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Hepatocellular carcinoma, CT

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https://www.readbyqxmd.com/read/27899780/-a-case-of-successful-drug-eluting-microsphere-transcatheter-arterial-embolization-for-hepatocellular-carcinoma-with-associated-tumor-thrombus-in-the-inferior-vena-cava-and-right-atrium
#1
Katsuya Takechi, Shinichi Hori, Keita Yamashiro, Takeo Yuki, Atsushi Hori
Hepatocellular carcinoma(HCC)with severe vascular invasion has a dismal prognosis, and there is no well-established effective therapy. We report an 84-year-old man who benefited from multiple transcatheter arterial chemoembolization (TACE)treatments for advanced HCC with severe vascular invasion. Initial CT revealed a recurrent, poorly differentiated HCC with tumor thrombus in the inferior vena cava(IVC)and right atrium(Vv3). Two cycles of TACE with 5-FU, DOC, MMC, and superabsorbent polymer microspheres(SAP-MS)with BV resulted in considerable reduction of the tumor thrombus...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27897079/copper-ii-cobalt-ii-and-nickel-ii-complexes-of-lapachol-synthesis-dna-interaction-and-cytotoxicity
#2
Leila Tabrizi, Faranak Talaie, Hossein Chiniforoshan
Three novel copper(II), cobalt(II), and nickel(II) complexes of lapachol (Lap) containing 1,10-phenanthroline (phen) ligand, [M(Lap)2(phen)] (M = Cu(II), 1, Co(II), 2, and Ni(II), 3), have been synthesized and characterized using, elemental analysis and spectroscopic studies. Their interactions with calf thymus DNA (CT DNA) were investigated using viscosity, thermal denaturation, circular dichorism, fluorescence quenching, and electronic absorption spectroscopy. The DNA cleavage abilities of 1-3 have been studied, which cleavage activity of copper complex 1 is more than the complexes 2 and 3...
November 29, 2016: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/27895412/metabolic-imaging-for-guidance-of-curative-treatment-of-isolated-pelvic-implantation-metastasis-after-resection-of-spontaneously-ruptured-hepatocellular-carcinoma-a-case-report
#3
Bing Hao, Wei Guo, Na-Na Luo, Hao Fu, Hao-Jun Chen, Long Zhao, Hua Wu, Long Sun
Spontaneous rupture of hepatocellular carcinoma (HCC) is a life-threatening complication and its prognosis is significantly poor because of the high recurrence rate after initial hepatectomy. Resection of isolated extrahepatic metastasis of HCC has been advocated to obtain a possibility of long-term survival. However, it is a challenge for clinicians to detect implantation metastasis of spontaneously ruptured HCC. Accurate re-staging plays the most important role in making a decision on isolated metastasis resection...
November 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27895410/collision-tumor-of-hepatocellular-carcinoma-and-neuroendocrine-carcinoma-involving-the-liver-case-report-and-review-of-the-literature
#4
Gyu Ho Choi, Sun Young Ann, Soon Il Lee, Suk Bae Kim, Il Han Song
Primary hepatic neuroendocrine carcinoma (NEC) with concurrent occurrence of hepatocellular carcinoma (HCC) of the liver is very rare. Only 8 cases have been reported in the literature. Concurrent occurrence of HCC and NEC in the liver is classified as combined type or collision type by histological distributional patterns; only 2 cases have been reported. Herein, we report a case of collision type concurrent occurrence of HCC and NEC, in which primary hepatic NEC was in only a small portion of the nodule, which is different from the 2 previously reported cases...
November 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27893681/combination-of-transcatheter-arterial-chemoembolization-and-ct-guided-percutaneous-segment-ablation-for-hepatocellular-carcinoma-therapy-a-retrospective-study
#5
Wei Li, Yang Wang, Wenfeng Gao, Jiasheng Zheng
Treatment option for liver cancer patients with large tumor >5 cm and/or portal vein tumor thrombosis is very limited. New treatment strategy is badly needed. Our study is to determine the safety and treatment efficacy of a new minimally invasive treatment strategy-liver segment thermal ablation.Late-stage hepatocellular carcinoma patients were included and treated with percutaneous ablation to destroy the entire tumor-containing liver segment to reduce reoccurrence and prolong survival. Transcatheter arterial chemoembolization was used before ablation to label tumor margin...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27890423/hepatic-epithelioid-angiomyolipoma-clinical-features-and-imaging-findings-of-contrast-enhanced-ultrasound-and-ct
#6
Y Tan, X Xie, Y Lin, T Huang, G Huang
AIM: To evaluate the clinical features and imaging findings of epithelioid angiomyolipoma (EAML) on contrast-enhanced ultrasound (CEUS) and contrast-enhanced computed tomography (CECT). MATERIALS AND METHODS: During January 2006 to November 2015, six patients with histopathologically proven hepatic EAML were evaluated using both CECT and ultrasonography. Six patients underwent CEUS and four patients had CECT images. Patients' demographics, clinical presentations, laboratory test results, and imaging appearances were collected and analysed...
November 24, 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27890422/treatment-efficacy-of-ct-guided-percutaneous-microwave-ablation-for-primary-hepatocellular-carcinoma
#7
T Yin, W Li, P Zhao, Y Wang, J Zheng
AIM: To evaluate the treatment efficacy and potential complications of computed tomography (CT)-guided microwave ablation for primary hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Data were collected and analysed from 220 HCC patients treated with CT-guided microwave ablation and followed up for 2 years. Independent risk factors for overall survival and progression-free survival (PFS) were analysed. RESULTS: Among all cases followed, the cumulative overall survival rates at 1 and 2 years were 95...
November 25, 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27882419/pleural-effusion-after-hepatectomy-for-hepatocellular-carcinoma-risk-factor-analyses-and-its-impact-on-oncological-outcomes
#8
Hideaki Uchiyama, Norifumi Harimoto, Shinji Itoh, Tomoharu Yoshizumi, Toru Ikegami, Yoshihiko Maehara
BACKGROUND: Although posthepatectomy pleural effusion (PHPE) is a commonly observed phenomenon, its precise etiology and the impact of its emergence on oncological outcomes have still unknown. The aim of the current study was to retrospectively investigate risk factors for PHPE and its impact on oncological outcomes of hepatocellular carcinoma (HCC). METHODS: Medical records of 330 patients who underwent primary curative hepatectomy for HCC were reviewed. All 330 patients had CT around day 7 after hepatectomy, and the emergence of PHPE on CT was examined...
November 23, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27878570/synchronous-double-cancers-of-primary-hepatocellular-carcinoma-and-cholangiolocellular-carcinoma-a-case-report
#9
Kazuhiro Suzumura, Yasukane Asano, Tadamichi Hirano, Toshihiro Okada, Naoki Uyama, Nobuhiro Aizawa, Hiroko Iijima, Keiji Nakasho, Shuhei Nishiguchi, Jiro Fujimoto
Synchronous double cancers consisting of hepatocellular carcinoma (HCC) and cholangiolocellular carcinoma (CoCC) are extremely rare. We herein report a surgical case of synchronous double cancers in a patient with primary HCC and CoCC. A 45-year-old man with hepatitis B was admitted to our hospital with hepatic tumors. The level of protein induced by vitamin K antagonist (PIVKA-II) was found to be elevated. Computed tomography (CT) revealed a 23-mm tumor with early-phase enhancement and late-phase washout in the 6th segment of the liver, and a 10-mm tumor with slight early-phase enhancement and late-phase washout in the 7th segment of the liver...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27867167/evaluation-of-fat-quantification-in-the-liver-using-dual-energy-ct
#10
Shunsuke Itaya, Takeshi Matsui, Tetsuya Kamiyama, Hiroyuki Yoshino
BACKGROUND AND PURPOSE: Recently, the number of patients with nonalcoholic fatty liver disease (NAFLD) has been increasing, and some of them progresses to cirrhosis and hepatocellular carcinoma. Dual energy CT allows the discrimination of substance using monochromatic image (MI), and steatosis exhibit specifically the CT value of each energy level. The purpose is to evaluate the fat quantification in the liver using spectral HU curve and CT value compare to a conventional image diagnosis...
2016: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/27862748/-potential-of-a-no-touch-pincer-ablation-procedure-that-uses-a-multipolar-radiofrequency-ablation-system-to-prevent-intra-subsegmental-recurrence-of-small-and-single-hepatocellular-carcinomas
#11
Yusuke Kawamura, Kenji Ikeda, Shunichiro Fujiyama, Tetsuya Hosaka, Masahiro Kobayashi, Satoshi Saitoh, Hitomi Sezaki, Norio Akuta, Fumitaka Suzuki, Yoshiyuki Suzuki, Yasuji Arase, Hiromitsu Kumada
OBJECTIVE: The aim of this study was to clarify the usefulness of a no-touch pincer ablation procedure that uses bipolar electrodes to prevent intra-subsegmental tumor recurrence after radiofrequency ablation (RFA) for patients with hepatocellular carcinoma (HCC). METHODS: We studied 303 consecutive patients with HCC (single nodule and tumor diameter of ≤30 mm) who received RFA between January 2005 and April 2015; 268 patients received touch ablation using a monopolar or bipolar RFA device, and 35 received no-touch ablation using a bipolar RFA device...
November 15, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/27859840/value-of-mr-elastography-for-the-preoperative-estimation-of-liver-regeneration-capacity-in-patients-with-hepatocellular-carcinoma
#12
Siwon Jang, Jeong Min Lee, Dong Ho Lee, Ijin Joo, Jeong Hee Yoon, Won Chang, Joon Koo Han
PURPOSE: To demonstrate the negative relationship between liver stiffness (LS) values measured at preoperative magnetic resonance elastography (MRE) and the regeneration capacity of the remnant liver after major hepatectomy, in patients with hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Thirty-eight patients with HCC (mean age, 57.1) who had undergone liver computed tomography (CT) and 1.5T MRE prior to right hepatectomy were included in this retrospective study...
November 16, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27829060/comprehensive-comparison-of-multiple-detector-computed-tomography-and-dynamic-magnetic-resonance-imaging-in-the-diagnosis-of-hepatocellular-carcinoma-with-varying-degrees-of-fibrosis
#13
Ming-Tsung Lin, Chih-Chi Wang, Yu-Fan Cheng, Hock-Liew Eng, Yi-Hao Yen, Ming-Chao Tsai, Po-Lin Tseng, Kuo-Chin Chang, Cheng-Kun Wu, Tsung-Hui Hu
BACKGROUND & AIMS: Liver computed tomography and dynamic magnetic resonance imaging play an important role in the early detection of hepatocellular carcinoma. However, the American Association for the Study of Liver Diseases (AASLD) recommend the use of applied imaging studies for HCC diagnosis only in cirrhotic patients. This study aimed to comprehensively compare liver CT and dynamic MRI for HCC diagnosis before surgical resection over years in clinical practice, and also to compare the diagnostic differences between liver CT and dynamic MRI in HCCs with varying degrees of fibrosis...
2016: PloS One
https://www.readbyqxmd.com/read/27826555/role-of-positron-emission-tomography-computed-tomography-in-living-donor-liver-transplantation-for-hepatocellular-carcinoma
#14
REVIEW
Seung Duk Lee, Seong Hoon Kim
Living donor liver transplantation (LDLT) becomes an important option for treatment for patients with hepatocellular carcinoma (HCC). With the advance of imaging modalities such as computed tomography (CT) and magnetic resonance image (MRI), preoperative staging and diagnosis for HCC was improved in LDLT. However, morphological characteristics based on the tumor number and size do not represent the tumor pathology and prognosis clearly. Therefore, many criteria using various markers have been reported, but still have limitation to predict the pathology and prognosis...
October 2016: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/27818006/phase-contrast-ct-qualitative-and-quantitative-evaluation-of-capillarized-sinusoids-and-trabecular-structure-in-human-hepatocellular-carcinoma-tissues
#15
Jianbo Jian, Wenxue Zhang, Hao Yang, Xinyan Zhao, Ruijiao Xuan, Dongyue Li, Chunhong Hu
RATIONALE AND OBJECTIVES: Capillarization of sinusoids and change of trabecular thickness are the main histologic features in hepatocellular carcinoma (HCC). Of particular interest are the three-dimensional (3D) visualization and quantitative evaluation of such alterations in the HCC progression. X-ray phase-contrast computed tomography (PCCT) is an emerging imaging method that provides excellent image contrast for soft tissues. This study aimed to explore the potential of in-line PCCT in microstructure imaging of capillarized sinusoids and trabecular structure in human HCC tissues and to quantitatively evaluate the alterations of those fine structures during the development of HCC...
November 3, 2016: Academic Radiology
https://www.readbyqxmd.com/read/27817860/-implementation-of-a-nurse-driven-educational-program-improves-management-of-sorafenib-s-toxicities-in-hepatocellular-carcinoma
#16
Angélique Brunot, Amel M'Sadek, Florence Le Roy, Marielle Duval, Samuel Le Sourd, Elodie Ventroux, Laurence Crouzet, Anne Guillygomarc'h, Eveline Boucher, Nadine Lelievre, Brigitte Laguerre, Julien Edeline
BACKGROUND: Sorafenib is the standard treatment for advanced hepatocellular carcinoma (HCC). Due to its peculiar toxicities, improving patient's tolerance may need close follow-up. Nurses can play a crucial role, by driving a patient education program (EP). We aimed to prove that adding EP to usual care (UC) improves patient's care. METHODS: Since 2011, oncologists referred patients treated by sorafenib to the EP, driven by clinical nurses. It consisted in a visit before first administration, weekly telephone calls and a visit before each oncologist consultation...
November 3, 2016: Bulletin du Cancer
https://www.readbyqxmd.com/read/27816969/anti-metastatic-effect-of-the-tm4sf5-specific-peptide-vaccine-and-humanized-monoclonal-antibody-on-colon-cancer-in-a-mouse-lung-metastasis-model
#17
Guang Wu, Dongbum Kim, Byoung Kwon Park, Sangkyu Park, Ji-Hee Ha, Te Ha Kim, Avishekh Gautam, Jung Nam Kim, Su In Lee, Han-Bum Park, Yong-Sung Kim, Hyung-Joo Kwon, Younghee Lee
Transmembrane 4 superfamily member 5 protein (TM4SF5) is a potential therapeutic target for hepatocellular carcinoma (HCC) and colon cancer. In a previous study, we demonstrated the prophylactic and therapeutic effects of a TM4SF5-specific peptide vaccine and monoclonal antibody in HCC and colon cancer in a mouse model. Here, we designed a cyclic peptide targeting TM4SF5. Cyclic peptide-specific antibodies were produced in mice after immunization with a complex of the peptide, CpG-DNA, and liposomes. Intravenous injection of the CT-26 mouse colon cancer cell line into mice induced tumors in the lung...
November 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27814341/association-between-microrna-125a-rs12976445-c-t-polymorphism-and-18f-fluorodeoxyglucose-18fdg-uptake-clinical-and-metabolic-response-in-patients-with-non-small-cell-lung-cancer
#18
Zhina Zang, Wenhua Guan, Diansen Chen, Yan Han, Zhan Shi, Jinjin Zhou
BACKGROUND MicroRNA-125a (miR-125a) has been involved with many diseases, such as hepatocellular carcinoma and inflammation. In this study, we aimed to investigate the molecular mechanism, including the potential regulator and signaling pathways, of vascular endothelial growth factor (VEGF). MATERIAL AND METHODS We divided the participants into 3 groups by rs12976445 genotype and performed chi-square tests to evaluate the differences between CC and CT+TT groups for sex, age, grading, pT category, metastases, and fludeoxyglucose F18 injection (18FDG) metabolism...
November 4, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27801695/early-response-of-hepatocellular-carcinoma-to-chemoembolization-volume-computed-tomography-liver-perfusion-imaging-as-a-short-term-response-predictor
#19
Tian-Hao Su, Wen He, Long Jin, Guang Chen, Guo-Wen Xiao
OBJECTIVE: The aim of this study was to investigate the efficacy of lesion-oriented whole-liver computed tomography (CT) perfusion for predicting transarterial chemoembolization early treatment response in patients with hepatocellular carcinoma (HCC). METHODS: Volume helical shuttle CT perfusion imaging on the whole liver was prospectively performed on 39 patients with 46 independent HCC lesions before target-selected chemoembolization. The therapeutic effects were assessed: responder group included lesions with a complete and partial response, whereas the nonresponder group contained stable and progressive disease...
October 31, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27801693/change-in-liver-imaging-reporting-and-data-system-characterization-of-focal-liver-lesions-using-gadoxetate-disodium-magnetic-resonance-imaging-compared-with-contrast-enhanced-computed-tomography
#20
Thomas A Hope, Rizwan Aslam, Stefanie Weinstein, Benjamin M Yeh, Carlos U Corvera, Alex Monto, Judy Yee
PURPOSE: The aim of this study was to determine whether gadoxetate-enhanced magnetic resonance imaging (MRI) improves lesion characterization in patients at risk for hepatocellular carcinoma compared with computed tomography (CT). MATERIALS AND METHODS: Forty-nine patients with indeterminate lesions found at contrast-enhanced CT were prospectively enrolled and imaged using gadoxetate-enhanced hepatobiliary phase (HBP) MRI within 30 days of their initial CT. Three readers graded each lesion at CT and MRI using the Liver Imaging Reporting and Data System (LI-RADS) v2014 major criteria and HBP characterization as an ancillary feature...
October 31, 2016: Journal of Computer Assisted Tomography
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