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Boris M Velichkovsky, Olga A Krotkova, Artemy A Kotov, Vyacheslav A Orlov, Vitaly M Verkhlyutov, Vadim L Ushakov, Maxim G Sharaev
By taking into account Bruce Bridgeman's interest in an evolutionary framing of human cognition, we examine effective (cause-and-effect) connectivity among cortical structures related to different parts of the triune phylogenetic stratification: archicortex, paleocortex and neocortex. Using resting-state functional magnetic resonance imaging data from 25 healthy subjects and spectral Dynamic Causal Modeling, we report interactions among 10 symmetrical left and right brain areas. Our results testify to general rightward and top-down biases in excitatory interactions of these structures during resting state, when self-related contemplation prevails over more objectified conceptual thinking...
June 11, 2018: Consciousness and Cognition
Alireza Arab Ameri, Hamid Reza Pourghasemi, Artemi Cerda
Soil erosion, every year imposes extensive damages to human beings by means of reducing soil productivity and filling reservoirs from sedimentation in Ghaemshahr Basin in Mazandaran Province, (Iran); therefore, identifying prone areas to soil erosion for preventive measures is essential in this basin. In this research, erodibility prioritization of sub-watersheds of Ghaemshahr Basin has done using morphometric parameters analysis and different multi-criteria decision making (MCDM) models such as simple additive weighing (SAW), VlseKriterijumska optimizacija I Kompromisno Resenje (VIKOR), technique for order preference by similarity to ideal solution (TOPSIS), and compound factor (CF)...
February 1, 2018: Science of the Total Environment
Theresa M Catania, Caroline A Branigan, Natalia Stawniak, Jennifer Hodson, David Harvey, Tony R Larson, Tomasz Czechowski, Ian A Graham
Artemisia annua is established as an efficient crop for the production of the anti-malarial compound artemisinin, a sesquiterpene lactone synthesized and stored in Glandular Secretory Trichomes (GSTs) located on the leaves and inflorescences. Amorpha-4,11-diene synthase (AMS) catalyzes the conversion of farnesyl pyrophosphate (FPP) to amorpha-4,11-diene and diphosphate, which is the first committed step in the synthesis of artemisinin. FPP is the precursor for sesquiterpene and sterol biosynthesis in the plant...
2018: Frontiers in Plant Science
Børre Fevang, Unn Merete Fagerli, Hanne Sorte, Harald Aarset, Håkon Hov, Marit Langmyr, Thomas Morten Keil, Ellen Bjørge, Pål Aukrust, Asbjørg Stray-Pedersen, Tobias Gedde-Dahl
The nuclease Artemis is essential for the development of T-cell and B-cell receptors and repair of DNA double-strand breaks, and a loss of expression or function will lead to a radiosensitive severe combined immunodeficiency with no functional T-cells or B-cells (T-B-SCID). Hypomorphic mutations in the Artemis gene can lead to a functional, but reduced, T-cell and B-cell repertoire with a more indolent clinical course called "leaky" SCID. Here, we present the case of a young man who had increasingly aggressive lymphoproliferative skin lesions from 2 years of age which developed into multiple EBV+ B-cell lymphomas, where a hypomorphic mutation in the Artemis gene was found in a diagnostic race against time using whole exome sequencing...
2018: Case Reports in Immunology
Alice Costantini, Panagiotis Ν Krallis, Anders Kämpe, Emmanouil M Karavitakis, Fulya Taylan, Outi Mäkitie, Artemis Doulgeraki
Mutations in the gene encoding plastin-3, PLS3, have recently been associated to severe primary osteoporosis. The molecular function of plastin-3 is not fully understood. Since PLS3 is located on the X chromosome, males are usually more severely affected than females. PLS3 mutations have thus far been reported in approximately 20 young patients with low bone mineral density (BMD). We describe an 8-year-old Greek boy with severe primary osteoporosis with multiple vertebral compression fractures and one low-energy long bone fracture...
June 8, 2018: Journal of Human Genetics
Artemy D Beniaminov, Grigory A Puzanov, George S Krasnov, Dmitry N Kaluzhny, Tatiana P Kazubskaya, Eleonora A Braga, Anna V Kudryavtseva, Nataliya V Melnikova, Alexey A Dmitriev
Hypermethylation of promoter CpG islands is generally recognized epigenetic mechanism responsible for gene silencing in cancer. However, molecular details on how this epigenetic mark triggers the process of gene downregulation are still elusive. Here, we used deep bisulfite sequencing and qPCR analysis to investigate the pattern of CpG methylation of ALDH1L1 promoter region and its association with the gene expression level in 16 paired breast cancer (BC) samples of different clinical stages. Expression of ALDH1L1 gene was suppressed in all examined BC samples up to 200-fold, and average hypermethylation level of the promoter region correlated positively with ALDH1L1 downregulation...
2018: Frontiers in Genetics
S A Kiehas, A Runov, V Angelopolos, H Hietala, D Korovinksiy
As a direct result of magnetic reconnection, plasma sheet fast flows act as primary transporter of mass, flux, and energy in the Earth's magnetotail. During the last decades, these flows were mainly studied within X GSM >-60 R E , as observations near or beyond lunar orbit were limited. By using 5 years (2011-2015) of ARTEMIS (Acceleration, Reconnection, Turbulence, and Electrodynamics of the Moons Interaction with the Sun) data, we statistically investigate earthward and tailward flows at around 60  R E downtail...
March 2018: Journal of Geophysical Research. Space Physics
Artemis G Korovesi, Maria Ntertilis, Vassili N Kouvelis
The nuclear ribosomal protein S3 (Rps3) is implicated in the assembly of the ribosomal small subunit. Fungi and plants present a gene copy in their mitochondrial (mt) genomes. An analysis of 303 complete fungal mt genomes showed that, when rps3 is found, it is either a free-standing gene or an anchored gene within the omega intron of the rnl gene. Early divergent fungi, Basidiomycota and all yeasts but the CTG group belong to the first case, and Pezizomycotina to the second. Its position, size and genetic code employed are conserved within species of the same Order...
May 12, 2018: Molecular Phylogenetics and Evolution
Marinos C Makris, Michael Kornaropoulos, Apostolos Krikelis, Demetrios Moris, Diamantis I Tsilimigras, Elia Modestou, Artemis Liapi, Vasileios Karatzias, Christos Damaskos, Andreas Zevlas
Patients with postradiation therapy for malignancies and/or extensive colorectal surgery are prone to the development of enteroperineal fistulas. Application of biological meshes may prove beneficial in treating complicated enteroperineal fistulas as they provide a stable ground for closing pelvic defects even in contaminated fields.
May 2018: Clinical Case Reports
Dimitrios Doganis, Athanasia Kafasi, Helen Dana, Nikolaos Spanakis, Margarita Baka, Apostolos Pourtsidis, Triantafyllia Sdogou, Artemis Vintila, Vaia Rafailidou, Panagiota Chantzi, Marina Servitzoglou, Despina Bouhoutsou, Maria Varvoutsi, Helen Kosmidis, Maria Tsolia
The aim of this study was to evaluate the ability of influenza immunization to evoke a protective immune response among children with cancer. We evaluated 75 children with cancer who received influenza vaccination. Hemagglutination Inhibition Antibody titers were determined before and after vaccination. The protective rates after vaccination were 79% for H1N1, 75% for H3N2 and 59% for influenza B virus whereas the seroconversion rates were 54%, 44% and 43% respectively. The differences pre- and post-vaccination were significant regardless the method which was used: seroprotection changes, seroconversion and geometric mean titers analyses...
April 30, 2018: Human Vaccines & Immunotherapeutics
John Papastergiou, Chantal Rene Trieu, Deborah Saltmarche, Artemis Diamantouros
OBJECTIVE: Streptococcus pyogenes is an aerobic, gram-positive bacterium responsible for a wide variety of infections including common pharyngitis. Novel rapid antigen detection tests allow for diagnosis of group A Streptococcus (GAS) at the point of care. The objective of the study is to evaluate the effects and feasibility of community pharmacist-directed GAS testing. SETTING: A retrospective analysis of aggregate billing data was conducted using descriptive statistics to evaluate the acceptance and feasibility of a community pharmacist-directed Streptococcus testing program at Shoppers Drug Mart pharmacies in the Canadian provinces of British Columbia, Alberta, and Nova Scotia...
April 19, 2018: Journal of the American Pharmacists Association: JAPhA
Stavros Spiliopoulos, Riccardo Inchingolo, Pierleone Lucatelli, Roberto Iezzi, Athanasios Diamantopoulos, Alessandro Posa, Bryan Barry, Carmelo Ricci, Marco Cini, Chrysostomos Konstantos, Konstantinos Palialexis, Lazaros Reppas, Artemis Trikola, Michele Nardella, Andreas Adam, Elias Brountzos
PURPOSE: To investigate the outcomes of transcatheter arterial embolization (TAE) for the treatment of peptic ulcer bleeding (PUB). MATERIALS AND METHODS: This is a retrospective, multicenter study, which investigated all patients who underwent TAE for the treatment of severe upper gastrointestinal hemorrhage from peptic ulcers in five European centers, between January 1, 2012 and May 1, 2017. All patients had undergone failed endoscopic hemostasis. Forty-four patients (male; mean age 74...
April 18, 2018: Cardiovascular and Interventional Radiology
Christina Daskalopoulou, Brendon Stubbs, Carolina Kralj, Artemis Koukounari, Martin Prince, A Matthew Prina
OBJECTIVES: The number of older people is growing across the world; however, quantitative synthesis of studies examining the impact of lifestyle factors on the ageing process is rare. We conducted a systematic review and meta-analysis of longitudinal studies to synthesise the associations of smoking and alcohol consumption with healthy ageing (HA). METHODS: Major electronic databases were searched from inception to March 2017 (prospectively registered systematic reviews registration number CRD42016038130)...
April 17, 2018: BMJ Open
Lukas Landler, Simon Nimpf, Tobias Hochstoeger, Gregory C Nordmann, Artemis Papadaki-Anastasopoulou, David A Keays
A diverse array of species on the planet employ the Earth's magnetic field as a navigational aid. As the majority of these animals are migratory, their utility to interrogate the molecular and cellular basis of the magnetic sense is limited. Vidal-Gadea and colleagues recently argued that the worm Caenorhabditis elegans possesses a magnetic sense that guides their vertical movement in soil. In making this claim, they relied on three different behavioral assays that involved magnetic stimuli. Here, we set out to replicate their results employing blinded protocols and double wrapped coils that control for heat generation...
April 13, 2018: ELife
Taanvi Ramesh, Artemis Igoumenou, Maria Vazquez Montes, Seena Fazel
BACKGROUND AND AIMS: Violent behaviour by forensic psychiatric inpatients is common. We aimed to systematically review the performance of structured risk assessment tools for violence in these settings. METHODS: The nine most commonly used violence risk assessment instruments used in psychiatric hospitals were examined. A systematic search of five databases (CINAHL, Embase, Global Health, PsycINFO and PubMed) was conducted to identify studies examining the predictive accuracy of these tools in forensic psychiatric inpatient settings...
April 4, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
Artemis Matsou, Konstantinos T Tsaousis
Background: Sarcoidosis constitutes one of the leading causes of ocular inflammation. Chronic ocular sarcoidosis can affect any segment of the eye and its adnexa, producing a wide range of clinical manifestations and severity. If left untreated, permanent visual impairment or even blindness may ensue. Treatment approaches vary from topical therapy to systemic agents that induce immunosuppression to different levels according to disease severity. Objective: To review the published literature on the management options for chronic ocular sarcoidosis and provide a comprehensive list of available treatment strategies, including the newer biologics...
2018: Clinical Ophthalmology
Alice Costantini, Symeon Tournis, Anders Kämpe, Noor Ul Ain, Fulya Taylan, Artemis Doulgeraki, Outi Mäkitie
Osteogenesis imperfecta (OI) is a skeletal dysplasia characterized by brittle bones and extraskeletal manifestations. The disease phenotype varies greatly. Most commonly, OI arises from monoallelic mutations in one of the two genes encoding type I collagen, COL1A1 and COL1A2 and is inherited as an autosomal dominant trait. Here, we describe a consanguineous family with autosomal recessive OI caused by a novel homozygous glycine substitution in COL1A2, NM_000089.3: c.604G>A, p.(Gly202Ser), detected by whole-genome sequencing...
March 23, 2018: Calcified Tissue International
Tiara G Pérez Morales, Kiira Ratia, Duo-Sheng Wang, Artemis Gogos, Laura Bloem, Tom G Driver, Michael J Federle
No abstract text is available yet for this article.
March 23, 2018: Journal of Biological Chemistry
Muhammad A Fareed, Artemis Stamboulis
Glass ionomer cement (GIC) represents a major transformation in restorative dentistry. Wear of dental restoratives is a common phenomenon and the determination of the wear resistance of direct-restorative materials is a challenging task. The aim of this paper was to evaluate the wear resistance of novel glass ionomer cement by two wear-test methods and to compare the two wear methods.The wear resistance of a conventional glass ionomer cement (HiFi Advanced Health Care Kent, UK) and cements modified by including various percentages of nanoclays (1, 2 and 4 wt %) was measured by a reciprocating wear test (ball-on-flat) and Oregon Health and Sciences University's (OHSU) wear simulator...
October 19, 2017: Dentistry journal
Hajri Al-Shehri, Artemis Koukounari, Michelle C Stanton, Moses Adriko, Moses Arinaitwe, Aaron Atuhaire, Narcis B Kabatereine, J Russell Stothard
Programmatic surveillance of intestinal schistosomiasis during control can typically use four diagnostic tests, either singularly or in combination, but these have yet to be cross-compared directly. Our study assembled a complete diagnostic dataset, inclusive of infection intensities, from 258 children from five Ugandan primary schools. The schools were purposely selected as typical of the endemic landscape near Lake Albert and reflective of high- and low-transmission settings. Overall prevalence was: 44.1% (95% CI 38...
March 21, 2018: Parasitology
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