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https://www.readbyqxmd.com/read/28818396/identification-and-susceptibility-testing-of-candida-spp-directly-from-yeast-positive-blood-cultures-with-vitek-2
#1
María Fernanda González-Lara, Pedro Torres-González, Andrea Rangel-Cordero, José Sifuentes-Osornio, Alfredo Ponce-de-León, Areli Martínez-Gamboa
Culture-based identification and antifungal susceptibility take 48-72hours after positivity. We analyzed the performance of Vitek2 directly from 40 yeast-positive blood-cultures; agreement of 100% was observed for the tested antifungals; identification showed the same species in 31/40. The method reduces time (13 to 18h) for preliminary results.
July 14, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28810146/swarm-intelligence-enhanced-detection-of-non-small-cell-lung-cancer-using-tumor-educated-platelets
#2
Myron G Best, Nik Sol, Sjors G J G In 't Veld, Adrienne Vancura, Mirte Muller, Anna-Larissa N Niemeijer, Aniko V Fejes, Lee-Ann Tjon Kon Fat, Anna E Huis In 't Veld, Cyra Leurs, Tessa Y Le Large, Laura L Meijer, Irsan E Kooi, François Rustenburg, Pepijn Schellen, Heleen Verschueren, Edward Post, Laurine E Wedekind, Jillian Bracht, Michelle Esenkbrink, Leon Wils, Francesca Favaro, Jilian D Schoonhoven, Jihane Tannous, Hanne Meijers-Heijboer, Geert Kazemier, Elisa Giovannetti, Jaap C Reijneveld, Sander Idema, Joep Killestein, Michal Heger, Saskia C de Jager, Rolf T Urbanus, Imo E Hoefer, Gerard Pasterkamp, Christine Mannhalter, Jose Gomez-Arroyo, Harm-Jan Bogaard, David P Noske, W Peter Vandertop, Daan van den Broek, Bauke Ylstra, R Jonas A Nilsson, Pieter Wesseling, Niki Karachaliou, Rafael Rosell, Elizabeth Lee-Lewandrowski, Kent B Lewandrowski, Bakhos A Tannous, Adrianus J de Langen, Egbert F Smit, Michel M van den Heuvel, Thomas Wurdinger
Blood-based liquid biopsies, including tumor-educated blood platelets (TEPs), have emerged as promising biomarker sources for non-invasive detection of cancer. Here we demonstrate that particle-swarm optimization (PSO)-enhanced algorithms enable efficient selection of RNA biomarker panels from platelet RNA-sequencing libraries (n = 779). This resulted in accurate TEP-based detection of early- and late-stage non-small-cell lung cancer (n = 518 late-stage validation cohort, accuracy, 88%; AUC, 0.94; 95% CI, 0...
August 14, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28806082/the-discovery-of-novel-antimalarial-aminoxadiazoles-as-a-promising-nonendoperoxide-scaffold
#3
Elena Sandoval, María José Lafuente-Monasterio, María J Almela, Pablo Castañeda, María Belén Jiménez Díaz, María S Martínez-Martínez, Jaume Vidal, Íñigo Angulo-Barturen, Paul Bamborough, Jeremy Burrows, Nicholas Cammack, María J Chaparro, José M Coterón, Cristina de Cozar, Benigno Crespo, Beatriz Díaz, Gerard Drewes, Esther Fernández, Santiago Ferrer-Bazaga, María Teresa Fraile, Francisco J Gamo, Sonja Ghidelli-Disse, Rubén Gómez, John Haselden, Sophie Huss, María Luisa León, Jaime de Mercado, Simon J F Macdonald, José Ignacio Martín Hernando, Sara Prats, Margarita Puente, Anne Rodríguez, Juan C de la Rosa, Lourdes Rueda, Carolyn Selenski, Paul Willis, David M Wilson, Michael Witty, Félix Calderón
Since the appearance of resistance to the current front-line antimalarial treatments, ACTs (artemisinin combination therapies), the discovery of novel chemical entities to treat the disease is recognized as a major global health priority. From the GSK antimalarial set, we identified an aminoxadiazole with an antiparasitic profile comparable with artemisinin (1), with no cross-resistance in a resistant strains panel and a potential new mode of action. A medicinal chemistry program allowed delivery of compounds such as 19 with high solubility in aqueous media, an acceptable toxicological profile, and oral efficacy...
August 14, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28800094/socioeconomic-inequalities-in-visits-to-the-dentist-to-receive-professionally-applied-topical-fluoride-in-a-developing-country
#4
Miriam Del Socorro Herrera, Carlo Eduardo Medina-Solís, América Patricia Pontigo-Loyola, Rubén de la Rosa-Santillana, Leticia Ávila-Burgos, Rogelio José Scougall-Vilchis, Sonia Márquez-Rodríguez, Mirna Minaya-Sánchez, Alejandro José Casanova-Rosado
OBJECTIVE: To determine the frequency and associated factors of visits to the dentist in the last year by Nicaraguan schoolchildren to receive professionally applied topical fluoride (PATF). MATERIAL AND METHODS: A cross-sectional study was designed in children from public schools in the city of León, Nicaragua, were included. A series of socioeconomic, sociodemographic, and behavioural variables were collected through a questionnaire. The dependent variable was the visit to the dentist to receive professionally applied topical fluoride in the last year, which was dichotomised as (0) Did not receive PATF and (1) Yes received PATF...
August 11, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28799514/potentially-clinically-relevant-pharmacodynamic-interactions-between-antiepileptic-drugs-and-psychotropic-drugs-an-update
#5
Edoardo Spina, Jose de Leon
BACKGROUND: Prior articles paid little attention to pharmacodynamic drug interactions (DIs) between antiepileptic drugs (AEDs) and the most important psychotropic medications (antidepressants, antipsychotics, benzodiazepines and lithium) which have potential to be clinically relevant. OBJECTIVE: This article aims to provide an updated review of the potentially clinically relevant pharmacodynamic DIs between AEDs and psychotropic medications. Pharmacodynamic DIs take place directly at the site of action of a drug or indirectly by interfering with another physiological mechanism...
August 9, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28777033/pulmonary-embolism-during-stuporous-episodes-of-catatonia-was-found-to-be-the-most-frequent-cause-of-preventable-death-according-to-a-state-mortality-review-6-deaths-in-15-years
#6
Rocio Puentes, Allen Brenzel, Jose de Leon
Case reports have indicated that pulmonary embolism (PE) can be associated with deaths during episodes of catatonia. A 15-year death registry in Kentucky state psychiatric hospitals was reviewed for deaths during episodes of catatonia. From 2002 to May of 2016, reports of 96 deaths at these state psychiatric hospitals were found and reviewed by the state mortality committee. The charts of the identified catatonic patients were thoroughly reviewed. All 6 deaths occurred during episodes of what Fink and Taylor would call retarded catatonia and Ungvari would call acute stuporous catatonia...
August 4, 2017: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/28771611/inverse-association-of-resistin-with-physical-activity-in-the-general-population
#7
Itahisa Marcelino-Rodríguez, Delia Almeida Gonzalez, José Juan Alemán-Sánchez, Buenaventura Brito Díaz, María Del Cristo Rodríguez Pérez, Fadoua Gannar, Santiago Domínguez Coello, Francisco J Cuevas Fernández, Antonio Cabrera de León
AIM: Resistin is a cytokine related with inflammation and ischemic heart disease. Physical activity (PA) prevents chronic inflammation and ischemic heart disease. We studied the relationship of serum concentration of resistin with HDL cholesterol, a known biomarker of PA, and with different measures of PA, in a large sample of the general adult population in the Canary Islands. METHODS: Cross-sectional study of 6636 adults recruited randomly. We analyzed the correlation of resistin and HDL cholesterol with PA (as metabolic equivalent level [MET]), and fitted the results with linear and logistic regression models using adjustment for age, alcohol consumption and smoking...
2017: PloS One
https://www.readbyqxmd.com/read/28763072/-diagn%C3%A3-stico-tard%C3%A3-o-de-psoriasis-motivos-y-consecuencias
#8
José Carlos Quiroz-Vergara, Martha Alejandra Morales-Sánchez, Gonzalo Castillo-Rojas, Yolanda López-Vidal, María Luisa Peralta-Pedrero, Fermín Jurado-Santa Cruz, Samuel Ponce de León-Rosales
BACKGROUND: Psoriasis is an autoimmune skin disease that may be associated with articular manifestations, and the most common clinical presentation is the variety "in plaques". In Mexico, in the Centro Dermatológico Pascua, it is the eighth leading cause of consultation. The aim of this study was to determine the diagnostic process of patients in a reference center for diseases of the skin. METHODS: Performing an analytical cross-sectional study that included 100 patients where the diagnostic process was questioned, clinimetric scales were applied and evaluated anthropometric...
May 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28749528/confidence-intervals-for-omega-coefficient-proposal-for-calculus
#9
José Luis Ventura-León
La confiabilidad es entendida como una propiedad métrica de las puntuaciones de un instrumento de medida. Recientemente se viene utilizando el coeficiente omega (ω) para la estimación de la confiabilidad. No obstante, la medición nunca es exacta por la influencia del error aleatorio, por esa razón es necesario calcular y reportar el intervalo de confianza (IC) que permite encontrar en valor verdadero en un rango de medida. En ese contexto, el artículo plantea una forma de estimar el IC mediante el método de bootstrap para facilitar este procedimiento se brindan códigos de R (un software de acceso libre) para que puedan realizarse los cálculos de una forma amigable...
July 14, 2017: Adicciones
https://www.readbyqxmd.com/read/28744740/acute-cholangitis-after-bilioenteric-anastomosis-for-bile-duct-injuries
#10
Edgar Ortiz-Brizuela, José Sifuentes-Osornio, Daniel Manzur-Sandoval, Santiago Mier Y Terán-Ellis, Sergio Ponce-de-León, Pedro Torres-González, Miguel Ángel Mercado
BACKGROUND/PURPOSE: The study aims to describe the clinical features, microbiology, and associated factors of acute cholangitis (AC) after bilioenteric anastomosis (BEA) for biliary duct injury (BDI). Additionally, we assessed the performance of the Tokyo Guidelines 2013 (TG13) recommendations in these patients. METHODS: We conducted a case-control study of 524 adults with a history of BEA for BDI from January 2000 to January 2014. A propensity score adjustment was performed for the analysis of the independent role of the main factors identified during the univariate logistic regression procedure...
July 25, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28699847/a-systematic-review-and-combined-analysis-of-therapeutic-drug-monitoring-studies-for-long-acting-risperidone
#11
Georgios Schoretsanitis, Edoardo Spina, Christoph Hiemke, Jose de Leon
This systematic review of therapeutic drug monitoring (TDM) identifies three long-acting injectable (LAI) risperidone formulations. Areas covered: Limited data is available on two formulations (RBP-7000 and in Situ Microparticle), but 20 TDM articles on the microsphere formulation were found. Risperidone TDM includes the serum concentrations of risperidone and its active metabolite, 9-hydroxyrisperidone, used for calculating: 1) the risperidone/9-hydroxyrisperidone (R/9-OH-R) ratio (a measure of CYP2D6; values >1 are indicative of a CYP2D6 poor metabolizer) and 2) the total risperidone concentration-to-dose (C/D) ratio (a measure of risperidone clearance with a normal value around 7 in oral risperidone)...
July 12, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28698626/a-genome-wide-association-study-suggests-the-hla-class-ii-region-as-the-major-susceptibility-locus-for-iga-vasculitis
#12
Raquel López-Mejías, F David Carmona, Santos Castañeda, Fernanda Genre, Sara Remuzgo-Martínez, Belén Sevilla-Perez, Norberto Ortego-Centeno, Javier Llorca, Begoña Ubilla, Verónica Mijares, Trinitario Pina, José A Miranda-Filloy, Antonio Navas Parejo, Diego de Argila, Maximiliano Aragües, Esteban Rubio, Manuel León Luque, Juan María Blanco-Madrigal, Eva Galíndez-Aguirregoikoa, David Jayne, Ricardo Blanco, Javier Martín, Miguel A González-Gay
The genetic component of Immunoglobulin-A (IgA) vasculitis is still far to be elucidated. To increase the current knowledge on the genetic component of this vasculitis we performed the first genome-wide association study (GWAS) on this condition. 308 IgA vasculitis patients and 1,018 healthy controls from Spain were genotyped by Illumina HumanCore BeadChips. Imputation of GWAS data was performed using the 1000 Genomes Project Phase III dataset as reference panel. After quality control filters and GWAS imputation, 285 patients and 1,006 controls remained in the datasets and were included in further analysis...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28690819/molecular-genetic-analysis-of-two-native-desert-palm-genera-washingtonia-and-brahea-from-the-baja-california-peninsula-and-guadalupe-island
#13
Anastasia Klimova, Joseph I Hoffman, Jesus N Gutierrez-Rivera, Jose Leon de la Luz, Alfredo Ortega-Rubio
The complex geological and ecological processes that have generated high levels of biodiversity and endemism in the Baja California Peninsula have been the subject of intensive study. However, relatively little is known about phylogeography of the iconic endemic palm species of this region. We therefore analyzed a total of 2,294 bp of chloroplast and 738 bp of nuclear sequence data in 169 samples of five native palm species from Baja California, Sonora and Guadalupe Island. We found that Washingtonia and Brahea palms had low levels of genetic diversity and were highly structured, with the majority of species and major geographic regions being characterized by distinct haplotypes...
July 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28689002/age-acts-as-an-adverse-independent-variable-for-survival-in-acute-lymphoblastic-leukemia-data-from-a-cohort-in-northeast-mexico
#14
José Carlos Jaime-Pérez, Lucía Teresa Fernández, Raúl Alberto Jiménez-Castillo, Andrés Gómez-De León, Olga Graciela Cantú-Rodríguez, César Homero Gutiérrez-Aguirre, David Gómez-Almaguer
BACKGROUND: Survival for acute lymphoblastic leukemia (ALL) decreases with age. Patients across all age groups from a homogeneous ethnic and socioeconomic background were studied to document age effect. MATERIAL AND METHODS: Patients diagnosed from 2005 to 2015 at a university hospital in Northeast Mexico were divided into 4 age groups: infants (< 1), children (≥ 1 to < 16), adolescents (≥ 16 to ≤ 20), and adults (> 20 years). Correlation between age at diagnosis and relapse-free (RFS) and overall survival (OS) was investigated...
June 17, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28687461/further-evidence-for-major-repeaters-as-a-subgroup-of-suicide-attempters
#15
Maria Irigoyen-Otiñano, Margarita Puigdevall-Ruestes, Nuria Prades-Salvador, Sara Salort-Seguí, Lidia Gayubo, Jose de Leon, Hilario Blasco-Fontecilla
No abstract text is available yet for this article.
July 4, 2017: Revista de Psiquiatrí́a y Salud Mental
https://www.readbyqxmd.com/read/28676662/directing-the-self-assembly-of-tumour-spheroids-by-bioprinting-cellular-heterogeneous-models-within-alginate-gelatin-hydrogels
#16
Tao Jiang, Jose G Munguia-Lopez, Salvador Flores-Torres, Joel Grant, Sanahan Vijayakumar, Antonio De Leon-Rodriguez, Joseph M Kinsella
Human tumour progression is a dynamic process involving diverse biological and biochemical events such as genetic mutation and selection in addition to physical, chemical, and mechanical events occurring between cells and the tumour microenvironment. Using 3D bioprinting we have developed a method to embed MDA-MB-231 triple negative breast cancer cells, and IMR-90 fibroblast cells, within a cross-linked alginate/gelatin matrix at specific initial locations relative to each other. After 7 days of co-culture the MDA-MB-231 cells begin to form multicellular tumour spheroids (MCTS) that increase in size and frequency over time...
July 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28669680/hepatitis-c-virus-core-antigen-in-the-management-of-patients-treated-with-new-direct-acting-antivirals
#17
Juan Carlos Alados Arboledas, Inmaculada Pavón Guerrero, María José Blanco Rodríguez, Eva Torres Martos, Ana Belén Pérez, Cristina Cepero León, Jesus F Sierra Sánchez, María Dolores López Prieto, Natalia Chueca Porcuna, María Dolores Ocete Mochón, Juan Macías, Alberto de la Iglesia Salgado, Javier Rodríguez Granger, Marcial Delgado Fernández, Inmaculada Guerrero Lozano, Elena Reigadas Ramírez, Antonio Rivero, María Del Carmen Lozano Domínguez, Isabel Viciana, Juan Carlos Galán Montemayor, Federico García García
We evaluated the utility of Architect core antigen assay® Abbott Diagnostics (HCVAg) for monitoring patients with HCV infection and compared to HCV-RNA quantification (Cobas Ampliprep TaqMan-Roche Diagnostics). Samples from 262 patients were studied. Mean baseline HCV RNA and HCVAg levels were similar for responders (6.2 log IU/mL and 3.4 log fmol/L) and non-responders (6.1 log IU/mL and 3.2 log fmol/L), respectively. Only 10 patients failed to achieve SVR12 and all were detected by both assays. To evaluate HCVAg quantification as a tool for the detection of failure to DAAs, we performed a retrospective study of 132 non-responder patients...
June 17, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28669537/pneumonia-can-cause-clozapine-intoxication-a-case-report
#18
Can-Jun Ruan, Xue-Yang Zhen, Xin-Liang Ge, Chuan-Yue Wang, Wei Guo, Yi-Lang Tang, Wen-Biao Li, Jose de Leon
No abstract text is available yet for this article.
May 17, 2017: Psychosomatics
https://www.readbyqxmd.com/read/28657527/-behavior-of-predictive-variables-of-exacerbations-of-the-copd-in-the-neumological-hospital-of-cuba
#19
Yusbiel José León Valdivies, Reinaldo B Sánchez de la Osa, Eberto Garcia Silvera, Delfina Machado Molina, Liliana Oses Herrera
The use of predictive variables of exacerbations of the COPD is not a practice generalized in our environment, for what we cannot characterize the exacerbating patient neither to design strategies for its integral handling. There was carried out a prospective descriptive study to correlate in patient with diagnosis of COPD from the Neumologic Hospital of Cuba, with the objective of determining the association between clinical, functional variables and imagenological and the exacerbations frequency a year. The population was constituted for patients with clinical diagnosis of COPD and the sample for those patients with confirmed diagnosis that they completed the inclusion approaches...
2017: Revista de la Facultad de Ciencias Médicas
https://www.readbyqxmd.com/read/28652112/multinational-retrospective-case-control-study-of-risk-factors-for-the-development-of-late-invasive-pulmonary-aspergillosis-following-kidney-transplantation
#20
Francisco López-Medrano, Mario Fernández-Ruiz, José Tiago Silva, Peggy L Carver, Christian van Delden, Esperanza Merino, María José Pérez-Saez, Milagros Montero, Julien Coussement, Milene de Abreu Mazzolin, Carlos Cervera, Lidia Santos, Nuria Sabé, Anne Scemla, Elisa Cordero, Leónidas Cruzado-Vega, Paloma Leticia Martín-Moreno, Óscar Len, Eddison Rudas, Alfredo Ponce de León, Mariano Arriola, Ricardo Lauzurica, Miruna D David, Claudia González-Rico, Fernando Henríquez-Palop, Jesús Fortún, Marcio Nucci, Oriol Manuel, José Ramón Paño-Pardo, Miguel Montejo, Antonio Vena, Beatriz Sánchez-Sobrino, Auxiliadora Mazuecos, Julio Pascual, Juan Pablo Horcajada, Thanh Lecompte, Asunción Moreno, Jordi Carratalà, Marino Blanes, Domingo Hernández, Erick Alejandro Hernández-Méndez, María Carmen Fariñas, Manuel Perelló-Carrascosa, Patricia Muñoz, Amado Andrés, José María Aguado
OBJECTIVES: To assess the risk factors for the development of late-onset invasive pulmonary aspergillosis (IPA) after kidney transplantation (KT). METHODS: We performed a multinational case-control study that retrospectively recruited 112 KT recipients diagnosed with IPA between 2000 and 2013. Controls were matched (1:1 ratio) by center and date of transplantation. Immunosuppression-related events (IREs) included the occurrence of non-ventilator-associated pneumonia, tuberculosis, cytomegalovirus disease and/or de novo malignancy...
June 23, 2017: Clinical Microbiology and Infection
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