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Slippery slope

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https://www.readbyqxmd.com/read/29449776/nkx2-3-a-slippery-slope-from-development-through-inflammation-toward-hematopoietic-malignancies
#1
REVIEW
Dóra Vojkovics, Zoltán Kellermayer, Béla Kajtár, Giovanna Roncador, Áron Vincze, Péter Balogh
The development of peripheral lymphoid tissues from the mesoderm is the result of a complex convergence combining lymphohematopoietic differentiation with the local specification of nonhematopoietic mesenchymal components. Although the various transcriptional regulators with fate-determining effects in diversifying the mobile leukocyte subsets have been thoroughly studied and identified, the tissue-specific determinants promoting the regional differentiation of resident mesenchyme are less understood. Of these factors, various members of the NK-class Nkx paralogues have emerged as key regulators for the organogenesis of spleen and mucosal lymphoid tissues, and recent data have also indicated their involvement in various pathological events, including gut inflammation and hematopoietic malignancies...
2018: Biomarker Insights
https://www.readbyqxmd.com/read/29317518/should-pediatric-euthanasia-be-legalized
#2
Marije Brouwer, Christopher Kaczor, Margaret P Battin, Els Maeckelberghe, John D Lantos, Eduard Verhagen
Voluntary active euthanasia for adults at their explicit request has been legal in Belgium and the Netherlands since 2002. In those countries, acceptance of the practice for adults has been followed by acceptance of the practice for children. Opponents of euthanasia see this as a dangerous slippery slope. Proponents argue that euthanasia is sometimes ethically appropriate for minors and that, with proper safeguards, it should be legally available in appropriate circumstances for patients at any age. In this Ethics Rounds, we asked philosophers from the United States and the Netherlands, and a Dutch pediatrician, to discuss the ethics of legalizing euthanasia for children...
January 9, 2018: Pediatrics
https://www.readbyqxmd.com/read/29306084/traffic-accident-severity-analysis-with-rain-related-factors-using-structural-equation-modeling-a-case-study-of-seoul-city
#3
Jonghak Lee, Junghyo Chae, Taekwan Yoon, Hojin Yang
Weather conditions are strongly correlated with traffic accident severity. In particular, rain-related factors are an important cause of traffic accidents due to the poor visibility and reduced friction resulting from slippery road conditions. This paper presents a systematic approach to analyze the extent to which the rainfall intensity and level of water depth are responsible for traffic accidents using Seoul City, Korea, as a case study. The rainfall and traffic accident data over a nine-year period (from 2007 to 2015) for Seoul were analyzed through Structural Equation Modeling to identify the relationships among variables by handling endogenous and exogenous variables simultaneously...
January 3, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29249919/abortion-and-conscientious-objection-rethinking-conflicting-rights-in-the-mexican-context
#4
Gustavo Ortiz-Millán
Since 2007, when Mexico City decriminalized abortion during the first trimester, a debate has been taking place regarding abortion and the right to conscientious objection (CO). Many people argue that, since the provision of abortions (or "legal terminations of pregnancy" as they are called under Mexico City's law) is now a statutory duty of healthcare personnel there can be no place for "conscientious objection." Others claim that, even if such an objection were to be allowed, it should not be seen as a right, since talk about a right to CO may lead to a slippery slope where we may end up recognizing a right to disobey the law...
2018: Global Bioethics, Problemi di Bioetica
https://www.readbyqxmd.com/read/29108861/a-slippery-slope-on-the-origin-role-and-physiology-of-mucus
#5
Farhan Taherali, Felipe Varum, Abdul W Basit
The mucosa of the gastrointestinal tract, eyes, nose, lungs, cervix and vagina is lined by epithelium interspersed with mucus-secreting goblet cells, all of which contribute to their unique functions. This mucus provides an integral defence to the epithelium against noxious agents and pathogens. However, it can equally act as a barrier to drugs and delivery systems targeting epithelial passive and active transport mechanisms. This review highlights the various mucins expressed at different mucosal surfaces on the human body, and their role in creating a mucoid architecture to protect epithelia with specialized functions...
November 3, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29025882/mucolytics-for-copd-negotiating-a-slippery-slope-towards-proof-of-efficacy
#6
EDITORIAL
Shawn D Aaron
No abstract text is available yet for this article.
October 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28975201/the-slippery-slope-of-legalization-of-physician-assisted-suicide
#7
William G Kussmaul
No abstract text is available yet for this article.
September 19, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28943295/the-slippery-slope-of-hematopoietic-stem-cell-aging
#8
Martin Wahlestedt, David Bryder
The late stages of life, in most species including humans, are associated with a decline in the overall maintenance and health of the organism. This applies also to the hematopoietic system, where aging is not only associated with an increased predisposition for hematological malignancies, but also identified as a strong comorbidity factor for other diseases. Research during the last two decades has proposed that alterations at the level of hematopoietic stem cells (HSCs) might be a root cause for the hematological changes observed with age...
September 21, 2017: Experimental Hematology
https://www.readbyqxmd.com/read/28914219/-euthanasia-and-advanced-dementia
#9
B Keizer
Somewhere around 1975 there was a shift in our perception of suffering that is soon followed by death: it seemed a good idea to skip this unhappy stage of life. A complicated national debate arose, and continues to this day, about whether a life may be prematurely terminated in cases of insoluble misery. Legislation came into effect 2002, after 30 years of deliberation, and the rest of the world looked on in horror. England, in particular, liked to point out that the Dutch were on a very slippery slope.
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28767539/medicolegal-investigations-into-deaths-due-to-crush-asphyxia-after-tractor-side-rollovers
#10
Carlo Moreschi, Ugo Da Broi, Antonia Fanzutto, Sirio Cividino, Rino Gubiani, Gianfranco Pergher
Farm tractors are large, heavy, powerful vehicles with a high center of gravity. When driven carelessly on sloping, irregular, or slippery ground, tractors can overturn sideways and cause the death by crush asphyxia of the driver or passengers, especially if appropriate safety equipment is not fitted or used. The aim of this review is to focus on the diagnostic difficulties with which coroners and forensic pathologists have to cope when a confirmation of crush asphyxia after tractor side rollover is required by judicial authorities...
December 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28728786/the-slippery-slope-of-nonoperative-therapy-in-early-stage-lung-cancer
#11
EDITORIAL
Lara W Schaheen, Jonathan D'Cunha
No abstract text is available yet for this article.
September 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28716621/health-care-professionals-attitudes-about-physician-assisted-death-an-analysis-of-their-justifications-and-the-roles-of-terminology-and-patient-competency
#12
Derek W Braverman, Brian S Marcus, Paul G Wakim, Mark R Mercurio, Gary S Kopf
CONTEXT: Health care professionals (HCPs) are crucial to physician-assisted death (PAD) provision. OBJECTIVES: To quantitatively assess the favorability of justifications for or against PAD legalization among HCPs, the effect of the terms "suicide" and "euthanasia" on their views and their support for three forms of PAD. METHODS: Our questionnaire presented three cases: physician-assisted suicide, euthanasia for a competent patient, and euthanasia for an incompetent patient with an advance directive for euthanasia...
October 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28537093/facilitating-resident-community-in-nursing-homes-a-slippery-slope-an-analysis-on-collectivistic-and-individualistic-approaches
#13
Gudmund Ågotnes, Christine Øye
Residents in nursing homes are old and frail and are dependent on constant care, medical, or otherwise, by trained professionals. But they are also social beings, secluded in an institutional setting which is both total and foreign. In this setting, most of the residents most of the time must relate to other residents: other residents are the nursing home residents' peers, companions, and perhaps even significant others. In this article, we will discuss how resident communities in nursing homes are influenced by the approaches of nursing home staff...
May 1, 2017: Health (London)
https://www.readbyqxmd.com/read/28525526/critical-analysis-of-the-council-for-international-organizations-of-medical-sciences-2016-international-guidelines-for-health-related-research-involving-humans
#14
REVIEW
Miguel Hugo Kottow Lang
This paper presents a preliminary discussion of the Council for International Organizations of Medical Sciences (CIOMS), recently issued “International Ethical Guidelines for Health-related Research Involving Humans” (2016) that acknowledges the document’s declared concern of the protection of human subjects and awareness of their needs and interests in “low-resource settings”. Nevertheless, guideline recommendations present exceptional situations –vulnerability, mental incompetence- wherein voluntary and consented participation may be reduced or omitted under three concurrent conditions: compelling scientific value, the need to include persons that will not benefit directly from participation, exposure to minimal or slight risks...
May 15, 2017: Medwave
https://www.readbyqxmd.com/read/28315062/expansion-of-criteria-for-liver-transplantation-in-hepatocellular-carcinoma-better-patient-selection-or-a-slippery-slope
#15
EDITORIAL
Adam C Yopp, Jorge A Marrero, Amit G Singal
No abstract text is available yet for this article.
July 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28210521/the-right-to-die-in-chronic-disorders-of-consciousness-can-we-avoid-the-slippery-slope-argument
#16
REVIEW
Rocco Salvatore Calabrò, Antonino Naro, Rosaria De Luca, Margherita Russo, Lory Caccamo, Alfredo Manuli, Alessia Bramanti, Placido Bramanti
Managing individuals with chronic disorders of consciousness raises ethical questions about the appropriateness of maintaining life-sustaining treatments and end-of-life decisions for those who are unable to make decisions for themselves. For many years, the positions fostering the "sanctity" of human life (i.e., life is inviolable in any case) have led to maintaining life-sustaining treatments (including artificial nutrition and hydration) in patients with disorders of consciousness, allowing them to live for as long as possible...
November 2016: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/28126658/pluripotency-of-embryo-derived-stem-cells-from-rodents-lagomorphs-and-primates-slippery-slope-terrace-and-cliff
#17
REVIEW
Pierre Savatier, Pierre Osteil, Patrick P L Tam
The diverse cell states and in vitro conditions for the derivation and maintenance of the mammalian embryo-derived pluripotent stem cells raise the questions of whether there are multiple states of pluripotency of the stem cells of each species, and if there are innate species-specific variations in the pluripotency state. We will address these questions by taking a snapshot of our knowledge of the properties of the pluripotent stem cells, focusing on the maintenance of pluripotency and inter-conversion of the different types of pluripotent stem cells from rodents, lagomorphs and primates...
March 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28109423/moving-beyond-the-debate-over-restricting-sugary-drinks-in-the-supplemental-nutrition-assistance-program
#18
EDITORIAL
Marlene B Schwartz
To address the dual problem of food insecurity and poor nutrition, the U.S. Department of Agriculture has recently revised the nutrition standards for nearly all of its federal food programs to align with the Dietary Guidelines for Americans. One notable exception is the Supplemental Nutrition Assistance Program (SNAP). Policy proposals to restrict SNAP benefits based on nutrition quality (e.g., excluding sugary drinks) have generated controversy and have polarized previous research and advocacy allies. This essay presents many of the issues that have emerged, which include challenges about the feasibility, justification, and effectiveness of restricting benefits; the risk of a slippery slope; concerns about participant dignity; and finally, distrust about the motives behind promoting and opposing a policy change...
February 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28080302/the-road-to-bribery-and-corruption
#19
Nils C Köbis, Jan-Willem van Prooijen, Francesca Righetti, Paul A M Van Lange
Major forms of corruption constitute a strong threat to the functioning of societies. The most frequent explanation of how severe corruption emerges is the slippery-slope metaphor-the notion that corruption occurs gradually. While having widespread theoretical and intuitive appeal, this notion has barely been tested empirically. We used a recently developed paradigm to test whether severely corrupt acts happen gradually or abruptly. The results of four experimental studies revealed a higher likelihood of severe corruption when participants were directly given the opportunity to engage in it (abrupt) compared with when they had previously engaged in minor forms of corruption (gradual)...
March 2017: Psychological Science
https://www.readbyqxmd.com/read/28062650/euthanasia-embedded-in-palliative-care-responses-to-essentialistic-criticisms-of-the-belgian-model-of-integral-end-of-life-care
#20
Jan L Bernheim, Kasper Raus
The Belgian model of 'integral' end-of-life care consists of universal access to palliative care (PC) and legally regulated euthanasia. As a first worldwide, the Flemish PC organisation has embedded euthanasia in its practice. However, some critics have declared the Belgian-model concepts of 'integral PC' and 'palliative futility' to fundamentally contradict the essence of PC. This article analyses the various essentialistic arguments for the incompatibility of euthanasia and PC. The empirical evidence from the euthanasia-permissive Benelux countries shows that since legalisation, carefulness (of decision making) at the end of life has improved and there have been no significant adverse 'slippery slope' effects...
August 2017: Journal of Medical Ethics
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