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Platform switching

Yasunori Hotta, Koji Ito, Shinichi Komatsu, Takashi Saito
A single-tooth implant restoration is generally performed for maxillary single-first-molar replacement. If the interdental space between the second premolar and the second molar is large enough, a double-implant placement can be performed to avoid creating mesiodistal cantilever and to distribute occlusal loading forces.If there is not adequate space for a double-implant placement to be performed mesiodistally along the crest of the alveolar ridge line, they should be placed along a diagonal line offset lingually to increase the space...
December 2015: Int J Implant Dent
Mohammad D Al Amri, Sulieman S Al-Johany, Abdulaziz M Al Baker, Mohammad Q Al Rifaiy, Tariq S Abduljabbar, Abdulaziz A Al-Kheraif
OBJECTIVE: The aim of the present 36-month prospective split-mouth clinical trial was to investigate the peri-implant soft tissue changes and crestal bone loss (CBL) around delayed loaded platform-switched implants placed at crestal and subcrestal levels. MATERIAL AND METHODS: Twenty-three individuals with bilaterally missing either mandibular first or second molars were included. The test and control sites were defined as follows: (i) test sites: implants placed 2 mm below the alveolar crest (subcrestal); (ii) control sites: implants placed at bone level (crestal)...
October 14, 2016: Clinical Oral Implants Research
Li Qiu, Yang Shi, Jianfei Pan, Bo Zhang, Gang Xu
This paper investigates the collaborative tracking control for dual linear switched reluctance machines (LSRMs) over a communication network with random time delays. Considering the spatio-temporal constraint relationship of the dual LSRMs in complex industrial processes, the collaborative tracking control scheme is proposed based on the networked motion control method. The stability conditions and the controller design method for the networked dual LSRMs are obtained from the two motors relative position error by using Lyapunov theory and delay systems approach...
October 11, 2016: IEEE Transactions on Cybernetics
A Sipahigil, R E Evans, D D Sukachev, M J Burek, J Borregaard, M K Bhaskar, C T Nguyen, J L Pacheco, H A Atikian, C Meuwly, R M Camacho, F Jelezko, E Bielejec, H Park, M Lončar, M D Lukin
Efficient interfaces between photons and quantum emitters form the basis for quantum networks and enable optical nonlinearities at the single-photon level. We demonstrate an integrated platform for scalable quantum nanophotonics based on silicon-vacancy (SiV) color centers coupled to diamond nanodevices. By placing SiV centers inside diamond photonic crystal cavities, we realize a quantum-optical switch controlled by a single color center. We control the switch using SiV metastable states and observe optical switching at the single-photon level...
October 13, 2016: Science
Pinghua Ling, Jianping Lei, Huangxian Ju
In this work, we designed a nanoscaled porphyrinic metal-organic framework (PorMOF) with iron porphyrin as linker and zirconium ion as node for electrochemical detection of telomerase activity. The as-prepared PorMOF was characterized with scanning electron microscopy, powder X-ray diffraction and spectroscopic techniques, and demonstrated the excellent electrocatalytic activity towards O2 reduction. Sequentially, the functionalization of PorMOF with streptavidin results in water-stable electrochemical tracer for detection of telomerase...
October 11, 2016: Analytical Chemistry
L E Korthauer, N T Nowak, M Frahmand, I Driscoll
Although effective spatial navigation requires memory for objects and locations, navigating a novel environment may also require considerable executive resources. The present study investigated associations between performance on the virtual Morris Water Task (vMWT), an analog version of a nonhuman spatial navigation task, and neuropsychological tests of executive functioning and spatial performance in 75 healthy young adults. More effective vMWT performance (e.g., lower latency and distance to reach hidden platform, greater distance in goal quadrant on a probe trial, fewer path intersections) was associated with better verbal fluency, set switching, response inhibition, and ability to mentally rotate objects...
October 5, 2016: Behavioural Brain Research
Simon J Hazenberg, Rob van Lier
In three experiments, we investigated the influence of object-specific sounds on haptic scene recognition without vision. Blindfolded participants had to recognize, through touch, spatial scenes comprising six objects that were placed on a round platform. Critically, in half of the trials, object-specific sounds were played when objects were touched (bimodal condition), while sounds were turned off in the other half of the trials (unimodal condition). After first exploring the scene, two objects were swapped and the task was to report, which of the objects swapped positions...
July 2016: I-Perception
A Colin, L Bonnemay, C Gayrard, J Gautier, Z Gueroui
The spatiotemporal organization of proteins within cells is essential for cell fate behavior. Although it is known that the cytoskeleton is vital for numerous cellular functions, it remains unclear how cytoskeletal activity can shape and control signaling pathways in space and time throughout the cell cytoplasm. Here we show that F-actin self-organization can trigger signaling pathways by engineering two novel properties of the microfilament self-organization: (1) the confinement of signaling proteins and (2) their scaffolding along actin polymers...
October 4, 2016: Scientific Reports
Woo-Hyun Cho, Jung-Soo Han
Flexibility in using different learning strategies was assessed in two different inbred strains of mice, the C57BL/6 and DBA/2 strains. Mice were trained sequentially in two different Morris water maze protocols that tested their ability to switch their learning strategy to complete a new task after first being trained in a different task. Training consisted either of visible platform trials (cued training) followed by subsequent hidden platform trials (place training) or the reverse sequence (place training followed by cued training)...
2016: Frontiers in Behavioral Neuroscience
M Cassetta, A Driver, G Brandetti, S Calasso
The aim of this study was to measure the crestal bone level changes at 60 months of follow-up and to evaluate the influence of biologically relevant, anatomical, and implant-related variables. A prospective study design was used. STROBE guidelines were followed. A total of 576 implants were inserted in 270 patients needing an implant-supported, partial, fixed dental prosthesis or a single crown. Standardized peri-apical radiographs were obtained at 2 months (time of implant-abutment connection and prosthetic loading) and 60 months of follow-up...
September 28, 2016: International Journal of Oral and Maxillofacial Surgery
Dan Long, Tianlong Liu, Longfei Tan, Haitang Shi, Ping Liang, Shunsong Tang, Qiong Wu, Jie Yu, Jianping Dou, Xianwei Meng
Microwave (MW) therapy, as a promising type of thermal therapy, has been attracting more and more attention from scientists. The combination of thermal and chemotherapy is of great significance in the latest studies of synergistic tumor therapy. However, the research on the MW therapy mechanism, especially the nonthermal effect applied in the combined cancer therapy, is not thorough enough. Pleasantly, we have discovered that nonthermal MW irradiation can promote the cellular uptake of nanoparticles and anticancer drugs via experiments in vitro and in vivo...
October 5, 2016: ACS Nano
Jianqiong Yang, Haiqing Liu, Linfu Li, Hai Liu, Weimei Shi, Xiaoliang Yuan, Longhuo Wu
IRE1 signaling is the most evolutionarily conserved branch in the UPR. IRE1 is an ER stress sensor and provides a structure-based platform for the unfolded proteins docking, which causes the luminal domain conformational change and oligomerization. This self-association of IRE1 facilitates the phosphorylation of activation loop, which unlocks the auto-inhibition in the kinase domain. The activating mechanistic cascade is thus initiated to induce DFG-in conformational change and movement of αC-helix to the active site...
September 27, 2016: Current Medicinal Chemistry
Rodolfo B Anchieta, Lucas S Machado, Ronaldo Hirata, Paulo G Coelho, Estevam A Bonfante
This study evaluated the probability of survival (reliability) of platform-switched fixed dental prostheses (FDPs) cemented on different implant-abutment connection designs. Eighty-four-three-unit FDPs (molar pontic) were cemented on abutments connected to two implants of external or internal hexagon connection. Four groups (n = 21 each) were established: external hexagon connection and regular platform (ERC); external hexagon connection and switched platform (ESC); internal hexagon and regular platform (IRC); and internal hexagon and switched platform (ISC)...
October 2016: European Journal of Oral Sciences
Sheng Lin, Lihua Lu, Tian-Shu Kang, Jean-Louis Mergny, Chung-Hang Leung, Dik-Lung Ma
Sialic acid (Sia) binding immunoglobulin (Ig)-like lectin-5 (Siglec-5) is a type-I transmembrane protein, and it has been demonstrated as a biomarker of granulocytic maturation and acute myeloid leukemia phenotype. Herein we aimed to construct a method that could sensitively detect Siglec-5 by taking advantage of the high affinity and selectivity of the K19 aptamer for its cognate target, and the selective interaction of luminescent iridium(III) transition metal complexes with G-quadruplex DNA. The iridium(III) complex 1 [Ir(tpyd)2(2,9-dmphen)]PF6 (where tpyd =2-(m-tolyl)pyridine; 2,9-dmphen =2,9-dimethyl-1,10-phenanthroline) was synthesized, and it displayed high luminescence for G-quadruplex DNA compared to dsDNA and ssDNA...
October 6, 2016: Analytical Chemistry
Hena Khalique, Jorge López Marco, Filip Lim
BACKGROUND: Although Herpes Simplex Virus Type 1 (HSV-1) has outstanding properties for gene delivery vectors and its genome is available in bacterial artificial chromosomes (BACs) for mutagenesis studies, one impediment is the presence of about 15.4 kilobases of DNA sequences which are duplicated in the HSV-1 genome, complicating vector construction and stability. METHODS: As a useful platform for building HSV-1 vectors, we have constructed a fully haploid HSV-1 genome BAC by deletion of one of these repeats, confirming that viral propagation in culture is not impaired...
September 27, 2016: Journal of Gene Medicine
Michele Felletti, Julia Stifel, Lena A Wurmthaler, Sophie Geiger, Jörg S Hartig
The utilization of ribozyme-based synthetic switches in biotechnology has many advantages such as an increased robustness due to in cis regulation, small coding space and a high degree of modularity. The report of small endonucleolytic twister ribozymes provides new opportunities for the development of advanced tools for engineering synthetic genetic switches. Here we show that the twister ribozyme is distinguished as an outstandingly flexible expression platform, which in conjugation with three different aptamer domains, enables the construction of many different one- and two-input regulators of gene expression in both bacteria and yeast...
2016: Nature Communications
Ehtisham Mahmud, Florian Schmid, Peter Kalmar, Hannes Deutschmann, Franz Hafner, Peter Rief, Marianne Brodmann
OBJECTIVES: The goal of this study was to evaluate the feasibility and safety of a robotic-assisted platform (CorPath 200, Corindus Vascular Robotics, Waltham, Massachusetts) for treating peripheral artery disease. BACKGROUND: A robotic-assisted platform for percutaneous coronary intervention is available for treating coronary artery disease. METHODS: In this prospective single-arm trial, patients with symptomatic peripheral artery disease (Rutherford class 2 to 5) affecting the femoropoplital artery were enrolled...
October 10, 2016: JACC. Cardiovascular Interventions
José Vázquez-Prado, Ismael Bracho-Valdés, Rodolfo Daniel Cervantes-Villagrana, Guadalupe Reyes-Cruz
Cancer cells and stroma cells in tumors secrete chemotactic agonists that exacerbate invasive behavior, promote tumor-induced angiogenesis, and recruit protumoral bone marrow-derived cells. In response to shallow gradients of chemotactic stimuli recognized by G protein-coupled receptors (GPCRs), Gβγ-dependent signaling cascades contribute to specifying the spatiotemporal assembly of cytoskeletal structures that can dynamically alter cell morphology. This sophisticated process is intrinsically linked to the activation of Rho GTPases and their cytoskeletal-remodeling effectors...
November 2016: Molecular Pharmacology
Michele Cassetta, Alfonso Di Mambro, Matteo Giansanti, Giulia Brandetti
PURPOSE: The aim of this prospective clinical study was to evaluate the survival up to 5 years of Morse cone-connection implants with platform switch considering the influence of biologically relevant, anatomical, and stress-related variables. STROBE guidelines were followed. MATERIALS AND METHODS: Seven hundred forty-eight implants were inserted in 350 patients. Follow-up visits were scheduled at the time of stagetwo surgery (2 months later) and at 6, 12, 24, 36, and 60 months...
September 2016: International Journal of Oral & Maxillofacial Implants
Frank Lüdicke, Gizelle Baker, John Magnette, Patrick Picavet, Rolf Weitkunat
INTRODUCTION: Heating rather than burning tobacco reduces levels of harmful and potentially harmful constituents, and consumer products using this approach aim to reduce exposure to tobacco toxicants. The Tobacco Heating System (THS) version 2.1 has been enhanced from earlier prototypes with an improved heat control and sensorial experience and thereby user acceptance. Exposure measurements are required to determine whether it may be possible to reduce the individual health risk compared to smoking combustible cigarettes (CCs)...
July 1, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
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