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https://www.readbyqxmd.com/read/29220360/substitutions-of-prp-n-terminal-histidine-residues-modulate-scrapie-disease-pathogenesis-and-incubation-time-in-transgenic-mice
#1
Sabina Eigenbrod, Petra Frick, Uwe Bertsch, Gerda Mitteregger-Kretzschmar, Janina Mielke, Marko Maringer, Niklas Piening, Alexander Hepp, Nathalie Daude, Otto Windl, Johannes Levin, Armin Giese, Vignesh Sakthivelu, Jörg Tatzelt, Hans Kretzschmar, David Westaway
Prion diseases have been linked to impaired copper homeostasis and copper induced-oxidative damage to the brain. Divalent metal ions, such as Cu2+ and Zn2+, bind to cellular prion protein (PrPC) at octapeptide repeat (OR) and non-OR sites within the N-terminal half of the protein but information on the impact of such binding on conversion to the misfolded isoform often derives from studies using either OR and non-OR peptides or bacterially-expressed recombinant PrP. Here we created new transgenic mouse lines expressing PrP with disrupted copper binding sites within all four histidine-containing OR's (sites 1-4, H60G, H68G, H76G, H84G, "TetraH>G" allele) or at site 5 (composed of residues His-95 and His-110; "H95G" allele) and monitored the formation of misfolded PrP in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/29215662/-validation-of-the-scale-of-hope-in-terminal-illness-for-relatives-brief-version-shti-b-validity-and-reliability-analysis
#2
M Villacieros Durban, J C Bermejo, H Hassoun
BACKGROUND: Bermejo and Villacieros' Scale of Hope in Terminal Disease (SHTD) specifically collects meanings of hope facing terminal disease, including considerations relating to psycho-emotional support and that have a transcendental sense. The objective of this paper is to validate the SHTD abbreviated and rephrased to adapt all the items to a single domain. METHODS: Starting from the published SHTD, an exploratory factor analysis (EFA) was carried out with a sample of 177 valid questionnaires...
December 7, 2017: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/29213079/human-cd26high-t-cells-elicit-tumor-immunity-against-multiple-malignancies-via-enhanced-migration-and-persistence
#3
Stefanie R Bailey, Michelle H Nelson, Kinga Majchrzak, Jacob S Bowers, Megan M Wyatt, Aubrey S Smith, Lillian R Neal, Keisuke Shirai, Carmine Carpenito, Carl H June, Michael J Zilliox, Chrystal M Paulos
CD8+ T lymphocytes mediate potent immune responses against tumor, but the role of human CD4+ T cell subsets in cancer immunotherapy remains ill-defined. Herein, we exhibit that CD26 identifies three T helper subsets with distinct immunological properties in both healthy individuals and cancer patients. Although CD26neg T cells possess a regulatory phenotype, CD26int T cells are mainly naive and CD26high T cells appear terminally differentiated and exhausted. Paradoxically, CD26high T cells persist in and regress multiple solid tumors following adoptive cell transfer...
December 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/29202863/a-novel-family-dignity-intervention-fdi-for-enhancing-and-informing-holistic-palliative-care-in-asia-study-protocol-for-a-randomized-controlled-trial
#4
Andy Hau Yan Ho, Josip Car, Moon-Ho Ringo Ho, Geraldine Tan-Ho, Ping Ying Choo, Paul Victor Patinadan, Poh Heng Chong, Wah Ying Ong, Gilbert Fan, Yee Pin Tan, Robert A Neimeyer, Harvey M Chochinov
BACKGROUND: The lack of a holistic approach to palliative care can lead to a fractured sense of dignity at the end of life, resulting in depression, hopelessness, feelings of being a burden to others, and the loss of the will to live among terminally ill patients. Building on the clinical foundation of Dignity Therapy, together with the empirical understanding of dignity-related concerns of Asian families facing terminal illness, a novel Family Dignity Intervention (FDI) has been developed for Asian palliative care...
December 4, 2017: Trials
https://www.readbyqxmd.com/read/29196477/usage-of-unscheduled-hospital-care-by-homeless-individuals-in-dublin-ireland-a-cross-sectional-study
#5
Clíona Ní Cheallaigh, Sarah Cullivan, Jess Sears, Ann Marie Lawlee, Joe Browne, Jennifer Kieran, Ricardo Segurado, Austin O'Carroll, Fiona O'Reilly, Donnacha Creagh, Colm Bergin, Rose Anne Kenny, Declan Byrne
OBJECTIVES: Homeless people lack a secure, stable place to live and experience higher rates of serious illness than the housed population. Studies, mainly from the USA, have reported increased use of unscheduled healthcare by homeless individuals.We sought to compare the use of unscheduled emergency department (ED) and inpatient care between housed and homeless hospital patients in a high-income European setting in Dublin, Ireland. SETTING: A large university teaching hospital serving the south inner city in Dublin, Ireland...
December 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/29192737/dreams-and-illusions-in-adolescents-with-terminal-cancer
#6
Laura Veneroni, Andrea Ferrari, Tullio Proserpio, Elena Pagani Bagliacca, Marta Podda, Maura Massimino, Carlo Alfredo Clerici
Being diagnosed with cancer in adolescence generally has important emotional consequences: adolescent cancer patients need to be seen as special cases with particular medical and psychosocial needs. This is especially true when a young patient is faced with a progressive, incurable disease. Herein, we report the story of a 17-year-old girl with a metastatic refractory soft tissue sarcoma who tells her dream to the psychologist of the ward. Telling this narrative is the opportunity to discuss the complex topic of how adolescent cancer patients adapt to the terminal stage of their disease; for example, the patient needs to talk to someone about their fear of dying; the healthcare operators need to be able properly listen and communicate; the patient's trust in the future despite their clinical condition; the necessity to leave space for hope; the useful role of the imagination sphere; the issue of whether and how to tell a person who is terminally ill the truth about their condition...
November 21, 2017: Tumori
https://www.readbyqxmd.com/read/29183249/truth-telling-decision-making-and-ethics-among-cancer-patients-in-nursing-practice-in-china
#7
Dong-Lan Ling, Hong-Jing Yu, Hui-Ling Guo
BACKGROUND: Truth-telling toward terminally ill patients is a challenging ethical issue in healthcare practice. However, there are no existing ethical guidelines or frameworks provided for Chinese nurses in relation to decision-making on truth-telling of terminal illness and the role of nurses thus is not explicit when encountering this issue. OBJECTIVES: The intention of this paper is to provide ethical guidelines or strategies with regards to decision-making on truth-telling of terminal illness for Chinese nurses...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/29178042/correction-to-terminal-weaning-or-immediate-extubation-for-withdrawing-mechanical-ventilation-in-critically-ill-patients-the-arreve-observational-study
#8
René Robert, Amélie Le Gouge, Nancy Kentish-Barnes, Alice Cottereau, Bruno Giraudeau, Mélanie Adda, Djillali Annane, Juliette Audibert, François Barbier, Patrick Bardou, Simon Bourcier, Jeremy Bourenne, Alexandre Boyer, François Brenas, Vincent Das, Arnaud Desachy, Jérôme Devaquet, Marc Feissel, Frédérique Ganster, Maïté Garrouste-Orgeas, Guillaume Grillet, Olivier Guisset, Rebecca Hamidfar-Roy, Anne-Claire Hyacinthe, Sebastien Jochmans, Mercé Jourdain, Alexandre Lautrette, Nicolas Lerolle, Olivier Lesieur, Fabien Lion, Philippe Mateu, Bruno Megarbane, Sybille Merceron, Emmanuelle Mercier, Jonathan Messika, Paul Morin-Longuet, Bénédicte Philippon-Jouve, Jean-Pierre Quenot, Anne Renault, Xavier Repesse, Jean-Philippe Rigaud, Ségolène Robin, Antoine Roquilly, Amélie Seguin, Didier Thevenin, Patrice Tirot, Isabelle Vinatier, Elie Azoulay, Jean Reignier
Correction to: Intensive Care Med (2017) DOI 10.1007/s00134-017-4891-0.
November 24, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/29176085/maintaining-compassion-for-the-suffering-terminal-patient-while-preserving-life-an-orthodox-jewish-approach
#9
Daniel Eisenberg
Regardless of one's religious beliefs, the process of making end-of-life decisions is inherently difficult and emotionally trying. The caregiver, family member, or friend is faced with making heart-wrenching decisions for loved ones where the line between support and cruelty may feel blurred. By evaluating the process by which traditional Judaism harmonizes the apparently conflicting obligations of the caregiver in end-of-life scenarios through three practical cases, all people can gain insight into managing this delicate balancing act and may develop generalizable approaches that recognize and appreciate the particularities of each patient's needs...
2017: Perspectives in Biology and Medicine
https://www.readbyqxmd.com/read/29173079/what-influences-intentions-to-request-physician-assisted-euthanasia-or-continuous-deep-sedation
#10
Anne-Lore Scherrens, Marc Roelands, L Van den Block, B Deforche, Luc Deliens, J Cohen
The increasing prevalence of euthanasia in Belgium has been linked to changing attitudes. Using National health survey data (N = 9651), we investigated Belgian adults' intention to ask a physician for euthanasia or continuous deep sedation in the hypothetical scenario of a terminal illness, and examined its connection to sociodemographic and health characteristics. Respectively, 38.3% and 25.8% could envisage asking for euthanasia and continuous deep sedation. Those with very bad to fair subjective health and with depression more likely had an intention to ask for euthanasia, which suggests need for attention in the evaluation of requests from specific patient groups...
November 27, 2017: Death Studies
https://www.readbyqxmd.com/read/29172993/a-soup-service-for-advanced-digestive-cancer-patients-with-severe-anorexia-in-palliative-care
#11
Hideaki Kawabata, Naoki Kakihara, Yoko Nishitani, Kota Asano, Mariko Nose, Asami Takanashi, Eiichiro Kanda, Masako Nishimura, Eiko Tokunaga, Ayako Matsurugi, Keiko Fujimura, Masanori Nishikawa, Chiaki Taga, Osamu Ikawa, Makiko Yamaguchi, Katsuhiko Masuda
BACKGROUND/AIMS: The palliative care team (PCT), nutrition support team (NST), and department of nutrition in our hospital developed a special soup service for patients with terminal cancer. We evaluated the usefulness of this soup service for improving the mood in patients with advanced digestive cancer with severe anorexia. MATERIAL AND METHODS: We retrospectively reviewed the clinical data of 18 patients with advanced cancer originating in digestive organs who received soup service at our institution between 2015 and 2016...
November 27, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29167039/psychological-and-psychiatric-symptoms-of-terminally-ill-patients-with-cancer-and-their-family-caregivers-in-the-home-care-setting-a-nation-wide-survey-from-the-perspective-of-bereaved-family-members-in-japan
#12
Makoto Kobayakawa, Asao Ogawa, Michiko Konno, Akiko Kurata, Jun Hamano, Tatsuya Morita, Yoshiyuki Kizawa, Satoru Tsuneto, Yasuo Shima, Maho Aoyama, Mitsunori Miyashita
OBJECTIVE: The psychological and psychiatric symptoms of terminally ill cancer patients are highly problematic and have been associated with greater burden among caregivers. Until now, the extent of these problems in the home care setting was unclear. METHODS: This retrospective study was conducted as part of a nationwide survey from the perspective of bereaved family members in Japan (J-HOPE3). The bereaved family members rated the symptoms of delirium and suicidal ideation of patients with cancer, and the sleeplessness and depressed mood of family caregivers utilizing home care services in the one month before the patients' deaths...
December 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29166958/insights-into-the-factors-associated-with-achieving-the-preference-of-home-death-in-terminal-cancer-a-national-population-based-study
#13
Finian Bannon, Victoria Cairnduff, Deirdre Fitzpatrick, Janine Blaney, Barbara Gomes, Anna Gavin, Conan Donnelly
OBJECTIVES: Most terminally ill cancer patients prefer to die at home, yet only a minority are able to achieve this. Our aim was to investigate the factors associated with cancer patients achieving their preference to die at home. METHODS: This study took the form of a mortality followback, population-based, observational survey of the relatives of deceased cancer patients in Northern Ireland. Individuals who registered the death of a friend or relative (aged ≥ 18 years) between 1 December 2011 and 31 May 2012, where the primary cause of death was cancer (ICD10: C00-D48), who were invited to take part...
November 23, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/29166873/mortality-patterns-and-risk-among-older-men-and-women-with-intellectual-disability-a-swedish-national-retrospective-cohort-study
#14
Nawi Ng, Eva Flygare Wallén, Gerd Ahlström
BACKGROUND: Sweden has closed all institutions and imposed legislation to ensure service and support for individuals with intellectual disability (ID). Understanding mortality among older individuals with ID is essential to inform development of health promotion and disease control strategies. We investigated patterns and risk of mortality among older adults with ID in Sweden. METHODS: This retrospective cohort study compared older adults aged 55 years and older with ID with a control population...
November 22, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29166565/hospital-based-physicians-intubation-decisions-and-associated-mental-models-when-managing-a-critically-and-terminally-ill-older-patient
#15
Shannon Haliko, Julie Downs, Deepika Mohan, Robert Arnold, Amber E Barnato
BACKGROUND: Variation in the intensity of acute care treatment at the end of life is influenced more strongly by hospital and provider characteristics than patient preferences. OBJECTIVE: We sought to describe physicians' mental models (i.e., thought processes) when encountering a simulated critically and terminally ill older patient, and to compare those models based on whether their treatment plan was patient preference-concordant or preference-discordant. METHODS: Seventy-three hospital-based physicians from 3 academic medical centers engaged in a simulated patient encounter and completed a mental model interview while watching the video recording of their encounter...
November 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/29164567/role-of-mll3-in-regulating-cardiac-stem-cells-following-cardiac-cachexia
#16
J-X Zhao, H-X Zhang, B Li, Q-X Fan, S-Z Xue, M Zhang, C-Q Ke
OBJECTIVE: Cardiac cachexia is a form of serious illness that results with terminal stage of heart failure. It is associated with unreasonable weight loss and muscle loss with poor prognosis. Cardiac stem cells play a major role in repairing, damaged cardiac tissue and they are regulated by different mechanisms. In the present study, we investigated the role of MLL3 in regulating cardiac stem cells following cardiac cachexia. MATERIALS AND METHODS: To effectively study the cardiac cachexia, we established a Dahl rat model that produces symptoms similar to cachexia...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29163464/nlrp3-inflammasome-mediates-dormant-neutrophil-recruitment-following-sterile-lung-injury-and-protects-against-subsequent-bacterial-pneumonia-in-mice
#17
Xiaoli Tian, He Sun, Amy-Jo Casbon, Edward Lim, Kevin P Francis, Judith Hellman, Arun Prakash
Sterile lung injury is an important clinical problem that complicates the course of severely ill patients. Interruption of blood flow, namely ischemia-reperfusion (IR), initiates a sterile inflammatory response in the lung that is believed to be maladaptive. The rationale for this study was to elucidate the molecular basis for lung IR inflammation and whether it is maladaptive or beneficial. Using a mouse model of lung IR, we demonstrate that sequential blocking of inflammasomes [specifically, NOD-, LRR-, and pyrin domain-containing 3 (NLRP3)], inflammatory caspases, and interleukin (IL)-1β, all resulted in an attenuated inflammatory response...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29156921/sexual-healthcare-for-cancer-patients-receiving-palliative-care-a-narrative-review
#18
Katie Wang, Krista Ariello, Matthew Choi, Angela Turner, Bo Angela Wan, Caitlin Yee, Leigha Rowbottom, Rachel Macdonald, Henry Lam, Leah Drost, Edward Chow
Palliative care aims to improve quality of life (QoL) for patients and families and does so by addressing issues not limited to pathology, but other symptoms that may be debilitating to patient experience and QoL. Despite sexual health being an important aspect of life for many patients, it is often omitted in clinical practice. This review summarizes published primary studies to explore the prevalence and importance of incorporating sexual health in the symptom screening and assessments of palliative patients, to identify current interventions that are implemented to address sexual health issues, and identify the barriers that health care professionals (HCPs) and patients may encounter which may prevent sexual health discussions...
November 15, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29156908/enhanced-psychosocial-support-as-important-component-of-neuro-palliative-service
#19
Kwok-Ying Chan, Man-Lui Chan
There are unmet palliative care (PC) needs for psychosocial and spiritual distress of neurology patients such as bad stroke as well as in chronic neurodegenerative diseases. As such, psychosocial support to both patients and their caregivers should be enhanced in order to provide comprehensive neuro-PC. The first step in developing this type of support/program was to recognize the main psychosocial care needs of the population. Once these were determined, a program was specifically devised to meet those needs as efficiently and effectively as possible...
September 7, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29152418/generation-and-characterization-of-cross-neutralizing-human-monoclonal-antibody-against-4-serotypes-of-dengue-virus-without-enhancing-activity
#20
Subenya Injampa, Nataya Muenngern, Chonlatip Pipattanaboon, Surachet Benjathummarak, Khwanchit Boonha, Hathairad Hananantachai, Waranya Wongwit, Pongrama Ramasoota, Pannamthip Pitaksajjakul
Background: Dengue disease is a leading cause of illness and death in the tropics and subtropics. Most severe cases occur among patients secondarily infected with a different dengue virus (DENV) serotype compared with that from the first infection, resulting in antibody-dependent enhancement activity (ADE). Our previous study generated the neutralizing human monoclonal antibody, D23-1B3B9 (B3B9), targeting the first domain II of E protein, which showed strong neutralizing activity (NT) against all four DENV serotypes...
2017: PeerJ
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