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sepsis intraabdominal

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https://www.readbyqxmd.com/read/28442772/discriminative-and-distinct-phenotyping-by-constrained-tensor-factorization
#1
Yejin Kim, Robert El-Kareh, Jimeng Sun, Hwanjo Yu, Xiaoqian Jiang
Adoption of Electronic Health Record (EHR) systems has led to collection of massive healthcare data, which creates oppor- tunities and challenges to study them. Computational phenotyping offers a promising way to convert the sparse and complex data into meaningful concepts that are interpretable to healthcare givers to make use of them. We propose a novel su- pervised nonnegative tensor factorization methodology that derives discriminative and distinct phenotypes. We represented co-occurrence of diagnoses and prescriptions in EHRs as a third-order tensor, and decomposed it using the CP algorithm...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28260769/morbidity-and-mortality-after-pancreatoduodenectomy-a-five-year-experience-in-bangabandhu-sheikh-mujib-medical-university
#2
B C Das, A S Khan, N E Elahi, M S Uddin, B C Debnath, Z R Khan
Mortality and morbidity was assessed after adoption of a systematic care for patient with pancreatoduodenectomy starting from patient selection and preparation, operative technique, and postoperative care. In this prospective study seventy patients who underwent pancreatoduodenectomy for periampullary carcinoma with curative intent between January 2010 and December 2014 were carefully analyzed prospectively. Patients were selected those who had ampullary carcinoma, lower bile duct carcinoma and small size carcinoma head of pancreas without local invasion and distant metastasis, and the patient who did not have any major disabling comorbid diseases...
January 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28203580/unusual-presentation-of-diffuse-large-b-cell-lymphoma-with-splenic-infarcts
#3
Vivek Kumar, Parita Soni, Vishangi Dave, Jonathan Harris
A 67-year-old man presented with a 3-day history of abdominal pain, fever, and significant weight loss over 2 months. Physical examination revealed left upper quadrant tenderness, hepatomegaly, splenomegaly, and bilateral pitting edema but peripheral lymphadenopathy was absent. Laboratory tests showed anemia, thrombocytopenia, elevated prothrombin time (PT), partial thromboplastin time (PTT), and increased lactate dehydrogenase (LDH). PTT was corrected completely in mixing study. Further workup for the cause of coagulopathy revealed decreased levels of all clotting factors except factor VIII and increase fibrinogen levels, which ruled out disseminated intravascular coagulation (DIC)...
January 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28124967/-a-rare-and-mortal-infection-agent-in-patients-with-hematological-malignancies-saprochaete-capitata
#4
Lale Aydın Kaynar, Zübeyde Nur Özkurt, Burcu Ülküden, Özlem Güzel Tunçcan, Gülbin Aygencel, Nalan Akyürek, Ayşe Kalkancı
Saprochaete capitata (formerly known as Geotrichum capitatum and Blastoschizomyces capitatus) is a rare invasive fungal agent that may lead to mortal clinical course in patients with hematological malignancies. This agent can be colonized in skin, lungs and intestines, and it can cause major opportunistic infections. Invasive systemic infections due to S.capitata have been reported in immunosuppressed patients. In this report, two patients with invasive S.capitata infections detected during the course of persistent neutropenic fever in acute leukemia, were presented...
October 2016: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28041542/-deep-infection-from-colorectum-to-femur-with-a-massive-gas-development-in-a-chronic-multimorbid-male
#5
Melek Inal, Leif Broeng
A serious complication to colorectal carcinoma is perforation and abscess. In this case report of a 75-year-old male an unusual case of deep infection in the femur secondary to colorectal perforation is described. Sepsis, leg pain and swelling may be the only symptom of intraabdominal disease without abdominalia.
December 19, 2016: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/27939180/long-term-morbidity-after-staging-laparotomy-for-hodgkin-s-lymphoma
#6
Inna Lobeck, Beth Rymeski, Karen Burns, Rajaram Nagarajan, Judy Correll, Debra Kent, Roshni Dasgupta
BACKGROUND: A large cohort of Hodgkin's lymphoma (HL) survivors exist. With patients transitioning from pediatric to adult care, practitioners should be aware of potential complications. The aim of this study was to describe the long-term complications of patients who had staging laparotomy for the treatment of HL. METHODS: After institutional review board approval, a retrospective review of hospital records at our institution was performed. Data extracted included demographics, treatment course and long-term postoperative complications...
December 2, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27908337/source-identification-and-source-control
#7
REVIEW
Zeke P Oliver, Jack Perkins
Identifying sources of infection and establishing source control is an essential component of the workup and treatment of sepsis. Investigation with history, physical examination, laboratory tests, and imaging can in identifying sources of infection. All organ systems have the potential to develop sources of infection. However, there are inherent difficulties presented by some that require additional diligence, namely, urinalysis, chest radiographs, and intraabdominal infections. Interventions include administration of antibiotics and may require surgical or other specialist intervention...
February 2017: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/27635100/burst-abdomen-in-pregnancy-a-proposed-management-algorithm
#8
Amalachukwu M Okpala, Samuel A Debrah, Mohammed Mouhajer
Management of the burst abdomen is complex due to the co-morbidities associated with it. When coupled with intraabdominal sepsis and pregnancy, it becomes even more difficult due to the ethical issues that have to be considered when managing both mother and child. Due to the paucity of literature on this subject, a management algorithm has been proposed which aims at tackling this delicate issue. However, the major consideration in the management of these cases is that decisions are to be made based on optimization of the condition of the mother...
June 2016: Ghana Medical Journal
https://www.readbyqxmd.com/read/27559700/fty720-induced-lymphopenia-does-not-aggravate-mortality-in-a-murine-model-of-polymicrobial-abdominal-sepsis
#9
Jana Enderes, Julia van der Linde, Jan Müller, Bich-Thu Tran, Wolfram von Bernstorff, Claus-Dieter Heidecke, Tobias Schulze
BACKGROUND: FTY720 is an immunosuppressive molecule licensed for the treatment of chronic relapsing multiple sclerosis (MS). It attenuates the adaptive immune response by sequestering T cells within secondary lymphoid organs via its action as functional antagonist of sphingosine-1-phasphate. To date, it is unknown whether FTY-induced lymphopenia puts MS patients at increased risk for severe forms of postoperative infectious complications such as abdominal sepsis. OBJECTIVES: To determine the effect of FTY720-induced lymphopenia on survival to sepsis secondary to postoperative intraabdominal infections in a murine model of polymicrobial sepsis...
March 2017: Shock
https://www.readbyqxmd.com/read/27464918/pleural-empyema-following-liver-resection-a-rare-but-serious-complication
#10
Claire Goumard, David Fuks, François Cauchy, Jacques Belghiti, Catherine Paugam-Burtz, Yves Castier, Olivier Soubrane
BACKGROUND: Postoperative pleural empyema following liver resection has not been thoroughly described in the literature yet. Hence, we aimed to describe characteristics of patients experiencing this complication. METHODS: Characteristics and outcomes of 21 patients who developed pleural empyema after hepatectomy, defined as a bacteriologically proven pleural infection with clinical and biological inflammatory signs requiring antibiotherapy and thoracic drainage, from 2001 to 2014, were retrospectively analyzed...
December 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27434223/il-18-il-1-il-17a-axis-a-novel-therapeutic-target-for-neonatal-sepsis
#11
Alan S Cross
Healthy and septic human neonates have elevated serum IL-18 levels compared with adults. Using a murine neonatal model of intraabdominal sepsis with systemic (intraperitoneal) IL-18 complementation, Wynn et al. report that IL-18 potentiated mortality in both neonatal sepsis and endotoxemia through the induction of IL-17A, and depended on IL-1 receptor 1 signaling (but not IL-1β). They propose that targeting this IL-18/IL-1/IL-17A axis may improve outcomes for human neonates with sepsis. However, given the important roles of Th17 responses and IL-18 in host defenses, some caution is in order during a potentially microbe-induced septic process in neonates...
October 2016: Cytokine
https://www.readbyqxmd.com/read/27399110/complete-remission-of-thrombotic-microangiopathy-after-treatment-with-eculizumab-in-a-patient-with-non-shiga-toxin-associated-bacterial-enteritis-a-case-report
#12
Taku Omura, Eizo Watanabe, Yasufumi Otsuka, Yoko Yoshida, Hideki Kato, Masaomi Nangaku, Toshiyuki Miyata, Shigeto Oda
UNLABELLED: To describe a case of complete remission of thrombotic microangiopathy after treatment with eculizumab in a patient with non-Shiga toxin-associated bacterial enteritis. CASE REPORT: Medical/surgical intensive care unit (ICU) of a university teaching hospital.A 62-year-old man presented to a local hospital with mucous and bloody stool persisting for 1 month and worsening abdominal pain for 2 weeks. He had thrombocytopenia and renal dysfunction and was admitted with a diagnosis of sepsis due to intraabdominal infection...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27213251/can-round-ligament-of-the-liver-patch-decrease-the-rate-and-the-grade-of-postoperative-pancreatic-fistula
#13
Katarzyna Mech, Łukasz Wysocki, Tomasz Guzel, Maciej Słodkowski
UNLABELLED: The most serious complication after pancreatic surgical procedures is still a postoperative pancreatic fistula. In clinical practice there are various methods to prevent the formation of pancreatic fistula, but none of them is fully efficient. Recently, the role of grafting the round ligament of the liver on the pancreas is emphasized as a promising procedure which reduces the severity and shortens the healing time of postoperative pancreatic fistula. The aim of the study was to assess the impact of grafting a round ligament patch on the pancreatic stump or the area of the pancreatic anastomosis on the severity and healing of pancreatic fistula after surgical treatment of the pancreas (alternatively on prevention of pancreatic fistula formation)...
March 1, 2016: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/26867474/carbapenem-resistant-klebsiella-pneumoniae-colonization-in-pediatric-and-neonatal-intensive-care-units-risk-factors-for-progression-to-infection
#14
Hacer Akturk, Murat Sutcu, Ayper Somer, Derya Aydın, Rukiye Cihan, Aslı Ozdemir, Asuman Coban, Zeynep Ince, Agop Citak, Nuran Salman
BACKGROUND: Little is known about factors associated with carbapenem-resistant Klebsiella pneumoniae infections in pediatric patients, who are initally colonized with carbapenem-resistant Klebsiella pneumoniae. MATERIALS AND METHODS: A retrospective case-control study was conducted involving pediatric and neonatal intensive care units throughout a five-year period (January 2010-December 2014). Clinical and microbiological data were extracted from Hospital Infection Control Committee reports and patients' medical records...
March 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/26862301/secondary-advanced-abdominal-pregnancy-after-suspected-ruptured-cornual-pregnancy-with-good-maternal-outcome-a-case-with-unusual-gangrenous-fetal-toes-and-ultrasound-diagnoses-managed-by-hysterectomy
#15
Ahmed Samy El-Agwany, El-Sayed El-Badawy, Ahmed El-Habashy, Hesham El-Gammal, Mahmoud Abdelnaby
Incidence of abdominal pregnancy is accounting for 1.4% of all ectopic pregnancies. This is a rare case report of a 35-year-old multigravida who was presented to our hospital at 24 weeks of gestation with advanced live intraabdominal pregnancy diagnosed by ultrasound. The patient was followed up till 28 weeks in hospital for medicolegal viability in Egypt. Midline laparotomy was done, a live baby was delivered, and hysterectomy was done for attached placenta. Mother was discharged in good health, and baby was admitted in neonatal intensive care unit with no congenital anomalies and died after three weeks of sepsis...
2016: Clinical Medicine Insights. Women's Health
https://www.readbyqxmd.com/read/26849964/georeferencing-of-deaths-from-sepsis-in-the-city-of-s%C3%A3-o-paulo
#16
Décio Diament, Fernando Colombari, Adriana Serra Cypriano, Luis Fernando Lisboa, Bento Fortunato Cardoso Dos Santos, Miguel Cendoroglo Neto, Ary Serpa Neto, Eliezer Silva
OBJECTIVE: The aim of the present study was to obtain information about deaths due to sepsis in São Paulo from 2004 to 2009 and their relationship with geographical distribution. METHODS: Causes of death, both main and secondary, were defined according to the codes of the International Classification of Disease version 10 (ICD-10) contained in the database. Sepsis, septic shock, multiple organ failure, pneumonia, urinary tract infection, peritonitis and other intraabdominal infections, skin and soft tissue infections (including surgical wound infection) and meningitis were considered as immediate cause of death or as the condition leading to the immediate cause of death related or associated to sepsis...
March 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/26644097/surgical-treatment-of-crohn-s-disease-indications-results-and-predictive-factors-of-recurrence-and-morbidity
#17
Rania Hefaiedh, Mariem Sabbeh, Nizar Miloudi, Rym Ennaifer, Hayfa Romdhane, Najet Belhadj, Lassad Gharbi, Tahar Khalfallah
BACKGROUND: Crohn's disease management represents a major problem in gastroenterology and general surgery because it affects young subjects and has a major impact on their quality of life. The aims of our study were to identify the indications for surgery in Crohn's disease, the results and the complications of surgery in our series, and to identify possible predictive factors of recurrence and postoperative morbidity. METHODS: A retrospective descriptive study including 38 cases of patients with Crohn's disease who underwent surgical treatment in the department of surgery in Mongi Slim Hospital, during the period between January 1992 and December 2011 was performed...
June 2015: La Tunisie Médicale
https://www.readbyqxmd.com/read/26273749/interaction-effects-of-acute-kidney-injury-acute-respiratory-failure-and-sepsis-on-30-day-postoperative-mortality-in-patients-undergoing-high-risk-intraabdominal-general-surgical-procedures
#18
Minjae Kim, Joanne E Brady, Guohua Li
BACKGROUND: Acute kidney injury (AKI), acute respiratory failure, and sepsis are distinct but related pathophysiologic processes. We hypothesized that these 3 processes may interact to synergistically increase the risk of short-term perioperative mortality in patients undergoing high-risk intraabdominal general surgery procedures. METHODS: We performed a retrospective, observational cohort study of data (2005-2011) from the American College of Surgeons-National Surgical Quality Improvement Program, a high-quality surgical outcomes data set...
December 2015: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/26265898/kluyvera-ascorbata-infections-in-children-a-case-series
#19
Eda Karadağ Öncel, Yasemin Özsürekci, Yakut Akyön, Deniz Gür, Ali Bülent Cengiz, Ateş Kara
Kluyvera is a relatively newly described member of the Enterobacteriaceae family that rarely causes infections in humans. In the pediatric population, it is described in association with clinically significant infections ranging from urinary tract infections to sepsis with multiorgan failure. Our aim is to determine the clinical significance of K. ascorbata infections in the pediatric population at our institution. We retrospectively analyzed clinical microbiology data as from 2006 and identified four clinically significant isolates in this period...
June 2015: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/25837754/association-between-severity-and-the-determinant-based-classification-atlanta-2012-and-atlanta-1992-in-acute-pancreatitis-a-clinical-retrospective-study
#20
Yuhui Chen, Lu Ke, Zhihui Tong, Weiqin Li, Jieshou Li
Recently, the determinant-based classification (DBC) and the Atlanta 2012 have been proposed to provide a basis for study and treatment of acute pancreatitis (AP). The present study aimed to evaluate the association between severity and the DBC, the Atlanta 2012 and the Atlanta 1992, in AP. Patients admitted to our center with AP from January 2007 to July 2013 were reviewed retrospectively. Patients were assigned to severity categories for all the 3 classification systems. The primary outcomes include long-term clinical prognosis (mortality and length-of-hospital stay), major complications (intraabdominal hemorrhage, multiple-organ dysfunction, single organ failure [OF], and sepsis) and clinical interventions (surgical drainage, continuous renal replace therapy [CRRT] lasting time, and mechanical ventilation [MV] lasting time)...
April 2015: Medicine (Baltimore)
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