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miR-506 acts as a tumor suppressor by directly targeting the hedgehog pathway transcription factor Gli3 in human cervical cancer.

S-Y Wen, Y Lin, Y-Q Yu, S-J Cao, R Zhang, X-M Yang, J Li, Y-L Zhang, Y-H Wang, M-Z Ma, W-W Sun, X-L Lou, J-H Wang, Y-C Teng, Z-G Zhang
Although significant advances have recently been made in the diagnosis and treatment of cervical carcinoma, the long-term survival rate for advanced cervical cancer remains low. Therefore, an urgent need exists to both uncover the molecular mechanisms and identify potential therapeutic targets for the treatment of cervical cancer. MicroRNAs (miRNAs) have important roles in cancer progression and could be used as either potential therapeutic agents or targets. miR-506 is a component of an X chromosome-linked miRNA cluster...
February 5, 2015: Oncogene
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