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Hepatocellular carcinoma, imaging

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https://www.readbyqxmd.com/read/28809731/the-histopathological-features-and-ct-mri-imaging-performances-in-hepatic-angiomyolipoma-patients
#1
Huiguo Ding, Hongtao Wei, Hui Liu, Yuhan Chen, Xiaowei Xue, Honglei Weng
AIM: To evaluate the diagnostic value of dynamic contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI) in the differential diagnosis of hepatic angiomyolipoma (HAML) and hepatocellular carcinoma (HCC) and to clarify the relationship between histopathological features and CT or MRI imaging performances in HAML. MATERIAL AND METHODS: Six HAML and 33 non-cirrhotic HCC patients confirmed by histopathology were retrospectively analyzed. The serum biomarkers, CT and MRI examinations were conventionally performed before the confirmatory histological diagnosis...
August 8, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28806321/liver-imaging-reporting-and-data-system-discordance-between-computed-tomography-and-gadoxetate-enhanced-magnetic-resonance-imaging-for-detection-of-hepatocellular-carcinoma-major-features
#2
Victoria Chernyak, Milana Flusberg, Amy Law, Mariya Kobi, Viktoriya Paroder, Alla M Rozenblit
PURPOSE: The goal of this study was to compare agreement between computed tomography (CT) and magnetic resonance imaging (MRI) in the evaluation of the major Liver Imaging Reporting and Data System (LI-RADS) features used in assessment of hepatocellular carcinoma: arterial phase hyperenhancement (APHE), portal venous phase washout (WO), capsule appearance (capsule), and largest diameter (diameter). METHODS: Patients with liver protocol CT and gadoxetate-enhanced MRI within 1 month of each other and at least 1 discrete untreated liver lesion were included...
August 12, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28804578/using-nanoparticles-in-medicine-for-liver-cancer-imaging
#3
REVIEW
Farideh Farokhi Moghadam
One of the most important types of liver cancer is hepatocellular carcinoma (HCC). HCC is the fifth most common cancer, and its correct diagnosis is very important. For the quick diagnosis of HCC, the use of nanoparticles is helpful. The major applications of nanoparticles are in medicine for organ imaging. Two methods of liver imaging are X-ray computed tomography (CT) and magnetic resonance imaging (MRI). In this review, we attempt to summarize some of the contrast agents used in imaging such as superparamagnetic iron oxide nanoparticles (SPIONs) and iron oxide nanoparticles (IONPs), various types of enhanced MRI for the liver, and nanoparticles like gold (AuNPs), which is used to develop novel CT imaging agents...
July 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28799151/contrast-enhanced-ultrasound-features-of-hepatocellular-carcinoma-not-detected-during-the-screening-procedure
#4
Yi Dong, Wen-Ping Wang, Feng Mao, Christoph Dietrich
Aim The aim of this retrospective study is to report on the characteristics of contrast-enhanced ultrasound (CEUS) of primarily not detected hepatocellular carcinoma (HCC) during the screening procedure of patients at risk. Methods Sixty-four patients with a finally solitary and histologically proven HCC not detected HCC during the screening procedure were retrospectively analyzed. Most of HCC lesions (90.6 %, 58/64) measured < 20 mm in diameter. All HCC lesions were not detected during the initial screening procedure but suspected using contrast-enhanced magnetic resonance imaging...
August 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28799103/bleeding-recurrence-and-mortality-following-interventional-management-of-spontaneous-hcc-rupture-results-of-a-multicenter-european-study
#5
Lilian Schwarz, Michael Bubenheim, Johanna Zemour, Astrid Herrero, Fabrice Muscari, Ahmet Ayav, Romain Riboud, Christian Ducerf, J-Marc Regimbeau, Hadrien Tranchart, Emilie Lermite, Gheorghe Petrovai, Amal Suhol, Alexandre Doussot, Lorenzo Capussotti, Jean Jacques Tuech, Yves Patrice Le Treut
BACKGROUND: The incidence of spontaneous rupture of hepatocellular carcinoma (HCC) is low in Europe, at less than 3%. HCC rupture remains a life-threatening complication, with mortality reported between 16 and 30%. The risk of bleeding recurrence has never been clearly evaluated in such clinical situation. The objectives of this study were to evaluate the current risk of mortality related to HCC rupture and to focus on the risk of bleeding recurrence following interventional management...
August 10, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28798937/sparse-contribution-feature-selection-and-classifiers-optimized-by-concave-convex-variation-for-hcc-image-recognition
#6
Wenbo Pang, Huiyan Jiang, Siqi Li
Accurate classification of hepatocellular carcinoma (HCC) image is of great importance in pathology diagnosis and treatment. This paper proposes a concave-convex variation (CCV) method to optimize three classifiers (random forest, support vector machine, and extreme learning machine) for the more accurate HCC image classification results. First, in preprocessing stage, hematoxylin-eosin (H&E) pathological images are enhanced using bilateral filter and each HCC image patch is obtained under the guidance of pathologists...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28798287/non-hypervascular-hypointense-nodules-on-hepatocyte-phase-gadoxetic-acid-enhanced-mr-images-transformation-of-mr-hepatobiliary-hypointense-nodules-into-hypervascular-hepatocellular-carcinomas
#7
Yun Ku Cho, Ju Won Kim, Mi Young Kim, Hyeon Je Cho
Background/Aims: The annual risk of transformation of non-hypervascular magnetic resonance (MR) hepatobiliary phase imaging (HBPI) hypointense nodules into hypervascular hepatocellular carcinomas (HCCs) was evaluated. Methods: Cirrhotic patients with non-hypervascular HBPI hypointense nodules were retrospectively analyzed if they were diagnosed as HCC and MR followed up longer than 1 year during the period from January 2010 to October 2016 with regular intervals of 3 to 6 months...
August 14, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28797231/survival-benefit-of-transarterial-chemoembolization-in-patients-with-metastatic-hepatocellular-carcinoma-a-single-center-experience
#8
Dominik Bettinger, Renan Spode, Nicolas Glaser, Nico Buettner, Tobias Boettler, Christoph Neumann-Haefelin, Thomas Baptist Brunner, Eleni Gkika, Lars Maruschke, Robert Thimme, Michael Schultheiss
BACKGROUND: As prognosis of patients with metastatic hepatocellular carcinoma (HCC) is mainly determined by intrahepatic HCC progression, local treatment with TACE may result in improved OS, although it is not recommended. The purpose of this study was to analyze retrospectively the efficacy of TACE and its impact on OS in patients with metastatic hepatocellular carcinoma (HCC). METHODS: Two hundred and fifteen patients with metastatic HCC who were treated at our Liver Center between 2003 and 2014 were included in this retrospective analysis...
August 10, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28795155/detection-of-urine-dna-markers-for-monitoring-recurrent-hepatocellular-carcinoma
#9
Hie-Won Hann, Surbhi Jain, Grace Park, Jamin D Steffen, Wei Song, Ying-Hsiu Su
AIM: This study aimed to explore the potential of detecting hepatocellular carcinoma (HCC)-associated DNA markers, TP53 249T mutations and aberrant methylation of RASSF1A and GSTP1 genes, for monitoring HCC recurrence. HCC remains a leading cause of death worldwide, with one of the fastest growing incidence rates in the US. While treatment options are available and new ones emerging, there remains a poor prognosis of this disease mostly due to its late diagnosis and high recurrence rate...
2017: Hepatoma Research
https://www.readbyqxmd.com/read/28794043/sorafenib-impedes-rift-valley-fever-virus-egress-by-inhibiting-valosin-containing-protein-function-in-the-cellular-secretory-pathway
#10
Ashwini Brahms, Rajini Mudhasani, Chelsea Pinkham, Krishna Kota, Farooq Nassar, Rouzbeh Zamani, Sina Bavari, Kylene Kehn-Hall
There is an urgent need for therapeutic development to combat Rift Valley fever virus (RVFV) infections, which causes devastating disease in both humans and animals. In an effort to repurpose drugs for RVFV treatment, our previous studies screened a library of FDA-approved drugs. The most promising candidate identified was the hepatocellular and renal cell carcinoma drug, sorafenib. Mechanism of action studies indicated sorafenib targeted a late stage in virus infection and caused a buildup of virions within cells...
August 9, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28791423/preliminary-trial-of-augmented-reality-performed-on-a-laparoscopic-left-hepatectomy
#11
Priyanka Phutane, Emmanuel Buc, Karine Poirot, Erol Ozgur, Denis Pezet, Adrien Bartoli, Bertrand Le Roy
BACKGROUND: Laparoscopic liver surgery is seldom performed, mainly because of the risk of hepatic vein bleeding or incomplete resection of the tumour. This risk may be reduced by means of an augmented reality guidance system (ARGS), which have the potential to aid one in finding the position of intrahepatic tumours and hepatic veins and thus in facilitating the oncological resection and in limiting the risk of operative bleeding. METHODS: We report the case of an 81-year-old man who was diagnosed with a hepatocellular carcinoma after an intraabdominal bleeding...
August 8, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28781818/significance-of-psoas-muscle-thickness-as-an-indicator-of-muscle-atrophy-in-patients-with-hepatocellular-carcinoma-treated-with-sorafenib
#12
Mio Yamashima, Hisamitsu Miyaaki, Takuya Honda, Hidetaka Shibata, Satoshi Miuma, Naota Taura, Kazuhiko Nakao
Sarcopenia has been reported to be associated with the prognosis of patients with liver cirrhosis and hepatocellular carcinoma (HCC). The aim of the present study was to determine whether sarcopenia was associated with the prognosis of patients with HCC treated with sorafenib. A total of 40 patients with HCC who were treated with sorafenib were evaluated. As an indicator of skeletal muscle mass, transverse psoas muscle thickness (TPMT) was measured on computed tomography images at the level of the umbilicus prior to treatment initiation and after 1-3 months of treatment...
September 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28781802/sorafenib-induced-reversible-posterior-leukoencephalopathy-in-patients-with-renal-cell-carcinoma-a-report-of-two-cases
#13
Nobuki Furubayashi, Takahito Negishi, Hidenori Iwai, Kei Nagase, Motonobu Nakamura
Reversible posterior leukoencephalopathy syndrome (RPLS) is a rare clinicoradiological syndrome that is characterized by neurological symptoms, including seizures, headaches, visual abnormalities, confusion and encephalopathy, accompanied by vasogenic edema of the posterior white matter observed on neuroimaging. Sorafenib is an inhibitor of pro-angiogenic receptor tyrosine kinases, such as vascular endothelial growth factor receptor 2, platelet-derived growth factor receptor β, and vascular endothelial growth factor receptor 3...
August 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28780680/mri-for-hepatocellular-carcinoma-a-primer-for-magnetic-resonance-imaging-interpretation
#14
REVIEW
Tina Sanghvi, James Boyum, Ben Spilseth, Robben Schat, Heather Estby, Andrew Taylor
Hepatocellular carcinoma is among the most prevalent solid organ cancers, and, unlike many cancers, may be diagnosed non-invasively by imaging criteria [1] with the preferred modality recently shifting from multiphasic computed tomography (MDCT) to magnetic resonance imaging (MRI). The purpose of this article is to help facilitate radiologists and radiology trainees in the transition to MRI by providing a step-wise approach to exam interpretation to improve the MRI detection of HCC. A methodical, consistent approach to navigating a HCC screening MRI exam, in conjunction with the LI-RADS framework for characterization, should lead to improved HCC detection and diagnosis...
August 5, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28780679/locoregional-therapies-for-hepatocellular-carcinoma-and-the-new-li-rads-treatment-response-algorithm
#15
Ania Kielar, Kathryn J Fowler, Sara Lewis, Vahid Yaghmai, Frank H Miller, Hooman Yarmohammadi, Charles Kim, Victoria Chernyak, Takeshi Yokoo, Jeffrey Meyer, Isabel Newton, Richard K Do
Radiologists play a central role in the assessment of patient response to locoregional therapies for hepatocellular carcinoma (HCC). The identification of viable tumor following treatment guides further management and potentially affects transplantation eligibility. Liver Imaging Reporting and Data Systems (LI-RADS) first introduced the concept of LR-treated in 2014, and a new treatment response algorithm is included in the 2017 update to assist radiologists in image interpretation of HCC after locoregional therapy...
August 5, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28779950/value-of-the-portal-venous-phase-in-evaluation-of-treated-hepatocellular-carcinoma-following-transcatheter-arterial-chemoembolisation
#16
A Lam, D Fernando, C C Sirlin, M Nayyar, S C Goodwin, D K Imagawa, C Lall
AIM: To evaluate the utility of the portal venous phase on multiphasic computed tomography (CT) after treatment of hepatocellular carcinoma (HCC) with trans-arterial chemoembolisation (TACE). MATERIALS AND METHODS: This was a retrospective review of patients who underwent TACE for HCC between 1 April 2012 and 21 December 2014, with appropriate multiphasic, pre- and post-procedural CT examinations. The maximum non-contrast, arterial phase, and portal venous phase attenuation values of the tumour and tumour bed were evaluated within a region of interest (ROI), with values adjusted against background hepatic parenchyma...
August 2, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28777653/combined-hepatocellular-cholang-iocarcinoma-biphenotypic-tumors-potential-role-of-contrast-enhanced-ultrasound-in-diagnosis
#17
Fei Li, Jing Han, Feng Han, Jian-Wei Wang, Rong-Zhen Luo, An-Hua Li, Jian-Hua Zhou
OBJECTIVE: The objective of this study was to evaluate the diagnostic performance of contrast-enhanced ultrasound (CEUS) in differentiating combined hepatocellular cholangiocarcinomas (CHCs) from hepatocellular carcinomas (HCCs) and intrahepatic cholangiocarcinomas (ICCs). MATERIALS AND METHODS: Thirty-three patients with pathologically confirmed CHC and matched control subjects with pathologically confirmed HCC (n = 30) or ICC (n = 32) who underwent preoperative CEUS from January 2005 to December 2015 were enrolled in this study...
August 4, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28771446/micro-hccs-in-rats-with-liver-cirrhosis-paradoxical-effects-with-vascular-disrupting-agent-ca4p
#18
Yewei Liu, Ting Yin, Frederik De Keyzer, Yuanbo Feng, Feng Chen, Jianjun Liu, Shaoli Song, Jie Yu, Vincent Vandecaveye, Johan Swinnen, Guy Bormans, Uwe Himmelreich, Raymond Oyen, Jian Zhang, Gang Huang, Yicheng Ni
We sought to investigate anticancer efficacy of a vascular disrupting agent (VDA) combretastatin A-4 phosphate (CA4P) in relation to tumor size among hepatocellular carcinomas (HCCs) in rats using magnetic resonance imaging (MRI) and postmortem techniques. Nineteen rats with 43 chemically-induced HCCs of 2.8-20.9 mm in size on liver cirrhosis received CA4P intravenously at 10 mg/kg. Tumor-diameter was measured by T2-weighted imaging (T2WI) to define microcancers (< 5 mm) versus larger HCCs. Vascular responses and tissue necrosis were detected by diffusion-weighted imaging (DWI), contrast-enhanced T1-weighted imaging (CE-T1WI) and dynamic contrast enhanced (DCE-) MRI, which were validated by microangiography and histopathology...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28770316/hepatic-arterial-embolization-using-cone-beam-ct-with-tumor-feeding-vessel-detection-software-impact-on-hepatocellular-carcinoma-response
#19
F H Cornelis, A Borgheresi, E N Petre, E Santos, S B Solomon, K Brown
PURPOSE: Dedicated tumor feeding vessel detection software (TFVDS) using cone beam CT has shown a higher sensitivity to detect tumor feeding vessels during hepatic arterial embolization (HAE) of hepatocellular carcinoma (HCC) compared to 2D imaging. Our primary hypothesis was that HCC tumors treated with HAE guided by a TFVDS would show more complete response (CR) than when treated with 2D imaging alone. Secondary analysis of the impact on X-ray exposure was performed. MATERIALS AND METHODS: Nineteen males and 8 females (median age: 69 year, 46-85) with 44 tumors (median size: 38 mm, 6-100) treated with selective HAE between January 2013 and December 2014 were included...
August 2, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28766361/annals-express-diagnostic-specificity-and-sensitivity-of-pivkaii-gp3-cstb-scca1-and-hgf-for-diagnosis-of-hepatocellular-carcinoma-in-patients-with-alcoholic-liver-cirrhosis
#20
Adriana Unic, Lovorka Derek, Marko Duvnjak, Leonardo Patrlj, Mislav Rakic, Milan Kujundzic, Vesna Renjic, Nikola Stokovic, Petra Dinjar, Anita Jukic, Ivica Grgurevic
INTRODUCTION: Despite of some new treatment possibilities the improvement in survival rate for hepatocellular carcinoma (HCC) patients is still poor due to late diagnosis. The aim of this study was to investigate diagnostic sensitivity and specificity of Protein induced by vitamin K absence or antagonist-II (PIVKAII), Glypican-3 (GP3), Cystatin B (CSTB), Squamous cell carcinoma antigen 1 (SCCA1) and Hepatocyte growth factor (HGF) as potential tumour markers for HCC in patients with alcoholic liver cirrhosis (ALC) using imaging techniques (MSCT and MRI) as reference standards...
January 1, 2017: Annals of Clinical Biochemistry
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