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https://www.readbyqxmd.com/read/28335754/the-structural-and-health-policy-environment-for-delivering-integrated-hiv-and-substance-use-disorder-treatments-in-puerto-rico
#1
Jared A Leff, Diana Hernández, Paul A Teixeira, Pedro C Castellón, Daniel J Feaster, Allan E Rodriguez, Jorge L Santana-Bagur, Sandra Miranda De León, José Vargas Vidot, Lisa R Metsch, Bruce R Schackman
BACKGROUND: HIV prevalence in Puerto Rico is nearly twice that of the mainland United States, a level that was substantially fueled by injection drug use. Puerto Rico has a longstanding history of health provision by the public sector that directly affects how HIV and substance use disorder (SUD) treatment services are provided and funded. As part of pre-implementation research for a randomized trial of a community-level intervention to enhance HIV care access for substance users in San Juan, Puerto Rico, we sought to understand the structural and health policy environment for providing HIV and SUD treatments...
March 23, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28321383/direct-endonasal-approach-with-partial-upper-posterior-septectomy-a-rescue-flap-technique-modification
#2
Arturo Sotomayor-González, Armando José Díaz-Martínez, Ramón Radillo-Gil, Everardo García-Estrada, Jesús Alberto Morales-Gómez, Isaac Jair Palacios-Ortiz, Samuel Pérez-Cárdenas, Mauricio Arteaga-Treviño, Ángel Martínez-Ponce De León
Objective Report a modification of the "rescue flap" technique using a direct endonasal approach with a partial superior septectomy for approaching pituitary tumors developed in our institution. Design Prospective study. Setting Hospital Universitario "Dr. José Eleuterio González," Universidad Autónoma de Nuevo León. Main Outcome Measures Since April 2015, we have performed 19 cases employing a direct endonasal approach with partial superior septectomy. Results and a technical note are described below...
April 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28291046/effectiveness-of-different-deep-dry-needling-dosages-in-the-treatment-of-patients-with-cervical-myofascial-pain-a-pilot-rct
#3
Josué Fernández-Carnero, Laura Gilarranz-de-Frutos, Jose Vicente León-Hernández, Daniel Pecos-Martin, Isabel Alguacil-Diego, Tomás Gallego-Izquierdo, Aitor Martín-Pintado-Zugasti
OBJECTIVE: To assess the effectiveness of different dosages of local twitch responses (LTRs) elicited by deep dry needling (DDN) in relation to pain intensity, pressure pain threshold (PPT), cervical range of movement (CROM), and disability degree in cervical myofascial pain patients. DESIGN: A randomized, double-blind clinical trial. PARTICIPANTS: Eighty-four patients (21 males, 63 females; 27.18 ± 10.91 yrs) with cervical pain. INTERVENTIONS: DDN in active myofascial trigger points (MTrPs) in the upper trapezius...
March 14, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28283575/interaction-of-a%C3%AE-oligomers-with-neurexin-2%C3%AE-and-neuroligin-1-mediates-synapse-damage-and-memory-loss-in-mice
#4
Jordano Brito-Moreira, Mychael V Lourenco, Mauricio M Oliveira, Juliana F S Vital, Felipe C Ribeiro, José Henrique Ledo, Luan P Diniz, Margaret H Magdesian, Helen M Melo, Fernanda Barros-Aragão, Jorge M de Souza, Soniza V Alves-Leon, Flavia C A Gomes, Julia R Clarke, Cláudia P Figueiredo, Fernanda G De Felice, Sergio T Ferreira
Brain accumulation of the amyloid-β protein (Aβ) and synapse loss are neuropathological hallmarks of Alzheimer disease (AD). Aβ oligomers (AβOs) are synaptotoxins that build up in the brains of patients and are thought to contribute to memory impairment in AD. Thus, identification of novel synaptic components that are targeted by AβOs will likely contribute to the elucidation of disease-relevant mechanisms. Trans-synaptic interactions between neurexins (Nrxs) and neuroligins (NLs) are essential for synapse structure, stability and function, and reduced NL levels have been recently associated with AD...
March 10, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28266901/collaborative-approach-of-individual-participant-data-of-prospective-studies-of-de-escalation-in-non-immunosuppressed-critically-ill-patients-with-sepsis
#5
Antonio Gutiérrez-Pizarraya, Marc Leone, Jose Garnacho-Montero, Claude Martin, Ignacio Martin-Loeches
BACKGROUND: There is a concern to conduct de-escalation in very sick patients. AIMS: To determine if de-escalation is feasible in ICU settings. METHODS: We performed a metaanalysis of published studies conducted comparing de-escalation (defined by withdrawal of at least one antimicrobial empirically prescribed, switch to a new antimicrobial with narrower spectrum and withdrawal of at least one antimicrobial plus change of another drug to a new one with narrower spectrum) in non-immunocompromised patients with sepsis admitted to ICU...
April 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28248445/prevalence-and-distribution-of-hepatitis-c-virus-genotypes-in-spain-during-the-2000-2015-period-the-gehep-005-study
#6
Antonio Aguilera, Daniel Navarro, Francisco Rodríguez Frias, Isabel Viciana, Ana María Martínez-Sapiña, Mario José Rodríguez, Elisa Martró, María Del Carmen Lozano, Eleda Coletta, Laura Cardeñoso, Avelina Suárez, Matilde Trigo, Javier Rodríguez-Granjer, Natalia Montiel, Alberto de la Iglesia, Juan Carlos Alados, Cesar Vegas, Samuel Bernal, Felipe Fernández-Cuenca, María José Pena, Gabriel Reina, Silvia García-Bujalance, María Julia Echevarria, Laura Benítez, Sonia Pérez-Castro, Dolores Ocete, Isabel García-Arata, Carmen Guerrero, Manuel Rodríguez-Iglesias, Paz Casas, Federico García
AIM: We report the largest study on the prevalence and distribution of HCV genotypes in Spain (2000-2015), and we relate them with clinical, epidemiological and virological factors. METHODS: Patients from 29 hospitals in 10 autonomous communities (Andalusia, Aragon, Castilla-Leon, Catalonia, Galicia, Canary Islands, Madrid-Community, Valencian-Community, Murcia Region and Basque Country) have been studied. Annual distribution of HCV genotypes and subtypes, as well as gender, age, transmission route, HIV and/or HBV-coinfection, and treatment details were recorded...
March 1, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28243038/the-role-of-flow-cytometry-in-celiac-disease-screening-using-human-leukocyte-antigen-in-adult-patients-with-type-1-diabetes-mellitus
#7
Miren Vicuña Arregui, Jose Manuel Zozaya Urmeneta, Helena León Brito, Juan Pablo Martínez De Esteban, Carlos Prieto Martínez, Lluis Forga Llenas, Erkuden Aranburu Urtasun, Francisco Sala Pericas, Ramón Angós Musgo, Maria Rosario Mercado Gutierrez, Mercedes Palacios Sarrasqueta
BACKGROUND: Patients with type 1 diabetes mellitus (DM1) have an increased risk of celiac disease (CD). Since CD can be seronegative, more sensible tests for detection are needed. In seronegative patients, CD diagnosis may be difficult because of a lack of specificity. Flow cytometry analysis of lymphocyte populations can be useful in this situation. We aimed to study the prevalence of CD in adult DM1 using human leukocyte antigen (HLA) compatibility-based screening. A secondary goal was to study the role of flow cytometry as a complementary tool in these patients...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/28238904/proteomic-toxicological-and-immunogenic-characterization-of-mexican-west-coast-rattlesnake-crotalus-basiliscus-venom-and-its-immunological-relatedness-with-the-venom-of-central-american-rattlesnake-crotalus-simus
#8
Álvaro Segura, María Herrera, Francisco Reta Mares, Claudia Jaime, Andrés Sánchez, Mariángela Vargas, Mauren Villalta, Aarón Gómez, José María Gutiérrez, Guillermo León
The venom of the Mexican west-coast rattlesnake (Crotalus basiliscus) was characterized for its protein composition, toxicological profile and immunogenic properties. This venom is composed of 68% Zn(2+)-dependent metalloproteinases (SVMPs), 14% phospholipases A2 (PLA2s), 11% serine proteinases, 4% SVMPs-inhibitor tripeptides (SVMP-ITs), 2% bradykinin-potentiating peptides (BPPs), 0.6% cysteine-rich secretory proteins (CRISPs), and 0.2% l-amino acid oxidases (LAAOs). SVMPs present in the venom are responsible for azocasein hydrolysis and hemorrhagic activity, but their contribution to the lethal activity of the venom in mice is masked by the neurotoxic activity of PLA2s, which in addition are also responsible for myotoxic activity...
February 24, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28229916/ongoing-nursing-training-influence-on-the-completion-of-electronic-pressure-ulcer-records
#9
María López, José María Jiménez, Isabel Peña, María José Cao, María Simarro, María José Castro
INTRODUCTION: Pressure ulcer (PU) care in nursing at the Hospital Clínico Universitario de Valladolid (HCUV) in Spain includes basic care and its registration through the electronic GACELA Care tool. To assess and evaluate the nursing intervention in PU evolution, a training programme was carried out to unify criteria on PU assessment, treatment, evaluation and monitoring. OBJECTIVE: To assess the influence of training on the completion of PU records in the GACELA Care application, and identify the level of satisfaction of the nurses after its use...
February 14, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28226327/measurements-of-catheter-venous-and-capillary-cyclosporine-a-blood-are-comparable-and-useful-in-pediatric-hematopoietic-stem-cell-transplant-recipients
#10
Oscar González-Llano, Consuelo Mancías-Guerra, Carmen Magdalena Gamboa-Alonso, Andrés Gómez-De León, José Carlos Jaime-Pérez, César Homero Gutiérrez-Aguirre, Olga Cantú-Rodríguez, Laura Villarreal-Martínez, Ricardo García-Sepulveda, Miguel Angel Herrera-Rojas, David Gómez-Almaguer
No abstract text is available yet for this article.
2017: Acta Haematologica
https://www.readbyqxmd.com/read/28183085/reviving-research-on-medication-attitudes-for-improving-pharmacotherapy-focusing-on-adherence
#11
REVIEW
Carlos De Las Cuevas, Jose de Leon
There is little current interest in research into patients' attitudes toward medications. In the 1960s, psychiatric researchers including Uhlenhuth, Rickels and Covi focused on this area, but this research topic needs to be revived in the 21st century. The Health Belief Model may hold potential for doing this. This model was initially developed by 2 health psychologists, Rosenstock and Becker, to explain why patients did not follow medical interventions. The application of this model to study medication adherence in psychiatric outpatients has provided multiple findings including the conclusions that adherence is associated with: (1) the balance between internal and external health control beliefs, (2) psychological reactance, (3) patients' attitudes toward prescribed drug treatment in general and (4) the balance between the necessity of taking medications versus the concerns derived from adverse drug reactions (ADRs)...
2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28166081/the-art-of-pharmacotherapy-reflections-on-pharmacophobia
#12
Jose de Leon, Carlos De Las Cuevas
PURPOSE/BACKGROUND: This commentary deals with the neglected issue of the art of psychopharmacology by recounting the authors' journeys. METHODS/PROCEDURES: First, a model of medical science situated within the history of medicine is described including (1) a limitation of the mathematical model of science, (2) the distinction between mechanistic science and mathematical science, (3) how this distinction is applied to medicine, and (4) how this distinction is applied to explain pharmacology to psychiatrists...
February 3, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28143509/a-protective-personal-factor-against-disability-and-dependence-in-the-elderly-an-ordinal-regression-analysis-with-nine-geographically-defined-samples-from-spain
#13
Javier Virues-Ortega, Saturio Vega, Manuel Seijo-Martinez, Pedro Saz, Fernanda Rodriguez, Angel Rodriguez-Laso, Susana Perez de Las Heras, Raimundo Mateos, Pablo Martinez-Martin, Ignacio Mahillo-Fernandez, Josep Garre-Olmo, Jordi Gascon, Francisco Jose Garcia-Garcia, Manuel Fernandez-Martinez, Felix Bermejo-Pareja, Alberto Bergareche, Julian Benito-Leon, Jesus de Pedro-Cuesta
BACKGROUND: Sense of Coherence (SOC) is defined as a tendency to perceive life experiences as comprehensible, manageable and meaningful. The construct is split in three major domains: Comprehensibility, Manageability, and Meaningfulness. SOC has been associated with successful coping strategies in the face of illness and traumatic events and is a predictor of self-reported and objective health in a variety of contexts. In the present study we aim to evaluate the association of SOC with disability and dependence in Spanish elders...
January 31, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28128812/the-2009-pandemic-in-mexico-experience-and-lessons-regarding-national-preparedness-policies-for-seasonal-and%C3%A2-epidemic-influenza
#14
Jose A Cordova-Villalobos, Alejandro E Macias, Mauricio Hernandez-Avila, Guillermo Dominguez-Cherit, Hugo Lopez-Gatell, Celia Alpuche-Aranda, Samuel Ponce de León-Rosales
Influenza is a viral respiratory disease capable of causing epidemics that represent a threat for global security. Mexico was the first country to notify the WHO of an outbreak of what later became the first influenza pandemic of the 21st Century, caused by the virus A(H1N1)2009. Before this event Mexico had a national pandemic influenza preparedness plan, which included seasonal influenza vaccination, stockpiles of personal protection equipment and strategic drugs, and risk communication strategies. During the epidemic, the national public health laboratory network and case surveillance systems were strengthened together with surge capacities for intensive care and delivery of antiviral drugs...
January 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28119279/effects-of-video-game-training-on-behavioral-and-electrophysiological-measures-of-attention-and-memory-protocol-for-a-randomized-controlled-trial
#15
Soledad Ballesteros, Julia Mayas, Eloisa Ruiz-Marquez, Antonio Prieto, Pilar Toril, Laura Ponce de Leon, Maria L de Ceballos, José Manuel Reales Avilés
BACKGROUND: Neuroplasticity-based approaches seem to offer promising ways of maintaining cognitive health in older adults and postponing the onset of cognitive decline symptoms. Although previous research suggests that training can produce transfer effects, this study was designed to overcome some limitations of previous studies by incorporating an active control group and the assessment of training expectations. OBJECTIVE: The main objectives of this study are (1) to evaluate the effects of a randomized computer-based intervention consisting of training older adults with nonaction video games on brain and cognitive functions that decline with age, including attention and spatial working memory, using behavioral measures and electrophysiological recordings (event-related potentials [ERPs]) just after training and after a 6-month no-contact period; (2) to explore whether motivation, engagement, or expectations might account for possible training-related improvements; and (3) to examine whether inflammatory mechanisms assessed with noninvasive measurement of C-reactive protein in saliva impair cognitive training-induced effects...
January 24, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28100304/iron-responsive-like-elements-in-the-parasite-entamoeba-histolytica
#16
Liliana Soto-Castro, Laura Yuliana Plata-Guzman, Elisa Elvira Figueroa-Angulo, Jaeson Calla-Choque, Magda Reyes-Lopez, Mireya DE LA Garza, Nidia Leon-Sicairos, Jose Antonio Garzon-Tiznado, Rossana Arroyo, Claudia Leon-Sicairos
In Entamoeba histolytica, iron modulates virulence and gene expression via unknown regulatory mechanisms. The existence of a posttranscriptional iron regulatory system parallel to the IRE/IRP (Iron-Responsive Element/Iron Regulatory Protein) system in the protozoan Trichomonas vaginalis has recently been reported. Due to their evolutionary closeness and the importance of iron for growth and virulence in these protozoa, we hypothesized the existence of an IRE/IRP-like mechanism in E. histolytica. To determine the presence of IRE-like elements in some mRNAs from this parasite, we performed in silico analyses of the 5'- and 3'-UTRs of mRNAs encoding virulence factors and cytoskeleton, ribosomal, and metabolism proteins...
January 18, 2017: Microbiology
https://www.readbyqxmd.com/read/28061377/tnf-%C3%AE-increases-in-the-csf-of-children-with-acute-lymphoblastic-leukemia-before-cns-relapse
#17
José Carlos Jaime-Pérez, Carmen Magdalena Gamboa-Alonso, Raúl Alberto Jiménez-Castillo, Leslie Jazmín López-Silva, Mónica Andrea Pinzón-Uresti, Andrés Gómez-De León, David Gómez-Almaguer
There is scarce information regarding the concentration of cytokines in cerebrospinal fluid (CSF) of children with acute lymphoblastic leukemia (ALL) and their clinical association with CNS status. A prospective analysis of 40 patients <18years with newly diagnosed ALL was performed. Human cytokine magnetic bead panel assay values of IL-2, IL-4, IL-6, IL-8, IL-10, MCP-1, TNF-α in CSF at diagnosis, end of induction to remission, and 6months after diagnosis were determined. IL-6 and MCP-1 values showed a significant increment at the end of induction...
December 23, 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28059677/hydrocephalus-in-a-patient-with-an-unruptured-pial-arteriovenous-fistula-hydrodynamic-considerations-endovascular-treatment-and-clinical-course
#18
Jesús A Morales-Gómez, Vicente V Garza-Oyervides, José A Arenas-Ruiz, Mariana Mercado-Flores, C Guillermo Elizondo-Riojas, Frederick A Boop, Ángel Martínez-Ponce de León
Intracranial pial arteriovenous fistulas, also known as nongalenic fistulas, are rare vascular malformations affecting predominantly the pediatric population. Hydrocephalus is an unusual presentation in which the exact pathophysiology is not fully understood. The aim of treatment in these cases is occlusion of the fistula prior to considering ventricular shunting. Here, the authors describe the hydrodynamic considerations of the paravascular pathway and the resolution of hydrocephalus with endovascular treatment of the fistula...
March 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28045753/nodules-on-the-hands
#19
Laura Berbegal, Jose C Pascual, Francisco J De Leon, Jaime Guijarro, Maria Niveiro
No abstract text is available yet for this article.
January 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28045751/nodules-on-the-hands-challenge
#20
Laura Berbegal, Jose C Pascual, Francisco J De Leon, Jaime Guijarro, Maria Niveiro
No abstract text is available yet for this article.
January 2017: American Journal of Dermatopathology
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