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https://www.readbyqxmd.com/read/28527238/a-widespread-family-of-serine-threonine-protein-phosphatases-shares-a-common-regulatory-switch-with-proteasomal-proteases
#1
Niels Bradshaw, Vladimir M Levdikov, Christina M Zimanyi, Rachelle Gaudet, Anthony J Wilkinson, Richard Losick
PP2C phosphatases control biological processes including stress responses, development, and cell division in all kingdoms of life. Diverse regulatory domains adapt PP2C phosphatases to specific functions, but how these domains control phosphatase activity was unknown. We present structures representing active and inactive states of the PP2C phosphatase SpoIIE from Bacillus subtilis. Based on structural analyses and genetic and biochemical experiments, we identify an α-helical switch that shifts a carbonyl oxygen into the active site to coordinate a metal cofactor...
May 20, 2017: ELife
https://www.readbyqxmd.com/read/28511909/discovery-and-structure-guided-fragment-linking-of-4-2-3-dichlorobenzoyl-1-methyl-pyrrole-2-carboxamide-as-a-pyruvate-kinase-m2-activator
#2
Yumi Matsui, Isao Yasumatsu, Takashi Asahi, Takahiro Kitamura, Kazuo Kanai, Osamu Ubukata, Hitoshi Hayasaka, Sachiko Takaishi, Hiroyuki Hanzawa, Shinichi Katakura
Tumor cells switch glucose metabolism to aerobic glycolysis by expressing the pyruvate kinase M2 isoform (PKM2) in a low active form, providing glycolytic intermediates as building blocks for biosynthetic processes, and thereby supporting cell proliferation. Activation of PKM2 should invert aerobic glycolysis to an oxidative metabolism and prevent cancer growth. Thus, PKM2 has gained attention as a promising cancer therapy target. To obtain novel PKM2 activators, we conducted a high-throughput screening (HTS)...
May 5, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28502727/concordance-between-research-sequencing-and-clinical-pharmacogenetic-genotyping-in-the-emerge-pgx-study
#3
Laura J Rasmussen-Torvik, Berta Almoguera, Kimberly F Doheny, Robert R Freimuth, Adam S Gordon, Hakon Hakonarson, Jared B Hawkins, Ammar Husami, Lynn Ivacic, Iftikhar J Kullo, Michael D Linderman, Teri A Manolio, Aniwaa O Obeng, Renata Pellegrino, Cynthia A Prows, Marylyn D Ritchie, Maureen Smith, Sarah C Stallings, Wendy A Wolf, Kejian Zhang, Stuart A Scott
There has been extensive debate about both the necessity of orthogonal confirmation of next-generation sequencing (NGS) results in Clinical Laboratory Improvement Amendments-approved laboratories and return of research NGS results to participants enrolled in research studies. In eMERGE-PGx, subjects underwent research NGS using PGRNseq and orthogonal targeted genotyping in clinical laboratories, which prompted a comparison of genotyping results between platforms. Concordance (percentage agreement) was reported for 4077 samples tested across nine combinations of research and clinical laboratories...
May 11, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28497464/in-vivo-proton-observed-carbon-edited-poce-13-c-magnetic-resonance-spectroscopy-of-the-rat-brain-using-a-volumetric-transmitter-and-receive-only-surface-coil-on-the-proton-channel
#4
Chathura Kumaragamage, Dan Madularu, Axel P Mathieu, Henk De Feyter, M Natasha Rajah, Jamie Near
PURPOSE: In vivo carbon-13 ((13) C) MR spectroscopy (MRS) is capable of measuring energy metabolism and neuroenergetics, noninvasively in the brain. Indirect ((1) H-[(13) C]) MRS provides sensitivity benefits compared with direct (13) C methods, and normally includes a (1) H surface coil for both localization and signal reception. The aim was to develop a coil platform with homogenous B1+ and use short conventional pulses for short echo time proton observed carbon edited (POCE) MRS. METHODS: A (1) H-[(13) C] MRS coil platform was designed with a volumetric resonator for (1) H transmit, and surface coils for (1) H reception and (13) C transmission...
May 12, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28496395/a-relative-quantitative-positive-negative-ion-switching-method-for-untargeted-lipidomics-via-high-resolution-lc-ms-ms-from-any-biological-source
#5
Susanne B Breitkopf, Stéphane J H Ricoult, Min Yuan, Ying Xu, David A Peake, Brendan D Manning, John M Asara
INTRODUCTION: Advances in high-resolution mass spectrometry have created renewed interest for studying global lipid biochemistry in disease and biological systems. OBJECTIVES: Here, we present an untargeted 30 min. LC-MS/MS platform that utilizes positive/negative polarity switching to perform unbiased data dependent acquisitions (DDA) via higher energy collisional dissociation (HCD) fragmentation to profile more than 1000-1500 lipid ions mainly from methyl-tert-butyl ether (MTBE) or chloroform:methanol extractions...
March 2017: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/28488437/strain-multiplexed-metasurface-holograms-on-a-stretchable-substrate
#6
Stephanie C Malek, Ho-Seok Ee, Ritesh Agarwal
We demonstrate reconfigurable phase-only computer-generated metasurface holograms with up to three image planes operating in the visible regime fabricated with gold nanorods on a stretchable polydimethylsiloxane substrate. Stretching the substrate enlarges the hologram image and changes the location of the image plane. Upon stretching, these devices can switch the displayed holographic image between multiple distinct images. This work opens up the possibilities for stretchable metasurface holograms as flat devices for dynamically reconfigurable optical communication and display...
May 10, 2017: Nano Letters
https://www.readbyqxmd.com/read/28470192/remote-carboxylation-of-halogenated-aliphatic-hydrocarbons-with-carbon-dioxide
#7
Francisco Juliá-Hernández, Toni Moragas, Josep Cornella, Ruben Martin
Catalytic carbon-carbon bond formation has enabled the streamlining of synthetic routes when assembling complex molecules. It is particularly important when incorporating saturated hydrocarbons, which are common motifs in petrochemicals and biologically relevant molecules. However, cross-coupling methods that involve alkyl electrophiles result in catalytic bond formation only at specific and previously functionalized sites. Here we describe a catalytic method that is capable of promoting carboxylation reactions at remote and unfunctionalized aliphatic sites with carbon dioxide at atmospheric pressure...
May 3, 2017: Nature
https://www.readbyqxmd.com/read/28464456/forward-backward-switching-of-plasmonic-wave-propagation-using-sign-reversal-coupling
#8
Zhen Gao, Fei Gao, Youming Zhang, Hongyi Xu, Yu Luo, Baile Zhang
Backward waves with wave-front propagation opposite in direction to that of energy flow have attracted considerable interest in the context of photonic metamaterials. However, switching between forward and backward waves in the same frequency range has remained a challenge. Here, on a platform of coupled designer surface plasmon resonators in the microwave regime, multiband forward/backward switching of plasmonic wave propagation is demonstrated. This approach makes use of sign-reversal coupling that occurs when switching the coupling configuration between tightly confined photonic modes...
May 2, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28459542/structure-of-rna-stem-loop-b-from-the-picornavirus-replication-platform
#9
Meghan S Warden, Marco Tonelli, Gabriel Cornilescu, Dong Liu, Lorelei J Hopersberger, Komala Ponniah, Steven M Pascal
The presumptive RNA cloverleaf at the start of the 5'-untranslated region of the picornavirus genome is an essential element in replication. Stem loop B (SLB) of the cloverleaf is a recognition site for the host polyC-binding protein, which initiates a switch from translation to replication. Here we present the solution structure of human rhinovirus isotype 14 SLB using nuclear magnetic resonance spectroscopy. SLB adopts a predominantly A-form helical structure. The stem contains five Watson-Crick base pairs and one wobble base pair and is capped by an eight-nucleotide loop...
May 5, 2017: Biochemistry
https://www.readbyqxmd.com/read/28452931/an-adaptive-b-spline-neural-network-and-its-application-in-terminal-sliding-mode-control-for-a-mobile-satcom-antenna-inertially-stabilized-platform
#10
Xiaolei Zhang, Yan Zhao, Kai Guo, Gaoliang Li, Nianmao Deng
The mobile satcom antenna (MSA) enables a moving vehicle to communicate with a geostationary Earth orbit satellite. To realize continuous communication, the MSA should be aligned with the satellite in both sight and polarization all the time. Because of coupling effects, unknown disturbances, sensor noises and unmodeled dynamics existing in the system, the control system should have a strong adaptability. The significant features of terminal sliding mode control method are robustness and finite time convergence, but the robustness is related to the large switching control gain which is determined by uncertain issues and can lead to chattering phenomena...
April 28, 2017: Sensors
https://www.readbyqxmd.com/read/28449282/organotitania-based-nanostructures-as-a-suitable-platform-for-the-implementation-of-binary-ternary-and-fuzzy-logic-systems
#11
Andrzej Blachecki, Justyna Mech-Piskorz, Marta Gajewska, Krzysztof Mech, Kacper Pilarczyk, Konrad Szacilowski
Titanium dioxide nanocomposites were synthesized in hierarchical architectures with the use of 1,4-dihydroxyanthraquinone photosensitizer. In the first step, the dye was either incorporated into the TiO2 core or adsorbed on its surface. In the subsequent phase, both structures were covered with an outer layer of titanium dioxide. The structure, morphology, aggregation, spectroscopic and electrochemical properties of the synthesized TiO2-based materials are presented with a special emphasis on the photosensitization and the photocurrent switching phenomena which are also discussed within the context of the optical logic gates implementation and fuzzy logic systems operation...
April 27, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28444822/triplex-dna-nanostructures-from-basic-properties-to-applications
#12
Yuwei Hu, Alessandro Cecconello, Andrea Idili, Francesco Ricci, Itamar Willner
Triplex nucleic acids attract recent interest as part of the rich "tool-box" of structures used to develop DNA-based nanostructures and materials. This review addresses the use of DNA triplexes to assemble sensing platforms and molecular switches. Furthermore, the pH-induced, switchable assembly and dissociation of triplex DNA-bridged nanostructures are presented. Specifically, the aggregation/deaggregation of nanoparticles and the reversible oligomerization of "origami" tiles or DNA circles are described. Also, the use of triplex-DNA structures as functional units to assemble pH-responsive systems and materials are presented...
April 26, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28444177/single-centre-experience-with-transapical-transcatheter-mitral-valve-implantation%C3%A2
#13
Gry Dahle, Kjell-Arne Rein, Arnt E Fiane
OBJECTIVES: A transcatheter heart valve technique can be used in failed mitral valve repairs with annuloplasty rings, deterioriated bioprostheses and in mitral annular calcification, all serving as 'docking stations' for balloon-expandable valves. Specially designed transcatheter mitral valve platforms are used in ongoing studies for native mitral valve regurgitation. We present our single centre experience with transcatheter mitral valve implantation-transapical approach procedures in eleven patients...
April 21, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28440073/antiparallel-dynamic-covalent-chemistries
#14
Bartosz M Matysiak, Piotr Nowak, Ivica Cvrtila, Charalampos G Pappas, Bin Liu, Dávid Komáromy, Sijbren Otto
The ability to design reaction networks with high, but addressable complexity is a necessary prerequisite to make advanced functional chemical systems. Dynamic combinatorial chemistry has proven to be a useful tool in achieving complexity, however with some limitations in controlling it. Herein we introduce the concept of antiparallel chemistries, in which the same functional group can be channeled into one of two reversible chemistries depending on a controllable parameter. Such systems allow both for achieving complexity, by combinatorial chemistry, and addressing it, by switching from one chemistry to another by controlling an external parameter...
May 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28429003/electrochemical-plasmonic-metamaterials-towards-fast-electro-tuneable-reflecting-nanoshutters
#15
Debabrata Sikdar, Alwin Bucher, Cristian Zagar, Alexei A Kornyshev
Self-assembling arrays of metallic nanoparticles at liquid|liquid or liquid|solid interfaces could deliver new platforms for tuneable optical systems. Such systems can switch between very-high and very-low reflectance states upon assembly and disassembly of nanoparticles at the interface, respectively. This encourages creation of electro-variably reversible mirror/window nanoplasmonic devices. However, the response time of these systems is usually limited by the rate-of-diffusion of the nanoparticles in the liquid, towards the interface and back...
April 21, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28427525/precision-medicine-for-early-breast-cancer-radiotherapy-opening-up-new-horizons
#16
REVIEW
Jacques Bernier
So far most efforts put forth to test the value of predictive and prognostic tools in the field of breast radiotherapy remained globally disappointing, or at least below the convincing levels reached for systemic therapy. Nevertheless the addition of predictive tools to the clinical armament tends to prevail over the use of the sole prognostic factors, also in radiotherapy. A number of predictive assays, clinically validated or not, have recently elicited significant associations between molecular profiles and tumor biological aggressiveness and/or radiosensitivity levels...
May 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28413592/marginal-bone-loss-around-platform-switched-and-non-platform-switched-implants-after-two-years-of-placement-a-clinical-trial
#17
Ali Zarandi, Maryam Novin
Background. The present study was conducted to investigate the marginal bone loss around two different types of implant‒abutment junctions, called platform-switched (Implantium system) and non-platform switched (XiVE system) after two years of loading. Methods. Sixty-four implants in 49 patients were included in the study. The implants were placed in the posterior mandibular region according to the relevant protocols. The extent of bone loss around the implants was measured and compared after 24 months, using digital parallel periapical radiographs...
2017: Journal of Dental Research, Dental Clinics, Dental Prospects
https://www.readbyqxmd.com/read/28394574/deterministic-switching-of-perpendicular-magnetic-anisotropy-by-voltage-control-of-spin-reorientation-transition-in-co-pt-3-pb-mg1-3nb2-3-o3-pbtio3-multiferroic-heterostructures
#18
Bin Peng, Ziyao Zhou, Tianxiang Nan, Guohua Dong, Mengmeng Feng, Qu Yang, Xinjun Wang, Shishun Zhao, Dan Xian, Zhuang-De Jiang, Wei Ren, Zuo-Guang Ye, Nian X Sun, Ming Liu
One of the central challenges in realizing multiferroics-based magnetoelectric memories is to switch perpendicular magnetic anisotropy (PMA) with a control voltage. In this study, we demonstrate electrical flipping of magnetization between the out-of-plane and the in-plane directions in (Co/Pt)3/(011) Pb(Mg1/3Nb2/3)O3-PbTiO3 multiferroic heterostructures through a voltage-controllable spin reorientation transition (SRT). The SRT onset temperature can be dramatically suppressed at least 200 K by applying an electric field, accompanied by a giant electric-field-induced effective magnetic anisotropy field (ΔHeff) up to 1100 Oe at 100 K...
April 25, 2017: ACS Nano
https://www.readbyqxmd.com/read/28383017/room-temperature-subnanosecond-waveguide-lasers-in-nd-yvo4-q-switched-by-phase-change-vo2-a-comparison-with-2d-materials
#19
Weijie Nie, Rang Li, Chen Cheng, Yanxue Chen, Qingming Lu, Carolina Romero, Javier R Vázquez de Aldana, Xiaotao Hao, Feng Chen
We report on room-temperature subnanosecond waveguide laser operation at 1064 nm in a Nd:YVO4 crystal waveguide through Q-switching of phase-change nanomaterial vanadium dioxide (VO2). The unique feature of VO2 nanomaterial from the insulating to metallic phases offers low-saturation-intensity nonlinear absorptions of light for subnanosecond pulse generation. The low-loss waveguide is fabricated by using the femtosecond laser writing with depressed cladding geometry. Under optical pump at 808 nm, efficient pulsed laser has been achieved in the Nd:YVO4 waveguide, reaching minimum pulse duration of 690 ps and maximum output average power of 66...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28380968/tin-diselenide-as-a-new-saturable-absorber-for-generation-of-laser-pulses-at-1%C3%AE-m
#20
Chen Cheng, Ziqi Li, Ningning Dong, Jun Wang, Feng Chen
The nonlinear optical responses of two-dimensional (2D) few-layer tin diselenide (SnSe<sub>2</sub>) have been investigated in this work. By applying the Z-scan technique, the saturable absorption of SnSe<sub>2</sub> thin film has been observed at a wavelength of ~1μm, which enables SnSe<sub>2,</sub> a new saturable absorber for pulsed laser generation. A detailed exploration of the nonlinear absorption of SnSe<sub>2</sub> film and their dependence on excitation pulse energy is carried out...
March 20, 2017: Optics Express
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