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Fernanda Viviane Mariano, Erika Said Egal, Dimitrius Pramio, Felipe Fidalgo, Érica Sara, Ana Flávia Costa, Rogério de Oliveira Gondak, Ricardo Della Coletta, Oslei Paes de Almeida, Luiz Paulo Kowalski, Ana Cristina Victorino Krepischi, Albina Altemani
OBJECTIVE: The progression of pleomorphic adenoma (PA) to carcinoma ex-pleomorphic adenoma (CXPA) encompasses several genomic alterations involving complex pathways. Tumor suppressor genes seem to play important roles in the tumorigenesis of both tumors. The aim of this study was to evaluate copy number and methylation of tumor suppressor genes' status in PA and CXPA samples. STUDY DESIGN: Eight cases of PA, 2 cases of residual PA in CXPA, and 5 cases of CXPA were studied; the latter were classified according to invasiveness and histopathological subtype...
September 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
M Cantile, R Franco, G Schiavo, A Procino, L Cindolo, G Botti, C Cillo
Genito-urinary malignancies (prostate, bladder, renal and testicular cancers) rank high among human tumors with an incidence that varies with age and organ involvement. Prostate cancer is the most commonly detected male cancer followed by bladder and kidney cancers, less frequent in women. Testicular cancer, although rare, is the most frequent cancer in males under 35. The majority of oncogenic and tumor suppressor signaling pathways involved with urogenital cancers converge on sets of transcription factors that ultimately control gene expression resulting in tumor formation and metastatic progression...
2011: Current Medicinal Chemistry
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