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https://www.readbyqxmd.com/read/27912128/time-to-grow-circadian-regulation-of-growth-and-metabolism-in-photosynthetic-organisms
#1
REVIEW
Santiago Mora-García, María José de Leone, Marcelo Yanovsky
Circadian clocks are molecular devices that help adjust organisms to periodic environmental changes. Although formally described as self-sustaining oscillators that are synchronized by external cues and produce defined outputs, it is increasingly clear that physiological processes not only are regulated by, but also regulate the function of the clock. We discuss three recent examples of the intimate relationships between the function of the clock, growth and metabolism in photosynthetic organisms: the daily tracking of sun by sunflowers, the fine computations plants and cyanobacteria perform to manage carbon reserves and prevent starvation, and the changes in clock parameters that went along with domestication of tomato...
November 29, 2016: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/27907067/incidence-mortality-and-positive-predictive-value-of-type-1-cardiorenal-syndrome-in-acute-coronary-syndrome
#2
Raquel Pimienta González, Patricia Couto Comba, Marcos Rodríguez Esteban, José Juan Alemán Sánchez, Julio Hernández Afonso, María Del Cristo Rodríguez Pérez, Itahisa Marcelino Rodríguez, Buenaventura Brito Díaz, Roberto Elosua, Antonio Cabrera de León
OBJECTIVES: To determine whether the risk of cardiovascular mortality associated with cardiorenal syndrome subtype 1 (CRS1) in patients who were hospitalized for acute coronary syndrome (ACS) was greater than the expected risk based on the sum of its components, to estimate the predictive value of CRS1, and to determine whether the severity of CRS1 worsens the prognosis. METHODS: Follow-up study of 1912 incident cases of ACS for 1 year after discharge. Cox regression models were estimated with time to event (in-hospital death, and readmission or death during the first year after discharge) as the dependent variable...
2016: PloS One
https://www.readbyqxmd.com/read/27895278/paracoccidioidomycosis-in-brazilian-patients-with-and-without-human-immunodeficiency-virus-infection
#3
Fabrício Arantes Almeida, Fernando Freitas Neves, Delio Jose Mora, Tarcisio Albertin Dos Reis, Diego Moelas Sotini, Barbara De Melo Ribeiro, Leonardo Eurípedes Andrade-Silva, Gabriel Nogueira Nascentes, Kennio Ferreira-Paim, Mario León Silva-Vergara
Paracoccidioidomycosis (PCM) is endemic to Latin America, where 10 million people may be infected with Paracoccidioides brasiliensis/Paracoccidioides lutzii and 1,600,000 individuals live with human immunodeficiency virus (HIV) infection. An epidemiological overlapping of these infections occurred early in acquired immunodeficiency syndrome era with nearly 180 published cases. This study presents epidemiological, clinical, and outcome profiles for 31 PCM/HIV-infected patients diagnosed in a teaching hospital in Brazil, and includes an update of previously reported cases...
November 28, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27872723/a-human-reproductive-approach-to-the-study-of-infertility-in-chimpanzees-an-experience-at-leon-s-zoological-park-mexico
#4
Raul Eduardo Piña-Aguilar, Janet López-Saucedo, Lilia Ivone Ruiz-Galaz, José de Jesús Barroso-Padilla, Mayra Celina Gallegos-Rivas, Claudia González-Ortega, Antonio Martin Gutiérrez-Gutiérrez
Great apes are mammals close to humans in their genetic, behavioral, social and evolutionary characteristics and new genomic information is revolutionizing our understanding of evolution in primates. However, all these species are endangered. While there are many global programs to protect these species, the International Union for Conservation of Nature (IUCN) projects that in a near future the wild populations will decrease significantly. Nowadays, the relevance of captive populations of great apes is becoming critical for research and understanding of pathophysiology of diseases...
2016: Veterinary Research Forum
https://www.readbyqxmd.com/read/27843115/de-novo-transcriptome-analysis-of-the-red-seaweed-gracilaria-chilensis-and-identification-of-linkers-associated-with-phycobilisomes
#5
María Alejandra Vorphal, Cristian Gallardo-Escárate, Valentina Valenzuela-Muñoz, Jorge Dagnino-Leone, José Aleikar Vásquez, José Martínez-Oyanedel, Marta Bunster
This work reports the results of the Illumina RNA-Seq of a wild population of female haploid plants of Gracilaria chilensis (Bird et al., 1986) (Rhodophyta, Gigartinalis). Most transcripts were de novo assembled in 12,331 contigs with an average length of 1756bp, showing that 96.64% of the sequences were annotated with known proteins. In particular, the identification of linker proteins of phycobilisomes (PBS) is reported. Linker proteins have primary been identified in cyanobacteria but the information available about them in eukaryotic red alga is not complete, and this is the first report in G...
November 11, 2016: Marine Genomics
https://www.readbyqxmd.com/read/27825312/human-tuberculosis-caused-by-mycobacterium-bovis-a-retrospective-comparison-with-mycobacterium-tuberculosis-in-a-mexican-tertiary-care-centre-2000-2015
#6
Pedro Torres-Gonzalez, Miguel E Cervera-Hernandez, Areli Martinez-Gamboa, Lourdes Garcia-Garcia, Luis P Cruz-Hervert, Miriam Bobadilla-Del Valle, Alfredo Ponce-de Leon, Jose Sifuentes-Osornio
BACKGROUND: Human tuberculosis caused by Mycobacterium bovis is believed to be frequent in developing countries. Transmission is usually through ingestion of unpasteurized dairy products, although airborne contagion is possible. Disease caused by M. tuberculosis or M. bovis is clinically indistinguishable from each other. The aim of this study was to determine the factors associated with M. bovis disease. METHODS: Retrospective analysis of all culture-positive cases of M...
November 8, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27812602/a-non-hepatotropic-parasite-infection-increases-mortality-in-the-acetaminophen-induced-acute-liver-failure-murine-model-possible-roles-for-il-5-and-il-6
#7
Marco A De León-Nava, Carolina Álvarez-Delgado, Luis Donis-Maturano, Joselin Hernández-Ruiz, Aaron N Manjarrez-Reyna, Edgar Cruz-Avilés, Sonia Leon-Cabrera, Jorge Morales-Montor, José M Fragoso, Galileo Escobedo
We evaluated the effects of a non-hepatotropic parasite infection (Taenia crassiceps) on the outcome of acetaminophen-induced acute liver failure in mice. Uninfected and T. crassiceps infected mice orally received either 300 mg/kg acetaminophen or water as vehicle (n = 5 per group). Survival analysis, hepatocyte necrosis, alanine aminotransferase (ALT) levels, CYP2E1 protein, interleukin (IL-) 5, and IL-6 were assessed for all groups. All infected mice died within 16 h after exposure to acetaminophen (Tc+APAP group), whereas only one-third of uninfected animals exposed to acetaminophen (APAP group) died...
October 31, 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27783366/laparoscopic-one-anastomosis-gastric-bypass-technique-results-and-long-term-follow-up-in-1200-patients
#8
Miguel A Carbajo, Enrique Luque-de-León, José M Jiménez, Javier Ortiz-de-Solórzano, Manuel Pérez-Miranda, María J Castro-Alija
BACKGROUND: Excellent results have been reported with mini-gastric bypass. We adopted and modified the one-anastomosis gastric bypass (OAGB) concept. Herein is our approach, results, and long-term follow-up (FU). METHODS: Initial 1200 patients submitted to laparoscopic OAGB between 2002 and 2008 were analyzed after a 6-12-year FU. Mean age was 43 years (12-74) and body mass index (BMI) 46 kg/m(2) (33-86). There were 697 (58 %) without previous or simultaneous abdominal operations, 273 (23 %) with previous, 203 (17 %) with simultaneous, and 27 (2 %) performed as revisions...
October 25, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27757082/clinical-relevance-of-specific-cognitive-complaints-in-determining-mild-cognitive-impairment-from-cognitively-normal-states-in-a-study-of-healthy-elderly-controls
#9
Marina Ávila-Villanueva, Ana Rebollo-Vázquez, José M Ruiz-Sánchez de León, Meritxell Valentí, Miguel Medina, Miguel A Fernández-Blázquez
Introduction: Subjective memory complaints (SMC) in the elderly have been suggested as an early sign of dementia. This study aims at investigating whether specific cognitive complaints are more useful than others to discriminate Mild Cognitive Impairment (MCI) by examining the dimensional structure of the Everyday Memory Questionnaire (EMQ). Materials and Methods: A sample of community-dwelling elderly individuals was recruited (766 controls and 78 MCI). The EMQ was administered to measure self-perception of cognitive complaints...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27755219/efficacy-and-safety-of-adjunctive-aripiprazole-in-schizophrenia-meta-analysis-of-randomized-controlled-trials
#10
Wei Zheng, Ying-Jun Zheng, Xian-Bin Li, Yi-Lang Tang, Chuan-Yue Wang, Ying-Qiang Xiang, Jose de Leon
This meta-analysis of randomized controlled trials (RCTs) evaluated the efficacy and safety of adding aripiprazole to other antipsychotics in schizophrenia. A systematic computer search identified 55 RCTs including 4457 patients who were randomized to aripiprazole (14.0 ± 7.0 mg/d) versus placebo (18 RCTs) or open antipsychotic treatment (37 RCTs). Aripiprazole significantly outperformed the comparison interventions based on psychiatric scales: (1) total score in 43 RCTs (N = 3351) with a standardized mean difference (SMD) of -0...
December 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27742477/acute-leukemia-characteristics-are-different-around-the-world-the-mexican-perspective
#11
David Gómez-Almaguer, Edson René Marcos-Ramírez, Efreen Horacio Montaño-Figueroa, Guillermo J Ruiz-Argüelles, Carlos Roberto Best-Aguilera, María Del Carmen López-Sánchez, Esperanza Barrera-Chairez, José Luis López-Arrollo, Christian Omar Ramos-Peñafiel, Andrés León-Peña, Elías Eugenio González-López, Perla Edith Rivas-García, Carlos Alberto Tellez-Hinojosa, Andrés Gómez-De León, José Carlos Jaime-Pérez
BACKGROUND: The incidence of acute leukemia (AL) has increased. Its prognosis is variable and depends on several baseline characteristics with a highly heterogeneous presentation. In Mexico, large-scale descriptive studies have not yet been published; the objective of this study was to analyze the initial basic characteristics of patients diagnosed with AL in our population. PATIENTS AND METHODS: In this multicenter, retrospective study, 1018 patients ≥ 16 years of age and diagnosed with AL between 2009 and 2014, were included...
September 17, 2016: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/27742265/-ebola-alert-results-and-challenges-in-public-health-a-view-from-catalonia-spain
#12
Mireia Jané, Mª José Vidal, Mar Maresma, Ana Martínez, Gloria Carmona, Ana Rodés, Nuria Torner, Josep Álvarez, Maria-Rosa Sala, Irene Barrabeig
The Ebola outbreak in Guinea Conakry was notified to the World Health Organization (WHO) in March 2014. It is the most complex Ebola outbreak to date, affecting Guinea Conakry as well as the surrounding countries and with a risk of the disease spreading outside Africa. For this reason, the World Health Organization declared this Ebola outbreak an international public health emergency in August 2014. The Public Health Agency of Catalonia, through the Spanish Alert and Emergencies Coordination Network, initiated public health actions in March 2014, developing a single protocol of action to be applied by all the health care providers in the whole Catalan territory, advice for travellers and voluntary workers arriving from affected countries and a weekly newsletter addressed to health professionals...
October 11, 2016: Gaceta Sanitaria
https://www.readbyqxmd.com/read/27726064/usefulness-of-molecular-markers-in-the-diagnosis-of-occupational-and-recreational-histoplasmosis-outbreaks
#13
María Guadalupe Frías-De-León, José Antonio Ramírez-Bárcenas, Gabriela Rodríguez-Arellanes, Oscar Velasco-Castrejón, Maria Lucia Taylor, María Del Rocío Reyes-Montes
Histoplasmosis is considered the most important systemic mycosis in Mexico, and its diagnosis requires fast and reliable methodologies. The present study evaluated the usefulness of PCR using Hcp100 and 1281-1283(220) molecular markers in detecting Histoplasma capsulatum in occupational and recreational outbreaks. Seven clinical serum samples of infected individuals from three different histoplasmosis outbreaks were processed by enzyme-linked immunosorbent assay (ELISA) to titre anti-H. capsulatum antibodies and to extract DNA...
October 10, 2016: Folia Microbiologica
https://www.readbyqxmd.com/read/27721781/pudendal-neuralgia-as-the-initial-manifestation-of-infiltrative-sacrococcygeal-chordoma
#14
Sira Carrasco García de León, José Manuel Flores Barragán, Natalia Villasanti Rivas
Sacrococcygeal chordoma is a malignant tumour originating from remnants of the notochord. Chordomas are slow-growing tumours whose symptoms develop insidiously. We present the case of a 72-year-old woman with a 6-month history of genital pain radiating to the perianal area and exacerbating when she was in a sitting position. MRI and PET studies revealed a large mass in the sacrococcygeal region causing bone destruction and invasion of neurovascular structures. The immunohistochemical study of the surgical specimen determined it to be chordoma...
May 2016: Case Reports in Neurology
https://www.readbyqxmd.com/read/27716766/-hydatid-cysts-in-pancreas-laparoscopic-approach
#15
Fernando Revoredo Rego, José De Vinatea De Cárdenas, Gustavo Reaño Paredes, Luis Villanueva Alegre, Fritz Kometter Barrios, Jorge Tang Sing, Mónica Uribe León, Landeo Italo Aliaga, José Arenas Gamio
: Hydatid disease is a parasitic infestation caused by Echinococcus and is endemic in many areas of the world. Hydatid cysts are commonly located in the liver and lung. Pancreas affection is very rare even in endemic areas. CASE REPORT: 36-year-old female with the suspicion of hydatid disease of the pancreas 5 years before her admission. The patient gave history of epigastric pain and weight lose. CT scan and MRI showed a cystic lesion of the tail of the pancreas and the diagnosis of hydatid disease was confirmed with ELIZA and Western Blot...
July 2016: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/27701748/effect-of-high-hydrostatic-pressure-on-the-polyphenols-and-antioxidant-activity-of-plantain-pulp-musa-paradisiaca-aab
#16
Miriam C Jiménez-Martínez, Efigenia Montalvo-González, Sonia G Sáyago-Ayerdi, Gilberto Mercado-Mercado, José A Ramírez-de León, Ernestina Paz-Gamboa, Maria A Vivar-Vera
BACKGROUND: The impact of high-pressure processing (HPP) on the polyphenol (PP) content and antioxidant activity (AOX) of plantain pulp was evaluated. Pressures of 400, 500 and 600 MPa were applied to plantain pulp for 90 and 180 s at room temperature (25 °C). Polyphenoloxidase activity, extractable (EPP) and non-extractable PP (NEPP) contents, flavonoid content and AOX (FRAP, ABTS(•+) ) were evaluated. In addition, PP identification was performed using high-performance liquid chromatography...
October 4, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27683101/an-amphotericin-b-derivative-equally-potent-to-amphotericin-b-and-with-increased-safety
#17
Armando Antillón, Alexander H de Vries, Marcel Espinosa-Caballero, José Marcos Falcón-González, David Flores Romero, Javier González-Damián, Fabiola Eloísa Jiménez-Montejo, Angel León-Buitimea, Manuel López-Ortiz, Ricardo Magaña, Siewert J Marrink, Rosmarbel Morales-Nava, Xavier Periole, Jorge Reyes-Esparza, Josué Rodríguez Lozada, Tania Minerva Santiago-Angelino, María Cristina Vargas González, Ignacio Regla, Mauricio Carrillo-Tripp, Mario Fernández-Zertuche, Lourdes Rodríguez-Fragoso, Iván Ortega-Blake
Amphotericin B is the most potent antimycotic known to date. However due to its large collateral toxicity, its use, although long standing, had been limited. Many attempts have been made to produce derivatives with reduced collateral damage. The molecular mechanism of polyene has also been closely studied for this purpose and understanding it would contribute to the development of safe derivatives. Our study examined polyene action, including chemical synthesis, electrophysiology, pharmacology, toxicology and molecular dynamics...
2016: PloS One
https://www.readbyqxmd.com/read/27660931/panlar-consensus-recommendations-for-the-management-in-osteoarthritis-of-hand-hip-and-knee
#18
Oscar Rillo, Humberto Riera, Carlota Acosta, Verónica Liendo, Joyce Bolaños, Ligia Monterola, Edgar Nieto, Rodolfo Arape, Luisa M Franco, Mariflor Vera, Silvia Papasidero, Rolando Espinosa, Jorge A Esquivel, Renee Souto, Cesar Rossi, José F Molina, José Salas, Francisco Ballesteros, Francisco Radrigan, Marlene Guibert, Gil Reyes, Araceli Chico, Walter Camacho, Lorena Urioste, Abraham Garcia, Isa Iraheta, Carmen E Gutierrez, Raúl Aragón, Margarita Duarte, Margarita Gonzalez, Oswaldo Castañeda, Juan Angulo, Ibsen Coimbra, Roberto Munoz-Louis, Ricardo Saenz, Carlos Vallejo, Julio Briceño, Ramón P Acuña, Anibal De León, Anthony M Reginato, Ingrid Möller, Carlo V Caballero, Maritza Quintero
OBJECTIVE: The objective of this consensus is to update the recommendations for the treatment of hand, hip, and knee osteoarthritis (OA) by agreeing on key propositions relating to the management of hand, hip, and knee OA, by identifying and critically appraising research evidence for the effectiveness of the treatments and by generating recommendations based on a combination of the available evidence and expert opinion of 18 countries of America. METHODS: Recommendations were developed by a group of 48 specialists of rheumatologists, members of other medical disciplines (orthopedics and physiatrists), and three patients, one for each location of OA...
October 2016: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/27647388/effect-of-graphene-oxide-on-bacteria-and-peripheral-blood-mononuclear-cells
#19
Jessica Campos-Delgado, Kelly L S Castro, Jose G Munguia-Lopez, Ana K González, Martin E Mendoza, Benjamin Fragneaud, Raphael Verdan, Joyce R Araujo, Francisco J González, Hugo Navarro-Contreras, Ivan N Pérez-Maldonado, Antonio de León-Rodríguez, Carlos A Achete
BACKGROUND: Driven by the potential biological applications of graphene, many groups have studied the response of cells exposed to graphene oxide (GO). In particular, investigations of bacteria indicate that there are 2 crucial parameters, which so far have only been investigated separately: GO size and exposure methodology. Our study took into account both parameters. We carefully characterized the samples to catalog sizes and structural properties, and tested different exposure methodologies: exposure in saline solution and in the presence of growth media...
September 7, 2016: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/27645148/primary-breast-cancer-cell-culture-yields-intra-tumor-heterogeneous-subpopulations-expressing-exclusive-patterns-of-receptor-tyrosine-kinases
#20
José Esparza-López, Pier A Ramos-Elías, Andrea Castro-Sánchez, Leticia Rocha-Zavaleta, Elizabeth Escobar-Arriaga, Alejandro Zentella-Dehesa, Eucario León-Rodríguez, Heriberto Medina-Franco, María de Jesus Ibarra-Sánchez
BACKGROUND: It has become evident that intra-tumor heterogeneity of breast cancer impact on several biological processes such as proliferation, migration, cell death and also might contribute to chemotherapy resistance. The expression of Receptor Tyrosine Kinases (RTKs) has not been analyzed in the context of intra-tumor heterogeneity in a primary breast cancer cell culture. Several subpopulations were isolated from the MBCDF (M serial-breast cancer ductal F line) primary breast cancer cells and were successfully maintained in culture and divided in two groups according to their morphology and RTKs expression pattern, and correlated with biological processes like proliferation, migration, anchorage-independent cell growth, and resistance to cytotoxic chemotherapy drugs and tyrosine kinase inhibitors (TKIs)...
2016: BMC Cancer
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