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B Schellhaas, D Wildner, L Pfeifer, R S Goertz, A Hagel, M F Neurath, D Strobel
Purpose: To develop a contrast-enhanced ultrasound algorithm (LI-RADS-CEUS = liver imaging reporting and data system with contrast-enhanced ultrasound) for the diagnosis of hepatocellular carcinoma (HCC) in patients at risk. Materials and Methods: A CEUS algorithm (LI-RADS-CEUS) was designed analogously to CT- and MRI-based LI-RADS. LI-RADS-CEUS was evaluated retrospectively in 50 patients at risk with confirmed HCC or non-HCC lesions (test group) with subsequent validation in a prospective cohort of 50 patients (validation group)...
August 3, 2016: Ultraschall in der Medizin
Ijin Joo, Jeong Min Lee, Dong Ho Lee, Su Joa Ahn, Eun Sun Lee, Joon Koo Han
PURPOSE: To investigate the Liver Imaging Reporting and Data System (LI-RADS) v2014 categorization of hepatocellular carcinomas (HCCs) on gadoxetic acid-enhanced magnetic resonance imaging (Gd-EOB-MRI) in comparison with multiphasic multidetector computed tomography (MDCT). MATERIALS AND METHODS: Our Institutional Review Board approved this retrospective study and waived the requirement for informed consent. We included 182 high-risk patients with 216 pathologically confirmed HCCs who underwent both Gd-EOB-MRI at 1...
July 30, 2016: Journal of Magnetic Resonance Imaging: JMRI
Giovan Giuseppe Di Costanzo, Giuseppina Marino Marsilia, Raffaella Tortora, Giuseppe Di Costanzo, Alfonso Ragozzino
No abstract text is available yet for this article.
July 2016: American Journal of Gastroenterology
Chansik An, Gulbahor Rakhmonova, Jin-Young Choi, Myeong-Jin Kim
Liver Imaging Reporting and Data System (LI-RADS) is a system for interpreting and reporting of computed tomography and magnetic resonance imaging of the liver in patients at risk for hepatocellular carcinoma (HCC). LI-RADS has been developed to address the limitations of prior imaging-based criteria including the lack of established consensus regarding the exact definitions of imaging features, binary categorization (either definite or not definite HCC), and failure to consider non-HCC malignancies. One of the most important goals of LI-RADS is to facilitate clear communication between all the personnel involved in the diagnosis and treatment of HCC, such as radiologists, hepatologists, surgeons, and pathologists...
June 2016: Clinical and Molecular Hepatology
Wei Zhao, Wenzheng Li, Xiaoping Yi, Yigang Pei, Hui Liu, Liqing Zhang, Huaping Liu
OBJECTIVE: To evaluate the diagnostic value of liver imaging reporting and classification criteria of data system (LI-RADS) MRI on primary hepatic carcinoma (HCC).
 METHODS: The MRI images of 100 patients (72 patients with HCC, 4 with regenerative nodules, 13 with hemangioma, 4 with liver cyst, 3 with Liver abscess, 2 with inflammatory pseudotumor, 1 with hepatic arteriovenous fistula, 1 with Limitations of steatosis) with liver disease were collected in Xiangya Hospital from January, 2014 to January, 2015...
April 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Eric C Ehman, Spencer C Behr, Sarah E Umetsu, Nicholas Fidelman, Ben M Yeh, Linda D Ferrell, Thomas A Hope
PURPOSE: To compare frequency and inter-reader agreement for LI-RADS v2014 major features at CT vs. MRI in pathology-proven cases of hepatocellular carcinoma. METHODS: Pathology reports and imaging studies from patients having undergone liver transplant or hepatectomy for hepatocellular carcinoma were reviewed. Size, location, washout, and capsule appearance for each lesion were recorded by two radiologists. Cohen's kappa and intraclass correlation coefficients (ICC) were calculated...
May 2016: Abdominal Radiology
Borna K Barth, Olivio F Donati, Michael A Fischer, Erika J Ulbrich, Christoph A Karlo, Anton Becker, Burkhard Seifert, Caecilia S Reiner
RATIONALE AND OBJECTIVES: This study aimed to analyze interreader agreement and diagnostic accuracy of Liver Imaging Reporting and Data System (LI-RADS) in comparison to a nonstandardized 5-point scale and to assess reader acceptance of LI-RADS for clinical routine. MATERIALS AND METHODS: Eighty-four consecutive patients at risk for hepatocellular carcinoma who underwent liver magnetic resonance imaging were included in this Health Insurance Portability and Accountability Act-compliant retrospective study...
September 2016: Academic Radiology
Lauren M B Burke, Keitaro Sofue, Madavi Alagiyawanna, Viragi Nilmini, Andrew J Muir, Kingshuk R Choudhury, Richard C Semelka, Mustafa R Bashir
PURPOSE: The purpose of this study was to characterize the MR imaging features and outcomes of liver imaging reporting and data system (LI-RADS) category 4 (LR4) nodules, with an emphasis on upgrade to category 5 (LR5) and development of contraindications to curative therapy. METHODS: Institutional review board approval was obtained for this retrospective, dual-institutional Health Insurance Portability and Accountability Act-compliant study. The requirement for informed consent was waived...
September 2016: Abdominal Radiology
Masahiro Tanabe, Akihiko Kanki, Tanya Wolfson, Eduardo A C Costa, Adrija Mamidipalli, Marilia P F D Ferreira, Cynthia Santillan, Michael S Middleton, Anthony C Gamst, Yuko Kono, Alexander Kuo, Claude B Sirlin
Purpose To determine the proportion of untreated Liver Imaging Reporting and Data System (LI-RADS) version 2014 category 2, 3, and 4 observations that progress, remain stable, or decrease in category and to compare the cumulative incidence of progression in category. Materials and Methods In this retrospective, longitudinal, single-center, HIPAA-compliant, institutional review board-approved study, 157 patients (86 men and 71 women; mean age ± standard deviation, 59.0 years ± 9.7) underwent two or more multiphasic computed tomographic (CT) or magnetic resonance (MR) imaging examinations for hepatocellular carcinoma surveillance, with the first examination in 2011 or 2012...
October 2016: Radiology
Robert M Hicks, Judy Yee, Michael A Ohliger, Stefanie Weinstein, Jeffrey Kao, Nabia S Ikram, Thomas A Hope
PURPOSE: To evaluate the performance of diffusion-weighted imaging (DWI) and T2-weighted single shot fast spin-echo (SSFSE) imaging of the liver in the detection of hepatocellular carcinoma (HCC) in reference to the LI-RADS classification system. METHODS: MR images of 40 patients with 68 LI-RADS grade 3-5 lesions were analyzed. Two readers independently reviewed sequences and characterized lesion signal intensity, followed by consensus evaluation. CE-MRI served as reference standard...
September 2016: Magnetic Resonance Imaging
Ijin Joo, Jeong Min Lee, Sang Min Lee, Jeong Sub Lee, Jin Young Park, Joon Koo Han
PURPOSE: To investigate the utility of Liver Imaging Reporting and Data System (LI-RADS) v2014 for intrahepatic mass-forming cholangiocarcinomas (IMCC) on gadoxetic acid-enhanced magnetic resonance imaging (MRI). MATERIALS AND METHODS: This retrospective study was approved by our Institutional Review Board with waiver of informed consent. Pathologically confirmed IMCCs (n = 35) and hepatocellular carcinomas (HCCs) (n = 71) in patients with chronic hepatitis B or cirrhosis who had undergone gadoxetic acid-enhanced 3...
April 18, 2016: Journal of Magnetic Resonance Imaging: JMRI
Sang Hyun Choi, Jae Ho Byun, So Yeon Kim, So Jung Lee, Hyung Jin Won, Yong Moon Shin, Pyo Nyun Kim
OBJECTIVES: The aim of this study was to validate the Liver Imaging Reporting and Data System (LI-RADS) v2014 category 4 (LR-4) and 5 (LR-5) criteria on gadoxetate disodium-enhanced magnetic resonance imaging (MRI) in patients with chronic liver disease. MATERIALS AND METHODS: Between January and December 2012, 300 patients with chronic liver disease who had hepatic nodules 3.0 cm or smaller at surveillance ultrasonography and gadoxetate disodium-enhanced MRI were included...
August 2016: Investigative Radiology
Theodora A Potretzke, Benjamin R Tan, Maria B Doyle, Elizabeth M Brunt, Jay P Heiken, Kathryn J Fowler
OBJECTIVE: The purpose of this study was to determine the frequency with which biphenotypic primary liver carcinoma (also called hepatocholangiocarcinoma) may be misclassified as hepatocellular carcinoma (HCC) when only Liver Imaging Reporting and Data System (LI-RADS) major features are used and after consideration of ancillary features. MATERIALS AND METHODS: A review of all pathologically proven biphenotypic primary liver carcinomas diagnosed at one institution from 2006 to 2014 was performed...
July 2016: AJR. American Journal of Roentgenology
Michael T Corwin, Ghaneh Fananapazir, Michael Jin, Ramit Lamba, Mustafa R Bashir
OBJECTIVE: The purpose of this study is to determine whether focal liver observations are categorized differently by CT and MRI using the Liver Imaging and Reporting Data System (LI-RADS). MATERIALS AND METHODS: We performed a retrospective review of 58 patients at risk for hepatocellular carcinoma who underwent liver protocol CT and MRI within 1 month of each other. Two readers assigned a LI-RADS category for all focal liver observations in consensus. A significant category upgrade was defined as a change from LI-RADS categories 1 and 2 or nonvisualization to LI-RADS categories 3-5, from LI-RADS category 3 to category 4 or 5, from LI-RADS category 4 to category 5, or from any category to LI-RADS category 5V...
February 2016: AJR. American Journal of Roentgenology
Yu-Dong Zhang, Fei-Peng Zhu, Xun Xu, Qing Wang, Chen-Jiang Wu, Xi-Sheng Liu, Hai-Bin Shi
RATIONALE AND OBJECTIVES: The Liver Imaging Reporting and Data System (LI-RADS) is a newly developed nomogram for standardizing the performance and interpretation of liver imaging. However, it is unclear which imaging technique is optimal to exactly define LI-RADS scale. This study aims to determine the concordance of computed tomography (CT) and magnetic resonance imaging (MRI) for the classification of hepatic nodules (HNs) using a LI-RADS scoring system. MATERIALS AND METHODS: Major imaging features (arterial hyper-enhancement, washout, pseudo-capsule, diameter, and tumor embolus) on CT versus MRI for 118 HNs in 84 patients with diffuse liver disease were rated independently using LI-RADS by two groups of readers...
March 2016: Academic Radiology
Keitaro Sofue, Claude B Sirlin, Brian C Allen, Rendon C Nelson, Carl L Berg, Mustafa R Bashir
PURPOSE: To determine whether reader perception of a capsule affects reader interpretation of washout in hypervascular liver nodules at dynamic magnetic resonance imaging (MRI) in patients at risk for hepatocellular carcinoma (HCC). MATERIALS AND METHODS: This retrospective study was Institutional Review Board (IRB)-approved and Health Insurance Portability and Accountability Act (HIPAA)-compliant, with waiver of informed consent. MRI reports for 111 hypervascular liver nodules (median 2...
June 2016: Journal of Magnetic Resonance Imaging: JMRI
Li Tang, Hui-Xiong Xu, Xiao-Wan Bo, Bo-Ji Liu, Xiao-Long Li, Rong Wu, Dan-Dan Li, Lin Fang, Xiao-Hong Xu
OBJECTIVE: The purpose of this study was to evaluate the diagnostic performance of a novel quantitative shear wave elastography (SWE) of virtual touch tissue imaging quantification (VTIQ) in diagnosis of breast lesions. METHODS: The conventional ultrasound (US) and VTIQ images of 133 pathologically proven breast lesions in 98 patients were assessed. The breast lesions were classified by US breast imaging reporting and data system (BI-RADS) category. The maximum, minimum, mean and median shear wave velocity (SWV) values on VTIQ in the lesions were obtained...
2015: International Journal of Clinical and Experimental Medicine
Quan Zhou, Weigang Zhang, Lei Chen, Tieyi Yan, Liyu Zhang, Li Wang, Biao Wang
A novel optical fiber torsion sensor head is proposed. A section of polarization-maintaining fiber (PMF) is spliced between single mode fiber (SMF), and a twist taper is fabricated by a commercial electric-arc fusion splicer in the middle of the PMF. The asymmetric characteristics are obtained by the twist taper so that a fiber torsion sensor with directional discrimination is fabricated. Due to the characteristics of the asymmetric structure, the torsion sensitivity for the twist rate from 0 rad/m to -8 rad/m reaches 2...
September 7, 2015: Optics Express
Li Xie, Min Yan, Xiaonan Wang, Jing Ye, Kai Mi, Shanshan Yan, Xianglian Niu, Hongjun Li, Maosheng Sun
NSP4 and VP7 are important functional proteins of rotavirus. Proper combination of viral gene expression is favorable to improving the protection effect of subunit vaccine. In the present study, We evaluated the immunogenicity and efficacy of the bicistronic recombinant adenovirus (rAd-NSP4-VP7) and two single-gene expressing adenoviruses (rAd-NSP4, rAd-VP7). The three adenovirus vaccines were used to immunize mice by intramuscular or intranasal administration. The data showed significant increases in serum antibodies, T lymphocyte subpopulations proliferation, and cytokine secretions of splenocyte in all immunized groups...
December 2, 2015: Virus Research
Shao-Yun Hao, Bing Ou, Lu-Jing Li, Yu-Lan Peng, Yi Wang, Li-Sha Liu, Ying Xiao, Shou-Jun Liu, Chang-Jun Wu, Yu-Xin Jiang, Shyam Sundar Parajuly, Ping Xu, Yi Hao, Jing Li, Hui Zhi, Bao-Ming Luo
OBJECTIVES: The purpose was to evaluate whether BI-RADS (the Breast Imaging Recording and Data System) combined with UE (ultrasound elastography) could improve the differentiation and characterization of benign and malignant breast lesions by comparing with BI-RADS. METHODS: A total of 1080 patients with 1194 breast lesions were studied retrospectively at 8 different institutions from 3 geographic areas across China (North, South, and West) from June 2010 to March 2012...
December 2015: European Journal of Radiology
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