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https://www.readbyqxmd.com/read/29135325/facile-development-of-nanocomplex-in-nanoparticles-for-enhanced-loading-and-selective-delivery-of-doxorubicin-to-brain
#1
Amr Hefnawy, Islam A Khalil, Ibrahim M El-Sherbiny
AIM: Facile development of polysaccharides-based carrier system for efficient delivery of doxorubicin (DOX) to the brain. METHODS: DOX was nanocomplexed with alginate (Alg) followed by incorporation into chitosan (Cs) nanomatrices. The resulting carriers were optimized to have a net positive charge improving their delivery across the blood-brain barrier. The optimum DOX-loaded nanosystem was targeted to brain tissue via loading into various nasal dosage forms. RESULTS: The pH-dependent ionization of both DOX and Alg was found to have a significant effect on DOX entrapment efficiency which was improved from 4% at slightly acidic media to 85% using different pHs...
November 14, 2017: Nanomedicine
https://www.readbyqxmd.com/read/29134552/intranasal-delivery-of-%C3%AE-asarone-to-the-brain-with-lactoferrin-modified-mpeg-pla-nanoparticles-prepared-by-premix-membrane-emulsification
#2
Linmei Pan, Jing Zhou, Feng Ju, Huaxu Zhu
Alpha-asarone is a bioactive component of Acorus tatarincuii Schott with low bioavailability, which is often used for treatments of various brain diseases in clinical setting. This study was to formulate biodegradable methoxy polyethylene glycol-polylactic acid (mPEG-PLA) nanoparticles (NPs) surface-modified by lactoferrin (Lf), for delivering α-asarone into the brain following intranasal administration. Alpha-asarone NPs were prepared by premix membrane emulsification. The relative parameters were optimized by a Box-Behnken experimental design...
November 13, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29132545/nanoformulation-a-useful-therapeutic-strategy-for-improving-neuroprotection-and-the-neurorestorative-potential-in-experimental-models-of-parkinson-s-disease
#3
Jose V Lafuente, Catalina Requejo, Alejandro Carrasco, Harkaitz Bengoetxea
Parkinson's disease (PD) is the second most frequent neurodegenerative disorder, but current therapies are only symptomatic. Experimental models are necessary to go deeper in the comprehension of pathophysiological mechanism and to assess new therapeutic strategies. The unilateral 6-hydroxydopamine (6-OHDA) lesion either in medial forebrain bundle (MFB) or into the striatum in rats affords to study various stages of PD depending on the evolution time lapsed. A promising alternative to address the neurodegenerative process is the use of neurotrophic factors; but its clinical use has been limited due to its short half-life and rapid degradation after in vivo administration, along with difficulties for crossing the blood-brain barrier (BBB)...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/29130758/proniosomes-derived-niosomes-recent-advancements-in-drug-delivery-and-targeting
#4
Maryam Khatoon, Kifayat Ullah Shah, Fakhar Ud Din, Shefaat Ullah Shah, Asim Ur Rehman, Naz Dilawar, Ahmad Nawaz Khan
Vesicular drug delivery systems have gained wide attention in the field of nanotechnology. Among them proniosomes become the superior over other vesicular carriers. Proniosomes are dry formulations of water soluble nonionic surfactant coated carrier system which immediately forms niosomes upon hydration. They have the capability to overcome the instability problems associated with niosomes and liposomes and have the potential to improve solubility, bioavailability, and absorption of various drugs. Furthermore, they offer versatile drug delivery concept for enormous number of hydrophilic and hydrophobic drugs...
2017: Drug Delivery
https://www.readbyqxmd.com/read/29126941/glycol-chitosan-functionalized-asenapine-nanostructured-lipid-carriers-for-targeted-brain-delivery-pharmacokinetic-and-teratogenic-assessment
#5
Sanjay Kumar Singh, Mahendra Kumar Hidau, Shrikant Gautam, Kiran Gupta, Krishna Pal Singh, Shio Kumar Singh, Sanjay Singh
Blood brain barrier (BBB) is a complex, tight barrier between endothelial cells of cerebral blood vessels. It acts as a physical barrier and provides access to only those moieties which are necessary for proper brain functioning. However, this selective prudence also acts as a hindrance in therapeutic targeting of brain necessitating pharmaceutical intervention. Intranasal drug delivery is one such approach which we have exploited here for targeted brain delivery of asenapine via glycol chitosan coated nanostructured lipid carrier (GC-ANLC)...
November 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29115050/localization-of-the-t-cell-response-to-rsv-infection-is-altered-in-infant-mice
#6
Katherine M Eichinger, Jessica L Kosanovich, Kerry M Empey
OBJECTIVES: Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections worldwide, causing disproportionate morbidity and mortality in infants and children. Infants with stronger Th1 responses have less severe disease, yet little is known about the infant T-cell response within the air space. Thus, we tested the hypothesis that RSV infected infant mice would have quantitative and qualitative deficiencies in CD4(+) and CD8(+) T-cell populations isolated from the bronchoalveolar lavage when compared to adults and that local delivery of IFN-γ would increase airway CD4(+) Tbet(+) and CD8(+) Tbet(+) T-cell responses...
November 8, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29104777/studying-the-specific-activity-of-the-amide-form-of-hldf-6-peptide-using-the-transgenic-model-of-alzheimer-s-disease
#7
A P Bogachouk, Z I Storozheva, G B Telegin, A S Chernov, A T Proshin, V V Sherstnev, Yu A Zolotarev, V M Lipkin
The neuroprotective and nootropic activities of the amide form (AF) of the HLDF-6 peptide (TGENHR-NH2) were studied in transgenic mice of the B6C3-Tg(APPswe,PSEN1de9)85Dbo (Tg+) line (the animal model of familial Alzheimer's disease (AD)). The study was performed in 4 mouse groups: group 1 (study group): Tg+ mice intranasally injected with the peptide at a dose of 250 μg/kg; group 2 (active control): Tg+ mice intranasally injected with normal saline; group 3 (control 1): Tg- mice; and group 4 (control 2): C57Bl/6 mice...
July 2017: Acta Naturae
https://www.readbyqxmd.com/read/29079533/intranasal-administration-of-neuromedin-u-derivatives-containing-cell-penetrating-peptides-and-a-penetration-accelerating-sequence-induced-memory-improvements-in-mice
#8
Sachie Sasaki-Hamada, Taichi Funane, Yusuke Nakao, Rie Sasaki, Mio Nagai, Yudai Ueta, Kazumi Yoshizawa, Michiko Horiguchi, Chikamasa Yamashita, Jun-Ichiro Oka
Neuromedin U (NMU) is a neuropeptide that is expressed and secreted in the brain and gut. We previously demonstrated that the intracerebroventricular (i.c.v.) administration of NMU inhibited inflammation-mediated memory impairment in mice. In order to utilize NMU as a clinical treatment tool for inflammation-mediated amnesia, we herein focused on non-invasive intranasal delivery because the i.c.v. administration route is invasive and impractical. In the present study, we prepared two NMU derivatives containing cell-penetrating peptides (CPPs), octaarginine (R8), and each penetration-accelerating sequence, namely FFLIPKG (PASR8-NMU) and FFFFG (F4R8-NMU), for intranasal (i...
October 24, 2017: Peptides
https://www.readbyqxmd.com/read/29076066/recombinant-baculovirus-based-vaccine-expressing-m2-protein-induces-protective-cd8-t-cell-immunity-against-respiratory-syncytial-virus-infection
#9
Jeong-Yoon Lee, Jun Chang
Respiratory syncytial virus (RSV) is an important cause of acute lower respiratory tract disease in infants, young children, immunocompromised individuals, and the elderly. However, despite ongoing efforts to develop an RSV vaccine, there is still no authorized RSV vaccine for humans. Baculovirus has attracted attention as a vaccine vector because of its ability to induce a high level of humoral and cellular immunity, low cytotoxicity against various antigens, and biological safety for humans. In this study, we constructed a recombinant baculovirus- based vaccine expressing the M2 protein of RSV under the control of cytomegalovirus promoter (Bac_RSVM2) to induce CD8(+) T-cell responses which play an important role in viral clearance, and investigated its protective efficacy against RSV infection...
November 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/29066940/intranasal-naloxone-and-related-strategies-for-opioid-overdose-intervention-by-nonmedical-personnel-a-review
#10
REVIEW
Christa R Lewis, Hoa T Vo, Marc Fishman
Deaths due to prescription and illicit opioid overdose have been rising at an alarming rate, particularly in the USA. Although naloxone injection is a safe and effective treatment for opioid overdose, it is frequently unavailable in a timely manner due to legal and practical restrictions on its use by laypeople. As a result, an effort spanning decades has resulted in the development of strategies to make naloxone available for layperson or "take-home" use. This has included the development of naloxone formulations that are easier to administer for nonmedical users, such as intranasal and autoinjector intramuscular delivery systems, efforts to distribute naloxone to potentially high-impact categories of nonmedical users, as well as efforts to reduce regulatory barriers to more widespread distribution and use...
2017: Substance Abuse and Rehabilitation
https://www.readbyqxmd.com/read/29061523/behavioral-impairments-following-repeated-intranasal-glyphosate-based-herbicide-administration-in-mice
#11
Carlos Javier Baier, Cristina Eugenia Gallegos, Rita Raisman-Vozari, Alejandra Minetti
Inhalation or intranasal (IN) administration of neurotoxicants could constitute a route of toxin delivery to the brain. Pesticides have been proposed as the main environmental factor associated with the etiology of neurodegenerative disorders. In Argentina, the area used for glyphosate (Gly)-resistant crops are sprayed annually with ~200 million liters of Gly-based herbicides (Gly-BHs). Gly residues are often found in the environment, and considering the frequency and amount of its applications, it is probable that the inhalation of Gly-BHs occurs...
October 20, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/29061510/in-vivo-comparisons-of-silver-nanoparticle-and-silver-ion-transport-after-intranasal-delivery-in-mice
#12
Jonathan L Falconer, David W Grainger
Silver nanoparticles (AgNPs) are widely available as consumer goods, and over-the-counter or nutraceutical products used for alleged therapeutic and antibacterial properties. Among these products, AgNP topical therapy is proposed for treating patients with upper airway bacterial rhinosinusitis. While silver ion release from AgNPs in biological systems is well known, limited investigations actually characterize this silver ion release and their subsequent biological effects distinct from delivered particulate metallic silver...
October 20, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29046894/fatty-acid-mimetic-micelles-for-dual-delivery-of-antigens-and-imidazoquinoline-adjuvants
#13
Sema Sevimli, Frances C Knight, Pavlo Gilchuk, Sebastian Joyce, John T Wilson
Vaccine design has undergone a shift towards the use of purified protein subunit vaccines, which offer increased safety and greater control over antigen specificity, but at the expense of immunogenicity. Here we report the development of a new polymer-based vaccine delivery platform engineered to enhance immunity through the co-delivery of protein antigens and the Toll-like receptor 7 (TLR7) agonist imiquimod (IMQ). Owing to the preferential solubility of IMQ in fatty acids, a series of block copolymer micelles with a fatty acid-mimetic core comprising lauryl methacrylate (LMA) and methacrylic acid (MAA), and a poly(ethylene glycol) methyl ether methacrylate (PEGMA) corona decorated with pyridyl disulfide ethyl methacrylate (PDSM) moieties for antigen conjugation were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization...
February 13, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29038066/in-vitro-and-preclinical-assessment-of-an-intranasal-spray-formulation-of-parathyroid-hormone-pth-1-34-for-the-treatment-of-osteoporosis
#14
Allan J Williams, Faron Jordan, Gareth King, Andrew L Lewis, Lisbeth Illum, Tahir Masud, Alan C Perkins, Richard G Pearson
Osteoporosis treatment with PTH 1-34 injections significantly reduces the incidence of bone fracture. Potential further reductions in fracture rate should be observed through nasal spray delivery to address the poor compliance associated with patient dislike of repeated PTH 1-34 subcutaneous injections. In vitro human osteoblast-like Saos-2 cell intracellular cAMP levels were used to define PTH 1-34 nasal spray formulation bioactivity. The chemically synthesised PTH 1-34 had an EC50 of 0.76nM. Absorption enhancers polyethylene glycol (15)-hydroxystearate (Solutol(®) HS15), poloxamer 407, chitosan or sodium hyaluronate did not diminish the bioactivity of PTH 1-34 within an in vitro cell culture model (p >0...
October 14, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29035509/positron-emission-tomography-assessment-of-the-intranasal-delivery-route-for-orexin-a
#15
Genevieve C Van de Bittner, Kyle C Van de Bittner, Hsiao-Ying Wey, Wayne Rowe, Ram Dharanipragada, Xiaoyou Ying, William Hurst, Andrew Giovanni, Kim Alving, Anurag Gupta, John Hoekman, Jacob M Hooker
Intranasal drug delivery is a noninvasive drug delivery route that can enhance systemic delivery of therapeutics with poor oral bioavailability by exploiting the rich microvasculature within the nasal cavity. The intranasal delivery route has also been targeted as a method for improved brain uptake of neurotherapeutics, with a goal of harnessing putative, direct nose-to-brain pathways. Studies in rodents, nonhuman primates, and humans have pointed to the efficacy of intranasally delivered neurotherapeutics, while radiolabeling studies have analyzed brain uptake following intranasal administration...
November 7, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29034965/role-of-serum-albumin-as-a-nanoparticulate-carrier-for-nose-to-brain-delivery-of-r-flurbiprofen-implications-for-the-treatment-of-alzheimer-s-disease
#16
Ling Rong Wong, Paul C Ho
OBJECTIVES: R-flurbiprofen (R-FP) was found to offer neuroprotective effects by inhibiting mitochondrial calcium overload induced by β-amyloid peptide toxicity in Alzheimer's disease (AD). However, poor brain penetration after oral administration posed a challenge to its further development for AD treatment. In this study, we investigated the potential of serum albumin as nanoparticulate carriers for nose-to-brain delivery of R-FP to improve its brain accumulation. METHODS: Mice were subjected to three treatment groups: (1) intranasal R-FP solution, (2) oral R-FP solution and (3) intranasal R-FP albumin nanoparticles...
October 16, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29034836/nanomedicine-for-intranasal-delivery-to-improve-brain-uptake
#17
Amit A Patel, Ravish J Patel, Shachi R Patel
Intranasal drug delivery system provide distinct advantage over conventional drug delivery system for a drug that is pharmacokenetically or biologically unstable. Major concern for treatment of central nervous system diseases are law concentration of therapeutically active molecule within brain as blood brain barrier is creating obstacle, where intranasal drug delivery provides direct transport of therapeutically active moiety into brain via olfactory or trigeminal pathway. Nasal mucosa provides distinct advantage like improved bioavailability, law dose and quick onset of action and high patient compliance, major disadvantage is residence time of drug and irreversible entrapment of drug...
October 13, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29034453/avp-825-sumatriptan-nasal-powder-reduces-nausea-compared-to-sumatriptan-tablets-results-of-the-compass-randomized-clinical-trial
#18
Richard B Lipton, James S McGinley, Kenneth J Shulman, Stephen D Silberstein, R J Wirth, Dawn C Buse
BACKGROUND: Migraine-related nausea is associated with significant disability, increased burden of disease, and personal distress. Nausea can lead to delays or avoidance of initiating oral migraine treatment, sometimes resulting in treatment failures and poor outcomes. Nausea is often a symptom of migraine, but nausea may also be a consequence of treatment (ie, treatment emergent nausea [TEN]). Relieving nausea and minimizing TEN are important goals in acute migraine therapy. METHODS: We analyzed data from the COMPASS study, a randomized, double blind, double-dummy, comparative efficacy study that contrasted two active treatments, AVP-825 (breath-powered intranasal delivery of powdered sumatriptan 22 mg) and oral sumatriptan tablets (100 mg)...
October 16, 2017: Headache
https://www.readbyqxmd.com/read/29030308/engineering-intranasal-mrna-vaccines-to-enhance-lymph-node-trafficking-and-immune-responses
#19
Man Li, You Li, Ke Peng, Ying Wang, Tao Gong, Zhirong Zhang, Qin He, Xun Sun
Intranasal mRNA vaccination provides immediate immune protection against pandemic diseases. Recent studies have shown that diverse forms of polyethyleneimine (PEI) have potent mucosal adjuvant activity, which could significantly facilitate the delivery of intranasal mRNA vaccines. Nevertheless, optimizing the chemical structure of PEI to maximize its adjuvanticity and decrease its toxicity remains a challenge. Here we show that the chemical structure of PEI strongly influences how well nanocomplexes of PEI and mRNA migrate to the lymph nodes and elicit immune responses...
December 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29029568/quaternized-chitosan-nanoparticles-loaded-with-the-combined-attenuated-live-vaccine-against-newcastle-disease-and-infectious-bronchitis-elicit-immune-response-in-chicken-after-intranasal-administration
#20
Kai Zhao, Shanshan Li, Wei Li, Lu Yu, Xutong Duan, Jinyu Han, Xiaohua Wang, Zheng Jin
Newcastle disease (ND) and infectious bronchitis (IB) are important diseases, which cause respiratory diseases in chickens, resulting in severely economic losses in the poultry industry. In this study, N-2-hydroxypropyl trimethyl ammonium chloride chitosan (N-2-HACC) and N,O-carboxymethyl chitosan (CMC) were synthesized as adjuvant and delivery carrier for vaccine antigens. N-2-HACC-CMC/NDV/IBV nanoparticles (NPs) (NDV/La Sota and IBV/H120 encapsulated in N-2-HACC-CMC NPs) and N-2-HACC-CMC/NDV-IBV NPs (the mixing of N-2-HACC-CMC/NDV NPs and N-2-HACC-CMC/IBV NPs in a ratio of 1:1) were prepared by the polyelectrolyte composite method, respectively...
November 2017: Drug Delivery
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