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https://www.readbyqxmd.com/read/29782386/a-systematic-review-of-biodegradable-biliary-stents-promising-biocompatibility-without-stent-removal
#1
Antti Siiki, Juhani Sand, Johanna Laukkarinen
Biodegradable self-expanding stents are an emerging alternative to standard biliary stents as the development of endoscopic insertion devices advances. The aim was to systematically review the existing literature on biodegradable biliary stents. In-vivo studies on the use of biodegradable stents in the biliary duct were systematically reviewed from 1990 to 2017. Despite extensive research on the biocompatibility of stents, the experience so far on their clinical use is limited. A few favorable reports have recently been presented on endoscopically and percutaneously inserted self-expanding biodegradable polydioxanone stents in benign biliary strictures...
May 18, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29781738/diagnosis-of-cholangiocarcinoma-in-primary-sclerosing-cholangitis
#2
Seyed Alireza Taghavi, Ahad Eshraghian, Ramin Niknam, Gholam Reza Sivandzadeh, Kamran Bagheri Lankarani
Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease of the hepatobiliary system characterized by chronic inflammation, progressive fibrosis, stricture formation and destruction of extrahepatic and intrahepatic bile ducts. Areas covered: The increased incidence of cholangiocarcinoma (CCA) in PSC has been well documented and can be explained by the continuous inflammation in the biliary tree leading to an enhanced dysplasia-carcinoma sequence. Although PSC patients may progress to liver cirrhosis; CCA most commonly occurs between the ages of 30 and 45 years when cirrhosis has not yet developed...
May 21, 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29767392/a-novel-rabbit-model-for-benign-biliary-stricture-formation-and-the-effects-of-medication-infusions-on-stricture-formation
#3
Qin Yang, Junke Wang, Fei Liu, Wenjie Ma, Haijie Hu, Congdun Ran, Fuyu Li, Qiuwei Pan
BACKGROUND: Benign biliary stricture (BBS) is highly refractory. Currently, there is no effective strategy for prevention of BBS recurrence. The aim of this study is to establish a novel BBS rabbit model and to investigate the efficacy of biliary infusion with anti-proliferative medications for treating BBS. METHOD: A BBS model was established via surgical injury and biliary infection. The biliary infusion tube was inserted into the common bile duct via the stump of cystic duct after cholecystectomy...
May 16, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29767269/-igg4-associated-cholangitis-clinical-presentation-of-an-overlooked-disease-entity
#4
REVIEW
T Herta, J Verheij, U Beuers
IgG4-associated cholangitis (IAC) is the hepatobiliary manifestation of immunoglobulin G4-related disease, which is an immune-mediated fibroinflammatory systemic disorder characterised by often elevated IgG4 serum levels and typical histopathological findings in affected tissues. IAC is frequently (>90%) accompanied by autoimmune pancreatitis type 1 (AIP), which is the pancreatic manifestation of immunoglobulin G4-related disease. In 80-85% of the cases patients with IAC are male, above 50 years of age and present with jaundice and weight loss...
May 16, 2018: Der Internist
https://www.readbyqxmd.com/read/29753567/junctional-adhesion-molecules-jam-b-and-jam-c-promote-autoimmune-mediated-liver-fibrosis-in-mice
#5
Edith Hintermann, Monika Bayer, Clara Benedetta Conti, Sina Fuchs, Michel Fausther, Patrick S Leung, Michel Aurrand-Lions, Richard Taubert, Josef M Pfeilschifter, Mireen Friedrich-Rust, Detlef Schuppan, Jonathan A Dranoff, M Eric Gershwin, Michael P Manns, Beat A Imhof, Urs Christen
Fibrosis remains a serious health concern in patients with chronic liver disease. We recently reported that chemically induced chronic murine liver injury triggers increased expression of junctional adhesion molecules (JAMs) JAM-B and JAM-C by endothelial cells and de novo synthesis of JAM-C by hepatic stellate cells (HSCs). Here, we demonstrate that biopsies of patients suffering from primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) or autoimmune hepatitis (AIH) display elevated levels of JAM-C on portal fibroblasts (PFs), HSCs, endothelial cells and cholangiocytes, whereas smooth muscle cells expressed JAM-C constitutively...
May 9, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29749333/unexpected-outcome-following-radiofrequency-ablation-of-a-malignant-biliary-stricture
#6
Andrew J Kruger, Somashekar G Krishna
We present a case of a 60-year-old woman with extrahepatic cholangiocarcinoma and recurrent malignant biliary strictures status post placement of two overlapping distal bile duct uncovered self-expandable metal stents (SEMSs) who presented with biliary obstruction due to tumor/tissue ingrowth. She subsequently underwent radiofrequency ablation (RFA) through SEMS to improve biliary stent patency. Post-RFA, thermal injury was observed in the periampullary mucosa. She later developed acute pancreatitis. This is the first case of RFA-induced acute pancreatitis with endoscopic evidence of thermal injury...
March 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29741240/follow-up-magnetic-resonance-imaging-3d-magnetic-resonance-cholangiopancreatography-in-patients-with-primary-sclerosing-cholangitis-challenging-for-experts-to-interpret
#7
R Zenouzi, T Liwinski, J Yamamura, C Weiler-Normann, M Sebode, S Keller, A W Lohse, C Schramm
BACKGROUND: In patients with primary sclerosing cholangitis follow-up magnetic resonance imaging (MRI) with magnetic resonance cholangiopancreatography (MRCP) is performed by many centres, particularly for the early detection of biliary malignancies and strictures. Clinically meaningful MRI-based definitions of primary sclerosing cholangitis related complications are, however, lacking. AIM: To investigate how primary sclerosing cholangitis experts interpret follow-up MRI/MRCP with a focus on conclusions that may impact clinical decision-making in primary sclerosing cholangitis...
May 9, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29737419/langerhans-cell-histiocytosis-presenting-as-crohn-s-disease-a-case-report
#8
Amelie Therrien, Zaki El Haffaf, Claire Wartelle-Bladou, Justin Côté-Daigneault, Bich N Nguyen
PURPOSE: We describe an exceptional case of Langerhans cell histiocytosis (LCH) that presented as Crohn's disease and primary sclerosing cholangitis. METHODS: The patient's clinical, endoscopic, and histologic data from the Centre Hospitalier de l'Universite de Montreal were reviewed, as well as the literature on LCH involving the digestive tract and the liver, with a focus on the similarities with Crohn's disease and primary sclerosing cholangitis. RESULTS: A 39 years-old man first presented with anal fissures and deep punctiform colonic ulcers...
May 8, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29736970/preoperative-biliary-drainage-associated-with-biliary-stricture-after-pancreaticoduodenectomy-a-population-based-study
#9
Chien-Hui Wu, Te-Wei Ho, Jin-Ming Wu, Ting-Chun Kuo, Ching-Yao Yang, Fei-Pei Lai, Yu-Wen Tien
BACKGROUND: The rate of preoperative biliary drainage for pancreaticoduodenectomy has been increasing despite most recent evidence that favors avoiding it. Only a few studies have focused on late surgical complications - biliary stricture after pancreaticoduodenectomy and have produced only inconclusive results. We evaluate the role of preoperative biliary drainage in formation of biliary stricture after pancreaticoduodenectomy. METHODS: The Taiwan National Health Insurance Program is a mandatory health care plan covers nearly the entire population of 23-million in this country...
May 7, 2018: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/29736314/detection-of-early-stage-extrahepatic-cholangiocarcinoma-in-patients-with-biliary-strictures-by-soluble-b7-h4-in-the-bile
#10
Wenbo Ke, Li Zeng, Yunbi Hu, Sisi Chen, Min Tian, Qinggang Hu
Increasing evidence has demonstrated that serum soluble B7-H4 (sB7-H4) is a useful tumour marker for cancer diagnosis and prognosis evaluation. Whether sB7-H4 is expressed in the bile of cholangiocarcinoma (CC) and is related to the progression of CC need to be explored. Bile sB7-H4 was obtained through endoscopic retrograde cholangiopancreatography (ERCP) from 213 patients with biliary strictures and detected was detected by a B7-H4 ELISA kit. Diagnostic value was compared among bile sB7-H4, CA19-9, CA12-5, CEA and ERCP-based cytological/tissue examination...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29729226/eus-guided-hepaticoenterostomy-as-a-portal-to-allow-definitive-antegrade-treatment-of-benign-biliary-diseases-in-patients-with-surgically-altered-anatomy
#11
Theodore W James, Y Claire Fan, Todd H Baron
BACKGROUND & AIMS: EUS-guided hepaticoenterostomy (EUS-HE) is usually reserved for palliation of malignant biliary obstruction after failed endoscopic retrograde cholangiography (ERC) or inaccessible biliary tree in surgically altered anatomy (SAA). We describe outcome of EUS-HE and antegrade therapy for benign biliary disease in patients with SAA. METHODS: Retrospective review of 20 consecutive patients with surgically altered anatomy and benign biliary obstruction who underwent EUS-HE performed by one endoscopist at a tertiary center over a three-year period...
May 2, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29727803/synchronous-double-primary-cancers-of-the-extrahepatic-bile-duct-a-case-report-and-literature-review
#12
Takeshi Nishi, Yoshitoshi Sato, Takuya Hanaoka, Takuya Takahashi, Hiroshi Miura, Kenji Takubo
BACKGROUND: Double cancers of the biliary tract system are rare. Most of these cancers are synchronous double cancers of the gall bladder and bile duct, associated with pancreaticobiliary maljunction (PBM). Synchronous double cancers of the extrahepatic bile duct without PBM are especially rare, and only 4 cases have been reported. CASE PRESENTATION: A 78-year-old woman was admitted to our hospital for examination of hyperbilirubinemia and liver dysfunction. Contrast-enhanced abdominal computed tomography, Magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography revealed 2 stenotic regions in the common bile duct: at its junction with the cystic duct and in the distal bile duct...
April 27, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29724406/a-literature-based-cost-analysis-of-tissue-plasminogen-activator-for-prevention-of-biliary-stricture-in-donation-after-circulatory-death-liver-transplantation
#13
J M Jones, N Bhutiani, D Wei, L Goldstein, C M Jones, R M Cannon
INTRODUCTION: This study sought to approximate the cost-effectiveness of tPA utilization for prevention of biliary strictures (PTBS) in donation after circulatory death liver transplantation (DCD-LT). METHODS: Previously-reported PTBS rates in DCD-LT with and without tPA were used to calculate the number needed to treat (NNT) for prevention of one PTBS. The incremental cost of PTBS was then used to determine the cost effectiveness of tPA for prevention of PTBS. RESULTS: The incidence of PTBS in the setting of tPA administration was 20%, while incidence in patients without tPA use was 43% (p < 0...
April 17, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29713676/novel-temperature-controlled-rfa-probe-for-treatment-of-blocked-metal-biliary-stents-in-patients-with-pancreaticobiliary-cancers-initial-experience
#14
Manu K Nayar, Kofi W Oppong, Noor L H Bekkali, John S Leeds
Background and study aims:  Radiofrequency ablation (RFA) is used to treat blocked biliary stents in patients with pancreaticobiliary (PB) tumors with varying results. We report our experience with a novel temperature-controlled probe for treatment of blocked metal stents. Patients and methods:  Patients with histologically proven PB cancers and a blocked biliary stents were treated using ELRATM electrode (Taewoong Medical) under fluoroscopic guidance. Demographics, clinical outcome, stricture diameter improvements, complications and mortality at 30 days were prospectively recorded...
May 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29713573/percutaneous-management-of-biliary-enteric-anastomotic-strictures-an-institutional-review
#15
Muhammad Azeemuddin, Nauman Turab, Mustafa Belal H Chaudhry, Shoaib Hamid, Mohammad Hasan, Raza Sayani
Purpose Stricture formation at the biliary enteric anastomotic site is a common complication due to fibrotic healing. Few therapeutic options are available for biliary-enteric anastomotic site stricture (BES) including new surgical reconstruction or percutaneous transhepatic biliary drainage followed by balloon dilation of BES or stent placement. The purpose of this study is to assess the technical success, complications and reintervention rate of percutaneous transhepatic balloon dilatation (PTBD) of BES after iatrogenic bile duct injuries (BDI)...
February 26, 2018: Curēus
https://www.readbyqxmd.com/read/29712892/sequencing-of-intraductal-biopsies-is-feasible-and-potentially-impacts-clinical-management-of-patients-with-indeterminate-biliary-stricture-and-cholangiocarcinoma
#16
Katrin Bankov, Claudia Döring, Markus Schneider, Sylvia Hartmann, Ria Winkelmann, Joerg G Albert, Wolf Otto Bechstein, Stefan Zeuzem, Martin Leo Hansmann, Jan Peveling-Oberhag, Dirk Walter
BACKGROUND: Definite diagnosis and therapeutic management of cholangiocarcinoma (CCA) remains a challenge. The aim of the current study was to investigate feasibility and potential impact on clinical management of targeted sequencing of intraductal biopsies. METHODS: Intraductal biopsies with suspicious findings from 16 patients with CCA in later clinical course were analyzed with targeted sequencing including tumor and control benign tissue (n = 55 samples)...
April 30, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29712886/outcomes-of-adult-liver-transplantation-from-donation-after-brain-death-followed-by-circulatory-death-in-china
#17
Jiabin Zhang, Hui Ren, Yanling Sun, Zhijie Li, Hongbo Wang, Zhenwen Liu, Shaotang Zhou
BACKGROUND Organ donation from a deceased donor, which is donation after brain death followed by circulatory death, is a unique transplantation practice in China. Pathological features of grafts help guide the utilization of grafts. MATERIAL AND METHODS We retrospectively reviewed our experiences in 188 DBCD allografts from May 2014 to April 2017. We divided 183 transplanted allografts into 3 groups according to pretransplant histology: the good quality graft group (n=62), the preservation injury group (n=27), and the steatotic graft group (n=94)...
May 1, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29685633/late-benign-biliary-complications-after-pancreatoduodenectomy
#18
Takaaki Ito, Teiichi Sugiura, Yukiyasu Okamura, Yusuke Yamamoto, Ryo Ashida, Takeshi Aramaki, Masahiro Endo, Hiroyuki Matsubayashi, Hirotoshi Ishiwatari, Katsuhiko Uesaka
BACKGROUND: Pancreatoduodenectomy sometimes causes late benign biliary complications, such as biliary stricture and/or hepaticolithiasis, which require intervention. The risk factors and timing of late biliary complications remain unclear. The purpose of this study was to clarify the incidence, timing of occurrence, and risk factors for late biliary complications after pancreatoduodenectomy. METHODS: A total of 732 patients who underwent pancreatoduodenectomy between 2002 and 2016 were included in this retrospective study...
April 20, 2018: Surgery
https://www.readbyqxmd.com/read/29675964/antegrade-tissue-scraping-through-eus-guided-hepaticogastrostomy-with-video
#19
Takeshi Ogura, Atsushi Okuda, Kazuhide Higuchi
A novel endoscopic device (Fig 1a, Trefle, Piolax Medical Devices, Yokohama, Japan) for collecting sufficient amounts of biliary tract tissue samples under ERCP guidance for pathological diagnosis is now available in Japan [1]. Because of easy accessibility into the biliary tract through the bile duct stricture, this device might be clinically useful via a transluminal approach. Here, we described technical tips for collecting bile-duct tissue samples under EUS-guided antegrade access. A 78-year-old man who had undergone distal gastrectomy with Roux-en-Y gastrojejunostomy to treat a gastric ulcer was referred to our hospital with obstructive jaundice...
April 19, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29672294/endoscopic-ultrasound-guided-choledocho-enterostomy-by-using-lumen-apposing-metal-stent-in-patients-with-failed-endoscopic-retrograde-cholangiopancreatography-a-literature-review
#20
Deepanshu Jain, Manan Shah, Upen Patel, Abhinav Sharma, Shashideep Singhal
BACKGROUND: Endoscopic retrograde cholangiopancreatography (ERCP) has been the cornerstone in the management of malignant jaundice to provide symptomatic relief and/or to allow chemotherapy. Difficult biliary cannulation or the presence of concomitant duodenal obstruction may lead to its failure. METHOD: An extensive English literature search was done via PubMed and Google Scholar to identify 13 peer-reviewed original articles. RESULTS: Of 92 patients, 98...
April 19, 2018: Digestion
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