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Platform switching

Jamison Sloan, Nicholas Rivera, Marin Soljacic, Ido Kaminer
Control over the spontaneous emission of light through tailored optical environments remains a fundamental paradigm in nanophotonics. The use of highly-confined plasmons in materials such as graphene provide a promising platform to enhance transition rates in the IR-THz by many orders of magnitude. However, such enhancements involve near-field plasmon modes or other kinds of near-field coupling like quenching, and it is challenging to use these highly confined modes to harness light in the far-field due to the difficulty of plasmonic outcoupling...
December 14, 2017: Nano Letters
Igor B Sivaev
Design of rotatory molecular switches based on extremely stable sandwich organometallic complexes ferrocene and bis(dicarbollide) complexes of transition metals is reviewed. The "on"-"off" switching in these systems can be controlled by various external stimuli such as change of the solution pH, interactions with coordinating species or redox reactions involving the central atom or substituents in the ligands.
December 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Jiang-Yang Shao, Zhong-Liang Gong, Yu-Wu Zhong
Four bridged cyclometalated diruthenium systems are highlighted in this Frontier article, including strongly-coupled diruthenium complexes with a short phen-1,4-diyl or a planar pyren-2,7-diyl bridge, redox asymmetric diruthenium complexes characterized by different terminal ligands on the two ends, diruthenium complexes with a urea bridge that allows modulating the degree of electronic coupling, and those with a redox-active amine bridge with varying electronic structures. These complexes posess redox couples with low potentials and intense intervalence charge transfer absorptions in the near-infrared region in the one-electron-oxidized mixed-valent state...
December 12, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Martin J Taylor, Li Jiang, Joachim Reichert, Anthoula C Papageorgiou, Simon K Beaumont, Karen Wilson, Adam F Lee, Johannes V Barth, Georgios Kyriakou
Furfural is a key bioderived platform chemical whose reactivity under hydrogen atmospheres affords diverse chemical intermediates. Here, temperature-programmed reaction spectrometry and complementary scanning tunneling microscopy (STM) are employed to investigate furfural adsorption and reactivity over a Pt(111) model catalyst. Furfural decarbonylation to furan is highly sensitive to reaction conditions, in particular, surface crowding and associated changes in the adsorption geometry: furfural adopts a planar geometry on clean Pt(111) at low coverage, tilting at higher coverage to form a densely packed furfural adlayer...
April 20, 2017: Journal of Physical Chemistry. C, Nanomaterials and Interfaces
Juan Blanco, Alexandre Pico, Leticia Caneiro, Lourdes Nóvoa, Pilar Batalla, Pablo Martín-Lancharro
OBJECTIVE: The aim of this randomized clinical trial was to compare the effect on the interproximal implant bone loss (IBL) of two different heights (1 and 3 mm) of definitive abutments placed at bone level implants with a platform switched design. MATERIAL AND METHODS: Twenty-two patients received forty-four implants (6.5-10 mm length and 3.5-4 mm diameter) to replace at least two adjacent missing teeth, one bridge set to each patient-two implants per bridge...
December 8, 2017: Clinical Oral Implants Research
Sibo Guo, Hiroki Kamite, Nozomu Suzuki, Laibing Wang, Asuka Ohkubo, Michiya Fujiki
We investigated whether helicity and/or chirality of cellulose tris(phenylcarbamate) (CTPC) can transfer to non-charged, non-helical oligo- and polyfluorenes (F3, F5, F7, PF6, and PF8, Chart 1) when CTPC was employed as a solution processable homochiral platform of a D-glucose-skeletal polymer. Noticeably, CTPC revealed the solvent-driven, ambidextrous intermolecular helicity/chirality transfer capability to these fluorenes. The chiroptical inversion characteristics of circularly polarized luminescence (CPL) and the corresponding CD spectra were realized by solely choosing a proper achiral solvents and/or achiral cosolvents...
December 8, 2017: Biomacromolecules
A R Wijsmuller, L G C Romagnolo, V Agnus, C Giraudeau, A G F Melani, B Dallemagne, J Marescaux
BACKGROUND: Stereotactic navigation could improve the quality of surgery for rectal cancer. Critical challenges related to soft tissue stereotactic pelvic navigation include the potential difference in patient anatomy between intraoperative lithotomy and preoperative supine position for imaging. The objective of this study was to determine the difference in patient anatomy, sacral tilt, and skin fiducial position between these different patient positions and to investigate the feasibility and optimal set-up for stereotactic pelvic navigation...
December 6, 2017: Surgical Endoscopy
Ciyuan Qiu, Yuxing Yang, Chao Li, Yifang Wang, Kan Wu, Jianping Chen
All-optical signal processing avoids the conversion between optical signals and electronic signals and thus has the potential to achieve a power efficient photonic system. Micro-scale all-optical devices for light manipulation are the key components in the all-optical signal processing and have been built on the semiconductor platforms (e.g., silicon and III-V semiconductors). However, the two-photon absorption (TPA) effect and the free-carrier absorption (FCA) effect in these platforms deteriorate the power handling and limit the capability to realize complex functions...
December 6, 2017: Scientific Reports
Khulan Sergelen, Christian Petri, Ulrich Jonas, Jakub Dostalek
The preparation and investigation of a free-standing membrane made from a composite of thermoresponsive poly(N-isopropylacrylamide) (pNIPAAm) and polystyrene nanoparticles (PS NP) with temperature-controlled permeability is reported. The method exploits the light-induced crosslinking of the photo-reactive pNIPAAm-based polymer and mechanical reinforcement of the membrane structure by the polystyrene nanoparticles. About micrometer thick layers were either directly attached to a gold surface or prepared as free-standing layers spanning over arrays of microfluidic channels with a width of about hundred microns by using template stripping...
December 6, 2017: Biointerphases
Eisner Salamanca, Jerry C-Y Lin, Chi-Yang Tsai, Yung-Szu Hsu, Haw-Ming Huang, Nai-Chia Teng, Peter D Wang, Sheng-Wei Feng, May-Show Chen, Wei-Jen Chang
The benefits and feasibility of platform switching have been discussed in several studies, reporting lesser crestal bone loss in platform-switched implants than in platform-matched implants. Objective. The aim of the present study was to observe the changes in vertical and horizontal marginal bone levels in platform-switched and platform-matched dental implants. Materials and Methods. 51 patients received 60 dental implants in the present study over a 1-year period. Measurement was performed between the implant shoulder and the most apical and horizontal marginal defect by periapical radiographs to examine the changes of peri-implant alveolar bone before and 12 months after prosthodontic restoration delivery...
2017: BioMed Research International
David Ausländer, Simon Ausländer, Xavier Pierrat, Leon Hellmann, Leila Rachid, Martin Fussenegger
Synthetic biologists have advanced the design of trigger-inducible gene switches and their assembly into input-programmable circuits that enable engineered human cells to perform arithmetic calculations reminiscent of electronic circuits. By designing a versatile plug-and-play molecular-computation platform, we have engineered nine different cell populations with genetic programs, each of which encodes a defined computational instruction. When assembled into 3D cultures, these engineered cell consortia execute programmable multicellular full-adder logics in response to three trigger compounds...
December 4, 2017: Nature Methods
Fangli Zhao, Aurelio Bonasera, Ulrich Nöchel, Marc Behl, David Bléger
Hydrogels are soft materials that have found multiple applications in biomedicine and represent a good platform for the introduction of molecular switches and synthetic machines into macromolecular networks. Tuning their mechanical properties reversibly with light is appealing for a variety of advanced applications and has been demonstrated in the past; however, their activation typically requires the use of UV light, which displays several drawbacks related to its damaging character and limited penetration in tissues and materials...
November 30, 2017: Macromolecular Rapid Communications
Won-Seok Kim, Pengcheng Zeng, Jian Qing Shi, Youngjo Lee, Nam-Jong Paik
Motion analysis of the hyoid bone via videofluoroscopic study has been used in clinical research, but the classical manual tracking method is generally labor intensive and time consuming. Although some automatic tracking methods have been developed, masked points could not be tracked and smoothing and segmentation, which are necessary for functional motion analysis prior to registration, were not provided by the previous software. We developed software to track the hyoid bone motion semi-automatically. It works even in the situation where the hyoid bone is masked by the mandible and has been validated in dysphagia patients with stroke...
2017: PloS One
Stephen M Arpadi, Stephanie Shiau, Eduarda Pimentel De Gusmao, Avy Violari
INTRODUCTION: The objective of this commentary is to review considerations for implementing routine viral load (VL) monitoring programmes for HIV-infected infants and children living in low- and middle-income countries (LMIC). Since 2013, the World Health Organization (WHO) guidelines recommend VL testing as the preferred monitoring approach for all individuals treated with ART in order to assess treatment response, detect treatment failure and determine the need to switch to a second-line regimen in a timely manner...
November 2017: Journal of the International AIDS Society
Christoph Ogris, Dimitri Guala, Mateusz Kaduk, Erik L L Sonnhammer
This release of the FunCoup database ( is the fourth generation of one of the most comprehensive databases for genome-wide functional association networks. These functional associations are inferred via integrating various data types using a naive Bayesian algorithm and orthology based information transfer across different species. This approach provides high coverage of the included genomes as well as high quality of inferred interactions. In this update of FunCoup we introduce four new eukaryotic species: Schizosaccharomyces pombe, Plasmodium falciparum, Bos taurus, Oryza sativa and open the database to the prokaryotic domain by including networks for Escherichia coli and Bacillus subtilis...
November 20, 2017: Nucleic Acids Research
Pierre Parrend, Timothée Mazzucotelli, Florent Colin, Pierre Collet, Jean-Louis Mandel
Cohort Study Platforms (CSP) are emerging as a key tool for collecting patient information, providing new research data, and supporting family and patient associations. However they pose new ethics and regulatory challenges since they cross the gap between patients and medical practitioners. One of the critical issues for CSP is to enforce a strict control on access privileges whilst allowing the users to take advantage of the breadth of the available data. We propose Cerberus, a new access control scheme spanning the whole life-cycle of access right management: design, implementation, deployment and maintenance, operations...
November 16, 2017: Journal of Medical Systems
Shu Cheng, Katie Caviness, Jason Buehler, Megan Smithey, Janko Nikolich-Žugich, Felicia Goodrum
The transcriptional program associated with herpesvirus latency and the viral genes regulating entry into and exit from latency are poorly understood and controversial. Here, we developed and validated a targeted enrichment platform and conducted large-scale transcriptome analyses of human cytomegalovirus (HCMV) infection. We used both an experimental hematopoietic cell model of latency and cells from naturally infected, healthy human subjects (clinical) to define the breadth of viral genes expressed. The viral transcriptome derived from experimental infection was highly correlated with that from clinical infection, validating our experimental latency model...
November 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
Amanda Remorino, Simon De Beco, Fanny Cayrac, Fahima Di Federico, Gaetan Cornilleau, Alexis Gautreau, Maria Carla Parrini, Jean-Baptiste Masson, Maxime Dahan, Mathieu Coppey
Rac1 is a small RhoGTPase switch that orchestrates actin branching in space and time and protrusion/retraction cycles of the lamellipodia at the cell front during mesenchymal migration. Biosensor imaging has revealed a graded concentration of active GTP-loaded Rac1 in protruding regions of the cell. Here, using single-molecule imaging and super-resolution microscopy, we show an additional supramolecular organization of Rac1. We find that Rac1 partitions and is immobilized into nanoclusters of 50-100 molecules each...
November 14, 2017: Cell Reports
Yuya Sasada, David L Cochran
Clinicians very often have seen marginal bone loss around dental implants at the crest level early on after implant placement and uncovering. Early clinical publications had suggested that this bone loss occurred during the first year of loading. Thus, numerous attempts have been made to minimize or eliminate such bone loss. However, the timing and reason for this bone loss are not always apparent. The objective of this study was to review the evidence regarding marginal bone loss around dental implants from the standpoint of biologic consequences to help understand marginal bone changes around dental implants...
November 2017: International Journal of Oral & Maxillofacial Implants
Ochan Otim
Studying the formation of endoskeleton in many species is complex and difficult. The sea urchin embryo offers an unparalleled platform for understanding this process because of the ease with which its skeletogenic mesenchyme cells can be manipulated. In this study, preliminary evidence from biochemical studies towards understanding the role of the Onecut transcription factor during sea urchin skeletogenic mesenchyme cell specification is presented. Based on the evidence, an empirical model is proposed showing how Onecut, together with associated co-factors, may be using the C-element of the SM50 gene regulatory region in advance of the sea urchin Strongylocentrotus purpuratus spicule development...
2017: International Journal of Developmental Biology
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