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Hepatocellular carcinoma, CT

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https://www.readbyqxmd.com/read/29781162/predictors-of-ultrasound-failure-to-detect-hepatocellular-carcinoma
#1
Mariya L Samoylova, Neil Mehta, John P Roberts, Francis Y Yao
Current guidelines recommend ultrasound (US) for hepatocellular carcinoma (HCC) surveillance in cirrhosis. We assess predictors of decreased US sensitivity for detecting HCC. At a single U.S. center, all HCC patients evaluated for liver transplant (LT) receive an abdominal US. In consecutive patients presenting 2007-2015, untreated lesions found on CT/MRI within 3 months of US were compared with US findings. Multivariable logistic regression models compared US sensitivities by patient characteristics. Of 1008 patients completing LT evaluation, 47...
May 21, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29775121/a-cohort-study-to-examine-the-use-of-chinese-herbal-medicine-in-combination-with-conventional-therapies-for-patients-with-hepatocellular-carcinoma-in-china
#2
Lingling Sun, Paul Fahey, Xiaoshu Zhu, Weng Ng, Zhuo Ping Chen, Yiwen Qiu, Hezheng Lai, Jietao Lin, Lizhu Lin
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the major malignancies associated with high mortality rates. Chinese herbal medicine (CHM) alone, or in combination with conventional therapies (CT), has been widely used for patients with HCC in China. This study aims to explore how integrative therapy (IT) through the combination of CHM and CT affects the survival of patients with intermediate-advanced HCC. METHODS: A retrospective cohort study was performed at the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China...
May 1, 2018: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29774382/iodine-material-density-images-in-dual-energy-ct-quantification-of-contrast-uptake-and-washout-in-hcc
#3
Daniela Pfeiffer, Anushri Parakh, Manuel Patino, Avinash Kambadakone, Ernst J Rummeny, Dushyant V Sahani
PURPOSE: To determine the diagnostic potential of Material Density (MD) iodine images in dual-energy CT (DECT) for visualization and quantification of arterial phase hyperenhancement and washout in hepatocellular carcinomas compared to magnetic resonance imaging (MRI). MATERIALS AND METHODS: The study complied with HIPAA guidelines and was approved by the ethics committee of the institutional review board. Thirty-one patients (23 men, 8 women; age range, 36-87 years) with known or suspected Hepatocellular Carcinoma (HCC) were included...
May 17, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29758936/evaluation-of-integrated-color-coded-perfusion-analysis-for-contrast-enhanced-ultrasound-ceus-after-percutaneous-interventions-for-malignant-liver-lesions-first-results
#4
I Wiesinger, L P Beyer, N Zausig, N Verloh, P Wiggermann, C Stroszczynski, E M Jung
BACKGROUND:  With the rising number of percutaneous ablation therapies in malignant liver lesions there is a need of reliable diagnostics after the intervention to differentiate between reactive changes and tumor. PURPOSE: To assess the success of percutaneous ablation therapies for malignant liver lesions using CEUS with perfusion analysis. MATERIAL AND METHODS: Retrospective analysis of perfusion analysis for 67 patients with 94 malignant liver lesions, treated with ablation therapies...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29758561/surgical-outcome-and-hepatic-regeneration-after-hepatic-resection-for-hepatocellular-carcinoma-in-elderly-patients
#5
Yoshihiro Inoue, Ryo Tanaka, Kensuke Fujii, Nao Kawaguchi, Masatsugu Ishii, Shinsuke Masubuchi, Masashi Yamamoto, Fumitoshi Hirokawa, Michihiro Hayashi, Kazuhisa Uchiyama
INTRODUCTION: The rising proportion of elderly patients (aged 80 yearsor above) in our population means that more elderly patients are undergoing hepatectomy. METHODS: Five-hundred and thirty patients who underwent hepatectomy for hepatocellular carcinoma (HCC) were retrospectively analyzed with respect to their preoperative status and perioperative results, including remnant liver regeneration. The remnant liver volume was postoperatively measured with multidetector CT on postoperative day 7 and 1, 2, 5, and 12 months after surgery...
May 14, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29753174/skeletal-muscle-fat-deposition-is-associated-with-hepatocellular-carcinoma-development-in-patients-with-chronic-liver-disease
#6
Yoshihiko Tachi, Akihiro Kozuka, Takanori Hirai, Yuko Kojima, Yoji Ishizu, Takashi Honda, Teiji Kuzuya, Kazuhiko Hayashi, Masatoshi Ishigami, Hidemi Goto
OBJECTIVES: The effect of skeletal muscle fat deposition on the prognosis of patients with chronic liver disease remains unclear. Skeletal muscle fat deposition can be estimated by attenuation of skeletal muscle in Hounsfield units (HU) on computed tomography (CT). The aim of this retrospective cohort study was to investigate the association between skeletal muscle fat deposition assessed by skeletal muscle attenuation (SMA), and hepatocellular carcinoma (HCC). METHODS: We enrolled 288 patients with chronic liver disease (139 men, 149 women; mean age 67...
March 21, 2018: Nutrition
https://www.readbyqxmd.com/read/29745518/-research-and-application-of-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-for-the-diagnosis-and-treatment-of-primary-hepatocellular-carcinoma
#7
REVIEW
Wei Wang, Jinhui You
Primary hepatocellular carcinoma is a common cancer. Many patients are found with intermediate-advanced stage, rapid development, poor treatment and high mortality. 18 F-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) can discover the early lesions and therefore plays an important role in diagnosis, treatment and prognosis of patients with hepatocellular carcinoma. It especially has obvious advantages in detecting metastasis and monitoring recurrence. However, 18 F-FDG PET/CT imaging has poor quality and low diagnosis rate...
June 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29741398/cxcl12-and-cxcr4-polymorphisms-and-expressions-in-peripheral-blood-from-patients-of-hepatocellular-carcinoma
#8
Li-Feng Qin, Jin-Mei Qin, Ji-Qiao Zhang, Xiao-Ping Lv, Li-Yi Huang, Jing-Jing Wang
AIM: To determine if CXCL12 (rs1801157) and CXCR4 (rs2228014) polymorphisms are associated with hepatocellular carcinoma (HCC) susceptibility, and detect their expressions in peripheral blood. METHODS: 206 HCC patients, 252 chronic hepatitis B patients, 221 liver cirrhosis patients and 275 healthy volunteers were recruited. Genes CXCL12 and CXCR4 were amplified and genotyped. Their expression in peripheral blood were detected. RESULTS: CXCL12 rs1801157 and CXCR4 rs2228014 polymorphisms were associated with increased susceptibility of HCC, and genotypes GA/AA and CT/TT may be risk factors of HCC (all p < 0...
May 9, 2018: Future Oncology
https://www.readbyqxmd.com/read/29734449/-contrast-enhanced-ultrasound-liver-imaging-reporting-and-data-system-ceus-li-rads
#9
Christoph F Dietrich, Andrej Potthoff, Thomas Helmberger, Andre Ignee, Juergen K Willmann
The American College of Radiology (ACR) endorsed the Liver Imaging Reporting and Data System (LI-RADS) for standardized reporting and data collection of computed tomography (CT) and magnetic resonance (MR) imaging for hepatocellular carcinoma (HCC) in high-risk patients (liver cirrhosis). The LI-RADS imaging criteria are used to classify 'observations' from 'definitely benign' (LR-1) to 'definitely HCC' (LR-5) based on imaging criteria.Coincidently, the recent approval in the United States of a microbubble contrast agent for liver imaging (Lumason® , known as SonoVue® in Europe and elsewhere), LI-RADS...
May 2018: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29730738/short-term-reproducibility-of-radiomic-features-in-liver-parenchyma-and-liver-malignancies-on-contrast-enhanced-ct-imaging
#10
Thomas Perrin, Abhishek Midya, Rikiya Yamashita, Jayasree Chakraborty, Tome Saidon, William R Jarnagin, Mithat Gonen, Amber L Simpson, Richard K G Do
PURPOSE: To evaluate the short-term reproducibility of radiomic features in liver parenchyma and liver cancers in patients who underwent consecutive contrast-enhanced CT (CECT) with intravenous iodinated contrast within 2 weeks by chance. METHODS: The Institutional Review Board approved this HIPAA-compliant retrospective study and waived the requirement for patients' informed consent. Patients were included if they had a liver malignancy (liver metastasis, n = 22, intrahepatic cholangiocarcinoma, n = 10, and hepatocellular carcinoma, n = 6), had two consecutive CECT within 14 days, and had no prior or intervening therapy...
May 5, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29728899/stereotactically-navigated-percutaneous-microwave-ablation-mwa-compared-to-conventional-mwa-a-matched-pair-analysis
#11
L P Beyer, L Lürken, N Verloh, M Haimerl, K Michalik, J Schaible, C Stroszczynski, P Wiggermann
PURPOSE: To compare CT-navigated stereotactic microwave ablation (SMWA) to non-navigated conventional MWA (CMWA) for percutaneous ablation of liver malignancies. METHODS: A matched pair analysis of 36 patients who underwent MWA of primary or secondary liver malignancies (10 hepatocellular carcinoma and 8 metastases) was conducted. A total of 18 patients undergoing SMWA were included in this prospective study. Patients were matched in terms of tumor size, liver segment and entity to retrospective CMWA procedures...
May 4, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29725257/impact-of-matrix-metalloproteinase-11-gene-polymorphisms-upon-the-development-and-progression-of-hepatocellular-carcinoma
#12
Bin Wang, Chin-Jung Hsu, Hsiang-Lin Lee, Chia-Hsuan Chou, Chen-Ming Su, Shun-Fa Yang, Chih-Hsin Tang
Hepatocellular carcinoma (HCC) is a liver malignancy and a major cause of cancer mortality worldwide. Matrix metalloproteinase-11 (MMP-11), also known as stromelysin-3, plays a critical role during tumor migration, invasion and metastasis. Here, we report on the association between five single nucleotide polymorphisms (SNPs) - rs738791, rs2267029, rs738792, rs28382575, and rs131451 - of the MMP-11 gene and HCC susceptibility, as well as clinical outcomes, in 293 patients with HCC and in 586 cancer-free controls...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29724521/chemoembolization-of-hepatocellular-carcinoma-with-drug-eluting-polyethylene-glycol-embolic-agents-single-center-retrospective-analysis-in-302-patients
#13
Filipe Veloso Gomes, João A Oliveira, Mariana Tomé Correia, Nuno Vasco Costa, João Abrantes, Daniel Torres, Pedro Pereira, Ana Isabel Ferreira, José Hugo Luz, Erik Spaepen, Tiago Bilhim, Élia Coimbra
PURPOSE: To evaluate the efficacy and safety of transarterial chemoembolization with polyethylene glycol (PEG) drug-eluting embolic agents in the treatment of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: A single-center retrospective study of 302 patients (258 men; 85.4%) with HCC treated during a 20-month period was conducted. The mean patient age was 66 years ± 10; 142 (47%) had Barcelona Clinic Liver Cancer stage A disease and 134 had (44.4%) stage B disease; 174 (57...
April 30, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29719484/a-case-of-well-differentiated-hepatocellular-carcinoma-identified-on-gallium-68-prostate-specific-membrane-antigen-positron-emission-tomography-computed-tomography
#14
Hian Liang Huang, Tracy Jie Zhen Loh, Pierce Kah Hoe Chow
Prostate-specific membrane antigen (PSMA) is a glycosylated type-II transmembrane protein highly expressed in certain tumor cells. To the best of our knowledge, this is the first case reported of an isolated well-differentiated hepatocellular carcinoma (HCC) strongly suspected on gallium-68 (68 Ga)-PSMA positron emission tomography/computed tomography (PET/CT), which was not well characterized both on magnetic resonance imaging (MRI) liver with Primovist as well as fluorine-18 (18 F)-choline PET/CT. Our patient had previous prostate cancer and previously was imaged using 18 F-choline PET/CT...
April 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29715132/synchronous-pancreatic-ductal-adenocarcinoma-and-hepatocellular-carcinoma-report-of-a-case-and-review-of-the-literature
#15
Jenny Z Lai, Yihua Zhou, Dengfeng Cao
Two or more histologically distinct malignancies diagnosed during the same hospital admission are uncommon, but they do exist. Cases with synchronous primary pancreatic ductal adenocarcinoma and hepatocellular carcinoma are rarely seen. This is a case report of a 56 years old Caucasian female with the chief complaint of jaundice over a duration of 10 days. CT imaging findings revealed a 3.5 cm ill-defined pancreatic head mass and a 1.5 cm liver mass in the segment 5. EUS-FNA cytology showed pancreatic head ductal adenocarcinoma (PDAC)...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29708786/differentiation-between-hepatocellular-carcinoma-showing-hyperintensity-on-the-hepatobiliary-phase-of-gadoxetic-acid-enhanced-mri-and-focal-nodular-hyperplasia-by-ct-and-mri
#16
Azusa Kitao, Osamu Matsui, Norihide Yoneda, Ryuichi Kita, Kazuto Kozaka, Satoshi Kobayashi, Toshifumi Gabata
OBJECTIVE: The purpose of this study is to identify points useful in the imaging differentiation of hepatocellular carcinoma (HCC) showing hyperintensity on the hepatobiliary phase of gadoxetic acid-enhanced MRI and focal nodular hyperplasia (FNH) and FNH-like nodules. MATERIALS AND METHODS: We enrolled consecutive 51 pathologically diagnosed HCCs that were hyperintense on hepatobiliary phase imaging (47 patients, including 44 with cirrhosis) and 10 FNHs and eight FNH-like nodules (16 patients, including five with cirrhosis)...
April 30, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29708329/imaging-tiny-hepatic-tumor-xenografts-via-endoglin-targeted-paramagnetic-optical-nanoprobe
#17
Huihui Yan, Xihui Gao, Yunfei Zhang, Wenju Chang, Jianhui Li, Xinwei Li, Qin Du, Cong Li
Surgery is a mainstay for treating hepatocellular carcinoma (HCC). However, it is a great challenge for surgeons to identify HCC in its early developmental stage. The diagnostic sensitivity for tiny HCC with a diameter less than 1.0 cm is usually as low as 10-33% for computed tomography (CT) and 29-43% for magnetic resonance imaging (MRI). Although MRI is the preferred imaging modality for detecting HCC, with its unparalleled spatial resolution for soft tissue, the commercially available contrast agents, such as Gd3+ -DTPA, cannot accurately define HCC due to its short circulation lifetime and lack of tumor targeting specificity...
April 30, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29692186/outcome-of-indeterminate-liver-lesions-on-computed-tomography-in-patients-with-colorectal-cancer
#18
E Mohamed, A Adiamah, W K Dunn, Y Higashi, I C Cameron, D Gomez
Introduction The aim of this study was to determinate the outcome of indeterminate liver lesions on computed tomography (CT) in patients with a background history of colorectal cancer (CRC) and to identify clinicopathological variables associated with malignancy in these lesions. A secondary aim was to devise a management algorithm for such patients. Methods Patients referred to our institution with indeterminate liver lesions on CT with a background history of CRC between January 2012 and December 2014 were included in the study...
April 25, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29690933/li-rads-v2017-for-liver-nodules-how-we-read-and-report
#19
REVIEW
Wolfgang Schima, Jay Heiken
The Liver Imaging Reporting and Data System (LI-RADS) standardizes the interpretation and reporting of imaging examinations in patients at risk for hepatocellular carcinoma (HCC). For focal liver observations it assigns categories (LR-1 to 5, LR-M, LR-TIV), which reflect the relative probability of benignity or malignancy of the respective observation. The categories assigned are based on major and ancillary image features, which have been developed by the American College of Radiology (ACR) and validated in many studies...
April 24, 2018: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/29680967/parametric-response-mapping-cut-off-values-that-predict-survival-of-hepatocellular-carcinoma-patients-after-tace
#20
REVIEW
Aventinus Nörthen, Thomas Asendorf, Hoen-Oh Shin, Jan B Hinrichs, Thomas Werncke, Arndt Vogel, Martha M Kirstein, Frank K Wacker, Thomas Rodt
PURPOSE: Parametric response mapping (PRM) is a novel image-analysis technique applicable to assess tumor viability and predict intrahepatic recurrence of hepatocellular carcinoma (HCC) patients treated with transarterial chemoembolization (TACE). However, to date, the prognostic value of PRM for prediction of overall survival in HCC patients undergoing TACE is unclear. The objective of this explorative, single-center study was to identify cut-off values for voxel-specific PRM parameters that predict the post TACE overall survival in HCC patients...
April 21, 2018: Abdominal Radiology
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