keyword
MENU ▼
Read by QxMD icon Read
search

hydroxy fatty acid

keyword
https://www.readbyqxmd.com/read/28209347/high-resolution-mass-spectrometry-based-method-applicable-for-a-wide-range-of-3-hydroxy-3-methyl-glutaryl-coenzyme-a-reductase-inhibitors-in-blood-serum-including-intermediates-and-products-of-the-cholesterol-biosynthetic-pathway
#1
Vít Kosek, Milena Stránská, Marie Fenclová, Tomáš Ruml, Libor Vítek, Jana Hajšlová
Statins belong to the major class of hypolipidemic drugs. They act as competitive inhibitors of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase, a rate-limiting enzyme in the cholesterol biosynthetic pathway. This inhibition not only leads to the depletion of cholesterol and its fatty acid esters, but also to the depletion of the intermediates of this metabolic pathway (mainly pyrophosphates), which can play an important role in tumor proliferation. The aim of the current study was to establish a versatile multi-analyte method capable of quantitative determination of various currently-used statins, together with free cholesterol (FC), cholesterol esters (CEs), and some key intermediates of the mevalonate pathway occurring in human serum...
January 31, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28202334/synthesis-of-specifically-deuterated-ceramide-ap-c18-and-its-biophysical-characterization-using-neutron-diffraction
#2
Stefan Sonnenberger, Adina Eichner, Thomas Hauß, Annett Schroeter, Reinhard H H Neubert, Bodo Dobner
The very heterogeneous group of ceramides is known to be mandatory for proper barrier functions of the outermost layer of mammalian skin, referred to as stratum corneum (SC). The synthesis of a specifically deuterated ceramide [AP]-C18 variant is described. The synthesized ceramide contains the racemic forms of the α hydroxy fatty acid. For the biophysical implementation, the received diastereomeric ceramide was applied in a neutron diffraction experiment. Therefore, a SC lipid model membrane was prepared containing the described ceramide (CER), cholesterol (CHOL), stearic acid (SA), and cholesterol sulfate (ChS) in a ratio of 55/25/15/5wt%...
February 12, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28192230/chemistry-and-analysis-of-hne-and-other-prominent-carbonyl-containing-lipid-oxidation-compounds
#3
REVIEW
Bebiana C Sousa, Andrew R Pitt, Corinne M Spickett
The process of lipid oxidation generates a diverse array of small aldehydes and carbonyl-containing compounds, which may occur in free form or esterified within phospholipids and cholesterol esters. These aldehydes mostly result from fragmentation of fatty acyl chains following radical oxidation, and the products can be subdivided into alkanals, alkenals (usually α,β-unsaturated), γ-substituted alkenals and bis-aldehydes. Isolevuglandins are non-fragmented di-carbonyl compounds derived from H2-isoprostanes, and oxidation of the ω-3-fatty acid docosahexenoic acid yield analogous 22 carbon neuroketals...
February 10, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28183232/triterpenoids-and-polysaccharide-peptides-enriched-ganoderma-lucidum-a-randomized-double-blind-placebo-controlled-crossover-study-of-its-antioxidation-and-hepatoprotective-efficacy-in-healthy-volunteers
#4
Hui-Fang Chiu, Hui-Yu Fu, Yan-Ying Lu, Yi-Chun Han, You-Cheng Shen, Kamesh Venkatakrishnan, Oksana Golovinskaia, Chin-Kun Wang
CONTEXT: Ganoderma lucidum (Leyss: Fr) Karst. (Polyporaceae) is an oriental medicinal fungus, commonly used in traditional Chinese medicine (TCM) for treating various condition or diseases such as hypertension, hyperglycaemia, hepatitis and cancer. OBJECTIVE: The current study examines whether triterpenoids and polysaccharide-enriched G. lucidum (GL) influence antioxidation and hepatoprotective efficacy by suppressing oxidative stress. MATERIALS AND METHODS: Forty-two healthy subjects (22 male and 20 female) were recruited and segregated into two groups as experimental or placebo and requested to intake GL (n = 21) or placebo (n = 21) capsule (225 mg; after lunch or dinner) for six consecutive months and vice versa with one month washout period in between...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28181382/selected-mutations-reveal-new-intermediates-in-the-biosynthesis-of-mupirocin-and-the-thiomarinol-antibiotics
#5
Shu-Shan Gao, Luoyi Wang, Zhongshu Song, Joanne Hothersall, Elton R Stevens, Jack Connolly, Peter J Winn, Russell J Cox, Matthew P Crump, Paul R Race, Christopher M Thomas, Thomas J Simpson, Christine L Willis
Thiomarinol and mupirocin are assembled on similar polyketide/fatty acid backbones and exhibit potent antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA). They both contain a tetrasubstituted tetrahydropyran (THP) ring that is essential for biological activity. Mupirocin is a mixture of pseudomonic acids (PAs). Isolation of the novel compound mupirocin P, which contains a 7-hydroxy-6-keto-substituted THP, from a ΔmupP strain and chemical complementation experiments confirm that the first step in the conversion of PA-B into the major product PA-A is oxidation at the C6 position...
February 9, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28172831/p045-5-aminosalicylates-promote-inflammation-resolution-in-ulcerative-colitis-through-generation-of-anti-inflammatory-hydroxy-fatty-acids
#6
R Wysoczanski, A Kendall, M Motwani, R Vega, F Rahman, S McCartney, S Bloom, A Nicolaou, D Gilroy, A Segal, D Marks
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28165385/quantitative-profiling-of-hydroxy-lipid-metabolites-in-mouse-organs-reveals-distinct-lipidomic-profiles-and-modifications-due-to-elevated-n-3-fatty-acid-levels
#7
Cheng-Ying Chiu, Christopher Smyl, Inci Dogan, Michael Rothe, Karsten-H Weylandt
Polyunsaturated fatty acids (PUFA) are precursors of bioactive metabolites and mediators. In this study, the profile of hydroxyeicosatetraenoic (HETE), hydroxyeicosapentaenoic (HEPE) and hydroxydocosahexaenoic (HDHA) acids derived from arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in colon, liver, lung, spleen, muscle, heart and kidney tissue of healthy wildtype mice were characterized, and compared to profiles in organs from transgenic fat-1 mice engineered to express the Caenorhabditis elegans fat-1 gene encoding an n-3 desaturase and thereby with endogenously elevated n-3 PUFA levels...
February 4, 2017: Biology
https://www.readbyqxmd.com/read/28161992/antrodia-cinnamomea-prevents-obesity-dyslipidemia-and-the-derived-fatty-liver-via-regulating-ampk-and-srebp-signaling
#8
Chiung-Huei Peng, Mon-Yuan Yang, Yi-Sun Yang, Chieh-Chou Yu, Chau-Jong Wang
Antrodia cinnamomea (AC), a protogenic fungus that only grows on the heartwood of endemic Cinnamomum kanehirae Hayata in Taiwan, is used to treat a variety of illness including liver disease. However, little is known about the benefit of AC against obesity and the related hepatic disorder. Using high-fat-diet (HFD) feed mice, we aimed to investigate whether the extract of AC (ACE) could reduce excessive weight, body fat, and serum lipids and prevent the development of non-alcoholic fatty liver (NAFLD). C57BL/6 mice were divided into five groups fed with different diets: control, HFD, and HFD with 0...
2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28157307/lipidomic-quantitation-of-oxidized-fatty-acids-in-plant-and-algae-oils
#9
Christine E Richardson, Marie Hennebelle, Yurika Otoki, Daisy Zamora, Jun Yang, Bruce D Hammock, Ameer Y Taha
Linoleic acid (LA) and alpha-linolenic acid (ALA) in plant or algae oils are precursors to oxidized fatty acid metabolites known as oxylipins. Liquid chromatography tandem mass spectrometry was used to quantify oxylipins in soybean, corn, olive, canola and four high-oleic acid algae oils at room temperature or after heating for 10 minutes at 100°C. Flaxseed oil oxylipin concentrations were determined in a follow-up experiment that compared it to soybean, canola, corn and olive oil. Published economic disappearance data for soybean, canola, corn and olive oil were used to estimate daily oxylipin intake...
February 3, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28155669/genome-wide-analysis-of-mrnas-associated-with-mouse-peroxisomes
#10
Aliaksandr A Yarmishyn, Maksym Kremenskoy, Arsen O Batagov, Axel Preuss, Jin Huei Wong, Igor V Kurochkin
BACKGROUND: RNA is often targeted to be localized to the specific subcellular compartments. Specific localization of mRNA is believed to be an important mechanism for targeting their protein products to the locations, where their function is required. RESULTS: In this study we performed the genome wide transcriptome analysis of peroxisome preparations from the mouse liver using microarrays. We demonstrate that RNA is absent inside peroxisomes, however it is associated at their exterior via the noncovalent contacts with the membrane proteins...
December 22, 2016: BMC Genomics
https://www.readbyqxmd.com/read/28153881/prevention-of-diet-induced-metabolic-dysregulation-inflammation-and-atherosclerosis-in-ldlr-mice-by-treatment-with-the-atp-citrate-lyase-inhibitor-bempedoic-acid
#11
Joshua P Samsoondar, Amy C Burke, Brian G Sutherland, Dawn E Telford, Cynthia G Sawyez, Jane Y Edwards, Stephen L Pinkosky, Roger S Newton, Murray W Huff
OBJECTIVE: Bempedoic acid (ETC-1002, 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid) is a novel low-density lipoprotein cholesterol-lowering compound. In animals, bempedoic acid targets the liver where it inhibits cholesterol and fatty acid synthesis through inhibition of ATP-citrate lyase and through activation of AMP-activated protein kinase. In this study, we tested the hypothesis that bempedoic acid would prevent diet-induced metabolic dysregulation, inflammation, and atherosclerosis...
February 2, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28143704/-22%C3%AE-25r-3%C3%AE-hydroxy-spirost-5-en-7-iminoxy-heptanoic-acid-exhibits-anti-prostate-cancer-activity-through-caspase-pathway
#12
A A Hamid, Tanu Kaushal, Raghib Ashraf, Arjun Singh, Amit Chand Gupta, Om Prakash, Jayanta Sarkar, Debabrata Chanda, D U Bawankule, Feroz Khan, Karuna Shanker, O O Aiyelaagbe, Arvind S Negi
Prostate cancer is one of the most common cancers in men. Diosgenin and related compounds are potential cytotoxic agents. Twelve diverse analogues of long chain fatty acid/ester of diosgenin-7-ketoxime have been prepared. Six of the analogues exhibited significant anticancer activity against a panel of human cancer cell lines with IC50 ranging from 12 to 35μM. Compound 16, the best representative of the series exerted S phase arrest in DU145 prostate cancer cells and induced apoptosis through caspase pathway...
January 28, 2017: Steroids
https://www.readbyqxmd.com/read/28123520/enhanced-expression-of-hydroxylated-ceramide-in-well-differentiated-endometrial-adenocarcinoma
#13
Toshiki Tajima, Masaki Miyazawa, Masaru Hayashi, Satoshi Asai, Masae Ikeda, Masako Shida, Takeshi Hirasawa, Masao Iwamori, Mikio Mikami
Based on our previous analysis of neutral glycolipids in the human endometrium, the present authors already reported that the concentrations of glucosylceramide, lactosylceramide and globotriaosylceramide (Gb3Cer), in which both fatty acids and sphingosines in the ceramides are hydroxylated, exhibit a marked increase during the luteal phase of the menstrual cycle. It is also well known that poorly differentiated endometrial adenocarcinoma exhibits a more rapid progression and a worse response to therapy than well-differentiated endometrial adenocarcinoma...
January 2017: Oncology Letters
https://www.readbyqxmd.com/read/28122665/expression-of-adenosine-5-monophosphate-activated-protein-kinase-ampk-in-ovine-testis-ovis-aries-in-vivo-regulation-by-nutritional-state
#14
N Taibi, J Dupont, Z Bouguermouh, P Froment, C Ramé, A Anane, Z Amirat, F Khammar
In the present study, we identified AMPK and investigated its potential role in steroidogenesis in vivo in the ovine testis in response to variation in nutritional status (fed control vs. restricted). We performed immunoblotting to show that both active and non-active forms of AMPK exist in ovine testis and liver. In testis, we confirmed these results by immunohistochemistry. We found a correlation between ATP (Adenosine-Triphosphate) levels and the expression of AMPK in liver. Also, low and high caloric diets induce isoform-dependent AMPK expression, with an increase in α2, ß1ß2 and γ1 activity levels...
January 19, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28118713/production-of-rare-phyto-ceramides-from-abundant-food-plant-residues
#15
Mathias Reisberg, Norbert Arnold, Andrea Porzel, Reinhard H H Neubert, Birgit Dräger
Ceramides (Cers) are major components of the outermost layer of the skin, the stratum corneum, and play a crucial role in permeability barrier functions. Alterations in Cer composition causing skin diseases are compensated with semisynthetic skin-identical Cers. Plants constitute new resources for Cer production as they contain glucosylceramides (GluCers) as major components. GluCers were purified from industrial waste plant materials, apple pomace (Malus domestica), wheat germs (Triticum sp.), and coffee grounds (Coffea sp...
February 13, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28109294/probing-the-intermolecular-interactions-of-ppar%C3%AE-lbd-with-polyunsaturated-fatty-acids-and-their-anti-inflammatory-metabolites-to-infer-most-potential-binding-moieties
#16
Shalini Muralikumar, Umashankar Vetrivel, Angayarkanni Narayanasamy, Undurti N Das
BACKGROUND: PPARγ is an isoform of peroxisome proliferator-activated receptor (PPAR) belonging to a super family of nuclear receptors. PPARγ receptor is found to play a crucial role in the modulation of lipid and glucose homeostasis. Its commotion has been reported to play a significant role in a broad spectrum of diseases such as type 2 diabetes mellitus, inflammatory diseases, Alzheimer's disease, and in some cancers. Hence, PPARγ is an important therapeutic target. Polyunsaturated fatty acids (PUFAs) and their metabolites (henceforth referred to as bioactive lipids) are known to function as agonists of PPARγ...
January 21, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28089927/metabolism-of-selective-20-epi-vitamin-d3-analogs-in-rat-osteosarcoma-umr-106-cells-isolation-and-identification-of-four-novel-c-1-fatty-acid-esters-of-1%C3%AE-25-dihydroxy-16-ene-20-epi-vitamin-d3
#17
Caroline Ceailles Flarakos, Andrew Weiskopf, Matthew Robinson, Guoshun Wang, Paul Vouros, Gino J Sasso, Milan R Uskokovic, G Satyanarayana Reddy
Analogs of 1α,25-dihydroxyvitamin D3 (S1) with 20-epi modification (20-epi analogs) possess unique biological properties. We previously reported that 1α,25-dihydroxy-20-epi-vitamin D3 (S2), the basic 20-epi analog is metabolized into less polar metabolites (LPMs) in rat osteosarcoma cells (UMR-106) but not in a perfused rat kidney. Furthermore, we also noted that only selective 20-epi analogs are metabolized into LPMs. For example, 1α,25-dihydroxy-16-ene-20-epi-vitamin D3 (S4), but not 1α,25-dihydroxy-16-ene-23-yne-20-epi-vitamin D3 (S5) is metabolized into LPMs...
January 12, 2017: Steroids
https://www.readbyqxmd.com/read/28087294/bioactive-metabolites-of-docosahexaenoic-acid
#18
REVIEW
Ondrej Kuda
Docosahexaenoic acid (DHA) is an essential fatty acid that is recognized as a beneficial dietary constituent and as a source of the anti-inflammatory specialized proresolving mediators (SPM): resolvins, protectins and maresins. Apart from SPMs, other metabolites of DHA also exert potent biological effects. This article summarizes current knowledge on the metabolic pathways involved in generation of DHA metabolites. Over 70 biologically active metabolites have been described, but are often discussed separately within specific research areas...
January 10, 2017: Biochimie
https://www.readbyqxmd.com/read/28071669/use-of-fibonacci-numbers-in-lipidomics-enumerating-various-classes-of-fatty-acids
#19
Stefan Schuster, Maximilian Fichtner, Severin Sasso
In lipid biochemistry, a fundamental question is how the potential number of fatty acids increases with their chain length. Here, we show that it grows according to the famous Fibonacci numbers when cis/trans isomerism is neglected. Since the ratio of two consecutive Fibonacci numbers tends to the Golden section, 1.618, organisms can increase fatty acid variability approximately by that factor per carbon atom invested. Moreover, we show that, under consideration of cis/trans isomerism and/or of modification by hydroxy and/or oxo groups, diversity can be described by generalized Fibonacci numbers (e...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28061412/nature-of-fly-ash-amendments-differently-influences-oxidative-stress-alleviation-in-four-forest-tree-species-and-metal-trace-element-phytostabilization-in-aged-contaminated-soil-a-long-term-field-experiment
#20
Sonia Labidi, Stéphane Firmin, Anthony Verdin, Géraldine Bidar, Frédéric Laruelle, Francis Douay, Pirouz Shirali, Joël Fontaine, Anissa Lounès-Hadj Sahraoui
Aided phytostabilization using coal fly ashes (CFAs) is an interesting technique to clean-up polluted soils and valorizing industrial wastes. In this context, our work aims to study the effect of two CFAs: silico-aluminous (CFA1) and sulfo-calcic (CFA2) ones, 10 years after their addition, on the phytostabilization of a highly Cd (cadmium), Pb (lead) and Zn (zinc) contaminated agricultural soil, with four forest tree species: Robinia pseudoacacia, Alnus glutinosa, Acer pseudoplatanus and Salix alba. To assess the effect of CFAs on trees, leaf fatty acid composition, malondialdehyde (MDA), oxidized and reduced glutathione contents ratio (GSSG: GSH), 8-hydroxy-2'-deoxyguanosine (8-OHdG), Peroxidase (PO) and Superoxide dismutase (SOD) activities were examined...
April 2017: Ecotoxicology and Environmental Safety
keyword
keyword
59942
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"