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https://www.readbyqxmd.com/read/27908759/cathepsin-nanofiber-substrates-as-potential-agent-for-targeted-drug-delivery
#1
Yael Ben-Nun, Galit Fichman, Lihi Adler-Abramovich, Boris Turk, Ehud Gazit, Galia Blum
The development of reactive drug carriers that could actively respond to biological signals is a challenging task. Different peptides can self-assemble into biocompatible nanostructures of various functionalities, including drugs carriers. Minimal building blocks, such as diphenylalanine, readily form ordered nanostructures. Here we present development of self-assembled tetra-peptides that include the diphenylalanine motif, serving as substrates of the cathepsin proteases. This is of great clinical importance as cathepsins, whose activity and expression are highly elevated in cancer and other pathologies, have been shown to serve as efficient enzymes for therapeutic release...
November 28, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27906352/tunable-pancharatnam-berry-metasurface-for-dynamical-and-high-efficiency-anomalous-reflection
#2
He-Xiu Xu, Guang-Ming Wang, Tong Cai, Jun Xiao, Ya-Qiang Zhuang
Pancharatnam-Berry (PB) metasurfaces have intrigued a great deal of interest in recent years for anomalous reflection/refraction, vortex plate, orbital angular momentum, flat lens, photonic spin hall effect (PSHE), holograms and reflect/transmit arrays. However, almost all designs are restricted to fixed electrical performance/functionality once the design is finished. Here, we report for the first time a strategy for PB metasurface with agile working frequency by involving each meta-atom with tunable PIN diodes...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27905067/mathematical-model-of-bone-remodeling-captures-the-antiresorptive-and-anabolic-actions-of-various-therapies
#3
David S Ross, Khamir Mehta, Antonio Cabal
A better understanding of the molecular pathways regulating the bone remodeling process should help in the development of new antiresorptive regulators and anabolic regulators, that is, regulators of bone resorption and of bone formation. Understanding the mechanisms by which parathyroid hormone (PTH) influences bone formation and how it switches from anabolic to catabolic action is important for treating osteoporosis (Poole and Reeve in Curr Opin Pharmacol 5:612-617, 2005). In this paper we describe a mathematical model of bone remodeling that incorporates, extends, and integrates several models of particular aspects of this biochemical system (Cabal et al...
November 30, 2016: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/27883203/impact-of-platform-switching-on-interproximal-bone-levels-around-8-5-mm-implants-in-the-posterior-region-5-year-results-from-a-randomized-clinical-trial
#4
Gerdien Telleman, Gerry M Raghoebar, Arjan Vissink, Henny J A Meijer
AIM: To assess the medium-term results of 8.5 mm implants supplied with a conventional platform-matched implant-abutment connection or a platform-switched design. MATERIALS & METHODS: Eighty patients with 1 or more missing teeth in the maxillary or mandibular posterior zone were randomly assigned for treatment with implants with a conventional (control group) or platform-switched (test group) implant-abutment connection. Follow-up visits were conducted 1 month, 1 year and 5 years after functional loading...
November 24, 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27875979/self-assembled-nucleic-acid-nanostructures-for-cancer-theranostic-medicines
#5
Jinglin Fu, Gabriele Stankeviciute, Sung Won Oh, John Collins, Yinghui Zhong, Ting Zhang
Theranostic medicine has become more promising in cancer treatment, where the cancer diagnosis and chemotherapy are combined for early diagnosis and precise treatment with improved efficacy and reduced side effects. Nanotechnology has played a critical role in developing various nanomaterials with engendered smart functions and targeted delivery. The rapid development of structural DNA nanotechnology has enabled the design and fabrication of complex nanostructures with prescribed 1D, 2D and 3D patterns in vitro and in vivo...
November 22, 2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/27874855/conditional-control-of-suicide-gene-expression-in-tumor-cells-with-theophylline-responsive-ribozyme
#6
Y Zhang, J Wang, H Cheng, Y Sun, M Liu, Z Wu, R Pei
Numerous synthetic RNA-based controls for integrating sensing switches with function devices have been demonstrated in a variety of organisms for gene regulatory. Although potential advantages of RNA-based genetic control strategies have been shown in clinical applications, successful extending these engineered systems into medical applications has seldom reported. Here, a synthetic RNA-based ribozyme system and its application in advancing rationally designed cellular therapy were described. The theophylline-responsive ribozyme-based device provided a powerful platform for suicide gene expression regulation in tumor cells...
November 22, 2016: Gene Therapy
https://www.readbyqxmd.com/read/27869821/synthetic-recording-and-in-situ-readout-of-lineage-information-in-single-cells
#7
Kirsten L Frieda, James M Linton, Sahand Hormoz, Joonhyuk Choi, Ke-Huan K Chow, Zakary S Singer, Mark W Budde, Michael B Elowitz, Long Cai
Reconstructing the lineage relationships and dynamic event histories of individual cells within their native spatial context is a long-standing challenge in biology. Many biological processes of interest occur in optically opaque or physically inaccessible contexts, necessitating approaches other than direct imaging. Here, we describe a new synthetic system that enables cells to record lineage information and event histories in the genome in a format that can be subsequently read out in single cells in situ...
November 21, 2016: Nature
https://www.readbyqxmd.com/read/27869177/repressor-logic-modules-assembled-by-rolling-circle-amplification-platform-to-construct-a-set-of-logic-gates
#8
Hua Wei, Bo Hu, Suming Tang, Guojie Zhao, Yifu Guan
Small molecule metabolites and their allosterically regulated repressors play an important role in many gene expression and metabolic disorder processes. These natural sensors, though valuable as good logic switches, have rarely been employed without transcription machinery in cells. Here, two pairs of repressors, which function in opposite ways, were cloned, purified and used to control DNA replication in rolling circle amplification (RCA) in vitro. By using metabolites and repressors as inputs, RCA signals as outputs, four basic logic modules were constructed successfully...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27861512/a-rapid-response-humoral-vaccine-platform-exploiting-pre-existing-non-cognate-populations-of-anti-vaccine-or-anti-viral-cd4-t-helper-cells-to-confirm-b-cell-activation
#9
Thomas Hills, Phillip G Jakeman, Robert C Carlisle, Paul Klenerman, Leonard W Seymour, Ryan Cawood
The need for CD4+ T cell responses to arise de novo following vaccination can limit the speed of B cell responses. Populations of pre-existing vaccine-induced or anti-viral CD4+ T cells recognising distinct antigens could be exploited to overcome this limitation. We hypothesise that liposomal vaccine particles encapsulating epitopes that are recognised, after processing and B cell MHCII presentation, by pre-existing CD4+ T cells will exploit this pre-existing T cell help and result in improved antibody responses to distinct target antigens displayed on the particle surface...
2016: PloS One
https://www.readbyqxmd.com/read/27859710/rapid-continuous-multimaterial-extrusion-bioprinting
#10
Wanjun Liu, Yu Shrike Zhang, Marcel A Heinrich, Fabio De Ferrari, Hae Lin Jang, Syeda Mahwish Bakht, Mario Moisés Alvarez, Jingzhou Yang, Yi-Chen Li, Grissel Trujillo-de Santiago, Amir K Miri, Kai Zhu, Parastoo Khoshakhlagh, Gyan Prakash, Hao Cheng, Xiaofei Guan, Zhe Zhong, Jie Ju, Geyunjian Harry Zhu, Xiangyu Jin, Su Ryon Shin, Mehmet Remzi Dokmeci, Ali Khademhosseini
The development of a multimaterial extrusion bioprinting platform is reported. This platform is capable of depositing multiple coded bioinks in a continuous manner with fast and smooth switching among different reservoirs for rapid fabrication of complex constructs, through digitally controlled extrusion of bioinks from a single printhead consisting of bundled capillaries synergized with programmed movement of the motorized stage.
November 17, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27836602/a-biomimetic-bioelectronic-tongue-a-switch-for-on-and-off-response-of-acid-sensations
#11
Wei Zhang, Peihua Chen, Lianqun Zhou, Zhen Qin, Keqiang Gao, Jia Yao, Chuanyu Li, Ping Wang
The perception of sour taste in mammals is important for its basic modality properties and avoiding toxic substances. We explore a biomimetic bioelectronic tongue, which integrate MEA (microelectrode array) and taste receptor cell for acid detection as a switch. However, the acid-sensing mechanism and coding of the taste receptor cells in the periphery is not well understood, with long-standing debate. Therefore, we firstly construct a Hodgkin-Huxley type mathematical model of whole-cell acid-sensing taste receptor cells based on the electrophysiologic patch clamp recordings with different acid sensitive receptor expressing and different acidic stimulations...
October 27, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27834972/tunable-multicolor-emissions-in-a-monocomponent-gel-system-by-varying-the-solvent-temperature-and-fluoride-anion
#12
Xuelei Pang, Xudong Yu, Dongyan Xie, Yajuan Li, Lijun Geng, Jujie Ren, Xiaoli Zhen
The facile tuning of the fluorescent properties of organogels is highly desirable for optical switches, light-emitting diodes, chemosensors and bioprobes. The design of organic molecules with multiple emission colors but only one molecular platform remains challenging. Herein, a new cholesterol-based organogelator N1 containing D-A pairs (salicylaldehyde and naphthalimide units) was designed. We successfully obtained multiple solvent-tuned emission colors in both the solution and gel states using a unimolecular platform...
November 11, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27833729/the-prosthetic-influence-and-biomechanics-on-peri-implant-strain-a-systematic-literature-review-of-finite-element-studies
#13
REVIEW
Julius Maminskas, Algirdas Puisys, Ritva Kuoppala, Aune Raustia, Gintaras Juodzbalys
OBJECTIVES: To systematically review risks of mechanical impact on peri-implant strain and prosthetic influence on stability across finite element studies. MATERIAL AND METHODS: An online literature search was performed on MEDLINE and EMBASE databases published between 2011 and 2016. Following keywords tiered screening and selection of the title, abstract and full-text were performed. Studies of finite element analysis (FEA) were considered for inclusion that were written in English and revealed stress concentrations or strain at peri-implant bone level...
July 2016: Journal of Oral & Maxillofacial Research
https://www.readbyqxmd.com/read/27818950/type-three-secretion-system-in-attaching-and-effacing-pathogens
#14
REVIEW
Meztlli O Gaytán, Verónica I Martínez-Santos, Eduardo Soto, Bertha González-Pedrajo
Enteropathogenic Escherichia coli and enterohemorrhagic E. coli are diarrheagenic bacterial human pathogens that cause severe gastroenteritis. These enteric pathotypes, together with the mouse pathogen Citrobacter rodentium, belong to the family of attaching and effacing pathogens that form a distinctive histological lesion in the intestinal epithelium. The virulence of these bacteria depends on a type III secretion system (T3SS), which mediates the translocation of effector proteins from the bacterial cytosol into the infected cells...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27816590/a-fluorescence-biosensor-for-vegf-detection-based-on-dna-assembly-structure-switching-and-isothermal-amplification
#15
Junlong Li, Kexin Sun, Zhongping Chen, Jifei Shi, Dandan Zhou, Guoming Xie
Vascular endothelial growth factor (VEGF) is an important biomarker in cancer angiogenesis. Here, we develop a aptasensor method for VEGF detection based on DNA assembly structure switching and isothermal amplification. The design employs a DNA assembly made of a isothermal amplification template, a aptamer, a primer and a protector chain. The DNA assembly is unable to undergo isothermal amplification in the absence of target. The presence of the target, however, triggers a structure switching event that causes hybridization of primer with template to facilitate isothermal amplification...
September 30, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27815447/efficient-culture-of-human-naive-and-memory-b-cells-for-use-as-apcs
#16
Kuei-Ying Su, Akiko Watanabe, Chen-Hao Yeh, Garnett Kelsoe, Masayuki Kuraoka
The ability to culture and expand B cells in vitro has become a useful tool for studying human immunity. A limitation of current methods for human B cell culture is the capacity to support mature B cell proliferation. We developed a culture method to support the efficient activation and proliferation of naive and memory human B cells. This culture supports extensive B cell proliferation, with ∼10(3)-fold increases following 8 d in culture and 10(6)-fold increases when cultures are split and cultured for 8 more days...
November 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27807750/biobanks-and-their-clinical-application-and-informatics-challenges
#17
Lan Yang, Yalan Chen, Chunjiang Yu, Bairong Shen
Biobanks are one of the most important biomedical research resources and contribute to the development of biomarker detection, molecular diagnosis, translational medicine, and multidisciplinary disease research, as well as studies of interactions between genetic and environmental or lifestyle factors. Aiming for the wide clinical application of biobanks, biobanking efforts have recently switched from a focus on accumulating samples to both formalizing and sustaining collections in light of the rapid progress in the fields of personalized medicine and bioinformatics analysis...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27779408/molecular-mechanism-behind-solvent-concentration-dependent-optimal-activity-of-thermomyces-lanuginosus-lipase-in-biocompatible-ionic-liquid-interfacial-activation-through-arginine-switch
#18
Sudip Das, Tarak Karmakar, Sundaram Balasubramanian
Thermomyces lanuginosus lipase (TLL) is an industrially significant catalyst for the production of biodiesel due to its operability over a wide range of pH and temperature. Molecular dynamics simulations of TLL in aqueous solutions of a biocompatible ionic liquid (IL), cholinium glycinate (ChGly) have been carried out to investigate the microscopic reasons for the experimentally observed enhancement in the activity of TLL, upon addition of room temperature IL, especially at an optimal concentration. Eight different TLL systems in both its open and closed forms at various concentrations of the room temperature IL in water have been studied...
October 25, 2016: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/27778512/multifunctional-gold-nanoclusters-based-nanosurface-energy-transfer-probe-for-real-time-monitoring-of-cell-apoptosis-and-self-evaluating-of-pro-apoptotic-theranostics
#19
Yong Li, Pei Li, Rong Zhu, Chao Luo, Hao Li, Shanfang Hu, Zhou Nie, Yan Huang, Shouzhuo Yao
Bio-imaging probes for accurately monitoring apoptosis process have extensive significance for cell biological studies and clinical investigations. Herein, a novel multi-functional peptide-tailored gold nanoclusters (AuNCs) has been developed for real-time imaging of caspase-indicated cell apoptosis. The AuNCs nanoprobe was facilely prepared by a one-step peptide-mediated biomineralization with the dye (TRAMA)-tagged peptides specific to caspase 3 as both template agents and the signal switch. Unlike conventional FRET-based fluorescent probes of caspase activity, these nanoprobes relied on the unique quenching effect of AuNCs through the nanosurface energy transfer (NSET) from dye to AuNCs...
October 25, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27774349/a-two-metal-ion-mediated-conformational-switching-pathway-for-hdv-ribozyme-activation
#20
Tai-Sung Lee, Brian K Radak, Michael E Harris, Darrin M York
RNA enzymes serve as a potentially powerful platform from which to design catalysts and engineer new biotechnology. A fundamental understanding of these systems provides insight to guide design. The hepatitis delta virus ribozyme (HDVr) is a small, self-cleaving RNA motif widely distributed in nature, that has served as a paradigm for understanding basic principles of RNA catalysis. Nevertheless, questions remain regarding the precise roles of divalent metal ions and key nucleotides in catalysis. In an effort to establish a reaction mechanism model consistent with available experimental data, we utilize molecular dynamics simulations to explore different conformations and metal ion binding modes along the HDVr reaction path...
2016: ACS Catalysis
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