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https://www.readbyqxmd.com/read/29926359/breakthrough-infection-of-geotrichum-capitatum-during-empirical-caspofungin-therapy-after-umbilical-cord-blood-transplantation
#1
Shuki Oya, Tsuyoshi Muta
We experienced a breakthrough fungal infection caused by Geotrichum capitatum during empirical therapy with caspofungin. A 68-year-old male patient with refractory acute lymphoblastic leukemia had received umbilical cord blood transplantation after two courses of induction therapy. Empirical therapy with caspofungin was initiated 5 days before transplantation. Tacrolimus was continuously infused to prevent graft-versus-host disease. A minidose of methotrexate was intravenously administered on days 1 and 3 post-transplantation, which was changed to prednisolone from day 7 due to severe mucositis...
June 20, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29923253/comparison-of-survival-outcome-between-donor-types-or-stem-cell-sources-for-childhood-acute-myeloid-leukemia-after-allogenic-hematopoietic-stem-cell-transplantation-a-multicenter-retrospective-study-of-study-alliance-of-yeungnam-pediatric-hematology-oncology
#2
Ye Jee Shim, Jae Min Lee, Heung Sik Kim, Nani Jung, Young Tak Lim, Eu Jeen Yang, Jeong Ok Hah, Young-Ho Lee, Hee Won Chueh, Jae Young Lim, Eun Sil Park, Jeong A Park, Ji Kyoung Park, Sang Kyu Park
We compared transplant outcomes between donor types and stem cell sources for childhood acute myeloid leukemia (AML). The medical records of children with AML in the Yeungnam region of Korea from January 2000 to June 2017 were reviewed. In all, 76 children with AML (male-to-female ratio = 46:30) received allogenic hematopoietic stem cell transplantation (allo-HSCT). In total, 29 patients received HSCT from either a matched-related donor or a mismatched-related donor, 32 patients received an unrelated donor, and 15 patients received umbilical cord blood...
June 19, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29921387/comparative-study-of-methotrexate-and-human-umbilical-cord-mesenchymal-stem-cell-transplantation-in-the-treatment-of-rheumatoid-arthritis
#3
Y H Wang, Z Q Yang, S F Zhu, Y Gao
In this study, a collagen-induced arthritis (CIA) model was established to simulate rheumatoid arthritis (RA) using two intradermal injections of bovine type II collagen and Freund’s complete adjuvant mixture given at two-week intervals. Subsequently, the transplantation of human umbilical cord mesenchymal stem cells (hUC-MSCs) was used to treat RA and the treatment efficacy, as well as the possible regulatory mechanism underlying hUC-MSC transplantation, was observed. During the study, forty rats were randomly divided into four groups and their blood samples were collected at different time points to measure levels of serum cartilage oligomeric matrix protein (COMP)...
May 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29920802/allergic-contact-reaction-to-antiseptics-in-very-young-children
#4
A S Darrigade, C Léauté-Labrèze, F Boralevi, A Taïeb, B Milpied
BACKGROUND: Contact dermatitis from topical antiseptic use has been reported mostly in adults but rare cases of chlorhexidine contact dermatitis have also been described in young children. OBJECTIVE: To evaluate contact allergic dermatitis to antiseptics in young children. METHODS: The children mostly referred for a misdiagnose (cellulitis) were patch tested with a selection of the European baseline series, an antiseptics series and the personal topical products used...
June 19, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29920249/endothelial-colony-forming-cells-from-human-umbilical-cord-blood-improved-severe-erectile-dysfunction-in-obese-type-ii-diabetic-rats
#5
Abrar Al-Mahmood Siddiquee, P Ganesan Adaikan, Lang Chu Lau, Baharudin Bin Said, Mark Chong, Jerry Chan, Swee Hin Teoh
AIM: To investigate the effect of intracavernous injection of human umbilical cord blood derived endothelial colony forming cells (HUCB ECFCs) on erectile dysfunction (ED) in Zucker Diabetic Fatty (ZDF) rat model. METHODS: Erectile function was assessed by cavernous nerve electrostimulation in ZDF rats aged 20-28 weeks. Following confirmation of severe ED at the age of 28 weeks, 21 ZDF rats were randomly assigned to three experimental groups: 1 million ECFCs, 2 million ECFCs, and phosphate buffered saline (PBS)...
June 16, 2018: Life Sciences
https://www.readbyqxmd.com/read/29916543/differentiation-of-umbilical-cord-mesenchymal-stem-cells-into-hepatocytes-in-comparison-with-bone-marrow-mesenchymal-stem-cells
#6
Ya-Bin Yu, Yan Song, Ya Chen, Feng Zhang, Fu-Zhen Qi
Mesenchymal stem cells (MSCs) are considered to be an ideal source for the cell therapy of end‑stage liver diseases. Umbilical cord (UC)‑MSCs can be obtained via a non‑invasive procedure and can be easily cultured, making them potentially superior candidates for cell transplantation when compared with MSCs from other sources. In the present study, UC‑MSCs were induced to differentiate into hepatocytes and were compared with bone marrow (BM)‑MSCs for their hepatic differentiation potential. UC‑MSCs showed significantly higher proliferation than BM‑MSCs...
June 18, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29916429/hyperbaric-oxygen-with-cord-blood-transplants-filling-the-donor-gap
#7
Vineet Govinda Gupta, Sameer Bakhshi
Aljitawi OS, Paul S, Ganguly A, Lin TL, Ganguly S, Vielhauer G, Capitano ML, Cantilena A, Lipe B, Mahnken JD, Wise A, Berry A, Singh AK, Shune L, Lominska C, Abhyankar S, Allin D, Laughlin M, McGuirk JP, Broxmeyer HE. (Division of Hematologic Malignancies and Cellular Therapy; Hematology and Transplantation Translational Research Laboratory ; Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas; Division of Hematology/Oncology and Bone Marrow Transplantation Program, University of Rochester Medical Center, Rochester, New York; Department of Urology, University of Kansas Medical Center, Kansas City, Kansas; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana; Cardiovascular Research Institute, Department of Biostatistics, Department of Radiation Oncology, Department of Emergency Medicine, University of Kansas Medical Center, Kansas City, Kansas; Cleveland Cord Blood Center, Cleveland, Ohio; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA...
September 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/29915374/maternal-overweight-and-obesity-increase-the-risk-of-fetal-acidosis-during-labor
#8
Stefan Johansson, Anna Sandström, Sven Cnattingius
OBJECTIVE: To investigate whether maternal overweight and obesity increased the risk of fetal acidosis measured in umbilical cord arterial blood after delivery. STUDY DESIGN: Population-based cohort study of 84,785 term (≥37 weeks) infants. Logistic regression was used to estimate risks of fetal acidosis in umbilical cord arterial blood. Fetal acidosis was defined as pH <7.10 or as pH <1st percentile on a normal reference curve. RESULT: Risks of fetal acidosis increased, regardless of definition, with maternal overweight and obesity severity...
June 19, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29915318/low-affinity-nerve-growth-factor-receptor-cd271-heterogeneous-expression-in-adult-and-fetal-mesenchymal-stromal-cells
#9
Mario Barilani, Federica Banfi, Silvia Sironi, Enrico Ragni, Salomé Guillaumin, Francesca Polveraccio, Lorenzo Rosso, Monica Moro, Giuseppe Astori, Michela Pozzobon, Lorenza Lazzari
Human multipotent mesenchymal stromal cells (MSC) are isolated from a plethora of tissue sources for cell therapy purposes. In 2006, the International Society for Cellular Therapy (ISCT) published minimal guidelines to define MSC identity. Nevertheless, many independent studies demonstrated that cells meeting the ISCT criteria possessed heterogeneous phenotypes and functionalities, heavily influenced by culture conditions. In this study, human MSC derived from many adult (bone marrow and adipose tissue) or fetal (cord blood, Wharton's jelly, umbilical cord perivascular compartment and amniotic fluid) tissues were investigated...
June 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29914273/umbilical-cord-blood-derived-natural-killer-cells-combined-with-bevacizumab-for-colorectal-cancer-treatment
#10
Chen Xu, Dongning Liu, Zhixin Chen, Fan Zhuo, Huankui Sun, Jiaping Hu, Taiyuan Li
Colorectal cancer (CRC) is among cancers with highest incidence globally and currently ranks fourth as the leading cause of cancer-related deaths worldwide. It remains an urgent need for novel strategies in the management of patients with advanced CRC. Adoptive transfer of allogeneic natural killer (NK) cells represent an attractive option in the treatment of patients with CRC. In this study, we successfully expanded NK cells from umbilical cord blood (UCB) with membrane-bound IL-21, termed eUCB-NK cells. eUCB-NK cells efficiently lysed CRC cell lines in vitro and secreted significantly higher levels of IFN-γ, TNF-α, GM-CSF and CCL3 compared with IL-2 stimulated NK cells...
June 19, 2018: Human Gene Therapy
https://www.readbyqxmd.com/read/29914060/translational-regenerative-therapies-for-chronic-spinal-cord-injury
#11
REVIEW
Kyriakos Dalamagkas, Magdalini Tsintou, Amelia Seifalian, Alexander M Seifalian
Spinal cord injury is a chronic and debilitating neurological condition that is currently being managed symptomatically with no real therapeutic strategies available. Even though there is no consensus on the best time to start interventions, the chronic phase is definitely the most stable target in order to determine whether a therapy can effectively restore neurological function. The advancements of nanoscience and stem cell technology, combined with the powerful, novel neuroimaging modalities that have arisen can now accelerate the path of promising novel therapeutic strategies from bench to bedside...
June 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29912599/the-impact-of-nuchal-cord-on-umbilical-cord-blood-gas-analysis-and-ischaemia-modified-albumin-levels-in-elective-c-section
#12
Aslı Yarcı Gursoy, Burcin Ozgu, Yasemin Tasci, Tuba Candar, Salim Erkaya, Gamze Sinem Caglar
This study was designed to evaluate umbilical cord ischaemia-modified albumin (IMA) levels and the cord blood gas parameters of foetuses with or without nuchal cords, at the time of elective C-section. The cross-sectional study population consisted of the patients who were admitted to the Tertiary Care Center between February and June 2015. Women with uncomplicated single term gestations between 37 and 40 completed weeks and scheduled for elective C-sections were included in the study. Fifty cases with a nuchal cord and 50 cases without a nuchal cord were recruited...
June 18, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29911045/congenital-hypothyroidism-screening-in-term-neonates-using-umbilical-cord-blood-tsh-values
#13
Ravi Bhatia, Dinesh Rajwaniya
Congenital hypothyroidism remains one of the most common preventable causes of mental retardation among children. Screening for congenital hypothyroidism remains one of the most cost-effective tools to prevent mental retardation in the population. Umbilical cord blood thyroid-stimulating hormone (TSH) levels remain an attractive and a practical step for screening for congenital hypothyroidism. The aims of this study were as follows: (1) to find normative values of cord blood TSH for the study group and (2) to use cord blood TSH levels as a marker for screening of congenital hypothyroidism...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29909688/single-factor-sox2-mediates-direct-neural-reprogramming-of-human-mesenchymal-stem-cells-via-transfection-of-in-vitro-transcribed-mrna
#14
Bo-Eun Kim, Soon Won Choi, Ji-Hee Shin, Jae-Jun Kim, Insung Kang, Byung-Chul Lee, Jin Young Lee, Myoung Geun Kook, Kyung-Sun Kang
Neural stem cells (NSCs) are a prominent cell source for understanding neural pathogenesis and for developing therapeutic applications to treat neurodegenerative disease because of their regenerative capacity and multipotency. Recently, a variety of cellular reprogramming technologies have been developed to facilitate in vitro generation of NSCs, called induced NSCs (iNSCs). However, the genetic safety aspects of established virus-based reprogramming methods have been considered, and non-integrating reprogramming methods have been developed...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29909265/intrapartum-and-perinatal-results-associated-with-different-degrees-of-staining-of-meconium-stained-amniotic-fluid
#15
Vanesa Rodríguez Fernández, Carlos Nicolás López Ramón Y Cajal, Elena Marín Ortiz, Emilio Couceiro Naveira
OBJECTIVE: To determine the intrapartum and perinatal results associated with different degrees of staining of meconium stained amniotic fluid (MSAF). STUDY DESIGN: In a retrospective cohort study of all singleton deliveries over a period of one year (2015) in a tertiary hospital, we compared different degrees of MSAF (yellow, green and thick) to clear amniotic fluids, and analysed in each group maternal, intrapartum and neonatal variables as well as umbilical cord blood gas analysis...
March 20, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29908648/maternal-perceived-stress-during-pregnancy-increases-risk-for-low-neonatal-iron-at-delivery-and-depletion-of-storage-iron-at-one-year
#16
Danielle N Rendina, Sharon E Blohowiak, Christopher L Coe, Pamela J Kling
OBJECTIVE: To investigate the impact of maternal stress during pregnancy on newborn iron and stage 1 iron deficiency at 1 year of age. STUDY DESIGN: In total, 245 mothers and their newborn infants (52% male; 72% white) were recruited at the Meriter Hospital Birthing Center on the basis of known risk factors for iron deficiency. Umbilical cord blood hemoglobin and zinc protoporphyrin/heme (ZnPP/H) were determined to evaluate erythrocyte iron and plasma ferritin was determined to reflect storage iron...
June 14, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29908640/comparative-study-of-regenerative-effects-of-mesenchymal-stem-cells-derived-from-placental-amnion-chorion-and-umbilical-cord-on-dermal-wounds
#17
Juliane Ertl, Melanie Pichlsberger, Alexandru-Cristian Tuca, Paul Wurzer, Jakob Fuchs, Stefan H Geyer, Barbara Maurer-Gesek, Wolfgang J Weninger, Dagmar Pfeiffer, Vladimir Bubalo, Daryousch Parvizi, Lars-Peter Kamolz, Ingrid Lang
OBJECTIVE: Mesenchymal stem/stromal cells derived from human term placentas (PMSCs) are novel therapeutic agents and more topical than ever. Here we evaluated the effects of three types of PMSCs on wound healing in an in vivo mouse model: Amnion-derived MSCs (AMSCs), blood vessel-derived MSCs (BV-MSCs) from the chorionic plate and Wharton's jelly-derived MSCs (WJ-MSCs) from the umbilical cord. METHODS: We topically applied PMSCs onto skin wounds in mice using the dermal substitute Matriderm® as carrier and evaluated wound healing parameters...
May 2018: Placenta
https://www.readbyqxmd.com/read/29908638/gadd45a-knockdown-alleviates-oxidative-stress-through-suppressing-the-p38-mapk-signaling-pathway-in-the-pathogenesis-of-preeclampsia
#18
Fa-Hong Li, Na Han, Yong Wang, Qian Xu
OBJECTIVE: Preeclampsia (PE) is a hypertensive disease associated with vascular oxidative stress (OS). Besides, cell response to OS triggers growth arrest and DNA damage inducible alpha (Gadd45a). Herein, we investigated the effect of Gadd45a on OS in PE. METHODS: Umbilical cord tissues and peripheral blood samples were collected from PE patients and normal pregnant women. Immunohistochemistry was applied to identify Gadd45a level and extent of p38 phosphorylation...
May 2018: Placenta
https://www.readbyqxmd.com/read/29908375/the-change-of-fetal-heart-rate-short-term-variability-during-the-course-of-histological-chorioamnionitis-in-fetal-sheep
#19
Hyo Kyozuka, Syun Yasuda, Tsuyoshi Hiraiwa, Yasuhisa Nomura, Keiya Fujimori
OBJECTIVE: Histological chorioamnionitis (CAM) is related to neonatal mortality and morbidity. However, identifying intrauterine inflammation before delivery is challenging. The aim of this study was to investigate the changes in fetal heart rate (FHR) short-term variability (STV) during the course of histological CAM. STUDY DESIGN: Changes in STV were measured in 7 chronically instrumented fetal sheep at 111-120 days of gestation. Lipopolysaccharide (LPS) was infused into the amniotic cavity for 2 days following the 4th postoperative day to develop histological CAM...
June 11, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29908373/validation-of-diagnostic-tests-for-histologic-chorioamnionitis-systematic-review-and-meta-analysis
#20
Claudia Patricia Cataño Sabogal, Javier Fonseca, Herney Andrés García-Perdomo
INTRODUCTION: The aim of this study was to determine the diagnostic performance of different diagnostic tests for histologic chorioamnionitis in patients at more than 20 weeks of gestation. METHODS: A systematic search was carried out through MEDLINE, EMBASE, LILACS, CENTRAL and unpublished literature. Observational studies included with pregnant women (>20 weeks) with chorioamnionitis. The reference standard was the histopathological study of the placenta, umbilical cord and fetal membranes...
June 9, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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