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https://www.readbyqxmd.com/read/28991356/antioxidant-capacity-in-vitro-and-in-vivo-of-various-ecotypes-of-mexican-plum-spondias-purpurea-l
#1
Juan Manuel Villa-Hernández, Gabriela Mendoza-Cardoso, José Alberto Mendoza-Espinoza, Cristián Vela-Hinojosa, Fernando Díaz de León-Sánchez, Fernando Rivera-Cabrera, Irán Alia-Tejacal, Laura J Pérez-Flores
Spondias purpurea L. is a fruit native to Mexico, however, it is found as far away as Brazil. It possesses a high commercial potential owing to its sensorial and nutritional qualities and its low cost of production. There exists a variety of ecotypes that have not been characterized and their adequate selection process, according to their strongest functional characteristics, will allow the establishment of improvement programs for this genetic resource. The object of this study was the chemical characterization and the determination of the in vitro and in vivo antioxidant capacity of 7 Spondias purpurea L...
October 9, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28986313/impact-of-clostridium-difficile-infection-caused-by-the-nap1-rt027-strain-in-severity-and-recurrence-during-an-outbreak-and-transition-to-endemicity-in-a-mexican-tertiary-care-center
#2
Karla María Tamez-Torres, Pedro Torres-González, Francisco Leal-Vega, Ariana García-Alderete, Norma Irene López García, Raquel Mendoza-Aguilar, Arturo Galindo-Fraga, Miriam Bobadilla-Del Valle, Alfredo Ponce de León, José Sifuentes-Osornio
OBJECTIVES: To describe the clinical characteristics, outcomes and factors associated with Clostridium difficile infection (CDI) due to the ribotype 027 (RT027) and recurrence, including an outbreak period, with transition to endemicity. METHOD: We performed a case-control study. We collected clinical and demographic data for patients with CDI from January 2008 to December 2015, performed ribotyping of isolates, and PCR for Toxin A, B, and binary. RESULTS: Among 324 CDI episodes, 27...
October 3, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28982173/induced-gamma-band-activity-from-eeg-as-a-possible-index-of-training-related-brain-plasticity-in-motor-tasks
#3
Carlos Amo, Luis De Santiago, Daniel Zarza Luciáñez, José Miguel León Alonso-Cortés, Miguel Alonso-Alonso, Rafael Barea, Luciano Boquete
The aim of this study was proposing gamma band activity (GBA) as an index of training-related brain plasticity in the motor cortex. Sixteen controls underwent an experimental session where electroencephalography (EEG) activity was recorded at baseline (resting) and during a motor task (hand movements). GBA was obtained from the EEG data at baseline and during the task. Index of plasticity (IP) was defined as the relationship between GBA at the end of the motor task (GBAM_FIN), divided by GBA at the beginning of the task (GBAM_INI) for movements of both hands...
2017: PloS One
https://www.readbyqxmd.com/read/28964416/the-prevalence-of-patient-prosthesis-mismatch-can-be-reduced-using-the-trifecta-aortic-prosthesis
#4
Daniel Hernandez-Vaquero, Rocio Diaz, Isaac Pascual, Jose Rozado, Jesus M De la Hera, Victor Leon, Pablo Avanzas, Maria Martín, Daniel García-Iglesias, David Calvo, Jacobo Silva, César Moris
BACKGROUND: Some important studies have shown that patient-prosthesis mismatch is a frequent occurrence after surgical aortic valve replacement that impairs survival. The Trifecta valve (St. Jude Medical Inc, St. Paul, MN) has special architecture designed to achieve the best hemodynamic profile. The aim of this study was to determine the prevalence of mismatch when using this prosthesis. METHODS: This study included 1,302 patients at 3 months postoperatively, 339 patients with a Trifecta prosthesis and 963 patients (the control group) with a Mitroflow aortic valve (Sorin Group Inc, Mitroflow Division, Vancouver, Canada)...
September 27, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28961801/influence-of-empirical-double-active-combination-antimicrobial-therapy-compared-with-active-monotherapy-on-mortality-in-patients-with-septic-shock-a-propensity-score-adjusted-and-matched-analysis
#5
Marco Ripa, Olga Rodríguez-Núñez, Celia Cardozo, Antonio Naharro-Abellán, Manel Almela, Francesc Marco, Laura Morata, Cristina De La Calle, Ana Del Rio, Carolina Garcia-Vidal, María Del Mar Ortega, María De Los Angeles Guerrero-León, Csaba Feher, Berta Torres, Pedro Puerta-Alcalde, Josep Mensa, Alex Soriano, José Antonio Martínez
Objectives: To evaluate the influence on mortality of empirical double-active combination antimicrobial therapy (DACT) compared with active monotherapy (AM) in septic shock patients. Methods: A retrospective study was performed of monomicrobial septic shock patients admitted to a university centre during 2010-15. A propensity score (PS) was calculated using a logistic regression model taking the assigned therapy as the dependent variable, and used as a covariate in multivariate analysis predicting 7, 15 and 30 day mortality and for matching patients who received DACT or AM...
August 31, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28922669/a-critical-commentary-on-the-2017-agnp-consensus-guidelines-for-therapeutic-drug-monitoring-in-neuropsychopharmacology
#6
Jose de Leon
In 2004, 2011, and 2017, the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP), a group of German-speaking psychiatric researchers and psychiatrists, published successive versions of therapeutic drug monitoring (TDM) expert group consensus guidelines. The 2017 version has as a major strength its encyclopedic nature, including 1358 references. The guideline has 3 major sections: 1) theoretical aspects of TDM, 2) drug concentration levels in blood to guide neuropsychopharmacotherapy, and 3) practical aspects of TDM in psychiatry and neurology...
September 18, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28902937/inside-out-and-standard-vein-grafts-associated-with-platelet-rich-plasma-prp-in-sciatic-nerve-repair-a-histomorphometric-study
#7
José Sidney Roque, Karina Torres Pomini, Rogério Leone Buchaim, Daniela Vieira Buchaim, Jesus Carlos Andreo, Domingos Donizeti Roque, Antonio de Castro Rodrigues, Geraldo Marco Rosa, Luis Henrique Rapucci Moraes, Fausto Viterbo
Purpose: To evaluated the tubulization technique with standard and inside-out vein, filled or not with platelet-rich plasma (PRP), in sciatic nerve repair. Methods: Seventy male Wistar rats were randomly divided into five groups: IOVNF (Inside-Out Vein with No Filling); IOVPRP (Inside-Out Vein filled with PRP); SVNF (Standard Vein with No Filling); SVPRP (Standard Vein filled with PRP); Sham (Control). The left external jugular vein was used as graft in a 10 mm nervous gap...
August 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28902922/molecular-clustering-of-patients-with-diabetes-and-pulmonary-tuberculosis-a-systematic-review-and-meta-analysis
#8
Francles Blanco-Guillot, Guadalupe Delgado-Sánchez, Norma Mongua-Rodríguez, Pablo Cruz-Hervert, Leticia Ferreyra-Reyes, Elizabeth Ferreira-Guerrero, Mercedes Yanes-Lane, Rogelio Montero-Campos, Miriam Bobadilla-Del-Valle, Pedro Torres-González, Alfredo Ponce-de-León, José Sifuentes-Osornio, Lourdes Garcia-Garcia
INTRODUCTION: Many studies have explored the relationship between diabetes mellitus (DM) and tuberculosis (TB) demonstrating increased risk of TB among patients with DM and poor prognosis of patients suffering from the association of DM/TB. Owing to a paucity of studies addressing this question, it remains unclear whether patients with DM and TB are more likely than TB patients without DM to be grouped into molecular clusters defined according to the genotype of the infecting Mycobacterium tuberculosis bacillus...
2017: PloS One
https://www.readbyqxmd.com/read/28902313/variables-associated-with-disordered-eating-behaviors-among-freshman-students-from-mexico-city
#9
Concepción Díaz de León-Vázquez, José Alberto Rivera-Márquez, Ietza Bojorquez-Chapela, Claudia Unikel-Santoncini
Objective: To estimate the prevalence of disordered eating behaviors (DEB) and identify their associations with demographic and psychological variables among freshman students at a public university in Mexico City. Materials and methods: A sample of 892 subjects participated in the study. Bivariate and multinomial models were performed to determine associations between DEB and covariates. Results: Of those surveyed, 6.8% of the women and 4...
May 2017: Salud Pública de México
https://www.readbyqxmd.com/read/28895541/financial-impact-of-disease-related-malnutrition-at-the-san-pedro-de-alc%C3%A3-ntara-hospital-estimated-cost-savings-associated-to-a-specialized-nutritional-survey
#10
Jesús Manuel Morán López, Fidel Jesús Enciso Izquierdo, Luis Miguel Luengo Pérez, Belén Beneítez Moralejo, María Piedra León, Daniel A de Luis, José Antonio Amado Señaris
INTRODUCTION AND OBJECTIVES: DRM is a highly prevalent condition in Spanish hospitals and is associated to increased healthcare costs. Costs associated to DRM were calculated using the methods of the PREDyCES study. The potential savings derived from specialized nutritional treatment were calculated by extrapolating the results of the SNAQ strategy. RESULTS: Median cost per procedure in patients with DRM was €9,679.85, with a final cost of €28,700,775.2. The cost of each patient with DRM was 2...
October 2017: Endocrinología, diabetes y nutrición
https://www.readbyqxmd.com/read/28891344/when-the-cure-is-the-risk-understanding-how-substance-use-affects-hiv-and-hcv-in-a-layered-risk-environment-in-san-juan-puerto-rico
#11
Diana Hernández, Pedro C Castellón, Yohansa Fernández, Francisco A Torres-Cardona, Carrigan Parish, Danielle Gorshein, Jose Vargas Vidot, Sandra Miranda de Leon, Allan Rodriguez, Jorge Santana Bagur, Daniel J Feaster, Bruce R Schackman, Lisa R Metsch
BACKGROUND: Substance use, particularly injection drug use, continues to fuel the HIV/HCV (hepatitis C virus) epidemics in San Juan, Puerto Rico (PR). AIM: This article examines individual and sociostructural factors that affect HIV/HCV risk among people who use drugs (PWUD) living with or at risk for HIV/HCV in San Juan, PR. Findings were used to inform a community-level intervention to enhance HIV care access and retention for this population. METHOD: A rapid ethnographic assessment in collaboration with a community-based organization was conducted...
September 1, 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/28864228/burkholderia-species-associated-with-legumes-of-chiapas-mexico-exhibit-stress-tolerance-and-growth-in-aromatic-compounds
#12
José A de León-Martínez, Gustavo Yañez-Ocampo, Arnoldo Wong-Villarreal
Leguminous plants have received special interest for the diversity of β-proteobacteria in their nodules and are promising candidates for biotechnological applications. In this study, 15 bacterial strains were isolated from the nodules of the following legumes: Indigofera thibaudiana, Mimosa diplotricha, Mimosa albida, Mimosa pigra, and Mimosa pudica, collected in 9 areas of Chiapas, Mexico. The strains were grouped into four profiles of genomic fingerprints through BOX-PCR and identified based on their morphology, API 20NE biochemical tests, sequencing of the 16S rRNA, nifH and nodC genes as bacteria of the Burkholderia genus, genetically related to Burkholderia phenoliruptrix, Burkholderia phymatum, Burkholderia sabiae, and Burkholderia tuberum...
August 29, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28860558/development-and-validation-of-a-multivariate-predictive-model-for-rheumatoid-arthritis-mortality-using-a-machine-learning-approach
#13
José M Lezcano-Valverde, Fernando Salazar, Leticia León, Esther Toledano, Juan A Jover, Benjamín Fernandez-Gutierrez, Eduardo Soudah, Isidoro González-Álvaro, Lydia Abasolo, Luis Rodriguez-Rodriguez
We developed and independently validated a rheumatoid arthritis (RA) mortality prediction model using the machine learning method Random Survival Forests (RSF). Two independent cohorts from Madrid (Spain) were used: the Hospital Clínico San Carlos RA Cohort (HCSC-RAC; training; 1,461 patients), and the Hospital Universitario de La Princesa Early Arthritis Register Longitudinal study (PEARL; validation; 280 patients). Demographic and clinical-related variables collected during the first two years after disease diagnosis were used...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818396/identification-and-susceptibility-testing-of-candida-spp-directly-from-yeast-positive-blood-cultures-with-vitek-2
#14
María Fernanda González-Lara, Pedro Torres-González, Andrea Rangel-Cordero, José Sifuentes-Osornio, Alfredo Ponce-de-León, Areli Martínez-Gamboa
Culture-based identification and antifungal susceptibility take 48-72hours after positivity. We analyzed the performance of Vitek2 directly from 40 yeast-positive blood-cultures; agreement of 100% was observed for the tested antifungals; identification showed the same species in 31/40. The method reduces time (13 to 18h) for preliminary results.
July 14, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28810146/swarm-intelligence-enhanced-detection-of-non-small-cell-lung-cancer-using-tumor-educated-platelets
#15
Myron G Best, Nik Sol, Sjors G J G In 't Veld, Adrienne Vancura, Mirte Muller, Anna-Larissa N Niemeijer, Aniko V Fejes, Lee-Ann Tjon Kon Fat, Anna E Huis In 't Veld, Cyra Leurs, Tessa Y Le Large, Laura L Meijer, Irsan E Kooi, François Rustenburg, Pepijn Schellen, Heleen Verschueren, Edward Post, Laurine E Wedekind, Jillian Bracht, Michelle Esenkbrink, Leon Wils, Francesca Favaro, Jilian D Schoonhoven, Jihane Tannous, Hanne Meijers-Heijboer, Geert Kazemier, Elisa Giovannetti, Jaap C Reijneveld, Sander Idema, Joep Killestein, Michal Heger, Saskia C de Jager, Rolf T Urbanus, Imo E Hoefer, Gerard Pasterkamp, Christine Mannhalter, Jose Gomez-Arroyo, Harm-Jan Bogaard, David P Noske, W Peter Vandertop, Daan van den Broek, Bauke Ylstra, R Jonas A Nilsson, Pieter Wesseling, Niki Karachaliou, Rafael Rosell, Elizabeth Lee-Lewandrowski, Kent B Lewandrowski, Bakhos A Tannous, Adrianus J de Langen, Egbert F Smit, Michel M van den Heuvel, Thomas Wurdinger
Blood-based liquid biopsies, including tumor-educated blood platelets (TEPs), have emerged as promising biomarker sources for non-invasive detection of cancer. Here we demonstrate that particle-swarm optimization (PSO)-enhanced algorithms enable efficient selection of RNA biomarker panels from platelet RNA-sequencing libraries (n = 779). This resulted in accurate TEP-based detection of early- and late-stage non-small-cell lung cancer (n = 518 late-stage validation cohort, accuracy, 88%; AUC, 0.94; 95% CI, 0...
August 14, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28806082/the-discovery-of-novel-antimalarial-aminoxadiazoles-as-a-promising-nonendoperoxide-scaffold
#16
Elena Sandoval, María José Lafuente-Monasterio, María J Almela, Pablo Castañeda, María Belén Jiménez Díaz, María S Martínez-Martínez, Jaume Vidal, Íñigo Angulo-Barturen, Paul Bamborough, Jeremy Burrows, Nicholas Cammack, María J Chaparro, José M Coterón, Cristina de Cozar, Benigno Crespo, Beatriz Díaz, Gerard Drewes, Esther Fernández, Santiago Ferrer-Bazaga, María Teresa Fraile, Francisco J Gamo, Sonja Ghidelli-Disse, Rubén Gómez, John Haselden, Sophie Huss, María Luisa León, Jaime de Mercado, Simon J F Macdonald, José Ignacio Martín Hernando, Sara Prats, Margarita Puente, Anne Rodríguez, Juan C de la Rosa, Lourdes Rueda, Carolyn Selenski, Paul Willis, David M Wilson, Michael Witty, Félix Calderón
Since the appearance of resistance to the current front-line antimalarial treatments, ACTs (artemisinin combination therapies), the discovery of novel chemical entities to treat the disease is recognized as a major global health priority. From the GSK antimalarial set, we identified an aminoxadiazole with an antiparasitic profile comparable with artemisinin (1), with no cross-resistance in a resistant strains panel and a potential new mode of action. A medicinal chemistry program allowed delivery of compounds such as 19 with high solubility in aqueous media, an acceptable toxicological profile, and oral efficacy...
August 24, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28800094/socioeconomic-inequalities-in-visits-to-the-dentist-to-receive-professionally-applied-topical-fluoride-in-a-developing-country
#17
Miriam Del Socorro Herrera, Carlo Eduardo Medina-Solís, América Patricia Pontigo-Loyola, Rubén de la Rosa-Santillana, Leticia Ávila-Burgos, Rogelio José Scougall-Vilchis, Sonia Márquez-Rodríguez, Mirna Minaya-Sánchez, Alejandro José Casanova-Rosado
OBJECTIVE: To determine the frequency and associated factors of visits to the dentist in the last year by Nicaraguan schoolchildren to receive professionally applied topical fluoride (PATF). MATERIAL AND METHODS: A cross-sectional study was designed in children from public schools in the city of León, Nicaragua, were included. A series of socioeconomic, sociodemographic, and behavioural variables were collected through a questionnaire. The dependent variable was the visit to the dentist to receive professionally applied topical fluoride in the last year, which was dichotomised as (0) Did not receive PATF and (1) Yes received PATF...
August 11, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28799514/potentially-clinically-relevant-pharmacodynamic-interactions-between-antiepileptic-drugs-and-psychotropic-drugs-an-update
#18
Edoardo Spina, Jose de Leon
BACKGROUND: Prior articles paid little attention to pharmacodynamic drug interactions (DIs) between antiepileptic drugs (AEDs) and the most important psychotropic medications (antidepressants, antipsychotics, benzodiazepines and lithium) which have potential to be clinically relevant. OBJECTIVE: This article aims to provide an updated review of the potentially clinically relevant pharmacodynamic DIs between AEDs and psychotropic medications. Pharmacodynamic DIs take place directly at the site of action of a drug or indirectly by interfering with another physiological mechanism...
August 9, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28777033/pulmonary-embolism-during-stuporous-episodes-of-catatonia-was-found-to-be-the-most-frequent-cause-of-preventable-death-according-to-a-state-mortality-review-6-deaths-in-15-years
#19
Rocio Puentes, Allen Brenzel, Jose de Leon
Case reports have indicated that pulmonary embolism (PE) can be associated with deaths during episodes of catatonia. A 15-year death registry in Kentucky state psychiatric hospitals was reviewed for deaths during episodes of catatonia. From 2002 to May of 2016, reports of 96 deaths at these state psychiatric hospitals were found and reviewed by the state mortality committee. The charts of the identified catatonic patients were thoroughly reviewed. All 6 deaths occurred during episodes of what Fink and Taylor would call retarded catatonia and Ungvari would call acute stuporous catatonia...
August 4, 2017: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/28771611/inverse-association-of-resistin-with-physical-activity-in-the-general-population
#20
Itahisa Marcelino-Rodríguez, Delia Almeida Gonzalez, José Juan Alemán-Sánchez, Buenaventura Brito Díaz, María Del Cristo Rodríguez Pérez, Fadoua Gannar, Santiago Domínguez Coello, Francisco J Cuevas Fernández, Antonio Cabrera de León
AIM: Resistin is a cytokine related with inflammation and ischemic heart disease. Physical activity (PA) prevents chronic inflammation and ischemic heart disease. We studied the relationship of serum concentration of resistin with HDL cholesterol, a known biomarker of PA, and with different measures of PA, in a large sample of the general adult population in the Canary Islands. METHODS: Cross-sectional study of 6636 adults recruited randomly. We analyzed the correlation of resistin and HDL cholesterol with PA (as metabolic equivalent level [MET]), and fitted the results with linear and logistic regression models using adjustment for age, alcohol consumption and smoking...
2017: PloS One
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