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pink renal neoplasms

Sara E Wobker, Minghao Zhong, Jonathan I Epstein
We report 13 cases of unique polypoid urothelial tumors with inverted growth pattern (PUTIP) occurring in the proximal ureter and renal pelvis. We describe their morphologic features and further characterize them in regard to TERT promoter mutation status and microsatellite instability. 13 cases were identified in our consult archives from 1994 to present. Patients ranged in age from 52 to 83 years old at the time of diagnosis (mean=68.4 years). Grossly, lesions were described variously as pink-tan to white exophytic and friable lesions that were polypoid or pedunculated, located in the renal pelvis or proximal ureter...
August 26, 2016: Human Pathology
Carolina Reyes, Yevgeniy Karamurzin, Norma Frizzell, Karuna Garg, Daisuke Nonaka, Ying-Bei Chen, Robert A Soslow
Rare, sporadic uterine leiomyomas arise in the setting of severe metabolic aberration due to a somatic fumarate hydratase mutation. Germline mutations account for the hereditary leiomyomatosis and renal cell carcinoma syndrome, which predisposes for cutaneous and uterine leiomyomas and aggressive renal cell carcinomas. Altered fumarate hydratase leads to fumarate accumulation in affected cells with formation of S-(2-succino)-cysteine, which can be detected with the polyclonal antibody. High levels of these modified cysteine residues are found characteristically in fumarate hydratase-deficient cells but not in normal tissues or tumors unassociated with hereditary leiomyomatosis and renal cell carcinoma syndrome...
July 2014: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Sedat Yilmaz, Ahmet Karakas, Muhammet Cinar, Omer Coskun, Ismail Simsek, Hakan Erdem, Can Polat Eyigun, Salih Pay
Adult onset Still's disease (AOSD) is a systemic inflammatory disease with unknown etiology and characterized by evanescent salmon pink rash, sore throat, liver dysfunction, lymphadenopathy, hepatosplenomegaly, arthritis, and leukocytosis. It is a diagnosis of exclusion; however, there are case reports in the literature about patients with malignancies and AOSD-like signs and symptoms. Here we report a patient with AOSD seems to be associated with sarcomatoid renal cell carcinoma. This phenomenon is not distinguishable from primary AOSD either in presentation or in treatment; except for the main purpose of the management should be targeted to the underlying malignancy...
2013: Bulletin of the Hospital for Joint Diseases
Manish Bansal, Kajal Manchanda, Shyam Sunder Pandey
Keratoacanthoma is a well-known, fast-growing, benign squamous epithelial neoplasm that usually presents as a solitary, dome-shaped, pink or flesh-colored nodule developing a central keratin-filled crater. Few authors consider it to be a benign cutaneous tumor whereas others suggest that it should be regarded as a low-grade variant of cutaneous squamous cell carcinoma (SCC). A 21-year-old female presented with a firm, nontender, well-defined plaque with irregular margins measuring about 8 × 4 cm over the dorsal aspect of the right foot along with an exuberant growth from the plaque measuring 4 × 5cm...
June 2012: International Journal of Lower Extremity Wounds
Ryan P Johnson, Kevin Krauland, Nicole M Owens, Stephen Peckham
A 40-year-old woman presented to the Brooke Army Medical Center Emergency Department complaining of 2 episodes of gross hematuria. Computed tomography and intravenous pyelogram revealed a right renal mass. A radical nephrectomy was performed with complete excision of the mass with negative margins on histological examination. The patient was diagnosed with renal medullary carcinoma, Fuhrman grade 4, based upon histological examination. A positron emission tomography scan revealed no other evidence of the disease...
February 2011: American Journal of Dermatopathology
Derek Power, Diane Reidy Lagunes
A 20-year-old African American male presented with a history of left flank pain and passing of light pink urine. Medical history included sickle cell trait. Urine analysis was positive for protein and blood. Metabolic profile, autoantibody screen, and complement levels were normal. Hemoglobin electrophoresis revealed an 41.8% HbS diagnostic of sickle cell trait. Creatinine clearance was normal and proteinuria was nonnephrotic. A noncontrast computed tomography (CT) scan showed left proximal hydronephrosis. Urology follow-up was arranged and the differential included renal papillary necrosis, or renal cyst rupture...
August 2009: Clinical Genitourinary Cancer
Min-Wee Chia, Yong-Kwang Tay, Suat-Hoon Tan
A 53-year-old Chinese man presented with a history of painful lesions on the chest of 20 years' duration. He experienced sharp pain especially on touching and after spicy food. The lesions were stable with no increase in size or number. He was otherwise well. There was no significant family history. Physical examination revealed multiple, grouped, pink papules on the left chest, extending to the right back in a segmental distribution, each measuring 2-5 mm (Figs 1 and 2). They appeared pearly and keloid-like, and had a firm consistency...
November 2008: International Journal of Dermatology
David Parada, All Godoy, Francisco Liuzzi, Karla B Pelia, Aramis Romero, Arelí M Parada
OBJECTIVE: Ewing's sarcoma/Primitive neuroectodermal tumor (ES/PNET) is an extraordinarily rare primary tumor in the kidney. We re-port herein the clinical, histological, and immunohisto-chemical features of a primary renal ES/PNET. METHODS: A 19-year old male referred a two weeks history of constant, colic, left flank pain, and fever. A left radical nephrectomy was performed. Gross pathologic examination showed pink-tan, lobulated solid tumor, localized at the superior pole...
April 2007: Archivos Españoles de Urología
Hakan Demirci, Christine C Nelson, Carol L Shields, Ralph C Eagle, Jerry A Shields
We report the rare but serious association between sebaceous carcinoma of eyelid and Muir-Torre syndrome in two cases, a 79-year-old woman and 54-year-old man. The presenting sign was a yellow-pink nodule with telangiectatic vessels on the left lower eyelid in one patient and a yellowish-red, pedunculated lesion with intrinsic vascularization on the right superior tarsal conjunctiva in the other. A history of multiple primary colon cancers was present in both patients, associated transitional cell carcinoma of bladder and renal cancer in one patient and prostate cancer in the other...
January 2007: Ophthalmic Plastic and Reconstructive Surgery
Archana Deshpande, Maitreyee Munshi
Renal oncocytomas are rare renal parenchymal neoplasms which have a good prognosis. An accurate pre-operative diagnosis by guided fine needle aspiration cytology helps to plan a more conservative surgery. Cytologic findings in a case of renal oncocytoma are presented. Smears showed polygonal or rounded cells in groups and acinar pattern having a well-defined, granular, eosinophilic cytoplasm, and round regular nuclei displaying very little pleomorphism. Intra and extracellular hyaline material staining pink with May Grunwald Giemsa stain were seen...
April 2005: Indian Journal of Pathology & Microbiology
(no author information available yet)
1-Amino-2,4-dibromoanthraquinone is an anthraquinone-derived vat dye, a member of a class of insoluble dyes that are impregnated into textile fibers. Five anthraquinone-derived dyes with representative and diverse structures, as well as the parent chemical, anthraquinone, were selected for NTP Toxicology and Carcinogenesis evaluation. Similar to the benzidine dye initiative, the rationale for selecting these vat dyes was to generate sufficient toxicologic data to permit more reliable predictions of carcinogenicity to be made on other chemicals in this class, thereby eliminating or reducing the need to study every anthraquinone dye...
August 1996: National Toxicology Program Technical Report Series
P Reichardt, D Pink, J Tilgner, A Kretzschmar, P C Thuss-Patience, B Dörken
OBJECTIVES: Aim of this study was to evaluate the feasibility and toxicity of oral trofosfamide given as maintenance therapy to adult patients with bone and soft tissue sarcomas following first or later line induction chemotherapy, and to determine the clinical efficacy in terms of impact on progression-free and overall survival. PATIENTS AND METHODS: 49 patients with locally advanced or metastatic high-grade soft tissue and bone sarcomas were identified retrospectively according to the inclusion criteria of the analysis...
December 2002: Onkologie
Sogol Saghari, Heather Woolery-Lloyd, Keyvan Nouri
A 29-year-old white woman with a history of Netherton's syndrome presented with two squamous cell carcinomas on the right dorsal hand and the left upper arm. She reported a 2-year history of these lesions, which were originally treated as warts. She denied excessive sun exposure, immunosuppressive therapy, or a previous history of skin cancer. Her past medical history included acute renal failure, multiple urinary tract infections, meningitis, and recurrent otitis media as a child. In addition, she had an ovarian abscess at 4 years of age with resulting salpingo-oophorectomy...
July 2002: International Journal of Dermatology
N Kumar, S Jain
A case of adult mesoblastic nephroma (MN) was erroneously interpreted as a benign mesenchymal tumor on fine-needle aspiration (FNA) cytology. MN is a rare tumor in infants and is extremely uncommon in adults. A 50-yr-old female presented with a renal lump with the clinicoradiological possibility of renal-cell carcinoma. Giemsa-stained smears were highly cellular and showed cohesive interlacing fragments of spindle cells embedded in abundant pink fibrillary stromal matrix. Epithelial component was seen in the form of tubules...
August 2000: Diagnostic Cytopathology
M C Walther, T H Shawker, S K Libutti, I Lubensky, P L Choyke, D Venzon, W M Linehan
PURPOSE: Small renal tumors are frequently detected during the screening of patients with a hereditary type of renal cancer. The development of nonsurgical treatment modalities would greatly improve quality of life in these patients. We present our experience with radio frequency interstitial tissue ablation, a heating device approved by the Food and Drug Administration for treating soft tissue tumors. MATERIALS AND METHODS: Patients underwent radio frequency interstitial tissue ablation of small renal tumors just before surgical excision...
May 2000: Journal of Urology
H Birgisson, G V Einarsson, M Steinarsdóttir, J G Jónasson
A 59-year old woman was diagnosed with a tumour in her right kidney. A nephrectomy was performed, and a 45 mm diameter tan-pink coloured tumour was found. Microscopy revealed small, dark cells in organized arrays of small round acini and tubules with glomeruloid infoldings. A diagnosis of metanephric adenoma was made. The tumour cells proved diploid on flow cytometry and immunohistochemical staining was positive for CAM 5.2 and AE-3. FISH analysis of three chromosomes did not reveal any abnormal karyotype. It is important to differentiate metanephric adenoma from renal cell carcinoma and adult Wilm's tumour, since it has a benign course...
October 1999: Scandinavian Journal of Urology and Nephrology
M Tsuji, Y Murakami, H Kanayama, T Sano, S Kagawa
BACKGROUND: A unique case of metanephric adenoma of the left kidney is reported in a 61-year-old woman presenting with an incidental renal mass on ultrasonography. METHODS/RESULTS: On radiographic examination, the presence of hypovascular renal cell carcinoma was suspected and left radical nephrectomy was performed. The resected tumor, measuring 4.9 x 4.7 x 4.5 cm, was well-circumscribed and solid and its cut surface was tan-pink with foci of focal hemorrhage and cystic change...
April 1999: International Journal of Urology: Official Journal of the Japanese Urological Association
H Oyama, I Fukui, Y Maeda, K Yoshimura, H Maeda, T Izutani, T Yamauchi, T Kawai, Y Ishikawa, N Yamamoto
A 34-year-old house wife presented with a right renal mass detected by work-up for epigastralgia. The mass located in the right renal sinus was round and approximately 3 cm in diameter. Although the tumor was well enhanced with contrast medium on CT scan, it was hypovascular on the early arterial phase of renal angiography. Translumbar radical nephrectomy was performed on suspicion of the right renal cell carcinoma. The tumor was solid and hard and, the cut surface of the tumor was homogenously colored pale pink...
January 1998: Nihon Hinyōkika Gakkai Zasshi. the Japanese Journal of Urology
R R Buggage, N Soudi, J L Olson, A E Busseniers
Epithelioid hemangioendothelioma (EHE) of the lung is a low-grade malignant tumor of vascular origin initially described under the name intravascular bronchioloalveolar tumor (IVBAT). We present a case of a 44-yr-old Caucasian female with severe radiating back pain, shortness of breath, recurrent malignant pleural effusions, and a negative malignancy workup. Cytopathologic examination of the four pleural fluid specimens revealed large undifferentiated plasmacytoid malignant cells with abundant pink and finely granular cytoplasm, round nuclei, and prominent nucleoli...
July 1995: Diagnostic Cytopathology
M J Merino, V A Livolsi
Fourteen cases of renal oncocytomas are presented. By definition these lesions are composed entirely of pink eosinophilic cells with abundant granular cytoplasm. No evidence of mitotic activity or necrosis was seen in any of the cases, although focal areas of nuclear pleomorphism were identified in two cases. Clinically the patients have remained asymptomatic and without evidence of metastatic or recurrent disease in a follow-up that ranges from 1-14 years. The clinical behavior of these tumors favors the benign nature of the lesion regardless of the tumor size...
November 1, 1982: Cancer
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