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Hepatocellular carcinoma, imaging

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https://www.readbyqxmd.com/read/29340921/hepatic-paragonimiasis-mimicking-hepatocellular-carcinoma
#1
Yi-Xin Lin, Qian-Bin Jia, Yi-Yun Fu, Xian-Ze Xiong
Paragonimiasis is a parasitic lung infection caused by lung flukes of the genus Paragonimus. Ectopic infection may occur but rarely involves the liver. Here, we report a case of hepatic paragonimiasis in a Chinese man who was initially suspected to have hepatocellular carcinoma. He had been previously diagnosed with chronic hepatitis B. No specific symptoms or abnormal blood test results were observed, except for a significant rise in serum alfa-fetoprotein. Magnetic resonance imaging revealed a 12-cm mass with inhomogeneous signal intensity at the left lobe of the liver...
January 16, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29335868/added-value-of-ancillary-imaging-features-for-differentiating-scirrhous-hepatocellular-carcinoma-from-intrahepatic-cholangiocarcinoma-on-gadoxetic-acid-enhanced-mr-imaging
#2
Seo-Youn Choi, Young Kon Kim, Ji Hye Min, Tae Wook Kang, Woo Kyoung Jeong, Soohyun Ahn, Hojeong Won
OBJECTIVES: To determine ancillary features that help distinguish between scirrhous hepatocellular carcinoma (S-HCC) and intrahepatic cholangiocarcinoma (ICC) and investigate added value of ancillary features to enhancement pattern-based diagnosis on gadoxetic acid-enhanced MRI. METHODS: This retrospective study included 96 patients with S-HCCs and 120 patients with ICCs who underwent gadoxetic acid MRI before surgical resection. Two observers reviewed MRIs of the tumours...
January 15, 2018: European Radiology
https://www.readbyqxmd.com/read/29334232/stereotactic-body-radiation-therapy-sbrt-for-hepatocellular-carcinoma-imaging-evaluation-post-treatment
#3
Trenton Kellock, Teresa Liang, Alison Harris, Devin Schellenberg, Roy Ma, Stephen Ho, Wan Wan Yap
Surgical resection, when feasible, is the standard of care for hepatocellular carcinoma (HCC). However, many tumors are not resectable at the time of diagnosis. Recently, stereotactic body radiation therapy (SBRT) has emerged as a non-invasive local therapy for both non-resectable primary hepatic malignancies as well as hepatic metastases. Knowledge of the expected hepatic parenchymal appearance post treatment, as well as potential pitfalls and complications, is essential for accurate evaluation of treatment response...
January 15, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29329568/prospective-longitudinal-quality-of-life-and-survival-outcomes-in-patients-with-advanced-infiltrative-hepatocellular-carcinoma-and-portal-vein-thrombosis-treated-with-yttrium-90-radioembolization
#4
Minzhi Xing, Nima Kokabi, Juan C Camacho, Hyun S Kim
BACKGROUND: To determine the effect of Yttrium-90 (Y90) radioembolization on health-related quality of life (HRQOL) and its effect on overall survival advanced, unresectable infiltrative hepatocellular carcinoma (HCC) patients with concurrent portal vein thrombosis (PVT). METHODS: Consecutive patients with unresectable infiltrative HCC and PVT were recruited. The Short-Form 36 (SF-36) questionnaire was used to assess HRQOL for consecutive patients treated with glass-based Y90 based on a prospective phase II trial...
January 12, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29327116/evaluation-of-hemodynamic-imaging-findings-of-hypervascular-hepatocellular-carcinoma-comparison-between-dynamic-contrast-enhanced-magnetic-resonance-imaging-using-radial-volumetric-imaging-breath-hold-examination-with-k-space-weighted-image-contrast-reconstruction
#5
Masahiro Kurozumi, Yasunari Fujinaga, Yoshihiro Kitou, Akira Yamada, Ayumi Ohya, Yasuo Adachi, Yoshinori Tsukahara, Marcel D Nickel, Katsuya Maruyama, Takeshi Uehara, Shin-Ichi Miyagawa, Masumi Kadoya
PURPOSE: To compare the visualization of hemodynamic imaging findings of hypervascular hepatocellular carcinoma (HCC) on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using radial volumetric imaging breath-hold examination with k-space-weighted image contrast reconstruction (r-VIBE-KWIC) versus dynamic computed tomography during hepatic arteriography (dyn-CTHA). MATERIALS AND METHODS: We retrospectively reviewed the databases of preoperative DCE-MRI using r-VIBE-KWIC, dyn-CTHA, and postoperative pathology of resected specimens...
January 11, 2018: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29324837/health-economic-assessment-of-gd-eob-dtpa-mri-versus-eccm-mri-and-multi-detector-ct-for-diagnosis-of-hepatocellular-carcinoma-in-china
#6
Xiaoning He, Jing Wu, Anke-Peggy Holtorf, Harald Rinde, Shuangshuang Xie, Wen Shen, Jiancun Hou, Xuehua Li, Ziping Li, Jiaming Lai, Yuting Wang, Lin Zhang, Jian Wang, Xuesong Li, Kuansheng Ma, Feng Ye, Han Ouyang, Hong Zhao
Limited data exists in China on the comparative cost of gadolinium ethoxybenzyl diethylenetriamine magnetic resonance imaging (Gd-EOB-DTPA-MRI) with other imaging techniques. This study compared the total cost of Gd-EOB-DTPA-MRI with multidetector computed tomography (MDCT) and extracellular contrast media-enhanced MRI (ECCM-MRI) as initial imaging procedures in patients with suspected hepatocellular carcinoma (HCC). We developed a decision-tree model on the basis of the Chinese clinical guidelines for HCC, which was validated by clinical experts from China...
2018: PloS One
https://www.readbyqxmd.com/read/29319629/patterns-of-discordance-between-pretransplant-imaging-stage-of-hepatocellular-carcinoma-and-posttransplant-pathologic-stage-a-contemporary-appraisal-of-the-milan-criteria
#7
Brett L Ecker, Maarouf A Hoteit, Kimberly A Forde, Christine C Hsu, K Rajender Reddy, Emma E Furth, Evan S Siegelman, Peiman Habibollahi, Edgar Ben-Josef, Paige M Porrett, Peter L Abt, Abraham Shaked, Kim M Olthoff, Matthew H Levine
BACKGROUND: Patients with hepatocellular carcinoma (HCC) exceeding Milan criteria on explant pathology are at increased risk of recurrence and death. Discordance between contemporary magnetic resonance imaging (MRI) and explant pathology, and preoperative characteristics predictive of discordance are not well understood. METHODS: Patients who underwent orthotopic liver transplantation (OLT) for HCC following preoperative MRI were identified in a prospectively collected institutional database (1/2003-12/2013)...
January 10, 2018: Transplantation
https://www.readbyqxmd.com/read/29317591/an-unusual-presentation-of-advanced-intrahepatic-cholangiocarcinoma-when-biopsy-results-fail
#8
Joseph J Tasch, Nirva Dube
BACKGROUND Intrahepatic cholangiocarcinoma is a rare condition which typically occurs in males between 50 and 70 years of age, and presents with symptoms related to biliary obstruction including jaundice, pruritus, and dark urine. Other common symptoms at presentation include abdominal pain, weight loss, and fever. CASE REPORT We present a case of a 67-year-old female initially presenting with chest pain at rest, found to have a lung nodule on diagnostic imaging at the time of admission. On further imaging, a 9 cm liver lesion was incidentally discovered, initially suspicious for hepatocellular carcinoma on imaging, with initial biopsy staining CK7 positive, and CK20 negative...
January 10, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29312973/critical-appraisal-of-chinese-2017-guideline-on-the-management-of-hepatocellular-carcinoma
#9
REVIEW
Di-Yang Xie, Zheng-Gang Ren, Jian Zhou, Jia Fan, Qiang Gao
Hepatocellular carcinoma (HCC) is the fourth most common and the third most lethal cancer in China. An updated version of consensus-based recommendations on the management of HCC has been recently published by a multidisciplinary group of Chinese experts including liver surgeons, hepatic oncologists, radiologists and pathologists. Major changes have been made to the diagnostic criteria. In addition to dynamic multi-detector computed tomography (CT) and magnetic resonance imaging (MRI), gadoxetic acid-enhanced MRI and contrast-enhanced ultrasound (CEUS) are added to the diagnostic imaging tests...
December 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/29312871/patient-specific-three-dimensional-printing-for-pre-surgical-planning-in-hepatocellular-carcinoma-treatment
#10
Elizabeth Perica, Zhonghua Sun
Background: Recently, three-dimensional (3D) printing has shown great interest in medicine, and 3D printed models may be rendered as part of the pre-surgical planning process in order to better understand the complexities of an individual's anatomy. The aim of this study is to investigate the feasibility of utilising 3D printed liver models as clinical tools in pre-operative planning for resectable hepatocellular carcinoma (HCC) lesions. Methods: High-resolution contrast-enhanced computed tomography (CT) images were acquired and utilized to generate a patient-specific 3D printed liver model...
December 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29311419/radiogenomics-of-hepatocellular-carcinoma-multiregion-analysis-based-identification-of-prognostic-imaging-biomarkers-by-integrating-gene-data-a-preliminary-study
#11
Wei Xia, Ying Chen, Rui Zhang, Zhuangzhi Yan, Xiaobo Zhou, Bo Zhang, Xin Gao
To identify prognostic imaging biomarkers for hepatocellular carcinoma (HCC) in contrast-enhanced computed tomography (CECT) with biological interpretations by associating imaging features and gene modules. We retrospectively analyzed 371 patients who had gene expression profiles. For the 38 patients with CECT imaging data, automatic intra-tumor partition was performed resulting in three spatially distinct subregions. We extracted totally 37 quantitative imaging features describing intensity, geometry, and texture from each subregion...
January 9, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29310401/ectopic-hepatocellular-carcinoma-manifesting-multiple-abdominal-masses-a-case-report
#12
RenAn Jin, Qingsong Yu, Xiao Liang
RATIONALE: Ectopic hepatocellular carcinoma (HCC) is a rare disease that mostly originates from an ectopic liver. PATIENT CONCERNS: The patient was admitted with upper abdominal distention for 3 months, which aggravated after meal. DIAGNOSES: A contrast-enhanced computed tomography (CT) scan revealed multiple abdominal masses. After exploratory laparotomy and histological examination, the patient was diagnosed as ectopic HCC. INTERVENTIONS: Exploratory laparotomy was performed for the purpose of diagnosis and treatment...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29299366/bridging-therapy-effectiveness-in-the-treatment-of-hepatocellular-carcinoma-prior-to-orthotopic-liver-transplantation
#13
Maria M Rubinstein, Andreas Kaubisch, Milan Kinkhabwala, John Reinus, Qiang Liu, Jennifer W Chuy
Background: Orthotopic liver transplantation (OLT) is the most effective treatment for hepatocellular carcinoma (HCC) in patients with underlying cirrhosis and portal hypertension. Availability of OLT is limited by donor-organ shortages, which increase patient waiting time until OLT. A variety of bridging therapies (BT) have been used to halt tumor progression in patients on the OLT waiting list. Despite complete radiologic responses following BT, viable tumor is often present in explants...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29287019/preliminary-results-of-high-precision-computed-diffusion-weighted-imaging-for-the-diagnosis-of-hepatocellular-carcinoma-at-3-tesla
#14
Motonori Akagi, Yuko Nakamura, Toru Higaki, Yoshiko Matsubara, Hiroaki Terada, Yukiko Honda, Fuminari Tatsugami, Yasutaka Baba, Makoto Iida, Kazuo Awai
OBJECTIVE: To compare the utility of high-precision computed diffusion-weighted imaging (hc-DWI) and conventional computed DWI (cc-DWI) for the diagnosis of hepatocellular carcinoma (HCC) at 3 T. METHODS: We subjected 75 HCC patients to DWI (b-value 150 and 600 s/mm). To generate hc-DWI we applied non-rigid image registration to avoid the mis-registration of images obtained with different b-values. We defined c-DWI with a b-value of 1500 s/mm using DWI with b-value 150 and 600 s/mm as cc-DWI, and c-DWI with b-value 1500 s/mm using registered DWI with b-value 150 and 600 s/mm as hc-DWI...
December 28, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/29286922/lncrna-heih-in-serum-and-exosomes-as-a-potential-biomarker-in-the-hcv-related-hepatocellular-carcinoma
#15
Chun Zhang, Xi Yang, Quan Qi, Yuhai Gao, Qiang Wei, Shuwen Han
BACKGROUND: Chronic hepatitis C (CHC) is a contagious liver disease that results from infection with the hepatitis C virus (HCV). The most serious consequence of CHC is HCV-related hepatocellular carcinoma (HCC). OBJECTIVE: To illustrate the clinical significance of lncRNA HEIH expression in serum and exosomes in the development of HCV-related HCC. METHODS: Thirty-five CHC, twenty-two HCV-induced cirrhosis and ten HCV-related HCC patients in Huzhou Central Hospital from January 2016 to September 2016 were recruited in the present study...
December 22, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29284589/serum-alpha-fetoprotein-level-per-total-tumor-volume-as-a-predictor-of-recurrence-of-hepatocellular-carcinoma-after-resection
#16
Yeshika Sharma, Michael J Weaver, Daniel R Ludwig, Kathryn Fowler, Neeta Vachharajani, William C Chapman, Jeffrey S Crippin
BACKGROUND: Alpha-fetoprotein has been used as a predictor of recurrence for hepatocellular carcinoma and disease-free survival post-resection. Studies in East Asia have shown that serum alpha-fetoprotein per total tumor volume ratio is a better prognostic indicator than alpha-fetoprotein alone. Similar studies in the United States evaluating serum alpha-fetoprotein to total tumor volume ratio have not been conducted. Its relevance is incompletely understood. METHODS: Consecutive patients undergoing resection for hepatocellular carcinoma at a single tertiary center between 2000 and 2013 were identified for inclusion in this retrospective cohort study...
December 25, 2017: Surgery
https://www.readbyqxmd.com/read/29282384/hepatocyte-nuclear-factor-1%C3%AE-mutated-hepatocellular-adenomas-an-atypical-presentation
#17
Camila Maria Neves Sousa, Patricia Maria Miranda Gadelha, Rafaella de Sousa Cartaxo, George Washington Holanda Pedrosa, Rodrigo Schuler Honorio, José Milton de Castro Lima, Gustavo Rêgo Coelho, Clovis Rêgo Coelho
Hepatocellular adenomas (HCAs) are rare benign monoclonal hepatic tumors that commonly occur in females (3-4 per 100,000 women) due to the use of oral contraceptives, its primary risk factor. Recently, HCAs have been classified into 4 distinct subtypes according to genotypic and phenotypic characteristics and clinical features: inflammatory HCA (40-50%), which are hypervascular with marked peliosis and a tendency to bleed; hepatocyte nuclear factor 1α (HNF1A)-mutated HCA (H-HCA, 30-40%) that are diffusely steatotic and rarely undergo malignant transformation; β-catenin activated HCA (10-15%), which frequently undergo malignant transformation and may seem hepatocellular carcinoma on imaging; and unclassified HCA (10-25%)...
September 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29279500/hepatic-angiomyolipoma-staining-in-the-post-vascular-phase-of-contrast-enhanced-ultrasound-due-to-the-presence-of-macrophages
#18
Kei Endo, Hidekatsu Kuroda, Keisuke Kakisaka, Takayoshi Oikawa, Kei Sawara, Kazuyuki Ishida, Tamotsu Sugai, Yasuhiro Takikawa
A 47-year-old Japanese man was referred to hospital after the detection of a liver tumor. Dynamic computed tomography and Gd-EOB-DTPA-enhanced magnetic resonance imaging were consistent with a diagnosis of hepatocellular carcinoma (HCC). No perfusion defect was observed in the post-vascular phase of contrast-enhanced ultrasound (CEUS). Histopathological staining of the tumor cells was positive for antibodies against HMB-45 and CD68, confirming the diagnosis of hepatic angiomyolipoma (HAML). These findings indicated the presence of macrophages in HAML...
December 27, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29279169/hepatocellular-carcinoma-treated-with-sorafenib-arterial-tumor-perfusion-in-dynamic-contrast-enhanced-ct-as-early-imaging-biomarkers-for-survival
#19
Yuko Nakamura, Tomokazu Kawaoka, Toru Higaki, Wataru Fukumoto, Yukiko Honda, Makoto Iida, Chikako Fujioka, Masao Kiguchi, Hiroshi Aikata, Kazuaki Chayama, Kazuo Awai
OBJECTIVES: To investigate whether hepatic perfusion CT yields early imaging biomarkers predictive of the prognosis of hepatocellular carcinoma (HCC) patients treated with sorafenib. METHODS: We evaluated 36 HCC patients who underwent hepatic perfusion CT before- and one week after sorafenib therapy. We measured arterial and portal perfusion in the hepatic tumor and liver parenchyma [(AP)(PP)tumor], [(AP)(PP)liver]. The perfusion ratio was calculated by dividing the post- by the pre-sorafenib value...
January 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29279148/3d-hybrid-profile-order-technique-in-a-single-breath-hold-3d-t2-weighted-fast-spin-echo-sequence-usefulness-in-diagnosis-of-small-liver-lesions
#20
Kenichiro Hirata, Takeshi Nakaura, Tomoyuki Okuaki, Noriko Tsuda, Narumi Taguchi, Seitaro Oda, Daisuke Utsunomiya, Yasuyuki Yamashita
PURPOSE: We compared the efficacy of three-dimensional (3D) isotropic T2-weighted fast spin-echo imaging using a 3D hybrid profile order technique with a single-breath-hold (3D-Hybrid BH) with a two-dimensional (2D) T2-weighted fast spin-echo conventional respiratory-gated (2D-Conventional RG) technique for visualising small liver lesions. MATERIALS AND METHODS: This study was approved by our institutional review board. The requirement to obtain written informed consent was waived...
January 2018: European Journal of Radiology
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