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https://www.readbyqxmd.com/read/28637038/synergic-impact-of-vascular-calcification-and-low-autonomic-tone-in-mortality-of-hemodialysis-patients
#1
Hwee-Yeong Ng, Shu-Kai Hsueh, Yueh-Ting Lee, Terry Ting-Yu Chiou, Pei-Chen Huang, Chien-Te Lee
BACKGROUND: Both cardiovascular calcification and autonomic dysfunction are frequently encountered in hemodialysis patients. We aimed to investigate the relationship between cardiovascular calcification and heart rate variability (HRV) and their influence on long-term outcome. METHODS: Seventy-eight hemodialysis patients underwent echocardiogram and radiography of the pelvis and hands to identify valvular and vascular calcification. HRV was evaluated using a commercial machine...
June 22, 2017: Nephron
https://www.readbyqxmd.com/read/28632565/neuroforaminal-bone-growth-following-minimally-invasive-transforaminal-lumbar-interbody-fusion-with-bmp-a-computed-tomographic-analysis
#2
Junyoung Ahn, Anton Y Jorgensen, Daniel D Bohl, Ehsan Tabaraee, Vincent J Rossi, Khaled Aboushaala, Kern Singh
STUDY DESIGN: Computed tomographic analysis. OBJECTIVE: To identify radiographic patterns of symptomatic neuroforaminal bone growth (NFB) in patients who have undergone a single-level minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) augmented with bone morphogenetic proteins (BMP) utilizing computed tomography (CT). SUMMARY OF BACKGROUND DATA: BMP induces osteoblast differentiation leading to new bone formation. The association of BMP utilization and heterotopic bone formation after an MIS-TLIF has been described...
July 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28627680/bmp%C3%A2-7-suppresses-excessive-scar-formation-by-activating-the-bmp%C3%A2-7-smad1-5-8-signaling-pathway
#3
Jingdong Guo, Quan Lin, Ying Shao, Li Rong, Duo Zhang
Scarring is the inevitable consequence of wound repair, which may cause significant physical and mental pain to patients when excessive. Bone morphogenetic protein‑7 (BMP‑7) has been proved to inhibit TGF‑β‑induced fibrosis in various tissues including dermal papilla cells. However, the effect of BMP‑7 on hypertrophic scarring, a common proliferative disorder of dermal fibroblasts, has not been determined. To overcome this problem, the present study established a mouse model of thermal injury to investigate the inhibitory effects of BMP‑7 on scar formation...
June 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28600892/a-novel-free-ammonia-based-pretreatment-technology-to-enhance-anaerobic-methane-production-from-primary-sludge
#4
Wei Wei, Xu Zhou, Guo-Jun Xie, Haoran Duan, Qilin Wang
This study proposed a novel free ammonia (FA i.e. NH3 ) pretreatment technology to enhance anaerobic methane production from primary sludge for the first time. The solubilisation of primary sludge was substantially enhanced following 24 h FA pretreatment (250∼680 mg NH3 -N/L), by which the release of soluble chemical oxygen demand (SCOD) (i.e. 0.4 mg SCOD/mg VS added; VS: volatile solids) was approximately 10 times as much as that without pretreatment (i.e. 0.03 mg SCOD/mg VS added). Then, biochemical methane potential (BMP) tests demonstrated that FA pretreatment of 250∼680 mg NH3 -N/L was capable of enhancing anaerobic methane production while the digestion time was more than 7 days...
June 10, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28594136/extension-of-the-culture-period-for-the-in%C3%A2-vitro-growth-of-bovine-oocytes-in-the-presence-of-bone-morphogenetic-protein-4-increases-oocyte-diameter-but-impairs-subsequent-developmental-competence
#5
Yinghua Yang, Chihiro Kanno, Kenichiro Sakaguchi, Yojiro Yanagawa, Seiji Katagiri, Masashi Nagano
Bone morphogenetic protein-4 (BMP-4) inhibits luteinization of granulosa cells during in vitro growth (IVG) culture of bovine oocytes; however, oocytes derived from a 12 day IVG were less competent for development than in vivo-grown oocytes. We herein investigated whether an extended IVG culture with BMP-4 improves oocyte growth and development to blastocysts after in vitro fertilization. Oocyte-granulosa cell complexes (OGCs) were cultured for 14 or 16 days with BMP-4 (10 ng/mL), while a 12 day culture with BMP-4 served as the in vitro control...
June 8, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28584575/melanin-extract-from-gallus-gallus-domesticus-promotes-proliferation-and-differentiation-of-osteoblastic-mg-63-cells-via-bone-morphogenetic-protein-2-signaling
#6
Han-Seok Yoo, Kang-Hyun Chung, Kwon-Jai Lee, Dong-Hee Kim, Jeung Hee An
BACKGROUND/OBJECTIVES: Gallus gallus domesticus (GD) is a natural mutant breed of chicken in Korea with an atypical characterization of melanin in its tissue. This study investigated the effects of melanin extracts of GD on osteoblast differentiation and inhibition of osteoclast formation. MATERIALS/METHODS: The effects of the melanin extract of GD on human osteoblast MG-63 cell differentiation were examined by evaluating cell viability, osteoblast differentiation, and expression of osteoblast-specific transcription factors such as bone morphogenetic protein 2 (BMP-2), small mothers against decapentaplegic homologs 5 (SMAD5), runt-related transcription factor 2 (RUNX2), osteocalcin and type 1 collagen (COL-1) by reverse transcription-polymerase chain reaction and western blotting analysis...
June 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/28584091/dissecting-bmp-signaling-input-into-the-gene-regulatory-networks-driving-specification-of-the-blood-stem-cell-lineage
#7
Arif Kirmizitas, Stuart Meiklejohn, Aldo Ciau-Uitz, Rachel Stephenson, Roger Patient
Hematopoietic stem cells (HSCs) that sustain lifelong blood production are created during embryogenesis. They emerge from a specialized endothelial population, termed hemogenic endothelium (HE), located in the ventral wall of the dorsal aorta (DA). In Xenopus, we have been studying the gene regulatory networks (GRNs) required for the formation of HSCs, and critically found that the hemogenic potential is defined at an earlier time point when precursors to the DA express hematopoietic as well as endothelial genes, in the definitive hemangioblasts (DHs)...
June 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28578352/endogenous-parathyroid-hormone-promotes-fracture-healing-by-increasing-expression-of-bmpr2-through-camp-pka-creb-pathway-in-mice
#8
Wei Zhou, Lipeng Yu, Jin Fan, Bowen Wan, Tao Jiang, Jian Yin, Yao Huang, Qingqing Li, Guoyong Yin, Zhaoxing Hu
BACKGROUND/AIMS: Endogenous parathyroid hormone (PTH) plays an important role in fracture healing. This study investigated whether endogenous PTH regulates fracture healing by bone morphogenetic protein (BMP) and/or the transforming growth factor-β (TGF-β) signaling pathway. METHODS: Eight-week-old wild-type (WT) and PTH-knockout (PTH KO) male mice were selected, and models of open right-femoral fracture were constructed. Fracture healing and callus characteristics of mice in the two groups were compared by X-ray, micro-computed tomography, histological, and immunohistochemical examinations...
June 5, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28577100/the-content-of-multipotent-stromal-cells-in-3-4-5-month-heterotopic-bone-marrow-transplants-of-cba-mice-subjected-to-a-single-exposure-to-osteogenic-stimuli-curettage-bmp-2-or-antigens-s-typhimurium-antigenic-complex-lps
#9
Yu F Gorskaya, V G Nesterenko
At the early stages of development (3 months), transplants from bone marrow donors subjected to single in vivo stimulation (curettage, administration of BMP-2 or antigenic complex of S. typhimurium) 1 day before transplantation were characterized by significantly elevated content of nucleated cells (by 1.4, 1.9 and 2.9 times, respectively), efficiency of cloning of multipotent stromal cells (by 3.8, 3.8 and 7.2 times), and total number of multipotent stromal cells (by 5, 7 and 21 times) and osteogenic multipotent stromal cells (by 5, 9 and 15 times) in comparison with the control (intact donors); more rapid increase in the weight of bone capsules was also noted...
June 3, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28574217/primary-ridge-augmentation-with-collagenated-xenogenic-block-bone-substitute-in-combination-with-collagen-membrane-and-rhbmp-2-a-pilot-histological-investigation
#10
Goran I Benic, Myung-Jae Joo, So-Ra Yoon, Jae-Kook Cha, Ui-Won Jung
OBJECTIVE: The aim of this pilot study was to test whether a porcine collagenated bone substitute block (PCBB) and collagen membrane (CM) loaded with bone morphogenetic protein-2 (BMP-2) used for horizontal ridge augmentation differ from PCBB and CM without BMP-2 regarding the osseointegration of the grafting material and the maintenance of the ridge contour. MATERIAL AND METHODS: Two semi-saddle bone defects were created in each side of the mandible of six dogs...
June 2, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/28574123/orthogonal-plating-of-vancouver-b1-and-c-type-periprosthetic-femur-fracture-nonunions
#11
Christopher E Birch, Michael Blankstein, Jesse D Chlebeck, Craig S Bartlett Rd
BACKGROUND: Periprosthetic femoral shaft fractures are a significant complication after total hip arthroplasty (THA). Plate osteosynthesis has been the mainstay of treatment around well-fixed stems. Nonunions are a rare and challenging complication of this fixation method. We report the outcomes of a novel orthogonal plating surgical technique for Vancouver B1 and C-type periprosthetic fractures that previously failed open reduction internal fixation (ORIF). METHODS: A retrospective review identified all patients with Vancouver B1/C THA periprosthetic femoral nonunions from 2010 to 2015...
May 27, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28566776/infected-nonunion-of-tibia
#12
Milind Madhav Chaudhary
Infected nonunions of tibia pose many challenges to the treating surgeon and the patient. Challenges include recalcitrant infection, complex deformities, sclerotic bone ends, large bone gaps, shortening, and joint stiffness. They are easy to diagnose and difficult to treat. The ASAMI classification helps decide treatment. The nonunion severity score proposed by Calori measures many parameters to give a prognosis. The infection severity score uses simple clinical signs to grade severity of infection. This determines number of surgeries and allows choice of hardware, either external or internal for definitive treatment...
May 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28560399/microrna-expression-analysis-during-fk506-induced-osteogenic-differentiation-in-rat-bone-marrow-stromal-cells
#13
Jing Zhang, Xiaoping Yu, Youcheng Yu, Yiming Gong
FK506 (also known as tacrolimus) is a potent immunosuppressive agent that is widely used in the treatment of graft-rejection and autoimmune diseases. FK506 has attracted additional attention owing to its potential role in osteogenic differentiation and bone formation. MicroRNAs (miRNAs) have been demonstrated to serve important roles in the regulation of osteogenic differentiation; however, identification of specific miRNAs and their roles in regulating FK506‑induced osteogenic differentiation have been poorly examined...
July 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28548630/tenogenic-differentiation-of-human-embryonic-stem-cells
#14
Tina P Dale, Shazia Mazher, William R Webb, Jing Zhou, Nicola Maffulli, G-Q Chen, Alicia J El Haj, Nicholas R Forsyth
Tendon healing is complex to manage because of the limited regeneration capacity of tendon tissue; stem cell-based tissue engineering approaches may provide alternative healing strategies. We sought to determine whether human embryonic stem cells (hESC) could be induced to differentiate into tendon-like cells by the addition of exogenous bone morphogenetic protein (BMP)12 (growth differentiation factor(GDF)7) and BMP13 (GDF6). hESC (SHEF-1) were maintained with or without BMP12/13 supplementation, or supplemented with BMP12/13 and the SMAD signalling cascade blocking agent, dorsomorphin...
May 26, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28537650/tendon-healing-induced-by-chemically-modified-mrnas
#15
K Groth, T Berezhanskyy, M K Aneja, J Geiger, M Schweizer, L Maucksch, T Pasewald, T Brill, B Tigani, E Weber, C Rudolph, G Hasenpusch
Tendon disorders are frequent both in human and veterinary medicine with high re-injury rates and unsatisfactory therapeutic treatments. Application of naked, chemically-modified mRNA (cmRNA), encoding for therapeutic proteins, is an innovative approach to address tendon healing. In the current study, we demonstrated that injection of naked cmRNA, diluted in a glucose-containing solution, into tendons resulted in high protein expression in healthy and experimentally-injured tendons. Injection of bone morphogenetic protein 7 (BMP-7)-encoding cmRNA resulted in a significantly higher expression of BMP-7 protein and reduced formation of collagen type III, compared to vehicle control...
May 24, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/28535613/expression-and-purification-of-biologically-active-human-bone-morphogenetic-protein-4-in-recombinant-chinese-hamster-ovary-cells
#16
Minyub Cha, Nara Han, Jia Pi, Yongsu Jeong, Kwanghee Baek, Jaeseung Yoon
Bone morphogenetic protein-4 (BMP-4) is considered to have therapeutic potential for various diseases including cancers; however, the high expression of biologically active recombinant human BMP-4 (rhBMP-4) needed to manufacture rhBMP-4 for therapeutic purposes has yet to be established. In the current study, we established a recombinant Chinese hamster ovary (rCHO) cell line overexpressing rhBMP-4 as well as a production process using 7.5-l bioreactor (5 l working volume). The expression of the mature rhBMP-4 was significantly enhanced by recombinant furin expression...
May 24, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28527192/in-vitro-evaluation-of-an-injectable-biphasic-calcium-phosphate-bcp-carrier-system-combined-with-recombinant-human-bone-morphogenetic-protein-rhbmp-9
#17
Masako Fujioka-Kobayashi, Benoit Schaller, Yufeng Zhang, Benjamin E Pippenger, Richard J Miron
Bone morphogenetic protein 9 (BMP9) has previously been characterized as the strongest osteoinductive growth factor among the BMP family. The aim of the present study was to evaluate the possibility of combining rhBMP9 with an injectable biphasic calcium phosphate (I-BCP, maxresorb inject®), since I-BCP is an easy to handle biomaterial with ideal properties for bone augmentation procedures. The adsorption potential of rhBMP9 as well as the cell behavior of bone stromal ST2 cells were investigated on cell viability, adhesion, proliferation and osteogenic differentiation for I-BCP combined with/without rhBMP9 in vitro...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28496198/bone-forming-peptide-2-derived-from-bmp-7-enhances-osteoblast-differentiation-from-multipotent-bone-marrow-stromal-cells-and-bone-formation
#18
Hyung Keun Kim, Jun Sik Lee, Ji Hyun Kim, Jong Keun Seon, Kyung Soon Park, Myung Ho Jeong, Taek Rim Yoon
Strategies for efficient osteogenic differentiation and bone formation from stem cells would have clinical applications in treating nonunion fracture healing. Many researchers have attempted to develop adjuvants as specific stimulators of bone formation for therapeutic use in patients with bone resorption. Therefore, development of specific stimulators of bone formation has therapeutic significance in the treatment of osteoporosis. To date, investigations of the mature forms of bone morphogenetic proteins (BMPs) have focused on regulation of bone generation...
May 12, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28492349/a-novel-compressive-stress-based-osteoarthritis-like-chondrocyte-system
#19
In-Chi Young, Sung-Ting Chuang, Amit Gefen, Wei-Ting Kuo, Chun-Ting Yang, Chia-Hsien Hsu, Feng-Huei Lin
Mechanical stress damage and insufficient self-repair can contribute to osteoarthritis (OA) in the affected joint. As the effects of stress on chondrocyte metabolism can regulate cartilage homeostasis, the specific stress-response condition is therefore a key to the generation of an OA disease model. We aimed to produce a specific stress- and cell-based OA model after evaluating the metabolic responses of chondrocytes in response to a series of static and cyclic compression stressors. A static load exceeding 40 psi initiated extracellular matrix (ECM) degradation through a decrease in the sulphated-glycosaminoglycan (GAG) content, upregulation of catabolic matrix metalloproteinase (MMP)-13 encoding gene expression, and downregulation of the ECM-related aggrecan and type II collagen encoding genes within 24 h...
May 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28489883/bmp-7-induces-apoptosis-in-human-germinal-center-b-cells-and-is-influenced-by-tgf-%C3%AE-receptor-type-i-alk5
#20
Lise K Bollum, Kanutte Huse, Morten P Oksvold, Baoyan Bai, Vera I Hilden, Lise Forfang, Sun Ok Yoon, Sébastien Wälchli, Erlend B Smeland, June H Myklebust
Selection and maturation of B cells into plasma cells producing high-affinity antibodies occur in germinal centers (GC). GCs form transiently in secondary lymphoid organs upon antigen challenge, and the GC reaction is a highly regulated process. TGF-β is a potent negative regulator, but the influence of other family members including bone morphogenetic proteins (BMPs) is less known. Studies of human peripheral blood B lymphocytes showed that BMP-6 suppressed plasmablast differentiation, whereas BMP-7 induced apoptosis...
2017: PloS One
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