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https://www.readbyqxmd.com/read/28814637/asymmetric-vestibular-stimulation-reveals-persistent-disruption-of-motion-perception-in-unilateral-vestibular-lesions
#1
Roberto Panichi, Mario Faralli, Rosa Bruni, Artemis Kiriakarely, Chiara Occhigrossi, Aldo Ferraresi, Adolfo M Bronstein, Vito Enrico Pettorossi
Self-motion perception was studied in patients with unilateral vestibular lesions (UVL) due to acute vestibular neuritis at 1 week, 4, 8 and 12 months after the acute episode. We assessed vestibularly-mediated self-motion perception by measuring the error in reproducing the position of a remembered visual target at the end of 4 cycles of asymmetric whole-body rotation. The oscillatory stimulus consists of a slow (0.09Hz) and a fast (0.38Hz) half cycle. A large error was present in UVL patients when the slow half cycle was delivered towards the lesion side, but minimal towards the healthy side...
August 16, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28780862/structure-and-dynamics-of-an-intrinsically-disordered-protein-region-that-partially-folds-upon-binding-by-chemical-exchange-nmr
#2
Cyril Charlier, Guillaume Bouvignies, Philippe Pelupessy, Astrid Walrant, Rodrigue Marquant, Mikhail Kozlov, Pablo De Ioannes, Nicolas Bolik-Coulon, Sandrine Sagan, Patricia Cortes, Aneel K Aggarwal, Ludovic Carlier, Fabien Ferrage
Many intrinsically disordered proteins (IDPs) and protein regions (IDRs) engage in transient, yet specific, interactions with a variety of protein partners. Often, if not always, interactions with a protein partner lead to partial folding of the IDR. Characterizing the conformational space of such complexes is challenging: in solution-state NMR, signals of the IDR in the interacting region become broad, weak and often invisible; while X-ray crystallography only provides information on fully ordered regions...
August 7, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28763673/performance-assessment-of-individual-and-ensemble-data-mining-techniques-for-gully-erosion-modeling
#3
Hamid Reza Pourghasemi, Saleh Yousefi, Aiding Kornejady, Artemi Cerdà
Gully erosion is identified as an important sediment source in a range of environments and plays a conclusive role in redistribution of eroded soils on a slope. Hence, addressing spatial occurrence pattern of this phenomenon is very important. Different ensemble models and their single counterparts, mostly data mining methods, have been used for gully erosion susceptibility mapping; however, their calibration and validation procedures need to be thoroughly addressed. The current study presents a series of individual and ensemble data mining methods including artificial neural network (ANN), support vector machine (SVM), maximum entropy (ME), ANN-SVM, ANN-ME, and SVM-ME to map gully erosion susceptibility in Aghemam watershed, Iran...
July 28, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28760680/genetic-analysis-of-a-per-2-producing-shewanella-spp-strain-harboring-a-variety-of-mobile-genetic-elements-and-antibiotic-resistant-determinants
#4
Marisa Almuzara, Sabrina Montaña, Terese Lazzaro, Sylvia Uong, Gisela Parmeciano Di Noto, German Traglia, Romina Bakai, Daniela Centrón, Andrés Iriarte, Cecilia Quiroga, Maria Soledad Ramirez
OBJECTIVE: The goal of this work is to investigate the molecular mechanisms that explain the multidrug resistant phenotype found in a novel clinical Shewanella spp. strain (Shew256) recovered from a diabetic patient. METHODS: The whole-genome shotgun sequencing was obtained with Illumina MiSeq-I and Nextera XT DNA library. De novo assembly was performed with SPADES. RAST was used to predict the open reading frames and the predictions were confirmed using BLAST. Further genomic analysis was carried out using average nucleotide identity (ANI), ACT (Artemis), OrthoMCL, ARG-ANNOT, ISFinder, PHAST, tRNAscan-SE, plasmidSPAdes, PlasmidFinder and MAUVE...
July 28, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28759779/synthetic-lethality-between-murine-dna-repair-factors-xlf-and-dna-pkcs-is-rescued-by-inactivation-of-ku70
#5
Mengtan Xing, Magnar Bjørås, Jeremy A Daniel, Frederick W Alt, Valentyn Oksenych
DNA double-strand breaks (DSBs) are recognized and repaired by the Classical Non-Homologous End-Joining (C-NHEJ) and Homologous Recombination pathways. C-NHEJ includes the core Ku70 and Ku80 (or Ku86) heterodimer that binds DSBs and thus promotes recruitment of accessory downstream NHEJ factors XLF, PAXX, DNA-PKcs, Artemis and other core subunits, XRCC4 and DNA Ligase 4 (Lig4). In the absence of core C-NHEJ factors, DNA repair can be performed by Alternative End-Joining, which likely depends on DNA Ligase 1 and DNA Ligase 3...
July 26, 2017: DNA Repair
https://www.readbyqxmd.com/read/28747915/t-cell-lymphoma-and-leukemia-in-severe-combined-immunodeficiency-pigs-following-bone-marrow-transplantation-a-case-report
#6
Ellis J Powell, Jared Graham, N M Ellinwood, Jesse Hostetter, Michael Yaeger, Chak-Sum Ho, Lynden Gault, Veronica Norlin, Elizabeth N Snella, Jackie Jens, Emily H Waide, Adeline N Boettcher, Maureen Kerrigan, Raymond R R Rowland, Jason W Ross, Jack C M Dekkers, Christopher K Tuggle
After the discovery of naturally occurring severe combined immunodeficiency (SCID) within a selection line of pigs at Iowa State University, we found two causative mutations in the Artemis gene: haplotype 12 (ART12) and haplotype 16 (ART16). Bone marrow transplants (BMTs) were performed to create genetically SCID and phenotypically immunocompetent breeding animals to establish a SCID colony for further characterization and research utilization. Of nine original BMT transfer recipients, only four achieved successful engraftment...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28744977/supraventricular-premature-beats-and-risk-of-new-onset-atrial-fibrillation-in-coronary-artery-disease
#7
Santeri Nortamo, Tuomas V Kenttä, Olavi Ukkola, Heikki V Huikuri, Juha S Perkiömäki
INTRODUCTION: The significance of premature atrial contraction (PAC) count and supraventricular runs (SVR) for the risk of development of new-onset atrial fibrillation (AF) in patients with coronary artery disease (CAD) is not well established. METHODS: The Innovation to Reduce Cardiovascular Complications of Diabetes at the Intersection (ARTEMIS) study cohort consisted of 1946 patients with CAD who underwent clinical and echocardiographic examinations, 24-hour ambulatory ECG monitoring and laboratory tests...
July 26, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28739276/a-process-of-resection-dependent-nonhomologous-end-joining-involving-the-goddess-artemis
#8
REVIEW
Markus Löbrich, Penny Jeggo
DNA double-strand breaks (DSBs) are a hazardous form of damage that can potentially cause cell death or genomic rearrangements. In mammalian G1- and G2-phase cells, DSBs are repaired with two-component kinetics. In both phases, a fast process uses canonical nonhomologous end joining (c-NHEJ) to repair the majority of DSBs. In G2, slow repair occurs by homologous recombination. The slow repair process in G1 also involves c-NHEJ proteins but additionally requires the nuclease Artemis and DNA end resection. Here, we consider the nature of slow DSB repair in G1 and evaluate factors determining whether DSBs are repaired with fast or slow kinetics...
July 21, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28732621/generic-trypan-blue-as-possible-cause-of%C3%A2-a%C3%A2-cluster-of-toxic-anterior-segment-syndrome-cases-after-uneventful-cataract%C3%A2-surgery
#9
Artemis Matsou, Argyrios Tzamalis, Nikolaos Chalvatzis, Asimina Mataftsi, Ioannis Tsinopoulos, Periklis Brazitikos
Five of 16 patients having uneventful cataract surgery over 2 consecutive days presented on the first postoperative day with painless, unexpected blurry vision; marked limbus-to-limbus corneal edema; and severe anterior chamber inflammation with hypopyon and fibrin formation. Review of the records showed the 5 patients had received an intracameral injection of generic trypan blue solution 0.06% to facilitate the capsulorhexis. Patients who had not received the trypan blue injection had an uneventful first-day check and subsequent course...
June 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28729071/transient-transfection-of-intraerythrocytic-babesia-gibsoni-using-elongation-factor-1-alpha-promoter
#10
Mingming Liu, Masahito Asada, Shinuo Cao, Paul Franck Adjou Moumouni, Patrick Vudriko, Artemis Efstratiou, Hassan Hakimi, Tatsunori Masatani, Fujiko Sunaga, Shin-Ichiro Kawazu, Junya Yamagishi, Xuenan Xuan
The development of gene manipulation techniques has been reported in many protozoan parasites over the past few years. However, these techniques have not yet been established for Babesia gibsoni. Here, we report for the first time, the successful transient transfection of B. gibsoni. The plasmid containing the firefly luciferase reporter gene (pBS-ELA) was transfected into B. gibsoni by an AMAXA 4D Nucleofector™ device. Transfection using program FA113 and Lonza buffer SF showed the highest luciferase expression...
July 17, 2017: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/28701909/biogenic-calcite-particles-from-microalgae-coccoliths-as-a-potential-raw-material
#11
Ioanna Jakob, Makrina Artemis Chairopoulou, Marijan Vučak, Clemens Posten, Ulrich Teipel
Synthetic calcite (CaCO3) particles are found in a broad range of applications. The geometry of particles produced from limestone or precipitation are versatile but limited to basic shapes. The microalga Emiliania huxleyi produces micro-structured calcite platelets, called coccoliths. This article presents the results of an application-orientated study, which includes characteristic values also used in the calcite industry for particle evaluation. It is demonstrated that coccoliths are significantly different from all industrial particles produced so far...
June 2017: Engineering in Life Sciences
https://www.readbyqxmd.com/read/28696258/effects-of-dna-end-configuration-on-xrcc4-dna-ligase-iv-and-its-stimulation-of-artemis-activity
#12
Christina A Gerodimos, Howard H Y Chang, Go Watanabe, Michael R Lieber
In humans, nonhomologous DNA end-joining (NHEJ) is the major pathway by which DNA double-strand breaks are repaired. Recognition of each broken DNA end by the DNA repair protein Ku is the first step in NHEJ, followed by the iterative binding of nucleases, DNA polymerases, and the XRCC4:DNA ligase IV (X4:LIV) complex in an order influenced by the configuration of the two DNA ends at the break site. The endonuclease Artemis improves joining efficiency by functioning in a complex with DNA-dependent protein kinase, catalytic subunit (DNA-PKcs) that carries out endonucleolytic cleavage of 5' and 3' overhangs...
July 10, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28695656/anatolian-honey-is-not-only-sweet-but-can-also-protect-from-breast-cancer-elixir-for-women-from-artemis-to-present
#13
Mehmet Fatih Seyhan, Eren Yılmaz, Özlem Timirci-Kahraman, Neslihan Saygılı, Halil İbrahim Kısakesen, Allison Pınar Eronat, Ayşe Begüm Ceviz, Sema Bilgiç Gazioğlu, Hülya Yılmaz-Aydoğan, Oğuz Öztürk
Natural products with bioactive components are widely studied on various cancer cell lines for their possible cytotoxic effects, recently. Among these products, honey stands out as a valuable bee product containing many active phenolic compounds and flavonoids. Numerous types of multifloral honey and honeydew honey are produced in Turkey owing to its abundant vegetation. Therefore, in this study, we investigated the cytotoxic effects of particular tree-originated honeys from chestnut, cedar, pine, and multifloral honey on cell lines representing different types of the most common cancer of women, breast cancer, MCF7, SKBR3, and MDAMB-231, and fibrocystic breast epithelial cell line, MCF10A as a control...
July 10, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28693116/long-term-follow-up-of-a-child-with-klinefelter-syndrome-and-achondroplasia-from-infancy-to-16-years
#14
Jessica D Arditi, Loretta Thomaidis, Helen Frysira, Artemis Doulgeraki, George P Chrousos, Christina Kanaka-Gantenbein
BACKGROUND: Achondroplasia (ACH), an autosomal dominant skeletal dysplasia, occurs in approximately 1:20,000 births. On the other hand, 47,XXY aneuploidy (Klinefelter syndrome [KS]) is the most common sex chromosome disorder, with a prevalence of approximately 1:600 males. To the best of our knowledge, only five cases of patients presenting both ACH and KS have been reported to date in the international literature. However, none of these cases has been longitudinally followed during the entire childhood...
June 23, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28682765/a-pcr-survey-of-vector-borne-pathogens-in-different-dog-populations-from-turkey
#15
Huanping Guo, Ferda Sevinc, Onur Ceylan, Mutlu Sevinc, Ege Ince, Yang Gao, Paul Franck Adjou Moumouni, Mingming Liu, Artemis Efstratiou, Guanbo Wang, Shinuo Cao, Mo Zhou, Charoonluk Jirapattharasate, Aaron Edmond Ringo, Weiqing Zheng, Xuenan Xuan
In the present study, a total of 192 blood samples were collected from pet dogs, kennel dogs and shepherd dogs in Konya district, Turkey, and tested by specific PCR for the presence of vector-borne pathogens. Several pathogens were identified, most of which can cause substantial morbidity in dogs. PCR results revealed that 54 (28.1%) dogs were infected with one or more pathogens. Positive results were obtained for Babesia spp. in 4 dogs (2.1%), Hepatozoon spp. in 8 dogs (4.2%) and Mycoplasma spp. in 46 dogs (24%)...
September 26, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28672740/long-term-follow-up-of-a-child-with-klinefelter-syndrome-and-achondroplasia-from-infancy-to-16-years
#16
Jessica D Arditi, Loretta Thomaidis, Helen Frysira, Artemis Doulgeraki, George P Chrousos, Christina Kanaka-Gantenbein
BACKGROUND: Achondroplasia (ACH), an autosomal dominant skeletal dysplasia, occurs in approximately 1:20,000 births. On the other hand, 47,XXY aneuploidy (Klinefelter syndrome [KS]) is the most common sex chromosome disorder, with a prevalence of approximately 1:600 males. To the best of our knowledge, only five cases of patients presenting both ACH and KS have been reported to date in the international literature. However, none of these cases has been longitudinally followed during the entire childhood...
July 26, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28659922/a-poly-lactic-co-glycolic-acid-nanovaccine-based-on-chimeric-peptides-from-different-leishmania-infantum-proteins-induces-dendritic-cells-maturation-and-promotes-peptide-specific-ifn%C3%AE-producing-cd8-t-cells-essential-for-the-protection-against-experimental-visceral
#17
Evita Athanasiou, Maria Agallou, Spyros Tastsoglou, Olga Kammona, Artemis Hatzigeorgiou, Costas Kiparissides, Evdokia Karagouni
Visceral leishmaniasis, caused by Leishmania (L.) donovani and L. infantum protozoan parasites, can provoke overwhelming and protracted epidemics, with high case-fatality rates. An effective vaccine against the disease must rely on the generation of a strong and long-lasting T cell immunity, mediated by CD4(+) TH1 and CD8(+) T cells. Multi-epitope peptide-based vaccine development is manifesting as the new era of vaccination strategies against Leishmania infection. In this study, we designed chimeric peptides containing HLA-restricted epitopes from three immunogenic L...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28651085/evolution-of-monitoring-for-giardia-and-cryptosporidium-in-water
#18
REVIEW
Artemis Efstratiou, Jerry Ongerth, Panagiotis Karanis
This review describes the evolution of monitoring methodology for Cryptosporidium and Giardia in water since the 1970's. Methods in current use for Giardia and Cryptosporidium in water are highlighted, though attention is given to all available published methods by country and continent. The review is intended to stimulate research leading to future improvements and further developments in monitoring methodology for Giardia, Cryptosporidium and other waterborne protozoan parasites in water.
June 18, 2017: Water Research
https://www.readbyqxmd.com/read/28589463/experimental-and-theoretical-description-of-the-optical-properties-of-myrcia-sylvatica-essential-oil
#19
Andriele da Silva Prado, Luciano Almeida Leal, Patrick Pascoal de Brito, Antonio Luciano de Almeida Fonseca, Stefan Blawid, Artemis Marti Ceschin, Rosa Helena Veras Mourão, Antônio Quaresma da Silva Júnior, Demétrio Antonio da Silva Filho, Luiz Antonio Ribeiro Junior, Wiliam Ferreira da Cunha
We present an extensive study of the optical properties of Myrcia sylvatica essential oil with the goal of investigating the suitability of its material system for uses in organic photovoltaics. The methods of extraction, experimental analysis, and theoretical modeling are described in detail. The precise composition of the oil in our samples is determined via gas chromatography, mass spectrometry, and X-ray scattering techniques. The measurements indicate that, indeed, the material system of Myrcia sylvatica essential oil may be successfully employed for the design of organic photovoltaic devices...
July 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28583301/the-toronto-thromboprophylaxis-patient-safety-initiative-topps-a-cluster-randomised-trial
#20
Artemis Diamantouros, Alex Kiss, Tina Papastavros, David U, Merrick Zwarenstein, William H Geerts
BACKGROUND: Although venous thromboembolism (VTE) is one of the most common and most preventable complications of hospital stay, review of the literature demonstrates large evidence-care gaps for VTE prevention. OBJECTIVES: This study aimed to determine if a multi-component quality improvement (QI) strategy, including the support of hospital leadership, use of order sets, audit and feedback, and active pharmacy involvement, could increase the use of appropriate thromboprophylaxis in patients hospitalized for hip fracture surgery (HFS), major general surgery (MGS) and acute medical illness (MED)...
September 2017: Research in Social & Administrative Pharmacy: RSAP
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