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IB IVUS

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https://www.readbyqxmd.com/read/27641967/effect-of-sitagliptin-on-plaque-changes-in-coronary-artery-following-acute-coronary-syndrome-in-diabetic-patients-the-especial-acs-study
#1
Shoichi Kuramitsu, Katsumi Miyauchi, Hiroyoshi Yokoi, Satoru Suwa, Yuji Nishizaki, Takayuki Yokoyama, Shuko Nojiri, Masashi Iwabuchi, Shinichi Shirai, Kenji Ando, Shinya Okazaki, Hiroshi Tamura, Hirotaka Watada, Hiroyuki Daida
BACKGROUND: Dipeptidyl peptidase-4 (DPP-4) inhibitors have anti-atherosclerotic and cardioprotective effects in vitro. However, the impact of DPP-4 inhibitors on coronary plaque remains unclear. We sought to assess the effect of sitagliptin on coronary plaque volume (PV) and stabilization in diabetic patients with acute coronary syndrome (ACS). METHODS: The ESPECIAL-ACS was a prospective, randomized, open-label, parallel group study at 4 Japanese centers to assess the effect of 6-month treatment with sitagliptin on coronary plaque changes in non-culprit lesion in diabetic patients with ACS using serial intravascular ultrasound (IVUS) and integrated backscatter IVUS (IB-IVUS) analysis...
September 15, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/27581176/impact-of-malondialdehyde-modified-low-density-lipoprotein-on-tissue-characteristics-in-patients-with-stable-coronary-artery-disease%C3%A3-integrated-backscatter-intravascular-ultrasound-study
#2
Hiroki Ikenaga, Satoshi Kurisu, Shingo Kono, Yoji Sumimoto, Noriaki Watanabe, Takashi Shimonaga, Tadanao Higaki, Toshitaka Iwasaki, Naoya Mitsuba, Ken Ishibashi, Yoshihiro Dohi, Yukihiro Fukuda, Yasuki Kihara
BACKGROUND: Malondialdehyde-modified low-density lipoprotein (MDA-LDL) is considered to play an essential role in plaque destabilization. We aimed to investigate the association between the tissue characteristics of culprit plaque assessed by integrated backscatter (IB)-intravascular ultrasound (IVUS) and the serum MDA-LDL levels in patients with stable coronary artery disease. METHODS AND RESULTS: The study group consisted of 179 patients undergoing IB-IVUS during elective percutaneous coronary intervention...
September 23, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27363224/-relationship-between-coronary-plaque-stability-evaluated-by-intravascular-ultrasound-and-laboratory-parameters
#3
Masanori Kawasaki, Masamitsu Iwasa, Hiromitsu Kanamori, Yoshihisa Yamada, Toshiki Tanaka, Hiroaki Ushikoshi, Yasushi Ohno, Atsushi Mikami, Kazuhiko Nishigaki, Shinya Minatoguchi
Tissue characteristics of coronary plaque have been reported to be associated with cardiovascular events. The stabilization of vulnerable tissue components such as the lipid pool rather than regression of the plaque volume is considered to be of major benefit in the reduction of cardiovascular events. Conventional echocardiography, especially intravascular ultrasound imaging (IVUS), is widely used to determine calcification and the three layers of the arterial wall. However, differentiation of the lipid pool from fibrous tissue using the echo intensity is difficult...
March 2016: Rinsho Byori. the Japanese Journal of Clinical Pathology
https://www.readbyqxmd.com/read/26947600/impact-of-serum-uric-acid-levels-on-coronary-plaque-stability-evaluated-using-integrated-backscatter-intravascular-ultrasound-in-patients-with-coronary-artery-disease
#4
Kaoru Ando, Hiroki Takahashi, Tetsu Watanabe, Hyuma Daidoji, Yoichiro Otaki, Satoshi Nishiyama, Takanori Arimoto, Tetsuro Shishido, Takehiko Miyashita, Takuya Miyamoto, Isao Kubota
AIM: Because the prevalence of hyperuricemia is lower in females than in males, the association between hyperuricemia and cardiovascular disease has been frequently reported in females. Increased serum uric acid levels are associated with the presence of cardiovascular risk factors such as hypertension, renal dysfunction, insulin resistance, and metabolic syndrome. However, it is controversial whether hyperuricemia is an independent risk factor for coronary artery disease in both the genders...
August 1, 2016: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/26936449/a-simple-and-rapid-method-for-identification-of-lesions-at-high-risk-for-the-no-reflow-phenomenon-immediately-before-elective-coronary-stent-implantation
#5
Akira Suda, Shigeto Namiuchi, Tomohiro Kawaguchi, Taro Nihei, Toru Takii, Kenya Saji, Tadashi Sugie, Atsushi Kato, Hiroaki Shimokawa
We aimed to design a rapid and reliable method to identify coronary lesions at high risk for the no-reflow phenomenon before elective coronary stent implantation using integrated backscatter intravascular ultrasound (IB-IVUS). The no-reflow phenomenon occurring during elective percutaneous coronary intervention (PCI) worsens patient prognosis, regardless of whether the phenomenon is transient or persistent. We retrospectively studied 353 coronary lesions to identify factors potentially promoting the no-reflow phenomenon, including lesion location and severity...
March 2, 2016: Heart and Vessels
https://www.readbyqxmd.com/read/26777223/additive-value-of-integrated-backscatter-ivus-for-detection-of-vulnerable-plaque-by-optical-frequency-domain-imaging-an-ex%C3%A2-vivo-autopsy-study-of-human-coronary-arteries
#6
COMPARATIVE STUDY
Masataka Nakano, Kazuyuki Yahagi, Hirosada Yamamoto, Masanori Taniwaki, Fumiyuki Otsuka, Elena R Ladich, Michael Joner, Renu Virmani
OBJECTIVES: This study sought to evaluate the diagnostic performance of optical frequency domain imaging (OFDI) for recognition of coronary plaque morphologies and to assess additive values of integrated backscatter intravascular ultrasound (IB-IVUS) in detection of vulnerable plaque. BACKGROUND: Precise diagnosis of coronary lesions susceptible to plaque rupture and thrombosis may serve to stratify the risk of future coronary events and to make decisions for appropriate treatment of choice...
February 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/26381534/relation-of-lipid-content-of-coronary-plaque-to-level-of-serum-uric-acid
#7
COMPARATIVE STUDY
Yuichi Saito, Takashi Nakayama, Kazumasa Sugimoto, Yoshihide Fujimoto, Yoshio Kobayashi
Elevated serum uric acid (SUA) level is known to be a prognostic factor in patients with acute coronary syndrome (ACS). However, the pathogenesis of the relation between SUA level and coronary plaque characteristics has not been fully evaluated. The aim of this study was to investigate the relation between SUA level and plaque composition of nonculprit lesions in patients with ACS. A total of 81 patients with ACS who underwent intravascular ultrasound (IVUS)-guided percutaneous coronary intervention were included...
November 1, 2015: American Journal of Cardiology
https://www.readbyqxmd.com/read/26289834/association-of-estimated-glomerular-filtration-rate-and-proteinuria-with-lipid-rich-plaque-in-coronary-artery-disease
#8
Yusaku Shimbo, Susumu Suzuki, Hideki Ishii, Yohei Shibata, Yosuke Tatami, Shingo Harata, Naohiro Osugi, Tomoyuki Ota, Akihito Tanaka, Kanako Shibata, Toshihiro Mizukoshi, Yoshinari Yasuda, Shoichi Maruyama, Toyoaki Murohara
BACKGROUND: Estimated glomerular filtration rate (eGFR) and proteinuria are both important determinants of the risk of cardiovascular disease and mortality. The aim of the present study was to investigate the independent and combined effects of eGFR and proteinuria on tissue characterization of the coronary plaques of culprit lesions. METHODS AND RESULTS: Conventional intravascular ultrasound and 3-D integrated backscatter intravascular ultrasound (IB-IVUS) were performed in 555 patients undergoing elective percutaneous coronary intervention...
2015: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/26289581/association-between-blood-glucose-variability-and-coronary-plaque-instability-in-patients-with-acute-coronary-syndromes
#9
Kozo Okada, Kiyoshi Hibi, Masaomi Gohbara, Shunsuke Kataoka, Keiko Takano, Eiichi Akiyama, Yasushi Matsuzawa, Kenichiro Saka, Nobuhiko Maejima, Mitsuaki Endo, Noriaki Iwahashi, Kengo Tsukahara, Masami Kosuge, Toshiaki Ebina, Peter J Fitzgerald, Yasuhiro Honda, Satoshi Umemura, Kazuo Kimura
BACKGROUND: Blood glucose variability is receiving considerable attention as a new risk factor for coronary artery disease. This study aimed to investigate the association between blood glucose variability and coronary plaque tissue characteristics. METHODS: In 57 patients with acute coronary syndrome, integrated backscatter intravascular ultrasound (IB-IVUS) and gray-scale IVUS were performed before balloon dilatation or stent implantation in the culprit vessels...
2015: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/26129657/influence-of-plaque-characteristics-on-fractional-flow-reserve-for-coronary-lesions-with-intermediate-to-obstructive-stenosis-insights-from-integrated-backscatter-intravascular-ultrasound-analysis
#10
COMPARATIVE STUDY
Shinichiro Sakurai, Hiroaki Takashima, Katsuhisa Waseda, Masahiko Gosho, Akiyoshi Kurita, Hirohiko Ando, Kazuyuki Maeda, Akihiro Suzuki, Masanobu Fujimoto, Tetsuya Amano
The aim of this study was to determine the correlation between the fractional flow reserve (FFR) values and volumetric intravascular ultrasound (IVUS) parameters derived from classic gray-scale IVUS and integrated backscatter (IB)-IVUS, taking into account known confounding factors. Patients with unstable angina pectoris with the frequent development of vulnerable plaques often showed the discrepancy between the FFR value and the quantitative coronary angiography findings. Our target population was 107 consecutive subjects with 114 isolated lesions who were scheduled for elective coronary angiography...
October 2015: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/25971408/impact-of-indoxyl-sulfate-a-uremic-toxin-on-non-culprit-coronary-plaque-composition-assessed-on-integrated-backscatter-intravascular-ultrasound
#11
Hiromu Yamazaki, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, Atsunori Kitaoka, Kenya Kusunose, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Masataka Sata
BACKGROUND: Uremic toxin has emerged as an important determinant of cardiovascular risk. The aim of this study was to examine the relationship between serum uremic toxin and coronary plaque composition on integrated backscatter intravascular ultrasound (IB-IVUS). METHODS AND RESULTS: IB-IVUS was performed in 47 patients with planned treatment for angina pectoris. Non-culprit intermediate plaque analyzed in this study had to be >5 mm apart from the intervention site...
2015: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/25886998/direct-relationship-of-local-c-reactive-protein-production-and-lipid-pool-characterized-by-integrated-backscatter-intravascular-ultrasound-a-preliminary-observation
#12
COMPARATIVE STUDY
Yuhei Kobayashi, Hiroyuki Okura, Teruyoshi Kume, Yoshinori Miyamoto, Ryotaro Yamada, Yukari Kobayashi, Kenzo Fukuhara, Terumasa Koyama, Yoji Neishi, Kiyoshi Yoshida
BACKGROUND: Local production of C-reactive protein (CRP) in human coronary arterial plaque was reported as a possible marker for local inflammation and vulnerable plaque. Integrated backscatter intravascular ultrasound (IB-IVUS) plaque tissue characterization may detect vulnerable plaque with high local plaque inflammation. Thus, the aim of this study was to clarify the relationship between IB-IVUS-based plaque characteristics and local high-sensitivity C-reactive protein (hs-CRP) production in stable and unstable plaque...
August 2015: Coronary Artery Disease
https://www.readbyqxmd.com/read/25794984/effects-of-sitagliptin-on-coronary-atherosclerosis-evaluated-using-integrated-backscatter-intravascular-ultrasound-in-patients-with-type-2-diabetes-rationale-and-design-of-the-trust-study
#13
Tsuyoshi Nozue, Kazuki Fukui, Yutaka Koyama, Hiroyuki Fujii, Tomoyuki Kunishima, Hiroyuki Hikita, Kiyoshi Hibi, Akiyoshi Miyazawa, Ichiro Michishita
Patients with diabetes mellitus are at high risk for developing coronary artery disease (CAD), even if they are treated with statins. Several studies have shown the beneficial effects of dipeptidyl peptidase-4 (DPP-4) inhibitors on the cardiovascular system in an animal model. However, recent clinical trials using DPP-4 inhibitors have shown that these inhibitors fail to reduce the occurrence of cardiovascular events. Therefore, this study will be performed to evaluate the effects of sitagliptin, a DPP-4 inhibitor, on coronary atherosclerosis in patients with type 2 diabetes...
May 2016: Heart and Vessels
https://www.readbyqxmd.com/read/25740668/thin-cap-fibroatheroma-defined-as-lipid-core-abutting-lumen-lcal-on-integrated-backscatter-intravascular-ultrasound-comparison-with-optical-coherence-tomography-and-correlation-with-peri-procedural-myocardial-infarction
#14
COMPARATIVE STUDY
Yukio Ozaki, Masaya Ohota, Tevfik F Ismail, Masanori Okumura, Masato Ishikawa, Takashi Muramatsu
BACKGROUND: This study evaluated the ability of a newly developed integrated backscatter intravascular ultrasound (IB-IVUS) system (VISIWAVE, Terumo, Tokyo, Japan) to detect optical coherence tomography (OCT)-verified thin cap fibroatheroma (TCFA) and assessed the correlation with peri-procedural myocardial infarction (PMI) after percutaneous coronary intervention (PCI). METHODS AND RESULTS: One hundred culprit lesions in 100 consecutive patients with ischemic heart disease who consented to repeated IVUS and OCT prior to PCI were studied...
2015: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/25724567/coronary-plaque-progression-of-non-culprit-lesions-after-culprit-percutaneous-coronary-intervention-in-patients-with-moderate-to-advanced-chronic-kidney-disease-intravascular-ultrasound-and-integrated-backscatter-intravascular-ultrasound-study
#15
Kuninobu Kashiyama, Shinjo Sonoda, Yoshitaka Muraoka, Yoshiyuki Suzuki, Fumihiko Kamezaki, Yuki Tsuda, Masaru Araki, Masahito Tamura, Masaaki Takeuchi, Haruhiko Abe, Masahiro Okazaki, Yoshihisa Fujino, Yutaka Otsuji
Previous studies have suggested that the deterioration of renal function increases the risk of major adverse clinical events not only in culprit lesions but also in non-culprit lesions (NCLs) after percutaneous coronary intervention (PCI). This study evaluated serial coronary plaque change of NCL in patients with different stages of chronic kidney disease (CKD) using intravascular ultrasound (IVUS) and integrated backscatter IVUS (IB-IVUS). In 113 patients (113 NCLs) underwent both IVUS-guided PCI and follow-up IVUS, volumetric IVUS analyses were performed at proximal reference NCLs in de novo target vessels post PCI and at 8-month follow-up...
June 2015: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/25519160/plasma-microrna-100-is-associated-with-coronary-plaque-vulnerability
#16
Takeshi Soeki, Koji Yamaguchi, Toshiyuki Niki, Etsuko Uematsu, Sachiko Bando, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Junko Hotchi, Takeshi Tobiume, Shusuke Yagi, Daiju Fukuda, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, Masataka Sata
BACKGROUND: Although numerous studies have reported altered plasma levels of various microRNAs (miRNAs) in patients with cardiovascular disease, there are no data on the relationship between plasma miRNAs and vulnerable coronary plaque. In this study, we investigated whether plasma miRNAs might be a sensitive marker of coronary plaque vulnerability. METHODS AND RESULTS: Integrated backscatter intravascular ultrasound (IB-IVUS) was performed in 32 consecutive patients with angina pectoris who underwent percutaneous coronary intervention...
2015: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/25240169/morphological-features-of-non-culprit-plaques-on-optical-coherence-tomography-and-integrated-backscatter-intravascular-ultrasound-in-patients-with-acute-coronary-syndromes
#17
COMPARATIVE STUDY
Nobuhiko Maejima, Kiyoshi Hibi, Kenichiro Saka, Naoki Nakayama, Yasushi Matsuzawa, Mitsuaki Endo, Noriaki Iwahashi, Jun Okuda, Kengo Tsukahara, Yoshio Tahara, Masami Kosuge, Toshiaki Ebina, Satoshi Umemura, Kazuo Kimura
AIMS: We sought to compare the morphological features of non-culprit plaques with >50% diameter stenosis in patients with acute coronary syndromes (ACS) with those of culprit plaques in patients with ACS and stable angina pectoris (SAP) using optical coherence tomography (OCT) and integrated backscatter intravascular ultrasound (IB-IVUS). METHODS AND RESULTS: A total of 150 culprit and non-culprit coronary plaques (non-culprit vessels) in 150 patients with coronary artery disease were interrogated by OCT before percutaneous coronary intervention (PCI)...
February 2015: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/25217036/feasibility-of-tissue-characterization-of-coronary-plaques-using-320-detector-row-computed-tomography-comparison-with-integrated-backscatter-intravascular-ultrasound
#18
COMPARATIVE STUDY
Shigekiyo Takahashi, Masanori Kawasaki, Shusaku Miyata, Keita Suzuki, Makoto Yamaura, Takahisa Ido, Takuma Aoyama, Hisayoshi Fujiwara, Shinya Minatoguchi
Recently, a new generation of multi-detector row computed tomography (CT) with 320-detector rows (DR) has become available in the clinical settings. The purpose of the present study was to determine the cutoff values of Hounsfield unit (HU) for discrimination of plaque components by comparing HU of coronary plaques with integrated backscatter intravascular ultrasound (IB-IVUS) serving as a gold standard. Seventy-seven coronary atherosclerotic lesions in 77 patients with angina were visualized by both 320-DR CT (Aquilion One, Toshiba, Japan) and IB-IVUS at the same site...
January 2016: Heart and Vessels
https://www.readbyqxmd.com/read/25171387/impact-of-cigarette-smoking-on-coronary-plaque-composition
#19
Soichiro Kumagai, Tetsuya Amano, Hiroaki Takashima, Katsuhisa Waseda, Akiyoshi Kurita, Hirohiko Ando, Kazuyuki Maeda, Yoshitaka Ito, Hideki Ishii, Mutsuharu Hayashi, Daiji Yoshikawa, Susumu Suzuki, Akihito Tanaka, Tatsuaki Matsubara, Toyoaki Murohara
OBJECTIVES: Cigarette smoking is associated with atherosclerosis and is an important risk factor for cardiovascular disease. We evaluated the impact of cigarette smoking on coronary plaque composition using integrated backscatter intravascular ultrasound (IB-IVUS). METHODS: A total of 143 consecutive patients undergoing percutaneous coronary intervention were enrolled. A history of illness, as well as smoking habits, was obtained by interview. Participants were asked to report whether they were current smokers, had quit smoking, or had never smoked...
January 2015: Coronary Artery Disease
https://www.readbyqxmd.com/read/24794757/the-role-of-integrated-backscatter-intravascular-ultrasound-in-characterizing-bare-metal-and-drug-eluting-stent-restenotic-neointima-as-compared-to-optical-coherence-tomography
#20
COMPARATIVE STUDY
Kastsumasa Sato, Charis Costopoulos, Hideo Takebayashi, Toru Naganuma, Tadashi Miyazaki, Kenji Goto, Hiroki Yamane, Arata Hagikura, Yuetsu Kikuta, Masahito Taniguchi, Shigeki Hiramatsu, Hiroshi Ito, Antonio Colombo, Seiichi Haruta
BACKGROUND: To evaluate the role of integrated backscatter intravascular ultrasound (IB-IVUS) in assessing the morphology of neointima in bare-metal stent (BMS) and drug-eluting stent (DES) restenosis as compared to the gold-standard, optical coherence tomography (OCT). METHODS: A total of 120 cross-sections were evaluated by IB-IVUS and OCT at five cross-sections from 24 patients (24 lesions): at the minimal lumen area (MLA) and at 1 and 2mm proximal and distal to the MLA site in 24 lesions (9 treated with DES and 15 treated with BMS)...
December 2014: Journal of Cardiology
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