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Hepatocellular carcinoma, CT

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https://www.readbyqxmd.com/read/29333117/baseline-tumor-lipiodol-uptake-after-transarterial-chemoembolization-for-hepatocellular-carcinoma-identification-of-a-threshold-value-predicting-tumor-recurrence
#1
Yusuke Matsui, Masahiro Horikawa, Younes Jahangiri Noudeh, John A Kaufman, Kenneth J Kolbeck, Khashayar Farsad
Background: The aim of the study was to evaluate the association between baseline Lipiodol uptake in hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE) with early tumor recurrence, and to identify a threshold baseline uptake value predicting tumor response. Patients and methods: A single-institution retrospective database of HCC treated with Lipiodol-TACE was reviewed. Forty-six tumors in 30 patients treated with a Lipiodol-chemotherapy emulsion and no additional particle embolization were included...
December 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/29326816/immune-checkpoint-inhibition-prospects-for-prevention-and-therapy-of-hepatocellular-carcinoma
#2
REVIEW
Caryn L Elsegood, Janina Ee Tirnitz-Parker, John K Olynyk, George Ct Yeoh
The global prevalence of liver cancer is rapidly rising, mostly as a result of the amplified incidence rates of viral hepatitis, alcohol abuse and obesity in recent decades. Treatment options for liver cancer are remarkably limited with sorafenib being the gold standard for advanced, unresectable hepatocellular carcinoma but offering extremely limited improvement of survival time. The immune system is now recognised as a key regulator of cancer development through its ability to protect against infection and chronic inflammation, which promote cancer development, and eliminate tumour cells when present...
November 2017: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/29324837/health-economic-assessment-of-gd-eob-dtpa-mri-versus-eccm-mri-and-multi-detector-ct-for-diagnosis-of-hepatocellular-carcinoma-in-china
#3
Xiaoning He, Jing Wu, Anke-Peggy Holtorf, Harald Rinde, Shuangshuang Xie, Wen Shen, Jiancun Hou, Xuehua Li, Ziping Li, Jiaming Lai, Yuting Wang, Lin Zhang, Jian Wang, Xuesong Li, Kuansheng Ma, Feng Ye, Han Ouyang, Hong Zhao
Limited data exists in China on the comparative cost of gadolinium ethoxybenzyl diethylenetriamine magnetic resonance imaging (Gd-EOB-DTPA-MRI) with other imaging techniques. This study compared the total cost of Gd-EOB-DTPA-MRI with multidetector computed tomography (MDCT) and extracellular contrast media-enhanced MRI (ECCM-MRI) as initial imaging procedures in patients with suspected hepatocellular carcinoma (HCC). We developed a decision-tree model on the basis of the Chinese clinical guidelines for HCC, which was validated by clinical experts from China...
2018: PloS One
https://www.readbyqxmd.com/read/29312973/critical-appraisal-of-chinese-2017-guideline-on-the-management-of-hepatocellular-carcinoma
#4
REVIEW
Di-Yang Xie, Zheng-Gang Ren, Jian Zhou, Jia Fan, Qiang Gao
Hepatocellular carcinoma (HCC) is the fourth most common and the third most lethal cancer in China. An updated version of consensus-based recommendations on the management of HCC has been recently published by a multidisciplinary group of Chinese experts including liver surgeons, hepatic oncologists, radiologists and pathologists. Major changes have been made to the diagnostic criteria. In addition to dynamic multi-detector computed tomography (CT) and magnetic resonance imaging (MRI), gadoxetic acid-enhanced MRI and contrast-enhanced ultrasound (CEUS) are added to the diagnostic imaging tests...
December 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/29312871/patient-specific-three-dimensional-printing-for-pre-surgical-planning-in-hepatocellular-carcinoma-treatment
#5
Elizabeth Perica, Zhonghua Sun
Background: Recently, three-dimensional (3D) printing has shown great interest in medicine, and 3D printed models may be rendered as part of the pre-surgical planning process in order to better understand the complexities of an individual's anatomy. The aim of this study is to investigate the feasibility of utilising 3D printed liver models as clinical tools in pre-operative planning for resectable hepatocellular carcinoma (HCC) lesions. Methods: High-resolution contrast-enhanced computed tomography (CT) images were acquired and utilized to generate a patient-specific 3D printed liver model...
December 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29310401/ectopic-hepatocellular-carcinoma-manifesting-multiple-abdominal-masses-a-case-report
#6
RenAn Jin, Qingsong Yu, Xiao Liang
RATIONALE: Ectopic hepatocellular carcinoma (HCC) is a rare disease that mostly originates from an ectopic liver. PATIENT CONCERNS: The patient was admitted with upper abdominal distention for 3 months, which aggravated after meal. DIAGNOSES: A contrast-enhanced computed tomography (CT) scan revealed multiple abdominal masses. After exploratory laparotomy and histological examination, the patient was diagnosed as ectopic HCC. INTERVENTIONS: Exploratory laparotomy was performed for the purpose of diagnosis and treatment...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29305365/rash-and-subcutaneous-fat-necrosis-after-deb-tace-with-doxorubicin
#7
Ahmed Gamal Elsayed, James M Martin, Toni Pacioles
A 73-year-old woman with hepatocellular carcinoma localised to the liver was treated with doxorubicin-loaded drug-eluting beads through transcatheter arterial chemoembolisation (DEB-TACE). She developed subcutaneous, erythematous, tender nodules in her abdomen 3 days after the procedure. PET/CT scan that was done to evaluate for evidence of disease progression showed mild avidity of these nodules. Biopsy showed fatty necrosis. Nodules started to improve spontaneously 2 weeks after onset. At 8 weeks after onset, lesions stabilised in size and the associated tenderness and erythema resolved...
January 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29279169/hepatocellular-carcinoma-treated-with-sorafenib-arterial-tumor-perfusion-in-dynamic-contrast-enhanced-ct-as-early-imaging-biomarkers-for-survival
#8
Yuko Nakamura, Tomokazu Kawaoka, Toru Higaki, Wataru Fukumoto, Yukiko Honda, Makoto Iida, Chikako Fujioka, Masao Kiguchi, Hiroshi Aikata, Kazuaki Chayama, Kazuo Awai
OBJECTIVES: To investigate whether hepatic perfusion CT yields early imaging biomarkers predictive of the prognosis of hepatocellular carcinoma (HCC) patients treated with sorafenib. METHODS: We evaluated 36 HCC patients who underwent hepatic perfusion CT before- and one week after sorafenib therapy. We measured arterial and portal perfusion in the hepatic tumor and liver parenchyma [(AP)(PP)tumor], [(AP)(PP)liver]. The perfusion ratio was calculated by dividing the post- by the pre-sorafenib value...
January 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29261620/68ga-psma-avid-primary-adenocarcinoma-of-the-lung-with-complementary-low-18f-fdg-uptake
#9
Mads Ryø Jochumsen, Lars Christian Gormsen, Gitte Lund Nielsen
Ga-PSMA PET/CT scan on a 70-year-old man with recently diagnosed prostate cancer revealed a spiculating nodule in the apex of the left lung with intense Ga-PSMA uptake. The nodule had no pathological F-FDG uptake and turned out to be a primary adenocarcinoma of the lung. Cases with complementary pattern of uptake in F-FDG and Ga-PSMA in metastatic clear cell renal carcinoma and in well-differentiated hepatocellular carcinoma have previously been reported; however, this case illustrates that this unusual pattern can also be present in primary lung cancer...
December 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29234638/prospective-comparison-of-gd-eob-dtpa-enhanced-mri-with-dynamic-ct-for-detecting-recurrence-of-hcc-after-radiofrequency-ablation
#10
Yasuharu Imai, Kazuhiro Katayama, Masatoshi Hori, Takayuki Yakushijin, Kenji Fujimoto, Toshifumi Itoh, Takumi Igura, Mitsuru Sakakibara, Manabu Takamura, Masakatsu Tsurusaki, Hiroto Takahashi, Katsuyuki Nakanishi, Noriaki Usuki, Koh Tsuji, Hiroshi Ohashi, Tonsok Kim, Tetsuo Takehara, Takamichi Murakami
Background: We prospectively compared the efficacy of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) with that of dynamic multidetector computed tomography (MDCT) for detection of recurrent hypervascular hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA). Methods: Institutional review board approval and written informed consent were obtained for this multicenter study. Ninety-seven HCC patients treated with curative RFA underwent both Gd-EOB-DTPA-enhanced MRI and dynamic MDCT every 3-4 months...
November 2017: Liver Cancer
https://www.readbyqxmd.com/read/29233162/sarcomatoid-hepatocellular-carcinoma-shc-a-case-report
#11
Yingying Yu, Yanping Zhong, Jingyu Wang, Di Wu
BACKGROUND: Sarcomatoid hepatocellular carcinoma (SHC) is a rare malignant hepatic tumor. Recurrent interventional therapies such as transcatheter arterial chemo-embolization (TACE), radiofrequency ablation (RFA), and percutaneous ethanol injection have been reported previously utilized in a majority of SHC cases. To date, the exact pathogenic mechanisms underlying sarcomatoid transformation of hepatocellular carcinoma (HCC) remain unknown. CASE PRESENTATION: In this study, we report a 68-year-old female SHC patient admitted to our hospital due to discrete abdominal distention for more than 20 days...
December 12, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29221801/donor-polymorphisms-of-toll-like-receptor-4-rs1927914-associated-with-the-risk-of-hepatocellular-carcinoma-recurrence-following-liver-transplantation
#12
Guangjun Shi, Chuanxu Wang, Ping Zhang, Lisha Ji, Shifeng Xu, Xueying Tan, Hao Li
BACKGROUND: Hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) severely restricts the long-term survival of patients. Toll-like receptor 4 (TLR4) has been considered to be involved in hepatocarcinogenesis and metastasis. Additionally, there is a study demonstrating the significant association between TLR4 gene rs1927914 polymorphism and HCC, but no study investigated the association of the TLR4 rs1927914 polymorphism with the risk of HCC recurrence following LT...
December 5, 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/29204748/imaging-the-expression-of-glypican-3-in-hepatocellular-carcinoma-by-pet
#13
Zhen Wang, Yan-Jiang Han, Shun Huang, Meng Wang, Wen-Lan Zhou, Hong-Sheng Li, Quan-Shi Wang, Hu-Bing Wu
The glypican-3 (GPC3) receptor is overexpressed in hepatocellular carcinoma (HCC) and is a potential diagnostic and therapeutic target. GPC3-targeted molecular imaging will be helpful to differentiate diagnosis and guide therapy. In the present study, we will develop a novel PET probe for imaging the expression of GPC-3. L5 (sequence: RLNVGGTYFLTTRQ), a GPC3 targeting peptide, was labeled with 5-carboxyfluorescein (FAM) and 18F-fluoride. Cell binding tests were performed to identify the binding specificity of FAM-L5 and 18F radiolabeled peptide...
December 4, 2017: Amino Acids
https://www.readbyqxmd.com/read/29196855/ultrasound-ultrasound-image-overlay-fusion-improves-real-time-control-of-radiofrequency-ablation-margin-in-the-treatment-of-hepatocellular-carcinoma
#14
Yasunori Minami, Tomohiro Minami, Satoru Hagiwara, Hiroshi Ida, Kazuomi Ueshima, Naoshi Nishida, Takamichi Murakami, Masatoshi Kudo
OBJECTIVES: To assess the clinical feasibility of US-US image overlay fusion with evaluation of the ablative margin in radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). METHODS: Fifty-three patients with 68 HCCs measuring 0.9-4.0 cm who underwent RFA guided by US-US overlay image fusion were included in this retrospective study. By an overlay of pre-/postoperative US, the tumor image could be projected onto the ablative hyperechoic zone. Therefore, the ablative margin three-dimensionally could be shown during the RFA procedure...
December 1, 2017: European Radiology
https://www.readbyqxmd.com/read/29193248/impact-of-muscle-volume-and-function-decline-in-patients-undergoing-surgical-resection-for-hepatocellular-carcinoma
#15
Atsushi Hiraoka, Yasuhiro Otsuka, Hideki Kawasaki, Hirofumi Izumoto, Hidetaro Ueki, Shogo Kitahata, Toshihiko Aibiki, Tomonari Okudaira, Hiroka Yamago, Yuji Miyamoto, Ryuichiro Iwasaki, Hideomi Tomida, Kenichiro Mori, Hideki Miyata, Eiji Tsubouchi, Masato Kishida, Masashi Hirooka, Masanori Abe, Bunzo Matsuura, Tomoyuki Ninomiya, Izumi Mori, Yoichi Hiasa, Kojiro Michitaka
BACKGROUND/AIM: We investigated the prognostic impact of muscle volume loss (MVL) and function decline in patients undergoing resection for hepatocellular carcinoma (HCC). MATERIAL/METHODS: We enrolled 171 naïve HCC patients treated with resection from 2007 to 2015, after excluding those lacking spirometry or CT findings, who had received non-curative treatments, or with restrictive or obstructive lung disorders. The median peak expiratory flow rate (%PEF) was set as the cut-off value for muscle function decline and MVL was diagnosed using a previously reported value...
November 28, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29179632/prediction-of-the-ablated-area-prior-to-radiofrequency-ablation-for-liver-tumor-under-ct-guidance
#16
Rika Yoshimatsu, Akinori Doi, Tomoaki Yamanishi, Miki Nishimori, Kenta Ogi, Kenji Kajiwara, Taiji Tamura, Hiroki Minamiguchi, Takuji Yamagami
PURPOSE: To evaluate the usefulness of a method we developed to predict the ablation area at the time of CT guided radiofrequency (RF) ablation for liver tumors on a CT workstation. MATERIAL AND METHODS: Ten tumors (mean diameter 15.5 mm, range, 9.0-21.5 mm) in seven patients with hepatocellular carcinoma for which CT guided RF ablation was performed were subjects of this study. After advancing the electrode, plain CT was obtained. Then a simulated ball to predict the ablated area was created on the workstation...
November 27, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/29172243/characterization-of-90y-spect-ct-self-calibration-approaches-on-the-quantification-of-voxel-level-absorbed-doses-following-90y-microsphere-selective-internal-radiation-therapy
#17
Anjali Balagopal, Cheenu Kappadath
PURPOSE: 90Y-microsphere selective internal radiation therapy (90Y-SIRT or 90Y-radioembolization) is used in the management of unresectable liver tumors. 90Y-SIRT presents a unique situation where the total 90Y activity inside the liver can be determined with high accuracy (>95%). 90Y bremsstrahlung single-photon emission computed tomography (SPECT)/computed tomography (CT) can be self-calibrated to provide quantitative images that facilitate voxel-level absorbed dose calculations...
November 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/29168007/can-dual-energy-ct-replace-perfusion-ct-for-the-functional-evaluation-of-advanced-hepatocellular-carcinoma
#18
Sébastien Mulé, Frédéric Pigneur, Ronan Quelever, Arthur Tenenhaus, Laurence Baranes, Philippe Richard, Vania Tacher, Edouard Herin, Hugo Pasquier, Maxime Ronot, Alain Rahmouni, Valérie Vilgrain, Alain Luciani
OBJECTIVES: To determine the degree of relationship between iodine concentrations derived from dual-energy CT (DECT) and perfusion CT parameters in patients with advanced HCC under treatment. METHODS: In this single-centre IRB approved study, 16 patients with advanced HCC treated with sorafenib or radioembolization who underwent concurrent dynamic perfusion CT and multiphase DECT using a single source, fast kV switching DECT scanner were included. Written informed consent was obtained for all patients...
November 22, 2017: European Radiology
https://www.readbyqxmd.com/read/29167923/preoperative-prediction-of-microvascular-invasion-of-hepatocellular-carcinoma-using-18-f-fdg-pet-ct-a-multicenter-retrospective-cohort-study
#19
Seung Hyup Hyun, Jae Seon Eo, Bong-Il Song, Jeong Won Lee, Sae Jung Na, Il Ki Hong, Jin Kyoung Oh, Yong An Chung, Tae-Sung Kim, Mijin Yun
PURPOSE: The aim of this study was to assess the potential of tumor (18)F-fluorodeoxyglucose (FDG) avidity as a preoperative imaging biomarker for the prediction of microvascular invasion (MVI) of hepatocellular carcinoma (HCC). METHODS: One hundred and fifty-eight patients diagnosed with Barcelona Clinic Liver Cancer stages 0 or A HCC (median age, 57 years; interquartile range, 50-64 years) who underwent (18)F-FDG positron emission tomography with computed tomography (PET/CT) before curative surgery at seven university hospitals were included...
November 22, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29166754/advances-in-oncological-treatment-limitations-of-recist-1-1-criteria
#20
Serena Grimaldi, Marie Terroir, Caroline Caramella
INTRODUCTION: RECIST 1.1 criteria are the standard for the response assessment of most solid tumors on computed tomography (CT). Nevertheless, the emergence of new classes of treatment in the lasts decades has brought new challenges in the response evaluation. EVIDENCE ACQUISITION: A PubMed online database literature search was performed in order to identify papers in English with full text available published up to September 2017. EVIDENCE SYNTHESIS: Some oncologic treatments, such as anti-angiogenic agents, immunotherapy and local treatments, have proven to be effective despite atypical patterns of responses...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
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