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hydroxy fatty acid

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https://www.readbyqxmd.com/read/27905210/erythrocyte-fatty-acid-composition-does-not-influence-levels-of-free-bioavailable-and-total-25-hydroxy-vitamin-d
#1
Martin Carlsson, Ingela Nilsson, Lars Brudin, Siv-Ping Von, Pär Wanby
In vitro, mono- and polyunsaturated fatty acids (FAs) may decrease the binding affinity of vitamin D metabolites for vitamin D-binding protein, which in turn may influence their bioavailability. FAs incorporated as phospholipids in erythrocyte (ery-) cell membranes reflect dietary intake. The purpose of this study was to investigate ery-FA composition in relation to markers for vitamin D. In healthy females (age 22.6 ± 2.0 years) total 25(OH)D was measured by LC-MS/MS (n = 78), free 25(OH)D with ELISA (n = 64 of 78), and bioavailable 25(OH)D was calculated...
December 1, 2016: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/27904937/separation-of-cyclic-lipopeptide-puwainaphycins-from-cyanobacteria-by-countercurrent-chromatography-combined-with-polymeric-resins-and-hplc
#2
José Cheel, Petra Urajová, Jan Hájek, Pavel Hrouzek, Marek Kuzma, Elodie Bouju, Karine Faure, Jiří Kopecký
Puwainaphycins are a recently described group of β-amino fatty acid cyclic lipopeptides of cyanobacterial origin that possess interesting biological activities. Therefore, the development of an efficient method for their isolation from natural sources is necessary. Following the consecutive adsorption of the crude extract on Amberlite XAD-16 and XAD-7 resins, countercurrent chromatography (CCC) was applied to separate seven puwainaphycin variants from a soil cyanobacterium (Cylindrospermum alatosporum CCALA 988)...
November 30, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27902269/description-of-candidatus-marispirochaeta-associata-and-reclassification-of-spirochaeta-bajacaliforniensis-spirochaeta-smaragdinae-and-spirochaeta-sinaica-to-a-new-genus-sediminispirochaeta-gen-nov-as-sediminispirochaeta-bajacaliforniensis-comb-nov-sediminispirochaeta
#3
Shivani Y, Subhash Y, Sasikala Ch, Ramana Ch V
Strain JC231 was isolated from a coastal saline habitat of Gujarat and was identified based on 16S rRNA gene sequence analysis as a member belonging to the genus Spirochaeta and showed highest sequence similarity (<91%) with Spirochaeta bajacaliforniensis DSM 16054T and other members of the family Spirochaetaceae. Intensive attempts to culture strain JC231 in pure culture has failed and was associated with only one species of a Desulfovibrio. However, presence of fosmidomycin inhibited the growth of Desulfovibrio sp...
October 5, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27899336/complete-genome-sequence-of-stenotrophomonas-sp-kacc-91585-an-efficient-bacterium-for-unsaturated-fatty-acid-hydration
#4
Kyoung-Rok Kim, Woo-Ri Kang, Deok-Kun Oh
Hydroxy fatty acids (HFAs) such as 10-hydroxystearic acid (10-HSA) and 10-hydroxy-12(Z)-octadecenoic acid (10-HOD), which are similar to ricinoleic acid, are important starting materials and intermediates for the industrial manufacture of many commodities. Stenotrophomonas sp. KACC 91585, which was isolated from lake sediment, is an efficient bacterium for unsaturated fatty acid hydration that produces 10-HSA and 10-HOD from oleic acid and linoleic acid, respectively, with high conversion rates. The complete genome of this strain is 4,541,729bp with 63...
November 26, 2016: Journal of Biotechnology
https://www.readbyqxmd.com/read/27897391/a-systematic-review-on-the-role-of-vitamins-minerals-proteins-and-other-supplements-for-the-treatment-of-cachexia-in-cancer-a-european-palliative-care-research-centre-cachexia-project
#5
REVIEW
Mochamat, Henning Cuhls, Milka Marinova, Stein Kaasa, Christiane Stieber, Rupert Conrad, Lukas Radbruch, Martin Mücke
We provide a systematic review to support the European Palliative Care Research Collaboration development of clinical guidelines for cancer patients suffering from cachexia. CENTRAL, MEDLINE, PsycINFO, ClinicalTrials.gov, and a selection of cancer journals have been searched up until 15 April 2016. The systematic literature research yielded 4214 publications with 21 of these included in the final evaluation. Regarding minerals, our search identified only one study examining the use of magnesium with no effect on weight loss...
July 20, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27896686/blastococcus-colisei-sp-nov-isolated-from-an-archaeological-amphitheatre
#6
Karima Hezbri, Imen Nouioui, Manfred Rohde, Peter Schumann, Maher Gtari, Hans-Peter Klenk, Maria Del Carmen Montero-Calasanz, Faten Ghodhbane-Gtari
The taxonomic position of an actinobacterial isolate, designated strain BMG 822(T), isolated from limestone from the Amphitheater of El Jem (Coliseum Thysdrus), Tunisia, was established using a polyphasic approach. Strain BMG 822(T) was found to grow well at 30 °C and pH 6.5-8.0, and to be coral-coloured, Gram-positive, catalase and oxidase negative. Whole cell hydrolysates contained meso-diaminopimelic acid as the diagnostic diamino acid, glucose, galactose and ribose. The phospholipids detected were diphosphatidylglycerol, phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine, hydroxy-phosphatidylethanolamine, an unidentified glycophospholipid and six unidentified phospholipids...
November 28, 2016: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/27870954/synthesis-and-characterization-of-o-acylated-%C3%AF-hydroxy-fatty-acids-as-skin-protecting-barrier-lipids
#7
B Pérez, S E Dahlgaard, P Bulsara, A V Rawlings, M M Jensen, M Dong, M Glasius, M J Clarke, Z Guo
A series of O-acylated-ω-hydroxy fatty acids (Acyl acids) of up to 34 carbons were synthesized and characterized through DSC, FTIR and Langmuir isotherm measurements to identify potential replacements to petrolatum, a highly used occlusive technology that if unrefined, it can potentially be classified as carcinogenic. Fourier transform infrared spectroscopy studies demonstrated that long acyl acids engender orthorhombic packing; packing behavior that is predominant in the lipid matrix of healthy stratum corneum, the outmost layer of the skin...
November 10, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27863255/epoxyalcohol-synthase-of-ectocarpus-siliculosus-first-cyp74-related-enzyme-of-oxylipin-biosynthesis-in-brown-algae
#8
Yana Y Toporkova, Valeria S Fatykhova, Yuri V Gogolev, Bulat I Khairutdinov, Lucia S Mukhtarova, Alexander N Grechkin
Enzymes of CYP74 family play the central role in the biosynthesis of physiologically important oxylipins in land plants. Although a broad diversity of oxylipins is known in the algae, no CYP74s or related enzymes have been detected in brown algae yet. Cloning of the first CYP74-related gene CYP5164B1 of brown alga Ectocarpus siliculosus is reported in present work. The recombinant protein was incubated with several fatty acid hydroperoxides. Linoleic acid 9-hydroperoxide (9-HPOD) was the preferred substrate, while linoleate 13-hydroperoxide (13-HPOD) was less efficient...
November 15, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27852305/schisandra-polysaccharide-inhibits-hepatic-lipid-accumulation-by-downregulating-expression-of-srebps-in-nafld-mice
#9
Chun-Mei Wang, Rong-Shuang Yuan, Wen-Yue Zhuang, Jing-Hui Sun, Jin-Ying Wu, He Li, Jian-Guang Chen
BACKGROUND: Hepatoprotective effects of Chinese herbal medicine Schisandra Chinensis (Schisandra) have been widely investigated. However, most studies were focused on its lignan extracts. We investigated the effects of Schisandra polysaccharide (SCP) in a mouse model of non-alcoholic fatty liver disease (NAFLD), and studied its effect on sterol regulatory element binding proteins (SREBPs) and the related genes. METHODS: The mouse model of NAFLD was established by feeding mice with a high-fat diet for 16 weeks...
November 16, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27847405/in-vitro-anti-inflammatory-effects-of-three-fatty-acids-from-royal-jelly
#10
Yi-Fan Chen, Kai Wang, Yan-Zheng Zhang, Yu-Fei Zheng, Fu-Liang Hu
Trans-10-hydroxy-2-decenoic acid (10-H2DA), 10-hydroxydecanoic acid (10-HDAA), and sebacic acid (SEA) are the three major fatty acids in royal jelly (RJ). Previous studies have revealed several pharmacological activities of 10-H2DA and 10-HDAA, although the anti-inflammatory effects and underlying mechanisms by which SEA acts are poorly understood. In the present study, we evaluated and compared the in vitro anti-inflammatory effects of these RJ fatty acids in lipopolysaccharide-stimulated RAW 264.7 macrophages...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27845231/streptozotocin-diabetes-increases-mrna-expression-of-ketogenic-enzymes-in-the-rat-heart
#11
George A Cook, Eduard N Lavrentyev, Kevin Pham, Edwards A Park
BACKGROUND: Diabetic cardiomyopathy develops in insulin-dependent diabetic patients who have no hypertension, cardiac hypertrophy or vascular disease. Diabetes increases cardiac fatty acid oxidation, but cardiac hypertrophy limits fatty acid oxidation. Here we examined effects of diabetes on gene expression in rat hearts. METHODS: We used oligonucleotide microarrays to examine effects of insulindependent diabetes in the rat heart. RTQ PCR confirmed results of microarrays...
November 11, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27830762/production-of-ricinoleic-acid-containing-monoestolide-triacylglycerides-in-an-oleaginous-diatom-chaetoceros-gracilis
#12
Masataka Kajikawa, Tatsuki Abe, Kentaro Ifuku, Ken-Ichi Furutani, Dongyi Yan, Tomoyo Okuda, Akinori Ando, Shigenobu Kishino, Jun Ogawa, Hideya Fukuzawa
Ricinoleic acid (RA), a hydroxyl fatty acid, is suitable for medical and industrial uses and is produced in high-oil-accumulating organisms such as castor bean and the ergot fungus Claviceps. We report here the efficient production of RA in a transgenic diatom Chaetoceros gracilis expressing the fatty acid hydroxylase gene (CpFAH) from Claviceps purpurea. In transgenic C. gracilis, RA content increased at low temperatures, reaching 2.2 pg/cell when cultured for 7 d at 15 °C, without affecting cell growth, and was enhanced (3...
November 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27829607/synthesis-of-novel-fatty-substituted-4-methyl-2hchromen-2-one-via-cross-metathesis-potential-antioxidants-and-chemotherapeutic-agents
#13
Vyshnavi Yelchuri, R B N Prasad, Mallampalli S L Karuna, Y Poornachandra, Chityal Ganesh Kumar
A series of novel fatty substituted 4-methyl-2H-chromen-2-one (coumarins) were synthesized by employing cross metathesis, a key step in the synthesis. The antioxidant activities of the title compounds were compared with the commercial antioxidants, namely butylated hydroxy toluene (BHT) and α-tocopherol, glycosidic and other substituted 4-methyl-2H-chromen-2-ones. Among the different 4-methyl-2H-chromen-2-ones, the glycosidic substituted 4-methyl-2H-chromen-2-ones was excellent, while those with aliphatic fatty acid chain and hydroxyl substitutents were good...
December 1, 2016: Journal of Oleo Science
https://www.readbyqxmd.com/read/27806561/4-hydroxy-7-oxo-5-heptenoic-acid-hoha-lactone-induces-angiogenesis-through-several-different-molecular-pathways
#14
Junhong Guo, Mikhail D Linetsky, Annabelle O Yu, Liang Zhang, Scott J Howell, Heather J Folkwein, Hua Wang, Robert G Salomon
Oxidative stress and angiogenesis have been implicated not only in normal phenomena such as tissue healing and remodeling but also in many pathological processes. However, the relationships between oxidative stress and angiogenesis still remain unclear, although oxidative stress has been convincingly demonstrated to influence the progression of angiogenesis under physiological and pathological conditions. The retina is particularly susceptible to oxidative stress owing to its intensive oxygenation and high abundance of polyunsaturated fatty acyls...
November 3, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27801287/designing-synthesis-and-antimicrobial-action-of-oxazoline-and-thiazoline-derivatives-of-fatty-acid-esters
#15
Anis Ahmad, Aiman Ahmad, Raja Sudhakar, Himani Varshney, Naidu Subbarao, Saba Ansari, Abdul Rauf, Asad U Khan
In this study, a novel series of oxazoline and thiazoline were designed as inhibitors of cytochrome P450 14 alpha-sterol demethylase (CYP51) from Candida albicans and peptide deformylase of Escherichia coli. The long chain dibromo derivative of fatty acid esters on reaction with urea and thiourea gave their corresponding oxazolines and thiazolines respectively. All the compounds were characterized by their spectral data (IR, (1)H NMR, (13)C NMR and MS) and tested for antibacterial and antifungal activity by disk diffusion assay and minimum inhibitory concentration (MIC) by the broth microdilution method against Gram-positive and Gram-negative strains of bacteria as well as fungus strains...
November 1, 2016: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/27791398/timing-of-glucocorticoid-administration-determines-severity-of-lipid-metabolism-and-behavioral-effects-in-rats
#16
Tao Wu, Jianguo Jiang, Luna Yang, Haifeng Li, Wanjing Zhang, Yangyang Chen, Binggong Zhao, Boda Kong, Ping Lu, Zhenzhen Zhao, Jiawei Zhu, Zhengwei Fu
Glucocorticoids (GCs) are a group of steroid hormones secreted by the adrenal glands in circadian cycles, and the dysregulation of GC signaling has been suggested to cause metabolic syndrome. Even though prolonged GC exposure is associated with serious side effects such as metabolic syndrome and central nervous system disorders, the use of GCs in anti-inflammatory and immunosuppressive therapies has been continuously rising. Meanwhile, the exact mechanisms by which GCs can influence the lipid metabolism as well as behavior and how they are affected by time remain unknown...
October 28, 2016: Chronobiology International
https://www.readbyqxmd.com/read/27789292/role-of-4-hydroxy-2-nonenal-hne-in-the-pathogenesis-of-alzheimer-disease-and-other-selected-age-related-neurodegenerative-disorders
#17
Fabio Di Domenico, Antonella Tramutola, D Allan Butterfield
Oxidative stress is involved in various and numerous pathological states including several age-related neurodegenerative diseases. Peroxidation of the membrane lipid bilayer is one of the major sources of free radical-mediated injury that directly damages neurons causing increased membrane rigidity, decreased activity of membrane-bound enzymes, impairment of membrane receptors and altered membrane permeability and eventual cell death. Moreover, the peroxidation of polyunsaturated fatty acids leads to the formation of aldehydes, which can act as toxic by-products...
October 24, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27789233/assessment-of-lipid-peroxidation-by-measuring-malondialdehyde-mda-and-relatives-in-biological-samples-analytical-and-biological-challenges
#18
Dimitrios Tsikas
Malondialdehyde (MDA), 4-hydroxy-nonenal (HNE) and the F2-isoprostane 15(S)-8-iso-prostaglandin F2α (15(S)-8-iso-PGF2α) are the best investigated products of lipid peroxidation. MDA, HNE and 15(S)-8-iso-PGF2α are produced from polyunsaturated fatty acids (PUFAs) both by chemical reactions by reactions catalyzed by enzymes. 15(S)-8-iso-PGF2α and other eicosanoid F2-isoprostanes are derived exclusively from arachidonic acid (AA). The number of PUFAs that may contribute to MDA and HNE is much higher. MDA is the prototype of the so called thiobarbituric acid reactive substances (TBARS)...
October 24, 2016: Analytical Biochemistry
https://www.readbyqxmd.com/read/27782100/isobutylhydroxyamides-from-zanthoxylum-bungeanum-and-their-suppression-of-no-production
#19
Yuan Wang, Chun-Huan Li, Bo Luo, Ya Nan Sun, Young Ho Kim, An-Zhi Wei, Jin-Ming Gao
Four new unsaturated aliphatic acid amides, named zanthoamides A-D (1-4), and eight known ones-tetrahydrobungeanool (5), ZP-amide A (6), ZP-amide B (7), ZP-amide C (8), ZP-amide D (9), ZP-amide E (10), bugeanumamide A (11), and (2E,7E,9E)-N-(2-hydroxy-2-methylpropyl)-6,11-dioxo-2,7,9-dodecatrienamide (12)-were isolated from the pericarps of Zanthoxylum bungeanum. The structures of these compounds were elucidated by extensive use of spectroscopic methods, including HRESIMS, 1D and 2D NMR analyses and comparison with previously reported data...
October 23, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27769381/confirmatory-and-quantitative-analysis-of-fatty-acid-esters-of-hydroxy-fatty-acids-in-serum-by-solid-phase-extraction-coupled-to-liquid-chromatography-tandem-mass-spectrometry
#20
María Asunción López-Bascón, Mónica Calderón-Santiago, Feliciano Priego-Capote
A novel class of endogenous mammalian lipids endowed with antidiabetic and anti-inflammatory properties has been recently discovered. These are fatty acid esters of hydroxy fatty acids (FAHFAs) formed by condensation between a hydroxy fatty acid and a fatty acid. FAHFAs are present in human serum and tissues at low nanomolar concentrations. Therefore, high sensitivity and selectivity profiling analysis of these compounds in clinical samples is demanded. An automated qualitative and quantitative method based on on-line coupling between solid phase extraction and liquid chromatography-tandem mass spectrometry has been here developed for determination of FAHFAs in serum with the required sensitivity and selectivity...
November 2, 2016: Analytica Chimica Acta
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