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https://www.readbyqxmd.com/read/28061377/tnf-%C3%AE-increases-in-the-csf-of-children-with-acute-lymphoblastic-leukemia-before-cns-relapse
#1
José Carlos Jaime-Pérez, Carmen Magdalena Gamboa-Alonso, Raúl Alberto Jiménez-Castillo, Leslie Jazmín López-Silva, Mónica Andrea Pinzón-Uresti, Andrés Gómez-De León, David Gómez-Almaguer
There is scarce information regarding the concentration of cytokines in cerebrospinal fluid (CSF) of children with acute lymphoblastic leukemia (ALL) and their clinical association with CNS status. A prospective analysis of 40 patients <18years with newly diagnosed ALL was performed. Human cytokine magnetic bead panel assay values of IL-2, IL-4, IL-6, IL-8, IL-10, MCP-1, TNF-α in CSF at diagnosis, end of induction to remission, and 6months after diagnosis were determined. IL-6 and MCP-1 values showed a significant increment at the end of induction...
December 23, 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28059677/hydrocephalus-in-a-patient-with-an-unruptured-pial-arteriovenous-fistula-hydrodynamic-considerations-endovascular-treatment-and-clinical-course
#2
Jesús A Morales-Gómez, Vicente V Garza-Oyervides, José A Arenas-Ruiz, Mariana Mercado-Flores, C Guillermo Elizondo-Riojas, Frederick A Boop, Ángel Martínez-Ponce de León
Intracranial pial arteriovenous fistulas, also known as nongalenic fistulas, are rare vascular malformations affecting predominantly the pediatric population. Hydrocephalus is an unusual presentation in which the exact pathophysiology is not fully understood. The aim of treatment in these cases is occlusion of the fistula prior to considering ventricular shunting. Here, the authors describe the hydrodynamic considerations of the paravascular pathway and the resolution of hydrocephalus with endovascular treatment of the fistula...
January 6, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28045753/nodules-on-the-hands
#3
Laura Berbegal, Jose C Pascual, Francisco J De Leon, Jaime Guijarro, Maria Niveiro
No abstract text is available yet for this article.
January 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28045751/nodules-on-the-hands-challenge
#4
Laura Berbegal, Jose C Pascual, Francisco J De Leon, Jaime Guijarro, Maria Niveiro
No abstract text is available yet for this article.
January 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28030600/isoniazid-mono-resistant-tuberculosis-impact-on-treatment-outcome-and-survival-of-pulmonary-tuberculosis-patients-in-southern-mexico-1995-2010
#5
Renata Báez-Saldaña, Guadalupe Delgado-Sánchez, Lourdes García-García, Luis Pablo Cruz-Hervert, Marlene Montesinos-Castillo, Leticia Ferreyra-Reyes, Miriam Bobadilla-Del-Valle, Sergio Canizales-Quintero, Elizabeth Ferreira-Guerrero, Norma Téllez-Vázquez, Rogelio Montero-Campos, Mercedes Yanes-Lane, Norma Mongua-Rodriguez, Rosa Areli Martínez-Gamboa, José Sifuentes-Osornio, Alfredo Ponce-de-León
BACKGROUND: Isoniazid mono-resistance (IMR) is the most common form of mono-resistance; its world prevalence is estimated to range between 0.0 to 9.5% globally. There is no consensus on how these patients should be treated. OBJECTIVE: To describe the impact of IMR tuberculosis (TB) on treatment outcome and survival among pulmonary TB patients treated under programmatic conditions in Orizaba, Veracruz, Mexico. MATERIALS AND METHODS: We conducted a prospective cohort study of pulmonary TB patients in Southern Mexico...
2016: PloS One
https://www.readbyqxmd.com/read/27992982/-prevalence-of-birth-defects-in-risaralda-2010-2013
#6
Gloria Liliana Porras-Hurtado, Olga Mercedes León-Castañeda, Jaime Molano-Hurtado, Sandra Lorena Quiceno, Harry Pachajoa, Juan José Montoya
INTRODUCTION: The data regarding birth defects at local levels in developing countries like Colombia are scarce. OBJECTIVE: To describe the profile of congenital abnormalities in the province of Risaralda, Colombia. MATERIALS AND METHODS: We included the information on infants with structural and functional abnormalities at birth between June, 2010, and December, 2013, from records of the Instituto Nacional de Salud, and compared it with those of children born in the same period in a local clinic participating in the Collaborative Study of Congenital Malformations...
December 1, 2016: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/27990836/practical-aspects-of-high-resolution-esophageal-manometry
#7
Antonio Ruiz de León San Juan, Constanza Ciriza de Los Ríos, Julio Pérez de la Serna Bueno, Fernando Canga Rodríguez-Valcárcel, Fermín Estremera Arévalo, Raquel García Sánchez, José Walter Huamán Ríos, María Teresa Pérez Fernández, Cecilio Santander Vaquero, Jordi Serra Pueyo, Concepción Sevilla Mantilla, Elisabeth Barba Orozco, María José Bosque López, Sergio Casabona Francés, Silvia Carrión Bolorino, Pilar Castillo Grau, Silvia Delgado Aros, Ana Belén Domínguez Carbajo, Pilar Fernández Orcajo, Javier García-Lledó, Froilán Gigantó Tomé, Rosa Iglesias Picazo, Gloria Lacima Vidal, Pilar López López, Magdalena Llabrés Rosselló, Pilar Mas Mercader, Marianela Mego Silva, María Usua Mendarte Barrenetxea, Carlos Miliani Molina, Milagros Oreja Arrayago, Francisco Sánchez Ceballos, Sandra Sánchez Prudencio
High resolution esophageal manometry (HRM) is currently under development as can be seen in the various Chicago classifications. In order to standardize criteria in certain practical aspects with limited scientific evidence, the First National Meeting for Consensus in High Resolution Manometry of the Spanish Digestive Motility Group took place, bringing together a wide group of experts. The proposals were based on a prior survey composed of 47 questions, an exhaustive review of the available literature and the experience of the participants...
December 19, 2016: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/27988223/mexican-registry-of-pulmonary-hypertension-remehip-registro-mexicano-de-hipertensi%C3%A3-n-pulmonar
#8
Julio Sandoval Zarate, Carlos Jerjes-Sanchez, Alicia Ramirez-Rivera, Tomas Pulido Zamudio, Pedro Gutierrez-Fajardo, Jose Elizalde Gonzalez, Mario Seoane Garcia De Leon, Miguel Beltran Gamez, Francisco Moreno Hoyos Abril, Rodolfo Parra Michel, Humberto Garcia Aguilar
OBJECTIVE: REMEHIP is a prospective, multicentre registry on pulmonary hypertension. The main objective will be to identify the clinical profile, medical care, therapeutic trends and outcomes in adult and pediatric Mexican patients with well-characterized pulmonary hypertension. METHODS: REMEHIP a multicenter registry began in 2015 with a planned recruitment time of 12 months and a 4-year follow-up. The study population will comprise a longitudinal cohort study, collecting data on patients with prevalent and incident pulmonary hypertension...
December 14, 2016: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/27977122/comparative-analysis-of-the-neurochemical-profile-and-mao-inhibition-properties-of-n-furan-2-ylmethyl-n-methylprop-2-yn-1-amine
#9
Philippe De Deurwaerdère, Claudia Binda, Rémi Corne, Cosima Leone, Aurora Valeri, Massimo Valoti, Rona R Ramsay, Yagamare Fall, José Marco-Contelles
The regulation of brain monoamine levels is paramount for cognitive functions, and the monoamine oxidase (MAO A and B) enzymes play a central role in these processes. The aim of this study was to evaluate whether the procognitive properties exerted by propargylamine N-(furan-2-ylmethyl)-N-methylprop-2-yn-1-amine (F2MPA) are related to changes in monoamine content via MAO inhibition. In vivo microdialysis and ex vivo amine metabolite measurement demonstrated region-specific alterations in monoamine metabolism that differ from both of the classic MAO A and MAO B inhibitors, clorgyline and l-deprenyl, respectively...
December 30, 2016: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/27967291/novel-hypoglycemia-phenotype-in-congenital-hyperinsulinism-due-to-dominant-mutations-of-uncoupling-protein-2-ucp2
#10
Christine T Ferrara, Kara E Boodhansingh, Elenora Paradies, Fiermonte Giuseppe, Linda J Steinkrauss, Lisa Swartz Topor, Jose Bernardo Quintos, Arupa Ganguly, Diva D De Leon, Ferdinando Palmieri, Charles A Stanley
CONTEXT: The rarest genetic form of congenital hyperinsulinism (HI) has been associated with dominant inactivating mutations in uncoupling protein 2 (UCP2), a mitochondrial inner membrane carrier that modulates the oxidation of glucose vs amino acids. OBJECTIVE: To evaluate the frequency of UCP2 mutations in children with HI and phenotypic features of this form of HI. DESIGN: We examined 211 children with diazoxide-responsive HI seen at The Children's Hospital of Philadelphia (CHOP) between 1997 and October 2016...
December 14, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27951745/studies-on-phytochemical-antioxidant-anti-inflammatory-hypoglycaemic-and-antiproliferative-activities-of-echinacea-purpurea-and-echinacea-angustifolia-extracts
#11
Rayn Clarenc Aarland, Angel Ernesto Bañuelos-Hernández, Mabel Fragoso-Serrano, Edgar Del Carmen Sierra-Palacios, Fernando Díaz de León-Sánchez, Laura Josefina Pérez-Flores, Fernando Rivera-Cabrera, José Alberto Mendoza-Espinoza
CONTEXT: Echinacea (Asteraceae) is used because of its pharmacological properties. However, there are few studies that integrate phytochemical analyses with pharmacological effects. OBJECTIVE: Evaluate the chemical profile and biological activity of hydroalcoholic Echinacea extracts. MATERIALS AND METHODS: Density, dry matter, phenols (Folin-Ciocalteu method), flavonoids (AlCl3 method), alkylamides (GC-MS analysis), antioxidant capacity (DPPH and ABTS methods), antiproliferative effect (SRB assay), anti-inflammatory effect (paw oedema assay, 11 days/Wistar rats; 0...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27912128/time-to-grow-circadian-regulation-of-growth-and-metabolism-in-photosynthetic-organisms
#12
REVIEW
Santiago Mora-García, María José de Leone, Marcelo Yanovsky
Circadian clocks are molecular devices that help adjust organisms to periodic environmental changes. Although formally described as self-sustaining oscillators that are synchronized by external cues and produce defined outputs, it is increasingly clear that physiological processes not only are regulated by, but also regulate the function of the clock. We discuss three recent examples of the intimate relationships between the function of the clock, growth and metabolism in photosynthetic organisms: the daily tracking of sun by sunflowers, the fine computations plants and cyanobacteria perform to manage carbon reserves and prevent starvation, and the changes in clock parameters that went along with domestication of tomato...
November 29, 2016: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/27907067/incidence-mortality-and-positive-predictive-value-of-type-1-cardiorenal-syndrome-in-acute-coronary-syndrome
#13
Raquel Pimienta González, Patricia Couto Comba, Marcos Rodríguez Esteban, José Juan Alemán Sánchez, Julio Hernández Afonso, María Del Cristo Rodríguez Pérez, Itahisa Marcelino Rodríguez, Buenaventura Brito Díaz, Roberto Elosua, Antonio Cabrera de León
OBJECTIVES: To determine whether the risk of cardiovascular mortality associated with cardiorenal syndrome subtype 1 (CRS1) in patients who were hospitalized for acute coronary syndrome (ACS) was greater than the expected risk based on the sum of its components, to estimate the predictive value of CRS1, and to determine whether the severity of CRS1 worsens the prognosis. METHODS: Follow-up study of 1912 incident cases of ACS for 1 year after discharge. Cox regression models were estimated with time to event (in-hospital death, and readmission or death during the first year after discharge) as the dependent variable...
2016: PloS One
https://www.readbyqxmd.com/read/27895278/paracoccidioidomycosis-in-brazilian-patients-with-and-without-human-immunodeficiency-virus-infection
#14
Fabrício Arantes Almeida, Fernando Freitas Neves, Delio Jose Mora, Tarcisio Albertin Dos Reis, Diego Moelas Sotini, Barbara De Melo Ribeiro, Leonardo Eurípedes Andrade-Silva, Gabriel Nogueira Nascentes, Kennio Ferreira-Paim, Mario León Silva-Vergara
Paracoccidioidomycosis (PCM) is endemic to Latin America, where 10 million people may be infected with Paracoccidioides brasiliensis/Paracoccidioides lutzii and 1,600,000 individuals live with human immunodeficiency virus (HIV) infection. An epidemiological overlapping of these infections occurred early in acquired immunodeficiency syndrome era with nearly 180 published cases. This study presents epidemiological, clinical, and outcome profiles for 31 PCM/HIV-infected patients diagnosed in a teaching hospital in Brazil, and includes an update of previously reported cases...
November 28, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27872723/a-human-reproductive-approach-to-the-study-of-infertility-in-chimpanzees-an-experience-at-leon-s-zoological-park-mexico
#15
Raul Eduardo Piña-Aguilar, Janet López-Saucedo, Lilia Ivone Ruiz-Galaz, José de Jesús Barroso-Padilla, Mayra Celina Gallegos-Rivas, Claudia González-Ortega, Antonio Martin Gutiérrez-Gutiérrez
Great apes are mammals close to humans in their genetic, behavioral, social and evolutionary characteristics and new genomic information is revolutionizing our understanding of evolution in primates. However, all these species are endangered. While there are many global programs to protect these species, the International Union for Conservation of Nature (IUCN) projects that in a near future the wild populations will decrease significantly. Nowadays, the relevance of captive populations of great apes is becoming critical for research and understanding of pathophysiology of diseases...
2016: Veterinary Research Forum
https://www.readbyqxmd.com/read/27843115/de-novo-transcriptome-analysis-of-the-red-seaweed-gracilaria-chilensis-and-identification-of-linkers-associated-with-phycobilisomes
#16
María Alejandra Vorphal, Cristian Gallardo-Escárate, Valentina Valenzuela-Muñoz, Jorge Dagnino-Leone, José Aleikar Vásquez, José Martínez-Oyanedel, Marta Bunster
This work reports the results of the Illumina RNA-Seq of a wild population of female haploid plants of Gracilaria chilensis (Bird et al., 1986) (Rhodophyta, Gigartinalis). Most transcripts were de novo assembled in 12,331 contigs with an average length of 1756bp, showing that 96.64% of the sequences were annotated with known proteins. In particular, the identification of linker proteins of phycobilisomes (PBS) is reported. Linker proteins have primary been identified in cyanobacteria but the information available about them in eukaryotic red alga is not complete, and this is the first report in G...
November 11, 2016: Marine Genomics
https://www.readbyqxmd.com/read/27825312/human-tuberculosis-caused-by-mycobacterium-bovis-a-retrospective-comparison-with-mycobacterium-tuberculosis-in-a-mexican-tertiary-care-centre-2000-2015
#17
Pedro Torres-Gonzalez, Miguel E Cervera-Hernandez, Areli Martinez-Gamboa, Lourdes Garcia-Garcia, Luis P Cruz-Hervert, Miriam Bobadilla-Del Valle, Alfredo Ponce-de Leon, Jose Sifuentes-Osornio
BACKGROUND: Human tuberculosis caused by Mycobacterium bovis is believed to be frequent in developing countries. Transmission is usually through ingestion of unpasteurized dairy products, although airborne contagion is possible. Disease caused by M. tuberculosis or M. bovis is clinically indistinguishable from each other. The aim of this study was to determine the factors associated with M. bovis disease. METHODS: Retrospective analysis of all culture-positive cases of M...
November 8, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27812602/a-non-hepatotropic-parasite-infection-increases-mortality-in-the-acetaminophen-induced-acute-liver-failure-murine-model-possible-roles-for-il-5-and-il-6
#18
Marco A De León-Nava, Carolina Álvarez-Delgado, Luis Donis-Maturano, Joselin Hernández-Ruiz, Aaron N Manjarrez-Reyna, Edgar Cruz-Avilés, Sonia Leon-Cabrera, Jorge Morales-Montor, José M Fragoso, Galileo Escobedo
We evaluated the effects of a non-hepatotropic parasite infection (Taenia crassiceps) on the outcome of acetaminophen-induced acute liver failure in mice. Uninfected and T. crassiceps infected mice orally received either 300 mg/kg acetaminophen or water as vehicle (n = 5 per group). Survival analysis, hepatocyte necrosis, alanine aminotransferase (ALT) levels, CYP2E1 protein, interleukin (IL-) 5, and IL-6 were assessed for all groups. All infected mice died within 16 h after exposure to acetaminophen (Tc+APAP group), whereas only one-third of uninfected animals exposed to acetaminophen (APAP group) died...
December 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27783366/laparoscopic-one-anastomosis-gastric-bypass-technique-results-and-long-term-follow-up-in-1200-patients
#19
Miguel A Carbajo, Enrique Luque-de-León, José M Jiménez, Javier Ortiz-de-Solórzano, Manuel Pérez-Miranda, María J Castro-Alija
BACKGROUND: Excellent results have been reported with mini-gastric bypass. We adopted and modified the one-anastomosis gastric bypass (OAGB) concept. Herein is our approach, results, and long-term follow-up (FU). METHODS: Initial 1200 patients submitted to laparoscopic OAGB between 2002 and 2008 were analyzed after a 6-12-year FU. Mean age was 43 years (12-74) and body mass index (BMI) 46 kg/m(2) (33-86). There were 697 (58 %) without previous or simultaneous abdominal operations, 273 (23 %) with previous, 203 (17 %) with simultaneous, and 27 (2 %) performed as revisions...
October 25, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27757082/clinical-relevance-of-specific-cognitive-complaints-in-determining-mild-cognitive-impairment-from-cognitively-normal-states-in-a-study-of-healthy-elderly-controls
#20
Marina Ávila-Villanueva, Ana Rebollo-Vázquez, José M Ruiz-Sánchez de León, Meritxell Valentí, Miguel Medina, Miguel A Fernández-Blázquez
Introduction: Subjective memory complaints (SMC) in the elderly have been suggested as an early sign of dementia. This study aims at investigating whether specific cognitive complaints are more useful than others to discriminate Mild Cognitive Impairment (MCI) by examining the dimensional structure of the Everyday Memory Questionnaire (EMQ). Materials and Methods: A sample of community-dwelling elderly individuals was recruited (766 controls and 78 MCI). The EMQ was administered to measure self-perception of cognitive complaints...
2016: Frontiers in Aging Neuroscience
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