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Hepatocellular carcinoma, CT

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https://www.readbyqxmd.com/read/29152431/intensity-modulated-proton-therapy-with-advanced-planning-techniques-in-a-challenging-hepatocellular-carcinoma-patient
#1
Smith Apisarnthanarax, Jatinder Saini, Avril O'Ryan-Blair, Jackie Castro, Stephen R Bowen
The use of radiation therapy has been increasing over recent years for the treatment of hepatocellular carcinoma (HCC). Proton beam therapy (PBT) has emerged as a promising treatment option for HCC patients due to its dosimetric advantages of sparing more normal liver tissue from radiation at low to moderate doses compared to photon-based treatments while still delivering high doses of radiation to tumors. The PBT therapy may be particularly beneficial in high-risk HCC cirrhotic patients with large, bulky tumors and/or vascular invasion complicated by surrounding perfusion abnormalities...
September 10, 2017: Curēus
https://www.readbyqxmd.com/read/29151935/comparison-of-combined-transcatheter-arterial-chemoembolization-and-ct-guided-radiofrequency-ablation-with-surgical-resection-in-patients-with-hepatocellular-carcinoma-within-the-up-to-seven-criteria-a-multicenter-case-matched-study
#2
Tao Pan, Lu-Wen Mu, Chun Wu, Xi-Qun Wu, Qian-Kun Xie, Xi-Shan Li, Ning Lyu, Shao-Long Li, Hai-Jing Deng, Zai-Bo Jiang, Ai-Hua Lin, Ming Zhao
Background & Aims: We compared the efficacy of transcatheter arterial chemoembolization (TACE) in combination with CT-guided radiofrequency ablation (RFA) with that of surgical resection (SR) in patients with hepatocellular carcinoma (HCC) within the up-to-seven criteria. Methods: From January 2004 to December 2014, 420 multicenter consecutive patients with HCC who conformed to the up-to-seven criteria and initially received either TACE plus CT-guided RFA (TACE-RFA) or SR were enrolled. A matched cohort composed of 206 patients was selected after adjustment with propensity score matching...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29140684/janus-gold-nanoplatform-for-synergetic-chemoradiotherapy-and-computed-tomography-imaging-of-hepatocellular-carcinoma
#3
Zheng Wang, Dan Shao, Zhimin Chang, Mengmeng Lu, Yingshuai Wang, Juan Yue, Dian Yang, Mingqiang Li, Qiaobing Xu, Wen-Fei Dong
There is a pressing need to develop nanoplatforms that integrate multimodal therapeutics to improve treatment responses and prolong the survival of patients with unresectable hepatocellular carcinoma (HCC). Mesoporous silica-coated gold nanomaterials have emerged as a novel multifunctional platform combining tunable surface plasmon resonance and mesoporous properties that exhibit multimodality properties in cancer theranostics. However, their reduced radiation-absorption efficiency and limited surface area hinder their further radiochemotherapeutic applications...
November 17, 2017: ACS Nano
https://www.readbyqxmd.com/read/29133822/a-non-smooth-tumor-margin-on-preoperative-imaging-assesses-microvascular-invasion-of-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#4
HangTong Hu, Qiao Zheng, Yang Huang, Xiao Wen Huang, Zhi Cheng Lai, JingYa Liu, XiaoYan Xie, Shi Ting Feng, Wei Wang, Ming De Lu
Microvascular invasion (MVI) is rarely diagnosed preoperatively in hepatocellular carcinoma (HCC). The aim of this meta-analysis is to assess the diagnostic power of a non-smooth tumor margin on preoperative imaging for MVI. We performed a literature search using the PubMed, Embase and Cochrane Library databases, and 11 studies were included involving 618 MVI-positive cases and 1030 MVI-negative cases. Considerable heterogeneity was found, and was indicated to be attributable to the mean patient ages in the included studies...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29133247/contrast-enhanced-ultrasound-identifies-hepatocellular-carcinoma-in-cirrhosis-a-large-multicenter-retrospective-study
#5
Eleonora Terzi, Massimo Iavarone, Maurizio Pompili, Letizia Veronese, Giuseppe Cabibbo, Mirella Fraquelli, Laura Riccardi, Ludovico De Bonis, Angelo Sangiovanni, Simona Leoni, Maria Assunta Zocco, Sandro Rossi, Nicola Alessi, Stephanie R Wilson, Fabio Piscaglia, Alessandro Granito, Veronica Salvatore, Francesco Tovoli, Matteo Angelo Manini, Gian Lodovico Rapaccini, Maria Elena Ainora, Valentina Ravetta, Giorgia Ghittoni, Agostino Ventra, Giuseppe Mogavero
BACKGROUND & AIMS: The use of contrast enhanced ultrasound (CEUS) for the diagnosis of hepatocellular carcinoma (HCC) in cirrhosis was questioned for the risk of false positive diagnosis in case of cholangiocarcinoma. The American College of Radiology has recently released a scheme (CEUS LI-RADS) classifying lesions at risk for HCC investigated by CEUS. Aim of the present study was to validate this LI-RADS scheme for the diagnosis of HCC. METHODS: A total of 1006 nodules in 848 patients with chronic liver disease at risk for HCC collected in 5 Italian centers were retrospectively analyzed...
November 10, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29131761/2017-version-of-li-rads-for-ct-and-mr-imaging-an-update
#6
Khaled M Elsayes, Jonathan C Hooker, Michelle M Agrons, Ania Z Kielar, An Tang, Kathryn J Fowler, Victoria Chernyak, Mustafa R Bashir, Yuko Kono, Richard K Do, Donald G Mitchell, Aya Kamaya, Elizabeth M Hecht, Claude B Sirlin
The Liver Imaging Reporting and Data System (LI-RADS) is a reporting system created for the standardized interpretation of liver imaging findings in patients who are at risk for hepatocellular carcinoma (HCC). This system was developed with the cooperative and ongoing efforts of an American College of Radiology-supported committee of diagnostic radiologists with expertise in liver imaging and valuable input from hepatobiliary surgeons, hepatologists, hepatopathologists, and interventional radiologists. In this article, the 2017 version of LI-RADS for computed tomography and magnetic resonance imaging is reviewed...
November 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29124894/combined-transcatheter-arterial-chemoembolization-and-radiofrequency-ablation-in-single-session-for-solitary-hepatocellular-carcinoma-larger-than-7%C3%A2-cm
#7
Jie-Yu Yan, Jin-Long Zhang, Mao-Qiang Wang, Kai Yuan, Yan-Hua Bai, Yan Wang, Hai-Nan Xin, Zhi-Jun Wang, Feng-Yong Liu, Feng Duan, Jin-Xin Fu
AIMS: To evaluate technical feasibility and treatment results of combined transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) in single-session for solitary hepatocellular carcinoma (HCC) larger than 7 cm in diameter. METHODS: Institutional review board approved this retrospective study. Written informed consent was obtained from all patients. Between June 2007 and July 2013, 87 patients (75 men, 12 women; mean age, 55.5 years ± 15...
November 10, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29124280/-18-f-fluorodeoxyglucose-uptake-of-hepatocellular-carcinoma-as-a-prognostic-predictor-in-patients-with-sorafenib-treatment
#8
Pil Soo Sung, Hye Lim Park, Keungmo Yang, Seawon Hwang, Myeong Jun Song, Jeong Won Jang, Jong Young Choi, Seung Kew Yoon, Ie Ryung Yoo, Si Hyun Bae
PURPOSE: Sorafenib, an oral multikinase inhibitor, is a recommended treatment option available for patients with Barcelona Clinic Liver Cancer (BCLC)-C stage hepatocellular carcinoma (HCC). This study aimed to evaluate the performance of (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) for predicting tumour progression during sorafenib treatment. METHODS: We formed a retrospective cohort comprising patients treated with sorafenib for at least 30 days and undergoing (18)F-FDG PET/CT within 1 month before treatment...
November 10, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29123005/percutaneous-ablation-for-hepatocellular-carcinoma-and-peritoneal-dialysis
#9
Annabel Boyer, Marc-Antoine Jegonday, Antoine Lanot, Maxence Ficheux, Thierry Lobbedez, Clémence Bechade
Hepatocellular carcinoma (HCC) is the second leading cause of death by cancer worldwide. Resection and liver transplantation are the gold standards, but only a minority of people are eligible. Percutaneous ablation therapies, such as microwave ablation (MWA), have consequently been developed. There is a lack of guidelines regarding the treatment of HCCs in end-stage renal disease (ESRD) patients. Here, we report the case of a 67-year-old patient who was undergoing peritoneal dialysis (PD) for chronic congestive heart failure and who presented with an HCC while undergoing PD...
November 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29112977/initial-clinical-experience-with-dual-layer-detector-spectral-ct-in-patients-with-acute-intracerebral-haemorrhage-a-single-centre-pilot-study
#10
Soo Buem Cho, Hye Jin Baek, Kyeong Hwa Ryu, Jin Il Moon, Bo Hwa Choi, Sung Eun Park, Kyungsoo Bae, Kyung Nyeo Jeon, Dong Wook Kim
PURPOSE: The purpose of this study was to investigate the clinical feasibility of spectral analyses using dual-layer detector spectral computed tomography (CT) in acute intracerebral haemorrhage (ICH). MATERIAL AND METHODS: We retrospectively reviewed patients with acute ICH who underwent CT angiography on a dual-layer detector spectral CT scanner. A spectral data analysis was performed to detect contrast enhancement in or adjacent to acute ICH by using spectral image reconstructions including monoenergetic (MonoE), virtual noncontrast (VNC), and iodine overlay fusion images...
2017: PloS One
https://www.readbyqxmd.com/read/29112010/potential-visualization-of-sorafenib-induced-acidosis-using-11c-acetate-pet-ct-in-patients-with-hepatocellular-carcinoma
#11
Seong Young Kwon, Dong-Yeon Kim, Jung-Joon Min, Woo Kyun Bae
C-acetate uptake could be increased in physiologic or inflammatory conditions without evidence of cancer. We report a hepatocellular carcinoma patient with sorafenib-induced metabolic acidosis, who showed increased hepatic uptake of C-acetate. C-acetate PET/CT might be a potentially useful surrogate marker to monitor these adverse effects via the changes in C-acetate uptake patterns from before to after drug withdrawal.
November 3, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29108379/postoperative-adjuvant-radiotherapy-is-associated-with-improved-survival-in-hepatocellular-carcinoma-with-microvascular-invasion
#12
Liming Wang, Weihu Wang, Xuesong Yao, Weiqi Rong, Fan Wu, Bo Chen, Mei Liu, Shengtao Lin, Yunhe Liu, Jianxiong Wu
Purpose: Limited studies have compared the efficacy of postoperative adjuvant therapies in HCC patients with microvascular invasion (MVI). In this study we assess the efficacy of postoperative adjuvant conservative therapy (CT), trans-catheter arterial chemoembolization (TACE) and radiotherapy (RT) in HCC patients with MVI. Results: Kaplan-Meier survival analysis revealed that patients in the RT group have significantly improved RFS (RT vs TACE: p = 0.011; RT vs CT: p < 0...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29108363/the-degree-of-hepatic-arterial-blood-supply-of-portal-vein-tumor-thrombus-in-patients-with-hepatocellular-carcinoma-and-its-impact-on-overall-survival-after-transarterial-chemoembolization
#13
Juxian Sun, Jie Shi, Bin Huang, Fantian Cheng, Weixing Guo, Wan Yee Lau, Shuqun Cheng
Purpose: To investigate the degree of arterial blood supply of portal vein tumor thrombus (PVTT) in patients with hepatocellular carcinoma (HCC), and to evaluate its impact on overall survival after transarterial chemoembolization using lipiodol +/- gelatin sponge particles (TACE). Results: Of the 10 patients who underwent surgery, the number of patients with good/mild/poor staining of PVTT by methylene blue were 3, 4, and 3, respectively. The degrees of methylene blue staining in these patients correlated well with the degrees of accumulation of lipiodol in PVTT in these patients, i...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29101980/acr-appropriateness-criteria-%C3%A2-chronic-liver%C3%A2-disease
#14
Jeanne M Horowitz, Ihab R Kamel, Hina Arif-Tiwari, Sumeet K Asrani, Nicole M Hindman, Harmeet Kaur, Michelle M McNamara, Richard B Noto, Aliya Qayyum, Tasneem Lalani
Because liver fibrosis can be treated, it is important to diagnose liver fibrosis noninvasively and monitor response to treatment. Although ultrasound (grayscale and Doppler) can diagnose cirrhosis, it does so unreliably using morphologic and sonographic features and cannot diagnose the earlier, treatable stages of hepatic fibrosis. Transient elastography, ultrasound elastography with acoustic radiation force impulse, and MR elastography are modalities that can assess for hepatic fibrosis. Although all international organizations recommend ultrasound for screening for hepatocellular carcinoma, ultrasound is particularly limited for identifying hepatocellular carcinoma in patients with obesity, nonalcoholic fatty liver disease, and nodular cirrhotic livers...
November 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29101449/clinical-indication-for-computed-tomography-during-hepatic-arteriography-ctha-in-addition-to-dynamic-ct-studies-to-identify-hypervascularity-of-hepatocellular-carcinoma
#15
Tomoyo Fuji, Yuko Nakamura, Wataru Fukumoto, Kenji Kajiwara, Keigo Chosa, Chihiro Tani, Yoshiko Matsubara, Hiroaki Terada, Yukiko Honda, Koji Arihiro, Makoto Iida, Yasutaka Baba, Kazuo Awai
PURPOSE: To identify factors benefiting from computed tomography during hepatic arteriography (CTHA) in addition to dynamic CT studies at the preoperative evaluation of the hypervascularity of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: We retrospectively divided 45 patients with HCC, who underwent both dynamic CT (dCT) and CTHA, into two groups based on the number of hypervascular HCCs identified on dCT and CTHA studies. In group A, the number of HCCs identified by dCT and CTHA was the same and additive CTHA had not been indicated...
November 3, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29100175/gallbladder-associated-symptomatic-hepatic-choristoma-should-you-resect
#16
Salah Termos, Abdullah AlDuwaisan, Mohammad Alali, Hussein Faour, Hana AlHomoud, Ahmad Alsaleh
INTRODUCTION: Hepatic choristomas or ectopic livers are uncommon, and occur due to a failure of embryological liver development. They pose a risk of carcinogenesis, with transformation to hepatocellular carcinoma (HCC) being described in the literature (Arakawa et al., 1999). It is often a silent clinical finding that can occur anywhere in the body and is usually diagnosed incidentally during abdominal surgical procedures or autopsies (Eiserth et al., 1940). We present the case of a patient with a symptomatic ectopic liver that was detected preoperatively, and removed laparoscopically with the gallbladder...
October 27, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29097935/an-individually-optimized-protocol-of-contrast-medium-injection-in-enhanced-ct-scan-for-liver-imaging
#17
Shi-Ting Feng, Hongzhang Zhu, Zhenpeng Peng, Li Huang, Zhi Dong, Ling Xu, Kun Huang, Xufeng Yang, Zhi Lin, Zi-Ping Li
Objective: To investigate the effectiveness of a new individualized contrast medium injection protocol for enhanced liver CT scan. Methods: 324 patients who underwent plain and dual phase enhanced liver CT were randomly assigned to 2 groups: G1 (n = 224, individualized contrast medium injection protocol); G2 (n = 100, standard contrast medium injection with a dose of 1.5 ml/kg). CT values and ΔHU (CT values difference between plain and enhanced CT) of liver parenchyma and tumor-liver contrast (TLC) during hepatic arterial phase (HAP) and portal venous phase (PVP) and contrast medium dose were measured...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29091751/interreader-reliability-of-li-rads-version-2014-algorithm-and-imaging-features-for-diagnosis-of-hepatocellular-carcinoma-a-large-international-multireader-study
#18
Kathryn J Fowler, An Tang, Cynthia Santillan, Mythreyi Bhargavan-Chatfield, Jay Heiken, Reena C Jha, Jeffrey Weinreb, Hero Hussain, Donald G Mitchell, Mustafa R Bashir, Eduardo A C Costa, Guilherme M Cunha, Laura Coombs, Tanya Wolfson, Anthony C Gamst, Giuseppe Brancatelli, Benjamin Yeh, Claude B Sirlin
Purpose To determine in a large multicenter multireader setting the interreader reliability of Liver Imaging Reporting and Data System (LI-RADS) version 2014 categories, the major imaging features seen with computed tomography (CT) and magnetic resonance (MR) imaging, and the potential effect of reader demographics on agreement with a preselected nonconsecutive image set. Materials and Methods Institutional review board approval was obtained, and patient consent was waived for this retrospective study. Ten image sets, comprising 38-40 unique studies (equal number of CT and MR imaging studies, uniformly distributed LI-RADS categories), were randomly allocated to readers...
November 1, 2017: Radiology
https://www.readbyqxmd.com/read/29091004/performing-gadoxetic-acid-enhanced-mri-after-ct-for-guiding-curative-treatment-of-early-stage-hepatocellular-carcinoma-a-cost-effectiveness-analysis
#19
Chong Hyun Suh, Kyung Won Kim, Seong Ho Park, So Yeon Kim, Dong-Cheol Woo, Sangjin Shin, Junhee Pyo, Atul B Shinagare, Nikhil H Ramaiya, Young-Suk Lim
OBJECTIVE: We determined the cost-effectiveness of two different diagnostic imaging strategies in guiding curative treatment of early-stage hepatocellular carcinoma (HCC). MATERIALS AND METHODS: We developed a decision analytic model using as its starting point a cohort of patients aged 55 years with early-stage HCC detected at dynamic multiphasic CT and with Child-Pugh class A cirrhosis. The model compared two strategies on the initial workup: conventional CT strategy using dynamic multiphasic CT only and gadoxetic acid-enhanced MRI strategy using additional gadoxetic acid-enhanced MRI after initial CT...
November 1, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29076914/small-bowel-metastasis-from-hepatocellular-carcinoma-detected-by-18f-fdg-pet-ct-but-not-by-11c-acetate-pet-ct
#20
Su Woong Yoo, Dong-Yeon Kim, Changho Lee, Jung-Joon Min, Seong Young Kwon
Gastrointestinal tract is rarely a metastatic site of hepatocellular carcinoma (HCC). We present a 43-year-old woman with small bowel metastasis from HCC in which metastasis was detected using F-FDG PET/CT. However, the site of metastasis showed no significant uptake on C-acetate PET/CT. C-acetate PET/CT has a limited value in HCC patients with suspected extrahepatic metastasis, compared with F-FDG PET/CT.
December 2017: Clinical Nuclear Medicine
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