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https://www.readbyqxmd.com/read/29233324/development-and-evaluation-of-a-continuing-pharmacy-education-cpe-program-in-thrombosis-management
#1
Artemis Diamantouros, Romina Marchesano, William H Geerts, Peter Pennefather, Merrick Zwarenstein, Zubin Austin
BACKGROUND AND PURPOSE: A continuing education (CE) course in thrombosis management for pharmacists was developed through the Office of Continuing Professional Development (CPD) at the University of Toronto to address pharmacists' needs for the knowledge and skills to provide care to patients receiving anticoagulants. This article describes the development of the course as well as the evaluation designed to assess its impact on pharmacists' knowledge, attitudes, and changes in practice...
September 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29227966/pot1-inhibits-the-efficiency-but-promotes-the-fidelity-of-nonhomologous-end-joining-at-non-telomeric-dna-regions
#2
Yang Yu, Rong Tan, Qian Ren, Boya Gao, Zhejin Sheng, Juanlian Zhang, Xiaoqing Zheng, Ying Jiang, Li Lan, Zhiyong Mao
Robust DNA double strand break (DSB) repair and stabilized telomeres help maintain genome integrity, preventing the onset of aging or tumorigenesis. POT1 is one of the six factors in the shelterin complex, which protects telomeres from being recognized as DNA damages. TRF1 and TRF2, two other shelterin proteins, have been shown to participate in DNA DSB repair at non-telomeric regions, but whether POT1, which binds to single strand telomeric DNA at chromosomal ends, is involved in DNA DSB repair has not been assessed...
December 8, 2017: Aging
https://www.readbyqxmd.com/read/29223076/the-impact-of-soil-erosion-on-soil-fertility-and-vine-vigor-a-multidisciplinary-approach-based-on-field-laboratory-and-remote-sensing-approaches
#3
Agata Novara, Antonino Pisciotta, Mario Minacapilli, Antonino Maltese, Fulvio Capodici, Artemi Cerdà, Luciano Gristina
Soil erosion processes in vineyards, beyond surface runoff and sediment transport, have a strong effect on soil organic carbon (SOC) loss and redistribution along the slope. Variation in SOC across the landscape can determine differences in soil fertility and vine vigor. The goal of this research was to analyze the interactions among vines vigor, sediment delivery and SOC in a sloping vineyard located in Sicily. Six pedons were studied along the slope by digging 6 pits up to 60cm depth. Soil was sampled every 10cm and SOC, water extractable organic carbon (WEOC) and specific ultraviolet absorbance (SUVA) were analyzed...
December 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29203527/a-novel-chemical-inducer-of-streptococcus-quorum-sensing-acts-by-inhibiting-the-pheromone-degrading-endopeptidase-pepo
#4
Tiara G Pérez Morales, Kiira Ratia, Duo-Sheng Wang, Artemis Gogos, Tom G Driver, Michael J Federle
Bacteria produce chemical signals (pheromones) to coordinate behaviors across a population in a process termed quorum sensing (QS). QS systems comprising peptide pheromones and their corresponding Rgg receptors are widespread among Firmicutes and may be useful targets for manipulating microbial behaviors, like suppressing virulence. The Rgg2/3 QS circuit of the human pathogen Streptococcus pyogenes controls genes affecting resistance to host lysozyme in response to short hydrophobic pheromones (SHPs). Considering that artificial activation of a QS pathway may be as useful in the objective of manipulating bacteria as inhibiting it, we sought to identify small-molecule inducers of the Rgg2/3 QS system...
December 4, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29174364/identification-and-characterization-of-interchangeable-cross-species-functional-promoters-between-babesia-gibsoni-and-babesia-bovis
#5
Mingming Liu, Paul Franck Adjou Moumouni, Shinuo Cao, Masahito Asada, Guanbo Wang, Yang Gao, Huanping Guo, Jixu Li, Patrick Vudriko, Artemis Efstratiou, Aaron Edmond Ringo, Seung-Hun Lee, Hassan Hakimi, Tatsunori Masatani, Fujiko Sunaga, Shin-Ichiro Kawazu, Junya Yamagishi, Lijun Jia, Noboru Inoue, Xuenan Xuan
The development of transgenic techniques has been reported in many protozoan parasites over the past few years. We recently established a successful transient transfection system for Babesia gibsoni based on Bg 5'-ef-1α promoter. This study investigated 6 homologous and 6 heterologous promoters for B. gibsoni and B. bovis and identified novel interchangeable cross-species functional promoters between B. gibsoni and B. bovis. Ten out of twelve promoters had heterologous promoter function. In particular, Bg 5'-ef-1α and Bg 5'-actin heterologous promoters resulted in a significantly higher luciferase activity than Bb 5'-ef-1α homologous promoter in B...
November 21, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29172002/mental-states-in-moving-shapes-distinct%C3%A2-cortical-and-subcortical-contributions-to-theory-of-mind-impairments-in-dementia
#6
Artemis Synn, Annu Mothakunnel, Fiona Kumfor, Yu Chen, Olivier Piguet, John R Hodges, Muireann Irish
Impaired capacity for Theory of Mind (ToM) represents one of the hallmark features of the behavioral variant of frontotemporal dementia (bvFTD) and is suggested to underpin an array of socioemotional disturbances characteristic of this disorder. In contrast, while social processing typically remains intact in Alzheimer's disease (AD), the cognitive loading of socioemotional tasks may adversely impact mentalizing performance in AD. Here, we employed the Frith-Happé animations as a dynamic on-line assessment of mentalizing capacity with reduced incidental task demands in 18 bvFTD, 18 AD, and 25 age-matched Controls...
November 20, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29156006/diana-tarbase-v8-a-decade-long-collection-of-experimentally-supported-mirna-gene-interactions
#7
Dimitra Karagkouni, Maria D Paraskevopoulou, Serafeim Chatzopoulos, Ioannis S Vlachos, Spyros Tastsoglou, Ilias Kanellos, Dimitris Papadimitriou, Ioannis Kavakiotis, Sofia Maniou, Giorgos Skoufos, Thanasis Vergoulis, Theodore Dalamagas, Artemis G Hatzigeorgiou
DIANA-TarBase v8 (http://www.microrna.gr/tarbase) is a reference database devoted to the indexing of experimentally supported microRNA (miRNA) targets. Its eighth version is the first database indexing >1 million entries, corresponding to ∼670 000 unique miRNA-target pairs. The interactions are supported by >33 experimental methodologies, applied to ∼600 cell types/tissues under ∼451 experimental conditions. It integrates information on cell-type specific miRNA-gene regulation, while hundreds of thousands of miRNA-binding locations are reported...
November 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29155280/molecular-analysis-of-tick-borne-protozoan-and-rickettsial-pathogens-in-small-ruminants-from-two-south-african-provinces
#8
Aaron Edmond Ringo, Paul Franck Adjou Moumouni, Moeti Taioe, Charoonluk Jirapattharasate, Mingming Liu, Guanbo Wang, Yang Gao, Huanping Guo, Seung-Hun Lee, Weiqing Zheng, Artemis Efstratiou, Jixu Li, Noboru Inoue, Hiroshi Suzuki, Oriel Thekisoe, Xuenan Xuan
Tick-borne protozoan and rickettsial diseases are a major threat to livestock in tropical and sub-tropical regions of Africa. In this study we investigated the presence and distribution of Theileria spp., Babesia ovis, Anaplasma ovis, Anaplasma phagocytophilum, Ehrlichia ruminantium and SFG Rickettsia in sheep and goats from Free State and KwaZulu-Natal provinces. A total of 91 blood samples were screened in this study, 61 from goats and 30 from sheep. PCR assay was conducted using primers based on Theileria spp...
November 15, 2017: Parasitology International
https://www.readbyqxmd.com/read/29155101/type-i-ifn-related-netosis-in-ataxia-telangiectasia-and-artemis-deficiency
#9
Ersin Gul, Esra Hazar Sayar, Bilgi Gungor, Fehime Kara Eroglu, Naz Surucu, Sevgi Keles, Sukru Nail Guner, Sıddıka Fındık, Esin Alpdündar, Ihsan Cihan Ayanoglu, Basak Kayaoglu, Busra Nur Geçkin, Hatice Asena Sanli, Tamer Kahraman, Cengiz Yakicier, Meltem Muftuoglu, Berna Oguz, Deniz Nazire Cagdas Ayvaz, Ihsan Gursel, Seza Ozen, Ismail Reisli, Mayda Gursel
BACKGROUND: Pathological inflammatory syndromes of unknown etiology are commonly observed in Ataxia telangiectasia (AT) and Artemis deficiency. Similar inflammatory manifestations also exist in STING-associated vasculopathy in infancy (SAVI) patients. OBJECTIVE: To test the hypothesis that the inflammation associated manifestations observed in AT and Artemis deficient patients stem from increased type I IFN signature leading to neutrophil mediated pathological damage...
November 15, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29154567/faces-and-facets-the-variability-of-emotion-recognition-in-psychopathy-reflects-its-affective-and-antisocial-features
#10
Artemis Igoumenou, Catherine J Harmer, Min Yang, Jeremy W Coid, Robert D Rogers
Psychopathy consists of a constellation of affective-interpersonal features including lack of empathy, callousness, manipulativeness and interpersonal charm, impulsiveness and irresponsibility. Despite its theoretical and predictive value in forensic contexts, the relationships between the psychometric dimensions of psychopathy, including its antisocial features, and the construct's neuropsychological characteristics remain uncertain. In this study, 685 personality-disordered prisoners with histories of serious violent or sexual offenses were assessed for psychopathy before completing a computerized and well-validated assessment of the ability to recognize emotional expressions in the face...
November 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/29154514/simultaneous-splenectomy-and-cholecystectomy-with-single-docking-robotic-platform
#11
Monica Ortenzi, Roberto Ghiselli, Maddalena Baldarelli, Artemis Kolynou, Mario Guerrieri
No abstract text is available yet for this article.
November 20, 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/29143565/hiv-1-resistance-rarely-observed-in-subjects-using-darunavir-once-daily-regimens-across-clinical-studies
#12
Erkki Lathouwers, Eric Y Wong, Donghan Luo, Sareh Seyedkazemi, Sandra De Meyer, Kimberley Brown
BACKGROUND: Darunavir 800 mg once daily (QD) is indicated for HIV-1-infected treatment-naïve and treatment-experienced (without darunavir resistance-associated mutations [RAMs]) individuals, and has been evaluated in phase 2/3 studies with durations between 48 and 192 weeks. OBJECTIVE: To summarize the development (or identification) of post-baseline resistance (RAMs and antiretroviral phenotypic susceptibility) among subjects receiving darunavir QD dosing. METHODS: Seven phase 2/3 studies with available genotypes/phenotypes for subjects treated with ritonavir- or cobicistat-boosted darunavir 800 mg QD regimens were assessed: ARTEMIS (NCT00258557; n = 343), GS-US-299-0102 (NCT01565850; n = 153), GS-US-216-0130 (NCT01440569; n = 313), ODIN (NCT00524368; n = 294), INROADS (NCT01199939; n = 54), MONET (NCT00458302; n = 256), and PROTEA (NCT01448707; n = 273)...
November 16, 2017: HIV Clinical Trials
https://www.readbyqxmd.com/read/29133916/brca2-antagonizes-classical-and-alternative-nonhomologous-end-joining-to-prevent-gross-genomic-instability
#13
Jinhua Han, Chunyan Ruan, Michael S Y Huen, Jiadong Wang, Anyong Xie, Chun Fu, Ting Liu, Jun Huang
BRCA2-deficient cells exhibit gross genomic instability, but the underlying mechanisms are not fully understood. Here we report that inactivation of BRCA2 but not RAD51 destabilizes RPA-coated single-stranded DNA (ssDNA) structures at resected DNA double-strand breaks (DSBs) and greatly enhances the frequency of nuclear fragmentation following cell exposure to DNA damage. Importantly, these BRCA2-associated deficits are fueled by the aberrant activation of classical (c)- and alternative (alt)- nonhomologous end-joining (NHEJ), and rely on the well-defined DNA damage signaling pathway involving the pro-c-NHEJ factor 53BP1 and its downstream effector RIF1...
November 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29102673/amblyopia-due-to-intermediate-uveitis-as-the-presenting-symptom-of-crohn-s-disease-in-a-6-year-old-boy
#14
Chrysanthos Symeonidis, Artemis Matsou, Despoina Tzetzi, Maria Dermenoudi, Periklis Brazitikos, Asimina Mataftsi
No abstract text is available yet for this article.
November 1, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29079086/the-age-of-vines-as-a-controlling-factor-of-soil-erosion-processes-in-mediterranean-vineyards
#15
Jesús Rodrigo-Comino, Eric C Brevik, Artemi Cerdà
Vineyards incur the highest soil and water losses among all Mediterranean agricultural fields. The state-of-the-art shows that soil erosion in vineyards has been primarily surveyed with topographical methods, soil erosion plots and rainfall simulations, but these techniques do not typically assess temporal changes in soil erosion. When vines are planted they are about 30cm high×1cm diameter without leaves, the root system varies from 2 to over 40cm depth, and sometimes the lack of care used during transplanting can result in a field with highly erodible bare soils...
October 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29077542/flavor-preference-and-efficacy-of-variable-dose-ontario-rabies-vaccine-bait-onrab-delivery-in-striped-skunks
#16
Amy Gilbert, Shylo Johnson, Nikki Walker, Alex Beath, Kurt VerCauteren
In North America, terrestrial wildlife rabies control is achieved by oral rabies vaccination programs that principally target mesocarnivores. Success at rabies control in striped skunks (Mephitis mephitis) has been more limited and may require additional enhancements to existing bait products or novel bait designs and attractants. We evaluated preference among captive striped skunks for six different flavors of placebo Ontario Rabies Vaccine Bait (ONRAB®) "Ultralite" Baits (Artemis Technologies, Guelph, Ontario, Canada)...
October 27, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29042493/unraveling-the-self-assembly-of-the-pseudomonas-aeruginosa-xcpq-secretin-periplasmic-domain-provides-new-molecular-insights-into-type-ii-secretion-system-secreton-architecture-and-dynamics
#17
Badreddine Douzi, Nhung T T Trinh, Sandra Michel-Souzy, Aline Desmyter, Geneviève Ball, Pascale Barbier, Artemis Kosta, Eric Durand, Katrina T Forest, Christian Cambillau, Alain Roussel, Romé Voulhoux
The type II secretion system (T2SS) releases large folded exoproteins across the envelope of many Gram-negative pathogens. This secretion process therefore requires specific gating, interacting, and dynamics properties mainly operated by a bipartite outer membrane channel called secretin. We have a good understanding of the structure-function relationship of the pore-forming C-terminal domain of secretins. In contrast, the high flexibility of their periplasmic N-terminal domain has been an obstacle in obtaining the detailed structural information required to uncover its molecular function...
October 17, 2017: MBio
https://www.readbyqxmd.com/read/29042294/impaired-cardiac-autonomic-regulation-and-long-term-risk-of-atrial-fibrillation-in-patients-with-coronary-artery-disease
#18
Santeri Nortamo, Olavi Ukkola, Antti Kiviniemi, Mikko Tulppo, Heikki Huikuri, Juha S Perkiömäki
BACKGROUND: The influence of autonomic cardiac regulation on long-term risk of new-onset atrial fibrillation (AF) in coronary artery disease (CAD) is not well established. OBJECTIVE: The purpose of this study was to evaluate the value of heart rate variability, a marker of cardiac autonomic regulation, in predicting new-onset AF in CAD. METHODS: The Innovation to Reduce Cardiovascular Complications of Diabetes at the Intersection study population consisted of 1946 patients with CAD...
October 16, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28992988/study-of-the-influence-of-surfactants-on-the-activity-coefficients-and-mass-transfer-coefficients-of-methanol-in-aqueous-mixtures-by-reversed-flow-gas-chromatography
#19
Efthimios Kotsalos, Boryana Brezovska, Dimitrios Sevastos, Artemis Vagena, Athanasia Koliadima, John Kapolos, George Karaiskakis
This work focuses on the influences of surfactants on the activity coefficients, γ, of methanol in binary mixtures with water, as well as on the mass transfer coefficients, kc, for the evaporation of methanol, which is a ubiquitous component in the troposphere, from mixtures of methanol with water at various surfactant's and methanol's concentrations. The technique used is the Reversed-Flow Gas Chromatography (R.F.G.C.), a version of Inverse Gas Chromatography, which allows determining both parameters by performing only one experiment for the kc parameter and two experiments for the γ parameter...
November 17, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28942872/association-of-sst2-and-hs-crp-levels-with-new-onset-atrial-fibrillation-in-coronary-artery-disease
#20
Santeri Nortamo, Olavi Ukkola, Samuli Lepojärvi, Tuomas Kenttä, Antti Kiviniemi, Juhani Junttila, Heikki Huikuri, Juha Perkiömäki
BACKGROUND: The data on biomarkers as predictors of atrial fibrillation (AF) in patients with coronary artery disease (CAD) are limited. METHODS: A total of 1946 patients with CAD were recruited to the ARTEMIS study. At baseline, the study patients underwent clinical and echocardiographic examinations and had laboratory tests. The patients (n=1710) with the information about the occurrence of new-onset AF during the follow-up were included in the present analysis...
December 1, 2017: International Journal of Cardiology
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