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https://www.readbyqxmd.com/read/28433982/acute-on-chronic-gastrointestinal-bleeding-a-unique-clinical-entity
#1
Don C Rockey, Adam C Hafemeister, Joan S Reisch
Gastrointestinal bleeding is defined in temporal-spatial terms-as acute or chronic, and/or by its location in the gastrointestinal tract. Here, we define a distinct type of bleeding, which we have coined 'acute on chronic' gastrointestinal bleeding. We prospectively identified all patients who underwent endoscopic evaluation for any form of gastrointestinal bleeding at a University Hospital. Acute on chronic bleeding was defined as the presence of new symptoms or signs of acute bleeding in the setting of chronic bleeding, documented as iron deficiency anemia...
April 21, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28433637/inhibition-of-pro-inflammatory-enzymes-by-medicinal-plants-from-the-argentinean-highlands-puna
#2
Romina Torres-Carro, María Inés Isla, Samanta Thomas-Valdes, Felipe Jiménez-Aspee, Guillermo Schmeda-Hirschmann, María Rosa Alberto
ETHNOPHARMACOLOGICAL RELEVANCE: Human groups in the Argentinean Andes highlands (Puna) selected native plants as anti-inflammatory agents. The indications of use are mainly to relieve pain, in infusions, ethanolic extracts or plasters. AIM OF THE STUDY: The objective of the study was to assess the effect of hydroalcoholic extracts from native highland plants as anti-inflammatory according to the traditional indications of use. The chemical profile of the three most active species was analyzed by HPLC-ESI-MS to get in insight into the constituents and the effects observed, according to the ethnopharmacological information...
April 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28433004/plackett-burman-design-and-response-surface-optimization-of-medium-trace-nutrients-for-glycolipopeptide-biosurfactant-production
#3
Maurice George Ekpenyong, Sylvester Peter Antai, Atim David Asitok, Bassey Offiong Ekpo
Background: A glycolipopeptide biosurfactant produced by Pseudomonas aeruginosa strain IKW1 reduced the surface tension of fermentation broth from 71.31 to 24.62 dynes/cm at a critical micelle concentration of 20.80 mg/L. The compound proved suitable for applications in emulsion stabilization in food, as well as in cosmetic and pharmaceutical formulations. Method: In the present study, Plackett-Burman design (PBD) and response surface method (RSM) were employed to screen and optimize concentrations of trace nutrients in the fermentation medium, to increase surfactant yield...
April 23, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28432891/modification-of-an-existing-in%C3%A2-vitro-method-to-predict-relative-bioavailable-arsenic-in-soils
#4
Shane Whitacre, Nicholas Basta, Brooke Stevens, Valerie Hanley, Richard Anderson, Kirk Scheckel
The soil matrix can sequester arsenic (As) and reduces its exposure by soil ingestion. In vivo dosing studies and in vitro gastrointestinal (IVG) methods have been used to predict relative bioavailable (RBA) As. Originally, the Ohio State University (OSU-IVG) method predicted RBA As for soils exclusively from mining and smelting sites with a median of 5,636 mg As kg(-1). The objectives of the current study were to (i) evaluate the ability of the OSU-IVG method to predict RBA As for As contaminated soils with a wider range of As content and As contaminant sources, and (ii) evaluate a modified extraction procedure's ability to improve prediction of RBA As...
April 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28432630/the-influence-of-restoration-measures-on-phosphorus-internal-loading-from-the-sediments-of-a-hypereutrophic-lake
#5
Katarzyna Kowalczewska-Madura, Renata Dondajewska, Ryszard Gołdyn, Stanisław Podsiadłowski
Uzarzewskie Lake was a hypereutrophic, dimictic lake characterized by low water transparency, high chlorophyll-a concentration and intense phytoplankton blooms; thus, restoration treatment was started. A chemical treatment, based on phosphorus inactivation with small doses of iron sulphate, was undertaken in 2006-2007. Nitrate-rich groundwater flowing from seepage springs was directed into the lake hypolimnion to increase redox potential since 2008. Phosphorus internal loading was reduced by more than 80% as a result of restoration treatment...
April 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28431390/sulfonamides-photoassisted-oxidation-treatments-catalyzed-by-ilmenite
#6
P García-Muñoz, G Pliego, J A Zazo, A Bahamonde, J A Casas
This work assesses the feasibility of several advanced oxidation processes (CWPO Catalytic Wet Peroxide Oxidation), Photocatalysis and their combination (CWPO-Photoassisted process) for sulfonamide antibiotic degradation. Raw ilmenite was used as catalyst in both processes, because of the presence of iron and titanium in its structure. Despite both treatments allowed reaching a total starting antibiotic depletion working at pH0 = 3 and T0 = 30 °C within 30 min reaction time, significant differences were observed in terms of mineralization...
April 18, 2017: Chemosphere
https://www.readbyqxmd.com/read/28430959/expression-immunogenicity-and-variation-of-iron-regulated-surface-protein-a-from-bovine-isolates-of-staphylococcus-aureus
#7
N Misra, T F Wines, C L Knopp, M A McGuire, J K Tinker
Staphylococcus aureus iron-regulated surface protein A (IsdA) is a fibrinogen and fibronectin adhesin that also contributes to iron sequestration and resistance to innate immunity. IsdA is conserved in human isolates and has been investigated as a human vaccine candidate. Here we report the expression of isdA, the efficacy of anti-IsdA responses, and the existence of IsdA sequence variants from bovine Staphylococcus. Clinical staphylococci were obtained from U.S. dairy farms and assayed by PCR for the presence and expression of isdA...
April 19, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28430950/effects-of-dissolved-oxygen-concentration-and-iron-addition-on-immediate-early-gene-expression-of-magnetospirillum-gryphiswaldense-msr-1
#8
Shiwen Zhuang, Diana Chinyere Anyaogu, Takeshi Kasama, Mhairi Workman, Uffe Hasbro Mortensen, Timothy John Hobley
We report effects of dissolved oxygen (DO) concentration and iron addition on gene expression of Magnetospirillum gryphiswaldense MSR-1 cells during fermentations, focusing on 0.25-24 h after iron addition. The DO was strictly controlled at 0.5% or 5% O2, and compared with aerobic condition. Uptake of iron (and formation of magnetosomes) was only observed in the 0.5% O2 condition where there was little difference in cell growth and carbon consumption compared to the 5% O2 condition. Quantitative reverse transcription PCR analysis showed a rapid (within 0...
April 19, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28430017/two-nramp6-isoforms-function-as-iron-and-manganese-transporters-and-contribute-to-disease-resistance-in-rice
#9
Cristina Peris-Peris, Albert Serra-Cardona, Ferrán Sánchez-Sanuy, Sonia Campo, Joaquin Ariño, Blanca San Segundo
Metal ions are essential elements for all living organisms. However, metals can be toxic when present in excess. In plants, metal homeostasis is partly achieved through the function of metal transporters, including the diverse natural resistance-associated macrophage proteins (NRAMP). Among them, the OsNramp6 gene encodes a previously uncharacterized member of the rice NRAMP family that undergoes alternative splicing to produce different NRAMP6 proteins. In this work, we determined the metal transport activity and biological role of the full-length and the shortest NRAMP6 proteins (l-NRAMP6 and s-NRAMP6, respectively)...
April 21, 2017: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/28428774/biochar-addition-increases-the-rates-of-dissimilatory-iron-reduction-and-methanogenesis-in-ferrihydrite-enrichments
#10
Guo-Wei Zhou, Xiao-Ru Yang, Christopher W Marshall, Hu Li, Bang-Xiao Zheng, Yu Yan, Jian-Qiang Su, Yong-Guan Zhu
Biochar contains quinones and aromatic structures that facilitate extracellular electron transfer between microbial cells and insoluble minerals. In this study, granulated biochar (1.2-2 mm) and powdered biochar (<0.15 mm) were amended to two ferrihydrite (in situ ferrihydrite and ex situ ferrihydrite) enrichments to investigate the effect of biochar with different particle sizes on dissimilatory iron(III)-reducing bacteria (DIRB) and methanogens. Biochar addition significantly stimulated the reduction of both in situ ferrihydrite and ex situ ferrihydrite and the production of methane...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28426929/exerting-enhanced-permeability-and-retention-effect-driven-delivery-by-ultrafine-iron-oxide-nanoparticles-with-t1-t2-switchable-magnetic-resonance-imaging-contrast
#11
Liya Wang, Jing Huang, Hongbo Chen, Hui Wu, Yaolin Xu, Yuancheng Li, Hong Yi, Yongqiang Andrew Wang, Lily Yang, Hui Mao
The poor delivery efficiency remains a major challenge in nanomaterial based tumor targeted imaging and drug delivery. This work demonstrated a strategy to improve nanoparticle delivery and intratumoral distribution using a sub-5 nm (3.5 nm core size) ultrafine iron oxide nanoparticles (uIONPs) that can easily extravasate from the tumor vasculature and readily diffuse into the tumor tissue compared to iron oxide nanoparticles (IONP) with larger sizes, followed by self-assembling in the acidic tumor interstitial space to limit their re-entering the circulation...
April 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28426828/consumption-of-fortified-infant-foods-reduces-dietary-diversity-but-has-a-positive-effect-on-subsequent-growth-in-infants-from-sumedang-district-indonesia
#12
Aly Diana, Simonette R Mallard, Jillian J Haszard, Dwi Monik Purnamasari, Ikrimah Nurulazmi, Pratami D Herliani, Gaga I Nugraha, Rosalind S Gibson, Lisa Houghton
Stunting and underweight among under-five children in Indonesia are common, raising public health concerns. Whether inappropriate complementary feeding (CF) practices compromise optimal growth during late infancy in Indonesia is uncertain. Therefore we characterized and evaluated CF practices in Indonesian infants and investigated their relationship with subsequent growth. We enrolled breastfed infants at 6 months of age (n = 230); and followed them at 9 (n = 202) and 12 months of age (n = 190). We collected socio-demographic and anthropometric data and two-day in-home weighed food records...
2017: PloS One
https://www.readbyqxmd.com/read/28425182/serum-ferritin-thresholds-for-the-diagnosis-of-iron-deficiency-in-pregnancy-a-systematic-review
#13
REVIEW
J Daru, J Allotey, J P Peña-Rosas, K S Khan
The aim of this review was to understand the landscape of serum ferritin in diagnosing iron deficiency in the aetiology of anaemia in pregnancy. Iron deficiency in pregnancy is a major public health problem leading to the development of anaemia. Reducing the global prevalence of anaemia in women of reproductive age is a 2025 global nutrition target. Bone marrow aspiration is the gold standard test for iron deficiency but requires an invasive procedure; therefore, serum ferritin is the most clinically useful test...
April 20, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28424794/study-design-and-baseline-results-of-an-open-label-cluster-randomized-community-intervention-trial-to-assess-the-effectiveness-of-a-modified-mass-deworming-program-in-reducing-hookworm-infection-in-a-tribal-population-in-southern-india
#14
Rajiv Sarkar, Anuradha Rose, Venkata R Mohan, Sitara S R Ajjampur, Vasanthakumar Veluswamy, Rajan Srinivasan, Jayaprakash Muliyil, Vedantam Rajshekhar, Kuryan George, Vinohar Balraj, Nicholas C Grassly, Roy M Anderson, Simon J Brooker, Gagandeep Kang
INTRODUCTION: Hookworm infection is a leading cause of iron deficiency anemia and malnutrition in resource-poor settings. Periodic mass deworming with anthelminthic drugs remains the cornerstone of hookworm control efforts worldwide. Reinfection following treatment occurs, reflecting the human host's inability to acquire immunity following exposure to an untreated reservoir of infection. This cluster randomized trial will evaluate the effectiveness of a modified, population-based, mass deworming strategy in reducing hookworm infection in an endemic southern Indian population...
March 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/28424257/an-animal-source-food-supplement-increases-micronutrient-intakes-and-iron-status-among-reproductive-age-women-in-rural-vietnam
#15
Andrew G Hall, Tu Ngu, Hoang T Nga, Phi N Quyen, Pham T Hong Anh, Janet C King
Background: Few studies have examined the impact of local animal-source foods (ASFs) on the nutritional status of reproductive-age women in developing countries.Objective: We hypothesized that a midmorning snack of local ASF for 6 mo would reduce dietary micronutrient deficiencies [usual intake less than the estimated average requirement (EAR)] and improve blood biomarkers of iron, zinc, and vitamins A and B-12 status among nonpregnant, reproductive-age women in rural Vietnam.Methods: One hundred seventeen women, 18-30 y old, were randomly assigned to receive either an ASF (mean: 144 kcal, 8...
April 19, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28421792/micronutrient-supplementation-in-gastric-bypass-surgery-prospective-study-on-in%C3%AF-ammation-and-iron-metabolism-in-premenopausal-women
#16
Flávia Andréia Marin, Rozangela Verlengia, Alex Harley Crisp, Patrícia Fátima Sousa Novais, Irineu Rasera-Junior, Maria Rita Marques De Oliveira
BACKGROUND: Low-grade chronic inflammation in morbid obesity is associated with impaired iron metabolism. Bariatric surgery is effective in weight loss; however, it can induce specific nutritional deficiencies, such as iron, especially in premenopausal women. Alternatively, after surgery, there is an improvement in systemic inflammation, raising questions concerning the dosages of micronutrient supplementation. OBJECTIVES: This study aimed to assess the effect of two micronutrient supplementation schemes before and 6 months after a Roux-en-Y gastric bypass (RYGB) surgery on inflammation and iron metabolism in premenopausal women...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28421266/reactive-oxygen-species-mediated-t-lymphocyte-abnormalities-in-an-iron-overloaded-mouse-model-and-iron-overloaded-patients-with-myelodysplastic-syndromes
#17
Jie Chen, Wen-Yi Lu, Ming-Feng Zhao, Xiao-Li Cao, Yan-Yu Jiang, Xin Jin, Ping Xu, Ting-Ting Yuan, Yu-Chen Zhang, Xiao Chai, Juan-Xia Meng, Qing Li, Xia Xiao, Juan Mu, De-Guan Li, Ai-Ping Qi
The adverse effects of iron overload have raised more concerns as a growing number of studies reported its association with immune disorders. This study aimed to investigate alterations in the immune system by iron overload in patients with myelodysplastic syndrome (MDS) and an iron-overloaded mouse model. The peripheral blood from patients was harvested to test the effect of iron overload on the subsets of T lymphocytes, and the level of reactive oxygen species (ROS) was also evaluated. The data showed that iron-overloaded patients had a lower percentage of CD3(+) T cells and disrupted T cell subsets, concomitant with higher ROS level in lymphocytes...
April 18, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28421129/protective-effects-of-dinitrosyl-iron-complexes-under-oxidative-stress-in-the-heart
#18
Valery I Kapelko, Vladimir L Lakomkin, Alexander A Abramov, Elena V Lukoshkova, Nidas A Undrovinas, Asker Y Khapchaev, Vladimir P Shirinsky
Background. Nitric oxide can successfully compete with oxygen for sites of electron-transport chain in conditions of myocardial hypoxia. These features may prevent excessive oxidative stress occurring in cardiomyocytes during sudden hypoxia-reoxygenation. Aim. To study the action of the potent stable NO donor dinitrosyl iron complex with glutathione (Oxacom®) on the recovery of myocardial contractile function and Ca(2+) transients in cardiomyocytes during hypoxia-reoxygenation. Results. The isolated rat hearts were subjected to 30 min hypoxia followed by 30 min reoxygenation...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28421060/the-heme-metabolite-carbon-monoxide-facilitates-kshv-infection-by-inhibiting-tlr4-signaling-in-endothelial-cells
#19
Sara Botto, Jean K Gustin, Ashlee V Moses
Kaposi sarcoma herpesvirus (KSHV) is the etiologic agent of Kaposi sarcoma (KS) and certain rare B cell lymphoproliferative disorders. KSHV infection of endothelial cells (EC) in vitro increases expression of the inducible host-encoded enzyme heme oxygenase-1 (HO-1), which is also strongly expressed in KS tumors. HO-1 catalyzes the rate-limiting step in the conversion of heme into iron, biliverdin and the gasotransmitter carbon monoxide (CO), all of which share anti-apoptotic, anti-inflammatory, pro-survival, and tumorigenic activities...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28419895/electrochemical-oxidation-of-iron-and-alkalinity-generation-for-efficient-sulfide-control-in-sewers
#20
Hui-Wen Lin, Caroline Kustermans, Eleni Vaiopoulou, Antonin Prévoteau, Korneel Rabaey, Zhiguo Yuan, Ilje Pikaar
The addition of iron salts is one of the most commonly used dosing strategies for sulfide control in sewers. However, iron salts decrease the sewage pH which not only reduces the effectiveness of sulfide precipitation but also enhances the release of residual sulfide to the sewer atmosphere. Equally important, concentrated iron salt solutions are corrosive and their frequent transport, handling, and on-site storage often come with Occupational Health and Safety (OH&S) concerns. Here, we experimentally demonstrated a novel sulfide control approach using electrochemical systems with parallel placed iron electrodes...
April 15, 2017: Water Research
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