Read by QxMD icon Read

eosinophilic renal cell neoplasms

Stephen M Bonsib, Christie Boils, Neriman Gokden, David Grignon, Xin Gu, John P T Higgins, Xavier Leroy, Jesse K McKenney, Samih H Nasr, Carrie Phillips, Ankur R Sangoi, Jon Wilson, Ping L Zhang
Tuberous sclerosis complex (TSC) results from mutation of TSC1 or TSC2 that encode for hamartin and tuberin. It affects the kidneys often in advance of extra-renal stigmata. We studied 14 TSC cases, and 4 possible TSC cases with multiple angiomyolipomas (AMLs) for hamartin and tuberin protein expression to determine if the staining profile could predict mutation status or likelihood of TSC with renal-limited disease. The 18 cases included 15 nephrectomies and 1 section of 6 TSC-associated renal cell carcinomas (RCC)...
April 30, 2016: Pathology, Research and Practice
Maria Pané Foix, Ana Dunatov, Petr Martinek, Enric Condom Mundó, Saul Suster, Maris Sperga, Jose I Lopez, Monika Ulamec, Stela Bulimbasic, Delia Perez Montiel, Reza Alaghehbandan, Kvetoslava Peckova, Krystina Pivovarcikova, Daum Ondrej, Pavla Rotterova, Faruk Skenderi, Kristyna Prochazkova, Martin Dusek, Milan Hora, Michal Michal, Ondrej Hes
Chromophobe renal cell carcinoma (ChRCC) is typically composed of large leaf-like cells and smaller eosinophilic cells arranged in a solid-alveolar pattern. Eosinophilic, adenomatoid/pigmented, or neuroendocrine variants have also been described. We collected 10 cases of ChRCC with a distinct multicystic pattern out of 733 ChRCCs from our registry, and subsequently analyzed these by morphology, immunohistochemistry, and array comparative genomic hybridization. Of the 10 patients, 6 were males with an age range of 50-89 years (mean 68, median 69)...
September 15, 2016: Virchows Archiv: An International Journal of Pathology
Pedram Argani, Victor E Reuter, Lei Zhang, Yun-Shao Sung, Yi Ning, Jonathan I Epstein, George J Netto, Cristina R Antonescu
Renal cell carcinomas (RCCs) with the t(6;11)(p21;q12) chromosome translocation are low-grade RCC which often occur in young patients. They typically feature an unusual biphasic morphology characterized by nests of larger epithelioid cells surrounding intraluminal collections of smaller cells clustered around basement membrane material. The t(6;11)(p21;q12) translocation fuses the Alpha (MALAT1) gene with the TFEB transcription factor gene, resulting in upregulated expression of intact native TFEB that drives the aberrant expression of melanocytic markers which is a hallmark of this distinctive neoplasm...
November 2016: American Journal of Surgical Pathology
Chi-Fei Kao, Jiun-Liang Chen, Wen-Tien Tsao, An-Hsing Lee, Chen-Hsuan Liu, Fun-In Wang
A 5-year-old male captive corn snake (Pantherophis guttatus) with caudal coelomic swelling was admitted for surgical treatment. Laparotomy revealed a 5 × 4 × 2.5 cm, firm, expansile, irregularly shaped mass arising from the middle portion of the right kidney with a mild lobulated pattern and mottled white-to-tan. Microscopically, the mass was composed of numerous bizarre angulated tubules of polygonal neoplastic cells separated by a scirrhous stroma with remarkable heterophilic infiltrates. The neoplastic cells were nonciliated and mucin secreting, with abundant brightly eosinophilic cytoplasm...
September 2016: Journal of Veterinary Diagnostic Investigation
A S Konstantinov, K V Shelekhova
Ectopic adrenal cortical neoplasms are extremely rare. The authors describe their own case of intradural, extramedullary conus medullaris adenoma that occurred in a 55-year-old woman, which was clinically accompanied by lumbar pains, left leg numbness, and left foot weakness during 10 years. The mass was histologically composed of rounded and polygonal cell fields with rounded, regular nuclei and abundant eosinophilic and clear cytoplasm. There were no necroses or mitoses. The cells were immunohistochemically positive for cytokeratin AE1/3, vimentin, inhibin-α, melan-A, and synaptophysin...
May 2016: Arkhiv Patologii
Jiaju Liu, Zhengming Su, Yifan Li, Duqun Chen, Liangchao Ni, Xiangming Mao, Shangqi Yang, Yongqing Lai
Xp11.2 translocation/transcription factor enhancer 3 (TFE3) fusion gene associated with renal cell carcinoma (Xp11.2 translocation RCC) is rare and occurs predominantly in children and adolescents. The current study reports the case of a 14-year-old male with Xp11.2 translocation RCC, who presented with chest pain that had persisted for 1 month. A solid neoplasm was located in the left kidney of the patient. Contrast-enhanced computed tomography revealed the presence of a solid mass in the kidney, with uneven enhancement...
March 2016: Oncology Letters
Wei Zhang, Kejia Wang, Wenjuan Yu, Yan Liu, Jing Chu, Yanxia Jiang, Yujun Li
OBJECTIVE: To study the immunohistochemical expression of S100A1, GLUT-1 and Cavolin-1 and its diagnostic significance in renal tumors with oncocytic features. METHODS: Tissue microarray and immunohistochemical staining for S100A1, GLUT-1 and Cavolin-1 were carried out in 59 cases of renal tumors with oncocytic features, including 19 cases of renal oncocytoma, 15 cases of clear cell renal cell carcinoma (CCRCC) with eosinophilic cells, 11 cases of eosinophilic variant of chromophobe renal cell carcinoma, 7 cases of oncocytic papillary renal cell carcinoma and 7 cases of epithelioid angiomyolipoma...
November 2015: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Shilpy Joshi, Denis Tolkunov, Hana Aviv, Abraham A Hakimi, Ming Yao, James J Hsieh, Shridar Ganesan, Chang S Chan, Eileen White
Oncocytomas are predominantly benign neoplasms possessing pathogenic mitochondrial mutations and accumulation of respiration-defective mitochondria, characteristics of unknown significance. Using exome and transcriptome sequencing, we identified two main subtypes of renal oncocytoma. Type 1 is diploid with CCND1 rearrangements, whereas type 2 is aneuploid with recurrent loss of chromosome 1, X or Y, and/or 14 and 21, which may proceed to more aggressive eosinophilic chromophobe renal cell carcinoma (ChRCC)...
December 1, 2015: Cell Reports
Li Yan Khor, Puay Hoon Tan
Incidental small renal masses identified on imaging are increasingly investigated via needle core or fine needle aspiration biopsies with limited material provided for rendering a diagnosis. Lesions with a prominent eosinophilic or oncocytic cell presence showing morphologic overlap between well-known eosinophilic neoplasms are challenging to diagnose. We review the range of known benign and malignant eosinophilic renal neoplasms and their immunoprofiles to elucidate a useful panel of stains that may assist the pathologist in making an accurate diagnosis...
February 2016: Urologic Clinics of North America
Fadl H Veerankutty, Varghese Yeldho, Shabeer Ali Tu, B Venugopal, Krishnan Sarojam Manoj, C Vidhya
Pancreatic hepatoid carcinoma (HC) is an extremely uncommon neoplasm of pancreas that resembles hepatocellular carcinoma (HCC). We report a case of incidentally detected pancreatic HC combined with a serous microcystic cystadenoma, in a 47-year-old man, while he was being evaluated for renal calculi. Contrast enhanced computed tomography (CECT) of abdomen revealed a lesion with mild heterogeneous enhancement in the tail of pancreas and another proximal lesion having moderate enhancement, and a calculus in the neck of gallbladder...
October 2015: Hepatobiliary Surgery and Nutrition
Andrey Bychkov, Pichet Sampatanukul
Metastases to the breast are uncommon, accounting for 0.5% of breast tumors, and most of them are originated from lymphoma, melanoma and carcinomas of various organs. Alveolar soft part sarcoma (ASPS) is a very rare neoplasm that is usually found in the lower extremities. Lungs are the common site of dissemination and may represent initial manifestation of disease. We report a clinically unsuspected case of ASPS presenting as a breast metastasis in a 25-year-old woman. The patient's medical history was notable for a thyroid cancer treated by surgery and radioiodine ablation 2 years ago...
2015: International Journal of Clinical and Experimental Pathology
Qiu Rao, Qin Shen, Qiu-yuan Xia, Zi-yu Wang, Biao Liu, Shan-shan Shi, Qun-li Shi, Hong-lin Yin, Bo Wu, Sheng-bing Ye, Li Li, Jie-Yu Chen, Min-hong Pan, Qing Li, Rui Li, Xuan Wang, Ru-song Zhang, Bo Yu, Heng-hui Ma, Zhen-feng Lu, Xiao-jun Zhou
An increasing number of TFE3 rearrangement-associated tumors, such as TFE3 rearrangement-associated perivascular epithelioid cell tumors (PEComas), melanotic Xp11 translocation renal cancers, and melanotic Xp11 neoplasms, have recently been reported. We examined 12 such cases, including 5 TFE3 rearrangement-associated PEComas located in the pancreas, cervix, or pelvis and 7 melanotic Xp11 translocation renal cancers, using clinicopathologic, immunohistochemical, and molecular analyses. All the tumors shared a similar morphology, including a purely nested or sheet-like architecture separated by a delicate vascular network, purely epithelioid cells displaying a clear or granular eosinophilic cytoplasm, a lack of papillary structures and spindle cell or fat components, uniform round or oval nuclei containing small visible nucleoli, and, in most cases (11/12), melanin pigmentation...
September 2015: American Journal of Surgical Pathology
Youssef Mahdi, Kaoutar Znati, Ali Iken, Zakiya Bernoussi, Fouad Zouaidia, Ahmed Jahid, Yassine Nouini, Najat Mahassini
INTRODUCTION: The World Health Organization defines epithelioid angiomyolipoma as a potentially malignant mesenchymal neoplasm characterized by proliferation of predominantly epithelioid cells and as closely related to the triphasic (classic) angiomyolipoma. It can be benign, potentially aggressive or malignant. The pathologist's role is crucial in making a positive diagnosis, providing appropriate patient management and assessing prognosis. In this report, we present a case of a patient with an epithelioid angiomyolipoma and hydatid cyst association...
2015: Journal of Medical Case Reports
Kunal Malik, Parth Patel, Jin Chen, Amor Khachemoune
Cutaneous leiomyomas (CLs) are rare, sporadic, or inherited tumors of smooth muscle origin associated with various disorders. Hereditary leiomyomatosis and renal cell cancer (HLRCC) is the primary tumor predisposition syndrome associated with inherited CLs, affecting 180 families worldwide, with significant mortality. CLs are subdivided into piloleiomyomas, genital leiomyomas, and angioleiomyomas based on their smooth muscle of origin, as well as their clinicopathologic features. Piloleiomyomas, derived from arrector pili muscle, are solitary or multiple firm papulonodules located typically on the extremities and trunk; genital leiomyomas, derived from dartoic, vulvar, or mammary smooth muscle, are solitary papulonodules or pedunculated papules located on the scrotum, vulva, or nipple; and angioleiomyomas, which include solid, cavernous, or venous subtypes, are derived from the tunica media of small arteries and veins and typically present on the extremities...
February 2015: American Journal of Clinical Dermatology
Malcolm Hayes, Kvetoslava Peckova, Petr Martinek, Milan Hora, Kristyna Kalusova, Lubomir Straka, Ondrej Daum, Bohuslava Kokoskova, Pavla Rotterova, Kristyna Pivovarčikova, Jindrich Branzovsky, Magdalena Dubova, Pavla Vesela, Michal Michal, Ondrej Hes
Xp11.2-translocation renal carcinoma (TRCC) is suspected when a renal carcinoma occurs in young patients, patients with a prior history of exposure to chemotherapy and when the neoplasm has morphological features suggestive of that entity. We retrieved 20 renal tumours (from 17,500 archival cases) of which morphology arose suspicion for TRCC. In nine cases, TFE3 translocation was confirmed by fluorescence in situ hybridisation analysis. In 9 of the remaining 11 TRCC-like cases (7 male, 4 female, aged 22-84 years), material was available for further study...
March 2015: Virchows Archiv: An International Journal of Pathology
Oleksandr N Kryvenko, Merce Jorda, Pedram Argani, Jonathan I Epstein
CONTEXT: Eosinophilic renal neoplasms include a spectrum of solid and papillary tumors ranging from indolent benign oncocytoma to highly aggressive malignancies. Recognition of the correct nature of the tumor, especially in biopsy specimens, is paramount for patient management. OBJECTIVE: To review the diagnostic approach to eosinophilic renal neoplasms with light microscopy and ancillary techniques. DATA SOURCES: Review of the published literature and personal experience...
November 2014: Archives of Pathology & Laboratory Medicine
Satoshi Kuwamoto, Yuki Murai, Yukari Endo, Toshihiko Masago, Naoto Kuroda, Yasushi Horie
BACKGROUND: Renal carcinomas associated with Xp11.2 translocations/TFE3 gene fusions are rare subtypes of renal neoplasm that predominantly occur in younger individuals. There are very few reports describing the cytologic features of these tumors. CASE: A 27-year-old man presented with hematuria and was found to have a mass in the lower part of the right kidney. Cytology of catheterized urine obtained from the right renal pelvis showed clusters of cells with abundant clear or eosinophilic granular cytoplasm, large round nuclei and prominent nucleoli...
2014: Acta Cytologica
Zhiqiang Zhang, Jie Min, Dexin Yu, Haoqiang Shi, Dongdong Xie
The simultaneous occurrence of different histological types of adjacent neoplasms in the same organ is called a collision tumour, and rarely occurs in the kidney. A 63-year-old female presented to the urology department with a 1-month history of a painless hematuria. The computed tomography scans of the abdomen revealed 2 heterogeneous incidental right renal masses. The patient underwent radical nephrectomy including lymphadenectomy without adjuvant therapy. Histopathological examination showed a type 2 renal collision tumour of the papillary renal cell carcinoma with eosinophilic cytoplasm and pseudostratified nuclei on papillary cores, and chromophobe renal cell carcinoma characterized by large polygonal cells with transparent reticulated cytoplasm and prominent cell membranes, which exhibited sarcomatoid transformation in the local area...
July 2014: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
Sean R Williamson, Liang Cheng, John N Eble, Lawrence D True, Nilesh S Gupta, Mingsheng Wang, Shaobo Zhang, David J Grignon
Rare renal epithelial neoplasms have been recognized to have an angioleiomyoma or leiomyoma-like proliferation of stromal smooth muscle; however, the nature of these tumors and their relationships to other renal cell carcinomas are poorly understood. We analyzed 23 such tumors for their clinicopathological, immunohistochemical, and cytogenetic features using fluorescence in situ hybridization. Twelve showed a homogeneous combination of features and were reclassified as renal cell carcinoma with angioleiomyoma-like stroma...
February 2015: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Juan Guo, Maria S Tretiakova, Megan L Troxell, Adeboye O Osunkoya, Oluwole Fadare, Ankur R Sangoi, Steven S Shen, Antonio Lopez-Beltran, Rohit Mehra, Amer Heider, John P Higgins, Lara R Harik, Xavier Leroy, Anthony J Gill, Kiril Trpkov, Steven C Campbell, Christopher Przybycin, Cristina Magi-Galluzzi, Jesse K McKenney
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder with characteristic tumors involving multiple organ systems. Whereas renal angiomyolipoma (AML) is common in TSC, renal cell carcinoma (RCC) is rarely reported. Fifty-seven RCCs from 13 female and 5 male TSC patients were reviewed. Age at surgery ranged from 7 to 65 years (mean: 42 y). Nine patients (50%) had multiple synchronous and/or metachronous RCCs (range of 2 to 20 RCCs) and 5 had bilateral RCCs (28%). Seventeen patients (94%) had histologically confirmed concurrent renal AMLs, including 15 with multiple AMLs (88%) and 9 (50%) with AMLs with epithelial cysts...
November 2014: American Journal of Surgical Pathology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"