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https://www.readbyqxmd.com/read/29679849/global-analysis-of-advanced-metastatic-breast-cancer-decade-report-2005-2015
#1
Fatima Cardoso, Danielle Spence, Shirley Mertz, Dian Corneliussen-James, Kimberly Sabelko, Julie Gralow, Maria-João Cardoso, Fedro Peccatori, Diego Paonessa, Ann Benares, Naomi Sakurai, Marc Beishon, Sarah-Jane Barker, Musa Mayer
Approximately 0.5 million people worldwide die from metastatic breast cancer (mBC) every year. This manuscript provides an overview on the status of mBC in several regions of the world, highlighting the gaps in care, resources, and support available for patients with mBC. Primary research was conducted in 2015 and 2016, comprising four global qualitative and quantitative surveys of approximately 15,000 individuals in 34 countries. Secondary research was conducted using literature reviews of peer-reviewed publications, patient survey reports, and media or online articles...
April 18, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29679621/the-global-burden-of-hyperglycemia-in-pregnancy-trends-from-studies-in-the-last-decade
#2
REVIEW
Bhuvan Martin, David A Sacks
Concurrent with the rise in obesity, global rates of diabetes are increasing at alarming rates in both developed and developing nations. As these conditions become more prevalent among women of reproductive age, rates of hyperglycemia in pregnancy (HIP) are also increasing. HIP is associated with many immediate perinatal complications which affect both maternal and fetal/neonatal health, as well as with more long term complications. Long term complications include an increase in chronic non-communicable diseases in both mother and offspring, therefore affecting future generations...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29679595/utilization-of-real-time-pcr-for-the-assessment-of-egg-burden-in-the-organs-of-schistosoma-japonicum-experimentally-infected-mice
#3
Minh-Anh Dang-Trinh, Jose Ma M Angeles, Kharleezelle J Moendeg, Adrian Miki C Macalanda, Luna Higuchi, Chiho Oto, Masashi Kirinoki, Yuichi Chigusa, Shin-Ichiro Kawazu
Schistosoma japonicum, causing zoonotic intestinal schistosomiasis, is found in China, the Philippines and parts of Indonesia. Severe disease manifestations are basically due to the deposition of eggs in some vital organs such as the liver, spleen and brain. Traditionally, histopathological microscopic examination of the egg burden was used to evaluate the intensity of infection in the affected organs. However, this technique is laborious, time-consuming and requires trained personnel. In this study, real time PCR targeting the mitochondrial NADH dehydrogenase I gene was used to compare with microscopic examination of tissue sections in evaluating the egg burdens in different affected organs...
April 18, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29679545/the-impact-of-ocular-tuberculosis-on-vision-after-two-months-of-intensive-therapy
#4
Suzana Batista Vereza de Oliveira, Ângelo Ferreira Passos, David Jamil Hadad, Lorena Zbyszynski, Pedro Sousa de Almeida Júnior, Luiz Guilherme Schmidt Castellani, Reynaldo Dietze, Moisés Palaci
Tuberculosis (TB) is an infectious disease of global importance with major economic and social burden accounting for 25% of all avoidable deaths in developing countries. Extrapulmonary involvement may occur either in association with clinically apparent pulmonary tuberculosis or in isolation. This cross-sectional descriptive study aimed to evaluate the impact of ocular tuberculosis in visual acuity at baseline and after two months of intensive anti-tuberculous therapy. A sample of 133 pulmonary TB patients, seven disseminated TB, and three pleural TB patients was evaluated...
April 18, 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29679485/identification-and-structure-elucidation-of-the-proresolving-mediators-provides-novel-leads-for-resolution-pharmacology
#5
REVIEW
Jesmond Dalli, Charles N Serhan
Inflammatory diseases are a major socioeconomic burden, with the incidence of such conditions on the rise, especially in western societies. For decades, the primary treatment paradigm for many of these conditions was to develop drugs that inhibit or antagonize the production and biological actions of molecules that were thought to be the culprits in propagating disease, these include cytokines and eicosanoids. This approach is effective in controlling disease propagation; however, long-term exposure to these anti-inflammatories is also associated with many side effects, some of which severe, including immune-suppression...
April 21, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29679405/who-you-are-and-where-you-live-can-determine-how-long-you-live-what-nurses-need-to-know-about-cardiovascular-disease-among-low-income-urban-dwelling-minority-communities
#6
EDITORIAL
Diana-Lyn Baptiste
Urban populations across the globe face unique health challenges in relationship to gender, race, geographical location and socioeconomic status. The global burden of cardiovascular disease is growing problem accounting for 17.3 million deaths in 2013 and projected to increase to 23.6 million by 2030 (American Heart Association, 2017; World Health Organization, 2018). Like many other countries, in the United States, cardiovascular disease is endemic, remaining the greatest cause of hospitalization and mortality; attributing to more than 45% of deaths among American adults (American Heart Association, 2017)...
April 21, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29679364/estimates-of-medication-expenditure-for-ischemic-heart-disease-accompanying-chronic-obstructive-pulmonary-disease
#7
Edyta Rysiak, Izabela Prokop, Ilona Zaręba, Robert M Mróz
Ischemic heart disease (IHD) is a frequent accompaniment of chronic obstructive pulmonary disease (COPD). Co-occurrence of these two diseases is associated with many risk factors, difficulties in implementing appropriate therapies, numerous complications, and high spending for treatment. All these elements significantly reduce the quality of life of patients. The aim of this study was to estimate the expenditure for medications involved with IHD pharmacotherapy in the course of COPD. This retrospective study was based on the review of medical files of 57 patients, 27 women and 30 men, diagnosed with IHD, according to the severity classification, in the course of COPD which was staged according to the GOLD criteria...
April 21, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29679298/future-of-treatment-for-nonalcoholic-steatohepatitis-can-the-use-of-safe-evidence-based-clinically-proven-supplements-provide-the-answer-to-the-unmet-need
#8
REVIEW
Yaron Ilan
The epidemic of nonalcoholic fatty liver disease (NAFLD) has created a real and unmet therapeutic need. The long regulatory pathway and the focus on selected subsets of patients with established and advanced disease are some of the current obstacles to providing effective treatment for the majority of NAFLD patients. The complexity of the disease pathogenesis, which involves multiple mechanisms, requires targeting of more than one pathway or a combination-based therapy. Although the drugs being developed may prevent progression to cirrhosis or may decrease negative liver outcomes, their effects on cardiometabolic health and cancer prevention remain unknown...
April 20, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29678805/mobile-health-to-maintain-continuity-of-patient-centered-care-for-chronic-kidney-disease-content-analysis-of-apps
#9
Ying-Li Lee, Yan-Yan Cui, Ming-Hsiang Tu, Yu-Chi Chen, Polun Chang
BACKGROUND: Chronic kidney disease (CKD) is a global health problem with a high economic burden, which is particularly prevalent in Taiwan. Mobile health apps have been widely used to maintain continuity of patient care for various chronic diseases. To slow the progression of CKD, continuity of care is vital for patients' self-management and cooperation with health care professionals. However, the literature provides a limited understanding of the use of mobile health apps to maintain continuity of patient-centered care for CKD...
April 20, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29678657/development-and-evaluation-of-an-optimal-human-single-chain-variable-fragment-derived-bcma-targeted-car-t-cell-vector
#10
Eric L Smith, Mette Staehr, Reed Masakayan, Ishan J Tatake, Terence J Purdon, Xiuyan Wang, Pei Wang, Hong Liu, Yiyang Xu, Sarah C Garrett-Thomson, Steven C Almo, Isabelle Riviere, Cheng Liu, Renier J Brentjens
B cell maturation antigen (BCMA) has recently been identified as an important multiple myeloma (MM)-specific target for chimeric antigen receptor (CAR) T cell therapy. In CAR T cell therapy targeting CD19 for lymphoma, host immune anti-murine CAR responses limited the efficacy of repeat dosing and possibly long-term persistence. This clinically relevant concern can be addressed by generating a CAR incorporating a human single-chain variable fragment (scFv). We screened a human B cell-derived scFv phage display library and identified a panel of BCMA-specific clones from which human CARs were engineered...
March 28, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29678342/spending-on-health-and-hiv-aids-domestic-health-spending-and-development-assistance-in-188-countries-1995-2015
#11
(no author information available yet)
BACKGROUND: Comparable estimates of health spending are crucial for the assessment of health systems and to optimally deploy health resources. The methods used to track health spending continue to evolve, but little is known about the distribution of spending across diseases. We developed improved estimates of health spending by source, including development assistance for health, and, for the first time, estimated HIV/AIDS spending on prevention and treatment and by source of funding, for 188 countries...
April 17, 2018: Lancet
https://www.readbyqxmd.com/read/29678341/trends-in-future-health-financing-and-coverage-future-health-spending-and-universal-health-coverage-in-188-countries-2016-40
#12
(no author information available yet)
BACKGROUND: Achieving universal health coverage (UHC) requires health financing systems that provide prepaid pooled resources for key health services without placing undue financial stress on households. Understanding current and future trajectories of health financing is vital for progress towards UHC. We used historical health financing data for 188 countries from 1995 to 2015 to estimate future scenarios of health spending and pooled health spending through to 2040. METHODS: We extracted historical data on gross domestic product (GDP) and health spending for 188 countries from 1995 to 2015, and projected annual GDP, development assistance for health, and government, out-of-pocket, and prepaid private health spending from 2015 through to 2040 as a reference scenario...
April 17, 2018: Lancet
https://www.readbyqxmd.com/read/29678160/the-increasing-burden-and-complexity-of-multi-morbidity-and-polypharmacy-in-geriatric-hiv-patients-a-cross-sectional-study-of-people-aged-65-74-years-and-more-than-75-years
#13
G Guaraldi, A Malagoli, A Calcagno, C Mussi, B M Celesia, F Carli, S Piconi, G V De Socio, A M Cattelan, G Orofino, A Riva, E Focà, S Nozza, G Di Perri
BACKGROUND: Geriatric Patients Living with HIV/AIDS (GEPPO) is a new prospective observational multicentre cohort consisting of all the HIV-positive geriatric patients being treated at 10 clinics in Italy, and HIV-negative controls attending a single geriatric clinic. The aim of this analysis of the GEPPO cohort was to compare prevalence and risk factors of individual non-communicable diseases (NCD), multi-morbidity (MM) and polypharmacy (PP) amongst HIV positive and HIV negative controls at enrolment into the GEPPO cohort...
April 20, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29676667/evaluating-the-clinical-value-of-the-hypoxia-burden-index-in-patients-with-obstructive-sleep-apnea
#14
Fengwei Chen, Kun Chen, Cheng Zhang, Xue Chen, Junjun Huang, Peng Jia, Jing Ma, Jue Zhang, Jing Fang, Guangfa Wang
PURPOSE: We aimed to develop a novel index, the hypoxia burden index (HBI), that reflects the degree and duration of oxygen desaturation, and to determine whether this index is better than the apnea hypopnea-index (AHI) for evaluating obstructive sleep apnea (OSA) and cardiovascular diseases morbidities. METHODS: We retrospectively analyzed 459 adult subjects who underwent overnight polysomnography (PSG) in this study. The HBI was calculated by dividing the total desaturation area of SpO2 below 90% by the TST measured in seconds...
April 20, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29676646/ambient-air-pollution-and-clinical-implications-for-susceptible-populations
#15
Laura G Hooper, Joel D Kaufman
Air pollution is associated with a diversity of health effects, and evidence for a causal relationship with specific diseases exists. Exposure to air pollution is ubiquitous and typically beyond the control of the individual; the resulting health burden for the population can be high. Disproportionate effects are seen in individuals who have increased susceptibility to air pollution owing to individual- or community-level characteristics. As studies grow increasingly sophisticated, the understanding of who comprises the susceptible population continuously expands...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676630/international-approach-to-environmental-and-lung-health-a-perspective-from-the-fogarty-international-center
#16
Roger I Glass, Joshua P Rosenthal
The global burden of lung disease is substantial, accounting for an estimated 7.5 million deaths per year, approximately 14% of annual deaths worldwide. The prime illnesses include, in descending order, chronic obstructive pulmonary disease, lung cancer, tuberculosis, acute respiratory infections, asthma, and interstitial lung fibrosis. Key risk factors include smoking, both indoor and outdoor air pollution, and occupational exposures. Although the distribution of both the diseases and the risk factors varies greatly by age, geography, and setting, the greatest burden falls on populations living in low- and middle-income countries...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676564/parasites-under-the-spotlight-applications-of-vibrational-spectroscopy-to-malaria-research
#17
David Perez-Guaita, Katarzyna M Marzec, Andrew Hudson, Corey Evans, Tatyana Chernenko, Christian Matthäus, Milos Miljkovic, Max Diem, Philip Heraud, Jack S Richards, Dean Andrew, David A Anderson, Christian Doerig, Jose Garcia-Bustos, Don McNaughton, Bayden R Wood
New technologies to diagnose malaria at high sensitivity and specificity are urgently needed in the developing world where the disease continues to pose a huge burden on society. Infrared and Raman spectroscopy-based diagnostic methods have a number of advantages compared with other diagnostic tests currently on the market. These include high sensitivity and specificity for detecting low levels of parasitemia along with ease of use and portability. Here, we review the application of vibrational spectroscopic techniques for monitoring and detecting malaria infection...
April 20, 2018: Chemical Reviews
https://www.readbyqxmd.com/read/29676344/histopathological-pattern-of-thyroid-diseases-in-zaria-a-10-year-review
#18
Nasiru Raheem, Saad A Ahmed, Modupeola Oa Samaila
Context: Majority of the previous studies on thyroid diseases in Northern Nigeria focussed mainly on neoplastic lesions. The non-neoplastic lesions are more common and constitute more public health burdens. Aim: To determine the histopathological pattern of thyroid diseases in our region and compare our findings with similar studies in Nigeria and elsewhere. Settings and Design: This is a retrospective study carried out at the Department of Pathology, Ahmadu Bello University Teaching Hospital, Zaria, from January 2005 to December 2014 using specified criteria...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29676181/identification-of-glia-phenotype-modulators-based-on-select-glial-function-regulatory-signaling-pathways
#19
Sun-Hwa Lee, Kyoungho Suk
Despite the considerable social and economic burden on the healthcare system worldwide due to neurodegenerative diseases, there are currently few disease-altering treatment options for many of these conditions. Therefore, new approaches for both prevention and intervention for neurodegenerative diseases are urgently required. Microglia-mediated neurotoxicity is one of the pathologic hallmarks common to Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Current therapeutic approaches to target microglia-mediated neurotoxicity are focused on the identification of glia phenotype modulators (GPMs), which can inhibit the 'classical' pro-inflammatory and neurotoxic phenotypes of microglia...
April 20, 2018: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/29675862/hemodialysis-a-model-for-extreme-physiology-in-a-vulnerable-patient-population
#20
REVIEW
Jeroen P Kooman, Krassimir Katzarski, Frank M van der Sande, Karel M Leunissen, Peter Kotanko
Hemodialysis (HD) is a lifesaving treatment for patients with end-stage renal disease, which is very efficient in the correction of abnormalities of the internal environment. However, this efficiency also induces significant hemodynamic, thermal, and respiratory stressors. These have parallels with the extreme physiologic demands which are normally mainly experienced by healthy subjects under adverse environmental conditions, with the difference that they must be endured by a vulnerable patient population. Hemodynamic stress induced by ultrafiltration leads to a decline in circulating blood volume, which may result in intradialytic hypotension (IDH) and changes in tissue perfusion, which may have long-term consequences for the function of vital organs such as the brain and the heart...
April 19, 2018: Seminars in Dialysis
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