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Hepatocellular carcinoma, MRI

Chansik An, Hyungjin Rhee, Kyunghwa Han, Jin-Young Choi, Young-Nyun Park, Mi-Suk Park, Myeong-Jin Kim, Sumi Park
OBJECTIVES: To examine the added value of considering smooth hypointense rim in the hepatobiliary phase (HBP) of gadoxetic acid-enhanced MRI as capsule appearance for diagnosing tumour capsules and hepatocellular carcinoma (HCC). METHODS: A total of 377 hepatic lesions (330 HCCs, 35 non-HCC malignancies and 12 benign) were included from 345 patients who underwent resection after MRI between January 2008 and December 2011. Two radiologists assessed the presence or absence of conventional capsule appearance and smooth hypointense rim in the HBP, and categorized each hepatic lesion according to the Liver Imaging Reporting and Data System...
October 21, 2016: European Radiology
Nabia S Ikram, Judy Yee, Stefanie Weinstein, Benjamin M Yeh, Carlos U Corvera, Alexander Monto, Thomas A Hope
PURPOSE: To establish if triple-phase arterial imaging improves the detection of arterial phase hyperintense lesions based on arterial phase capture, motion artifact degradation, and lesion enhancement when compared to single-phase imaging. MATERIALS AND METHODS: Patients at risk for hepatocellular carcinoma were imaged at 3.0T. Seventy-three consecutive patients with a standard single-phase MRI and eighty-five consecutive patients were imaged using extracellular contrast with triple arterial phase MRI using three sequential accelerated acquisitions of 8 s...
October 21, 2016: Abdominal Radiology
Hwi Young Jang, Joon-Il Choi, Young Joon Lee, Michael Yong Park, Dong Myung Yeo, Sung Eun Rha, Eun Sun Jung, Young Kyoung You, Dong Goo Kim, Jae Young Byun
PURPOSE: This study aimed to evaluate the accuracy of gadoxetic acid-enhanced magnetic resonance imaging (Gd-EOB-MRI) in predicting eligibility for liver transplantation in patients with hepatocellular carcinoma (HCC) based on Milan criteria (MC). MATERIALS AND METHODS: We reviewed Gd-EOB-MRI of 44 patients who underwent liver transplantation for HCC with cirrhosis for the presence/size of HCCs, vascular invasion, and transplant eligibility based on MC. Hepatocellular carcinoma was diagnosed based on conventional radiological hallmarks (arterial enhancement and washout) or the modified criteria...
October 20, 2016: Journal of Computer Assisted Tomography
Masatoshi Kudo
Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancer deaths worldwide. Sonazoid-enhanced ultrasound and gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced MRI are the most important imaging modalities in diagnosing HCC. There are 2 non-contradictory HCC treatment algorithms in Japan. Hepatic arterial infusion chemotherapy plays an important role in the treatment of advanced HCC with main or branch portal vein invasion. Regorafenib, as a second-line systemic treatment, prolongs survival in patients with intermediate and advanced HCC who progressed on sorafenib...
2016: Digestive Diseases
Takayuki Iwamoto, Yasuharu Imai, Sachiyo Kogita, Takumi Igura, Yoshiyuki Sawai, Kazuto Fukuda, Yoshitaka Yamaguchi, Yasushi Matsumoto, Masanori Nakahara, Osakuni Morimoto, Yasushi Seki, Hiroshi Ohashi, Norihiko Fujita, Masatoshi Kudo, Tetsuo Takehara
OBJECTIVE: We compared the efficacy of contrast-enhanced ultrasound sonography (CEUS) with sonazoid and gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI for the assessment of macroscopic classification of nodular hepatocellular carcinoma (HCC). METHODS: Seventy-seven consecutive patients with 79 surgically resected HCCs who underwent both preoperative CEUS and Gd-EOB-DTPA-enhanced MRI were enrolled in this retrospective study...
2016: Digestive Diseases
Jeong Woo Kim, Chang Hee Lee, Soo Byn Kim, Bit Na Park, Yang Shin Park, Jongmee Lee, Cheol Min Park
PURPOSE: To identify the most reliable imaging features for differentiating hepatocellular carcinoma with paradoxical uptake on the hepatobiliary phase (HCCpara ) from focal nodular hyperplasia (FNH)-like nodules using Gd-EOB-DTPA-enhanced MRI. MATERIALS AND METHODS: This was a retrospective study. Twenty patients with HCCpara and 21 patients with FNH-like nodules were included. The following MRI features were evaluated using 3.0 Tesla unit by two radiologists: signal intensity (SI) on T1-, T2-, and diffusion-weighted imaging (DWI), arterial enhancement pattern, washout appearance on the portal venous phase (PVP) and/or transitional phase (TP), uptake pattern on the hepatobiliary phase (HBP), "T2 scar," "EOB scar," and chemical shift on in- and out-of-phase images...
October 11, 2016: Journal of Magnetic Resonance Imaging: JMRI
Jungang Hu, Majid Maybody, Guang Cao, Xiao Wang, Hui Chen, Xu Zhu, Renjie Yang, Xiaodong Wang
BACKGROUND: To investigate accuracy of intraprocedural cone beam computed tomography (CBCT) compared to fluoroscopy for detection of lipiodol retention pattern during conventional transarterial chemoembolization (cTACE) of hepatocellular carcinoma (HCC) and its correlation with short-term response. METHODS: Between September 2013 and July 2014, 29 patients with HCC underwent chemoembolization of 51 tumors (mean diameter 28.1 mm, range 10.0-136.3 mm). Lipiodol retention pattern was assessed by CBCT at the endpoint of cTACE compared by fluoroscopy...
October 3, 2016: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
S B Paul, E Dhamija, S R Gamanagatti, V Sreenivas, D P Yadav, S Jain, Shalimar, S K Acharya
PURPOSE: To compare the diagnostic accuracy of contrast-enhanced ultrasound (CEUS) with that of multiphase computed tomography (CT) in the evaluation of tumor response to transarterial chemoembolization (TACE) of hepatocellular carcinoma (HCC). MATERIAL AND METHODS: Fifty patients (41 men, 9 women; mean age, 53 years±12.5 [SD]) with a total of 70 HCCs (mean size, 5cm±3 [SD]) were evaluated. Post-TACE therapeutic assessment of HCC was done at 4 weeks. Patients with TACE done earlier and reporting with suspicion for recurrence were also included...
September 27, 2016: Diagnostic and Interventional Imaging
Chia-Hung Wu, Nai-Chi Chiu, Yi-Chen Yeh, Yu Kuo, Sz-Shian Yu, Ching-Yao Weng, Chien-An Liu, Yi-Hong Chou, Yi-You Chiou
BACKGROUND: Beside hepatocellular carcinoma, metastasis, and cholangiocarcinoma, the imaging findings of other relatively uncommon hepatic lesions are less discussed in the literature. Imaging diagnosis of these lesions is a daily challenge. In this article, we review the imaging characteristics of these neoplasms. METHODS: From January 2003 to December 2014, 4746 patients underwent liver biopsy or hepatic surgical resection in our hospital. We reviewed the pathological database retrospectively...
September 2016: Medicine (Baltimore)
Sun Young Yim, Beom Jin Park, Soon Ho Um, Na Yeon Han, Deuk Jae Sung, Sung Bum Cho, Seung Hwa Lee, Min Ju Kim, Jin Yong Jung, Jin Dong Kim, Yeon Seok Seo, Dong Sik Kim, Hyonggin An, Yun Hwan Kim
To compare the diagnostic performance of gadoxetic acid-enhanced magnetic resonance imaging (MRI) with that of computed tomography (CT) during hepatic arteriography and arterial portography (CT HA/AP) for detecting hepatocellular carcinoma (HCC) from small hypervascular nodules.This retrospective study included 38 patients with 131 hypervascular nodules (≤2 cm) who had underwent MRI and CT HA/AP within a 2-week interval. Two observers analyzed MRI while other 2 observers analyzed CT HA/AP. Thereafter, MRI observers reviewed the CT HA/AP and magnetic resonance (MR) images again using both modalities...
September 2016: Medicine (Baltimore)
W M Tai, W P Yong, C Lim, L S Low, C K Tham, T S Koh, Q S Ng, W W Wang, L Z Wang, S Hartano, C H Thng, H Huynh, K T Lim, H C Toh, B C Goh, S P Choo
BACKGROUND: Treatment with sorafenib, although associated with inhibition of tumour growth and angiogenesis in in vivo studies, leads to up-regulation of pERK. The addition of MEK inhibition could potentially abrogate this effect and potentiate anti-tumour activity. This phase I study investigated the maximum tolerated dose (MTD), safety, tolerability, pharmacokinetics (PK) and biomarker correlates of selumetinib combined with sorafenib in patients with advanced hepatocellular carcinoma (HCC)...
September 28, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Roman Kloeckner, Daniel Pinto Dos Santos, Karl-Friedrich Kreitner, Anne Leicher-Düber, Arndt Weinmann, Jens Mittler, Christoph Düber
BACKGROUND: Arterial hyperenhancement and washout on computed tomography and magnetic resonance imaging (MRI) are described by all major guidelines as specific criteria for non-invasive diagnosis of hepatocellular carcinoma (HCC). However, publications on the quantitative assessment of washout in MRI are lacking. Therefore, we evaluated a method for quantitatively measuring and defining washout in MRI in order to determine a cutoff value that allows objective HCC diagnosis. METHODS: We analyzed all patients who underwent liver transplantation for cirrhosis or liver resection for HCC at our institution between 2003 and 2014...
September 29, 2016: BMC Cancer
Gina Kavanaugh, Jason Williams, Andrew Scott Morris, Michael L Nickels, Ronald Walker, Norman Koglin, Andrew W Stephens, M Kay Washington, Sunil K Geevarghese, Qi Liu, Dan Ayers, Yu Shyr, H Charles Manning
PURPOSE: Non-invasive imaging is central to hepatocellular carcinoma (HCC) diagnosis; however, conventional modalities are limited by smaller tumors and other chronic diseases that are often present in patients with HCC, such as cirrhosis. This pilot study evaluated the feasibility of (4S)-4-(3-[(18)F]fluoropropyl)-L-glutamic acid ([(18)F]FSPG) positron emission tomography (PET)/X-ray computed tomography (CT) to image HCC. [(18)F]FSPG PET/CT was compared to standard-of-care (SOC) magnetic resonance imaging (MRI) and CT, and [(11)C]acetate PET/CT, commonly used in this setting...
September 27, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Joonseok Lee, Andrew C Gordon, Hacksung Kim, Wooram Park, Soojeong Cho, Byeongdu Lee, Andrew C Larson, Elena A Rozhkova, Dong-Hyun Kim
Multimodal-imaging probes offer a novel approach, which can provide detail diagnostic information for the planning of image-guided therapies in clinical practice. Here we report targeted multimodal Nd(3+)-doped upconversion nanoparticle (UCNP) imaging reporters, integrating both magnetic resonance imaging (MRI) and real-time upconversion luminescence imaging (UCL) capabilities within a single platform. Nd(3+)-doped UCNPs were synthesized as a core-shell structure showing a bright visible emission upon excitation at the near infrared (minimizing biological overheating and increasing tissue penetration depth) as well as providing strong MRI T2 contrast (high r2/r1 ratio)...
December 2016: Biomaterials
Aiman Obed, Abdalla Bashir, Anwar Jarrad
BACKGROUND Hepatitis C virus (HCV) genotype 4 (GT-4) is widespread in the Middle East, where it is responsible for the majority of HCV infections. It shows moderate treatment response rates when compared to other genotypes in the current era of interferon-based regimens. However, in the era of direct acting antiviral (DAA) drugs, its response is at least as good as observed for HCV genotypes 1-3. CASE REPORT We present a case of a 44-year-old patient with HCV cirrhosis. Since 2007, he has been treated for HCV infection with multiple ineffective regimens of interferon (INF) and ribavirin...
September 20, 2016: American Journal of Case Reports
Xiaoxiao Qin, Xiaojun Hu, Chun Wu, Mingyue Cai, Zhengran Li, Lina Zhang, Liteng Lin, Wensou Huang, Kangshun Zhu
RATIONALE AND OBJECTIVES: The study aimed to evaluate the feasibility of imaging or tracking hepatocellular carcinoma cells by modifying these cells to carry a multimodality reporter gene, enabling fluorescence, bioluminescence, and magnetic resonance imaging (MRI) in vitro and in vivo. MATERIALS AND METHODS: HepG2 cells were labeled with the enhanced green fluorescent protein (EGFP)/luciferase2/ferritin-the multimodality reporter gene (labeled HepG2 cells). The labeled and unlabeled HepG2 cells were cultured in vitro and then injected subcutaneously into mice as a hepatoma model in vivo...
September 15, 2016: Academic Radiology
Chase Constant, Silke Hecht, Linden E Craig, Cassie N Lux, Claire M Cannon, Gordon A Conklin
Hepatocellular carcinoma is the most common primary hepatic tumor in dogs and is amenable to surgical resection in many cases. Unfortunately, overlap of sonographic findings between benign and malignant hepatic lesions typically requires more invasive diagnostic tests to be performed (e.g., biopsy for histopathology). The availability of a noninvasive diagnostic test to identify hepatocellular carcinoma would be beneficial. The use of a liver-specific magnetic resonance imaging (MRI) contrast agent such as gadoxetate disodium (Gd-EOB-DTPA; Eovist® or Primovist®) has improved lesion detection in human patients...
September 15, 2016: Veterinary Radiology & Ultrasound
Wu Zhou, Lijuan Zhang, Kaixin Wang, Shuting Chen, Guangyi Wang, Zaiyi Liu, Changhong Liang
PURPOSE: To investigate the performance of texture analysis in characterizing malignancy of hepatocellular carcinomas (HCCs) based on contrast-enhanced magnetic resonance imaging (MRI). MATERIALS AND METHODS: Gd-DTPA contrast-enhanced MRI data of 46 consecutive subjects with resected HCC were retrieved. The mean intensity and gray-level run-length nonuniformity (GLN) were quantified as the discriminative features based on the arterial phase images and compared between groups with different histological grading using independent Student's t-test or Welch-Satterthwaite approximate t-test for data following a normal distribution and Mann-Whitney U-test for data violating the normal distribution...
September 14, 2016: Journal of Magnetic Resonance Imaging: JMRI
Sangeeta Taneja, Rajesh Taneja, Vikas Kashyap, Abhishek Jha, Amarnath Jena
Ga-PSMA based integrated PET/MRI is emerging as a novel imaging technique for the staging of prostate carcinoma. We report a case of a 77-year-old man with raised prostate-specific antigen who presented to us for Glu-NH-CO-NH-Lys-(Ahx)-[Ga-(HBED-CC)] (Ga-PSMA) simultaneous PET/MRI scan for prostate cancer evaluation. A PSMA avid hepatic lesion on the background of cirrhotic liver was noted apart from PSMA avid lesion in the peripheral gland of the prostate. On histopathological examination, the hepatic lesion turned out to be hepatocellular carcinoma...
September 7, 2016: Clinical Nuclear Medicine
Sung Il Park, Il Jung Kim, Shin Jae Lee, Min Woo Shin, Won Sun Shin, Yong Eun Chung, Gyoung Min Kim, Man Deuk Kim, Jong Yun Won, Do Yun Lee, Jin Sub Choi, Kwang-Hyub Han
OBJECTIVE: To evaluate the feasibility of angled cool-tip electrode for radiofrequency ablation of small superficial subcapsular liver tumors abutting abdominal wall, in order to traverse normal liver parenchyma, and thereby, obtain favorable configuration of ablation margin. MATERIALS AND METHODS: In this study, we retrospectively analyzed 15 small superficial subcapsular liver tumors abutting abdominal wall in 15 patients, treated with radiofrequency ablation from March 2013 to June 2015 using a cool-tip electrode manually modified to create 25-35° angle at the junction between exposed and insulated segments...
September 2016: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
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