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https://www.readbyqxmd.com/read/29244789/pigment-epithelium-derived-factor-from-arpe19-promotes-proliferation-and-inhibits-apoptosis-of-human-umbilical-mesenchymal-stem-cells-in-serum-free-medium
#1
Dah-Ching Ding, Yao-Tseng Wen, Rong-Kung Tsai
Clinical expansion of mesenchymal stem cells (MSCs) is hampered by the lack of knowledge regarding how to prevent MSC apoptosis and promote their proliferation in serum-free medium. Our in vitro studies demonstrated that human umbilical cord MSCs (HUCMSCs) underwent apoptosis in the serum-free medium. When HUCMSCs were co-cultured with retinal pigment epithelial cells (ARPE19), however, HUCMSCs exhibited normal growth and morphology in serum-free medium. Their colony formation was promoted by the conditioned medium (CM) of ARPE19 cells on Matrigel...
December 15, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29244714/identification-of-novel-human-nk-cell-progenitor-subsets
#2
Priyanka Sathe, Swee Heng Milon Pang, Rebecca Delconte, Ngaire Elwood, Nicholas D Huntington
Understanding the pathways and regulation of human haematopoiesis, in particular, lymphopoiesis, is vital to manipulation of these processes for therapeutic purposes. However, although haematopoiesis has been extensively characterised in mice, translation of these findings to human biology remains rudimentary. Here, we describe the isolation of three progenitor subsets from human foetal bone marrow that represent differential stages of commitment to the natural killer (NK) cell lineage based on IL-15 responsiveness...
December 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29242852/prospective-study-of-nonmyeloablative-hla-mismatched-unrelated-bmt-with-high-dose-posttransplantation-cyclophosphamide
#3
Yvette L Kasamon, Richard F Ambinder, Ephraim J Fuchs, Marianna Zahurak, Gary L Rosner, Javier Bolaños-Meade, Mark J Levis, Douglas E Gladstone, Carol Ann Huff, Lode J Swinnen, William H Matsui, Ivan Borrello, Robert A Brodsky, Richard J Jones, Leo Luznik
Allogeneic blood or marrow transplantation (BMT) candidates may lack HLA-matched, related haploidentical, and unrelated umbilical cord options. Barriers to partially HLA-mismatched, unrelated donor (mMUD) BMT include excess graft-versus-host disease (GVHD), graft failure, and death. We prospectively studied nonmyeloablative (NMA) mMUD BMT with high-dose posttransplantation cyclophosphamide (PTCy) for patients with hematologic malignancies. Three transplants were performed with busulfan/fludarabine conditioning, with subsequent change to fludarabine/Cy/total body irradiation (flu/Cy/TBI)...
2017: Blood Advances
https://www.readbyqxmd.com/read/29242640/effects-of-maternal-obesity-on-wharton-s-jelly-mesenchymal-stromal-cells
#4
Heba Badraiq, Aleksandra Cvoro, Antonio Galleu, Marisa Simon, Cristian Miere, Carl Hobbs, Reiner Schulz, Richard Siow, Francesco Dazzi, Dusko Ilic
We investigated whether maternal metabolic environment affects mesenchymal stromal/stem cells (MSCs) from umbilical cord's Wharton's Jelly (WJ) on a molecular level, and potentially render them unsuitable for clinical use in multiple recipients. In this pilot study on umbilical cords post partum from healthy non-obese (BMI = 19-25; n = 7) and obese (BMI ≥ 30; n = 7) donors undergoing elective Cesarean section, we found that WJ MSC from obese donors showed slower population doubling and a stronger immunosuppressive activity...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29242152/human-umbilical-cord-derived-mesenchymal-stem-cells-protect-from-hyperoxic-lung-injury-by-ameliorating-aberrant-elastin-remodeling-in-the-lung-of-o2-exposed-newborn-rat
#5
Chen Hou, Danyi Peng, Li Gao, Daiyin Tian, Jihong Dai, Zhengxiu Luo, Enmei Liu, Hong Chen, Lin Zou, Zhou Fu
The incidence and mortality rates of bronchopulmonary dysplasia (BPD) remain very high. Therefore, novel therapies are imminently needed to improve the outcome of this disease. Human umbilical cord-derived mesenchymal stem cells (UC-MSCs) show promising therapeutic effects on oxygen-induced model of BPD. In our experiment, UC-MSCs were intratracheally delivered into the newborn rats exposed to hyperoxia, a well-established BPD model. This study demonstrated that UC-MSCs reduce elastin expression stimulated by 90% O2 in human lung fibroblasts-a (HLF-a), and inhibit HLF-a transdifferentiation into myofibroblasts...
December 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29241965/perinatal-hemorrhage-from-ulceration-of-the-umbilical-cord-a-potentially-catastrophic-association-with-duodenal-and-jejunal-obstruction
#6
Danielle Aronowitz, Stephen Dolgin, Eran Bornstein, Amanda Little-Richardson, Jaya Bajaj, Alex Williamson, Esperanza Naves-Ruiz, Morris Edelman
PURPOSE: The purpose of this study is to review published reports and contribute new cases of umbilical cord ulceration (UCU) with perinatal hemorrhage into the amniotic cavity in the setting of duodenal or jejunal obstruction because knowledge of this sequence is poorly disseminated and could be lifesaving. METHODS: Published reports of UCU with hemorrhage associated with congenital duodenal or jejunal obstruction were reviewed. Chart review was conducted for the cases encountered at our institutions between January 2008 and March 2017...
November 21, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29241934/fetoplacental-cytogenetic-discrepancy-in-a-pregnancy-with-fetal-mosaic-tetrasomy-12p-and-pallister-killian-syndrome-detected-by-amniocentesis
#7
Chih-Ping Chen, Liang-Kai Wang, Schu-Rern Chern, Peih-Shan Wu, Shin-Wen Chen, Shih-Ting Lai, Tzu-Yun Chuang, Li-Feng Chen, Wayseen Wang
OBJECTIVE: We present fetoplacental cytogenetic discrepancy in a pregnancy with prenatally detected mosaic tetrasomy 12p by amniocentesis. CASE REPORT: A 34-year-old woman underwent amniocentesis at 17 weeks of gestation because of advanced maternal age. Cytogenetic analysis of cultured amniocytes revealed a karyotype of 47,XX,+i(12)(p10)[7]/46,XX[16]. Array comparative genomic hybridization (aCGH) analysis of the DNA extracted from cultured amniocytes revealed arr (12p)×3, (X)×2...
December 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29241927/prenatal-diagnosis-of-a-1-6-mb-4p16-3-interstitial-microdeletion-encompassing-fgfrl1-and-tacc3-associated-with-bilateral-cleft-lip-and-palate-of-wolf-hirschhorn-syndrome-facial-dysmorphism-and-short-long-bones
#8
Chih-Ping Chen, Chen-Yu Chen, Schu-Rern Chern, Peih-Shan Wu, Shin-Wen Chen, Shih-Ting Lai, Tzu-Yun Chuang, Chien-Wen Yang, Li-Feng Chen, Wayseen Wang
OBJECTIVE: We present prenatal diagnosis of a 4p16.3 interstitial microdeletion associated with bilateral cleft lip and palate and short long bones on prenatal ultrasound, and we discuss the genotype-phenotype correlation. MATERIALS AND METHODS: A 32-year-old woman underwent amniocentesis at 22 weeks of gestation because of bilateral cleft lip and palate and short limbs on prenatal ultrasound. Conventional cytogenetic analysis was performed on cultured amniocytes and parental bloods...
December 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29241913/the-comparison-of-umbilical-cord-arterial-blood-lactate-and-ph-values-for-predicting-short-term-neonatal-outcomes
#9
Ruta Einikyte, Vilija Snieckuviene, Diana Ramasauskaite, Jurate Panaviene, Virginija Paliulyte, Gina Opolskiene, Edita Kazenaite
OBJECTIVE: Current clinical practice of assessing neonatal condition is based on evaluation of umbilical cord arterial blood pH value rather than lactate. However, evidence shows that lactate is direct and more predictive measurement than pH or at least of equal importance. This study is to assess and compare umbilical cord arterial lactate and pH values for predicting short-term neonatal outcomes. MATERIALS AND METHODS: A retrospective cohort study was conducted at the tertiary level hospital, were arterial umbilical cord blood sampling was collected according to the standard procedures...
December 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29241465/-delayed-umbilical-cord-separation
#10
H Theeuwen, J van der Sluijs, M Nanlohy-Manuhutu
We present the case report of a preterm infant with delayed umbilical cord separation. At the age of four weeks the umbilical cord separation had still not occurred. The umbilical cord tissue sometimes seemed wet and did not dry completely. There were no signs of immunodeficiency. An ultrasound of the abdomen showed a small urachal cyst. No further intervention was indicated.
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29241065/associations-between-maternal-triclosan-concentrations-in-early-pregnancy-and-gestational-diabetes-mellitus-impaired-glucose-tolerance-gestational-weight-gain-and-fetal-markers-of-metabolic-function
#11
Gabriel D Shapiro, Tye E Arbuckle, Jillian Ashley-Martin, William D Fraser, Mandy Fisher, Maryse F Bouchard, Patricia Monnier, Anne-Sophie Morisset, Adrienne S Ettinger, Linda Dodds
BACKGROUND: Triclosan is a phenolic biocide used in a multitude of consumer products and in health care settings. It is widely detected in the American and Canadian populations and has been shown in animal models to act as an endocrine disrupting agent. However, there has been little examination to date of the effects of triclosan exposure in pregnancy on perinatal metabolic outcomes in human populations. METHODS: Using data from the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, a Canadian pregnancy cohort, we measured associations of first-trimester urinary triclosan concentrations with total gestational weight gain, gestational diabetes mellitus and impaired glucose tolerance in pregnancy, and fetal markers of metabolic function...
December 11, 2017: Environmental Research
https://www.readbyqxmd.com/read/29239794/use-of-hydrotherapy-during-labour-assessment-of-pain-use-of-analgesia-and-neonatal-safety
#12
Laura Mallen-Perez, M Teresa Roé-Justiniano, Núria Colomé Ochoa, Alicia Ferre Colomat, Montse Palacio, Carme Terré-Rull
AIM: To evaluate the effectiveness of the use of hydrotherapy in pain perception and requesting analgesia in women who use hydrotherapy during childbirth and to identify possible adverse effects in infants born in water. METHOD: A multicentre prospective cohort study was performed between September 2014 and April 2016. A total of 200 pregnant women were selected and assigned to the hydrotherapy group (HG) or the control group (CG) according to desire and availability of use, data collection started at 5cm dilatation...
November 24, 2017: Enfermería Clínica
https://www.readbyqxmd.com/read/29239485/comparison-of-umbilical-cord-occlusion-methods-radiofrequency-ablation-versus-laser-photocoagulation
#13
Mira Abdel-Sattar, Andrew H Chon, Arlyn Llanes, Lisa M Korst, Joseph G Ouzounian, Ramen H Chmait
OBJECTIVE: To compare outcomes between two umbilical cord occlusion (UCO) methods: radiofrequency ablation (RFA) versus fetoscopic-guided laser photocoagulation. METHODS: Retrospective study of all monochorionic diamniotic multiple gestations that underwent UCO with RFA (preferred after 2014) or laser (preferred before 2014). In bivariate analysis, patients treated with RFA were compared to laser. Risk factors for intrauterine fetal demise (IUFD) and 30-day survival of the co-twin were identified, and multiple logistic models were fitted to examine whether the UCO method was associated with these outcomes...
December 14, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29238669/use-of-amnion-chorion-and-umbilical-cord-grafts-in-conjunction-with-penile-implant-procedures
#14
Andrew C Kramer
Biologics have increased in popularity lately as a novel and exciting new therapy for men with a spectrum of sexual dysfunction ailments-ranging from erectile dysfunction, Peyronie's disease, and ejaculatory disorders. In this series, sequential patients were analyzed who received biologic materials at the time of their penile implant surgery, with various metrics assessed. The information gathered includes recovery time, need for postoperative analgesics, and satisfaction with the final outcome. In this study, early metrics appear to point to improved outcomes in select criteria...
November 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29238069/kynurenic-acid-an-ido-metabolite-controls-tsg-6-mediated-immunosuppression-of-human-mesenchymal-stem-cells
#15
Guan Wang, Kai Cao, Keli Liu, Yueqing Xue, Arthur I Roberts, Fengying Li, Yanyan Han, Arnold B Rabson, Ying Wang, Yufang Shi
Mesenchymal stem cells (MSCs) have been demonstrated to be anti-inflammatory against various immune disorders through several factors, including indoleamine 2,3-dioxygenase (IDO) and TNF-stimulated gene 6 (TSG-6). However, little is known about the necessity for both of these key immunosuppressive factors. Here we employed the mouse lipopolysaccharide (LPS)-induced acute lung injury (ALI) model, and found that IDO is necessary to achieve the effect of human umbilical cord-derived MSC (hUC-MSC)-based treatment on ALI...
December 13, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29237307/oligohydramnios-is-an-independent-risk-factor-for-perinatal-morbidity-among-women-with-preeclampsia-who-delivered-preterm
#16
Alex Rabinovich, Keren Holtzman, Ilana Shoham-Vardi, Moshe Mazor, Offer Erez
PURPOSE: Determine the relationship between oligohydramnios and adverse maternal and neonatal outcomes in a unique cohort of preterm preeclamptic patients. MATERIALS AND METHODS: A retrospective matched case control study comparing 81 preterm parturients (28 0/7 and 36 6/7 weeks) with preeclampsia and oligohydramnios to 81 preterm preeclamptic patients with a normal amniotic fluid index (AFI). RESULTS: 4.8 percent of all our preterm preeclamptic patients had oligohydramnios...
December 13, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29236838/birth-plan-compliance-and-its-relation-to-maternal-and-neonatal-outcomes
#17
Pedro Hidalgo-Lopezosa, María Hidalgo-Maestre, Maria Aurora Rodríguez-Borrego
OBJECTIVE: to know the degree of fulfillment of the requests that women reflect in their birth plans and to determine their influence on the main obstetric and neonatal outcomes. METHOD: retrospective, descriptive and analytical study with 178 women with birth plans in third-level hospital. Inclusion criteria: low risk gestation, cephalic presentation, single childbirth, delivered at term. Scheduled and urgent cesareans without labor were excluded. A descriptive and inferential analysis of the variables was performed...
December 11, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/29235254/mesenchymal-stem-cells-a-double-edged-sword-in-radiation-induced-lung-injury
#18
Yi Yao, Zhongliang Zheng, Qibin Song
Radiation therapy is an important treatment modality for multiple thoracic malignancies. However, radiation-induced lung injury (RILI), which is the term generally used to describe damage to the lungs caused by exposure to ionizing radiation, remains a critical issue affecting both tumor control and patient quality of life. Despite tremendous effort, there is no current consensus regarding the optimal treatment approach for RILI. Because of a number of functional advantages, including self-proliferation, multi-differentiation, injury foci chemotaxis, anti-inflammation, and immunomodulation, mesenchymal stem cells (MSCs) have been a focus of research for many years...
December 13, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/29234502/nuchal-cord-and-its-implications
#19
REVIEW
Morarji Peesay
Nuchal cord occurs when the umbilical cord becomes wrapped around the fetal neck 360 degrees. Nuchal cords occur in about 10-29% of fetuses and the incidence increases with advancing gestation age. Most are not associated with perinatal morbidity and mortality, but a few studies have shown that nuchal cord can affect the outcome of delivery with possible long-term effects on the infants. Nuchal cords are more likely to cause problems when the cord is tightly wrapped around the neck, with effects of a tight nuchal cord conceptually similar to strangulation...
2017: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/29234147/whole-blood-volumes-associated-with-milking-intact-and-cut-umbilical-cords-in-term-newborns
#20
Ryan M McAdams, Emily Fay, Shani Delaney
OBJECTIVE: The objective of this study is to determine placental transfusion blood volumes with intact and cut umbilical cord milking in term newborns. STUDY DESIGN: Sixty women at ≥37 weeks' gestation were enrolled. Following delivery, the umbilical cord was immediately clamped and cut to separate the newborn. Either intact umbilical cord milking (I-UCM) of the placental-umbilical cord unit or cut umbilical cord milking (C-UCM) of the cut umbilical cord segment was performed...
December 12, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
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