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https://www.readbyqxmd.com/read/28820971/ultrasensitive-detection-of-ag-i-based-on-the-conformational-switching-of-a-multifunctional-aptamer-probe-induced-by-silver-i
#1
Yu-Feng Zhu, Yong-Sheng Wang, Bin Zhou, Yan-Qin Huang, Xue-Jiao Li, Si-Han Chen, Xiao-Feng Wang, Xian Tang
We for the first time confirmed that the low concentrations of Ag(I) could induce a silver specific aptamer probe (SAP) from a random coil sequence form to G-quadruplex structure. Thereby, a novel highly sensitive fluorescence strategy for silver(I) assay was established. The designed multifunctional SAP could act as a recognition element for Ag(I) and a signal reporter. The use of such a SAP can ultrasensitively and selectively detect Ag(I), giving a detection limit down to 0.64nM. This is much lower than those reported by related literatures...
August 10, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28819184/black-phosphorus-ink-formulation-for-inkjet-printing-of-optoelectronics-and-photonics
#2
Guohua Hu, Tom Albrow-Owen, Xinxin Jin, Ayaz Ali, Yuwei Hu, Richard C T Howe, Khurram Shehzad, Zongyin Yang, Xuekun Zhu, Robert I Woodward, Tien-Chun Wu, Henri Jussila, Jiang-Bin Wu, Peng Peng, Ping-Heng Tan, Zhipei Sun, Edmund J R Kelleher, Meng Zhang, Yang Xu, Tawfique Hasan
Black phosphorus is a two-dimensional material of great interest, in part because of its high carrier mobility and thickness dependent direct bandgap. However, its instability under ambient conditions limits material deposition options for device fabrication. Here we show a black phosphorus ink that can be reliably inkjet printed, enabling scalable development of optoelectronic and photonic devices. Our binder-free ink suppresses coffee ring formation through induced recirculating Marangoni flow, and supports excellent consistency (< 2% variation) and spatial uniformity (< 3...
August 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28817742/minimum-abutment-height-to-eliminate-bone-loss-influence-of-implant-neck-design-and-platform-switching
#3
Sergio Spinato, Pablo Galindo-Moreno, Fabio Bernardello, Davide Zaffe
PURPOSE: This retrospective study quantitatively analyzed the minimum prosthetic abutment height to eliminate bone loss after 4.7-mm-diameter implant placement in maxillary bone and how grafting techniques can affect the marginal bone loss in implants placed in maxillary areas. MATERIALS AND METHODS: Two different implant types with a similar neck design were singularly placed in two groups of patients: the test group, with platform-switched implants, and the control group, with conventional (non-platform-switched) implants...
August 17, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28817224/a-novel-post-hoc-method-for-detecting-index-switching-finds-no-evidence-for-increased-switching-on-the-illumina-hiseq-x
#4
Gregory L Owens, Marco Todesco, Emily B M Drummond, Sam Yeaman, Loren H Rieseberg
High throughput sequencing using the Illumina HiSeq platform is a pervasive and critical molecular ecology resource, and has provided the data underlying many recent advances. A recent study has suggested that 'index switching', where reads are misattributed to the wrong sample, may be higher in new versions of the HiSeq platform. This has the potential to invalidate both published and in-progress work across the field. Here, we test for evidence of index switching in an exemplar whole genome shotgun dataset sequenced on both the Illumina HiSeq 2500, which should not have the problem, and the Illumina HiSeq X, which may...
August 17, 2017: Molecular Ecology Resources
https://www.readbyqxmd.com/read/28817132/plasma-of-argon-cleaning-treatment-on-implant-abutments-in-periodontally-healthy-patients-six-years-postloading-results-of-a-randomized-controlled-trial
#5
Luigi Canullo, Marco Tallarico, Miguel Penarrocha, Giuseppe Corrente, Joseph Fiorellini, David Penarrocha
The aim of this randomized, match-paired, triple-blinded, controlled clinical trial was to assess the 6-year radiographic changes around customized platform-switched abutments placed according to the one abutment-one time concept, with and without plasma of argon cleaning treatment. A total of 20 periodontally healthy patients received one maxillary implant between the premolars. Immediately before stage 2 surgery and abutment connection, patients were randomly assigned to the control (cleaning protocol by steam) or test group (plasma of argon treatment)...
September 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28805284/interaction-of-the-n-terminal-tandem-domains-of-hnrnp-ll-with-the-bcl2-promoter-i-motif-dna-sequence
#6
Harald Schwalbe, Lauris Lannes, Phoebe Young, Christian Richter, Nina Morgner
The human genome contains GC-rich sequences able to form tetraplex secondary structures known as G-quadruplex and i-motif. Such sequences are notably present in the promoter region of oncogenes and are proposed to function as regulatory elements of the gene expression. The P1 promoter of BCL2 contains a 39-mer C-rich sequence (Py39wt) which can fold into a hairpin or an i-motif in a pH-dependent manner in vitro. The protein hnRNP LL was identified to recognise the i-motif over the hairpin conformation and act as an activating transcription factor...
August 14, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28805061/a-triple-helix-molecular-switch-electrochemical-ratiometric-biosensor-for-ultrasensitive-detection-of-nucleic-acids
#7
Erhu Xiong, Zhenzhen Li, Xiaohua Zhang, Jiawan Zhou, Xiaoxia Yan, Yunqing Liu, Jinhua Chen
Biomolecular receptors such as nucleic acids that switch between two or more conformations upon binding to a specific target can be used to build specific and sensitive biosensors. In this work, based on the electrochemical dual-signaling ratiometric strategy and triple-helix molecular switch, we developed a selective, reusable, and simple electrochemical DNA (E-DNA) biosensor for target DNA (T-DNA) detection. A hairpin DNA capture probe labeled with methylene blue (MB-DNA) self-assembles on the surface of gold electrode (GE) through Au-S bond, and then a single-strand DNA modified with two ferrocenes (Fc-DNA) on each end to enhance the oxidation signal hybridizes with the MB-DNA to form a triple-helix conformation...
August 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28800964/the-effect-of-metal-ions-released-from-different-dental-implant-abutment-couples-on-osteoblast-function-and-secretion-of-bone-resorbing-mediators
#8
Ghada O Alrabeah, Peter Brett, Jonathan C Knowles, Haralampos Petridis
OBJECTIVES: The etiology of the reduced marginal bone loss observed around platform-switched implant-abutment connections is not clear but could be related to the release of variable amounts of corrosion products. The present study evaluated the effect of different concentrations of metal ions released from different implant abutment couples on osteoblastic cell viability, apoptosis and expression of genes related to bone resorption. METHODS: Osteoblastic cells were exposed to five conditions of culture media prepared containing metal ions (titanium, aluminum, vanadium, cobalt, chromium and molybdenum) in different concentrations representing the amounts released from platform-matched and platform-switched implant-abutment couples as a result of an earlier accelerated corrosion experiment...
August 4, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28800508/a-suspending-droplet-mode-paper-based-microfluidic-platform-for-low-cost-rapid-and-convenient-detection-of-lead-ii-ions-in-liquid-solution
#9
Han Sun, Wanbo Li, Zhen-Zhen Dong, Chong Hu, Chung-Hang Leung, Dik-Lung Ma, Kangning Ren
A paper-based microfluidic device based on unconventional principle was developed and used to detect lead ions through a two-step process including heated incubation and subsequent mixing. The device was made by generating a superhydrophobic pattern, which defines channel and reservoir barriers, on a water-impermeable paper substrate, followed by loading and drying the reagents in the defined reservoirs. Different from the conventional paper-based devices that are made of water-permeable paper, the as-prepared device holds water drops in discrete reservoirs, and the water drops will not move unless the device is titled along the direction of the predefined channels...
August 1, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28800131/atg2a-b-deficiency-switches-cytoprotective-autophagy-to-non-canonical-caspase-8-activation-and-apoptosis
#10
Zhenyuan Tang, Yoshinori Takahashi, Chong Chen, Ying Liu, Haiyan He, Nikolaos Tsotakos, Jacob M Serfass, Melat T Gebru, Han Chen, Megan M Young, Hong-Gang Wang
Autophagosomal membranes are emerging as platforms for various cell survival and death signaling networks beyond autophagy. While autophagy-dependent cell death has been reported in response to a variety of stimuli, the underlying molecular mechanisms remain far from clear. Here, we demonstrate that inhibition of autophagosome completion by Atg2A/B deletion accumulates immature autophagosomal membranes that promote non-canonical caspase-8 activation in response to nutrient starvation via an intracellular death-inducing signaling complex (iDISC)...
August 11, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28791863/an-improved-aromatic-substitution-rearrangement-based-ratiometric-fluorescent-cysteine-specific-probe-and-its-application-of-real-time-imaging-under-oxidative-stress-in-living-zebrafish
#11
Longwei He, Xueling Yang, Kaixin Xu, Weiying Lin
Biothiols, including cysteine (Cys), homocysteine (Hcy) and glutathione (GSH), play a crucial role in many physiological processes. Cys production and metabolism is closely connected with Hcy and GSH, meanwhile, the dynamic antioxidant defenses network by Cys is independent on GSH system, and Cys can serve as a more effective biomarker of oxidative stress. Hence, it is significantly and urgently to develop an efficient method for specific detection of Cys over other biothiols (Hcy/GSH). However, most of present Cys-specific fluorescent probes distinguished Cys from Hcy through response time, which would be suffered to an unavoidable interference from Hcy in long time detection...
August 9, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28782354/a-novel-ternary-electrochemiluminescence-system-based-on-rubrene-microrods-as-luminophore-and-pt-nanomaterials-as-coreaction-accelerator-for-ultrasensitive-detection-of-microrna-from-cancer-cells
#12
Jia-Li Liu, Zhi-Ling Tang, Ying Zhuo, Yaqin Chai, Ruo Yuan
As the only endogenous co-reactant in ECL system, the dissolved O2 was the ideal candidate due to the mild reaction and easy operation, but compared to S2O82-, the dissolved O2 with weaker redox activity suffers from the poor enhancement effect of luminophore, which restricted the further application in bioanalysis. Here, a high-intense ECL signal was gained by the employing of Pt nanomaterials as co-reaction accelerator to generate more intermediate of dissolved O2 to promote the co-reaction efficiency. Based on a new ternary ECL system of Pt nanomaterials as the co-reaction accelerator, dissolved O2 as co-reactant, and a neotype rubrene microrods as luminophore, an efficient "on-off-on" solid-state ECL switch platfrom was designed for ultrasensitive microRNA (miRNA) detection with a background reduction strategy of ferrocene-labeled single-stranded DNA (Fc-DNA) as a quencher...
August 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28782245/development-of-a-novel-robotic-platform-with-controllable-stiffness-manipulation-arms-for-laparoendoscopic-single-site-surgery-less
#13
Jianchen Wang, Shuxin Wang, Jinhua Li, Xiangyun Ren, Randall Miller Briggs
BACKGROUND: For current LESS robotic systems, the trade-off between dexterity and payload capability is always present. This paper presents a novel LESS robotic platform equipped with controllable stiffness manipulation arms. METHODS: Each manipulation arm with an articulated section and a controllable stiffness continuum section (CSCS) can be switched between a 7-DoF compliant status and 5-DoF rigid status according to the operation requirement. Screw theory and product exponential formula are used to quantify the kinematic performance...
August 6, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28782061/ubiquitous-accessibility-for-people-with-visual-impairments-are-we-there-yet
#14
Syed Masum Billah, Vikas Ashok, Donald E Porter, I V Ramakrishnan
Ubiquitous access is an increasingly common vision of computing, wherein users can interact with any computing device or service from anywhere, at any time. In the era of personal computing, users with visual impairments required special-purpose, assistive technologies, such as screen readers, to interact with computers. This paper investigates whether technologies like screen readers have kept pace with, or have created a barrier to, the trend toward ubiquitous access, with a specific focus on desktop computing as this is still the primary way computers are used in education and employment...
May 2017: Proceedings of the SIGCHI Conference on Human Factors in Computing Systems
https://www.readbyqxmd.com/read/28782032/a-photonic-platform-for-donor-spin-qubits-in-silicon
#15
Kevin J Morse, Rohan J S Abraham, Adam DeAbreu, Camille Bowness, Timothy S Richards, Helge Riemann, Nikolay V Abrosimov, Peter Becker, Hans-Joachim Pohl, Michael L W Thewalt, Stephanie Simmons
Donor spins in silicon are highly competitive qubits for upcoming quantum technologies, offering complementary metal-oxide semiconductor compatibility, coherence (T2) times of minutes to hours, and simultaneous initialization, manipulation, and readout fidelities near ~99.9%. This allows for many quantum error correction protocols, which will be essential for scale-up. However, a proven method of reliably coupling spatially separated donor qubits has yet to be identified. We present a scalable silicon-based platform using the unique optical properties of "deep" chalcogen donors...
July 2017: Science Advances
https://www.readbyqxmd.com/read/28780384/influences-of-microgap-and-micromotion-of-implant-abutment-interface-on-marginal-bone-loss-around-implant-neck
#16
REVIEW
Yang Liu, Jiawei Wang
OBJECTIVE: To review the influences and clinical implications of micro-gap and micro-motion of implant-abutment interface on marginal bone loss around the neck of implant. DESIGN: Literatures were searched based on the following Keywords: implant-abutment interface/implant-abutment connection/implant-abutment conjunction, microgap, micromotion/micromovement, microleakage, and current control methods available. The papers were then screened through titles, abstracts, and full texts...
July 29, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28771307/co-registered-in-situ-secondary-electron-and-mass-spectral-imaging-on-the-helium-ion-microscope-demonstrated-using-lithium-titanate-and-magnesium-oxide-nanoparticles
#17
David Dowsett, Tom Wirtz
The development of a high resolution elemental imaging platform combining co-registered secondary ion mass spectrometry and high resolution secondary electron imaging is reported. The basic instrument setup and operation are discussed and in-situ image correlation is demonstrated on a lithium titanate and magnesium oxide nanoparticle mixture. The instrument uses both helium and neon ion beams generated by a gas field ion source to irradiate the sample. Both secondary electrons and secondary ions may be detected...
August 3, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28769057/enhancing-modulation-of-thermal-conduction-in-vanadium-dioxide-thin-film-by-nanostructured-nanogaps
#18
Hwan Sung Choe, Joonki Suh, Changhyun Ko, Kaichen Dong, Sangwook Lee, Joonsuk Park, Yeonbae Lee, Kevin Wang, Junqiao Wu
Efficient thermal management at the nanoscale is important for reducing energy consumption and dissipation in electronic devices, lab-on-a-chip platforms and energy harvest/conversion systems. For many of these applications, it is much desired to have a solid-state structure that reversibly switches thermal conduction with high ON/OFF ratios and at high speed. Here we describe design and implementation of a novel, all-solid-state thermal switching device by nanostructured phase transformation, i.e., modulation of contact pressure and area between two poly-silicon surfaces activated by microstructural change of a vanadium dioxide (VO2) thin film...
August 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28753331/bright-exciton-fine-structure-splittings-in-single-perovskite-nanocrystals
#19
Chunyang Yin, Liyang Chen, Nan Song, Yan Lv, Fengrui Hu, Chun Sun, William W Yu, Chunfeng Zhang, Xiaoyong Wang, Yu Zhang, Min Xiao
Here we show that, in single perovskite CsPbI_{3} nanocrystals synthesized from a colloidal approach, a bright-exciton fine-structure splitting as large as hundreds of μeV can be resolved with two orthogonally and linearly polarized photoluminescence peaks. This doublet could switch to a single peak when a single CsPbI_{3} nanocrystal is photocharged to eliminate the electron-hole exchange interaction. The above findings have prepared an efficient platform suitable for probing exciton and spin dynamics of semiconductor nanostructures at the visible-wavelength range, from which a variety of practical applications such as in entangled photon-pair source and quantum information processing can be envisioned...
July 14, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28746392/design-characterization-and-experimental-validation-of-a-compact-flexible-pulsed-power-architecture-for-ex-vivo-platelet-activation
#20
Allen L Garner, Antonio Caiafa, Yan Jiang, Steve Klopman, Christine Morton, Andrew S Torres, Amanda M Loveless, V Bogdan Neculaes
Electric pulses can induce various changes in cell dynamics and properties depending upon pulse parameters; however, pulsed power generators for in vitro and ex vivo applications may have little to no flexibility in changing the pulse duration, rise- and fall-times, or pulse shape. We outline a compact pulsed power architecture that operates from hundreds of nanoseconds (with the potential for modification to tens of nanoseconds) to tens of microseconds by modifying a Marx topology via controlling switch sequences and voltages into each capacitor stage...
2017: PloS One
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