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Hepatocellular carcinoma, CT

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https://www.readbyqxmd.com/read/28433483/functional-image-guided-stereotactic-body-radiation-therapy-planning-for-patients-with-hepatocellular-carcinoma
#1
Uranchimeg Tsegmed, Tomoki Kimura, Takeo Nakashima, Yuko Nakamura, Toru Higaki, Nobuki Imano, Yoshiko Doi, Masahiro Kenjo, Shuichi Ozawa, Yuji Murakami, Kazuo Awai, Yasushi Nagata
The aim of the current planning study is to evaluate the ability of gadoxetate disodium-enhanced magnetic resonance imaging (EOB-MRI)-guided stereotactic body radiation therapy (SBRT) planning by using intensity-modulated radiation therapy (IMRT) techniques in sparing the functional liver tissues during SBRT for hepatocellular carcinoma. In this study, 20 patients with hepatocellular carcinoma were enrolled. Functional liver tissues were defined according to quantitative liver-spleen contrast ratios ≥ 1...
April 19, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28429188/18f-fluorodeoxyglucose-uptake-on-positron-emission-tomography-computed-tomography-is-associated-with-metastasis-and-epithelial-mesenchymal-transition-in-hepatocellular-carcinoma
#2
Misu Lee, Jeong Yong Jeon, Micheal L Neugent, Jung-Whan Kim, Mijin Yun
Hepatocellular carcinoma (HCC) is the fifth leading cause of cancer mortality worldwide. Several studies have investigated the relationship between (18)F-fluorodeoxyglucose ((18)F-FDG) uptake on positron emission tomography and the prognosis of patients with HCC, although the relationship between (18)F-FDG uptake and expression of EMT-related proteins in these patients remains unclear. We retrospectively enrolled 116 patients with HCC treated by curative surgical resection and who underwent (18)F-FDG positron emission tomography/computed tomography (PET/CT) for preoperative staging...
April 20, 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28420329/contrast-enhanced-us-with-perfluorobutane-sonazoid-used-as-a-surveillance-test-for-hepatocellular-carcinoma-hcc-in-cirrhosis-scan-an-exploratory-cross-sectional-study-for-a-diagnostic-trial
#3
Ji Hoon Park, Mi-Suk Park, So Jung Lee, Woo Kyoung Jeong, Jae Young Lee, Min Jung Park, Kyunghwa Han, Chung Mo Nam, Seong Ho Park, Kyoung Ho Lee
BACKGROUND: Ultrasonography (US) is widely used as a standard surveillance tool for patients who are at a high risk of having hepatocellular carcinoma (HCC); however, conventional B-mode US appears to be insufficient in order to ensure the early detection of HCC. Perfluorobutane allows very stable Kupffer phase imaging for at least 60 min, which is tolerable for examinations of the entire liver. The purpose of our study is to evaluate the added value of contrast-enhanced US using perfluorobutane to that of conventional B-mode US as an HCC surveillance tool for patients with liver cirrhosis...
April 18, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28418840/distinct-mdct-imaging-features-to-differential-diagnosis-of-hepatic-paragonimiasis-and-small-hepatocellular-carcinoma
#4
Sheng Zhang, Si-Ming Xie, Yong-Hua Chen, Xu-Bao Liu, Gang Mai
We used multi-row detector computed tomography (MDCT) to identify the distinguishing characteristics of hepatic paragonimiasis and small hepatocellular carcinoma lesions. We analyzed a cohort of 60 patients, of which 26 had hepatic paragonimiasis and 34 with a small (≤ 3cm) hepatocellular carcinoma. MDCT detected 65 lesions that were retrospectively reviewed and analyzed based on their imaging features. Both groups showed distinct MDCT imaging features that could contribute to an accurate diagnosis. In the paragonimiasis group, 75% (21/28) lesions were located in the hepatic subcapsular region, whereas only 10...
March 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28416747/the-tert-promoter-mutation-incidence-is-modified-by-germline-tert-rs2736098-and-rs2736100-polymorphisms-in-hepatocellular-carcinoma
#5
Xiaotian Yuan, Guanghui Cheng, Jingya Yu, Shunzhen Zheng, Chao Sun, Qing Sun, Kailin Li, Zhaomin Lin, Tiantian Liu, Ping Li, Yiteng Xu, Feng Kong, Magnus Bjorkholm, Dawei Xu
Telomerase activation via induction of the catalytic component telomerase reverse transcriptase (TERT) plays essential roles in malignant transformation. TERT promoter-activating mutations were recently identified as a novel mechanism to activate telomerase in hepatocellular carcinoma (HCC) and many other malignancies. In addition, single nucleotide polymorphisms (SNPs) in the TERT rs2736098 and rs2736100 are significantly associated with cancer susceptibility. It is currently unclear whether different germline TERT variants modify TERT promoter mutations...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28416360/primary-hepatic-angiosarcoma-and-liver-transplantation-radiological-surgical-histological-findings-and-clinical-outcome
#6
M Tran Minh, A Mazzola, F Perdigao, F Charlotte, G Rousseau, F Conti
Angiosarcoma is a rare type of soft tissue sarcoma that accounts for less than 1% of all sarcomas and only 2% of all primary hepatic tumours. Thorotrast, arsenic, and vinyl chloride monomer are frequently listed as occupational exposure risks. The estimated latency is long (10-40 years) in occupational cases and very long (60 years or more) in non-occupational cases. The symptoms and CT-scan appearance of hepatic angiosarcoma (HAS) are non-specific. We present a case of a 65-year-old Caucasian male with history of cryptogenic cirrhosis, low alpha-foetoprotein levels and a single, 4-cm nodule of potential atypical hepatocellular carcinoma (no washout at MRI and CT-scan) in segment VIII...
April 14, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28415817/an-updated-meta-analysis-of-23-case-control-studies-on-the-association-between-mir-34b-c-polymorphism-and-cancer-risk
#7
Hua Li, Shuling Diao, Jingsen Li, Baoxin Ma, Shuanghu Yuan
The association between in microRNA-34b/c gene rs4938723 polymorphisms and cancer risk remains inconclusive. This meta-analysis was performed to analyze the association between microRNA-34b/c rs4938723 polymorphism and risk for cancer development. In total, 304 studies from PubMed, Embase, Web of Science, Wanfang, and Chinese National Knowledge Infrastructure databases were examined, and 23 studies were included in this meta-analysis. The 23 selected studies involved 10,812 cancer cases and 11,719 controls...
March 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415691/a-potentially-functional-variant-of-arid1b-interacts-with-physical-activity-in-association-with-risk-of-hepatocellular-carcinoma
#8
Li Liu, Nana Tian, Chengyu Zhou, Xinqi Lin, Weibiao Lv, Zhifeng Lin, Zibo Lin, Yongfen Qi, Yi Yang, Sidong Chen, Xinfa Yu, Yanhui Gao
The tumor suppressor role of AT-rich interactive domain containing protein 1B (ARID1B) has drawn much attention in area of cancer etiology. However, it had remained unknown whether or not genetic variants of ARID1B involved in development of hepatocellular carcinoma (HCC). In this study, three putatively functional variants in ARID1B (rs73013281C>T, rs167007A>G, and rs9397984C>T) were selected using bioinformatics tools, and a case-control study of 611 cases and 614 controls was conducted to investigate genetic associations with HCC risk in a Southern Chinese population...
March 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28412761/preoperative-assessment-of-hepatocellular-carcinoma-with-split-bolus-combined-phase-contrast-enhanced-computed-tomography
#9
Jian Jiang, Ke Wang, Yufeng Xu, Jianxin Liu, Jingjing Luo, Xin Tao, Xiaoying Wang
BACKGROUND The aim of this study was to investigate the feasibility of a split-bolus combined phase contrast-enhanced computed tomography protocol in evaluation of liver vasculature in hepatocellular carcinoma (HCC) patients for the purpose of surgery guidance. MATERIAL AND METHODS Two groups of patients were recruited for the study: 24 consecutive cases of HCC who underwent multiphasic CT examination, and 22 consecutive cases who afterwards underwent split-bolus combined phase CT examination. The multiphasic protocol included an unenhanced scan and 3 image acquisitions after contrast injection...
April 16, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28409202/imaging-evaluation-of-ablative-margin-and-index-tumor-immediately-after-radiofrequency-ablation-for-hepatocellular-carcinoma-comparison-between-multidetector-row-ct-and-mr-imaging
#10
Sung Mo Kim, Sang Soo Shin, Byung Chan Lee, Jin Woong Kim, Suk Hee Heo, Hyo Soon Lim, Yong Yeon Jeong
PURPOSE: To prospectively compare multidetector-row CT (MDCT) and MR imaging (MRI) in the assessment of the ablative margin (AM) and index tumor immediately after radiofrequency (RF) ablation for hepatocellular carcinoma (HCC) and assess whether non-contrast MRI with limited sequences (T1- and T2-weighted imaging only) was superior to a conventional MDCT protocol. METHODS: A total of 33 consecutive patients with 42 HCCs were included in this study. Both MDCT and MR images were independently reviewed by two radiologists regarding the ability to visually discriminate between the AM and index tumor, and the AM status within ablation zones...
April 13, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28401484/vascular-microinvasion-from-hepatocellular-carcinoma-ct-findings-and-pathologic-correlation-for-the-best-therapeutic-strategies
#11
Alfonso Reginelli, Angelo Vanzulli, Cristiano Sgrazzutti, Luca Caschera, Nicola Serra, Antonio Raucci, Fabrizio Urraro, Salvatore Cappabianca
Recurrence of HCC reduces survival rates in patients treated with surgery, and one of the most relevant risk factors for tumour recurrence is microvascular invasion (mVI). The identification of mVI on preoperative examinations could improve surgical planning's and techniques so as to reduce the risk of tumour recurrence. During our study, we have revised 101 CT examinations of the liver performed on patients diagnosed with solitary HCC who had surgical treatment and pathological analysis of the specimens for mVI in order to detect CT signs which could be reliable in mVI prediction...
May 2017: Medical Oncology
https://www.readbyqxmd.com/read/28397480/genetic-polymorphism-of-mthfr-c677t-influences-susceptibility-to-hbv-related-hepatocellular-carcinoma-in-a-chinese-population-a-case-control-study
#12
Kunyan Qiao, Shitian Zhang, Congdoanh Trieu, Qinghai Dai, Zhixiao Huo, Yanan Du, Wei Lu, Wei Hou
BACKGROUND: Methylene tetrahydrofolate reductase (MTHFR) is the key enzyme of folic acid metabolism and the C677T mutation is associated with decreased enzyme activity. Several studies have shown its regulatory role in carcinogenesis and tumor growth. HBV (hepatitis B virus)-related HCC (hepatocellular carcinoma) is one of the most common liver cancers worldwide. Therefore, the present case-control study aimed to investigate the role of genetic polymorphism of MTHFR C677T in the development and progression of HBV-related HCC in a Chinese population...
April 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28392502/contrast-enhanced-computed-tomography-plus-gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic-acid-enhanced-magnetic-resonance-imaging-for-gross-classification-of-hepatocellular-carcinoma
#13
Chuang Chen, Hui Zhao, Xu Fu, LuoShun Huang, Min Tang, XiaoPeng Yan, ShiQuan Sun, WenJun Jia, Liang Mao, Jiong Shi, Jun Chen, Jian He, Jin Zhu, YuDong Qiu
Accurate gross classification through imaging is critical for determination of hepatocellular carcinoma (HCC) patient prognoses and treatment strategies. The present retrospective study evaluated the utility of contrast-enhanced computed tomography (CE-CT) combined with gadolinium-ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging (EOB-MRI) for diagnosis and classification of HCCs prior to surgery. Ninety-four surgically resected HCC nodules were classified as simple nodular (SN), SN with extranodular growth (SN-EG), confluent multinodular (CMN), or infiltrative (IF) types...
February 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28390113/regulation-of-acetate-utilization-by-monocarboxylate-transporter-1-mct1-in-hepatocellular-carcinoma-hcc
#14
Jeong Jeon, Misu Lee, Sang Whang, Jung-Whan Kim, Arthur Cho, Mijin Yun
Altered energy metabolism is a biochemical fingerprint of cancer cells. Hepatocellular carcinoma (HCC) shows reciprocal18F-Fluorodeoxyglucose (FDG) and 11C-acetate uptake, as revealed by positron emission tomography/computed tomography (PET/CT). Previous studies have focused on the role of FDG uptake in cancer cells; in this study, we evaluated the mechanism and roles of 11C-acetate uptake in human HCCs and cell lines. The expression of monocarboxylate transporters (MCTs) was assessed to determine the transporters of 11C-acetate uptake in HCC cell lines and human HCCs with different 11C-acetate uptake...
March 23, 2017: Oncology Research
https://www.readbyqxmd.com/read/28387640/fructose-1-6-bisphosphatase-1-reduces-18-f-fdg-uptake-in-hepatocellular-carcinoma
#15
Ruohua Chen, Jiajin Li, Xiang Zhou, Jianjun Liu, Gang Huang
Purpose To determine whether fructose 1,6-bisphosphatase 1 (FBP1) expression is associated with fluorine 18 ((18)F) fluorodeoxyglucose (FDG) accumulation in patients with hepatocellular carcinoma (HCC) and to investigate how FBP1 expression and (18)F FDG uptake are related to tumor differentiation grade and metabolism and whether the molecular mechanism involves hypoxia-inducible factor 1-α (HIF1A) transcriptional activity. Materials and Methods This retrospective study was approved by the institutional review board with informed consent...
April 6, 2017: Radiology
https://www.readbyqxmd.com/read/28384187/target-localization-of-3d-versus-4d-cone-beam-computed-tomography-in-lipiodol-guided-stereotactic-radiotherapy-of-hepatocellular-carcinomas
#16
Mark Chan, Chi Leung Chiang, Venus Lee, Steven Cheung, Ronnie Leung, Matthew Wong, Frankle Lee, Oliver Blanck
BACKGROUND: Aim of this study was to comparatively evaluate the accuracy of respiration-correlated (4D) and uncorrelated (3D) cone beam computed tomography (CBCT) in localizing lipiodolized hepatocellular carcinomas during stereotactic body radiotherapy (SBRT). METHODS: 4D-CBCT scans of eighteen HCCs were acquired during free-breathing SBRT following trans-arterial chemo-embolization (TACE) with lipiodol. Approximately 1320 x-ray projections per 4D-CBCT were collected and phase-sorted into ten bins...
2017: PloS One
https://www.readbyqxmd.com/read/28381784/a-case-of-extrahepatic-growth-type-hepatocellular-carcinoma-presenting-with-bleeding-from-colonic-metastasis
#17
Kazunari Tanaka, Kunihiko Tsuji, Takeshi Matsui, Jong-Hon Kang, Yasuo Sakurai, Akihiro Takiyama, Toshiya Shinohara, Hiroyuki Maguchi
A 60-year-old woman visited our hospital due to hematochezia. Colonoscopy revealed a 50-mm-diameter submucosal tumor with ulceration of the left side of the transverse colon, and magnetic resonance imaging (MRI) demonstrated the presence of small hepatic nodules. Submucosal tumor of the colon with liver metastasis was therefore diagnosed. To prevent tumor bleeding, we performed partial transverse colectomy. The histopathological diagnosis was moderately differentiated hepatocellular carcinoma presenting as a submucosal tumor with a high frequency of vascular invasion...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/28372458/hepatocellular-carcinoma-presenting-with-budd-chiari-syndrome-right-atrial-thrombus-and-pulmonary-emboli
#18
Luís C Lourenço, David V Horta, Sara F Alberto, Jorge Reis
A 47-year-old patient presented with a two-week history of right upper quadrant pain, abdominal distention and new onset of shortness of breath. He had a history of intravenous drug abuse, no alcohol consumption and denied any known liver disease. On physical examination, he was tachypneic and had dullness in the flanks. His blood analysis at admission was as follows: hemoglobin, 12.9 g/dL; leukocyte count, 6,800/uL; platelet count, 63,000/uL; INR, 2.1; serum creatinine, 1.27 mg/dL; liver biochemistry tests were notable for marginal derangement, HBsAg was negative, anti-HCV was positive, HCV RNA was 367,498 IU/ml and alpha-fetoprotein was 992 mg/dL...
April 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28369930/hepatocellular-carcinoma-with-intracranial-metastasis-in-a-japanese-macaque-macaca-fuscata
#19
Takako Miyabe-Nishiwaki, Akihiro Hirata, Akihisa Kaneko, Akiyo Ishigami, Yoko Miyamoto, Atsushi Yamanaka, Keishi Owaki, Hiroki Sakai, Tokuma Yanai, Juri Suzuki
BACKGROUND: A 23-year-old male Japanese macaque (Macaca fuscata) showed left ptosis, which progressed to exophthalmos. METHODS: The macaque underwent a clinical examination, CT and MRI, and was euthanized. Necropsy and histopathological examination were performed after euthanasia. RESULTS: The CT revealed and MRI confirmed an intracranial mass at the skull base with orbital extension. At necropsy, there were a large hepatic mass and an intracranial mass compressing the left temporal lobe of the brain...
April 3, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28363694/cost-effectiveness-of-eob-mri-for-hepatocellular-carcinoma-in-japan
#20
Akihiro Nishie, Satoshi Goshima, Hiroki Haradome, Etsuro Hatano, Yasuharu Imai, Masatoshi Kudo, Masanori Matsuda, Utaroh Motosugi, Satoshi Saitoh, Kengo Yoshimitsu, Bruce Crawford, Eliza Kruger, Graeme Ball, Hiroshi Honda
PURPOSE: The objective of the study was to evaluate the cost-effectiveness of gadoxetic acid-enhanced magnetic resonance imaging (EOB-MRI) in the diagnosis and treatment of hepatocellular carcinoma (HCC) in Japan compared with extracellular contrast media-enhanced MRI (ECCM-MRI) and contrast media-enhanced computed tomography (CE-CT) scanning. METHODS: A 6-stage Markov model was developed to estimate lifetime direct costs and clinical outcomes associated with EOB-MRI...
March 28, 2017: Clinical Therapeutics
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