Laurie De Castro, Annabelle Manoury, Olivier Claude, Bastien Simoneau, Virginie Monceau, David Suhard, Christelle Elie, Victor Magneron, Laurence Roy, Céline Bouvier-Capely, Chrystelle Ibanez, Estelle Davesne, Yann Guéguen
During nuclear fuel processing, workers can potentially be exposed to repeated inhalations of uranium compounds. Uranium nephrotoxicity is well documented after acute uranium intake, but it is controversial after long-term or protracted exposure. This study aims to analyze the nephrotoxicity threshold after repeated uranium exposure through upper airways and to investigate the resulting uranium biokinetics in comparison to reference models. Mice (C57BL/6J) were exposed to uranyl nitrate (0.03-3 mg/kg/day) via intranasal instillation four times a week for two weeks...
March 13, 2023: Scientific Reports