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Biliary stricture

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https://www.readbyqxmd.com/read/28098776/distinguishing-benign-from-malignant-pancreatic-and-periampullary-lesions-using-combined-use-of-%C3%A2-h-nmr-spectroscopy-and-gas-chromatography-mass-spectrometry
#1
Yarrow J McConnell, Farshad Farshidfar, Aalim M Weljie, Karen A Kopciuk, Elijah Dixon, Chad G Ball, Francis R Sutherland, Hans J Vogel, Oliver F Bathe
Previous work demonstrated that serum metabolomics can distinguish pancreatic cancer from benign disease. However, in the clinic, non-pancreatic periampullary cancers are difficult to distinguish from pancreatic cancer. Therefore, to test the clinical utility of this technology, we determined whether any pancreatic and periampullary adenocarcinoma could be distinguished from benign masses and biliary strictures. Sera from 157 patients with malignant and benign pancreatic and periampullary lesions were analyzed using proton nuclear magnetic resonance (¹H-NMR) spectroscopy and gas chromatography-mass spectrometry (GC-MS)...
January 13, 2017: Metabolites
https://www.readbyqxmd.com/read/28081547/diagnosis-of-pancreaticobiliary-malignancy-by-detection-of-minichromosome-maintenance-protein-5-in-biliary-brush-cytology
#2
Margaret G Keane, Matthew T Huggett, Michael H Chapman, Gavin J Johnson, George J Webster, Douglas Thorburn, James Mackay, Stephen P Pereira
BACKGROUND: Biliary brush cytology is the standard method of evaluating biliary strictures, but is insensitive at detecting malignancy. In pancreaticobiliary cancer minichromosome maintenance replication proteins (MCM 2-7) are dysregulated in the biliary epithelium and MCM5 levels are elevated in bile samples. This study aimed to validate an immunocolorimetric ELISA assay for MCM5 as a pancreaticobiliary cancer biomarker in biliary brush samples. METHODS: Biliary brush specimens were collected prospectively at ERCP from patients with a biliary stricture...
January 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28076371/meta-analysis-of-the-long-term-success-rate-of-different-interventions-in-benign-biliary-strictures
#3
Orsolya Huszár, Bálint Kokas, Péter Mátrai, Péter Hegyi, Erika Pétervári, Áron Vincze, Gabriella Pár, Patrícia Sarlós, Judit Bajor, József Czimmer, Dóra Mosztbacher, Katalin Márta, Csaba Zsiborás, Péter Varjú, Ákos Szücs
BACKGROUND: Benign biliary stricture is a rare condition and the majority of the cases are caused by operative trauma or chronic inflammation based on various etiology. Although the initial results of endoscopic, percutaneous and surgical treatment are impressive, no comparison about long term stricture resolution is available. AIMS: The goal of this study was to compare the long term disease free survival in benign biliary strictures with various etiology after surgery, percutaneous transhepatic-and endoscopic treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28042247/a-fully-covered-self-expandable-metal-stent-anchored-by-a-10-fr-double-pigtail-plastic-stent-an-effective-anti-migration-technique
#4
Panagiotis Katsinelos, Georgia Lazaraki, Stergios Gkagkalis, Grigoris Chatzimavroudis, Kiriaki Anastasiadou, Nikos Georgakis, Olga Giouleme, Christos Zavos, Jannis Kountouras
BACKGROUND: Fully covered self-expandable metal stents (FCSEMS) have been used successfully in the treatment of malignant and benign biliary strictures. However, stent migration is a major complication. We investigated the efficacy of anchoring FCSEMS with a 10-Fr double-pigtail plastic stent to prevent migration in patients with biliary strictures. METHODS: Between January 2012 and May 2013, 10 patients with malignant biliary strictures and one patient with a suprapapillary benign biliary stenosis were enrolled in the study...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/28032654/novel-characteristics-of-traction-force-in-biliary-self-expandable-metallic-stents
#5
Yasuki Hori, Kazuki Hayashi, Michihiro Yoshida, Itaru Naitoh, Tesshin Ban, Katsuyuki Miyabe, Hiromu Kondo, Yuji Nishi, Shuichiro Umemura, Yasuaki Fujita, Makoto Natsume, Akihisa Kato, Hirotaka Ohara, Takashi Joh
OBJECTIVES: In recent years, knowledge concerning the mechanical properties of self-expandable metallic stents (SEMS) has increased. In a previous study, we defined traction force and traction momentum and reported that these characteristics are important for optimal stent deployment. However, traction force and traction momentum were represented as relative values and were not evaluated in various conditions. The purpose of this study was to measure traction force in various situations assumed during SEMS placement...
December 29, 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28030370/the-evolution-of-natural-history-of-primary-sclerosing-cholangitis
#6
Will R Takakura, James H Tabibian, Christopher L Bowlus
PURPOSE OF REVIEW: Primary sclerosing cholangitis (PSC) is a rare, idiopathic biliary disease often with an insidious onset, variable disease course, and premature death related to benign and malignant PSC-related sequelae. This review aims to discuss the epidemiology, clinical variants, and natural history of PSC, incorporating data from recent population-based studies. RECENT FINDINGS: PSC naturally leads to cirrhosis, cholangiocarcinoma, other hepatobiliary malignancies, dominant strictures, hepatic osteodystrophy, and bacterial cholangitis...
December 24, 2016: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28018098/therapeutic-approaches-for-portal-biliopathy-a-systematic-review
#7
REVIEW
Irene Franceschet, Alberto Zanetto, Alberto Ferrarese, Patrizia Burra, Marco Senzolo
Portal biliopathy (PB) is defined as the presence of biliary abnormalities in patients with non-cirrhotic/non-neoplastic extrahepatic portal vein obstruction (EHPVO) and portal cavernoma (PC). The pathogenesis of PB is due to ab extrinseco compression of bile ducts by PC and/or to ischemic damage secondary to an altered biliary vascularization in EHPVO and PC. Although asymptomatic biliary abnormalities can be frequently seen by magnetic resonance cholangiopancreatography in patients with PC (77%-100%), only a part of these (5%-38%) are symptomatic...
December 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28017843/mutation-profile-and-fluorescence-in-situ-hybridization-analyses-increase-detection-of-malignancies-in-biliary-strictures
#8
Tamas A Gonda, Domenico Viterbo, Valerie Gausman, Claudine Kipp, Amrita Sethi, John M Poneros, Frank Gress, Tina Park, Ali Khan, Sara A Jackson, Megan Blauvelt, Nicole Toney, Sydney D Finkelstein
BACKGROUND & AIMS: It is a challenge to detect malignancies in biliary strictures. Various sampling methods are available to increase diagnostic yield, but these require additional procedure time and expertise. We evaluated the combined accuracy of fluorescence in situ hybridization (FISH) and PCR-based DNA mutation profiling (MP) of specimens collected using standard brush techniques. METHODS: We performed a prospective study of 107 consecutive patients treated for biliary strictures by endoscopic retrograde cholangiopancreatography from June 2012 through June 2014...
December 22, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27997964/treatment-of-biliary-strictures-with-fully-covered-self-expandable-metal-stents-after-pancreaticoduodenectomy
#9
Hitoshi Shibuya, Kazuo Hara, Nobumasa Mizuno, Susumu Hijioka, Hiroshi Imaoka, Masahiro Tajika, Tsutomu Tanaka, Makoto Ishihara, Yutaka Hirayama, Tsukasa Yoshida, Nozomi Okuno, Nobuhiro Hieda, Patommatat Bhanthumkomol, Yasuhiro Shimizu, Yoshiki Senda, Seiji Natsume, Yasumasa Niwa, Kenji Yamao
Background and study aims Anastomotic stricture is a late complication after biliary reconstructive surgery, but standard treatments are currently lacking. We selected patients who had undergone pancreaticoduodenectomy and Child's procedure, and aimed to evaluate the safety and efficacy of temporary placement of fully covered self-expandable metal stents (FCSEMSs) to treat postoperative anastomotic stricture. Patients and methods This study retrospectively analyzed 13 patients who underwent treatment with FCSEMSs for anastomotic stricture between June 2011 and March 2016...
January 2017: Endoscopy
https://www.readbyqxmd.com/read/27994331/primary-closure-following-laparoscopic-common-bile-duct-reexploration-for-the-patients-who-underwent-prior-biliary-operation
#10
Kai Zhang, Feng Zhan, Yun Zhang, Chao Jiang, Miao Zhang, Xiaotian Yu, Tieliang Ma, Haorong Wu
To assess feasibility of primary closure following laparoscopic common bile duct reexploration for the patients who underwent prior biliary operation, we retrospectively studied 50 patients with recurrent or residual common bile duct (CBD) stones who underwent laparoscopic biliary reoperation between June 2008 and June 2013. Endoscopic sphincterotomy (EST) was treated for all these patients and validated failed. They were divided into two groups. Primary closure following laparoscopic common bile duct exploration (LCBDE) was performed in 25 cases (group A); LCBDE plus T-tube drainage was performed in others (group B)...
October 2016: Indian Journal of Surgery
https://www.readbyqxmd.com/read/27989363/complications-in-pediatric-hepatobiliary-surgery
#11
Gabriella Grisotti, Robert A Cowles
This review highlights the complications and their risk factors encountered in pediatric hepatobiliary surgery, specifically in the context of pediatric hepatic resection, excision of choledochal cyst, and the Kasai hepatoportoenterostomy procedure for biliary atresia as well as other procedures potentially affecting the biliary tree. With the understanding that these are relatively rare procedures, case reports and small case series are included in addition to larger series when available. The review focuses on publications in English over the past 15 years...
December 2016: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/27981308/primary-biliary-cirrhosis-and-primary-sclerosing-cholangitis-an-update-on-mr-imaging-findings-with-recent-developments
#12
REVIEW
Jelena Djokić Kovač, Marc-André Weber
Primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC) are the most common immune-mediated chronic cholestatic liver diseases leading to cirrhosis and liver failure. Although magnetic resonance imaging (MRI) is not a necessary procedure for the diagnosis of PBC, MRI is recommended for monitoring disease progression and early detection of complications. Even though liver cirrhosis subtypes have similar MR imaging features, there are some findings which could indicate PBC, such as the periportal halo sign...
December 2016: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/27943017/carcinoembryonic-antigen-level-in-primary-sclerosing-cholangitis-is-not-influenced-by-dominant-strictures-or-bacterial-cholangitis
#13
Andreas Wannhoff, Christian Rupp, Kilian Friedrich, Johannes Knierim, Christa Flechtenmacher, Karl Heinz Weiss, Wolfgang Stremmel, Daniel N Gotthardt
BACKGROUND: Carcinoembryonic antigen (CEA) can be used to screen for biliary tract cancer in patients with primary sclerosing cholangitis (PSC). AIM: To study the influence of benign dominant strictures (DS), superimposed bacterial cholangitis (SBC), smoking status, and inflammatory bowel disease on CEA serum levels. METHODS: A retrospective analysis of CEA values in cancer-free PSC patients was performed. We included the maximal CEA value obtained during follow-up and information on the presence of DS and SBC at that time, and we analyzed the CEA values in the presence and absence of DS and SBC...
December 9, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27941438/low-measured-hepatic-artery-flow-increases-rate-of-biliary-strictures-in-deceased-donor-liver-transplantation-an-age-dependent-phenomenon
#14
P T W Kim, H Fernandez, A Gupta, G Saracino, M Ramsay, G J McKenna, G Testa, T L Anthony, N Onaca, R M Ruiz, G B Klintmalm
BACKGROUND: This study was conducted to determine effect of lower measured hepatic arterial (HA) flow (<400 mL/min) on biliary complications and graft survival after deceased donor liver transplantation. Hepatic artery is the main blood supply to bile duct and lack of adequate HA flow is thought to be a risk factor for biliary complications. METHODS: A retrospective review of 1300 patients who underwent deceased donor liver transplantation was performed. Patients with arterial complications were excluded to eliminate potential contribution to biliary complications from HA thrombosis...
December 8, 2016: Transplantation
https://www.readbyqxmd.com/read/27932131/t-tube-systematic-use-in-the-biliary-anastomosis-comparison-of-two-consecutive-series-of-liver-transplantation
#15
C M García Bernardo, I González-Pinto Arrillaga, A Miyar de León, V Cadahia Rodrigo, L González Dieguez, L Barneo Serra, L Vázquez Velasco
OBJECTIVES: The authors sought to check the frequency of biliary complications with the use of a T-tube. In 2012, throughout the year, it was carried out systematically in all liver transplantations regardless of the characteristics of the bile duct. Despite the long experience, biliary complications remain a common cause of postoperative morbidity and mortality. MATERIAL AND METHODS: In this study we compared complications in 23 consecutive transplantation cases using T-tube biliary anastomosis during the year 2012 with 23 consecutive transplantation cases without T-tube during the year 2013...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27931575/bile-duct-anastomosis-supplied-with-biodegradable-stent-in-liver-transplantation-the-initial-experience
#16
L Janousek, S Maly, M Oliverius, M Kocik, M Kucera, J Fronek
BACKGROUND: The most common biliary complications after orthotopic liver transplantation are bile leaks, anastomotic and intrahepatic strictures, stones, and ampullary dysfunction. These complications can occur in up to 10% to 30% of liver transplant recipients. Leaks occur early in the posttransplant period; the stricture formation typically graduates over time. METHODS: Ten patients underwent transplantation in our preliminary study: 5 were randomized to the group with stent placement and 5 to the control group...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27925689/prognostic-significance-of-hepatic-arterial-collaterals-in-liver-transplant-recipients-with-biliary-strictures
#17
André Viveiros, Rafael Rehwald, Erich Vettori, Armin Finkenstedt, Maria Effenberger, Benedikt Schaefer, Livia Dorn, Herbert Tilg, Stefan Schneeberger, Bernhard Glodny, Heinz Zoller, Martin C Freund
BACKGROUND: The aim of the present study was to determine the prevalence of hepatic artery stenosis (HAS) and the prognostic implications of hepatic arterial collaterals in liver transplant (LT) recipients with biliary strictures. METHODS: 105 LT recipients transplanted between 2004 and 2015 at our center had documented biliary strictures. HAS and collaterals were assessed in high quality imaging of the hepatic artery available from 66 recipients. Clinical, demographic and biochemical recipient and donor data were retrospectively analyzed and tested for their association with biliary of arterial complications after LT...
December 7, 2016: Clinical Transplantation
https://www.readbyqxmd.com/read/27922545/risk-factors-for-diabetes-mellitus-in-chronic-pancreatitis-a-cohort-of-2011-patients
#18
Jun Pan, Lei Xin, Dan Wang, Zhuan Liao, Jin-Huan Lin, Bai-Rong Li, Ting-Ting Du, Bo Ye, Wen-Bin Zou, Hui Chen, Jun-Tao Ji, Zhao-Hong Zheng, Liang-Hao Hu, Zhao-Shen Li
Diabetes mellitus (DM) is a common complication of chronic pancreatitis (CP) and increases the mortality. The identification of risk factors for DM development may contribute to the early detection and potential risk reduction of DM in patients with CP.Patients with CP admitted to Changhai Hospital (Shanghai, China) from January 2000 to December 2013 were enrolled. Cumulative rates of DM after the onset of CP were calculated by Kaplan-Meier method. Risk factors for DM development after the diagnosis of CP were identified by Cox proportional hazards regression model...
April 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27921193/an-isoperistaltic-jejunum-later-cut-overlap-method-for-esophagojejunostomy-anastomosis-after-totally-laparoscopic-total-gastrectomy-a-safe-and-feasible-technique
#19
Chang-Ming Huang, Ze-Ning Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu
BACKGROUND: Intracorporeal anastomosis after totally laparoscopic total gastrectomy (TLTG) has been increasingly applied. (1-7) We assessed the intracorporeal isoperistaltic jejunum-later-cut overlap method (IJOM) for esophagojejunostomy anastomosis (EA). METHODS: From January to June 2014, a total of 19 patients with resectable gastric cancer (cT1-T4aNOM0) underwent TLTG. IJOM was performed by creating side-to-side stapled anastomosis through enterotomies proximal to the left esophageal resection margin and on the antimesenteric jejunal border, 30 cm distal to the Trietz ligament...
December 5, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27914884/clinical-presentation-diagnosis-and-survival-in-cholangiocarcinoma-a-prospective-study
#20
Larisa Vasilieva, Stefanos I Papadhimitriou, Alexandra Alexopoulou, Ioannis Kostopoulos, Konstantinos Papiris, Dimitrios Pavlidis, Dimitrios Xinopoulos, Andreas Romanos, Spyridon P Dourakis
BACKGROUND AND STUDY AIMS: The diagnosis of cholangiocarcinoma (CCA) is difficult. The present study aimed to assess the clinical features, diagnosis, and survival in CCA. PATIENTS AND METHODS: This is a prospective study on 46 patients with CCA who underwent endoscopic retrograde cholangiopancreatography (ERCP) or surgical resection and 20 controls with a clinical and ERCP suspicion for CCA in whom surgical biopsy and/or 4-year follow-up showed a benign biliary stricture...
December 2016: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
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