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https://www.readbyqxmd.com/read/28102083/development-and-characterization-of-morin-hydrate-loaded-microemulsion-for-the-management-of-alzheimer-s-disease
#1
Dheeraj Sharma, Manpreet Singh, Punnet Kumar, Vir Vikram, Neeraj Mishra
The aim of this study is to prepare and characterize intranasal delivery of morin hydrate loaded microemulsion for the management of Alzheimer's diseases. After intranasal delivery, brain and blood drug concentrations were found to be higher for optimized morin hydrate loaded microemulsion as compared to plain morin hydrate. Significant (P < 0.05) reduction in assessed pharmacodynamic parameters was observed after intranasal administration of morin hydrate loaded microemulsion as compared to sham control group...
January 19, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28101766/crossing-the-blood-brain-barrier-recent-advances-in-drug-delivery-to-the-brain
#2
Mayur M Patel, Bhoomika M Patel
CNS disorders are on the rise despite advancements in our understanding of their pathophysiological mechanisms. A major hurdle to the treatment of these disorders is the blood-brain barrier (BBB), which serves as an arduous janitor to protect the brain. Many drugs are being discovered for CNS disorders, which, however fail to enter the market because of their inability to cross the BBB. This is a pronounced challenge for the pharmaceutical fraternity. Hence, in addition to the discovery of novel entities and drug candidates, scientists are also developing new formulations of existing drugs for brain targeting...
January 18, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28094952/effect-of-an-enhanced-nose-to-brain-delivery-of-insulin-on-mild-and-progressive-memory-loss-in-the-senescence-accelerated-mouse
#3
Noriyasu Kamei, Misa Tanaka, Hayoung Choi, Nobuyuki Okada, Takamasa Ikeda, Rei Itokazu, Mariko Takeda-Morishita
Insulin is now considered to be a new drug candidate for treating dementias, such as Alzheimer's disease, whose pathologies are linked to insulin resistance in the brain. Our recent work has clarified that a noncovalent strategy involving cell-penetrating peptides (CPPs) can increase the direct transport of insulin from the nasal cavity into the brain parenchyma. The present study aimed to determine whether the brain insulin level increased by intranasal coadministration of insulin with the CPP penetratin has potential for treating dementia...
January 17, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28063773/the-implementation-of-a-naloxone-rescue-program-in-university-students
#4
Shannon G Panther, Brenda S Bray, John R White
OBJECTIVE: Responding to the nationwide opioid overdose epidemic, Washington State University initiated a naloxone safety net project intending to increase awareness of opioid overdose, increase the availability of naloxone, and examine university students' perceptions regarding the usefulness of a novel, large-group audience-training model. SETTING: A Washington State University campus. PRACTICE DESCRIPTION: In September 2014, university students were recruited to attended a large-group audience training event which included opioid overdose prevention, recognition, and first response...
January 4, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28057521/biodegradable-nanoparticle-delivery-of-inactivated-swine-influenza-virus-vaccine-provides-heterologous-cell-mediated-immune-response-in-pigs
#5
Santosh Dhakal, Jagadish Hiremath, Kathryn Bondra, Yashavanth S Lakshmanappa, Duan-Liang Shyu, Kang Ouyang, Kyung-Il Kang, Basavaraj Binjawadagi, Jonathan Goodman, Kairat Tabynov, Steven Krakowka, Balaji Narasimhan, Chang-Won Lee, Gourapura J Renukaradhya
Swine influenza virus (SwIV) is one of the important zoonotic pathogens. Current flu vaccines have failed to provide cross-protection against evolving viruses in the field. Poly lactic-co-glycolic acid (PLGA) is a biodegradable FDA approved polymer and widely used in drug and vaccine delivery. In this study, inactivated SwIV H1N2 antigens (KAg) encapsulated in PLGA nanoparticles (PLGA-KAg) were prepared, which were spherical in shape with 200 to 300nm diameter, and induced maturation of antigen presenting cells in vitro...
January 2, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28056358/administrations-of-human-adult-ischemia-tolerant-mesenchymal-stem-cells-and-factors-reduce-amyloid-beta-pathology-in-a-mouse-model-of-alzheimer-s-disease
#6
Taoufiq Harach, Fabien Jammes, Charles Muller, Nicolas Duthilleul, Victoria Cheatham, Valentin Zufferey, David Cheatham, Yelizaveta A Lukasheva, Theo Lasser, Tristan Bolmont
The impact of human adult ischemia-tolerant mesenchymal stem cells (hMSCs) and factors (stem cell factors) on cerebral amyloid beta (Aβ) pathology was investigated in a mouse model of Alzheimer's disease (AD). To this end, hMSCs were administered intravenously to APPPS1 transgenic mice that normally develop cerebral Aβ. Quantitative reverse transcriptase polymerase chain reaction biodistribution revealed that intravenously delivered hMSCs were readily detected in APPPS1 brains 1 hour following administration, and dropped to negligible levels after 1 week...
November 24, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/28056224/recombinant-fowlpox-virus-vector-based-vaccines-expression-kinetics-dissemination-and-safety-profile-following-intranasal-delivery
#7
David G Townsend, Shubhanshi Trivedi, Ronald J Jackson, Charani Ranasinghe
We have previously established that mucosal uptake of recombinant fowlpox virus (rFPV) vaccines is far superior to other vector-based vaccines. Specifically, intranasal (i.n.) priming with rFPV vaccines can recruit unique antigen presenting cells (APC), which induce excellent mucosal and systemic HIV-specific CD8+ T cell immunity. In this study, we have for the first time investigated the in-vivo dissemination, safety and expression kinetics of rFPV post i.n. delivery using recombinant viruses expressing green fluorescent protein (GFP) or mCherry...
January 5, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28052034/antidepressant-effect-of-recombinant-nt4-nap-aav-on-social-isolated-mice-through-intranasal-route
#8
Fei Liu, You-Ping Liu, Gang Lei, Peng Liu, Zheng Chu, Cheng-Ge Gao, Yong-Hui Dang
The purpose of the present study was to observe the depression-like behavior induced by social isolation; detect the antidepressant effect of a recombinant adeno-associated virus (AAV) expressing NAP on social isolation mice by intranasal delivery. After construction of NT4-NAP/AAV, expression of NAP was confirmed in vitro. 3-week-old C57/BL mice were bred individually in cages as social isolation-rearing. Six weeks later, the first subset of mice underwent behavioral tests and western blot; the second was for enzyme-linked immunosorbent assay...
December 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/28041780/unique-cellular-and-humoral-immunogenicity-profiles-generated-by-aerosol-intranasal-or-parenteral-vaccination-in-rhesus-macaques
#9
Diane L Bolton, Kaimei Song, Georgia D Tomaras, Srinivas Rao, Mario Roederer
Respiratory mucosa immunization is capable of eliciting both local and distal mucosal immune responses; it is a potentially powerful yet largely unused modality for vaccination against respiratory diseases. Targeting the lower versus upper airways by aerosol delivery alters the immunogenicity profile of a vaccine, although the full extent of this impact is not well characterized. We set out to define the cellular and humoral response profiles elicited by immunization via intranasal, small aerosol droplets, and large aerosol droplets...
January 23, 2017: Vaccine
https://www.readbyqxmd.com/read/28031222/the-chemokine-cxcl12-mediates-the-anti-amyloidogenic-action-of-painless-human-nerve-growth-factor
#10
Simona Capsoni, Francesca Malerba, Nicola Maria Carucci, Caterina Rizzi, Chiara Criscuolo, Nicola Origlia, Mariantonietta Calvello, Alessandro Viegi, Giovanni Meli, Antonino Cattaneo
Nerve growth factor is a therapeutic candidate for Alzheimer's disease. Due to its pain-inducing activity, in current clinical trials nerve growth factor is delivered locally into the brain by neurosurgery, but data on the efficacy of local nerve growth factor delivery in decreasing amyloid-β deposition are not available. To reduce the nerve growth factor pain-inducing side effects, thus avoiding the need for local brain injection, we developed human painless nerve growth factor (hNGFp), inspired by the human genetic disease hereditary sensory and autonomic neuropathy type V...
January 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28028827/novel-application-for-electrochemotherapy-immersion-of-nasal-cavity-in-dog
#11
Daniela O H Suzuki, José A Berkenbrock, Krishna D de Oliveira, Jennifer O Freytag, Marcelo M M Rangel
Electrochemotherapy is a new modality of local cancer treatment that increases the delivery of chemotherapy drugs into tumor cells by applying intense electric fields. This novel electrochemotherapy application was applied as an adjuvant to surgery and eliminated intranasal tumors in dog. The treatment challenges are the surgery limitations due to anatomy and residual tumor in the bone cavity. Most of the tumoral mass on nasal cavity was surgically removed. The internal nasal cavity was immersed in liquid and bleomycin before applying electric field...
December 27, 2016: Artificial Organs
https://www.readbyqxmd.com/read/28025949/targeted-nanoparticles-for-the-treatment-of-alzheimer-s-disease
#12
Rafael Martín-Rapún, Laura De Matteis, Alfredo Ambrosone, Sonia García-Embid, Lucía Gutiérrez, Jesús M de la Fuente
BACKGROUND: Alzheimer's disease (AD) has a dramatic impact on society. The therapeutic targets are located in the central nervous system (CNS), which limits the efficacy of drugs systemically administered: the blood brain barrier (BBB) selectively allows the permeation of just a few kinds of molecules from the systemic circulation to the CNS. On the other hand, local administration routes to CNS are highly invasive. METHODS: In this article, we have reviewed therapeutic approaches against AD, which are based on nanoparticles targeted to the brain and to the pathological hallmarks of the disease...
December 26, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28009478/local-effects-on-airway-inflammation-and-systemic-uptake-of-5-nm-pegylated-and-citrated-gold-nanoparticles-in-asthmatic-mice
#13
Albert J Omlor, Duc D Le, Janine Schlicker, Matthias Hannig, Raphael Ewen, Sebastian Heck, Christian Herr, Annette Kraegeloh, Christina Hein, Ralf Kautenburger, Guido Kickelbick, Robert Bals, Juliane Nguyen, Q Thai Dinh
Nanotechnology is showing promise in many medical applications such as drug delivery and hyperthermia. Nanoparticles administered to the respiratory tract cause local reactions and cross the blood-air barrier, thereby providing a means for easy systemic administration but also a potential source of toxicity. Little is known about how these effects are influenced by preexisting airway diseases such as asthma. Here, BALB/c mice are treated according to the ovalbumin (OVA) asthma protocol to promote allergic airway inflammation...
December 23, 2016: Small
https://www.readbyqxmd.com/read/27997619/intranasal-chromium-induces-acute-brain-and-lung-injuries-in-rats-assessment-of-different-potential-hazardous-effects-of-environmental-and-occupational-exposure-to-chromium-and-introduction-of-a-novel-pharmacological-and-toxicological-animal-model
#14
Abeer Salama, Rehab Hegazy, Azza Hassan
Chromium (Cr) is used in many industries and it is widely distributed in the environment. Exposure to Cr dust has been reported among workers at these industries. Beside its hazardous effects on the lungs, brain injury could be induced, as the absorption of substances through the nasal membrane has been found to provide them a direct delivery to the brain. We investigated the distribution and the effects of Cr in both brain and lung following the intranasal instillation of potassium dichromate (inPDC) in rats...
2016: PloS One
https://www.readbyqxmd.com/read/27994458/intranasal-delivery-of-rotigotine-to-the-brain-with-lactoferrin-modified-peg-plga-nanoparticles-for-parkinson-s-disease-treatment
#15
Chenchen Bi, Aiping Wang, Yongchao Chu, Sha Liu, Hongjie Mu, Wanhui Liu, Zimei Wu, Kaoxiang Sun, Youxin Li
Sustainable and safe delivery of brain-targeted drugs is highly important for successful therapy in Parkinson's disease (PD). This study was designed to formulate biodegradable poly(ethylene glycol)-poly(lactic-co-glycolic acid) (PEG-PLGA) nanoparticles (NPs), which were surface-modified with lactoferrin (Lf), for efficient intranasal delivery of rotigotine to the brain for the treatment of PD. Rotigotine NPs were prepared by nanoprecipitation, and the effect of various independent process variables on the resulting properties of NPs was investigated by a Box-Behnken experimental design...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27979769/the-samp8-mouse-for-investigating-memory-and-the-role-of-insulin-in-the-brain
#16
Elizabeth M Rhea, William A Banks
SAMP8 mice exhibit changes that commonly occur with normal aging late in life, but do so at a much earlier age. These changes include impairments in learning and memory as early as 8months of age and so the SAMP8 is a useful model to investigate those age-related brain changes that may affect cognition. As brain insulin signaling and memory decline with aging, the SAMP8 model is useful for investigating these changes and interventions that might prevent the decline. This review will summarize the SAMP8 mouse model, highlight changes in brain insulin signaling and its role in memory, and discuss intranasal insulin delivery in investigating effects on insulin metabolism and memory in the SAMP8 mice...
December 12, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/27977306/nasal-and-olfactory-deposition-with-normal-and-bidirectional-intranasal-delivery-techniques-in-vitro-tests-and-numerical-simulations
#17
Jinxiang Xi, Zhaoxuan Wang, Danielle Nevorski, Thomas White, Yue Zhou
BACKGROUND: Intranasal delivery protocols that can effectively deposit drugs to the olfactory region are severely lacking. Furthermore, it is still challenging to quantify nasal deposition on a regional or local basis, which is crucial in assessing the performance of targeted olfactory drug delivery. OBJECTIVES: To visually and quantitatively compare drug depositions in the nose and olfactory region with normal and bidirectional breathing patterns with vibrating mesh and jet nebulizers...
December 15, 2016: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/27943132/new-non-intravenous-routes-for-benzodiazepines-in-epilepsy-a-clinician-perspective
#18
Marco Mula
Benzodiazepines represent the first-line treatment for the acute management of epileptic seizures and status epilepticus. The emergency use of benzodiazepines must be timely, and because most seizures occur outside of the hospital environment, there is a significant need for delivery methods that are easy for nonclinical caregivers to use and administer quickly and safely. In addition, the ideal route of administration should be reliable in terms of absorption. Rectal diazepam is the only licensed formulation in the USA, whereas rectal diazepam and buccal midazolam are currently licensed in the EU...
December 9, 2016: CNS Drugs
https://www.readbyqxmd.com/read/27927058/immunoadjuvant-potential-of-cross-linked-dextran-microspheres-mixed-with-chitosan-nanospheres-encapsulated-with-tetanus-toxoid
#19
Haniyeh Pirouzmand, Bahman Khameneh, Mohsen Tafaghodi
CONTEXT: Nasal mucosa is a desirable route for mucosal vaccine delivery. Mucosal co-administration of chitosan nanoparticles with absorption enhancers such as cross-linked dextran microspheres (CDM, Sephadex(®)) is a promising antigen delivery system. OBJECTIVE: In the current study, the chitosan nanospheres loaded with tetanus toxoid (CHT:TT NPs) was prepared and characterized. The immune responses against tetanus toxoid after nasal administration of CHT:TT NPs alone or mixed with CDM were also determined...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27913162/intranasal-delivery-of-antipsychotic-drugs
#20
REVIEW
Yogesh K Katare, Justin E Piazza, Jayant Bhandari, Ritesh P Daya, Kosalan Akilan, Madeline J Simpson, Todd Hoare, Ram K Mishra
Antipsychotic drugs are used to treat psychotic disorders that afflict millions globally and cause tremendous emotional, economic and healthcare burdens. However, the potential of intranasal delivery to improve brain-specific targeting remains unrealized. In this article, we review the mechanisms and methods used for brain targeting via the intranasal (IN) route as well as the potential advantages of improving this type of delivery. We extensively review experimental studies relevant to intranasal delivery of therapeutic agents for the treatment of psychosis and mental illnesses...
November 29, 2016: Schizophrenia Research
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