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Hepatocellular carcinoma, imaging

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https://www.readbyqxmd.com/read/28217239/diagnostic-accuracy-of-gd-eob-dtpa-for-detection-hepatocellular-carcinoma-hcc-a-comparative-study-with-dynamic-contrast-enhanced-magnetic-resonance-imaging-mri-and-dynamic-contrast-enhanced-computed-tomography-ct
#1
Massimo Imbriaco, Serena De Luca, Milena Coppola, Mario Fusari, Michele Klain, Marta Puglia, Pierpaolo Mainenti, Raffaele Liuzzi, Simone Maurea
BACKGROUND: To compare the diagnostic accuracy of hepato-biliary (HB) phase with gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA) with dynamic contrast-enhanced MR imaging (DCEMRI) and contrast-enhanced CT (DCECT) for hepatocellular carcinoma (HCC) detection. MATERIAL/METHODS: 73 patients underwent DCECT and Gd-EOB-DTPA-3T-MR. Lesions were classified using a five-point confidence scale. Reference standard was a combination of pathological evidence and tumor growth at follow-up CT/MR at 12 months...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28213044/hepatocellular-carcinoma-screening-associated-with-early-tumor-detection-and-improved-survival-among-patients-with-cirrhosis-in-the-united-states
#2
Amit G Singal, Sahil Mittal, Olutola A Yerokun, Chul Ahn, Jorge Marrero, Adam Yopp, Neehar D Parikh, Steve J Scaglione
BACKGROUND: Professional societies recommend hepatocellular carcinoma screening in patients with cirrhosis but high-quality data evaluating its effectiveness to improve early tumor detection and survival in "real world" clinical practice are needed. AIMS: Characterize the association between hepatocellular carcinoma screening and early tumor detection, curative treatment, and overall survival among patients with cirrhosis. METHODS: We performed a retrospective cohort study of patients diagnosed with hepatocellular carcinoma between June 2012 and May 2013 at four health systems in the United States...
February 14, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28211805/diagnostic-accuracy-and-interobserver-variability-of-dynamic-vascular-pattern-dvp-in-primary-liver-malignancies-a-simple-semiquantitative-tool-for-the-analysis-of-contrast-enhancement-patterns
#3
B Schellhaas, M J Waldner, R S GÖrtz, F Vitali, Ch Kielisch, L Pfeifer, D Strobel, R Janka, M F Neurath, D Wildner
BACKGROUND: Contrast-enhanced ultrasound (CEUS) is a valuable tool in the diagnostic approach of focal liver lesions, but occasionally subjective and observer-dependent. Semiquantitative evaluation of dynamic CEUS (DCEUS) with standardised software programmes such as Dynamic Vascular Pattern (DVP) could help to improve diagnostic accuracy and objectivity in liver tumour assessment. OBJECTIVES: The present study aimed at evaluation of diagnostic accuracy of DVP in a clinical setting...
February 17, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28210086/prognostic-factors-associated-with-mortality-in-patients-with-gastric-fundal-variceal-bleeding
#4
Keishi Komori, Masaru Kubokawa, Eikichi Ihara, Kazuya Akahoshi, Kazuhiko Nakamura, Kenta Motomura, Akihide Masumoto
AIM: To determine the prognostic factors associated with mortality in patients with gastric fundal variceal (GFV) bleeding. METHODS: In total, 42 patients were endoscopically diagnosed with GFV bleeding from January 2000 to March 2014. We retrospectively reviewed the patients' medical records and assessed their history, etiology of liver cirrhosis, disease conditions, treatment options for GFV bleeding, medications administered before and after onset of GFV bleeding, blood test results (hemoglobin, albumin, and bilirubin concentrations), and imaging results (including computed tomography and abdominal ultrasonography)...
January 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28199760/prediction-of-hepatocellular-carcinoma-recurrence-after-liver-transplantation-comparison-of-4-explant-based-prognostic-models
#5
Charlotte E Costentin, Giuliana Amaddeo, Thomas Decaens, Karim Boudjema, Philippe Bachellier, Fabrice Muscari, Ephrem Salame, Pierre Henri Bernard, Claire Francoz, Sébastien Dharancy, Claire Vanlemmens, Sylvie Radenne, Jérôme Dumortier, Marie Noelle Hilleret, Olivier Chazouilleres, Georges Philippe Pageaux, Julien Calderaro, Alexis Laurent, Françoise Roudot-Thoraval, Christophe Duvoux
AIM: Discordance between pre-LT imaging and explanted liver findings have been reported after liver transplantation (LT) for hepatocellular carcinoma (HCC), suggesting the need of re-assessing the risk of HCC recurrence post LT. Our aims were to compare pre-LT imaging and explants features and to test the performances of four explant-based predictive models of recurrence in an external cohort. METHODS: Staging according to preLT imaging and explant features were compared...
February 15, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28198103/synthesis-of-5%C3%AE-8%C3%AE-ergosterol-peroxide-3-carbamate-derivatives-and-fluorescent-mitochondria-targeting-conjugate-for-enhanced-anticancer-activities
#6
Ming Bu, Tingting Cao, Hongxia Li, Mingzhou Guo, Burton B Yang, Chengchu Zeng, Liming Hu
By inspiration of significant anticancer activity of our previously screened natural ergosterol peroxide (1), a series of novel ergosterol peroxide 3-carbamate derivatives were synthesized and characterized. The anti-proliferative activity of synthesized compounds against human hepatocellular carcinoma cells (HepG2, SK-Hep1) and human breast cancer cells (MCF-7, MDA-MB231) were investigated. Compound 3d, 3f and their hydrochloride exhibited significant in vitro anti-proliferative activity against the tested tumor cell lines, with IC50 values ranging from 0...
February 15, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28197682/intraperitoneal-metastases-after-transarterial-embolization-of-hepatocellular-carcinoma-an-observational-study
#7
Jeffrey M Meier, Spencer C Behr, Eric Jordan, K Pallav Kolli, Benjamin M Yeh
PURPOSE: Transarterial embolization is frequently used to treat local hepatocellular carcinoma (HCC). While various complications are known to occur following transarterial embolization, only one prior case of peritoneal spread of HCC occurring shortly after transarterial chemoembolization has been reported. We present five cases of peritoneal spread of HCC following transarterial embolization (including bland embolization, conventional transarterial chemoembolization (TACE), and doxorubicin-eluting beads TACE) and identify features common among those cases...
February 14, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28193644/tumour-thrombus-of-the-inferior-vena-cava-extending-into-the-right-atrium-in-the-setting-of-colon-cancer
#8
Daniel Meyers, Nancy A Nixon, Angela Franko, Danny Ng, Vincent C Tam
Tumour thrombus is seen in renal cell and hepatocellular carcinoma, but is rarely reported in colorectal cancer. A woman aged 46 years, with metastatic colonic adenocarcinoma, was found to have a large mass in the inferior vena cava (IVC) extending into the right atrium. Although this lesion was initially thought to be bland thrombus, imaging with contrast-enhanced CT scan and contrast-enhanced ultrasound supported the diagnosis of tumour thrombus. Despite the large size of the lesion, the patient was asymptomatic...
February 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28192929/tracing-the-therapeutic-process-of-targeted-aptamer-drug-conjugate-on-cancer-cells-by-surface-enhanced-raman-scattering-spectroscopy
#9
Rong Deng, Huixin Qu, Lijia Liang, Jing Zhang, Biying Zhang, Dianshuai Huang, Shuping Xu, Chongyang Liang, Weiqing Xu
Targeted delivery of chemotherapeutic agents to pathology areas can improve drug efficiency and reduce serious side effects on normal regions. However, their treatment mechanism on cells or cell nuclei is still mysterious due to the lack of in situ characterization methods. In this paper, the specific diagnosis and treatment processes of a targeted antitumor agent (doxorubicin, Dox) functionalized aptamer complex (TLS11a-GC-Dox) toward HepG2 cells, a human hepatocellular carcinoma cell line, were tracked in real time by the surface-enhanced Raman scattering (SERS) spectroscopic technique and dark-field imaging with the assistance of gold nanorod-based nuclear targeted probes, which possess remarkable SERS enhancement ability, specific targeting, and excellent biological compatibility...
February 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28190710/neutrophil-to-lymphocyte-ratio-predicts-disease-progression-following-intra-arterial-therapy-of-hepatocellular-carcinoma
#10
Matthew D Taussig, Mary Ellen Irene Koran, Samdeep K Mouli, Asma Ahmad, Sunil Geevarghese, Jennifer C Baker, Andrew J Lipnik, Fil Banovac, Daniel B Brown
BACKGROUND: Prospectively predicting response to intra-arterial therapy for hepatocellular carcinoma (HCC) is challenging. Neutrophil/lymphocyte ratio (NLR) is a serum biomarker that is associated with survival for multiple malignancies. It was hypothesized that increased NLR would be associated with early disease progression after intra-arterial therapy of HCC. METHODS: The outcomes of 86 treatment-naïve patients who had chemoembolization or radioembolization of HCC between July 2013-July 2014 were reviewed...
February 9, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28190707/safety-and-efficacy-of-percutaneous-microwave-hepatic-ablation-near-the-heart
#11
George A Carberry, Amanda R Smolock, Mircea Cristescu, Shane A Wells, Timothy J Ziemlewicz, Meghan G Lubner, J Louis Hinshaw, Christopher L Brace, Fred T Lee
PURPOSE: To evaluate safety and efficacy of percutaneous hepatic microwave (MW) ablation performed near the heart. MATERIALS AND METHODS: This study reviewed 118 consecutive peripheral (ablation zone margins within 5 mm of liver capsule) percutaneous MW hepatic ablations performed between June 2010 and August 2015. Ablation zones of 27 tumors (22.8%) extended to ≤ 5 mm from myocardium, and these ablations comprised the study group; the remaining ablations formed the control group...
February 9, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28188748/association-between-high-avidity-t-cell-receptors-induced-by-alpha-fetoprotein-derived-peptides-and-anti-tumor-effects-in-patients-with-hepatocellular-carcinoma
#12
Hidetoshi Nakagawa, Eishiro Mizukoshi, Eiji Kobayashi, Toshikatsu Tamai, Hiroshi Hamana, Tatsuhiko Ozawa, Hiroyuki Kishi, Masaaki Kitahara, Tatsuya Yamashita, Kuniaki Arai, Takeshi Terashima, Noriho Iida, Kazumi Fushimi, Atsushi Muraguchi, Shuichi Kaneko
BACKGROUND & AIMS: Levels of alpha fetoprotein (AFP) are measured for surveillance and diagnosis of hepatocellular carcinoma (HCC). We performed a phase 1 trial to evaluate the safety and efficacy of AFP-derived peptides as an anti-tumor vaccine for patients with advanced HCC, and characterized induction of AFP-specific T-cell receptors (TCRs). METHODS: We performed a prospective study, of 15 patients with HCC seen at Kanazawa University Hospital in Japan from March 2010 through March 2012...
February 7, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28187355/multimodality-imaging-of-benign-or-malignant-tumors-in-the-vena-cava-and-its-main-branches
#13
REVIEW
Honglian Wu, Huawei Zhang, Shumin Wang, Xuejun Wu, Dianning Dong, Changhu Liang
Tumors arising from or secondarily involving the vena cava (VC) are broad-spectrum diseases, ranging from benign to malignant. The benign tumors include myxoma, leiomyomatosis and leiomyoma. The primary malignant tumors of the VC are rare, and of these rare entities, leiomyosarcoma is the most frequently encountered. The direct extension of a tumor arising from an adjacent organ such as hepatocellular carcinoma or renal cell carcinoma is more common than primary malignant tumor in the inferior VC. In this article, the authors review the spectrum of VC pathologic processes and the relevant findings from magnetic resonance imaging, ultrasonography, and computed tomography...
October 19, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/28185998/study-on-the-effect-of-chemoembolization-combined-with-microwave-ablation-for-the-treatment-of-hepatocellular-carcinoma-in-rats
#14
Thomas Josef Vogl, Jun Qian, Andreas Tran, Elsie Oppermann, Nagy N Naguib, Huedayi Korkusuz, Nour Eldin A Nour Eldin, Wolf Otto Bechstein
PURPOSE: We aimed to evaluate the combining effects of transarterial chemoembolization (TACE) and open local thermal microwave ablation (MWA) in a hepatocellular carcinoma animal model. METHODS: Tumor cubes were implanted into the liver of 30 male inbred ACI rats. Groups of 10 animals were treated at 13 days (TACE or MWA) and 16 days (MWA) postimplantation with combined therapy (study group A) of TACE (0.1 mg mitomycin C; 0.1 mg iodized oil; 5.0 mg degradable starch microspheres) and MWA (2450 Mhz; 45 s; 35 W), TACE (control group B) or MWA (control group C) alone...
February 10, 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/28184942/radiological-biomarkers-for-assessing-response-to-locoregional-therapies-in-hepatocellular-carcinoma-from-morphological-to-functional-imaging-review
#15
Xiao-Dan Ye, Zuguo Yuan, Jian Zhang, Zheng Yuan
Many hepatocellular carcinoma (HCC) patients do not qualify for curative surgical intervention and are instead treated with locoregional therapies (LRTs) including ablative and endovascular therapies. Assessment of imaging response is essential in the management of HCC for determining efficacy of therapy and as a surrogate marker for improved survival. The established morphological image biomarkers for tumor burden measurement continue to be applied, as size measurement can easily be used in clinical practice...
March 2017: Oncology Reports
https://www.readbyqxmd.com/read/28183144/rapid-deterioration-of-latent-hbv-hepatitis-during-cushing-disease-and-posttraumatic-stress-disorder-after-earthquake
#16
Ryosuke Tashiro, Yoshikazu Ogawa, Teiji Tominaga
Reactivation of the hepatitis B virus (HBV) is a risk in the 350 million HBV carriers worldwide. HBV reactivation may cause hepatocellular carcinoma, cirrhosis, and fulminant hepatitis, and HBV reactivation accompanied with malignant tumor and/or chemotherapy is a critical problem for patients with chronic HBV infection. Multiple risk factors causing an immunosuppressive state can also induce HBV reactivation.We present a case of HBV reactivation during an immunosuppressive state caused by Cushing disease and physical and psychological stress after a disaster...
February 9, 2017: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/28181172/discrepant-imaging-findings-of-portal-vein-thrombosis-with-dynamic-computed-tomography-and-computed-tomography-during-arterial-portography-in-hepatocellular-carcinoma-possible-cause-leading-to-inappropriate-treatment-selection
#17
Hidenori Toyoda, Takashi Kumada, Toshifumi Tada, Kazuyuki Mizuno, Natsuko Kobayashi, Yosuke Inukai, Akira Takeda, Yasuhiro Sone
We encountered a patient with hepatocellular carcinoma who had discrepant imaging findings on portal vein thrombosis with portal phase dynamic computed tomography (CT) and CT during arterial portography (CTAP). CTAP, via the superior mesenteric artery and via the splenic artery, both showed a portal perfusion defect in the right hepatic lobe, indicating portal vein thrombosis in the main trunk of the right portal vein. Portal phase dynamic CT clearly depicted portal perfusion of the same hepatic area. Transarterial chemoembolization was successfully performed, but it was associated with severe liver injury...
February 8, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28180924/ct-based-radiomics-signature-a-potential-biomarker-for-preoperative-prediction-of-early-recurrence-in-hepatocellular-carcinoma
#18
Ying Zhou, Lan He, Yanqi Huang, Shuting Chen, Penqi Wu, Weitao Ye, Zaiyi Liu, Changhong Liang
PURPOSE: To develop a CT-based radiomics signature and assess its ability for preoperatively predicting the early recurrence (≤1 year) of hepatocellular carcinoma (HCC). METHODS: A total of 215 HCC patients who underwent partial hepatectomy were enrolled in this retrospective study, and all the patients were followed up at least within 1 year. Radiomics features were extracted from arterial- and portal venous-phase CT images, and a radiomics signature was built by the least absolute shrinkage and selection operator (LASSO) logistic regression model...
February 8, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28177567/diagnostic-accuracy-of-indocyanine-green-fluorescence-imaging-and-multi-detector-row-computed-tomography-for-identifying-hepatocellular-carcinoma-with-liver-explant-correlation
#19
Koichi Masuda, Junichi Kaneko, Yoshikuni Kawaguchi, Junichi Togashi, Junichi Arita, Nobuhisa Akamatsu, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Sumihito Tamura, Norihiro Kokudo
AIM: Indocyanine green (ICG)-fluorescence imaging is useful for detecting hepatocellular carcinoma (HCC) during surgery, but its accuracy has not been compared to that of multi-detector row computed tomography (MDCT) with liver explant correlation. The aim of present study was to clarify the precise diagnostic accuracy of ICG-fluorescence imaging for detecting HCC in a whole explant liver survey. METHODS: Thirty-three patients with end-stage liver disease (mean age: 53 years) were prospectively enrolled in the present study...
February 8, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28166821/deb-tace-for-intermediate-and-advanced-hcc-initial-experience-in-a-brazilian-cancer-center
#20
Jose Hugo Mendes Luz, Paula M Luz, Henrique S Martin, Hugo R Gouveia, Raphal Braz Levigard, Felipe Diniz Nogueira, Bernardo Caetano Rodrigues, Tiago Nepomuceno de Miranda, Marcelo Henrique Mamede
BACKGROUND: According to Barcelona Clinic Liver Cancer classification transarterial chemoembolization is indicated in patients with Hepatocellular Carcinoma in the intermediate stage. Drug-eluting microspheres can absorb and release the chemotherapeutic agent slowly for 14 days after its intra-arterial administration. This type of transarterial chemoembolization approach appears to provide at least equivalent effectiveness with less toxicity. METHODS: This is a prospective, single-center study, which evaluated 21 patients with intermediate and advanced hepatocellular carcinoma who underwent transarterial chemoembolization with drug-eluting microspheres...
February 6, 2017: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
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