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https://www.readbyqxmd.com/read/29153269/vitamin-d-pathway-gene-polymorphisms-influenced-vitamin-d-level-among-pregnant-women
#1
Bule Shao, Shuying Jiang, Xiamusiye Muyiduli, Shuojia Wang, Minjia Mo, Minchao Li, Zhaopin Wang, Yunxian Yu
AIMS: To explore the relationship between vitamin D pathway genes, gene-environment interactions and vitamin D level among southeast Chinese pregnant women. METHODS: 759 participants from Zhoushan Pregnant Women Cohort (ZPWC) study, were enrolled from August 2011 to April 2014 in China. Plasma 25(OH)D levels and genetic variants in vitamin D pathway (NADSYN1/DHCR7, GC, CYP3A4, CYP2R1, CYP27A1, CYP27B1, VDR, CYP24A1, and LRP2) were measured using the blood sample collected at the first trimester...
November 7, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29116467/vitamin-d-supplementation-decreases-serum-27-hydroxycholesterol-in-a-pilot-breast-cancer-trial
#2
Catherine C Going, Ludmila Alexandrova, Kenneth Lau, Christine Y Yeh, David Feldman, Sharon J Pitteri
PURPOSE: 27-hydroxycholesterol (27HC), an endogenous selective estrogen receptor modulator (SERM), drives the growth of estrogen receptor-positive (ER+) breast cancer. 1,25-dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D, is known to inhibit expression of CYP27B1, which is very similar in structure and function to CYP27A1, the synthesizing enzyme of 27HC. Therefore, we hypothesized that 1,25(OH)2D may also inhibit expression of CYP27A1, thereby reducing 27HC concentrations in the blood and tissues that express CYP27A1, including breast cancer tissue...
November 7, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29115640/off%C3%A2-target-effect-of-imatinib-and-nilotinib-on-human-vitamin-d3-metabolism
#3
Lysann Kroschwald, Meinolf Suttorp, Josephine Tabea Tauer, Nick Zimmermann, Claudia Günther, Andrea Bauer
Prolonged treatment with tyrosine kinase inhibitors (TKI) including imatinib (IMA) or nilotinib (NIL), induces severe disturbances of bone metabolism in patients with chronic myeloid leukaemia. As vitamin D3 (VD3) is involved in the complex cycle of bone remodelling, the present study investigated in vitro, the influence of IMA and NIL on VD3 metabolism i) in HaCaT cells and ii) in cultured outer root sheath keratinocytes (ORS‑KC) from hair follicles of IMA treated children. Cells were incubated in the presence of IMA or NIL...
November 3, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29110708/co-expression-of-1%C3%AE-hydroxylase-and-vitamin-d-receptor-in-human-articular-chondrocytes
#4
Ann Kristin Hansen, Yngve Figenschau, Inigo Zubiaurre-Martinez
BACKGROUND: The aim was to investigate whether resident chondrocytes in human articular cartilage and in subculture express vitamin D receptor (VDR) and the enzyme that hydroxylates the prohormone 25(OH)D3 to the active hormone 1α,25(OH)2D3, namely 1α-hydroxylase (CYP27B1). Any putative effects of vitamin D on chondrocytes were also explored. METHODS: Cartilage from human osteoarthritic knee joints, cultured chondrocytes and cells grown in 3D spheroids were examined for the expression of VDR and 1α-hydroxylase by PCR, Western blots and immunolabelling...
November 6, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29109124/endogenous-calcitriol-synthesis-controls-the-humoral-ige-response-in-mice
#5
Juliane Lindner, Sebastian Rausch, Sandra Treptow, Kerstin Geldmeyer-Hilt, Tina Krause, René St-Arnaud, Alice Arabian, Andreas Radbruch, Susanne Hartmann, Margitta Worm, Guido Heine
The vitamin D receptor participates in the control of IgE class-switch recombination in B cells. The physiologic vitamin D receptor agonist, 1,25(OH)2D3 (calcitriol), is synthesized by the essential enzyme 25-hydroxyvitamin D3-1α-hydroxylase (CYP27B1), which can be expressed by activated immune cells. The role of endogenous calcitriol synthesis for the regulation of IgE has not been proven. In this study, we investigated IgE-responses in Cyp27b1-knockout (KO) mice following sensitization to OVA or intestinal infection with Heligmosomoides polygyrus Specific Igs and plasmablasts were determined by ELISA and ELISpot, Cyp27b1 expression was measured by quantitative PCR...
November 6, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29109081/vitamin-d-the-placenta-and-early-pregnancy-effects-on-trophoblast-function
#6
Ankana Ganguly, Jennifer Ann Tamblyn, Sarah Finn-Sell, Shiao-Yng Chan, Melissa Westwood, Janesh Gupta, Mark Kilby, Stephane R Gross, Martin Hewison
Pregnancy is associated with significant changes in vitamin D metabolism, notably increased maternal serum levels of active vitamin D, 1,25-dihydroxyvitamin (1,25(OH)2D). This appears to be due primarily to increased renal activity of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) that catalyzes synthesis of 1,25(OH)2D, but CYP27B1 expression is also prominent in both the maternal decidua and fetal trophoblast components of the placenta. The precise function of placental synthesis of 1,25(OH)2D remains unclear, but is likely to involve localised tissue-specific responses with both decidua and trophoblast also expressing the vitamin D receptor (VDR) for 1,25(OH)2D...
November 6, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/29107736/absence-of-vitamin-d-receptor-in-mature-osteoclasts-results-in-altered-osteoclastic-activity-and-bone-loss
#7
Yolandi Starczak, Daniel C Reinke, Kate R Barratt, Jackson W Ryan, René St-Arnaud, Howard A Morris, Rachel A Davey, Gerald J Atkins, Paul H Anderson
Mature osteoclasts express the vitamin D receptor (VDR) and are able to synthesise and respond to 1,25(OH)2D3 via CYP27B1 enzyme activity. Whether vitamin D signalling within osteoclasts is necessary for the regulation of osteoclastic bone resorption in an in vivo setting is unclear. To determine the requirement for the VDR- and CYP27B1-mediated activity in mature osteoclasts, conditional deletion mouse models were created whereby either Vdr or Cyp27b1 gene was inactivated by breeding either Vdr(fl/fl) or Cyp27b1(fl/fl) mice with Cathepsin K-Cre transgenic mice (Cstk(Cre)) to generate Ctsk(Cre)/Vdr(-/-) and Ctsk(Cre)/Cyp27b1(-/-) mice respectively...
October 28, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29099735/effect-of-pharmacogenetic-markers-of-vitamin-d-pathway-on-deferasirox-pharmacokinetics-in-children
#8
Sarah Allegra, Jessica Cusato, Silvia De Francia, Filomena Longo, Elisa Pirro, Davide Massano, Antonio Piga, Antonio D'Avolio
OBJECTIVES: Patients with β-thalassemia major have extremely low vitamin D levels, owing to reduced intestinal absorption, subicteric tint, and/or iron-induced higher pigmentation. We investigated whether some polymorphisms within the VDR, CYP24A1, CYP27B1, and GC genes could play a role in deferasirox pharmacokinetics in a cohort of pediatric patients. PATIENTS AND METHODS: Eighteen children with β-thalassemia were enrolled. Drug plasma concentrations at the end of dosing interval (Ctrough) and after 0, 2, 4, 6, and 24 h of drug administration were measured by a HPLC-UV method...
November 2, 2017: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29093562/glucocorticoid-exposure-induces-preeclampsia-via-dampening-1-25-dihydroxyvitamin-d3
#9
Dongxin Zhang, Ji Zeng, Xili Miao, Haojing Liu, Liangfang Ge, Wei Huang, Jinyu Jiao, Duyun Ye
The pathogenesis of preeclampsia (PE) involves a number of biological processes that may be directly or indirectly affected by glucocorticoid (GC) and vitamin D. GC exposure increases the risk of PE, and 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) deficiency may result in PE. The purpose of the present study was to confirm the involvement of GC/1,25-(OH)2D3 axis in the pathogenesis of PE. In the study, cortisol levels of PE patients were found to be higher than that of non-complicated pregnancies, while 1,25-(OH)2D3 were decreased in both PE women and GC-induced PE rats...
November 2, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29089453/calcitriol-regulates-immune-genes-cd14-and-cd180-to-modulate-lps-responses-in-human-trophoblasts
#10
Mark S Longtine, Silvija Cvitic, Bryanne N Colvin, Baosheng Chen, Gernot Desoye, D Michael Nelson
We assessed the response of primary cultures of placental villous mononucleated trophoblasts and multinucleated syncytiotrophoblast to calcitriol, the most biologically active form of vitamin D. Whole-genome microarray data showed that calcitriol modulates the expression of many genes in trophoblasts within 6 hours of exposure and RT-qPCR revealed similar responses in cytotrophoblasts, syncytiotrophoblasts and villous explants. Both cytotrophoblasts and syncytiotrophoblasts expressed genes for the vitamin D receptor, for LRP2 and CUBN that mediate internalization of calcidiol, for CYP27B1 that encodes the enzyme that converts calcidiol into active calcitriol, and for CYP24A1 that encodes the enzyme that modifies calcitriol and calcidiol to inactive calcitetrol...
December 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29080636/genetic-diseases-of-vitamin-d-metabolizing-enzymes
#11
REVIEW
Glenville Jones, Marie Laure Kottler, Karl Peter Schlingmann
Vitamin D metabolism involves 3 highly specific cytochrome P450 (CYP) enzymes (25-hydroxylase, 1α-hydroxylase, and 24-hydroxylase) involved in the activation of vitamin D3 to the hormonal form, 1,25-(OH)2D3, and the inactivation of 1,25-(OH)2D3 to biliary excretory products. Mutations of the activating enzymes CYP2R1 and CYP27B1 cause lack of normal 1,25-(OH)2D3 synthesis and result in rickets whereas mutations of the inactivating enzyme CYP24A1 cause build-up of excess 1,25-(OH)2D3 and result in hypercalcemia, nephrolithiasis, and nephrocalcinosis...
December 2017: Endocrinology and Metabolism Clinics of North America
https://www.readbyqxmd.com/read/29074827/-update-on-recent-progress-in-vitamin-d-research-the-effects-of-vitamin-d-in-autoinflammatory-diseases
#12
Tomoka Ao, Junichi Kikuta, Masaru Ishii
Various kinds of immune cells -including dendritic cells, macrophages, T cells and B cells- express the vitamin D receptor and 1α-hydroxylase(CYP27B1). In vitro studies have shown the anti-inflammatory effect of 1,25-dihydroxyvitamin D:the active form of vitamin D. As vitamin D deficiency spread in our society, epidemiological studies have established the association between vitamin D deficiency and incidence or progression of several inflammatory diseases, including rheumatoid arthritis(RA), systemic lupus erythematosus(SLE), and multiple sclerosis(MS)...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/29074823/-update-on-recent-progress-in-vitamin-d-research-vitamin-d-metabolism-and-its-regulation
#13
Toshimi Michigami
Vitamin D is taken up from food as D2 and D3. Vitamin D3 is also synthesized from 7-dehydrocholesterol in the skin by the exposure of ultraviolet B. The D2 and D3, which are called native vitamin D, are hydroxylated at C25 in the liver by CYP2R1 and then at C1 in the kidney by CYP27B1, to be converted to an active vitamin D metabolite, 1,25-dihydroxyvitamin D[1,25(OH)2D]. CYP24A1 converts 25-hydroxyvitamin D(25OHD)and 1,25(OH)2D to 24,25-dihydroxyvitamin D[24,25(OH)2D]and 1,24,25-trihydroxyvitamin D[1,24,25(OH)3D], respectively, to decrease the level of 1,25(OH)2D...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/29061729/plasma-25-hydroxyvitamin-d-concentration-and-risk-of-islet-autoimmunity
#14
Jill M Norris, Hye-Seung Lee, Brittni Frederiksen, Iris Erlund, Ulla Uusitalo, Jimin Yang, Åke Lernmark, Olli Simell, Jorma Toppari, Marian Rewers, Anette-G Ziegler, Jin-Xiong She, Suna Onengut-Gumuscu, Wei-Min Chen, Stephen S Rich, Jouko Sundvall, Beena Akolkar, Jeffrey Krischer, Suvi M Virtanen, William Hagopian
We examined the association between plasma 25-hydroxyvitamin D (25[OH]D) concentration and islet autoimmunity(IA); and whether vitamin D gene polymorphisms modify the effect of 25(OH)D on IA risk. We followed 8676 children at increased genetic risk of type 1 diabetes(T1D) at 6 sites in the US and Europe. We defined IA as positivity for at least one autoantibody (GADA, IAA or IA-2A) on 2 or more visits. We conducted a risk-set sampled nested case-control study of 376 IA cases and up to 3 controls per case. 25(OH)D concentration was measured on all samples prior to, and including the first IA positive visit...
October 23, 2017: Diabetes
https://www.readbyqxmd.com/read/29055009/in-search-of-regulatory-circuits-that-control-the-biological-activity-of-vitamin-d
#15
REVIEW
Sylvia Christakos
Although the cytochrome P450 CYP27B1 plays a critical role in vitamin D biology, the molecular mechanisms involved in regulation of CYP27B1 have remained undefined. A new study has identified a kidney-specific control module distal to the Cyp27b1 gene that mediates the basal activity and hormonal regulation of Cyp27b1 This work provides a novel mechanism indicating differential regulation of Cyp27b1 in renal and non-renal cells and has implications for vitamin D biology in multiple sclerosis and perhaps other autoimmune diseases as well...
October 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29021285/placental-vitamin-d-metabolism-and-its-associations-with-circulating-vitamin-d-metabolites-in-pregnant-women
#16
Heyjun Park, Madeleine R Wood, Olga V Malysheva, Sara Jones, Saurabh Mehta, Patsy M Brannon, Marie A Caudill
Background: Little is known about placental vitamin D metabolism and its impact on maternal circulating vitamin D concentrations in humans.Objective: This study sought to advance the current understanding of placental vitamin D metabolism and its role in modulating maternal circulating vitamin D metabolites during pregnancy.Design: Nested within a feeding study, 24 healthy pregnant women (26-29 wk of gestation) consumed a single amount of vitamin D (511 IU/d from diet and a cholecalciferol supplement) for 10 wk...
October 11, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28986304/molecular-profiles-of-oxyphilic-and-chief-cell-parathyroid-adenoma
#17
Ming Lu, Hanna Kjellin, Omid Fotouhi, Linkiat Lee, Inga-Lena Nilsson, Felix Haglund, Anders Höög, Janne Lehtiö, Catharina Larsson
CONTEXT: Parathyroid adenomas may be composed of chief cells (conventional or water-clear), oxyphilic cells or a mixture of both cells. The molecular background is rarely studied. OBJECTIVE: To molecularly characterize parathyroid adenomas of different cell type composition. DESIGN: Chief and oxyphilic cell adenomas were compared in a cohort of 664 sporadic cases. Extensive analyses of parathyroid tissues were performed in subgroup. Gene expressions of known parathyroid-related genes were quantified by qRT-PCR...
October 3, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28978148/allergen-specific-immunotherapy-enhanced-defense-against-bacteria-via-tgf-%C3%AE-1-induced-cyp27b1-in-asthma
#18
Junyi Wang, Xiaoyu Liu, Hui Wang, Yin Li, Nan Lan, Xiefang Yuan, Min Wu, Zhigang Liu, Guoping Li
Allergen specific immunotherapy (SIT) is the only specific treatment of allergic diseases at present. How SIT impacts pulmonary innate immunity against bacteria currently remains unclear. In this study, dust mite extracts (HDM)-sensitized mice were immunized with a subcutaneous injection of HDM. These mice were then challenged with an intranasal administration of HDM. After the last challenge, mice were infected with an intranasal instillation with P. aeruginosa (P.a). We measured the score of tissue inflammation, the expression of cathelicidin-related antimicrobial peptide (CRAMP) and 25-Hydroxyvitamin D-1Alpha-hydroxylase (CYP27B1) in lung...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938443/microbiota-dependent-induction-of-colonic-cyp27b1-is-associated-with-colonic-inflammation-implications-of-locally-produced-1-25-dihydroxyvitamin-d3-in-inflammatory-regulation-in-the-colon
#19
Jie Du, Xinzhi Wei, Xin Ge, Yinyin Chen, Yan Chun Li
Our recent studies demonstrated that intestinal epithelial vitamin D receptor (VDR) signaling plays a critical role in regulating colonic inflammation by protecting epithelial barrier integrity. Epithelial VDR is downregulated in colitis, but how mucosal inflammation affects local 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] production is unknown. Here we showed that cytochrome P450 27b1 (Cyp27b1), a cytochrome P450 enzyme necessary for 1,25(OH)2D3 biosynthesis, is highly induced in colonic mucosa in inflammatory response...
November 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28902929/women-with-recurrent-spontaneous-abortion-have-decreased-25-oh-vitamin-d-and-vdr-at-the-fetal-maternal-interface
#20
COMPARATIVE STUDY
N Li, H M Wu, F Hang, Y S Zhang, M J Li
Immunological mechanisms have been proposed to underlie the pathogenesis of recurrent spontaneous abortion (RSA). Vitamin D has a potent immunomodulatory effect, which may affect pregnancy outcome. The objective of this study was to investigate 25-hydroxyvitamin D [25(OH) D] concentration and vitamin D receptor (VDR) expression in the decidual tissues of RSA patients. Thirty women with RSA (RSA group) and thirty women undergoing elective abortion (control group) were recruited during 2016 from gynecology outpatient clinics...
September 12, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
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