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https://www.readbyqxmd.com/read/28227876/a-dynamic-data-source-selection-system-for-smartwatch-platform
#1
Ebrahim Nemati, Konstantinos Sideris, Haik Kalantarian, Majid Sarrafzadeh, Ebrahim Nemati, Konstantinos Sideris, Haik Kalantarian, Majid Sarrafzadeh, Haik Kalantarian, Majid Sarrafzadeh, Konstantinos Sideris, Ebrahim Nemati
A novel data source selection algorithm is proposed for ambulatory activity tracking of elderly people. The algorithm introduces the concept of dynamic switching between the data collection modules (a smartwatch and a smartphone) to improve accuracy and battery life using contextual information. We show that by making offloading decisions as a function of activity, the proposed algorithm improves power consumption and accuracy of the previous work by 7 hours and 5% respectively compared to the baseline.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226575/wearable-ecg-platform-for-continuous-cardiac-monitoring
#2
S P Preejith, R Dhinesh, Jayaraj Joseph, Mohanasankar Sivaprakasam, S P Preejith, R Dhinesh, Jayaraj Joseph, Mohanasankar Sivaprakasam, R Dhinesh, Mohanasankar Sivaprakasam, S P Preejith, Jayaraj Joseph
An ultra-low power ECG platform for continuous and minimally intrusive monitoring for systems with minimal processing capabilities, is presented in this paper. The platform is capable of detecting abnormalities in the ECG signal by extracting and analyzing features related to various cardiac trends. The platform is built to continuously operate on any of the 12 leads and the presented work includes a single lead implementation that works on lead I or II. A single lead, wearable ECG patch that can detect rhythm based arrhythmias and continuously monitor beat-to-beat heart rate and respiratory rate has been developed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225598/novel-aptasensor-platform-based-on-ratiometric-surface-enhanced-raman-spectroscopy
#3
Yan Wu, Fubing Xiao, Zhaoyang Wu, Ruqin Yu
A novel aptasensor platform has been developed for quantitative detection of adenosine triphosphate (ATP) based on a ratiometric surface-enhanced Raman scattering (SERS) strategy. The thiolated 3'-Rox-labeled complementary DNA (cDNA) is first immobilized on the gold nanoparticle (AuNP) surface and then hybridizes with the 3'-Cy5-labeled ATP-binding aptamer probe (Cy5-aptamer) to form a rigid double-stranded DNA (dsDNA), in which the Cy5 and Rox Raman labels are used to produce the ratiometric Raman signals...
February 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28223408/inducing-circular-rna-formation-using-the-crispr-endoribonuclease-csy4
#4
Erin K Borchardt, Rita M Meganck, Heather A Vincent, Christopher B Ball, Silvia B V Ramos, Nathaniel J Moorman, William F Marzluff, Aravind Asokan
Circular RNAs (circRNAs) are highly stable, covalently closed RNAs that are regulated in a spatiotemporal manner and whose functions are largely unknown. These molecules have the potential to be incorporated into engineered systems with broad technological implications. Here we describe a switch for inducing backsplicing of an engineered circRNA that relies on the CRISPR endoribonuclease, Csy4, as an activator of circularization. The endoribonuclease activity and 3' end-stabilizing properties of Csy4 are particularly suited for this task...
February 21, 2017: RNA
https://www.readbyqxmd.com/read/28222606/flexible-porphyrinoids
#5
Bartosz Szyszko, Michał J Białek, Ewa Pacholska-Dudziak, Lechosław Latos-Grażyński
This review underscores the conformational flexibility of porphyrinoids, a unique class of functional molecules, starting from the smallest triphyrins(1.1.1) via [18]porphyrins(1.1.1.1) and concluding with a variety of expanded porphyrinoids and heteroporphyrinoids, including the enormous [96]tetracosaphyrin(1.0.1.0.1.0.1.0.1.0.1.0.1.0.1.0.1.0.1.0.1.0.1.0). The specific flexibility of porphyrinoids has been documented as instrumental in the designing or redesigning of macrocyclic frames, particularly in the search for adjustable platforms for coordination or organometallic chemistry, anion binding, or mechanistic switches in molecular devices...
February 22, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28220761/electrically-tunable-terahertz-polarization-converter-based-on-overcoupled-metal-isolator-metal-metamaterials-infiltrated-with-liquid-crystals
#6
Borislav Vasić, Dimitrios C Zografopoulos, Goran Isić, Romeo Beccherelli, Radoš Gajić
Large birefringence and its electrical modulation by means of Fréedericksz transition makes nematic liquid crystals (LCs) a promising platform for tunable terahertz (THz) devices. The thickness of standard LC cells is in the order of the wavelength, requiring high driving voltages and allowing only a very slow modulation at THz frequencies. Here, we first present the concept of overcoupled metal-isolator-metal (MIM) cavities that allow for achieving simultaneously both very high phase difference between orthogonal electric field components and large reflectance...
February 21, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28220481/does-max-open-up-a-new-avenue-for-meiotic-research
#7
REVIEW
Ayumu Suzuki, Masataka Hirasaki, Akihiko Okuda
Meiosis is a central event of sexual reproduction. Like somatic cells, germ cells conduct mitosis to increase their cell number, but unlike somatic cells, germ cells switch their cell division mode from mitosis to meiosis at a certain point in gametogenesis. However, the molecular basis of this switch remains elusive. In this review article, we give an overview of the onset of mammalian meiosis, including our recent finding that MYC Associated Factor X (MAX) prevents ectopic and precocious meiosis in embryonic stem cells (ESCs) and germ cells, respectively...
February 20, 2017: Development, Growth & Differentiation
https://www.readbyqxmd.com/read/28219544/the-society-of-thoracic-surgeons-congenital-heart-surgery-database-2017-update-on-outcomes-and-quality
#8
Jeffrey P Jacobs, John E Mayer, Constantine Mavroudis, Sean M O'Brien, Erle H Austin, Sara K Pasquali, Kevin D Hill, David M Overman, James D St Louis, Tara Karamlou, Christian Pizarro, Jennifer C Hirsch-Romano, Donna McDonald, Jane M Han, Susan Becker, Christo I Tchervenkov, Francois Lacour-Gayet, Carl L Backer, Charles D Fraser, James S Tweddell, Martin J Elliott, Hal Walters, Richard A Jonas, Richard L Prager, David M Shahian, Marshall L Jacobs
The Society of Thoracic Surgeons Congenital Heart Surgery Database is the largest congenital and pediatric cardiac surgical clinical data registry in the world. It is the platform for all activities of The Society of Thoracic Surgeons related to the analysis of outcomes and the improvement of quality in this subspecialty. This report summarizes current aggregate national outcomes in congenital and pediatric cardiac surgery and reviews related activities in the areas of quality measurement, performance improvement, and transparency...
March 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28210796/optogenetic-switches-for-light-controlled-gene-expression-in-yeast
#9
REVIEW
Francisco Salinas, Vicente Rojas, Verónica Delgado, Eduardo Agosin, Luis F Larrondo
Light is increasingly recognized as an efficient means of controlling diverse biological processes with high spatiotemporal resolution. Optogenetic switches are molecular devices for regulating light-controlled gene expression, protein localization, signal transduction and protein-protein interactions. Such molecular components have been mainly developed through the use of photoreceptors, which upon light stimulation undergo conformational changes passing to an active state. The current repertoires of optogenetic switches include red, blue and UV-B light photoreceptors and have been implemented in a broad spectrum of biological platforms...
February 16, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28208258/tuning-the-aggregation-disaggregation-behavior-of-graphene-quantum-dots-by-structure-switching-aptamer-for-high-sensitivity-fluorescent-ochratoxin-a-sensor
#10
Song Wang, Yajun Zhang, Guangsheng Pang, Yingwei Zhang, Shaojun Guo
The design of graphene quantum dots (GQDs)-aptamer bioconjugates as the new sensing platform is very important for developing high-sensitivity fluorescent biosensors; however, achieving new bioconjugates is still a great challenge. Herein, we report the development of a new high-sensitivity fluorescent aptasensor for the detection of ochratoxin A (OTA) based on tuning aggregation/disaggregation behavior of GQDs by structure-switching aptamers. The fluorescence sensing process for OTA detection involved two key steps: (1) cDNA-aptamer (cDNA, complementary to part of the OTA aptamer) hybridization induced the aggregation of GQD (fluorescence quenching) after cDNA was added into the GQDs-aptamer bioconjugate solution, and (2) the target of OTA triggered disaggregation of GQD aggregates (fluorescence recovery)...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28206745/atomistic-molecular-dynamics-simulations-of-mitochondrial-dna-polymerase-%C3%AE-novel-mechanisms-of-function-and-pathogenesis
#11
Liliya Euro, Outi Haapanen, Tomasz Róg, Ilpo Vattulainen, Anu Suomalainen, Vivek Sharma
DNA polymerase γ (Pol γ) is a key component of the mitochondrial DNA replisome and an important cause of neurological diseases. Despite the availability of its crystal structures, the molecular mechanism of DNA replication, the switch between polymerase and exonuclease activities, the site of replisomal interactions, and functional effects of patient mutations that do not affect direct catalysis have remained elusive. Here we report the first atomistic classical molecular dynamics simulations of the human Pol γ replicative complex...
February 23, 2017: Biochemistry
https://www.readbyqxmd.com/read/28205434/recent-advances-on-magnetic-relaxation-switching-assay-based-nanosensors
#12
Yang Zhang, Hong Yang, Zhiguo Zhou, Kai Huang, Shi-Ping Yang, Gang Han
Magnetic relaxation switching assay (MRSw)-based nanosensors respond to the changes of transverse relaxation time (T2) of water molecules resulted from the analyte-induced aggregation / disaggregation of magnetic nanoparticles (MNPs). This strategy has been widely applied to the detections of various substrates from heavy metal ions to organic pollutants, proteins, nucleic acids, bacteria/viruses, and specific cells. Compared with other nanosensors, MRSw-based nanosensors not only are free from the background interferences, signal bleaching, and quenching but also overcome light scattering from samples without pre-treatments...
February 16, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28184393/programmable-dna-triple-helix-molecular-switch-in-biosensing-applications-from-in-homogenous-solutions-to-in-living-cells
#13
Pinting Tang, Jing Zheng, Jianru Tang, Dandan Ma, Weijian Xu, Jishan Li, Zhong Cao, Ronghua Yang
Herein, we demonstrated a new gold nanoparticles (AuNPs)-integrated programmable triple-helix molecular switch (THMS) to realize the biosensing of multiple targets from in homogenous solution to in living cells. The results demonstrated that this proposed programmable THMS could be successfully used for imaging multiple messenger RNA (mRNA) in living cells and it significantly extends the scope of the THMS sensing platform.
February 10, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28181510/strong-coupling-and-high-contrast-all-optical-modulation-in-atomic-cladding-waveguides
#14
Liron Stern, Boris Desiatov, Noa Mazurski, Uriel Levy
In recent years, there has been marked increase in research aimed to introduce alkali vapours into guided-wave configurations. Owing to the significant reduction in device dimensions, the increase in density of states, the interaction with surfaces and primarily the high intensities carried along the structure, a plethora of light-vapour interactions can be studied. Moreover, such platform may exhibit new functionalities such as low-power nonlinear light-matter interactions. One immense challenge is to study the effects of quantum coherence and shifts in nanoscale waveguides, characterized by ultra-small mode areas and fast dynamics...
February 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28178904/cit-cus-fe3o4-based-and-enzyme-responsive-magnetic-nanoparticles-for-tumor-chemotherapy-photothermal-and-photodynamic-therapy
#15
Xiali Zhu, Heqing Huang, Yingjie Zhang, Huijuan Zhang, Lin Hou, Zhenzhong Zhang
Safe and efficient drug delivery in a controllable fashion, especially remote and repeatable switch of on-demand drug release, is the subject of widespread attention. A kind of magnetic nanoparticles (DOX-Cit/CuS@Fe3O4-NPs) simultaneously consisted of Cit/CuS@Fe3O4 and doxorubicin (DOX) was presented. The drug release from DOX-Cit/CuS@Fe3O4-NPs could be successfully triggered by the presence of gelatinase, showing great promise for tumor-targeted drug release through an enzymatic degradation mechanism. Compared with free DOX, DOX-Cit/CuS@Fe3O4-NPs could not only specially deliver Cit/CuS@Fe3O4 and DOX into MCF-7 cells, but also could greatly improve the quantity of ROS produced in MCF-7 cells under of 980 nm laser irradiation...
February 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28169506/a-combinational-effect-of-bulk-and-surface-shape-memory-transitions-on-the-regulation-of-cell-alignment
#16
Koichiro Uto, Takao Aoyagi, Cole A DeForest, Allan S Hoffman, Mitsuhiro Ebara
A novel shape-memory cell culture platform has been designed that is capable of simultaneously tuning surface topography and dimensionality to manipulate cell alignment. By crosslinking poly(ε-caprolactone) (PCL) macromonomers of precisely designed nanoarchitectures, a shape-memory PCL with switching temperature near body temperature is successfully prepared. The temporary strain-fixed PCLs are prepared by processing through heating, stretching, and cooling about the switching temperature. Temporary nanowrinkles are also formed spontaneously during the strain-fixing process with magnitudes that are dependent on the applied strain...
February 7, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28165234/reaching-across-the-divide-how-monometalation-of-one-binding-pocket-affects-the-empty-binding-pocket-in-a-siamese-twin-porphyrin-palladium-complex
#17
Anastasia Vogel, Sebastian Dechert, Christian Brückner, Franc Meyer
Siamese-twin porphyrin is a pyrazole-containing expanded porphyrin incorporating two porphyrin-like binding pockets. The macrocycle, however, does not possess an aromatic π system but rather two separated conjugation pathways that are isolated by the pyrazole junctions. Mono- and bimetallic complexes of the Siamese-twin porphyrin are known. This work addresses in detail the electronic consequences that monometalation (with Pd(II)) has on the electronic properties of the nonmetalated binding pocket by studying the solid-state structure, acid/base, and electrochemical properties of the monopalladium twin-porphyrin complex...
February 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28158307/aspasia-a-toolkit-for-evaluating-the-effects-of-biological-interventions-on-sbml-model-behaviour
#18
Stephanie Evans, Kieran Alden, Lourdes Cucurull-Sanchez, Christopher Larminie, Mark C Coles, Marika C Kullberg, Jon Timmis
A calibrated computational model reflects behaviours that are expected or observed in a complex system, providing a baseline upon which sensitivity analysis techniques can be used to analyse pathways that may impact model responses. However, calibration of a model where a behaviour depends on an intervention introduced after a defined time point is difficult, as model responses may be dependent on the conditions at the time the intervention is applied. We present ASPASIA (Automated Simulation Parameter Alteration and SensItivity Analysis), a cross-platform, open-source Java toolkit that addresses a key deficiency in software tools for understanding the impact an intervention has on system behaviour for models specified in Systems Biology Markup Language (SBML)...
February 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28157990/low-power-consumption-and-continuously-tunable-all-optical-microwave-filter-based-on-an-opto-mechanical-microring-resonator
#19
Li Liu, Yue Yang, Zhihua Li, Xing Jin, Wenqin Mo, Xing Liu
We propose and experimentally demonstrate a continuously tunable all-optical microwave filter using a silicon opto-mechanical microring resonator (MRR). By finely adjusting the pump light with submilliwatt power level, transmission spectrum of the MRR could be continuously shifted based on the nonlinear effects, including the opto-mechanical effect and thermo-optic effect. Therefore, in the case of optical single sideband (OSSB) modulation, the frequency intervals between the optical carrier (near one MRR resonance) and the corresponding resonance could be flexibly manipulated, which is the critical factor to achieve continuously tunable microwave photonic filter (MPF)...
January 23, 2017: Optics Express
https://www.readbyqxmd.com/read/28155937/controlled-aggregation-and-cell-uptake-of-thermoresponsive-polyoxazoline-grafted-superparamagnetic-iron-oxide-nanoparticles
#20
Steffen Kurzhals, Noga Gal, Ronald Zirbs, Erik Reimhult
Hydrophilic polymer-coated iron oxide nanoparticles are potential materials for a plethora of applications in the biotechnological field. Typical such polymers, e.g. dextran or poly(ethylene glycol), lack the ability to tailor the biological response to an environmental trigger, while common responsive polymers such as poly(N-isopropylacrylamide) or poly(acrylic acid) are not suitable for biomedical applications. We present the synthesis and characterization of superparamagnetic iron oxide nanoparticles with thermoresponsive polyoxazoline brushes grafted at unprecedented density using nitrodopamine anchor chemistry...
February 3, 2017: Nanoscale
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