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https://www.readbyqxmd.com/read/29166753/interventional-locoregional-treatment-and-metabolic-response-advantages-of-using-pet-ct-in-the-evaluation-of-response-to-treatment
#1
Monica Finessi, Marilena Bellò, Francesca P Giunta, Andrea Veltri, Désirée Deandreis
INTRODUCTION: Interventional oncology locoregional therapies are validated treatment modalities for primary and secondary tumors in liver, lung, kidney and bone. At this time, there is no accordance in the choice of imaging modality to assess treatment response. Morphological imaging and RECIST 1.1 criteria based on size variation are limited by several critical points. On the other hand the role of functional imaging, in particular by [18F]-fluorodeoxyglucose ([18F]-FDG) positron emission tomography (PET), in both staging and response evaluation of locoregional treatments remains unclear because of the heterogeneous nature of available data...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29166678/laparoscopic-inguinal-hernia-repair-in-infants-and-children-state-of-the-art-technique
#2
Ivy Hau-Yee Chan, Paul Kwong-Hang Tam
No abstract text is available yet for this article.
November 22, 2017: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29166051/a-time-correlation-function-approach-to-nuclear-dynamical-effects-in-x-ray-spectroscopy
#3
Sven Karsten, Sergey I Bokarev, Saadullah G Aziz, Sergei D Ivanov, Oliver Kühn
Modern X-ray spectroscopy has proven itself as a robust tool for probing the electronic structure of atoms in complex environments. Despite working on energy scales that are much larger than those corresponding to nuclear motions, taking nuclear dynamics and the associated nuclear correlations into account may be of importance for X-ray spectroscopy. Recently, we have developed an efficient protocol to account for nuclear dynamics in X-ray absorption and resonant inelastic X-ray scattering spectra [Karsten et al...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29165646/development-and-application-of-a-recombination-based-library-versus-library-high-throughput-yeast-two-hybrid-rll-y2h-screening-system
#4
Fang Yang, Yingying Lei, Meiling Zhou, Qili Yao, Yichao Han, Xiang Wu, Wanshun Zhong, Chenghang Zhu, Weize Xu, Ran Tao, Xi Chen, Da Lin, Khaista Rahman, Rohit Tyagi, Zeshan Habib, Shaobo Xiao, Dang Wang, Yang Yu, Huanchun Chen, Zhenfang Fu, Gang Cao
Protein-protein interaction (PPI) network maintains proper function of all organisms. Simple high-throughput technologies are desperately needed to delineate the landscape of PPI networks. While recent state-of-the-art yeast two-hybrid (Y2H) systems improved screening efficiency, either individual colony isolation, library preparation arrays, gene barcoding or massive sequencing are still required. Here, we developed a recombination-based 'library vs library' Y2H system (RLL-Y2H), by which multi-library screening can be accomplished in a single pool without any individual treatment...
November 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29165544/rna-methylation-and-diseases-experimental-results-databases-web-servers-and-computational-models
#5
Xing Chen, Ya-Zhou Sun, Hui Liu, Lin Zhang, Jian-Qiang Li, Jia Meng
Ribonucleic acid (RNA) methylation is a type of posttranscriptional modifications occurring in all kingdoms of life. It is strongly related to important biological process, thus making it linked to a number of human diseases. Owing to the development of high-throughput sequencing technology, plenty of achievement had been obtained in RNA methylation research recently. Meanwhile, various computational models have been developed to analyze and mining increasing RNA methylation data. In this review, we first made a brief introduction about eight types of most popular RNA methylation, the biological functions of RNA methylation, the relationship between RNA methylation and disease and five important RNA methylation-related diseases...
November 18, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29165372/pedestrian-detection-with-semantic-regions-of-interest
#6
Miao He, Haibo Luo, Zheng Chang, Bin Hui
For many pedestrian detectors, background vs. foreground errors heavily influence the detection quality. Our main contribution is to design semantic regions of interest that extract the foreground target roughly to reduce the background vs. foreground errors of detectors. First, we generate a pedestrian heat map from the input image with a full convolutional neural network trained on the Caltech Pedestrian Dataset. Next, semantic regions of interest are extracted from the heat map by morphological image processing...
November 22, 2017: Sensors
https://www.readbyqxmd.com/read/29165074/state-of-the-art-of-dental-adhesive-systems
#7
Jefferson Ricardo Pereira, Saulo Pamato, Marcos Vargas, Newton Fahl
BACKGROUND: The large dependence on a dental substrate type to bond strength has leveraged the research on materials and techniques that perform different clinical behavior, promoting a stable bonding over time. Bonding to tooth structure has different clinical behaviors and is dependent on several factors. OBJECTIVE: The aim of this paper is to reflect on the state of the art of adhesive systems since Buonocore's experiments to current days. METHODS: An electronic search was conducted on PubMed databases and supplemented with a manual study of relevant references...
November 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29164804/biomaterials-and-advanced-technologies-for-hemostatic-management-of-bleeding
#8
REVIEW
DaShawn A Hickman, Christa L Pawlowski, Ujjal D S Sekhon, Joyann Marks, Anirban Sen Gupta
Bleeding complications arising from trauma, surgery, and as congenital, disease-associated, or drug-induced blood disorders can cause significant morbidities and mortalities in civilian and military populations. Therefore, stoppage of bleeding (hemostasis) is of paramount clinical significance in prophylactic, surgical, and emergency scenarios. For externally accessible injuries, a variety of natural and synthetic biomaterials have undergone robust research, leading to hemostatic technologies including glues, bandages, tamponades, tourniquets, dressings, and procoagulant powders...
November 22, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29164610/shared-pathological-pathways-of-alzheimer-s-disease-with-specific-comorbidities-current-perspectives-and-interventions
#9
REVIEW
Christiane M Nday, Despoina Eleftheriadou, Graham Jackson
Alzheimer's disease (AD) belongs to one of the most multifactorial, complex and heterogeneous morbidity-leading disorders. Despite the extensive research in the field, AD pathogenesis is still at some extend obscure. Mechanisms linking AD with certain comorbidities, namely diabetes mellitus, obesity and dyslipidemia, are increasingly gaining importance, mainly due to their potential role in promoting AD development and exacerbation. Their exact cognitive impairment trajectories, however, remain to be fully elucidated...
November 21, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29164488/spontaneous-elimination-of-hepatitis-c-virus-infection
#10
Maciej Janiak, Kamila Caraballo Cortes, Urszula Demkow, Marek Radkowski
Hepatitis C virus (HCV) is the etiological agent of chronic hepatitis C and a major cause of liver cirrhosis and hepatocellular carcinoma. Only a minority of infected individuals can clear the virus spontaneously. The knowledge of the determinants of virus clearance would allow the development of effective methods preventing its further spread and optimizing treatment regimens. Viral factors associated with spontaneous virus clearance in the acute phase of infection, such as HCV genotype, virus heterogeneity, and the impact of viral proteins on the immune system have been characterized...
November 22, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29164340/correlation-filters-for-detection-of-cellular-nuclei-in-histopathology-images
#11
Asif Ahmad, Amina Asif, Nasir Rajpoot, Muhammad Arif, Fayyaz Ul Amir Afsar Minhas
Nuclei detection in histology images is an essential part of computer aided diagnosis of cancers and tumors. It is a challenging task due to diverse and complicated structures of cells. In this work, we present an automated technique for detection of cellular nuclei in hematoxylin and eosin stained histopathology images. Our proposed approach is based on kernelized correlation filters. Correlation filters have been widely used in object detection and tracking applications but their strength has not been explored in the medical imaging domain up till now...
November 21, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/29163515/nanobody-based-delivery-systems-for-diagnosis-and-targeted-tumor-therapy
#12
REVIEW
Yaozhong Hu, Changxiao Liu, Serge Muyldermans
The development of innovative targeted therapeutic approaches are expected to surpass the efficacy of current forms of treatments and cause less damage to healthy cells surrounding the tumor site. Since the first development of targeting agents from hybridoma's, monoclonal antibodies (mAbs) have been employed to inhibit tumor growth and proliferation directly or to deliver effector molecules to tumor cells. However, the full potential of such a delivery strategy is hampered by the size of mAbs, which will obstruct the targeted delivery system to access the tumor tissue...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163332/clinical-use-of-cerebral-microdialysis-in-patients-with-aneurysmal-subarachnoid-hemorrhage-state-of-the-art
#13
REVIEW
Raimund Helbok, Mario Kofler, Alois Josef Schiefecker, Maxime Gaasch, Verena Rass, Bettina Pfausler, Ronny Beer, Erich Schmutzhard
Objective: To review the published literature on the clinical application of cerebral microdialysis (CMD) in aneurysmal subarachnoid hemorrhage (SAH) patients and to summarize the evidence relating cerebral metabolism to pathophysiology, secondary brain injury, and outcome. Methods: Study selection: Two reviewers identified all manuscripts reporting on the clinical use of CMD in aneurysmal SAH patients from MEDLINE. All identified studies were grouped according to their focus on brain metabolic changes during the early and subacute phase after SAH, their association with mechanisms of secondary brain injury and outcome...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29163063/acetylcholine-neuromodulation-in-normal-and-abnormal-learning-and-memory-vigilance-control-in-waking-sleep-autism-amnesia-and-alzheimer-s-disease
#14
Stephen Grossberg
Adaptive Resonance Theory, or ART, is a neural model that explains how normal and abnormal brains may learn to categorize and recognize objects and events in a changing world, and how these learned categories may be remembered for a long time. This article uses ART to propose and unify the explanation of diverse data about normal and abnormal modulation of learning and memory by acetylcholine (ACh). In ART, vigilance control determines whether learned categories will be general and abstract, or specific and concrete...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/29162861/new-insight-on-the-structural-features-of-the-cytotoxic-auristatins-mmae-and-mmaf-revealed-by-combined-nmr-spectroscopy-and-quantum-chemical-modelling
#15
Mikael P Johansson, Hannu Maaheimo, Filip S Ekholm
Antibody-drug conjugates (ADCs) are emerging as a promising class of selective drug delivery systems in the battle against cancer and other diseases. The auristatins monomethyl auristatin E (MMAE) and monomethyl auristatin F (MMAF) appear as the cytotoxic drug in almost half of the state-of-the-art ADCs on the market or in late stage clinical trials. Here, we present the first complete NMR spectroscopic characterisation of these challenging molecules, and investigate their structural properties by a combined NMR and quantum chemical modelling approach...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29162811/evolution-of-tribo-induced-interfacial-nanostructures-governing-superlubricity-in-a-c-h-and-a-c-h-si-films
#16
Xinchun Chen, Chenhui Zhang, Takahisa Kato, Xin-An Yang, Sudong Wu, Rong Wang, Masataka Nosaka, Jianbin Luo
Hydrogenated amorphous carbon (a-C:H) is capable of providing a near-frictionless lubrication state when rubbed in dry sliding contacts. Nevertheless, the mechanisms governing superlubricity in a-C:H are still not well comprehended, mainly due to the lack of spatially resolved structural information of the buried contact surface. Here, we present structural analysis of the carbonaceous sliding interfaces at the atomic scale in two superlubricious solid lubricants, a-C:H and Si-doped a-C:H (a-C:H:Si), by probing the contact area using state-of-the-art scanning electron transmission microscopy and electron energy-loss spectroscopy...
November 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/29162424/injectable-hydrogels-for-localized-chemo-and-radio-therapy-in-brain-tumors
#17
Pilar de la Puente, Nicole Fettig, Micah J Luderer, Abbey Jin, Shruti Shah, Barbara Muz, Vaishali Kapoor, Sreekrishna M Goddu, Noha Nabil Salama, Christina Tsien, Dinesh Thotala, Kooresh Shoghi, Buck Rogers, Abdel Kareem Azab
PURPOSE: Overall survival of patients with newly diagnosed glioblastoma (GBM) remains dismal at 16 months with state-of-the-art treatment that includes surgical resection, radiation and chemotherapy. GBM tumors are highly heterogeneous and mechanisms for overcoming tumor resistance have not yet fully been elucidated. An injectable chitosan hydrogel capable of releasing chemotherapy (Temozolomide, TMZ) while retaining radioactive isotopes agents (Iodine, (131)I) was used as a vehicle for localized radiation and chemotherapy, within the surgical cavity...
November 18, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29162360/sleep-disordered-breathing-in-heart-failure-the-state-of-the-art-after-the-serve-hf-trial
#18
REVIEW
João Carmo, Inês Araújo, Filipa Marques, Cândida Fonseca
Heart failure (HF) is one of the most prevalent conditions worldwide and despite therapeutic advances, its prognosis remains poor. Among the multiple comorbidities in HF, sleep-disordered breathing (SDB) is frequent and worsens the prognosis. Preliminary observational studies suggested that treatment of SDB could modify the prognosis of HF, and the issue has gained importance in recent years. The diagnosis of SDB is expensive, slow and suboptimal, and there is thus a need for screening devices that are easier to use and validated in this population...
November 18, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29162065/from-policy-to-practice-exploring-the-implementation-of-antiretroviral-therapy-access-and-retention-policies-between-2013-and-2016-in-six-sub-saharan-african-countries
#19
Julie Ambia, Jenny Renju, Alison Wringe, Jim Todd, Eveline Geubbels, Jessica Nakiyingi-Miiro, Mark Urassa, Tom Lutalo, Amelia C Crampin, Daniel Kwaro, Catherine Kyobutungi, Natsayi Chimbindi, F Xavier Gomez-Olive, Malebogo Tlhajoane, Brian Njamwea, Basia Zaba, Paul Mee
BACKGROUND: Understanding the implementation of 2013 World Health Organization (WHO) consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection at the facility level provides important lessons for the roll-out of future HIV policies. METHODS: A national policy review was conducted in six sub-Saharan African countries to map the inclusion of the 2013 WHO HIV treatment recommendations. Twenty indicators of policy adoption were selected to measure ART access (n = 12) and retention (n = 8)...
November 21, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29162041/does-anthracycline-based-chemotherapy-in-pregnant-women-with-cancer-offer-safe-cardiac-and-neurodevelopmental-outcomes-for-the-developing-fetus
#20
Marialuisa Framarino-Dei-Malatesta, Paolo Sammartino, Angela Napoli
BACKGROUND: Cancer treatment during pregnancy is a growing problem especially now that women delay childbearing. Systemic treatment of these malignancies during pregnancy centers mainly on the anticancer drugs anthracyclines, widely used in treating hematological and breast cancer during pregnancy and sometimes associated with early and late toxicity for the fetus. Owing to concern about their cardiac and neurodevelopmental toxicity more information is needed on which anthracycline to prefer and whether they can safely guarantee a cardiotoxicity-free outcome in the fetus...
November 21, 2017: BMC Cancer
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