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Platform switching

Thomas Lepitre, Clement Denhez, Jan Moncol, Mohamed Othman, Ata Martin Lawson, Adam Daïch
Herein is reported two successive original routes leading to two novel families of polyheterocycles starting from the versatile chromone-based Michael acceptors platform. The major aspect of this work is the selective access to these frameworks by changing the course of the domino process involved in their formation. First, enaminochromanones were selectively accessed under uncommon kinetic control. In this study, we showed that the tuning of the selectivity toward the kinetic product could be achieved by key structural modifications of the different reaction partners involved in the domino process...
October 20, 2017: Journal of Organic Chemistry
Dong Mei Mei, Baodong Zhao, Hao Xu, Yanhui Wang
BACKGROUND: There is no data available on the long-term outcomes of a rooted, platform-switched, microthreaded implant with a sandblasted, large-grid, and acid-etched surface. PURPOSE: This prospective, longitudinal study evaluated the clinical and radiographic outcomes of rooted, platform-switched, microthreaded and sandblasted, large-grid, and acid-etched (SLA) surface implants for 5 years. MATERIALS AND METHODS: Sixty implants were placed in sixty patients with partially edentulous maxillae or mandibles...
October 20, 2017: Clinical Implant Dentistry and related Research
Yu Heng Lau, Jack K Clegg, Jason R Price, Rene B Marquart, Matthew H Todd, Peter J Rutledge
Molecular switches have many potential applications in nanoscience and biomedicine. Transition metal complexes that can be switched from an unreactive state to an active one by a simple change in conditions (e.g. pH shift) or by binding to a specific biomolecular target - so-called target-activated metal complexes (TAMCs) - hold particular allure as a means of harnessing the potent but at times indiscriminate reactivity of metal-based drugs. We have prepared a series of ten structurally related ligands each of which bears a different pendant side-arm functional group off a common macrocyclic core...
October 19, 2017: Chemistry: a European Journal
Qing-Qing Wang, Ruoxi Dai, Chris Ying Cao, Hui Fang, Min Han, Quan-Li Li
OBJECTIVE: This review aims to compare peri-implant tissue changes in terms of clinical and radiographic aspects of implant restoration protocol using one-time abutment to repeated abutment connection in platform switched implant. METHOD: A structured search strategy was applied to three electronic databases, namely, Pubmed, Embase and Web of Science. Eight eligible studies, including seven randomised controlled studies and one controlled clinical study, were identified in accordance with inclusion/exclusion criteria...
2017: PloS One
Stefania Lettieri, Marta d'Amora, Adalberto Camisasca, Alberto Diaspro, Silvia Giordani
Multishell fullerenes, known as carbon nano-onions (CNOs), have emerged as a platform for bioimaging because of their cell-penetration properties and minimal systemic toxicity. Here, we describe the covalent functionalization of CNOs with a π-extended distyryl-substituted boron dipyrromethene (BODIPY) dye with on/off modulated fluorescence emission activated by an acidic environment. The switching properties are linked to the photoinduced electron transfer (PET) characteristics of the dimethylamino functionalities attached to the BODIPY core...
2017: Beilstein Journal of Nanotechnology
Colton McElheny, Daniel Hayes, Ram Devireddy
Three-dimensional (3D) bioprinting offers innovative research vectors for tissue engineering. However, commercially available bioprinting platforms can be cost prohibitive to small research facilities, especially in an academic setting. The goal is to design and fabricate a low-cost printing platform able to deliver cell-laden fluids with spatial accuracy along the X, Y, and Z axes of 0.1 mm. The bioprinter consists of three subassemblies: a base unit, a gantry, and a shuttle component. The platform utilizes four stepper motors to position along three axes and a fifth stepper motor actuating a pump...
December 2017: Journal of Medical Devices
Juan Flores, Carmen Álvarez-Novoa, Germán Barbieri, Conchita Martín, Mariano Sanz
AIM: To evaluate the long-term hard and soft tissue peri-implant tissue stability of bone level implants using a different implant placement protocol (submerged vs. transmucosal). MATERIALS AND METHODS: This study was partly a subset analysis of a multicentre study where in 40 patients a single bone level implant with platform switching and a conical implant-abutment interface was placed either submerged or transmucosal in non-molar sites. Changes in the peri-implant tissues between implant placement and 5 years were assessed clinically and radiologically...
October 15, 2017: Journal of Clinical Periodontology
E A Montano, J M Bush, A M Garver, M M Larijani, S M Wiechman, C H Baker, M R Wilson, R A Guerrieri, E A Benzinger, D N Gehres, M L Dickens
The application of massively parallel sequencing (MPS) is growing in the forensic DNA field, as forensic DNA laboratories are continuously seeking methods to gain information from a limited or degraded forensic sample. However, the laborious nature of current MPS methodologies required for successful library preparation and sequencing leave opportunities for improvement to make MPS a practical option for processing forensic casework. In this study, the Promega PowerSeq™ Auto/Y System Prototype, a MPS laboratory workflow that incorporates multiplex amplification, was selected for optimization with the objectives to introduce automation for relieving manual processing, and to reduce the number of steps recommended by the standard protocol...
October 5, 2017: Forensic Science International. Genetics
Gesmi Milcovich, Paolo Contessotto, Grazia Marsico, Siti Ismail, Abhay Pandit
Reactive oxygen species (ROS) are key pathological signals expressed in inflammatory diseases such as cancer, ischemic conditions and atherosclerosis. An ideal drug delivery system should not only be responsive to these signals but also should not elicit an unfavourable host response. This study presents an innovative platform for drug delivery where a natural/synthetic composite system composed of collagen type I and a synthesized polythioether, ensures a dual stimuli-responsive behaviour. Collagen type I is an extracellular matrix constituent protein, responsive to matrix metalloproteinases (MMP) cleavage per se...
October 13, 2017: Scientific Reports
Hilda Sucipto, Domen Pogorevc, Eva Luxenburger, Silke C Wenzel, Rolf Müller
Myxopyronins (MXN) and corallopyronins (COR) are structurally related α-pyrone antibiotics from myxobacteria that represent a highly promising compound class for the development of broad-spectrum antibacterial therapeutic agents. Their ability to inhibit RNA polymerase through interaction with the "switch region", a novel target, distant from previously characterized RNA polymerase inhibitors (e.g. rifampicin), makes them particularly promising candidates for further research. To improve compound supply for further investigation of MXN, COR and novel derivatives of these antibacterial agents, establishment of an efficient and versatile microbial production platform for myxobacterial α-pyrone antibiotics is highly desirable...
October 10, 2017: Metabolic Engineering
Martijn Fiers, Jorin Hoogenboom, Alice Brunazzi, Tom Wennekes, Gerco C Angenent, Richard G H Immink
BACKGROUND: Floral timing is a carefully regulated process, in which the plant determines the optimal moment to switch from the vegetative to reproductive phase. While there are numerous genes known that control flowering time, little information is available on chemical compounds that are able to influence this process. We aimed to discover novel compounds that are able to induce flowering in the model plant Arabidopsis. For this purpose we developed a plant-based screening platform that can be used in a chemical genomics study...
2017: Plant Methods
Cui Ye, Min Qiang Wang, Hong Qun Luo, Nian Bing Li
MicroRNAs (miRNAs) quantification, especially for their low abundance, is vital for diseases diagnosis, prognosis, and therapy, while plentiful miRNA assays seek extreme signal amplification strategies and ignore the increased background signal. Herein we develop a distinctive label-free "off-on" configuration for photoelectrochemical (PEC) sensing platform fabrication, coupling with DNA four-way junction (4J) architecture as well as G-wire superstructure for signal amplification, and ultrathin copper phosphate nanosheets (CuPi NSs) coating Au nanoparticles (Au-CuPi NSs) serving as highly efficient photocathode substrate...
October 11, 2017: Analytical Chemistry
D Hatanaka, T Darras, I Mahboob, K Onomitsu, H Yamaguchi
The high-quality-factor mechanical resonator in electromechanical systems has facilitated dynamic control of phonons via parametric nonlinear processes and paved the development of mechanical logic-elements. However, the narrow spectral bandwidth of the resonating element constrains the available nonlinear phenomena thus limiting the functionality of the device as well as the switching speeds. Here we have developed phonon waveguides, with a two-octave-wide phonon transmission band, in which mechanical four-wave-like mixing is demonstrated that enables the frequency of phonon waves to be converted over 1 MHz...
October 6, 2017: Scientific Reports
E Lucas, M Karpov, H Guo, M L Gorodetsky, T J Kippenberg
Dissipative solitons are self-localised structures resulting from the double balance of dispersion by nonlinearity and dissipation by a driving force arising in numerous systems. In Kerr-nonlinear optical resonators, temporal solitons permit the formation of light pulses in the cavity and the generation of coherent optical frequency combs. Apart from shape-invariant stationary solitons, these systems can support breathing dissipative solitons exhibiting a periodic oscillatory behaviour. Here, we generate and study single and multiple breathing solitons in coherently driven microresonators...
September 29, 2017: Nature Communications
Chao Zhou, Xiaoyang Duan, Na Liu
The development of DNA nanotechnology, especially the advent of DNA origami, has made DNA ideally suited to construct nanostructures with unprecedented complexity and arbitrariness. As a fully addressable platform, DNA origami can be used to organize discrete entities in space through DNA hybridization with nanometer accuracy. Among a variety of functionalized particles, metal nanoparticles such as gold nanoparticles (AuNPs) feature an important pathway to endow DNA-origami-assembled nanostructures with tailored optical functionalities...
September 27, 2017: Accounts of Chemical Research
Edwin Michael, Brajendra K Singh, Benjamin K Mayala, Morgan E Smith, Scott Hampton, Jaroslaw Nabrzyski
BACKGROUND: There are growing demands for predicting the prospects of achieving the global elimination of neglected tropical diseases as a result of the institution of large-scale nation-wide intervention programs by the WHO-set target year of 2020. Such predictions will be uncertain due to the impacts that spatial heterogeneity and scaling effects will have on parasite transmission processes, which will introduce significant aggregation errors into any attempt aiming to predict the outcomes of interventions at the broader spatial levels relevant to policy making...
September 27, 2017: BMC Medicine
Thu H H Le, Takuo Tanaka
One of the most attractive potentials of plasmonic metamaterials is the amplification of intrinsically weak signals such as molecular infrared absorption or Raman scattering for detection applications. This effect, however, is only effective when target molecules are located at the enhanced electromagnetic field of the plasmonic structures (i.e., hot-spots). It is thus of significance to control the spatial overlapping of molecules and hot-spots, yet it is a long-standing challenge, since it involves the handling of molecules in nanoscale spaces...
September 28, 2017: ACS Nano
Yijun Zheng, Xiao Liu, Jiajia Xu, Huaixia Zhao, Xinhong Xiong, Xu Hou, Jiaxi Cui
Liquid-based mobile interfaces, in which liquids are being utilized as structural long-term components, have shown their multifunctionality in materials science, such as the hydration layer of polyelectrolyte brushes used for artificial implants, stabilized lubricants for antibiofouling, anti-icing, self-cleaning, optical control, and so forth. However, these currently available systems do not usually show a response to environmental stimuli. Here, we describe a strategy for preparing thermoresponsive mobile interfaces made from novel silicone-based lubricants that display lower critical solution temperature and demonstrate their capabilities on controlling in situ water wetting and dewetting, thermo-gating penetration, and optical properties...
October 11, 2017: ACS Applied Materials & Interfaces
Jürgen Kopitz, Qi Xiao, Anna-Kristin Ludwig, Antonio Romero, Malwina Michalak, Samuel E Sherman, Xuhao Zhou, Cody Dazen, Sabine Vértesy, Herbert Kaltner, Michael L Klein, Hans-Joachim Gabius, Virgil Percec
Chemical and biological tools are harnessed to investigate the impact of spatial factors for functional pairing of human lectins with counterreceptors. The homodimeric adhesion/growth-regulatory galectin-1 and a set of covalently linked homo-oligomers from di- to tetramers serve as proof-of-principle test cases. Glycodendrimersomes provide a versatile and sensitive diagnostic platform to reveal thresholds for ligand density and protein concentration in aggregation assays (trans-activity), irrespective of linker length between lectin domains...
September 22, 2017: Angewandte Chemie
Salma Kassem, Alan T L Lee, David A Leigh, Vanesa Marcos, Leoni I Palmer, Simone Pisano
It has been convincingly argued that molecular machines that manipulate individual atoms, or highly reactive clusters of atoms, with Ångström precision are unlikely to be realized. However, biological molecular machines routinely position rather less reactive substrates in order to direct chemical reaction sequences, from sequence-specific synthesis by the ribosome to polyketide synthases, where tethered molecules are passed from active site to active site in multi-enzyme complexes. Artificial molecular machines have been developed for tasks that include sequence-specific oligomer synthesis and the switching of product chirality, a photo-responsive host molecule has been described that is able to mechanically twist a bound molecular guest, and molecular fragments have been selectively transported in either direction between sites on a molecular platform through a ratchet mechanism...
September 20, 2017: Nature
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