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umbilical cord

Junko Ikemoto, Satoshi Yoshihara, Tamami Kobayashi, Shunro Kai, Yoshihiro Fujimori
In umbilical cord blood transplantation (UCBT), the number of cluster of differentiation (CD)34+ cells and colony‑forming units (CFUs) in the cord blood (CB) graft positively correlate with patient survival. Therefore, these parameters are currently used for quality assessment of the cryopreserved CB cells in the attached segment that is considered representative of the CB in the main bag prior to UCBT. Since aldehyde dehydrogenase (ALDH) activity is high in hematopoietic stem cells, the number of ALDH‑bright (ALDHbr) cells was examined in comparison with the number of CD34+ cells and CFUs for the quality assessment of CB units...
September 13, 2018: Molecular Medicine Reports
Rolla F Abu-Arja, Jamie L Dargart, Rajinder P S Bajwa, Samir B Kahwash, Jeffery J Auletta, Hemalatha G Rangarajan
AML with the RAM immunophenotype is associated with extremely poor prognosis. We report a rare case of monozygotic twins presenting simultaneously at the age of 2 years with RAM AML. Each twin underwent a myeloablative 7/10 unrelated umbilical cord blood transplant. Pretransplant Twin A's bone marrow was negative for MRD by flow cytometry (<0.01%) unlike Twin B's bone marrow (0.07%). Twin A is alive in remission 3 years from transplant. Twin B developed primary graft failure, but subsequently rescued with a haploidentical stem cell transplant...
September 15, 2018: Pediatric Transplantation
Abdolreza Babaee, Seyed Noureddin Nematollahi-Mahani, Mohammad Shojaei, Samereh Dehghani-Soltani, Massood Ezzatabadipour
Light emitting diode (LED) irradiation has recently been introduced as an encouraging strategy for promotion of cell proliferation. Human umbilical cord Wharton's jelly-derived mesenchymal (hUCM) cells are among the most available mesenchymal cells with a promising application in regenerative medicine. The aim of the present study was to examine the effect of polarized (PL) and non-polarized (NPL) red-light emitted by LED on various proliferation properties of hUCM cells. Cell proliferation was assessed 48 h after irradiation of hUCM cells by different energy densities...
September 13, 2018: Biochemical and Biophysical Research Communications
Irina Arutyunyan, Timur Fatkhudinov, Gennady Sukhikh
In this review we present current evidence on the possibility of umbilical cord tissue cryopreservation for subsequent clinical use. Protocols for obtaining umbilical cord-derived vessels, Wharton's jelly-based grafts, multipotent stromal cells, and other biomedical products from cryopreserved umbilical cords are highlighted, and their prospective clinical applications are discussed. Examination of recent literature indicates we should expect high demand for cryopreservation of umbilical cord tissues in the near future...
September 15, 2018: Stem Cell Research & Therapy
Christopher D Phillips, Pornpatcharin Wongsaisri, Thein Htut, Terry Grossman
The Editor-in-Chief is retracting this article because the authors have not obtained consent to publish from the patient whose details are described in this case report. The article has been removed to protect the patient's privacy. Terry Grossman has stated that he was not an author on this article. Christopher Phillips, Pornpatcharin Wongsaisri and Thein Htut did not reply to correspondence about this retraction.
September 14, 2018: Clinical and Translational Medicine
Rodolphe Rakic, Bastien Bourdon, Magali Demoor, Stéphane Maddens, Nathalie Saulnier, Philippe Galéra
Umbilical cord blood mesenchymal stromal/stem cells (UCB-MSCs) and umbilical cord matrix MSCs (UCM-MSCs) have chondrogenic potential and are alternative sources to standard surgically derived bone marrow or adipose tissue collection for cartilage engineering. However, the majority of comparative studies explore neonatal MSCs potential only on ISCT benchmark assays accounting for some bias in the reproducibility between in vitro and in clinical studies. Therefore, we characterized equine UCB-MSCs and UCM-MSCs and investigated with particular attention their chondrogenesis potential in 3D culture with BMP-2 + TGF-ß1 in normoxia or hypoxia...
September 14, 2018: Scientific Reports
Biao Zhou, Shunyi Nie, Te Ba, Hualei Tu, Lingfeng Wang, Shujie Wang, Quan Li, Qiong Wang
Objective: To study the antibacterial activity of human umbilical cord mesenchymal stem cells (hUCMSCs) culture supernatant and amoxicillin on Staphylococcus aureus isolated from burn wounds. Methods: The hUCMSCs were isolated from fetal umbilical cord tissue of full-term healthy fetus after cesarean section and cultured. The 3rd generation cells were divided into 4 groups which were added 0, 10, 100, and 1 000 ng/mL lipopolysaccharide (LPS), respectively; the contents of antibacterial peptide LL-37 in each group were detected by ELISA method after 6, 12, 24, and 48 hours of culture...
December 1, 2017: Chinese Journal of Reparative and Reconstructive Surgery
F Braun, A K Hardt, L Ehrlich, D M Sloboda, J R G Challis, A Plagemann, W Henrich, T Braun
INTRODUCTION: We have previously shown that even a single course of antenatal betamethasone (BET) as an inductor for lung maturity reduces birth weight and head circumference. Moreover, animal studies link BET administration to alterations of the hypothalamic-pituitary-adrenal-gland-axis (HPA). The unhindered development of the fetal HPA axis is dependent on the function and activity of 11β-hydroxysteroiddehydrogenase type 2 (11β-HSD2), a transplacental cortisol barrier. Therefore, we investigated the effects of BET on this transplacental barrier and fetal growth...
September 2018: Placenta
Le Fu, Jun Zhang, Shiyi Xiong, Minghua Sun
OBJECTIVES: The apparent diffusion coefficient (ADC) was associated with the onset of intrauterine growth restriction in singleton pregnancies. However, the correlation of ADC with selective intrauterine growth restriction (sIUGR) of monochorionic (MC) twin pregnancies remained unknown. In this study, we aimed to evaluate the association of ADC with sIUGR in MC twin pregnancies by exploring diffusion weighted MR imaging (DWI). METHODS: Fifty-one MC twin pregnancies, consisting 19 cases of sIUGR and 32 cases without sIUGR, were re-analyzed by DWI...
September 2018: Placenta
Khosro Sardarian, Amir Hossein Maghsood, Marzieh Farimani, Mehrdad Hajiloii, Massoud Saidijam, Mahsa Rezaeepoor, Hanie Mahaki, Alireza Zamani
Background: One of the consequences of toxoplasmosis is the risk of passing it from mother to fetus and the onset of congenital toxoplasmosis during pregnancy. The purpose of this study was to evaluate the B1 gene of Toxoplasma gondii in the placental tissues of pregnant women with acute toxoplasmosis. Materials and Methods: The study was a cross-sectional study. Serum samples of pregnant women who attended to Fatemieh Hospital of Hamadan University of Medical Sciences were tested for immunoglobulin G (IgG) antibodies against T...
2018: Advanced Biomedical Research
Hayley R Price, Abby C Collier, Tricia E Wright
North America is currently suffering from one of the worst epidemics of illicit drug use in recent history: the opioid crisis. Pregnant women are not immune to the ravages of substance misuse which affects themselves, their pregnancies, and the wider community. The prevalence of drug misuse in pregnancy is not well quantified due to the lack of good validated tests, cooperation between clinicians and scientists developing tests, and consensus as to who should be tested and how results should be used. A wide range of tissues can be tested for drug use, including maternal blood, urine, and hair; neonatal meconium, urine, and hair; and placenta and umbilical cord tissues...
2018: Frontiers in Pharmacology
David J Eve, Paul R Sanberg, Leonora Buzanska, Anna Sarnowska, Krystyna Domanska-Janik
Human somatic stem cells can be identified and isolated from different types of tissues and are grouped here based on their developmental maturation and ability to undergo neural differentiation. The first group will represent afterbirth somatic tissues, which are perinatal stem cells including placental blood and tissue, amniotic fluid and tissue, and umbilical cord blood- and umbilical cord tissue-derived cells. The second group of cells discussed in this chapter is the adult stem cells, generally those in a transient period of development, thus placing them in the special position of transitioning from the perinatal to young somatic tissue, and they include the menstrual blood-, the peripheral blood-, and the bone marrow-derived stem cells...
2018: Results and Problems in Cell Differentiation
Kun Niu, Hui Liu, Ruo-Wen Chen, Qi-Wu Fang, Hui Wen, Su-Mei Guo, John P Williams, Jian-Xiong An
PURPOSE: Nausea and vomiting are common, undesirable symptoms during cesarean section. We conducted this study to assess the antiemetic properties of propofol for the prevention and immediate treatment of post-delivery nausea and vomiting during cesarean section under combined spinal-epidural anesthesia. METHODS: Eighty women undergoing elective cesarean delivery under combined spinal-epidural anesthesia were randomized to receive either propofol at a plasma concentration of 1000 ng/mL or normal saline immediately after clamping of the umbilical cord...
September 12, 2018: Journal of Anesthesia
Monica K Silver, Aubrey L Arain, Jie Shao, Minjian Chen, Yankai Xia, Betsy Lozoff, John D Meeker
Early-life exposure to heavy metals and/or trace metal imbalances can have negative developmental effects. Here we sought to characterize exposure profiles for 20 heavy metals and trace elements in umbilical cord blood plasma and identify demographic predictors of exposure. Twenty metals were measured in cord plasma from 357 Chinese infants using ICP-MS. Relationships between demographic variables and metals were analyzed using generalized linear models and logistic regression. Ten metals (antimony [Sb], cobalt [Co], cesium [Cs], copper [Cu], lead [Pb], molybdenum [Mo], rubidium [Rb], selenium [Se], strontium [Sr], titanium [Ti], zinc [Zn]) were detected in all samples...
November 2018: Chemosphere
Janine S Rhoades, Victoria G Wesevich, Methodius G Tuuli, George A Macones, Alison G Cahill
OBJECTIVE:  To evaluate the implementation of an institutional protocol for universal delayed umbilical cord clamping (DCC) at term on maternal, neonatal, and umbilical cord blood gas outcomes. STUDY DESIGN:  This is a retrospective cohort study of singleton term gestations from April through July 2017. On June 1, 2017, a protocol was implemented for DCC in all deliveries. Outcomes were compared between patients delivered prior to and those delivered after implementation...
September 12, 2018: American Journal of Perinatology
Marc P O'Sullivan, Klaudia M Sikora, Caroline Ahearne, Deirdre M Twomey, Mikael Finder, Geraldine B Boylan, Boubou Hallberg, Deirdre M Murray
The role of inflammation is an important factor in the progression of hypoxic-ischaemic encephalopathy (HIE). We have previously shown that interleukin-16 (IL-16) is increased in infants with moderate and severe HIE and relates to poor neurodevelopmental outcomes. We aimed to validate IL-16 as a cord blood-based biomarker for HIE and to examine its relationship to long-term outcomes. The study sample consisted of 105 full-term infants who experienced perinatal asphyxia (PA) (with and without an encephalopathy) along with healthy, gestational age-matched newborn controls...
September 11, 2018: Developmental Neuroscience
Jenn D Bullard, Jennifer Lei, Jeremy J Lim, Michelle Massee, Anna M Fallon, Thomas J Koob
Chronic wounds are a significant health care problem with serious implications for quality of life because they do not properly heal and often require therapeutic intervention. Amniotic membrane allografts have been successfully used as a biologic therapy to promote soft tissue healing; however, the umbilical cord, another placental-derived tissue, has also recently garnered interest because of its unique composition but similar placental tissue origin. The aim of this study was to characterize PURION® PLUS Processed dehydrated human umbilical cord (dHUC) and evaluate the biological properties of this tissue that contribute to healing...
September 10, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Oscar Papazian
Hypoxic-ischemic encephalopathy is a clearly recognizable clinical syndrome of in term newborns due to fetal asphyxia at birth. The incidence is 1.5 (95% CI 1.3 to 1.7) but it ranges from 1-8 and 25 out of every 1000 born in developed and developing countries, respectively. The most frequent causes are detachment of the placenta, prolapse of the umbilical cord and uterine rupture. The diagnostic criteria include partial or total incapacity for the newborn to cry and breath at birth even when stimulated, requiring assisted ventilation in the delivery room, Apgar < 5 in 5 and 10 minutes, acidemia (pH ≤ 7 and / or bases deficit ≥ 12 mmol/l), alterations of the conscience and the reflexes of Moro, grasping and suction, muscular stretching and muscle tone...
2018: Medicina
Raghavendra Rao, Reeta Bora
No abstract text is available yet for this article.
September 5, 2018: Journal of Pediatrics
Yuhui Hao, Yonghong Ran, Binghui Lu, Jiayin Li, Jiaojiao Zhang, Chunjing Feng, Jinhui Fang, Ruoyu Ma, Zhihui Qiao, Xiaotian Dai, Wei Xiong, Jing Liu, Qi Zhou, Jie Hao, Rong Li, Jianwu Dai
PURPOSE: To investigate the effect of human umbilical cord-derived mesenchymal stem cell (MSC) transplantation on canine radiation-induced lung injury. METHODS AND MATERIALS: Beagle dogs received localized 15-Gy x-ray radiation to the right lower lung to establish the model of radiation-induced lung injury. After 180 days, dogs were divided into 2 groups (4 per group). The MSC group received intratracheal MSC transplantation, and the saline group received the same volume of normal saline by lavage...
October 1, 2018: International Journal of Radiation Oncology, Biology, Physics
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