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Nicholas W VanKuren, Manyuan Long
Males and females have different fitness optima but share the vast majority of their genomes, causing an inherent genetic conflict between the two sexes that must be resolved to achieve maximal population fitness. We show that two tandem duplicate genes found specifically in Drosophila melanogaster are sexually antagonistic, but rapidly evolved sex-specific functions and expression patterns that mitigate their antagonistic effects. We use copy-specific knockouts and rescue experiments to show that Apollo (Apl) is essential for male fertility but detrimental to female fertility, in addition to its important role in development, while Artemis (Arts) is essential for female fertility but detrimental to male fertility...
February 19, 2018: Nature Ecology & Evolution
Vaios Peritogiannis, Soultana L Papadopoulou, Athina Tatsioni, Artemis Kapsalaki, Vassiliki Siafaka, Katerina Kotsi, Avraam Ploumis
Background: Physical injury has been associated with the development of several psychopathological manifestations. Less is known about the use of psychiatric medication in those patients. Objectives: This study aimed to explore the use of psychiatric medication by patients been admitted in a rehabilitation center in a tertiary care teaching hospital and to inquire for the correlations of such drug administration. Materials and Methods: The sample consisted of 127 patients who had been admitted to a rehabilitation center, being in the postacute phase of their condition during a 2-year period...
January 2018: Journal of Neurosciences in Rural Practice
Hashini Nilushika Galappaththi-Arachchige, Sigve Holmen, Artemis Koukounari, Elisabeth Kleppa, Pavitra Pillay, Motshedisi Sebitloane, Patricia Ndhlovu, Lisette van Lieshout, Birgitte Jyding Vennervald, Svein Gunnar Gundersen, Myra Taylor, Eyrun Floerecke Kjetland
BACKGROUND: Urine microscopy is the standard diagnostic method for urogenital S. haematobium infection. However, this may lead to under-diagnosis of urogenital schistosomiasis, as the disease may present itself with genital symptoms in the absence of ova in the urine. Currently there is no single reliable and affordable diagnostic method to diagnose the full spectrum of urogenital S. haematobium infection. In this study we explore the classic indicators in the diagnosis of urogenital S...
2018: PloS One
Jina Rajkumari, L Paikhomba Singha, Piyush Pandey
This research employs draft genome sequence data of Klebsiella pneumoniae AWD5 to explore genes that contribute to the degradation of polyaromatic hydrocarbon (PAH) and stimulate plant growth, for rhizosphere-mediated bioremediation. Annotation analysis suggests that the strain AWD5 not only possess gene clusters for PAH utilization, but also for utilization of benzoate, fluorobenzoate, phenylacetate (paa), hydroxyphenylacetic acid (hpa), 3-hydroxyphenyl propionate (mhp). A comparative genome analysis revealed that the genome of AWD5 was highly similar with genomes of environmental as well as clinical K...
February 2018: 3 Biotech
Seung-Hun Lee, Ehab Mossaad, Abdalla Mohamed Ibrahim, Ahmed Ali Ismail, Paul Franck Adjou Moumouni, Mingming Liu, Aaron Edmond Ringo, Yang Gao, Huanping Guo, Jixu Li, Artemis Efstratiou, Peter Musinguzi, Tamador E E Angara, Keisuke Suganuma, Noboru Inoue, Xuenan Xuan
Tick-borne pathogens (TBPs) are common in livestock of sub-Saharan Africa. However, information regarding TBPs in sheep and goats in Sudan is limited. In this study, 178 blood samples of sheep and goats in Blue Nile and West Kordofan states were investigated for TBPs using PCR. Overall, 110 (61.8%) samples were found to be infected with at least one of the following pathogens: Anaplasma ovis, Theileria ovis, and Ehrlichia ruminantium. Babesia ovis and T. lestoquardi were not identified. A. ovis was the most prevalent pathogen (n = 107, 60...
February 1, 2018: Ticks and Tick-borne Diseases
Hai Liu, Xuanxuan Wang, Aihua Huang, Huaping Gao, Yikan Sun, Tingting Jiang, Liming Shi, Xianjie Wu, Qinghua Dong, Xiaonan Sun
Artemis is a key protein of NHEJ (non-homologous end-joining), which is the major pathway for the repair of IR-inducedDSBs in mammalian cells. However, it has not been largely investigated about the expression of Artemis in tumor and the influence of silencing Artemis on the tumor's sensitivity to radiation. In this study, we investigated how expression levels of Artemis may affect treatment outcome of radiotherapy and chemotherapy in colorectal cancer cells. Firstly, we found that the expression of Artemis is strong in some human rectal cancer samples, even can be higher than adjacent normal tissues using immunohistochemical staining...
February 9, 2018: Oncology Research
Artemy D Beniaminov, Lyubov G Dezhenkova, Olga K Mamaeva, Anna K Shchyolkina, Anna N Tevyashova, Dmitry N Kaluzhny, Alexander A Shtil
The current model of binding of the antitumor antibiotic olivomycin A (1) to GC-rich DNA regions presumes that coordination of the magnesium divalent cation with drug dimers is necessary for binding of 1 into the minor groove of the DNA duplex. Previously we have synthesized the derivatives of 1 termed 'short acid' (2) and its N,N-dimethylaminoethylamide (3). The latter compound demonstrated an improved tolerance in vivo compared to 1 and good therapeutic potency in animal models. We herein report that compound 3 is able to form stable complexes with DNA in the absence of Mg2+, in striking contrast to 1 whose binding to the DNA absolutely requires Mg2+...
2018: PloS One
Meral Kayıkçıoğlu, Lale Tokgözoğlu, Ferit Onur Mutluer, Dilek Ural, Murat Biteker
OBJECTIVE: Peripartum cardiomyopathy (PPCM) is left ventricular (LV) systolic dysfunction with an ejection fraction of ≤45% occurring in the later stages of pregnancy or soon after delivery. Although various risk factors have been identified, the exact cause of the disease is unknown. Unlike most countries in the European region, Turkey has yet to determine the current PPCM burden. A registry for this purpose does not exist. To close this gap, the A RegisTry of pEripartuM cardIomyopathy in Turkish patientS (ARTEMIS-I and ARTEMIS-II), was planned and endorsed by the Turkish Society of Cardiology...
January 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
Michail Matalliotakis, Artemis Pontikaki, Athina E Patelarou, Stefanos Zervoudis, Aydin Arici
No abstract text is available yet for this article.
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Stavros Nikolaou, Xenia Hadjikypri, Giasemia Ioannou, Artemis Elia, Pantelis Georgiades
The early stages of mouse placentogenesis (placenta formation) involve poorly understood patterning events within polar trophectoderm-derived trophoblast, the progenitor of all placental trophoblast cell types. By early postimplantation [embryonic day 5.5 (E5.5)], this patterning causes early trophoblast to become subdivided into extraembryonic ectoderm (ExE) and ectoplacental cone (EPC). A prerequisite to understanding this patterning requires knowing the location of ExE-EPC border and being able to distinguish the entire ExE from EPC at E5...
January 2, 2018: Biochemical and Biophysical Research Communications
Ethan C Rath, Stephanie Pitman, Kyu Hong Cho, Yongsheng Bai
BACKGROUND: Small noncoding regulatory RNAs (sRNAs) are post-transcriptional regulators, regulating mRNAs, proteins, and DNA in bacteria. One class of sRNAs, trans-acting sRNAs, are the most abundant sRNAs transcribed from the intergenic regions (IGRs) of the bacterial genome. In Streptococcus pyogenes, a common and potentially deadly pathogen, many sRNAs have been identified, but only a few have been studied. The goal of this study is to identify trans-acting sRNAs that can be substrates of RNase III...
December 28, 2017: BMC Bioinformatics
Artemy Kolchinsky, Nakul Dhande, Kengjeun Park, Yong-Yeol Ahn
We investigate the association between musical chords and lyrics by analysing a large dataset of user-contributed guitar tablatures. Motivated by the idea that the emotional content of chords is reflected in the words used in corresponding lyrics, we analyse associations between lyrics and chord categories. We also examine the usage patterns of chords and lyrics in different musical genres, historical eras and geographical regions. Our overall results confirm a previously known association between Major chords and positive valence...
November 2017: Royal Society Open Science
Luciano Almeida Leal, Leonardo Evaristo de Sousa, Patrick Pascoal de Brito, Bernhard Georg Enders Neto, Artemis Marti Ceschin, Wiliam Ferreira da Cunha, Luiz Antonio Ribeiro, Demétrio Antonio da Silva Filho
The optical properties of systems composed of the polymers PolyeraActivInk™ N2200 and P3HT are experimentally and theoretically investigated using UV-Vis spectroscopy and time-dependent density functional theory calculations, respectively. From a theoretical point of view, we carried out an analysis considering several functionals and model oligomers of different sizes to mimic the polymers. As our studies were performed with and without solvents, a first important result regards the fact that, by considering solvent effects, a better agreement between theoretical and experimental results could be achieved...
December 28, 2017: Journal of Molecular Modeling
Nicholas R Pannunzio, Go Watanabe, Michael R Lieber
Nonhomologous DNA end joining (NHEJ) is the predominant DSB repair pathway throughout the cell cycle and accounts for nearly all DSB repair outside of the S and G2 phases.  NHEJ relies on Ku to thread onto DNA termini and thereby improve the affinity of the NHEJ enzymatic components consisting of polymerases (Pol μ and Pol λ), a nuclease (the Artemis·DNA-PKcs complex), and a ligase (XLF·XRCC4·Lig4 complex).  Each of the enzymatic components is distinctive for its versatility in acting on diverse incompatible DNA end configurations coupled with a flexibility in loading order, resulting in many possible junctional outcomes from one DSB...
December 14, 2017: Journal of Biological Chemistry
Wei-Ren Liang, Munetoshi Maruyama, Hou-Feng Li
The staphylinid tribe Lomechusini is known for the diverse associations with ants or termites. A new species of rove beetle belonging to Zyras (Diaulaconia) is found to be associated with the fungus-growing termite, Odontotermes formosanus (Shiraki, 1909), and is showing meticulous predatory behavior. In the present study, this species is described as Zyras (Diaulaconia) artemis Liang, Maruyama & Li, sp. n. Its assignment to the subgenus Diaulaconia is based on the comparison of female spermatheca, male aedeagus, and male secondary characters...
November 1, 2017: Zootaxa
Artemis Diamantouros, Romina Marchesano, William H Geerts, Peter Pennefather, Merrick Zwarenstein, Zubin Austin
BACKGROUND AND PURPOSE: A continuing education (CE) course in thrombosis management for pharmacists was developed through the Office of Continuing Professional Development (CPD) at the University of Toronto to address pharmacists' needs for the knowledge and skills to provide care to patients receiving anticoagulants. This article describes the development of the course as well as the evaluation designed to assess its impact on pharmacists' knowledge, attitudes, and changes in practice...
September 2017: Currents in Pharmacy Teaching & Learning
Yang Yu, Rong Tan, Qian Ren, Boya Gao, Zhejin Sheng, Juanlian Zhang, Xiaoqing Zheng, Ying Jiang, Li Lan, Zhiyong Mao
Robust DNA double strand break (DSB) repair and stabilized telomeres help maintain genome integrity, preventing the onset of aging or tumorigenesis. POT1 is one of the six factors in the shelterin complex, which protects telomeres from being recognized as DNA damages. TRF1 and TRF2, two other shelterin proteins, have been shown to participate in DNA DSB repair at non-telomeric regions, but whether POT1, which binds to single strand telomeric DNA at chromosomal ends, is involved in DNA DSB repair has not been assessed...
December 8, 2017: Aging
Agata Novara, Antonino Pisciotta, Mario Minacapilli, Antonino Maltese, Fulvio Capodici, Artemi Cerdà, Luciano Gristina
Soil erosion processes in vineyards, beyond surface runoff and sediment transport, have a strong effect on soil organic carbon (SOC) loss and redistribution along the slope. Variation in SOC across the landscape can determine differences in soil fertility and vine vigor. The goal of this research was to analyze the interactions among vines vigor, sediment delivery and SOC in a sloping vineyard located in Sicily. Six pedons were studied along the slope by digging 6 pits up to 60cm depth. Soil was sampled every 10cm and SOC, water extractable organic carbon (WEOC) and specific ultraviolet absorbance (SUVA) were analyzed...
December 6, 2017: Science of the Total Environment
Tiara G Pérez Morales, Kiira Ratia, Duo-Sheng Wang, Artemis Gogos, Tom G Driver, Michael J Federle
Bacteria produce chemical signals (pheromones) to coordinate behaviors across a population in a process termed quorum sensing (QS). QS systems comprising peptide pheromones and their corresponding Rgg receptors are widespread among Firmicutes and may be useful targets for manipulating microbial behaviors, like suppressing virulence. The Rgg2/3 QS circuit of the human pathogen Streptococcus pyogenes controls genes affecting resistance to host lysozyme in response to short hydrophobic pheromones (SHPs). Considering that artificial activation of a QS pathway may be as useful in the objective of manipulating bacteria as inhibiting it, we sought to identify small-molecule inducers of the Rgg2/3 QS system...
December 4, 2017: Journal of Biological Chemistry
Mingming Liu, Paul Franck Adjou Moumouni, Shinuo Cao, Masahito Asada, Guanbo Wang, Yang Gao, Huanping Guo, Jixu Li, Patrick Vudriko, Artemis Efstratiou, Aaron Edmond Ringo, Seung-Hun Lee, Hassan Hakimi, Tatsunori Masatani, Fujiko Sunaga, Shin-Ichiro Kawazu, Junya Yamagishi, Lijun Jia, Noboru Inoue, Xuenan Xuan
The development of transgenic techniques has been reported in many protozoan parasites over the past few years. We recently established a successful transient transfection system for Babesia gibsoni based on Bg 5'-ef-1α promoter. This study investigated 6 homologous and 6 heterologous promoters for B. gibsoni and B. bovis and identified novel interchangeable cross-species functional promoters between B. gibsoni and B. bovis. Ten out of twelve promoters had heterologous promoter function. In particular, Bg 5'-ef-1α and Bg 5'-actin heterologous promoters resulted in a significantly higher luciferase activity than Bb 5'-ef-1α homologous promoter in B...
November 21, 2017: Ticks and Tick-borne Diseases
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