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Hepatocellular carcinoma, li-rads

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https://www.readbyqxmd.com/read/29230525/diagnostic-accuracy-of-prospective-application-of-the-liver-imaging-reporting-and-data-system-li-rads-in-gadoxetate-enhanced-mri
#1
Yeun-Yoon Kim, Chansik An, Sungwon Kim, Myeong-Jin Kim
OBJECTIVES: To evaluate the diagnostic performance of the LI-RADS (v2014) on gadoxetate-enhanced MRI prospectively applied in actual practice. METHODS: We retrospectively reviewed the prospectively written radiology reports of 143 treatment-naïve at-risk patients who underwent gadoxetate-enhanced liver MRI from January to December 2014, and identified 202 hepatic observations categorized using the LI-RADS. The diagnostic performances of LI-RADS categories for hepatocellular carcinoma (HCC) and hepatic malignancy were calculated...
December 11, 2017: European Radiology
https://www.readbyqxmd.com/read/29218367/cirrhosis-and-li-rads
#2
Demetrios Papadatos, Kathryn J Fowler, Ania Z Kielar, Jennifer Cui, Claude B Sirlin
Chronic liver disease, irrespective of cause, can eventually lead to cirrhosis, which is the primary risk factor for developing hepatocellular carcinoma (HCC). In patients with cirrhosis or appropriate risk factors, HCC can be diagnosed by imaging with high specificity using liver imaging reporting and data system v2017, obviating the need for histologic confirmation. Confident recognition of cirrhosis by conventional imaging alone can be challenging, as radiologists are not always provided with the requisite information to determine if the patient has cirrhosis or other risk factors for HCC...
December 7, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29209739/hepatocarcinogenesis-and-li-rads
#3
Kazim H Narsinh, Jennifer Cui, Demetri Papadatos, Claude B Sirlin, Cynthia S Santillan
Hepatocarcinogenesis is a multi-step process characterized by progressive cellular and molecular dedifferentiation of hepatocytes and culminating in the emergence of hepatocellular carcinoma (HCC). Knowledge of hepatocarcinogenesis is important because familiarity with the associated imaging features can lead to improved diagnosis of HCC at its early stages. The article reviews the alterations that accumulate leading to HCC result in abnormal imaging features, many of which are included in LI-RADS v2017 as major and ancillary features...
December 5, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29166245/evidence-supporting-li-rads-major-features-for-ct-and-mr-imaging-based-diagnosis-of-hepatocellular-carcinoma-a-systematic-review
#4
An Tang, Mustafa R Bashir, Michael T Corwin, Irene Cruite, Christoph F Dietrich, Richard K G Do, Eric C Ehman, Kathryn J Fowler, Hero K Hussain, Reena C Jha, Adib R Karam, Adrija Mamidipalli, Robert M Marks, Donald G Mitchell, Tara A Morgan, Michael A Ohliger, Amol Shah, Kim-Nhien Vu, Claude B Sirlin
The Liver Imaging Reporting and Data System (LI-RADS) standardizes the interpretation, reporting, and data collection for imaging examinations in patients at risk for hepatocellular carcinoma (HCC). It assigns category codes reflecting relative probability of HCC to imaging-detected liver observations based on major and ancillary imaging features. LI-RADS also includes imaging features suggesting malignancy other than HCC. Supported and endorsed by the American College of Radiology (ACR), the system has been developed by a committee of radiologists, hepatologists, pathologists, surgeons, lexicon experts, and ACR staff, with input from the American Association for the Study of Liver Diseases and the Organ Procurement Transplantation Network/United Network for Organ Sharing...
November 21, 2017: Radiology
https://www.readbyqxmd.com/read/29134355/extracellular-contrast-agent-enhanced-mri-15-min-delayed-phase-may-improve-the-diagnostic-performance-for-hepatocellular-carcinoma-in-patients-with-chronic-liver-disease
#5
Si Eun Lee, Chansik An, Shin Hye Hwang, Jin-Young Choi, Kyunghwa Han, Myeong-Jin Kim
OBJECTIVES: To determine the value of a 15-min delayed phase in extracellular contrast agent (ECA)-enhanced magnetic resonance imaging (MRI) for evaluation of hepatocellular carcinoma (HCC) in patients with chronic liver disease. METHODS: Between 2014 and 2015, 103 patients with chronic liver disease underwent ECA-enhanced MRI; 133 lesions consisting of 107 HCCs, 23 benign lesions and three non-HCC malignancies were identified with pathological or clinical diagnosis...
November 13, 2017: European Radiology
https://www.readbyqxmd.com/read/29133247/contrast-enhanced-ultrasound-identifies-hepatocellular-carcinoma-in-cirrhosis-a-large-multicenter-retrospective-study
#6
Eleonora Terzi, Massimo Iavarone, Maurizio Pompili, Letizia Veronese, Giuseppe Cabibbo, Mirella Fraquelli, Laura Riccardi, Ludovico De Bonis, Angelo Sangiovanni, Simona Leoni, Maria Assunta Zocco, Sandro Rossi, Nicola Alessi, Stephanie R Wilson, Fabio Piscaglia, Alessandro Granito, Veronica Salvatore, Francesco Tovoli, Matteo Angelo Manini, Gian Lodovico Rapaccini, Maria Elena Ainora, Valentina Ravetta, Giorgia Ghittoni, Agostino Ventra, Giuseppe Mogavero
BACKGROUND & AIMS: The use of contrast enhanced ultrasound (CEUS) for the diagnosis of hepatocellular carcinoma (HCC) in cirrhosis was questioned for the risk of false positive diagnosis in case of cholangiocarcinoma. The American College of Radiology has recently released a scheme (CEUS LI-RADS) classifying lesions at risk for HCC investigated by CEUS. Aim of the present study was to validate this LI-RADS scheme for the diagnosis of HCC. METHODS: A total of 1006 nodules in 848 patients with chronic liver disease at risk for HCC collected in 5 Italian centers were retrospectively analyzed...
November 10, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29131761/2017-version-of-li-rads-for-ct-and-mr-imaging-an-update
#7
Khaled M Elsayes, Jonathan C Hooker, Michelle M Agrons, Ania Z Kielar, An Tang, Kathryn J Fowler, Victoria Chernyak, Mustafa R Bashir, Yuko Kono, Richard K Do, Donald G Mitchell, Aya Kamaya, Elizabeth M Hecht, Claude B Sirlin
The Liver Imaging Reporting and Data System (LI-RADS) is a reporting system created for the standardized interpretation of liver imaging findings in patients who are at risk for hepatocellular carcinoma (HCC). This system was developed with the cooperative and ongoing efforts of an American College of Radiology-supported committee of diagnostic radiologists with expertise in liver imaging and valuable input from hepatobiliary surgeons, hepatologists, hepatopathologists, and interventional radiologists. In this article, the 2017 version of LI-RADS for computed tomography and magnetic resonance imaging is reviewed...
November 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29091751/interreader-reliability-of-li-rads-version-2014-algorithm-and-imaging-features-for-diagnosis-of-hepatocellular-carcinoma-a-large-international-multireader-study
#8
Kathryn J Fowler, An Tang, Cynthia Santillan, Mythreyi Bhargavan-Chatfield, Jay Heiken, Reena C Jha, Jeffrey Weinreb, Hero Hussain, Donald G Mitchell, Mustafa R Bashir, Eduardo A C Costa, Guilherme M Cunha, Laura Coombs, Tanya Wolfson, Anthony C Gamst, Giuseppe Brancatelli, Benjamin Yeh, Claude B Sirlin
Purpose To determine in a large multicenter multireader setting the interreader reliability of Liver Imaging Reporting and Data System (LI-RADS) version 2014 categories, the major imaging features seen with computed tomography (CT) and magnetic resonance (MR) imaging, and the potential effect of reader demographics on agreement with a preselected nonconsecutive image set. Materials and Methods Institutional review board approval was obtained, and patient consent was waived for this retrospective study. Ten image sets, comprising 38-40 unique studies (equal number of CT and MR imaging studies, uniformly distributed LI-RADS categories), were randomly allocated to readers...
January 2018: Radiology
https://www.readbyqxmd.com/read/29084013/ring-like-enhancement-of-hepatocellular-carcinoma-in-gadoxetic-acid-enhanced-multiphasic-hepatic-arterial-phase-imaging-with-differential-subsampling-with-cartesian-ordering
#9
Shintaro Ichikawa, Utaroh Motosugi, Naoki Oishi, Tatsuya Shimizu, Tetsuya Wakayama, Nobuyuki Enomoto, Masanori Matsuda, Hiroshi Onishi
OBJECTIVE: The aim of this study was to evaluate the efficacy of multiphasic hepatic arterial phase (HAP) imaging using DISCO (differential subsampling with Cartesian ordering) in increasing the confidence of diagnosis of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: This retrospective study was approved by the institutional review board, and the requirement for informed patient consent was waived. Consecutive patients (from 2 study periods) with malignant liver nodules were examined by gadoxetic acid-enhanced magnetic resonance imaging using either multiphasic (6 phases; n = 135) or single (n = 230) HAP imaging, which revealed 519 liver nodules other than benign ones (HCC, 497; cholangiocarcinoma, 11; metastases, 10; and malignant lymphoma, 1)...
October 27, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/29038857/li-rads-categories-concepts-definitions-and-criteria
#10
Cynthia Santillan, Victoria Chernyak, Claude Sirlin
The Liver Imaging Reporting and Data System (LI-RADS) was created to provide a standardized way to both assess and communicate the likelihood of benignity or malignancy of observations seen in patients at risk for development of hepatocellular carcinoma (HCC). The LI-RADS categories allow radiologists to convey the full spectrum of concern for malignancy, from definitely benign to definitely HCC. Additional categories are available for non-categorizable observations, observations that are concerning for a non-HCC malignancy, and the presence of tumor in vein...
October 16, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29023148/nonstandardized-terminology-to-describe-focal-liver-lesions-in-patients-at-risk-for-hepatocellular-carcinoma-implications-regarding-clinical-communication
#11
Michael T Corwin, Andrew Y Lee, Ghaneh Fananapazir, Thomas W Loehfelm, Souvik Sarkar, Claude B Sirlin
OBJECTIVE: The purpose of this study is to determine the correlation between malignancy risk of focal liver observations in patients at risk for hepatocellular carcinoma (HCC) implied by phrases used in nonstructured radiology reports with the risk inferred by hepatologists. MATERIALS AND METHODS: We performed a retrospective review of nonstructured radiology reports issued before Liver Imaging and Reporting Data System (LI-RADS) adoption from four-phase liver CT examinations of patients at risk for HCC...
October 12, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29018942/evaluation-of-an-abbreviated-screening-mri-protocol-for-patients-at-risk-for-hepatocellular-carcinoma
#12
Jennifer Y Lee, Eugene J Huo, Stefanie Weinstein, Charmaine Santos, Alexander Monto, Carlos U Corvera, Judy Yee, Thomas A Hope
PURPOSE: In this study, we compare an abbreviated screening MRI protocol (aMRI), utilizing only dynamic contrast-enhanced images, to a conventional liver MRI (cMRI) for the characterization of observations in at-risk patients. MATERIALS AND METHODS: 164 consecutive HCC screening MRIs were retrospectively analyzed. Two sets of de-identified image sets were created: one with all acquired sequences including T2- and diffusion-weighted sequences (cMRI), and one with only T1-weighted precontrast and dynamic post-contrast images utilizing an extracellular gadolinium contrast agent (aMRI)...
October 10, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28991560/screening-and-surveillance-of-hepatocellular-carcinoma-an-introduction-to-ultrasound-liver-imaging-reporting-and-data-system
#13
REVIEW
David T Fetzer, Shuchi K Rodgers, Alison C Harris, Yuko Kono, Ashish P Wasnik, Aya Kamaya, Claude Sirlin
Given the high prevalence, increasing incidence, and significant morbidity and mortality related to hepatocellular carcinoma (HCC), a robust and cost-effective screening and surveillance program is needed. Most societies recommend ultrasound for HCC screening, despite lack of standardization in imaging acquisition, reporting content and language, and follow-up recommendations. The American College of Radiology Ultrasound Liver Imaging Reporting and Data System (US LI-RADS) fills this unmet need by providing standardization in the use of US in at-risk patients...
November 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/28936543/us-li-rads-ultrasound-liver-imaging-reporting-and-data-system-for-screening-and-surveillance-of-hepatocellular-carcinoma
#14
Tara A Morgan, Katherine E Maturen, Nirvikar Dahiya, Maryellen R M Sun, Aya Kamaya
Ultrasound is the most widely used imaging tool for hepatocellular carcinoma (HCC) screening and surveillance. Until now, this method has lacked standardized guidelines for interpretation, reporting, and management recommendations [1-5]. To address this need, the American College of Radiology (ACR) has developed the Ultrasound Liver Imaging Reporting and Data System (US LI-RADS) algorithm. The proposed algorithm has two components: detection scores and visualization scores. The detection score guides management and has three categories: US-1 Negative, US-2 Subthreshold, and US-3 Positive...
September 21, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28914714/radiologically-undetected-hepatocellular-carcinoma-in-patients-undergoing-liver-transplantation-an-immunohistochemical-correlation-with-li-rads-score
#15
COMPARATIVE STUDY
Wei Xiong, Gregory Cheeney, Sooah Kim, Violetta Kolesnikova, Brooke Henninger, Jacob Alexander, Paul E Swanson, Melissa P Upton, Camtu D Truong, Matthew M Yeh
Orthotopic liver transplantation is the best option for patients with carefully selected unresectable disease because of underlying liver dysfunction. The 5-year survival rate after orthotopic liver transplantation for early detected hepatocellular carcinoma (HCC) is high, and a similar or even higher rate is reported in those with radiologically undetected HCC. This study evaluated and compared the histologic features of pretransplant radiologically undetected (14 patients, 25 tumors) versus detected (36 patients, 45 tumors) HCCs...
November 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28911220/contrast-enhanced-ultrasound-ceus-liver-imaging-reporting-and-data-system-li-rads-2017-a-review-of-important-differences-compared-to-the-ct-mri-system
#16
Tae Kyoung Kim, Seung Yeon Noh, Stephanie R Wilson, Yuko Kono, Fabio Piscaglia, Hyun-Jung Jang, Andrej Lyshchik, Christoph F Dietrich, Juergen K Willmann, Alexander Vezeridis, Claude B Sirlin
Medical imaging plays an important role in the diagnosis and management of hepatocellular carcinoma (HCC). The Liver Imaging Reporting and Data System (LI-RADS) was initially created to standardize the reporting and data collection of CT and MR imaging for patients at risk for HCC. As contrast-enhanced ultrasound (CEUS) has been widely used in clinical practice, it has recently been added to the LI-RADS. While CEUS LI-RADS shares fundamental concepts with CT/MRI LI-RADS, there are key differences between the modalities reflecting dissimilarities in the underlying methods of image acquisition and types of contrast material...
September 15, 2017: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/28881064/misdiagnosis-of-hepatocellular-carcinoma-in-patients-receiving-no-local-regional-therapy-prior-to-liver-transplant-an-analysis-of-the-organ-procurement-and-transplantation-network-explant-pathology-form
#17
Neil Mehta, Jennifer L Dodge, John P Roberts, Ryutaro Hirose, Francis Y Yao
Patients with T1 hepatocellular carcinoma (HCC) are not eligible for Model for End Stage Liver Disease (MELD) exception for liver transplant (LT) in part due to a high rate of misdiagnosis (no HCC on explant). The likelihood of misdiagnosis for T2 HCC and factors associated with misdiagnosis are unknown. We analyzed the Organ Procurement and Transplantation Network database including 5664 adults who underwent LT from 2012 to 2015 with MELD exception for T2 HCC, and searched for no evidence of HCC in the explant pathology file...
September 7, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28853673/differentiation-of-hepatocellular-carcinoma-from-other-hepatic-malignancies-in-patients-at-risk-diagnostic-performance-of-the-liver-imaging-reporting-and-data-system-version-2014
#18
Tyler J Fraum, Richard Tsai, Eric Rohe, Daniel R Ludwig, Amber Salter, ILKe Nalbantoglu, Jay P Heiken, Kathryn J Fowler
Purpose To evaluate the diagnostic performance and interrater reliability of the Liver Imaging Reporting and Data System (LI-RADS) version 2014 in differentiating hepatocellular carcinoma (HCC) from non-HCC malignancy in a population of patients at risk for HCC. Materials and Methods This retrospective HIPAA-compliant institutional review board-approved study was exempt from informed consent. A total of 178 pathology-proven malignant liver masses were identified in 178 patients at risk for HCC but without established extrahepatic malignancy from August 2012 through August 2015...
August 29, 2017: Radiology
https://www.readbyqxmd.com/read/28828680/li-rads-major-features-ct-mri-with-extracellular-agents-and-mri-with-hepatobiliary-agents
#19
Cynthia Santillan, Kathryn Fowler, Yuko Kono, Victoria Chernyak
The Liver Imaging Reporting and Data System (LI-RADS) was designed to standardize the interpretation and reporting of observations seen on studies performed in patients at risk for development of hepatocellular carcinoma (HCC). The LI-RADS algorithm guides radiologists through the process of categorizing observations on a spectrum from definitely benign to definitely HCC. Major features are the imaging features used to categorize observations as LI-RADS 3 (intermediate probability of malignancy), LIRADS 4 (probably HCC), and LI-RADS 5 (definite HCC)...
August 21, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28806321/liver-imaging-reporting-and-data-system-discordance-between-computed-tomography-and-gadoxetate-enhanced-magnetic-resonance-imaging-for-detection-of-hepatocellular-carcinoma-major-features
#20
Victoria Chernyak, Milana Flusberg, Amy Law, Mariya Kobi, Viktoriya Paroder, Alla M Rozenblit
PURPOSE: The goal of this study was to compare agreement between computed tomography (CT) and magnetic resonance imaging (MRI) in the evaluation of the major Liver Imaging Reporting and Data System (LI-RADS) features used in assessment of hepatocellular carcinoma: arterial phase hyperenhancement (APHE), portal venous phase washout (WO), capsule appearance (capsule), and largest diameter (diameter). METHODS: Patients with liver protocol CT and gadoxetate-enhanced MRI within 1 month of each other and at least 1 discrete untreated liver lesion were included...
August 12, 2017: Journal of Computer Assisted Tomography
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