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https://www.readbyqxmd.com/read/28730494/deconstructing-the-metabolic-networks-of-oncogenic-signaling-using-targeted-liquid-chromatography-tandem-mass-spectrometry-lc-ms-ms
#1
George Poulogiannis
Metabolic reprogramming is recognized as an emerging hallmark of oncogenic signaling and cancer development. Hence the need to identify novel quantitative analytical platforms for studying metabolism in vitro and in vivo has dramatically increased. Here, we describe the experimental workflow for a targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) approach involving positive/negative ion switching to analyze >250 metabolites of central carbon metabolism, nucleotides, and amino acids.
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28728166/whole-genome-sequencing-revealed-novel-prognostic-biomarkers-and-promising-targets-for-therapy-of-ovarian-clear-cell-carcinoma
#2
Hiroaki Itamochi, Tetsuro Oishi, Nao Oumi, Satoshi Takeuchi, Kosuke Yoshihara, Mikio Mikami, Nobuo Yaegashi, Yasuhisa Terao, Kazuhiro Takehara, Kimio Ushijima, Hidemichi Watari, Daisuke Aoki, Tadashi Kimura, Toshiaki Nakamura, Yoshihito Yokoyama, Junzo Kigawa, Toru Sugiyama
BACKGROUND: Ovarian clear cell carcinoma (OCCC) is mostly resistant to standard chemotherapy that results in poor patient survival. To understand the genetic background of these tumours, we performed whole-genome sequencing of OCCC tumours. METHODS: Tumour tissue samples and matched blood samples were obtained from 55 Japanese women diagnosed with OCCC. Whole-genome sequencing was performed using the Illumina HiSeq platform according to standard protocols. RESULTS: Alterations to the switch/sucrose non-fermentable (SWI/SNF) subunit, the phosphatidylinositol-3-kinase (PI3K)/Akt signalling pathway, and the receptor tyrosine kinase (RTK)/Ras signalling pathway were found in 51%, 42%, and 29% of OCCC tumours, respectively...
July 20, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28727471/cutting-edge-implant-rehabilitation-design-and-management-a-tapered-abutment-approach
#3
Mark Bishara, Gregori M Kurtzman
Immediate implant placement can pose challenges surgically and, ultimately, restoratively. Yet immediate placement has become the standard when adequate bone is present to achieve primary stability and site infection is minimal. To avoid prosthetic complications and ensure the implant is encased in bone after healing, proper planning must consider that implant placement does not necessarily need to follow the trajectory of the root socket. As discussed in this article, maxillary anterior sites have potential issues related to the "triangle of bone" that are not encountered in molar sites and demand different approaches to ensure treatment success...
July 2017: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/28727461/risk-indicators-and-prevention-of-implant-soft-tissue-complications-interproximal-papillae-loss-and-midfacial-implant-mucosal-recessions
#4
James Mailoa, Richard J Miron, Hom-Lay Wang
Achieving a long-term esthetic implant restoration in the maxillary anterior area is sometimes unpredictable. This article reviews several risk indicators of implant mucosal recession and loss of interproximal papillae, and how to prevent these risks. Results obtained from the literature suggest that the following factors are strongly related to implant soft-tissue complications: buccally positioned implant placement, a thin gingival biotype, lack of an adequate amount of keratinized mucosa, implant placement after ridge augmentation procedures, an increased distance of tooth bone peak to the contact point, and an inadequate horizontal implant-tooth distance...
July 2017: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/28726386/a-smart-biointerface-with-photoswitched-functions-between-bactericidal-activity-and-bacteria-releasing-ability
#5
Ting Wei, Wenjun Zhan, Qian Yu, Hong Chen
Smart biointerfaces with capability to regulate cell-surface interactions in response to external stimuli are of great interest for both fundamental research and practical applications. Smart surfaces with "ON/OFF" switchability for a single function such as cell attachment/detachment are well-known and useful, but the ability to switch between two different functions may be seen as the next level of "smart". In this work reported, a smart supramolecular surface capable of switching functions reversibly between bactericidal activity and bacteria-releasing ability in response to UV-visible light is developed...
July 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28725452/mapmysmoke-feasibility-of-a-new-quit-cigarette-smoking-mobile-phone-application-using-integrated-geo-positioning-technology-and-motivational-messaging-within-a-primary-care-setting
#6
Robert S Schick, Thomas W Kelsey, John Marston, Kay Samson, Gerald W Humphris
BACKGROUND: Approximately 11,000 people die in Scotland each year as a result of smoking-related causes. Quitting smoking is relatively easy; maintaining a quit attempt is a very difficult task with success rates for unaided quit attempts stubbornly remaining in the single digits. Pharmaceutical treatment can improve these rates by lowering the overall reward factor of nicotine. However, these and related nicotine replacement therapies do not operate on, or address, the spatial and contextual aspects of smoking behaviour...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28723196/label-free-homogeneous-electroanalytical-platform-for-pesticide-detection-based-on-acetylcholinesterase-mediated-dna-conformational-switch-integrated-with-rolling-circle-amplification
#7
Xiaojuan Liu, Mengmeng Song, Ting Hou, Feng Li
This study addresses the need for sensitive pesticide assay by reporting a new label-free and immobilization-free homogeneous electroanalytical strategy, which combines acetylcholinesterase (AChE)-catalyzed hydrolysis product-mediated DNA conformational switch and rolling circle amplification (RCA) to detect organophosphorous and carbamate pesticides in a "signal-on" mode. When target pesticides were present, AChE activity was inhibited and could not trigger the following DNA conformational change and the RCA reaction, which results in numerous methylene blue (MB) molecules in a free state, generating a strong electrochemical response...
April 28, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28708924/bone-and-soft-tissue-response-in-bone-level-implants-restored-with-platform-switching-a-5-year-clinical-prospective-study
#8
Laura Lago, Luis da Silva, Francisco Gude, Benito Rilo
PURPOSE: The aim of this prospective study was to evaluate radiographic levels of peri-implant bone crest as well as soft tissue response, papilla height, and buccal mucosa recession, in bone-level implants restored with platform switching after 1-year and 5-year follow-ups. MATERIALS AND METHODS: This prospective study called for the placement of 59 implants to obtain a target of 90% power. To compensate for possible dropouts, the sample size was adjusted to 67 implants...
July 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28708038/influence-of-implant-neck-surface-and-placement-depth-on-crestal-bone-changes-around-platform-switched-implants-a-clinical-and-radiographic-study-in-dogs
#9
Cristina Valles, Xavier Rodríguez-Ciurana, Jose Nart, Antonio Santos, Marta Galofre, Dennis Tarnow
OBJECTIVES: The aim of this animal study was to analyze bone remodeling around platform-switching (PS) implants with and without a machined collar placed at different levels in relation to crestal bone in a canine model. MATERIAL AND METHODS: All mandibular premolars and the first molars were extracted in five dogs. At 6 months, six PS implants with and without a machined neck (MACH and GBAE implants, respectively) were randomly inserted in each hemimandible positioning the implant-abutment interface in either a supracrestal (+1...
July 14, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28697440/electrochemical-nucleic-acid-detection-based-on-parallel-structural-dsdna-recombinant-azurin-hybrid
#10
Mohsen Mohammadniaei, Taek Lee, Jinho Yoon, Donghyun Lee, Jeong-Woo Choi
Several challenges remained to fabricate a molecular-level nucleic acid biosensor such as surface immobilization control, single mismatch detection and low current response. To overcome those issues, for the first time, authors presented a novel parallel structural dsDNA/recombinant azurin (PSD/rAzu) hybrid structure for the general nucleic acid detection. The PSD was designed and introduced by the optimized 8 Ag(+) ions to have greater conductivity than the canonical dsDNA, and conjugated with rAzu to develop a general platform for electrochemical detection of miRNAs and viral DNAs with high reproducibility and ultra-sensitivity towards single base pair mutation...
July 5, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28696342/single-inxga1-xas-nanowire-p-si-heterojunction-based-nano-rectifier-diode
#11
Krishnendu Sarkar, Mainak Palit, Shrabani Guhathakurata, Sanatan Chattopadhyay, Pallab Banerji
Nanoscale power supply units will be indispensable for fabricating next generation smart nanoelectronic integrated circuit. Fabrication of nanoscale rectifier circuits on Si platform is required for integrating nanoelectronic devices with on-chip power supply units. In the present study, a nanorectifier diode based on a single standalone InxGa1-xAs nanowire/p-Si (111) heterojunction fabricated by metal organic chemical vapor deposition technique has been studied. The nanoheterojunction diodes have shown good rectification and fast switching characteristics...
July 11, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28696337/memristive-device-based-learning-for-navigation-in-robots
#12
Mohammad Sarim, Manish Kumar, Rashmi Jha, Ali A Minai
Biomimetic robots have gained attention recently for various applications ranging from resource hunting to search and rescue operations during disasters. Biological species are known to intuitively learn from the environment, gather and process data, and make appropriate decisions. Such sophisticated computing capabilities in robots are difficult to achieve, especially if done in real-time with ultra- low energy consumption. Here, we present a novel memristive device based learning architecture for robots. Two terminal memristive devices with resistive switching of oxide layer are modeled in a crossbar array to develop a neuromorphic platform that can impart active real-time learning capabilities in a robot...
July 11, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/28690179/polydopamine-immobilized-polypropylene-microfuge-tube-as-a-ph-responsive-platform-for-capture-release-of-dna-from-foodborne-pathogens
#13
Zitao Zhong, Xin Yao, Xiaomei Gao, Li Jia
A rapid, convenient and efficient DNA extraction method with no need for toxic agents and centrifugation was reported. A polypropylene microfuge (MF) tube was used as the substrate to immobilize polydopamine (PDA). The prepared PDA-coated MF (PDA@MF) tube was used as a pH-responsive platform for rapid extraction of DNA based on pH-induced charge switch of amino and phenolic hydroxyl groups in PDA coating. The extraction procedure is simple and can be finished in 25 min. The PDA@MF tube was applied for extraction of genomic DNA from foodborne pathogens in milk...
July 6, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28671833/chip-based-all-optical-control-of-single-molecules-coherently-coupled-to-a-nanoguide
#14
Pierre Türschmann, Nir Rotenberg, Jan Renger, Irina Harder, Olga Lohse, Tobias Utikal, Stephan Götzinger, Vahid Sandoghdar
The feasibility of many proposals in nanoquantum-optics depends on the efficient coupling of photons to individual quantum emitters, the possibility to control this interaction on demand, and the scalability of the experimental platform. To address these issues, we report on chip-based systems made of one-dimensional subwavelength dielectric waveguides (nanoguides) and polycyclic aromatic hydrocarbon molecules. We discuss the design and fabrication requirements, present data on extinction spectroscopy of single molecules coupled to a nanoguide mode, and show how an external optical beam can switch the propagation of light via a nonlinear optical process...
July 10, 2017: Nano Letters
https://www.readbyqxmd.com/read/28669429/hybrid-photoacoustic-ultrasound-tomograph-for-real-time-finger-imaging
#15
Milan Oeri, Wolfgang Bost, Nicolas Sénégond, Steffen Tretbar, Marc Fournelle
We report a target-enclosing, hybrid tomograph with a total of 768 elements based on capacitive micromachined ultrasound transducer technology and providing fast, high-resolution 2-D/3-D photoacoustic and ultrasound tomography tailored to finger imaging. A freely programmable ultrasound beamforming platform sampling data at 80 MHz was developed to realize plane wave transmission under multiple angles. A multiplexing unit enables the connection and control of a large number of elements. Fast image reconstruction is provided by GPU processing...
June 29, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28667899/sensitivity-to-antitubulin-chemotherapeutics-is-potentiated-by-a-photoactivable-nanoliposome
#16
Xiaobing Wang, Xiufang Liu, Yixiang Li, Pan Wang, Xiaolan Feng, Quanhong Liu, Fei Yan, Hairong Zheng
Anti-microtubule therapy represents one of the most strategic cancer therapeutics. Tublin inhibitor such as paclitaxel (PTX) is well known to disturb the dynamic nature of microtubules, being considered as the first-line drug for various malignancies. However, PTX does not show favorable clinical outcomes due to serious systemic toxicities and low selectivity. The development of PTX delivery systems and combinational therapies has been conducted to enhance PTX efficacy with poorly defined mechanisms. Herein, we introduced a reactive oxygen species producible composite liposome based on a new photosensitizer sinoporphyrin sodium (DVDMS) to enhance the therapeutic effect of PTX through photochemical stimulation, and more importantly, the pivotal molecular regulation mechanisms were specifically explored...
June 23, 2017: Biomaterials
https://www.readbyqxmd.com/read/28664183/the-virtual-mouse-brain-a-computational-neuroinformatics-platform-to-study-whole-mouse-brain-dynamics
#17
Francesca Melozzi, Marmaduke M Woodman, Viktor K Jirsa, Christophe Bernard
Connectome-based modeling of large-scale brain network dynamics enables causal in silico interrogation of the brain's structure-function relationship, necessitating the close integration of diverse neuroinformatics fields. Here we extend the open-source simulation software The Virtual Brain (TVB) to whole mouse brain network modeling based on individual diffusion magnetic resonance imaging (dMRI)-based or tracer-based detailed mouse connectomes. We provide practical examples on how to use The Virtual Mouse Brain (TVMB) to simulate brain activity, such as seizure propagation and the switching behavior of the resting state dynamics in health and disease...
May 2017: ENeuro
https://www.readbyqxmd.com/read/28660339/a-multifunctional-fluorescent-aptamer-probe-for-highly-sensitive-and-selective-detection-of-cadmium-ii
#18
Yu-Feng Zhu, Yong-Sheng Wang, Bin Zhou, Jun-Hui Yu, Li-Lan Peng, Yan-Qin Huang, Xue-Jiao Li, Si-Han Chen, Xian Tang, Xiao-Feng Wang
We report a highly sensitive and selective strategy for Cd(II) assay using a singly labeled multifunctional probe consisting of a Cd(II)-specific aptamer (CAP), which acted as a recognition element for Cd(II) and a signal reporter. The presence of Cd(II) can induce the conformational switching of the CAP, accompanied by a change in fluorescence intensity. Thereby, a fluorescence strategy for Cd(II) assay was established. The proposed method has a detection limit of 2.15 nM, which is much lower than the detection limits reported in related literature...
June 29, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28657165/serum-n-glycome-alterations-in-breast-cancer-during-multi-modal-treatment-and-follow-up
#19
Radka Saldova, Vilde D Haakensen, Einar Rødland, Ian Walsh, Henning Stöckmann, Olav Engebraaten, Anne-Lise Børresen-Dale, Pauline M Rudd
Using our recently developed high-throughput automated platform, N-glycans from all serum glycoproteins from breast cancer patients were analysed at diagnosis, after neoadjuvant chemotherapy, surgery, radiotherapy, and up to 3 years after surgery. Surprisingly, alterations in the serum N-glycome after chemotherapy were pro-inflammatory with an increase in glycan structures associated with cancer. Surgery, on the other hand, induced anti-inflammatory changes in the serum N-glycome, towards a non-cancerous phenotype...
June 28, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28654244/monolithically-integrated-flexible-black-phosphorus-complementary-inverter-circuits
#20
Yuanda Liu, Kah-Wee Ang
Two-dimensional (2D) inverter is a fundamental building block for flexible logic circuit which has previously been realized by heterogeneously wiring transistors with two discrete channel materials. Here, we demonstrate a monolithically integrated complementary inverter made using a homogenous black phosphorus (BP) nanosheet on flexible substrates. The digital logic inverter circuit is demonstrated via effective threshold voltage tuning within a single BP material, which offers both electron and hole dominated conducting channels with nearly symmetric pinch-off and current saturation...
June 27, 2017: ACS Nano
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