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Port wine stains

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https://www.readbyqxmd.com/read/28724825/a-rare-case-of-overlapping-sturge-weber-syndrome-and-klippel-trenaunay-syndrome-associated-with-bilateral-refractory-childhood-glaucoma
#1
Manju R Pillai, P P Hasini, Ashish Ahuja, S R Krishnadas
A 6-year-old girl presented with blurred vision and was found to have elevated intraocular pressure (IOP) and glaucomatous optic disc damage in both eyes. She also displayed capillary malformations on the face (port-wine stain), upper back and all four limbs, angiomatosis in the brain and had hypertrophy of the left upper and lower limbs typical of overlapping Sturge-Weber syndrome and Klippel-Trenaunay syndromes. She was initially managed with IOP lowering topical medications but required trabeculectomy in the right eye followed by Ahmed valve implantation in both eyes...
July 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28705519/acquired-port-wine-stain-fegeler-syndrome-a-report-of-3-cases
#2
J F Millán-Cayetano, J Del Boz, P García-Montero, M de Troya-Martín
No abstract text is available yet for this article.
July 11, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28698417/-intravenous-ablation-for-lower-extremity-varices-to-prevent-recurrent-pulmonary-embolism-in-klippel-trenaunay-syndrome-report-of-a-case
#3
Ikutaro Kigawa, Masahiro Aiba, Atsushi Ito
Klippel-Trenaunay syndrome( KTS) is a complex congenital anomaly characterized by lower extremity varix and venous malformations, port-wine stains, and soft tissue and bone hypertrophy. We present a case of a 35-year-old man of KTS with pulmonary embolism (PE). The patient was referred to our hospital complaining of the leg pain and sudden onset of dyspnea. Enhanced computed tomography (CT) showed lower extremity varices, superficial thrombophlebitis and bilateral pulmonary thrombi. No venous malformations except for varicose veins were revealed in the limbs or pelvis...
July 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28681520/a-hairy-port-wine-stain-with-overlying-hyperhidrosis-on-the-thigh-of-a-child
#4
Vishal Gupta, Saurabh Bhatia, Sudheer Arava, Vinod K Sharma
No abstract text is available yet for this article.
July 6, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28663834/dermoscopy-guided-dark-field-multi-functional-optical-coherence-tomography
#5
Soonjae Kwon, Yeoreum Yoon, Bumju Kim, Won Hyuk Jang, Byungho Oh, Kee Yang Chung, Ki Hean Kim
Dermoscopy is a skin surface microscopic technique allowing specular reflection free observation of the skin, and has been used to examine pigmented skin lesions. However, dermoscopy has limitations in providing depth information due to lack of 3D resolution. In order to overcome the limitations, we developed dermoscopy guided multi-functional optical coherence tomography (MF-OCT) providing both high-contrast superficial information and depth-resolved structural, birefringent, and vascular information of the skin simultaneously...
March 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28657379/a-new-imaging-technique-for-assessment-of-the-effectiveness-of-long-pulse-nd-yag-532-nm-laser-in-treatment-of-facial-port-wine-stain
#6
Murtadha Hashim Al-Janabi, Noor Taha Ismaeel Ali, Karrar Dheiaa Mohammed, Muhsin A Al-Dhalimi, Sahib Neamh Abdul Wahid
BACKGROUND: PWS is a vascular malformation presented at birth and associated with a psychological problem to the patients. Many types the laser systems were used to solve this problem. AIM OF THE STUDY: to assess the efficacy of long-pulsed Nd:YAG 532 nm for the treatment of port wine stain both clinically and by imaging technique. PATIENTS AND METHODS: This is an Interventional therapeutic clinical study for the treatment of facial port-twine stain with long-pulsed, 532nm, Nd:YAG laser...
June 28, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28652904/successful-treatment-of-unilateral-klippel-trenaunay-syndrome-with-pulsed-dye-laser-in-a-2-week-old-infant
#7
Hoda Rahimi, Habib Hassannejad, Hamideh Moravvej
Introduction: Klippel-Trenaunay syndrome (KTS) is a rare congenital mesodermal abnormality characterized by varicose veins, cutaneous capillary malformation, as well as bone and soft tissue hypertrophy. Case Report: A 2-week-old female infant presented to our clinic because of vascular nevus and progressive enlargement of her right extremities and trunk since birth. The patient was treated with 595-nm pulsed-dye laser (PDL). Her port-wine stain (PWS) disappeared completely after third PDL session and the soft tissue hypertrophy stopped...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/28650740/in-vivo-investigation-of-the-safety-and-efficacy-of-pulsed-dye-laser-with-two-spot-sizes-in-port-wine-stain-treatment-a-prospective-side-by-side-comparison
#8
Wenxin Yu, Hanru Ying, Yijie Chen, Yajing Qiu, Hui Chen, Yunbo Jin, Xi Yang, Tianyou Wang, Gang Ma, Xiaoxi Lin
OBJECTIVE: Pulsed dye laser (PDL) with 7 and 10 mm spot sizes is widely used on a regular basis for the treatment of port-wine stain (PWS). BACKGROUND DATA: No studies have reported on the differences in efficacy outcomes resulting from the use of different laser spot sizes in the treatment of PWS by PDL. Thus, an in vivo investigation into the differences in safety and efficacy of treatment between two spot sizes (7 mm vs. 10 mm) of PWS by PDL was conducted...
May 31, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28647616/photodynamic-therapy-in-dermatology-beyond-non-melanoma-cancer-an-update
#9
REVIEW
Xiang Wen, Yong Li, Michael R Hamblin
Photodynamic therapy (PDT) employs a photosensitizer (PS) and visible light in the presence of oxygen, leading to production of cytotoxic reactive oxygen species, which can damage the cellular organelles and cause cell death. In dermatology PDT has usually taken the form of topical application of a precursor in the heme biosynthesis pathway, called 5-aminolevulinic acid (or its methyl ester), so that an active PS, protoporphyrin IX accumulates in the skin. As PDT enhances dermal remodeling and resolves chronic inflamation, it has been used to treat cutaneous disorders include actinic keratoses, acne, viral warts, skin rejuvenation, psoriasis, localized scleroderma, some non-melanoma skin cancers and port-wine stains...
June 21, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28623992/near-infrared-fluorescence-lymphatic-imaging-of-klippel-tr%C3%A3-naunay-syndrome
#10
John C Rasmussen, Rodrick C Zvavanjanja, Melissa B Aldrich, Matthew R Greives, Eva M Sevick-Muraca
The relationship between lymphatic and venous malformations in Klippel-Trénaunay syndrome is difficult to assess. Herein the authors describe near-infrared fluorescence lymphatic imaging to assess the lymphatics of a subject with a large port-wine stain and right leg edema. Although lymphatic vessels in the medial, affected knee appeared dilated and perhaps tortuous, no definitive abnormal lymphatic pooling or propulsion was observed. The lymphatics in the affected limb were well defined but less numerous than in the contralateral limb, and active, contractile function was observed in all vessels...
July 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28599054/coexistence-of-ephb1-and-ephrinb2-in-port-wine-stain-endothelial-progenitor-cells-contributes-to-clinicopathological-vasculature-dilatation
#11
W Tan, J Wang, F Zhou, L Gao, Y Rong, H Liu, A Sukanthanag, G Wang, M C Mihm, D-B Chen, J S Nelson
Port wine stain (PWS) is a vascular malformation characterized by a progressive dilatation of post-capillary venules, but the molecular pathogenesis remains obscure. We hypothesized that PWS endothelial cells (ECs) present a unique molecular phenotype that lead to pathoanatomic PWS vasculatures. We herein show multiple clinicopathologic features of PWS blood vessels during the development and progression of the disease. 1) There were no normal arterioles and venules phenotypically and morphologically observed in PWS skin; both arterioles and venules showed differentiation impairments, resulting in a reduction of arteriole-like vasculatures and defects in capillary loop formation in PWS lesions...
June 9, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28598555/experimental-and-numerical-investigation-on-the-transient-vascular-thermal-response-to-multi-pulse-nd-yag-laser
#12
Dong Li, Ruohui Li, Hao Jia, Bin Chen, Wenjuan Wu, Zhaoxia Ying
BACKGROUND AND OBJECTIVE: Port wine stains (PWS) are congenital vascular malformations that progressively darken and thicken with age. Laser therapy is currently the most effective way in clinical practice for PWS. A 1,064 nm Nd:YAG laser in the near-infrared band can achieve a deeper treatment depth compared to the current widely adopted pulsed dye laser. However, because of its relatively weak absorption by blood, single-pulse Nd:YAG laser requires high energy density to cause effective vessel damage, but may inflict undesirable burning to surrounding collagen...
June 9, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28584521/tranexamic-acid-encapsulating-thermosensitive-liposomes-for-site-specific-pharmaco-laser-therapy-of-port-wine-stains
#13
M Ingmar van Raath, Ruud Weijer, Gia Hung Nguyen, Bernard Choi, Anton I de Kroon, Michal Heger
Site-specific pharmaco-laser therapy (SSPLT) is a developmental stage treatment modality designed to non-invasively remove superficial vascular pathologies such as port wine stains (PWS) by combining conventional laser therapy with the prior administration of a prothrombotic and/or antifibrinolytic pharmaceutical-containing drug delivery system. For the antifibrinolytic SSPLT component, six different PEGylated thermosensitive liposomal formulations encapsulating tranexamic acid (TA), a potent antifibrinolytic lysine analogue, were characterized for drug:lipid ratio, encapsulation efficiency, size, endovesicular TA concentration (CTA), phase transition temperature (Tm), and assayed for heat-induced TA release...
August 2016: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/28578999/utility-and-tolerability-of-the-long-pulsed-1064-nm-neodymium-yttrium-aluminum-garnet-lp-nd-yag-laser-for-treatment-of-symptomatic-or-disfiguring-vascular-malformations-in-children-and-adolescents
#14
Aditi S Murthy, Annelise Dawson, Deepti Gupta, Shanna Spring, Kelly M Cordoro
BACKGROUND: Vascular malformations manifest with pain, bleeding, disability, and disfigurement in a subset of children. There are scant data available on the utility and tolerability of laser surgery for symptomatic or disfiguring non-port-wine stain vascular malformations in children. OBJECTIVE: The objective of this study was to determine the utility and tolerability of the 1064-nm long-pulsed neodymium:yttrium-aluminum-garnet (LP Nd:YAG) laser for treatment of symptomatic or disfiguring vascular malformations in children...
June 1, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28577186/multiple-laser-pulses-in-conjunction-with-an-optical-clearing-agent-to-improve-the-curative-effect-of-cutaneous-vascular-lesions
#15
Jun Ma, Bin Chen, Yue Zhang, Dong Li, Zhuang Lin Xing
Port-wine stains (PWSs) usually respond poorly to pulsed dye laser treatment because of the shallow penetration and light absorption of melanin in the epidermis. Multiple laser pulses (MLPs) Nd:YAG laser in conjunction with an optical clearing agent can help to reduce the total laser energy required for blood coagulation. The quantitative optical clearing effect (OCE) of glycerol was investigated by using a tissue-like phantom. Thereafter, an in vitro capillary tube experimental system and an in vivo hamster dorsal skin chamber experiment for the laser treatment of PWSs were established to visually obtain the quantitative relationship between the OCE and the blood coagulation properties under the irradiation of 1064 nm MLPs...
June 3, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28541265/optical-coherence-tomography-visualization-of-a-port-wine-stain-in-a-patient-with-sturge-weber-syndrome
#16
Adam S Aldahan, Lucy L Chen, John P Tsatalis, James M Grichnik
No abstract text is available yet for this article.
June 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28521517/dynamic-model-of-vascular-targeted-photodynamic-therapy
#17
Xiao-Ming Hu, Linhuan He, Yi Zhao
Vascular-targeted photodynamic therapy has shown efficiency in treating port wine stains. A dynamic model that incorporates blood flow, kinetic diffusion, oxygen and photosensitizer consumption and reaction, and light modulation is proposed to reveal the interactions among light, photosensitizer, and oxygen. Simulation results show that pulse light modulation synchronized with heartbeats hold the advantage of increased singlet oxygen accumulation, higher oxygen concentration and lower temperature. Meanwhile, constant light treatment is advantageous in terms of higher temperature, lower total oxygen concentration and singlet oxygen accumulation...
August 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/28504088/greater-detection-of-small-caliber-blood-vessels-in-port-wine-stain-with-x-mode-than-with-conventional-doppler-a-pilot-study
#18
I Salgüero Fernández, F Alfageme Roldán, G Roustan Gullón
No abstract text is available yet for this article.
May 12, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28489260/histologic-changes-associated-with-talaporfin-sodium-mediated-photodynamic-therapy-in-rat-skin
#19
Wesley J Moy, Jonathan Yao, Sébastien M de Feraudy, Sean M White, Jocelynda Salvador, Kristen M Kelly, Bernard Choi
BACKGROUND AND OBJECTIVE: Alternative treatments are needed to achieve consistent and more complete port wine stain (PWS) removal, especially in darker skin types; photodynamic therapy (PDT) is a promising alternative treatment. To this end, we previously reported on Talaporfin Sodium (TS)-mediated PDT. It is essential to understand treatment tissue effects to design a protocol that will achieve selective vascular injury without ulceration and scarring. The objective of this work is to assess skin changes associated with TS-mediated PDT with clinically relevant treatment parameters...
May 10, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28459499/potential-biological-targets-for-bioassay-development-in-drug-discovery-of-sturge-weber-syndrome
#20
REVIEW
Fatemeh Mohammadipanah, Fatemeh Salimi
Sturge-Weber Syndrome (SWS) is among the neurocutaneous diseases, which has several clinical manifestations of ocular (glaucoma), cutaneous (port-wine stain), neurological (seizures) and vascular problems. Molecular mechanisms of SWS pathogenesis are initiated by the somatic mutation in GNAQ. Therefore, no definite treatments exist for the SWS and treatment options only mitigate the intensity of its clinical manifestations. Biological assay design for drug discovery against this syndrome demands comprehensive knowledge on mechanisms which are involved in its pathogenesis...
April 29, 2017: Chemical Biology & Drug Design
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