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https://www.readbyqxmd.com/read/28412265/one-stage-supramaximal-full-thickness-wedge-resection-of-vascular-lip-anomalies
#1
Dawn K De Castro, Zhi Yang Ng, Paul W Holzer, Milton Waner, Curtis L Cetrulo, Aaron Fay
PURPOSE: Vascular lip anomalies include infantile hemangiomas, venous malformations, and arteriovenous malformations. Surgical management can be complicated by alterations in horizontal length, vertical height, and lip thickness from the underlying pathology. Additional reconstructive challenges include preservation of oral continence, vermillion definition, and the sublabial sulcus. This report describes a technique of supramaximal single-stage full-thickness wedge resection of these lesions...
March 22, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28406466/artificial-red-blood-cells-as-potential-photosensitizers-in-dye-laser-treatment-against-port-wine-stains
#2
REVIEW
Naoaki Rikihisa, Shoji Watanabe, Yoshiaki Saito, Hiromi Sakai
We suggest a novel method that uses artificial blood cells (hemoglobin vesicles, Hb-Vs) as photosensitizers in dye laser treatment (at 595-nm wavelength) for port-wine stains (i.e., capillary malformations presenting as red birthmarks) based on the results of animal experiments. As compared with human red blood cells, Hb-Vs have the same absorbance of 595 nm wavelength light and produce the same level of heat following dye laser irradiation. Small sized Hb-Vs (250 nm) distribute in the plasma phase in blood and tend to flow in the marginal zone of microvessels...
April 13, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28388282/combined-pulsed-dye-laser-and-fiberoptic-nd-yag-laser-for-the-treatment-of-hypertrophic-port-wine-stain
#3
Mohammed Radmanesh, Ramin Radmanesh
The hypertrophic port wine stain (PWS) is only partially and superficially treated with the Pulsed dye laser(PDL) because of its limited depth of penetration. We used combined PDL and fiberoptic 1444nm Nd-YAG laser to treat a case with hypertrophic PWS. METHOD: After tumescent anesthesia, few holes were made by a 16 gauge needle on different sides of the lesion. The fiberoptic tip was of 1444nm Nd-YAG laser was inserted within the holes and was pushed forward while triggering. In a fan pattern and by a back and forth movement, the subcutaneous and deep dermal areas were coagulated...
April 7, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28360970/pediatric-dermatology
#4
REVIEW
Leslie Castelo-Soccio, Patrick McMahon
Skin changes are common in children. Common concerns are birthmarks (e.g., hemangiomas and port wine stains), atopic and contact dermatitis, acne, and alopecia areata. The authors review advances in common and not so common skin changes in pediatric patients.
March 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28216012/the-association-between-treatment-reactions-and-treatment-efficiency-of-hmme-photodynamic-therapy-on-port-wine-stains-a-prospective-double-blind-randomized-controlled-trial
#5
Yan Tang, Hongfu Xie, Ji Li, Dan Jian
BACKGROUND: Plenty of researches focused on treatment efficiency and/or treatment reactions of photodynamic therapy (PDT) on port-wine stain (PWS). But few studies reported the association between them. Hence, here we investigated the association between the treatment efficiency and treatment reactions after Hemoporfin mediated photodynamic therapy (HMME-PDT) on PWS through a prospective study. METHODS: Patients (n=50) with PWS were randomly assigned to the HMME group or the placebo group...
February 12, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28160203/nd-yag-laser-induced-morphology-change-and-photothermal-conversion-of-gold-nanorods-with-potential-application-in-the-treatment-of-port-wine-stain
#6
Linzhuang Xing, Bin Chen, Dong Li, Jun Ma, Wenjuan Wu, Guoxiang Wang
Based on the principle of selective photothermolysis, 1064 nm Nd:YAG laser has great potential for the treatment of deeper and larger PWS. However, the clinical effectiveness is limited because of the weak absorption of blood to Nd:YAG laser. The aim of this study is to obtain the optimal irradiation conditions to effectively destroy vascular lesions with the assistance of PEG-modified gold NRs to enhance blood absorption of Nd:YAG laser. In our study, PEG-modified gold NRs were prepared by the seeded growth method...
April 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28126187/sturge-weber-syndrome-a-review
#7
E Higueros, E Roe, E Granell, E Baselga
Sturge-Weber syndrome is a sporadic congenital neurocutaneous disorder caused by a somatic activating mutation in GNAQ; it affects 1 in every 20,000 to 50,000 newborns. It is characterized by a facial Port-wine stain, leptomeningeal angiomatosis, and glaucoma. Seizures are the most common neurological manifestation and typically present in the first months of life. Glaucoma may be present at birth or develop later. Neuroimaging studies show leptomeningeal angiomatosis, supporting diagnosis. Standard treatment for Sturge-Weber syndrome includes laser treatment for the Port-wine stain, anticonvulsants, and medical or surgical treatment for the glaucoma...
January 23, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28107576/non-invasive-anaesthetic-methods-for-dermatological-laser-procedures-a-systematic-review
#8
REVIEW
K Greveling, E P Prens, L Liu, M B A van Doorn
Pain is a common side-effect of dermatological laser procedures. Non-invasive anaesthetic drugs and anaesthetic procedures can be used to provide pain relief and increase patient satisfaction and treatment efficacy. However, it remains unclear which method provides the best pain relief. The objective of this systematic review was therefore to assess the efficacy and safety of non-invasive anaesthetic methods during dermatological laser procedures. A systematic literature search was conducted. Randomized and non-randomized controlled clinical trials (RCTs and CCTs) were included...
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28091849/dynamic-optical-absorption-characteristics-of-blood-after-slow-and-fast-heating
#9
Hao Jia, Bin Chen, Dong Li
Laser treatment is the most effective therapy in dermatology for vascular skin disorders, such as port-wine stains (PWS). Changes in heat-induced absorbance in blood must be determined for accurate numerical simulation and implementation of multi-pulse laser therapy for treatment of PWS. Thermally induced absorbance changes in hemoglobin in blood were compared in vitro between slow water bath heating and fast heating irradiated by using sub-millisecond Nd:YAG laser. Blood composition at different temperatures was calculated by comparing blood absorption spectra with those of pure HbO2, Hb, and metHb at room temperature...
April 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28088993/treatment-of-recalcitrant-port-wine-stains-pws-using-a-combined-pulsed-dye-laser-pdl-and-radiofrequency-rf-energy-device
#10
Yoon-Soo Cindy Bae, Hamad Alabdulrazzaq, Jeremy A Brauer, Roy G Geronemus
BACKGROUND: Pulsed dye laser (PDL) is the treatment of choice for port-wine stains (PWS). Some PWS are recalcitrant to this modality. A number of reasons for PDL treatment resistance have been described, including inadequate heat generation. OBJECTIVE: We evaluated PDL combined with radiofrequency (RF) energy into a single device to target larger and deeper blood vessels and overcome PDL resistance. METHOD: This was an open-label, prospective, single-center investigation of a novel device combining RF energy with PDL conducted to treat recalcitrant PWS...
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28030367/activation-of-pkc%C3%AE-and-pi3k-kinases-in-hypertrophic-and-nodular-port-wine-stain-lesions
#11
Rong Yin, Lin Gao, Wenbin Tan, Wei Guo, Tao Zhao, Jhon Stuart Nelson, Gang Wang
Port wine stain (PWS) is a congenital, progressive vascular malformation. Many patients with PWS develop hypertrophy and discrete nodularity during their adult life, but the mechanism(s) remain incompletely understood. In this study, we attempted to investigate activation status of PKCα, PI3K, PDPK1 and PLC-γ and protein levels of PP2A and DAG to explore their potential roles in the formation of hypertrophic and nodular PWS lesions. We found phosphorylated levels of PKCα, PI3K, PDPK1, and PLC-γ and protein levels of PP2A and DAG showed moderate increases in the endothelial cells of hypertrophic PWS as compared to the adjacent normal skin...
December 20, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27955934/quality-of-life-in-adults-with-facial-port-wine-stains
#12
Solveig L Hagen, Katherine R Grey, Dorota Z Korta, Kristen M Kelly
BACKGROUND: Facial port-wine stains (PWS) are considered by some an aesthetic skin problem, yet impact on quality of life (QoL) has not been objectively documented. OBJECTIVE: We sought to (1) characterize the effect of PWS on QoL in adults, (2) to identify the clinical and demographic factors that affect QoL, and (3) to compare our results with QoL studies in other skin conditions. METHODS: In total, 244 adults with facial PWS completed an online QoL survey, which included the Skindex-29 instrument...
December 9, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27941746/klippel-trenaunay-syndrome-a-case-report
#13
M N Islam, M A Hossain, M S Rahman, T Tazmin, M A Ali, F Sultana, S A Haque
Klippel Trenaunay syndrome refers to a rare congenital anomaly which is characterized by capillary malformation, venous malformation and sometimes lymphatic malformation associated with overgrowth of a limb, with soft tissue hypertrophy and/or bony hypertrophy. The anomaly, if present, is present at birth and usually involves the lower limbs as well as portion of trunk, face, uppper limb or head. Our reporting case is a preterm male neonate having port wine stain, varicose veins and excessive growth of soft tissue of left lower limb clinically consistent with Klippel Trenaunay Syndrome...
October 2016: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/27885298/klippel-trenaunay-syndrome-a-case-report
#14
R K Sah, S Sharma, S Ghimire, B B Bagale, M Kayastha, R H Chapagain
Klippel-Trenaunaysyndrome(KTS) is a rare congenital condition usually presenting with port wine stains, excessive growth of bones and soft tissue and varicose veins which most commonly occurs in the legs, but it also may affect the arms, face, head, or internal organs. We report a case of term male neonate with clinical findings of Port-wine stain, multiple cystic swellings with ultrasonographic findings suggestive of vascular malformations and limb abnormalities in the form ofsoft tissue hypertrophy of right upper limb, polydactyly of right hand and syndactyly of left hand consistent withKlippel-Trenaunay syndrome...
May 2016: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/27795889/sturge-weber-syndrome-with-intracerebral-hemorrhage-a-case-report
#15
Masashi Chonan, Yasuhiro Suzuki, Shinya Haryu, Shoji Mashiyama, Teiji Tominaga
INTRODUCTION: Sturge-Weber syndrome (SWS) is a rare congenital disease that affects the brain, skin, and eyes, and is a sporadically occurring neurocutaneous syndrome that affects intracerebral veins, which is associated with venous thrombosis. However, intracranial hemorrhage in patients with SWS is rare. We herein report a rare case of SWS with intracerebral hemorrhage derived from sinus thrombosis. CASE DESCRIPTION: A 62-year-old man suddenly fell into a coma and was admitted to our hospital...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27716384/ion-channels-expression-and-function-are-strongly-modified-in-solid-tumors-and-vascular-malformations
#16
Antonella Biasiotta, Daniela D'Arcangelo, Francesca Passarelli, Ezio Maria Nicodemi, Antonio Facchiano
BACKGROUND: Several cellular functions relate to ion-channels activity. Physiologically relevant chains of events leading to angiogenesis, cell cycle and different forms of cell death, require transmembrane voltage control. We hypothesized that the unordered angiogenesis occurring in solid cancers and vascular malformations might associate, at least in part, to ion-transport alteration. METHODS: The expression level of several ion-channels was analyzed in human solid tumor biopsies...
October 4, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27669109/split-lesion-randomized-comparative-study-between-long-pulsed-nd-yag-laser-532-and-1-064%C3%A2-nm-in-treatment-of-facial-port-wine-stain
#17
Muhsin A Al-Dhalimi, Murtadha H Al-Janabi
BACKGROUND: Lasers have been the treatment of choice for Port-wine stain (PWS). However, only one type of laser is not a panacea for all PWS malformations. This is may be due to the great heterogeneity of phenotypic presentation of this congenital anomaly as color, depth, and the site of the lesion. For the treatment of PWS, flash lamp-pumped pulsed dye laser, carbon dioxide, argon, krypton, copper bromide, frequency-doubled neodymium:yttrium-aluminum-garnet (Nd:YAG), and also intense pulsed light sources can be used...
November 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27637568/predictive-factors-for-epilepsy-in-pediatric-patients-with-sturge-weber-syndrome
#18
Matsanga Leyila Kaseka, Jonathan Yehouda Bitton, Jean-Claude Décarie, Philippe Major
BACKGROUND: Sturge-Weber syndrome is characterized by a facial port-wine stain associated with either or both a retinal angioma and a cerebral pial angioma. Because a pial angioma may not be evident on the initial imaging studies, individuals at risk for epilepsy are often not identified before their first seizure. The aim of this study is to identify predictive factors predisposing Sturge-Weber patients to epilepsy. METHODS: The medical archives and photography database of our institution were reviewed to identify Sturge-Weber Syndrome patients followed up between 1990 and 2015...
November 2016: Pediatric Neurology
https://www.readbyqxmd.com/read/27557468/combination-of-sturge-weber-syndrome-and-trigonocephaly
#19
Oliver Ristow, Christian Freudlsperger, Moritz Berger, Heidi Bächli, Jürgen Hoffmann, Michael Engel
Regarded singly, both Sturge-Weber syndrome and trigonocephaly are rare congenital disorders. The cardinal features of Sturge-Weber syndrome are facial cutaneous capillary malformation (port-wine stain), leptomeningeal angiomatosis, and glaucoma. Premature closure of the metopic suture results in trigonocephaly. However, to the best of our knowledge, the diagnosis of a combination of both Sturge-Weber syndrome and trigonocephaly has not as yet been reported. This brief clinical study thus presents a patient with the unusual findings of a Sturge-Weber syndrome and simultaneous trigonocephaly induced by premature metopic synostosis...
October 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27555719/unilateral-glaucoma-associated-with-conjunctival-angioma-and-choroidal-thickening-without-facial-angioma
#20
Osamah J Saeedi, Luke Y Chang, Karun S Arora, Henry D Jampel, Harry A Quigley
We report a case of a suspected Sturge-Weber syndrome variant diagnosed at the age of 58 with the help of enhanced depth imaging spectral-domain ocular coherence tomography (EDI-SDOCT). A 58-year-old female with unilateral glaucoma was suspected to have choroidal vascular lesion, conjunctival angioma, and no facial port-wine stain who presented to the clinic with bleb dysesthesia many years after trabeculectomy. EDI-SDOCT was performed and revealed markedly increased choroidal thickness in the affected eye...
July 2016: Middle East African Journal of Ophthalmology
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