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Hepatocellular carcinoma, CT

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https://www.readbyqxmd.com/read/28204855/parametric-response-mapping-of-dynamic-ct-enhanced-prediction-of-survival-in-hepatocellular-carcinoma-patients-treated-with-transarterial-chemoembolization
#1
Seung Joon Choi, Jonghoon Kim, Hyung Sik Kim, Hyunjin Park
PURPOSE: The aim of this study was to evaluate the prognostic significance of parametric response mapping (PRM) analysis for hepatocellular carcinoma (HCC) patients undergoing transarterial chemoembolization (TACE). METHODS: We recruited 65 HCC patients who underwent TACE. These patients underwent longitudinal multiphasic CT before and after TACE. We applied PRM analysis to the baseline CT before TACE and first/second follow-up CTs. The results of PRM analyses were used to stratify patients into responders and non-responders...
February 15, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28193644/tumour-thrombus-of-the-inferior-vena-cava-extending-into-the-right-atrium-in-the-setting-of-colon-cancer
#2
Daniel Meyers, Nancy A Nixon, Angela Franko, Danny Ng, Vincent C Tam
Tumour thrombus is seen in renal cell and hepatocellular carcinoma, but is rarely reported in colorectal cancer. A woman aged 46 years, with metastatic colonic adenocarcinoma, was found to have a large mass in the inferior vena cava (IVC) extending into the right atrium. Although this lesion was initially thought to be bland thrombus, imaging with contrast-enhanced CT scan and contrast-enhanced ultrasound supported the diagnosis of tumour thrombus. Despite the large size of the lesion, the patient was asymptomatic...
February 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28184942/radiological-biomarkers-for-assessing-response-to-locoregional-therapies-in-hepatocellular-carcinoma-from-morphological-to-functional-imaging-review
#3
Xiao-Dan Ye, Zuguo Yuan, Jian Zhang, Zheng Yuan
Many hepatocellular carcinoma (HCC) patients do not qualify for curative surgical intervention and are instead treated with locoregional therapies (LRTs) including ablative and endovascular therapies. Assessment of imaging response is essential in the management of HCC for determining efficacy of therapy and as a surrogate marker for improved survival. The established morphological image biomarkers for tumor burden measurement continue to be applied, as size measurement can easily be used in clinical practice...
March 2017: Oncology Reports
https://www.readbyqxmd.com/read/28181172/discrepant-imaging-findings-of-portal-vein-thrombosis-with-dynamic-computed-tomography-and-computed-tomography-during-arterial-portography-in-hepatocellular-carcinoma-possible-cause-leading-to-inappropriate-treatment-selection
#4
Hidenori Toyoda, Takashi Kumada, Toshifumi Tada, Kazuyuki Mizuno, Natsuko Kobayashi, Yosuke Inukai, Akira Takeda, Yasuhiro Sone
We encountered a patient with hepatocellular carcinoma who had discrepant imaging findings on portal vein thrombosis with portal phase dynamic computed tomography (CT) and CT during arterial portography (CTAP). CTAP, via the superior mesenteric artery and via the splenic artery, both showed a portal perfusion defect in the right hepatic lobe, indicating portal vein thrombosis in the main trunk of the right portal vein. Portal phase dynamic CT clearly depicted portal perfusion of the same hepatic area. Transarterial chemoembolization was successfully performed, but it was associated with severe liver injury...
February 8, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28180924/ct-based-radiomics-signature-a-potential-biomarker-for-preoperative-prediction-of-early-recurrence-in-hepatocellular-carcinoma
#5
Ying Zhou, Lan He, Yanqi Huang, Shuting Chen, Penqi Wu, Weitao Ye, Zaiyi Liu, Changhong Liang
PURPOSE: To develop a CT-based radiomics signature and assess its ability for preoperatively predicting the early recurrence (≤1 year) of hepatocellular carcinoma (HCC). METHODS: A total of 215 HCC patients who underwent partial hepatectomy were enrolled in this retrospective study, and all the patients were followed up at least within 1 year. Radiomics features were extracted from arterial- and portal venous-phase CT images, and a radiomics signature was built by the least absolute shrinkage and selection operator (LASSO) logistic regression model...
February 8, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28163291/production-of-insulin-like-growth-factor-ii-in-hepatocellular-carcinoma-with-recurrent-hypoglycemia-a-case-report
#6
Rieko Nakata, Hirokazu Kadoya, Naoki Sugimura, Takayuki Katsuno, Kazuki Aomatsu, Tsuyoshi Hayakawa, Sawako Uchida-Kobayashi, Tetsuo Arakawa, Hideaki Miwa
A 35-year-old woman, who was an HBV carrier, complained of fever for 2 weeks, and thus, she was admitted in our hospital. Both serum AFP and PIVKA-II levels were abnormally high, and an abdominal enhanced CT revealed the presence of multiple masses in both lobes of the liver. She was diagnosed with hepatocellular carcinoma (T4, N0, M0, and Vp4) and was treated with transcatheter arterial infusion chemotherapy. On the 4th day of her illness, her serum glucose level was 26mg/dl. Glucose infusion and intravenous hyperalimentation were not effective, and she experienced repeated hypoglycemic attacks...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/28152477/anatomic-trisegmentectomy-an-alternative-treatment-for-huge-or-multiple-hepatocellular-carcinoma-of-right-liver
#7
Changku Jia, Jie Weng, Qifan Qin, Youke Chen, Xiaolong Huang, Yu Fu
BACKGROUND: The patients with huge (≥10cm) or multiple hepatocellular carcinoma (HCC) in the right liver and insufficient size of the remnant left liver can not be performed an operation of right hemihepatectomy because of that liver failure will occur post operation. We designed anatomic trisegmentectomy in right liver to increase the ratio of future liver remnant volume (%FLRV), thus increasing resectability of huge or multiple HCC. METHODS: Thirteen patients were analyzed by preoperative CT scan for liver and tumor volumetries...
January 30, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28133933/the-possibility-of-radiotherapy-as-downstaging-to-living-donor-liver-transplantation-for-hepatocellular-carcinoma-with-portal-vein-tumor-thrombus
#8
J Y Choi, J I Yu, H C Park, C H D Kwon, J M Kim, J-W Joh, G S Choi, J B Park, S J Kim, S H Lee, W-T Cho, K W Lee, B-G Na, D K Oh, N R Lee, C W Cho, S Lee, S-K Lee
: Hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) are difficult to manage with very poor survival and due to universal recurrence after liver transplantation, they have been excluded from indication. Conformer radiation therapy (RT) has been shown to be effective in the treatment of HCC but only few trials have been reported as bridge to liver transplantation (LT) in HCC with PVTT. The purpose of our study was to evaluate the possibility of applying living donor liver transplantation (LDLT) following successful downstaging using RT in advanced HCC with PVTT...
January 30, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28133165/-simultaneous-laparoscopic-resection-of-gastric-cancer-and-hepatocellular-carcinoma
#9
Takashi Ajiki, Junichiro Yamauchi, Kento Miyazaki, Sho Yasuta, Shota Fujita, Tomoya Ikeda, Mamoru Sato, Ataru Satoh, Keiichi Shirasaki, Shin Kobayashi, Katsuo Tsuchihara, Noriko Kondo, Shuichi Ishiyama
A report of simultaneous laparoscopic resection for a patient with synchronous gastric cancer and hepatocellular carcinoma (HCC)is presented.A 76-year-old man was referred to our hospital for gastric cancer located in the antrum.In the preoperative examination, enhanced CT and MRI revealed a liver tumor located at S2 that had high contrast enhancement in the arterial phase but that was not washed out in the delayed phase.An early HCC was suspected, and simultaneous laparoscopic distal gastrectomy and partial resection of the liver was performed...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133133/-a-rare-complication-of-transcatheter-arterial-injection-for-multiple-liver-metastases-of-rectal-neuroendocrine-tumor-a-case-report
#10
Kensuke Suzuki, Nozomu Sakai, Hiroaki Shimizu, Masayuki Ohtsuka, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Shigetsugu Takano, Daisuke Suzuki, Shingo Kagawa, Hiroyuki Nojima, Masaru Miyazaki
A 50-year-old man was diagnosed with multiple bilobar liver metastases of rectal neuroendocrine tumor(NET). Although he received octreotide for 6 months and everolimus for 10 months, the liver metastases gradually increased in size. Therefore, we decided to perform transcatheter arterial infusion(TAI)with miriplatin. The serum total bilirubin level increased to 13.1 mg/dL 9 days after treatment, and it took 2 months to return to the normal range. CT scan demonstrated that most of the liver tumors had remarkably shrunk 4 months after treatment, and the patient has no sign of tumor regrowth even 12 months after treatment...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133129/-huge-hepatocellular-carcinoma-with-portal-vein-and-inferior-vena-cava-thrombi-treated-with-curative-liver-resection-and-perioperative-hepatic-arterial-infusion-chemotherapy-a-case-report
#11
Shinsaku Obara, Takeo Nomi, Ichirou Yamato, Daisuke Hokuto, Satoshi Yasuda, Chihiro Kawaguchi, Takahiro Yoshikawa, Masayuki Sho, Takatsugu Yamada, Takahiro Akahori, Shoichi Kinoshita, Minako Nagai, Hiromichi Kanehiro, Yoshiyuki Nakajima
The prognosis of hepatocellular carcinoma(HCC)with main portal vein(MPV)and/or the inferior vena cava(IVC)tumor thrombi is dismal. The management of HCC with severe tumor thrombus is complicated. In this study, we report a case of HCC with tumor thrombi in the MPV and IVC that was successfullytreated via liver resection and perioperative hepatic arterial infusion chemotherapy(HAI). A 68-year-old man was referred to our institution to treat huge HCC lesion in the right lobe of the liver. Abdominal computed tomography(CT)revealed a tumor(12 cm in diameter)in the right hepatic lobe and tumor thrombi in the MPV and IVC...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133123/-a-case-of-laparoscopic-resection-of-peritoneal-hepatocellular-carcinoma-recurrence-after-percutaneous-ethanol-injection-therapy
#12
Daisuke Muroya, Masafumi Yasunaga, Yusaku Date, Shogo Fukutomi, Nobuhisa Shirahama, Shoichiro Arai, Yohei Nakama, Ryuichi Kawahara, Hisamune Sakai, Hiroto Ishikawa, Toru Hisaka, Jun Akiba, Yoshito Akagi, Hiroyuki Tanaka, Koji Okuda
Needle tract implantation after percutaneous ethanol injection therapy(PEIT)for hepatocellular carcinoma(HCC)is rare. Surgical treatment of such HCC implants is still controversial. We herein report the case of a patient who underwent laparoscopic resection for peritoneal dissemination after PEIT. An 81-year-old man underwent PEIT for primary HCC at another hospital. Thereafter, percutaneous radiofrequency ablation(RFA)was performed twice for intrahepatic recurrence. After the second RFA, a mass lesion was detected at the subhepatic space on computed tomography(CT)...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133064/-treatment-experience-with-sorafenib-for-lung-metastases-of-hepatocellular-carcinoma-complicated-with-interstitial-pneumonia
#13
Takashi Shuto, Masahiro Murakami, Junzo Shimizu, Chikato Koga, Akinobu Yasuyama, Tae Matsumura, Chizu Kameda, Ryohei Kawabata, Masaki Hirota, Masato Yoshikawa, Shingo Noura, Junichi Hasegawa
A 74-year-old man was diagnosed with hepatocellular carcinoma(HCC; S4/8)and underwent anterior segment resection of the liver in 2015. He was hospitalized with a wound infection 2 months after surgery. On the 8th hospital day he complained of respiratory discomfort. A CT showed multiple lung metastases and a ground-glass appearance in both lungs. We diagnosed interstitial pneumonia with metastatic lung tumors. Steroid therapy was performed for the interstitial pneumo- nia(prednisolone 1,000mg/day×3 days), and sorafenib therapy was initiated for the metastatic lung cancer(starting from 200mg/day to 800mg/day)...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133049/-advanced-digestive-cancer-in-super-elderly-patients-more-than-85-years-old-two-cases-that-required-major-invasive-surgery
#14
Shigeru Ueda, Kenichi Nomoto, Tomonori Nakanoko, Hirofumi Hasegawa, Tomonobu Gion, Masayuki Kitamura
Case 1 involved an 87-year-old woman. She had increased serum amylase levels, and intraductal papillary mucinous adenocarcinoma( IPMC)in the accessory pancreatic duct was diagnosed following various medical examinations. Radical surgery is possible for such a lesion when there are no issues detected following evaluation. The patient and her family decided that she should undergo surgery; therefore, pancreatoduodenectomy was performed for Stage III IPMC. Various morbidities required medical treatment, but she was finally discharged from hospital 89 days after surgery...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133032/-prediction-of-treatment-effect-of-transcatheter-arterial-chemoembolization-for-hepatocellular-carcinoma-using-computed-tomography-ct-attenuation-value
#15
Shunichi Shiozawa, Takebumi Usui, Kotaro Kuhara, Akira Tsuchiya, Tatsuomi Miyauchi, Teppei Kono, Shinichi Asaka, Kentaro Yamaguchi, Hajime Yokomizo, Takeshi Shimakawa, Kazuhiko Yoshimatsu, Takao Katsube, Yoshihiko Naritaka
AIM: In general, transcatheter arterial chemoembolization(TACE)can obtain a high therapeutic effect on hypervascular tumors, but the definition of"hypervascular"is unclear. In this study, stainedtumor images on enhancedcomputedtomography( CT)were assessedaccord ing to CT-attenuation value. We investigatedwhether it is possible to estimate the treatment effect(TE)of TACE for hepatocellular carcinomas(HCCs). STUDY POPULATION AND METHODS: We studied 50 patients with unresectable HCCs who underwent TACE...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28126475/clinical-benefits-of-new-immobilization-system-for-hypofractionated-radiotherapy-of-intrahepatic-hepatocellular-carcinoma-by-helical-tomotherapy
#16
Yong Hu, Yong-Kang Zhou, Yi-Xing Chen, Shi-Ming Shi, Zhao-Chong Zeng
OBJECTIVE: A comprehensive clinical evaluation was conducted, assessing the Body Pro-Lok immobilization and positioning system to facilitate hypofractionated radiotherapy of intrahepatic hepatocellular carcinoma (HCC), using helical tomotherapy to improve treatment precision. METHODS: Clinical applications of the Body Pro-Lok system were investigated (as above) in terms of interfractional and intrafractional setup errors and compressive abdominal breath control...
January 23, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28123741/hepatocellular-carcinoma-with-inferior-vena-caval-and-right-atrial-tumor-thrombi-and-massive-pulmonary-artery-embolism-a-case-report
#17
Jian Huang, Ze-Ya Pan, Li Li, Bei-Ge Jiang, Fang-Ming Gu, Zhen-Guang Wang, Zhi-Hong Wang, Wei-Ping Zhou
The aim of the present study was to report the case of a 55-year-old female patient with a sizeable (7.1×6.2 cm) hepatocellular carcinoma (HCC), who succumbed to massive pulmonary artery embolism. The main symptoms included sudden thoracodynia, dyspnea and transient coma. The initial diagnosis was HCC according to the typical abdominal ultrasound and triple-phase abdominal computed tomography (CT) findings, chronic hepatitis B infection and elevated α-fetoprotein levels (1,036 µg/l; normal, 0-20 µg/l). Two days following admission, the patient developed recurrent chest pain and shortness of breath...
January 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28114226/predictive-value-of-18f-fdg-pet-ct-for-vascular-invasion-in-patients-with-hepatocellular-carcinoma-before-liver-transplantation
#18
Chun-Yi Lin, Chiung-Wei Liao, Lu-Yen Chu, Kuo-Yang Yen, Long-Bin Jeng, Cheng-Nan Hsu, Cheng-Li Lin, Chia-Hung Kao
BACKGROUND: Positron emission tomography-computed tomography using F-fluorodeoxyglucose (F-FDG PET/CT) has been widely used in oncology. Vascular invasion of hepatocellular carcinoma (HCC) is associated with a high risk of tumor recurrence and low survival rates after liver transplantation (LT). This retrospective study determined the predictive value of F-FDG PET/CT for vascular invasion in patients with HCC before LT. METHODS: Sixty-five patients with HCC who underwent F-FDG PET/CT before LT were retrospectively included between January 2010 and July 2012...
January 20, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28109724/the-role-of-cone-beam-ct-in-transcatheter-arterial-chemoembolization-for-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#19
Leland Pung, Moiz Ahmad, Kerstin Mueller, Jarrett Rosenberg, Christopher Stave, Gloria L Hwang, Rajesh Shah, Nishita Kothary
PURPOSE: To review available evidence for use of cone-beam CT during transcatheter arterial chemoembolization in hepatocellular carcinoma (HCC) for detection of tumor and feeding arteries. MATERIALS AND METHODS: Literature searches were conducted from inception to May 15, 2016, in PubMed (MEDLINE), Scopus, and Cochrane Central Register of Controlled Trials. Searches included "cone beam," "CBCT," "C-arm," "CACT," "cone-beam CT," "volumetric CT," "volume computed tomography," "volume CT," AND "liver," "hepatic*," "hepatoc*...
January 18, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28109674/single-center-nonrandomized-clinical-trial-to-assess-the-safety-and-efficacy-of-irreversible-electroporation-ire-ablation-of-liver-tumors-in-humans-short-to-mid-term-results
#20
P Frühling, A Nilsson, F Duraj, U Haglund, A Norén
INTRODUCTION: A single-center nonrandomized clinical trial was performed to assess the safety and efficacy of IRE ablation of liver tumors in humans. METHODS: 38 malignant liver tumors on 30 patients were treated with IRE between September 2011 and September 2014. Treatment was with curative intent, and the diagnoses were colorectal cancer with liver metastases (CRLM) (n = 23), hepatocellular carcinoma (HCC) (n = 8) and other metastasis (n = 7). Patients were selected when surgery, radiofrequency ablation (RFA) or microwave ablation (MWA) was not an option, and when they met inclusion criteria (tumor size < 3 cm, 1-2 tumors)...
January 11, 2017: European Journal of Surgical Oncology
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