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https://www.readbyqxmd.com/read/28527270/-effect-of-antenatal-spiramycin-treatment-on-the-frequency-of-retinochoroiditis-due-to-congenital-toxoplasmosis-in-a-colombian-cohort
#1
Liliana María Zuluaga, John Camilo Hernández, Carlos Felipe Castaño, Jorge Hernando Donado
INTRODUCTION: Gestational toxoplasmosis is frequent and severe. There is still debate about the benefits of treatment against ocular manifestations in the newborn. Spiramycin treatment is used for this purpose, unfortunately prenatal diagnosis is sometimes delayed and pregnant women are not treated. OBJECTIVE: To describe the relationship between treatment with spiramycin during pregnancy in mothers with gestational toxoplasmosis and development of ocular toxoplasmosis in newborns...
April 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28516409/survival-after-severe-rhabdomyolysis-following-monensin-ingestion
#2
Michela Blain, Alexander Garrard, Robert Poppenga, Betty Chen, Matthew Valento, Melissa Halliday Gittinger
INTRODUCTION: Monensin is a veterinary antibiotic with a narrow therapeutic window that has led to lethal intoxication in many animal species. Only two prior cases of human toxicity have been reported, both fatal. We present the first case of survival from severe toxicity following monensin ingestion. CASE: A 58-year-old man presented with 8 days of vomiting and abdominal pain. Due to delusions of central nervous system toxoplasmosis, he ingested 300 mg of monensin...
May 17, 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/28513493/inflammatory-choroidal-neovascularization-in-indian-eyes-etiology-clinical-features-and-outcomes-to-anti-vascular-endothelial-growth-factor
#3
Rupak Roy, Kumar Saurabh, Aditya Bansal, Amitabh Kumar, Anindya Kishore Majumdar, Swakshyar Saumya Paul
BACKGROUND AND OBJECTIVES: The aim was to study the clinical profile of inflammatory choroidal neovascularization (CNV) and its treatment response to intravitreal bevacizumab or ranibizumab on pro re nata (PRN) basis in Indian eyes. MATERIALS AND METHODS: This was a retrospective case series of consecutive patients with inflammatory CNV treated with anti-vascular endothelial growth factor (anti-VEGF) in a tertiary eye care center in Eastern India between 2009 and 2014...
April 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28491442/respiratory-distress-associated-with-lungworm-infection-in-a-kitten
#4
Melissa M Hawley, Lynelle R Johnson, Donato Traversa, Dan Bucy, Karen M Vernau, William Vernau
CASE SUMMARY: A 5-month-old feral kitten developed worsening respiratory signs, including tachypnea, coughing and wheezing after standard anthelmintic treatment with fenbendazole at a local shelter. The kitten was referred to the University of California, Davis, William R Pritchard Veterinary Medicine Teaching Hospital for further evaluation. Thoracic radiographs revealed a severe diffuse bronchointerstitial pattern with bronchial cuffing, ill-defined nodules and lymphadenomegaly. Differentials included infectious etiologies such as toxoplasmosis, feline infectious peritonitis and cryptococcosis...
July 2016: JFMS Open Rep
https://www.readbyqxmd.com/read/28486997/the-antifungal-aureobasidin-a-and-an-analogue-are-active-against-the-protozoan-parasite-toxoplasma-gondii-but-do-not-inhibit-sphingolipid-biosynthesis
#5
A Q I Alqaisi, A J Mbekeani, M Bassas Llorens, A P Elhammer, P W Denny
Toxoplasma gondii is an obligate intracellular protozoan parasite of the phylum Apicomplexa, and toxoplasmosis is an important disease of both humans and economically important animals. With a limited array of drugs available there is a need to identify new therapeutic compounds. Aureobasidin A (AbA) is an antifungal that targets the essential inositol phosphorylceramide (IPC, sphingolipid) synthase in pathogenic fungi. This natural cyclic depsipeptide also inhibits Toxoplasma proliforation, with the protozoan IPC synthase orthologue proposed as the target...
May 10, 2017: Parasitology
https://www.readbyqxmd.com/read/28486633/development-of-a-murine-vertical-transmission-model-for-toxoplasma-gondii-oocyst-infection-and-studies-on-the-efficacy-of-bumped-kinase-inhibitor-bki-1294-and-the-naphthoquinone-buparvaquone-against-congenital-toxoplasmosis
#6
Joachim Müller, Adriana Aguado-Martínez, Luis-Miguel Ortega-Mora, Javier Moreno-Gonzalo, Ignacio Ferre, Matthew A Hulverson, Ryan Choi, Molly C McCloskey, Lynn K Barrett, Dustin J Maly, Kayode K Ojo, Wes Van Voorhis, Andrew Hemphill
Objectives: Establishment of a mouse model for congenital toxoplasmosis based on oral infection with oocysts from Toxoplasma gondii ME49 and its application for investigating chemotherapeutic options against congenital toxoplasmosis. Methods: CD1 mice were mated, orally infected with 5, 25, 100, 500 or 2000 oocysts and monitored for clinical signs and survival of dams and pups until 4 weeks post partum . The parasite burden in infected mice was quantified by real-time PCR in lungs, brains and, in the case of surviving pups, also in eyes...
May 9, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28484433/toxoplasma-gondii-infection-induces-high-mobility-group-box-1-released-from-mouse-macrophages
#7
Hui Wang, Muzi Li, Jing Liu, Jianhai Xu, Qian Han, Qun Liu
High mobility group box 1 (HMGB1) is abundantly expressed in intracellular engaged DNA binding ability. However, more importantly, it is a weapon against infection through proinflammatory response and immune regulation while released to extracellular. Toxoplasma gondii causes inflammatory pathological changes including ileitis and encephalitis in chronic infection. To investigate whether HMGB1 contributes to the toxoplasmosis lesions, we examined HMGB1 changes during T. gondii infection. The results showed that HMGB1 transcription was down-regulated in the murine macrophage ANA1 cell line and mouse peritoneal macrophages (PMΦs) after T...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28477099/nanomedicine-advances-in-toxoplasmosis-diagnostic-treatment-and-vaccine-applications
#8
REVIEW
João Paulo Assolini, Virginia Márcia Concato, Manoela Daiele Gonçalves, Amanda Cristina Machado Carloto, Ivete Conchon-Costa, Wander Rogério Pavanelli, Francine Nesello Melanda, Idessania Nazareth Costa
Toxoplasmosis is an infectious disease caused by the intracellular parasite Toxoplasma gondii that affects about one third of the world's population. The diagnosis of this disease is carried out by parasite isolation and host antibodies detection. However, the diagnosis presents problems in regard to test sensitivity and specificity. Currently, the most effective T. gondii treatment is a combination of pyrimethamine and sulfadiazine, although both drugs are toxic to the host. In addition to the problems that compromise the effective diagnosis and treatment of toxoplasmosis, there are no reports or indications of any vaccine capable of fully protecting against this infection...
May 5, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28462207/toxoplasma-gondii-and-pre-treatment-protocols-for-polymerase-chain-reaction-analysis-of-milk-samples-a-field-trial-in-sheep-from-southern-italy
#9
Alice Vismarra, Elena Barilli, Maura Miceli, Carlo Mangia, Cristina Bacci, Franco Brindani, Laura Kramer
Toxoplasmosis is a zoonotic disease caused by the protozoan Toxoplasma gondii. Ingestion of raw milk has been suggested as a risk for transmission to humans. Here the authors evaluated pre-treatment protocols for DNA extraction on T. gondii tachyzoite-spiked sheep milk with the aim of identifying the method that resulted in the most rapid and reliable polymerase chain reaction (PCR) positivity. This protocol was then used to analyse milk samples from sheep of three different farms in Southern Italy, including real time PCR for DNA quantification and PCR-restriction fragment length polymorphism for genotyping...
January 24, 2017: Italian Journal of Food Safety
https://www.readbyqxmd.com/read/28448726/intravitreal-injection-of-sulfamethoxazole-and-trimethoprim-associated-with-dexamethasone-as-an-alternative-therapy-for-ocular-toxoplasmosis
#10
Carlos E Souza, Heloisa Nascimento, Acácio Lima, Cristina Muccioli, Rubens Belfort
PURPOSE: To evaluate intravitreal injections of sulfamethoxazole/trimethoprim in association with dexamethasone for treating toxoplasmic retinochoroiditis. METHODS: Thirteen patients with active, recurrent ocular focal toxoplasmic retinochoroiditis and visual acuity worse than 20/63 in the affected eye were included. Ocular toxoplasmosis was diagnosed according to the classic clinical findings. The primary end point was the change in the final best-corrected visual acuity (BCVA)...
April 27, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28448521/immunization-with-toxoplasma-gondii-peroxiredoxin-1-induces-protective-immunity-against-toxoplasmosis-in-mice
#11
Ragab M Fereig, Yasuhiro Kuroda, Mohamad Alaa Terkawi, Motamed Elsayed Mahmoud, Yoshifumi Nishikawa
To develop a vaccine against Toxoplasma gondii, a vaccine antigen with immune-stimulating activity is required. In the present study, we investigated the immunogenicity and prophylactic potential of T. gondii peroxiredoxin 1 (TgPrx1). The TgPrx1 was detected in the ascitic fluid of mice 6 days postinfection, while specific antibody levels were low in the sera of chronically infected mice. Treatment of murine peritoneal macrophages with recombinant TgPrx1 triggered IL-12p40 and IL-6 production, but not IL-10 production...
2017: PloS One
https://www.readbyqxmd.com/read/28433574/serodiagnosis-of-toxoplasmosis-the-effect-of-measurement-of-igg-avidity-in-pregnant-women-in-rabat-in-morocco
#12
Majda Laboudi, Abderrahim Sadak
BACKGROUND: The diagnosis of Toxoplasmosis in pregnant women during the early first trimester of pregnancy is very important for preventing congenital infection of the fetus; it will not only prevent the risk of transmitting the infection to the fetus but it will also enable to give these women a preventive treatment. In this study, the avidity test was performed on pregnant women during their first prenatal visit at the National Institute of Hygiene in Rabat, Morocco. FINDINGS: One hundred and twenty-eight sera samples were collected from 128 pregnant women between August 2015 and June 2016; these women were chosen retrospectively and were in their first four months of pregnancy...
April 20, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28414523/presence-of-toxoplasma-gondii-in-drinking-water-from-an-endemic-region-in-southern-mexico
#13
Ivonne B Hernandez-Cortazar, Karla Y Acosta-Viana, Eugenia Guzman-Marin, Antonio Ortega-Pacheco, Jose C Segura-Correa, Matilde Jimenez-Coello
Toxoplasmosis can be acquired through the ingestion of contaminated drinking water with oocysts of Toxoplasma gondii, highly resistant to the routinely disinfection processes; based on chlorination commonly used in the water supply industry. The aim of this study was to determine the presence of T. gondii DNA in samples of public drinking water from an endemic region of southern Mexico. In total 74 samples of water (5 L each) were collected from the three well fields (I, II, and III) and 71 independent wells, distributing public drinking water to the city of Merida Yucatan, after passing through the chlorination process...
May 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28397514/fatal-disseminated-toxoplasmosis-in-a-zoological-collection-of-meerkats-i-suricata-suricatta-i
#14
Monica Burger, Elizabeth C Du Plessis, Essa Suleman, Brett R Gardner
Two confirmed cases of fatal disseminated toxoplasmosis occurred in an urban zoological collection of meerkats (Suricata suricatta). Both cases are suspected to be the result of feral cats gaining access to the enclosure. Toxoplasmosis has rarely been documented in meerkats. Subsequent to prophylactic treatment of all the animals and structural changes being implemented within the enclosure, no new cases have been recorded to date. Very little information is available on the disease in viverrids.
March 31, 2017: Journal of the South African Veterinary Association
https://www.readbyqxmd.com/read/28394985/-chagas-disease-affecting-the-central-nervous-system-in-a-patient-with-aids-demonstrated-by-quantitative-molecular-methods
#15
Alberto Fica, Marcia Salinas, María Isabel Jercic, Jeannette Dabanch, Andrés Soto, Sergio Quintanilla, Carlos Flores
Although infrequent, Trypanosoma cruzi reactivation is possible among patients with HIV/AIDS infection that develop a tumor-like or granulomatous lesion in the CNS. We report the case of a 60 years old male patient with HIV/AIDS and low CD4 lymphocytes count with cerebellar symptoms and mild paresis, associated to supra and infratentorial hypodense lesions and positive serology tests both to T. gondii and Trypanosoma cruzi. Empirical therapy against toxoplasmosis was prescribed together with antiretroviral therapy but without a favorable response...
February 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28329892/ocular-toxoplasmosis-therapy-related-adverse-drug-reactions-and-their-management
#16
M Helfenstein, S Zweifel, D Barthelmes, F Meier, J Fehr, C Böni
Background There are different treatment options for ocular toxoplasmosis (OT). "Classic" therapy consists of pyrimethamine, sulfadiazine and folinic acid combined with systemic steroids and is still widely used. However, potentially severe side effects of this therapy have been reported. The aim of this retrospective study was to evaluate the incidence and types of adverse drug reactions in patients treated for OT. Clinical management of each adverse drug reaction was assessed. Patients and Methods In this retrospective analysis, we reviewed data of patients with OT, who were consecutively examined between December 2011 and December 2015 at the Department of Ophthalmology, University Hospital Zurich...
April 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28326747/laboratory-methods-for-diagnostics-of-hiv-infection-and-hiv-associated-neuroinfections
#17
Pavol Beno, Alzbeta Kaiglova, Martin Samohyl
HIV Infection resulting in AIDS remains serious global public health problem. In the fight with the global health problem plays a key role a simple, reliable and fast diagnostics. An important method in diagnostics is the identification and detection of viral capside p24 antigen levels. Fourth generation tests for the diagnostics of HIV infection simultaneously detect the presence of HIV antibodies and p24 antigen. Based on the monitoring of CD4 count, we can estimate the stage in which the infection is, and we can also suggest a therapeutic approach...
January 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28283010/-effects-of-azithromycin-and-chlorella-vulgaris-treatment-on-certain-cytokine-values-and-nk-cell-activity-in-an-acute-murine-toxoplasmosis-model
#18
Deniz Gözde Çelik Payçu, Özden Büyükbaba Boral
Toxoplasmosis is a common infection with a complicated treatment process. Azithromycin (AZT) is a macrolide antibiotic that can be effectively used in patients with cerebral and ocular toxoplasmosis and has fewer side effects. Chlorella vulgaris (CV), a single-cell green algae that contains nutrients and has various biological effects. CV extract (CVE) has been shown to have protective effects against infections via immune enhancement by increasing the cytotoxicity of NK cells, IL-12 and IFN-γ levels. The aim of this study was to investigate the protective effects of AZT and CV, individually and in combination, against acute toxoplasmosis in mice, and their effects on NK cell cytotoxixity, IL-12, IFN-γ, and IL-2 levels...
January 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28280256/late-onset-cerebral-toxoplasmosis-after-allogeneic-hematopoietic-stem-cell-transplantation
#19
Ahmed M Khalaf, Mahmoud A Hashim, Mohammed Alsharabati, Kenneth Fallon, Joel K Cure, Peter Pappas, Shin Mineishi, Ayman Saad
BACKGROUND Toxoplasmosis is an uncommon but potentially fatal complication following allogeneic hematopoietic stem cell transplantation (HCT). Post-transplant toxoplasmosis is often a reactivation of prior infection and typically occurs within the first 6 months of transplant. Herein, we report that cerebral toxoplasmosis may occur 22 months after allogeneic hematopoietic stem cell transplantation. CASE REPORT We describe a case of cerebral toxoplasmosis that occurred 22 months after an allogeneic HCT while the patient was on aerosolized pentamidine for Pneumocystis jiroveci pneumonia (PCP) prophylaxis...
March 10, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28276701/genomics-of-apicomplexan-parasites
#20
Lakshmipuram Seshadri Swapna, John Parkinson
The increasing prevalence of infections involving intracellular apicomplexan parasites such as Plasmodium, Toxoplasma, and Cryptosporidium (the causative agents of malaria, toxoplasmosis, and cryptosporidiosis, respectively) represent a significant global healthcare burden. Despite their significance, few treatments are available; a situation that is likely to deteriorate with the emergence of new resistant strains of parasites. To lay the foundation for programs of drug discovery and vaccine development, genome sequences for many of these organisms have been generated, together with large-scale expression and proteomic datasets...
February 22, 2017: Critical Reviews in Biochemistry and Molecular Biology
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