keyword
https://read.qxmd.com/read/38399787/a-dual-pharmacological-strategy-against-covid-19-the-therapeutic-potential-of-metformin-and-atorvastatin
#21
REVIEW
Luis Adrián De Jesús-González, Rosa María Del Ángel, Selvin Noé Palacios-Rápalo, Carlos Daniel Cordero-Rivera, Adrián Rodríguez-Carlos, Juan Valentin Trujillo-Paez, Carlos Noe Farfan-Morales, Juan Fidel Osuna-Ramos, José Manuel Reyes-Ruiz, Bruno Rivas-Santiago, Moisés León-Juárez, Ana Cristina García-Herrera, Adriana Clara Ramos-Cortes, Erika Alejandra López-Gándara, Estefanía Martínez-Rodríguez
Metformin (MET) and atorvastatin (ATO) are promising treatments for COVID-19. This review explores the potential of MET and ATO, commonly prescribed for diabetes and dyslipidemia, respectively, as versatile medicines against SARS-CoV-2. Due to their immunomodulatory and antiviral capabilities, as well as their cost-effectiveness and ubiquitous availability, they are highly suitable options for treating the virus. MET's effect extends beyond managing blood sugar, impacting pathways that can potentially decrease the severity and fatality rates linked with COVID-19...
February 13, 2024: Microorganisms
https://read.qxmd.com/read/38397657/task-sharing-and-remote-delivery-of-brief-interpersonal-counseling-for-venezuelan-migrants-and-refugees-living-in-peru-during-the-covid-19-pandemic-a-mixed-methods-pilot-study
#22
JOURNAL ARTICLE
M Claire Greene, Mayra Muro, Jeremy C Kane, Erin Young, Alejandra Paniagua-Avila, Lucy Miller-Suchet, Maria Nouel, Annie G Bonz, Maria Cristobal, Matthew Schojan, Peter Ventevogel, Bryan Cheng, Silvia S Martins, Jose Carlos Ponce de Leon, Helen Verdeli
Refugees and migrants experience an elevated risk for mental health problems and face significant barriers to receiving services. Interpersonal counseling (IPC-3) is a three-session intervention that can be delivered by non-specialists to provide psychological support and facilitate referrals for individuals in need of specialized care. We piloted IPC-3 delivered remotely by eight Venezuelan refugee and migrant women living in Peru. These counselors provided IPC-3 to Venezuelan refugee and migrant clients in Peru (n = 32) who reported psychological distress...
January 31, 2024: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/38373194/the-circadian-clock-and-thermal-regulation-in-plants-novel-findings-on-the-role-of-positive-circadian-clock-regulators-in-temperature-responses
#23
JOURNAL ARTICLE
María José de Leone, Marcelo Javier Yanovsky
The impact of rising global temperatures on crop yields is a serious concern, and developing heat-resistant crop varieties is crucial for mitigating the effects of climate change on agriculture. To achieve this, a better understanding of the molecular basis of the thermal responses in plants is necessary. The circadian clock plays a central role in modulating plant biology in synchrony with environmental changes including temperature fluctuations. Recent studies have uncovered the role of transcriptional activators of the core circadian network in temperature responses...
February 19, 2024: Journal of Experimental Botany
https://read.qxmd.com/read/38362021/from-imaging-to-precision-low-cost-and-accurate-determination-of-stereotactic-coordinates-for-brain-surgery-sapajus-apella-using-mri
#24
JOURNAL ARTICLE
Laís Resque Russo Pedrosa, Leon C P Leal, José Augusto P C Muniz, Caio de Oliveira Bastos, Bruno D Gomes, Lane V Krejcová
The capuchin monkey ( Sapajus apella ), a New World monkey species, exhibits prominent characteristics that make it an ideal model for neuroscience research. These characteristics include its phylogenetic traits, telencephalization coefficient, anatomical structures and pathways, genetic profile, immune responses, cognitive abilities, and complex behavioral repertoires. Traditionally, methodologies for stereotactic neurosurgery in research models have relied on the use of brain atlases. However, this approach can lead to errors due to the considerable variation in brain size and shape among individual monkeys...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38350940/health-impact-of-the-tajogaite-volcano-eruption-in-la-palma-population-isvolcan-study-rationale-design-and-preliminary-results-from-the-first-1002-participants
#25
JOURNAL ARTICLE
María Cristo Rodríguez-Pérez, Manuel Enrique Fuentes Ferrer, Luis D Boada, Ana Delia Afonso Pérez, María Carmen Daranas Aguilar, Jose Francisco Ferraz Jerónimo, Ignacio García Talavera, Luis Vizcaíno Gangotena, Arturo Hardisson de la Torre, Katherine Simbaña-Rivera, Antonio Cabrera de León
BACKGROUND: The eruption of the Tajogaite volcano began on the island of La Palma on September 19, 2021, lasting for 85 days. This study aims to present the design and methodology of the ISVOLCAN (Health Impact on the Population of La Palma due to the Volcanic Eruption) cohort, as well as the preliminary findings from the first 1002 enrolled participants. METHODS: A prospective cohort study was conducted with random selection of adult participants from the general population, with an estimated sample size of 2600 individuals...
February 13, 2024: Environmental Health
https://read.qxmd.com/read/38347443/spectrum-of-variants-associated-with-inherited-retinal-dystrophies-in-northeast-mexico
#26
JOURNAL ARTICLE
Rocio A Villafuerte-de la Cruz, Lucas A Garza-Garza, Manuel Garza-Leon, Cesar Rodriguez-De la Torre, Cinthya Parra-Bernal, Ilse Vazquez-Camas, David Ramos-Gonzalez, Andrea Rangel-Padilla, Angelina Espino Barros-Palau, Jose Nava-García, Javier Castillo-Velazquez, Erick Castillo-De Leon, Agustin Del Valle-Penella, Jorge E Valdez-Garcia, Augusto Rojas-Martinez
BACKGROUND: Inherited retinal dystrophies are hereditary diseases which have in common the progressive degeneration of photoreceptors. They are a group of diseases with clinical, genetic, and allelic heterogeneity. There is limited information regarding the genetic landscape of inherited retinal diseases in Mexico, therefore, the present study was conducted in the northeast region of the country. METHODS: Patients with inherited retinal dystrophies were included...
February 12, 2024: BMC Ophthalmology
https://read.qxmd.com/read/38346355/-mixed-adenoneuroendocrine-carcinoma-case-report
#27
JOURNAL ARTICLE
Ángel A Hernández-Moreno, Carlos E Durón-Gutiérrez, Sheyla P Serrano-González, Grettel León-Martínez, José G Arroyo-Del-Castillo
INTRODUCCIÓN: Mixed adenoneuroendocrine carcinoma is a rare tumor of the gastrointestinal tract with double differentiation into adenomatous and neuroendocrine carcinoma, each component with at least 30%. CASE REPORT: A 60-year-old female with acute abdominal pain. Surgical treatment was decided, finding a tumor at the level of the cecum and ascending colon, a right hemicolectomy and ileostomy were performed. DISCUSSION: Mixed adenoneuroendocrine carcinoma can appear in various organs...
February 12, 2024: Cirugia y Cirujanos
https://read.qxmd.com/read/38345224/disruption-of-the-mouse-blood-brain-barrier-by-small-extracellular-vesicles-from-hypoxic-human-placentas
#28
JOURNAL ARTICLE
Hermes Sandoval, José León, Felipe Troncoso, Valeria de la Hoz, Aaron Cisterna, Moisés Contreras, Fidel O Castro, Belén Ibañez, Jesenia Acurio, Carlos Escudero
Cerebrovascular complications, including cerebral edema and ischemic and hemorrhagic stroke, constitute the leading cause of maternal mortality associated with preeclampsia. The underlying mechanisms of these cerebrovascular complications remain unclear. However, they are linked to placental dysfunction and blood-brain barrier (BBB) disruption. Nevertheless, the connection between these two distant organs is still being determined. Increasing evidence suggests that the placenta releases signaling molecules, including extracellular vesicles, into maternal circulation...
January 26, 2024: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/38310744/population-structure-of-mycobacterium-tuberculosis-in-el-oro-a-first-insight-into-ecuador-peru-tuberculosis-transmission
#29
JOURNAL ARTICLE
Bernardo Castro-Rodriguez, Kerly León-Ordóñez, Greta Franco-Sotomayor, José Manuel Benítez-Medina, Natalia Jiménez-Pizarro, Greta Cárdenas-Franco, Juan Carlos Granda, Juan Luis Aguirre-Martínez, Solon Alberto Orlando, Javier Hermoso de Mendoza, Miguel Ángel García-Bereguiain
BACKGROUND: Tuberculosis (TB) is a major public health concern in Ecuador and Peru, both settings of high burden of drug resistance TB. Molecular epidemiology tools are important to understand the transmission dynamics of Mycobacterium tuberculosis Complex (MTBC) and to track active transmission clusters of regional importance. This study is the first to address the transmission of TB between Peru and Ecuador through the population structure of MTBC lineages circulating in the Ecuadorian border province of "El Oro"...
January 29, 2024: Journal of Infection and Public Health
https://read.qxmd.com/read/38291737/arsenic-lead-and-cadmium-concentration-in-food-and-estimated-daily-intake-in-the-cuban-population-and-the-health-risks-using-a-total-diet-study
#30
JOURNAL ARTICLE
Luisbel González-Pérez de Medina, Ociel Muñoz-Fariña, Yenisleidys Fernández-Guerrero, Analese Roman-Benn, José M Bastias-Montes, Roberto Quevedo-León, María Cristina Ravanal
This study estimates the intake of arsenic, lead and cadmium by the adult population (aged 18-91) of Cuba. The food consumption indices were obtained through 24-h dietary recall surveys applied to 450 people between October 2020 and March 2021. The Estimated Dietary Intake (EDI) of t-As (54.6 μg/day), Pb (118.5 μg/day) and Cd (35.1 μg/day) complied with Cuban legislation but was higher than the EDI for Cd established by the CONTAM Panel. The Target Hazard Quotients for the three contaminants were: iAs (0...
January 30, 2024: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://read.qxmd.com/read/38286697/description-of-maternal-and-neonatal-adverse-events-in-pregnant-people-immunised-with-covid-19-vaccines-during-pregnancy-in-the-clap-network-of-sentinel-sites-nested-case-control-analysis-of-the-immunization-associated-risk-a-study-protocol
#31
JOURNAL ARTICLE
Diego Macías Saint-Gerons, José Luis Castro, Mercedes Colomar, Edgard Rojas, Claudio Sosa, Alba Maria Ropero, Suzanne Jacob Serruya, Desiré Pastor, Monica Chiu, Martha Velandia-Gonzalez, Edgardo Abalos, Pablo Durán, Rodolfo Gomez Ponce de León, Giselle Tomasso, Luis Mainero, Marcelo Rubino, Bremen De Mucio
INTRODUCTION: COVID-19 is associated with higher morbimortality in pregnant people compared with non-pregnant people. At present, the benefits of maternal immunisation are considered to outweigh the risks, and therefore, vaccination is recommended during pregnancy. However, additional information is needed on the safety of the vaccines in this population. METHODS AND ANALYSIS: This a retrospective cohort nested case-control study in pregnant people who attended maternity hospitals from eight Latin American and Caribbean countries...
January 29, 2024: BMJ Open
https://read.qxmd.com/read/38275701/tracing-of-di-ethylhexyl-phthalate-in-the-tequila-production-process
#32
JOURNAL ARTICLE
Jose Tomas Ornelas-Salas, Juan Carlos Tapia-Picazo, Antonio De Leon-Rodriguez
The purpose of this study was to determine the origin, presence, and fate of the endocrine disruptor di-ethylhexil phthalate (DEHP) during tequila production. For this, three tequila factories (small, medium, and large) were monitored. DEHP concentrations in water, agave, additives, lubricating greases, neoprene seals, and materials of each stage process were analyzed using gas chromatography/mass spectrometry. DEHP mass balances were performed to identify the processes with significant changes in the inputs/outputs...
January 20, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38255117/comparative-analysis-of-the-impact-of-training-through-simulation-using-the-crisis-resource-management-tool-for-primary-care-professionals
#33
JOURNAL ARTICLE
Marta Bernardino-Santos, Daniel Arnal-Velasco, Pilar Reboto-Cortés, Cristina Garmendia-Fernandez, Esther Renilla-Sánchez, Ricardo Jose Navalón-Liceras, Elena Botillo-Pérez, Miguel A Ortega, Juan Ignacio Gómez-Arnau Díaz-Cañabate, Juan A De León-Luis
This was a prospective observational study based on clinical simulation courses taught in 2017 at the IDEhA Simulation Center of Alcorcón Foundation University Hospital. Two courses in metabolic emergencies (MEs) and respiratory emergencies (REs) were offered to primary care physicians all over Spain. The main objective was to teach nontechnical skills (crisis resource management). Using a modified five-level Kirkpatrick-Phillips education evaluation model, level I (reaction, K1), level II (learning, K2) and level III (behavioral change, K3) changes were evaluated through surveys at the end of the courses and one year later...
January 17, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38250901/a-potential-association-between-abdominal-obesity-and-the-efficacy-of-humoral-immunity-induced-by-covid-19-and-by-the-azd1222-convidecia-bnt162b2-sputnik-v-and-coronavac-vaccines
#34
JOURNAL ARTICLE
Javier Angeles-Martinez, Irma Eloisa Monroy-Muñoz, José Esteban Muñoz-Medina, Larissa Fernandes-Matano, Ángel Gustavo Salas-Lais, Ma De Los Ángeles Hernández-Cueto, Eyerahi Bravo-Flores, Moisés León-Juárez, Clara Esperanza Santacruz-Tinoco, Daniel Montes-Herrera
Abdominal obesity is highly prevalent in Mexico and has a poor prognosis in terms of the severity of coronavirus disease (COVID-19) and low levels of antibodies induced by infection and vaccination. We evaluated the humoral immune response induced by COVID-19 and five different vaccination schedules in Mexican individuals with abdominal obesity and the effects of other variables. This prospective longitudinal cohort study included 2084 samples from 389 participants. The levels of anti-S1/S2 and anti-RBD IgG antibodies were measured at various time points after vaccination...
January 15, 2024: Vaccines
https://read.qxmd.com/read/38248457/iodine-promotes-glucose-uptake-through-akt-phosphorylation-and-glut-4-in-adipocytes-but-higher-doses-induce-cytotoxic-effects-in-pancreatic-beta-cells
#35
JOURNAL ARTICLE
Reséndiz-Jiménez Arely, Arbez-Evangelista Cristian, Arroyo-Xochihua Omar, Palma-Jacinto José Antonio, Santiago-Roque Isela, De León-Ramírez Yeimy Mar, Hernández-Domínguez Xcaret Alexa, Arroyo-Helguera Omar
BACKGROUND: Epidemiological clinical reports have shown an association between iodine excess with diabetes mellitus type 2 and higher blood glucose. However, the relationship between iodine, the pancreas, adipose tissue, and glucose transport is unclear. The goal of this study was to analyze the effect of iodine concentrations (in Lugol solution) on glucose transport, insulin secretion, and its cytotoxic effects in mature 3T3-L1 adipocytes and pancreatic beta-TC-6 cells. METHODS: Fibroblast 3T3-L1, mature adipocytes, and pancreatic beta-TC-6 cells were treated with 1 to 1000 µM of Lugol (molecular iodine dissolved in potassium iodide) for 30 min to 24 h for an MTT proliferation assay...
January 1, 2024: Biology
https://read.qxmd.com/read/38248363/impact-of-non-surgical-periodontal-treatment-on-the-concentration-and-level-of-mrp-8-14-calprotectin-as-an-inflammatory-biomarker-in-women-with-periodontitis-and-rheumatoid-arthritis-a-quasi-experimental-study
#36
JOURNAL ARTICLE
Elena Aurora Popoca-Hernández, Rita Elizabeth Martínez-Martínez, Roberto Fidencio González-Amaro, Perla Del Carmen Niño-Moreno, José Luis Ayala-Herrera, Alberto Vinicio Jerezano-Domínguez, Leon Francisco Espinosa-Cristóbal, María de Lourdes Márquez-Corona, Irene Aurora Espinosa-de Santillana, Carlo Eduardo Medina-Solís
The aim of this study was to evaluate the impact of non-surgical periodontal treatment (NS-PT) on periodontal parameters and inflammatory biomarkers in the concentration and level of calprotectin (CLP) in women with periodontitis and rheumatoid arthritis (RA). In this quasi-experimental study, we evaluated 30 women (mean age: 52.0 ± 5.8 years) with periodontitis and RA who had been diagnosed and treated for RA for more than 3 years and whose activity markers remained at similar values without significant reduction over three consecutive months...
January 1, 2024: Diseases (Basel)
https://read.qxmd.com/read/38248268/on-the-cut-off-value-of-the-anteroposterior-diameter-of-the-midbrain-atrophy-in-spinocerebellar-ataxia-type-2-patients
#37
JOURNAL ARTICLE
José Alberto Álvarez-Cuesta, Camilo Mora-Batista, Ramón Reyes-Carreto, Frank Jesus Carrillo-Rodes, Sergio J Torralbaz Fitz, Yanetza González-Zaldivar, Cruz Vargas-De-León
(1) Background: Spinocerebellar ataxias (SCA) is a term that refers to a group of hereditary ataxias, which are neurological diseases characterized by degeneration of the cells that constitute the cerebellum. Studies suggest that magnetic resonance imaging (MRI) supports diagnoses of ataxias, and linear measurements of the aneteroposterior diameter of the midbrain (ADM) have been investigated using MRI. These measurements correspond to studies in spinocerebellar ataxia type 2 (SCA2) patients and in healthy subjects...
January 5, 2024: Brain Sciences
https://read.qxmd.com/read/38232277/in-vitro-characterization-of-a-novel-resin-based-restorative-material-containing-alkaline-fillers
#38
JOURNAL ARTICLE
Matias Mederos, Elisa de León, Andrés García, Carlos Enrique Cuevas-Suárez, Juan Carlos Hernández-Cabanillas, José Alejandro Rivera-Gonzaga, Guillermo Grazioli
OBJECTIVE: In this study, a comparative evaluation of the physicochemical properties of Cention N and other direct restorative materials was performed. Three restorative materials-a resin-modified glass ionomer (Fuji II LC), an alkasite-based resinous material (Cention N), and a resin composite (Tetric N Ceram)-were characterized in terms of degree of conversion, Knoop hardness number (KHN) ratio, flexural strength, elastic modulus, water sorption, water solubility, microshear bond strength to dentin, immediate microleakage, and radiopacity...
2024: Journal of Applied Oral Science: Revista FOB
https://read.qxmd.com/read/38226642/graft-versus-host-disease-after-an-outpatient-peripheral-blood-hematopoietic-cell-transplant-using-reduced-intensity-conditioning-a-single-center-latam-experience
#39
JOURNAL ARTICLE
José Carlos Jaime-Pérez, Jesús Daniel Meléndez-Flores, Jorge Valdespino-Valdes, Andrés Gómez-De León, Perla Rocío Colunga-Pedraza, César Homero Gutiérrez-Aguirre, Olga Graciela Cantú-Rodríguez, David Gómez-Almaguer
BACKGROUND: HLA compatibility predicts allogeneic hematopoietic cell transplant (allo-HCT) and graft-versus-host disease (GvHD) outcomes. There is insufficient information regarding GvHD outcomes for outpatient HLA-identical and haploidentical-HCT employing reduced-intensity conditioning (RIC). RESEARCH DESIGN AND METHODS: We compare GvHD outcomes between donor types and report risk factors associated with GvHD. Stem cell source was T-cell replete peripheral blood...
January 16, 2024: Expert Review of Hematology
https://read.qxmd.com/read/38218002/inflammatory-profiles-in-women-with-eating-disorder-linking-inflammatory-biomarkers-to-clinical-phenotypes
#40
JOURNAL ARTICLE
Marina Díaz-Marsá, Wala Ayad-Ahmed, José Manuel López-Villatoro, Verónica Fernández-Rodrigues, Francisco Ruiz-Guerrero, Andrés Gómez Del Barrio, Luis Beato-Fernández, Filomena Polo-Montes, Magdalena León-Velasco, Alejandro de la Torre-Luque, José Luis Carrasco, Javier R Caso, Karina S MacDowell, Juan C Leza
INTRODUCTION: Eating disorders (ED) represent a group of very complex and serious diagnoses characterized by emotional dysregulation and impulsivity. New approaches are necessary to achieve effective diagnosis and treatments. Shifting biomarker research away from the constraints of diagnostic categories may effectively contribute to a dimensional differentiation across disorders according to neurobiology (e.g., inflammatory biomarkers). Thus, the aim of our study was to identify inflammatory profiles in patients with ED...
January 3, 2024: Psychoneuroendocrinology
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