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JOURNAL ARTICLE
Neha Atulkumar Singh, Austin W Goodrich, Jonathan Graff-Radford, Mary M Machulda, Irene Sintini, Arenn F Carlos, Carling G Robinson, Robert I Reid, Val J Lowe, Clifford R Jack, Ronald C Petersen, Bradley F Boeve, Keith A Josephs, Kejal Kantarci, Jennifer L Whitwell
Posterior cortical atrophy (PCA) and dementia with Lewy bodies (DLB) show distinct atrophy and overlapping hypometabolism profiles, but it is unknown how disruptions in structural and functional connectivity compare between these disorders and whether breakdowns in connectivity relate to either atrophy or hypometabolism. Thirty amyloid-positive PCA patients, 24 amyloid-negative DLB patients and 30 amyloid-negative cognitively unimpaired (CU) healthy individuals were recruited at Mayo Clinic, Rochester, MN, and underwent a 3T head MRI, including structural MRI, resting state functional MRI (rsfMRI) and diffusion tensor imaging (DTI) sequences, as well as [18 F] fluorodeoxyglucose (FDG) PET...
March 3, 2024: NeuroImage
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JOURNAL ARTICLE
Esra Porgalı Zayman, Mehmet Fatih Erbay
Recent developments in neuroimaging have improved our understanding of the biological mechanisms underlying schizophrenia. However, neuroimaging findings in treatment-resistant schizophrenia (TRS) remain unclear. In the present study, we aimed to explore potential neuroanatomical regions that may be associated with treatment resistance in schizophrenia patients by comparing neuroanatomical regions of TRS and non-TRS patients using the MRICloud method. A total of 33 schizophrenia patients (meeting DSM 5 diagnostic criteria for schizophrenia) were included in the study...
April 2024: Psychiatry Research. Neuroimaging
#3
Xinyu Ji, Ke Xuan Li, Leonardo Furtado Freitas, Philippe Huot
Metronidazole is a commonly used antibiotic with anaerobic bacterial, protozoal, and microaerophilic bacterial coverage. Encephalopathy and peripheral neurotoxicity are rare but known adverse events with prolonged metronidazole use, which can be difficult to distinguish from other causes of delirium in acutely ill patients. Definitive diagnosis can be made by brain magnetic resonance imaging (MRI), which often reveals symmetric bilateral hypersignal demyelination lesions typically involving the dentate nuclei, splenium of the corpus collosum, midbrain, dorsal medulla, and pons...
January 2024: Radiology Case Reports
#4
Ganaraja Valakunja Harikrishna, Mundlamuri Ravindranadh Chowdary, Seena Vengalil, Atchayaram Nalini, Ravi Yadav
Dystonia has been described in a few cases with SSPE, but there are only very few reports with status dystonicus and none from South India. Here, we report a six-year-old child presenting with severe dystonic posturing of all four limbs and trunk for 10 days duration following a febrile illness and initially treated elsewhere as viral encephalitis. Scalp EEG showed periodic high-amplitude slow wave discharges. MRI brain showed T2/FLAIR hyperintensity in bilateral frontal, left parietal, and deep white matter, extending across the corpus collosum with diffuse cerebral atrophy...
2023: Neurology India
#5
JOURNAL ARTICLE
Sanja Kilian, Stefan Du Plessis, Jean-Paul Fouche, Hilmar Luckhoff, Freda Scheffler, Lebogang Phahladira, Chanelle Buckle, Retha Smit, Riaan Olivier, Leslie Swartz, Robin Emsley, Laila Asmal
OBJECTIVE: Both cognitive impairment and alterations in white matter tissue microstructure are well recognised in schizophrenia. We investigated whether differences in white matter microstructure underpin cognitive impairments in patients with first-episode schizophrenia spectrum disorders when controlling for multiple confounding factors. METHODS: We employed a cross-sectional study design and compared fractional anisotropy (FA) between individuals diagnosed with first- episode schizophrenia spectrum disorders (FES) (n = 68) and matched healthy controls (n = 120)...
November 24, 2022: Schizophrenia Research
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JOURNAL ARTICLE
Deanna M Barch, Xiao Hua, Sridhar Kandala, Michael P Harms, Ashley Sanders, Rebecca Brady, Rebecca Tillman, Joan L Luby
INTRODUCTION: Compared to research on adults with depression, relatively little work has examined white matter microstructure differences in depression arising earlier in life. Here we tested hypotheses about disruptions to white matter structure in adolescents with current and past depression, with an a priori focus on the cingulum bundles, uncinate fasciculi, corpus collosum, and superior longitudinal fasciculus. METHODS: One hundred thirty-one children from the Preschool Depression Study were assessed using a Human Connectome Project style diffusion imaging sequence which was processed with HCP pipelines and TRACULA to generate estimates of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD)...
November 2, 2022: Depression and Anxiety
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Road to a rare diagnosis: Description of novel unbalanced translocation causing partial trisomy 17p.
Melab Musabi, Ayman Saker, Jessi Baer, Peter Wang, Anahita Mohseni Meybodi, Chitra Prasad, Soume Bhattacharya
Trisomy 17 is a rare chromosomal disorder. Existing literature on the topic is limited and mostly refer to mosaic Trisomy 17 cases. Our report summarizes the 70-day clinical course of a late preterm neonate with partial Trisomy 17p karyotype 46,XY,der(14)t(14;17)(p11.1;p11.2) dpat. Trisomy 17 due to unbalanced translocation is rare, and our case elaborates the clinical presentation with intestinal malfunction without any anatomical pathology and urethral diverticulum and the ethical dilemma in decision-making...
October 2022: Clinical Case Reports
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JOURNAL ARTICLE
Fatima Sfifou, Mounir Ouzir, El Mehdi Hakkou, Majdouline Obtel, Hassan Errihani, Abderrahmane Al Bouzidi, Redouane Abouqal, Abdessamad El Ouahabi, Nadia Cherradi
The Moroccan Glioma Dataset contains the clinical data of 32 patients with glioma. The clinical data including demographic data (age, sex), tumor characteristics (tumor location, Glioma type, Karnofsky performance score, mitotic activity, cell density, necrosis, endotheliocapillary vascular proliferation, MRI contrast pick-up, corpus collosum infiltration and Oedema), treatment strategy (subtotal resection, gross resection, biopsy, radiotherapy, chemotherapy), expression pattern of tumor biomarkers (IDH1, HIF-1alpha, P53, Ki-67), and survival data (Kaplan-Meier curves for disease progression)...
June 2022: Data in Brief
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JOURNAL ARTICLE
Sarah E M Stephenson, Gregory Costain, Laura E R Blok, Michael A Silk, Thanh Binh Nguyen, Xiaomin Dong, Dana E Alhuzaimi, James J Dowling, Susan Walker, Kimberly Amburgey, Robin Z Hayeems, Lance H Rodan, Marc A Schwartz, Jonathan Picker, Sally A Lynch, Aditi Gupta, Kristen J Rasmussen, Lisa A Schimmenti, Eric W Klee, Zhiyv Niu, Katherine E Agre, Ilana Chilton, Wendy K Chung, Anya Revah-Politi, P Y Billie Au, Christopher Griffith, Melissa Racobaldo, Annick Raas-Rothschild, Bruria Ben Zeev, Ortal Barel, Sebastien Moutton, Fanny Morice-Picard, Virginie Carmignac, Jenny Cornaton, Nathalie Marle, Orrin Devinsky, Chandler Stimach, Stephanie Burns Wechsler, Bryan E Hainline, Katie Sapp, Marjolaine Willems, Ange-Line Bruel, Kerith-Rae Dias, Carey-Anne Evans, Tony Roscioli, Rani Sachdev, Suzanna E L Temple, Ying Zhu, Joshua J Baker, Ingrid E Scheffer, Fiona J Gardiner, Amy L Schneider, Alison M Muir, Heather C Mefford, Amy Crunk, Elizabeth M Heise, Francisca Millan, Kristin G Monaghan, Richard Person, Lindsay Rhodes, Sarah Richards, Ingrid M Wentzensen, Benjamin Cogné, Bertrand Isidor, Mathilde Nizon, Marie Vincent, Thomas Besnard, Amelie Piton, Carlo Marcelis, Kohji Kato, Norihisa Koyama, Tomoo Ogi, Elaine Suk-Ying Goh, Christopher Richmond, David J Amor, Jessica O Boyce, Angela T Morgan, Michael S Hildebrand, Antony Kaspi, Melanie Bahlo, Rún Friðriksdóttir, Hildigunnur Katrínardóttir, Patrick Sulem, Kári Stefánsson, Hans Tómas Björnsson, Simone Mandelstam, Manuela Morleo, Milena Mariani, Marcello Scala, Andrea Accogli, Annalaura Torella, Valeria Capra, Mathew Wallis, Sandra Jansen, Quinten Weisfisz, Hugoline de Haan, Simon Sadedin, Sze Chern Lim, Susan M White, David B Ascher, Annette Schenck, Paul J Lockhart, John Christodoulou, Tiong Yang Tan
Neurodevelopmental disorders are highly heterogenous conditions resulting from abnormalities of brain architecture and/or function. FBXW7 (F-box and WD-repeat-domain-containing 7), a recognized developmental regulator and tumor suppressor, has been shown to regulate cell-cycle progression and cell growth and survival by targeting substrates including CYCLIN E1/2 and NOTCH for degradation via the ubiquitin proteasome system. We used a genotype-first approach and global data-sharing platforms to identify 35 individuals harboring de novo and inherited FBXW7 germline monoallelic chromosomal deletions and nonsense, frameshift, splice-site, and missense variants associated with a neurodevelopmental syndrome...
April 7, 2022: American Journal of Human Genetics
#10
JOURNAL ARTICLE
Natalia Egorova-Brumley, Mohamed Salah Khlif, Emilio Werden, Laura J Bird, Amy Brodtmann
Dynamic whole-brain changes occur following stroke, and not just in association with recovery. We tested the hypothesis that the presence of a specific behavioural deficit after stroke would be associated with structural decline (atrophy) in the brain regions supporting the affected function, by examining language deficits post-stroke. We quantified whole-brain structural volume changes longitudinally (3-12 months) in stroke participants with ( N = 32) and without aphasia ( N = 59) as assessed by the Token Test at 3 months post-stroke, compared with a healthy control group ( N = 29)...
2022: Brain communications
#11
Elizabeth Williams Louie, Ron Streeter, Melinda Story, Peter V Scrivani, Myra Barrett, Kathleen R Mullen
A neonatal Dutch Warmblood colt was evaluated for inability to stand, incoordination and intention tremor. Despite partial improvement in clinical signs during the first 4 days of hospitalization, neurological deficits remained. Magnetic resonance imaging identified a unilateral infratentorial arachnoid cyst-like lesion with ipsilateral compression and displacement of the cerebellar hemisphere, absent corpus collosum, polymicrogyria, suspect leukoencephalopathy, and noncompressive occipitoatlantal malformation...
May 2022: Journal of Veterinary Internal Medicine
#12
JOURNAL ARTICLE
Maya Alexandri, Bradford Z Reynolds, Hunter Smith, Bradley Michael Golden, Hartmut Gross, Jeffrey A Switzer
BACKGROUND: Many documented secondary neurologic manifestations are associated with COVID-19, including mild peripheral and central nervous system disorders (such as hypo/anosmia, hypo/ageusia, and cranial nerve VII palsy) and severe problems (such as ischemic stroke, Guillain-Barré syndrome, and encephalitis). The list is growing. A new addition is non-alcohol Wernicke's encephalopathy. CASE PRESENTATION: We present the case of a 24-year-old male with no past medical history who developed stroke-like symptoms two days after testing positive for COVID-19...
January 28, 2022: International Journal of Emergency Medicine
#13
REVIEW
Jennifer L Cornish, Asheeta A Prasad
Clinical studies provide fundamental knowledge of substance use behaviors (substance of abuse, patterns of use, relapse rates). The combination of neuroimaging approaches reveal correlation between substance use disorder (SUD) and changes in neural structure, function, and neurotransmission. Here, we review these advances, placing special emphasis on sex specific findings from structural neuroimaging studies of those dependent on alcohol, nicotine, cannabis, psychostimulants, or opioids. Recent clinical studies in SUD analyzing sex differences reveal neurobiological changes that are differentially impacted in common reward processing regions such as the striatum, hippocampus, amygdala, insula, and corpus collosum...
2021: Frontiers in global women's health
#14
JOURNAL ARTICLE
Adam Barsouk, Michael P Baldassari, Omaditya Khanna, Carrie E Andrews, Donald Y Ye, Lohit Velagapudi, Fadi Al Saiegh, Karim Hafazalla, Erica Cunningham, Heli Patel, Kabir Malkani, Evan M Fitchett, Christopher J Farrell, Kevin D Judy
Glioblastoma (GBM) with deep-supratentorial extension (DSE) involving the thalamus, basal ganglia and corpus collosum, poses significant challenges for clinical management. In this study, we present our outcomes in patients who underwent resection of supratentorial GBM with associated involvement of deep brain structures. We conducted a retrospective review of patients who underwent resection of GBM at our institution between 2012 and 2018. A total of 419 patients were included whose pre-operative MRI scans were reviewed...
November 2021: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
#15
JOURNAL ARTICLE
H G Hamidabadi, M N Bojnordi, S Ehsani
IM: Here we used a demyelination model using an injection of Lysophosphatidylcholine )LPC( in the corpus collosum to examine the myelination activity of differentiated oligodendrocytes derived from Human dental pulp stem cells )hDPDSCs( according to a two step induction protocol. METHODS AND MATERIALS: The cells were cultured in DMEM-F12 medium containing 1M Retinoic acid and were treated with 5ng/ml platelet-derived growth factor, 10 ng/ml basic fibroblast growth factor for 8-10 days...
2021: Bratislavské Lekárske Listy
#16
JOURNAL ARTICLE
Xinran Wu, Qunlin Chen, Xi Wang, Zhiting Ren, Dongtao Wei, Jiangzhou Sun, Jie Zhang, Xinyu Liang, Yaya Jiang, Suyu Zhong, Gaolang Gong, Jiang Qiu
Recent neuroimaging studies demonstrate that creativity is related to brain regions across both hemispheres, and the corpus callosum forms the structural basis of inter-hemispheric information exchange. However, the findings regarding the relationship between inter-hemispheric interaction and creativity remain inconsistent, which may be caused by different types of creativity and neural features being adopted. To clarify the inconsistency, and understand how inter-hemispheric interactions are related to different kinds of creativity, we explored the correlation between eight structural measures of the corpus callosum (CC) and two different domains of creativity [verbal creativity (VerC) and visual creativity (VisC)] using a large healthy-adult sample (n = 446)...
November 2021: Brain Structure & Function
#17
JOURNAL ARTICLE
David A Hoagey, Linh T T Lazarus, Karen M Rodrigue, Kristen M Kennedy
Even within healthy aging, vascular risk factors can detrimentally influence cognition, with executive functions (EF) particularly vulnerable. Fronto-parietal white matter (WM) connectivity in part, supports EF and may be particularly sensitive to vascular risk. Here, we utilized structural equation modeling in 184 healthy adults (aged 20-94 years of age) to test the hypotheses that: 1) fronto-parietal WM microstructure mediates age effects on EF; 2) higher blood pressure (BP) and white matter hyperintensity (WMH) burden influences this association...
August 2021: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
#18
JOURNAL ARTICLE
Fady Abayazid, Ke Ding, Karl Zimmerman, Helena Stigson, Mazdak Ghajari
New helmet technologies have been developed to improve the mitigation of traumatic brain injury (TBI) in bicycle accidents. However, their effectiveness under oblique impacts, which produce more strains in the brain in comparison with vertical impacts adopted by helmet standards, is still unclear. Here we used a new method to assess the brain injury prevention effects of 27 bicycle helmets in oblique impacts, including helmets fitted with a friction-reducing layer (MIPS), a shearing pad (SPIN), a wavy cellular liner (WaveCel), an airbag helmet (Hövding) and a number of conventional helmets...
May 10, 2021: Annals of Biomedical Engineering
#19
Kate Lilley, Sandeep Bhuta, Arman Sabet, Simon A Broadley
Hereditary spastic paraplegias (HSP) are phenotypically and genotypically diverse. We describe a unique case of autosomal recessive HSP (ARHSP) diagnosed at age 44 in a patient previously described as having "spinal muscular ataxia" [sic]. Predominant lower motor neuron findings and lack of clinical spasticity reduced suspicion for HSP in early life. The identified SPG11 mutation was novel and the presentation was atypical for HSP in general and SPG11 disease specifically.
November 2020: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
#20
RANDOMIZED CONTROLLED TRIAL
Michael M Francis, Tom A Hummer, Emily Liffick, Jenifer L Vohs, Nikki F Mehdiyoun, Andrew C Visco, Ziyi Yang, Richard J Kovacs, Ying Zhang, Alan Breier
Several lines of evidence have implicated white matter (WM) deficits in schizophrenia, including microstructural alterations from diffusion tensor (DTI) brain imaging studies. It has been proposed that dysregulated inflammatory processes, including heightened activity of circulating lymphocytes, may contribute to WM pathology in this illness. Fingolimod is a sphingosine-1-phosphate (S1P) receptor agonist that is approved for the treatment of relapsing multiple sclerosis (MS). Fingolimod robustly decreases the number of circulating lymphocytes through sequestration of these cells in lymph tissue...
August 2021: Brain Imaging and Behavior
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