was 415mLCH4 gVS(-1)...
November 23, 2016: Bioresource Technology
https://www.readbyqxmd.com/read/27882147/molecular-profiling-of-a-simple-rat-model-of-open-tibial-fractures-with-hematoma-and-periosteum-disruption
#3
Jose Rafael Villafan-Bernal, Lorenzo Franco-De La Torre, Ana Soledad Sandoval-Rodriguez, Juan Armendariz-Borunda, Juan Luis Alcala-Zermeno, Jose Alfonso Cruz-Ramos, Gabriela Lopez-Armas, Blanca Estela Ramirez-Bastidas, Gracia Viviana González-Enríquez, Emerson Armando Collazo-Guzman, Raigam Jafet Martinez-Portilla, Sergio Sánchez-Enríquez
Bone fractures are a worldwide public health concern. Therefore, improving understanding of the bone healing process at a molecular level, which could lead to the discovery of potential therapeutic targets, is important. In the present study, a model of open tibial fractures with hematoma disruption, periosteal rupture and internal fixation in 6-month-old male Wistar rats was established, in order to identify expression patterns of key genes and their protein products throughout the bone healing process. A tibial shaft fracture was produced using the three-point bending technique, the hematoma was drained through a 4-mm incision on the medial aspect of the tibia and the fracture stabilized by inserting a needle into the medullary canal...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882108/effects-of-piezosurgery-in-accelerating-the-movement-of-orthodontic-alveolar-bone-tooth-of-rats-and-the-expression-mechanism-of-bmp-2
#4
Jinyou Han, Hong He
The aim of the study was to investigate the effects of piezosurgery in accelerating the movement of orthodontic alveolar bone tooth of rats and the expression mechanism of bone morphogenetic protein-2 (BMP-2). Adult male Wistar rats (n=30), with an age range of 14-15 weeks, and an average weight of 250±16 g were used. The animals were randomly divided into the control and observation groups. The rats in the control group were injected with 25-dihydroxyvitamin (1,25-dihydroxycholecalciferol) into their dental ligament...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27862226/histone-h4-methyltransferase-suv420h2-maintains-fidelity-of-osteoblast-differentiation
#5
Khani Farzaneh, Roman Thaler, Christopher R Paradise, David R Deyle, Marianne Kruijthof-de Julio, Mario Galindo, Jonathan A Gordon, Gary S Stein, Amel Dudakovic, Andre J van Wijnen
Osteogenic lineage commitment and progression is controlled by multiple signaling pathways (e.g., WNT, BMP, FGF) that converge on bone-related transcription factors. Access of osteogenic transcription factors to chromatin is controlled by epigenetic regulators that generate post-translational modifications of histones ("histone code"), as well as read, edit and/or erase these modifications. Our understanding of the biological role of epigenetic regulators in osteoblast differentiation remains limited. Therefore, we performed next-generation RNA sequencing (RNA-seq) and established which chromatin-related proteins are robustly expressed in mouse bone tissues (e...
November 9, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27848974/differential-expression-of-tgf-%C3%AE-superfamily-members-and-role-of-smad1-5-9-signalling-in-chondral-versus-endochondral-chondrocyte-differentiation
#6
Verena Dexheimer, Jessica Gabler, Katharina Bomans, Tanja Sims, Georg Omlor, Wiltrud Richter
Proteins of the transforming-growth-factor-β (TGF-β)-superfamily have a remarkable ability to induce cartilage and bone and the crosstalk of TGF-β - and BMP-signalling pathways appears crucial during chondrocyte development. Aim was to assess the regulation of TGF-β-superfamily members and of Smad2/3- and Smad1/5/9-signalling during endochondral in vitro chondrogenesis of mesenchymal stromal cells (MSC) relative to chondral redifferentiation of articular chondrocytes (AC) to adjust chondrocyte development of MSC towards a less hypertrophic phenotype...
November 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27843679/high-neurological-complication-rates-for-extreme-lateral-lumbar-interbody-fusion-and-related-techniques-a-review-of-safety-concerns
#7
Nancy E Epstein
BACKGROUND: There are frequent reports of lumbosacral plexus and other neurological injuries occurring with extreme lateral interbody fusions (XLIF) and other related lateral lumbar techniques. METHODS: This review focuses on the new neurological deficits (e.g. lumbosacral plexus, root injuries) that occur following minimally invasive surgery (MIS) XLIF and other related lateral lumbar techniques. RESULTS: A review of multiple articles revealed the following ranges of new postoperative neurological complications for XLIF procedures: plexus injuries 13...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27843458/expression-of-bmp-and-actin-membrane-bound-inhibitor-is-increased-during-terminal-differentiation-of-mscs
#8
Christian G Pfeifer, Alexandra Karl, Arne Berner, Johannes Zellner, Paul Schmitz, Markus Loibl, Matthias Koch, Peter Angele, Michael Nerlich, Michael B Mueller
Chondrogenic differentiating mesenchymal stem cells (MSCs) are mimicking embryonal endochondral ossification and become hypertrophic. BMP (bone morphogenetic protein) and Activin Membrane Bound Inhibitor (BAMBI) is a pseudoreceptor that regulates the activity of transforming growth factor-β (TGF-β) and BMP signalling during chondrogenesis. Both TGF-β and BMP signalling are regulators of chondrogenic cell differentiation. Human bone marrow derived MSCs were chondrogenically predifferentiated in aggregate culture for 14 days...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27843223/treatment-of-atrophic-femoral-non-unions-according-to-the-diamond-concept-results-of-one-and-two-step-surgical-procedure
#9
Arash Moghaddam, Benjamin Thaler, Thomas Bruckner, Michael Tanner, Gerhard Schmidmaier
BACKGROUND: The treatment of non-unions in long bones poses a great challenge, particularly in cases of infection or large osseous defects. This article evaluates the use of the diamond concept in the treatment of femoral non-unions in a one-step or two-step procedure according to the Masquelet technique. PATIENTS AND METHODS: Between February 2010 and March 2014, 88 patients with atrophic femoral non-unions were included in our study. The treatment was performed in one step (Group G1) on 41 patients and in two-step Masquelet technique (Group G2) on 47 patients, according to the diamond concept...
March 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/27842921/suppression-of-osteoblast-related-genes-during-osteogenic-differentiation-of-adipose-tissue-derived-stromal-cells
#10
Yahya Açil, Amir Alexander Ghoniem, Aydin Gülses, Tobias Kisch, Felix Stang, Jörg Wiltfang, Matthias Gierloff
Recent studies indicated a lower osteogenic differentiation potential of adipose tissue-derived stromal cells (ASCs) compared to bone marrow derived mesenchymal stromal cells. The aim of this study was to evaluate the effects of potent combinations of highly osteogenic bone morphogenetic proteins (BMPs) in order to enhance the osteogenic differentiation potential of ASCs. Human ASCs were cultured for 10 days in the presence of osteogenic medium consisting of dexamethasone, ß-glycerophosphate and ascorbat-2-phosphate (OM) supplemented with BMP-2, BMP-6, BMP-9+IGF-2 and BMP-2,-6,-9 (day 1+2: 50 ng/ml, days 3-6: 100 ng/ml, days 7-10: 200 ng/ml)...
October 18, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27829744/bone-morphogenetic-proteins-signaling-periodontal-bone-regeneration-and-repair
#11
REVIEW
G Sai Anusuya, M Kandasamy, S A Jacob Raja, S Sabarinathan, P Ravishankar, Balu Kandhasamy
Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. Originally discovered by their ability to induce the formation of bone and cartilage, BMPs are now considered to constitute a group of pivotal morphogenetic signals, orchestrating tissue architecture throughout the body. The important functioning of BMP signals in physiology is emphasized by the multitude of roles for dysregulated BMP signaling in pathological processes. A study done wherein it was found that protein extracts from bone implanted into the animals at nonbone sites induced the formation of new cartilage and bone tissue...
October 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/27822590/do-osteoporotic-fractures-constitute-a-greater-recalcitrant-challenge-for-skeletal-regeneration-investigating-the-efficacy-of-bmp-7-and-zoledronate-treatment-of-diaphyseal-fractures-in-an-open-fracture-osteoporotic-rat-model
#12
N Mathavan, M Tägil, H Isaksson
: Osteoporotic fractures may pose a challenge for skeletal regeneration. This study investigates if pharmaceutical interventions such as bone morphogenetic protein 7 (BMP-7) alone or in combination with Zoledronate have equivalent efficacy in osteoporotic bone? Our findings suggest they do and that an osteoporotic bone environment may increase sensitivity to BMP-7. INTRODUCTION: Osteoporosis is thought to contribute to delayed or impaired bone healing. Bone morphogenetic protein 7 (BMP-7) alone or synergistically combined with zoledronate (ZA) has proven effective in augmenting the regenerative response in healthy young male rats...
November 7, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27815469/effect-of-bmp2-platelet-rich-plasma-biphasic-calcium-phosphate-scaffold-on-accelerated-osteogenesis-in-mastoid-obliteration
#13
Chul Ho Jang, Cheol Hee Choi, Yong Beom Cho
The aim of this study was to evaluate the synergistic effect of platelet-rich plasma (PRP) and recombinant human bone morphogenic protein (BMP)-2 on accelerated osteogenesis of hydroxyapatite/β-tricalcium phosphate mixture and biphasic calcium phosphate (BCP) in mastoid obliteration. To the best of our knowledge, there have been no studies reporting the enhancing effects of BCP, combined with BMP2 and PRP, on osteogenesis in mastoid obliteration. Mastoid obliteration was performed in a control group (BCP only, n=7), a group treated with BMP2 and BCP (experimental group I, n=7), and a group treated with BMP2, PRP and BCP (experimental group II, n=7)...
November 2016: In Vivo
https://www.readbyqxmd.com/read/27815159/expression-and-functional-role-of-bone-morphogenetic-proteins-bmps-in-cyclical-corpus-luteum-in-buffalo-bubalus-bubalis
#14
G Rajesh, Avishek Paul, S R Mishra, Jaya Bharati, Nipuna Thakur, Tanmay Mondal, Sanjhali Soren, S Harikumar, K Narayanan, V S Chouhan, Sadhan Bag, B C Das, G Singh, V P Maurya, G Taru Sharma, Mihir Sarkar
The role of growth factors in the modulation of ovarian function is an interesting area of research in reproductive biology. Recently, we have shown the expression and role of IGF, EGF, VEGF and FGF in the follicle and CL. Here, we report the presence of Bone Morphogenetic Proteins (BMPs) and their functional receptors in the corpus luteum (CL) of buffalo. The bubaline CL was classified into four stages according to the morphology and progesterone (P4) concentration. The qPCR, immunoblot and immunohistochemistry studies revealed that BMP2 and BMP Receptors (BMPR1A, BMPR1B and BMPR2) were significantly upregulated during the mid stage whereas BMP4 and BMP7 were upregulated during the early stage of CL (P<0...
January 1, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/27811472/fraction-of-auxemma-oncocalyx-and-oncocalyxone-a-affects-the-in-vitro-survival-and-development-of-caprine-preantral-follicles-enclosed-in-ovarian-cortical-tissue
#15
Johanna Leiva-Revilla, Laritza Ferreira Lima, Simone Vieira Castro, Claudio Cabral Campello, Valdevane Rocha Araújo, Juliana Jales de Hollanda Celestino, Otília Deusdênia Loiola Pessoa, Edilberto Rocha Silveira, Ana Paula Ribeiro Rodrigues, José Ricardo Figueiredo
BACKGROUND: Auxemma oncocalyx and its main component oncocalyxone A (onco A) have a high level of antioxidant and antitumor activity, but there are no studies on the action of both of these drugs regarding folliculogenesis. MATERIAL AND METHODS: Caprine ovarian tissue fragments were fixed (non-cultured control) or cultured for 1 or 7 days in α-MEM+ alone (cultured control) or supplemented with dimethyl sulfoxide (DMSO; 20% v/v), bone morphogenetic protein 15 (BMP-15; 100 ng/ml), doxorubicin (DXR; 0...
2016: Forschende Komplementärmedizin, Research in Complementary Medicine
https://www.readbyqxmd.com/read/27800217/increased-osteoinductivity-and-mineralization-by-minimal-concentration-of-bone-morphogenetic-protein-2-loaded-onto-biphasic-calcium-phosphate-in-a-rabbit-sinus
#16
Jae-Shin Kim, Jae-Kook Cha, Jung-Seok Lee, Seong-Ho Choi, Kyoo-Sung Cho
PURPOSE: The purpose of the present study was to evaluate the effectiveness of a minimal concentration of bone morphogenetic protein-2 (BMP-2) in terms of quantitative and qualitative analyses of newly formed bone in a rabbit maxillary sinus model. METHODS: In 7 rabbits, sinus windows were prepared bilaterally. Biphasic calcium phosphate (BCP) loaded with 0.05 mg/mL BMP-2 was grafted into one sinus (the BMP group) and saline-soaked BCP was placed into the other (the control group) in each animal...
October 2016: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/27788382/dentine-pulp-tissue-engineering-in-miniature-swine-teeth-by-set-calcium-silicate-containing-bioactive-molecules
#17
Dimitrios Tziafas, Konstantinos Kodonas, Christos Gogos, Christina Tziafa, Seraphim Papadimitriou
OBJECTIVE: The present study aims to investigate whether reparative dentinogenesis could be guided at central pulpal sites or at a distance from the amputated pulp of miniature pig teeth, by using set calcium silicate-based carriers containing human recombinant bioactive molecules. DESIGN: Pulp exposures were performed in 72 permanent teeth of 4 healthy miniature swine. The teeth were capped with pre-manufactured implants of set calcium silicate-based material containing BMP-7, TGFβ1 or WnT-1, for 3 weeks...
January 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/27785631/odontogenic-differentiation-and-biomineralization-potential-of-dental-pulp-stem-cells-inside-mg-based-bioceramic-scaffolds-under-low-level-laser-treatment
#18
Anna Theocharidou, Athina Bakopoulou, Eleana Kontonasaki, Eleni Papachristou, Christina Hadjichristou, Maria Bousnaki, George Theodorou, Lambrini Papadopoulou, Nikolaos Kantiranis, Konstantinos Paraskevopoulos, Petros Koidis
This study aimed to investigate the potential of low-level laser irradiation (LLLI) to promote odontogenic differentiation and biomineralization by dental pulp stem cells (DPSCs) seeded inside bioceramic scaffolds. Mg-based, Zn-doped bioceramic scaffolds, synthesized by the sol-gel technique, were spotted with DPSCs and exposed to LLLI at 660 nm with maximum output power of 140 mw at fluencies (a) 2 and 4 J/cm(2) to evaluate cell viability/proliferation by the MTT assay and (b) 4 J/cm(2) to evaluate cell differentiation, using real-time PCR (expression of odontogenic markers) and a p-nitrophenylphosphate (pNPP)-based assay for alkaline phosphatase (ALP) activity measurement...
October 26, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27784668/muscle-as-an-osteoinductive-niche-for-local-bone-formation-with-the-use-of-a-biphasic-calcium-sulphate-hydroxyapatite-biomaterial
#19
D B Raina, A Gupta, M M Petersen, W Hettwer, M McNally, M Tägil, M-H Zheng, A Kumar, L Lidgren
OBJECTIVES: We have observed clinical cases where bone is formed in the overlaying muscle covering surgically created bone defects treated with a hydroxyapatite/calcium sulphate biomaterial. Our objective was to investigate the osteoinductive potential of the biomaterial and to determine if growth factors secreted from local bone cells induce osteoblastic differentiation of muscle cells. MATERIALS AND METHODS: We seeded mouse skeletal muscle cells C2C12 on the hydroxyapatite/calcium sulphate biomaterial and the phenotype of the cells was analysed...
October 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27779163/effects-of-roughly-focused-extracorporeal-shock-waves-therapy-on-the-expressions-of-bone-morphogenetic-protein-2-and-osteoprotegerin-in-osteoporotic-fracture-in-rats
#20
Hai-Ming Huang, Xiao-Lin Li, Shu-Qiang Tu, Xiao-Feng Chen, Chang-Chun Lu, Liang-Hua Jiang
BACKGROUND: Roughly focused extracorporeal shock waves therapy (ESWT) is characterized by a wide focal area, a large therapy zone, easy positioning, and less pain during treatment. The purpose of this study was to investigate the effects of roughly focused ESWT on the expression of osteoprotegerin (OPG) and bone morphogenetic protein-2 (BMP-2) in osteoporotic fractures in rats. METHODS: Seventy-two female Sprague-Dawley (SD) rats, 3 months old, were divided into sham-operated group (n = 6) and an ovariectomized (OVX) group (n = 66)...
2016: Chinese Medical Journal
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