keyword
MENU ▼
Read by QxMD icon Read
search

Keratin

keyword
https://www.readbyqxmd.com/read/29445174/a-spatial-gradient-of-bacterial-diversity-in-the-human-oral-cavity-shaped-by-salivary-flow
#1
Diana M Proctor, Julia A Fukuyama, Peter M Loomer, Gary C Armitage, Stacey A Lee, Nicole M Davis, Mark I Ryder, Susan P Holmes, David A Relman
Spatial and temporal patterns in microbial communities provide insights into the forces that shape them, their functions and roles in health and disease. Here, we used spatial and ecological statistics to analyze the role that saliva plays in structuring bacterial communities of the human mouth using >9000 dental and mucosal samples. We show that regardless of tissue type (teeth, alveolar mucosa, keratinized gingiva, or buccal mucosa), surface-associated bacterial communities vary along an ecological gradient from the front to the back of the mouth, and that on exposed tooth surfaces, the gradient is pronounced on lingual compared to buccal surfaces...
February 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29441510/translating-the-combination-of-gene-therapy-and-tissue-engineering-for-treating-recessive-dystrophic-epidermolysis-bullosa
#2
A Dakiw Piaceski, D Larouche, K Ghani, F Bisson, S Cortez Ghio, S Larochelle, M J Moulin, M Caruso, L Germain
The combination of gene therapy and tissue engineering is one of the most promising strategies for the treatment of recessive dystrophic epidermolysis bullosa (RDEB). RDEB is a rare genetic disease characterised by mutations in the COL7A1 gene, encoding type VII collagen (COLVII), which forms anchoring fibrils at the dermal-epidermal junction of the skin. This disease causes severe blistering and only palliative treatments are offered. In this study, the base of a strategy combining gene therapy and a tissue-engineered skin substitute (TES), which would be suitable for the permanent closure of skin wounds, was set-up...
February 14, 2018: European Cells & Materials
https://www.readbyqxmd.com/read/29440859/nevus-comedonicus-on-scalp-an-unusual-presentation
#3
Priyadarshini Sahu, Kamal Aggrawal, Chetna Bansal, V K Jain
Nevus comedonicus (NC) is a rare developmental anomaly of follicular infundibulum plugged with keratinous material that resembles comedo-like lesions. Frequently affected sites are face, neck, trunk, and upper arm. Few cases have been described on palms, soles, scalp, and genitalia. We hereby report a rare case of NC on scalp in a 14-year-old boy.
January 2018: International Journal of Trichology
https://www.readbyqxmd.com/read/29440855/circle-hairs-involving-the-extremities-in-a-young-girl
#4
Pragya Ashok Nair, Trusha Patel, Radhika Navadiya
Circle hairs (CHs) represent a body hair growth disorder which is characterized by asymptomatic presence of hairs in typical circular or spiraliform arrangement. It is not associated with follicular or inflammatory abnormalities. CHs are rarely reported, probably underestimated, as medical consultation for CH only is rare in practice. It needs to be differentiated from rolled hairs, which is a relatively common disorder of hair growth associated with follicular hyperkeratosis and keratin plugging. Trichoscopy is a noninvasive technique to confirm the diagnosis without biopsy...
January 2018: International Journal of Trichology
https://www.readbyqxmd.com/read/29440219/wool-derived-keratin-dressings-versus-usual-care-dressings-for-treatment-of-slow-healing-venous-leg-ulceration-study-protocol-for-a-randomised-controlled-trial-keratin4vlu
#5
Andrew Jull, Angela Wadham, Chris Bullen, Varsha Parag, Jill Waters
INTRODUCTION: Keratins, filament-forming proteins found in vertebrate epithelium, are downregulated in slow-healing venous leg ulcers (VLU) compared with normal-healing VLU. Laboratory and animal model research has suggested exogenous keratins increase expression of endogenous keratins. A non-randomised controlled trial of an exogenous keratin dressing reported increased healing in slow-healing VLU. To date, no randomised controlled trial has been done to verify these promising findings...
February 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/29439906/dermoid-cysts-of-the-conus-medullaris-clinical-review-case-series-and-management-strategies
#6
Salah G Aoun, Mary Ashley Liu, Megan Still, Tarek Y El Ahmadieh, Mazin Al Tamimi, Wayne Gluf
BACKGROUND: The management of dermoid cysts can be tedious as they have a tendency to recur, and respond poorly to chemotherapy and radiation. Management is especially difficult for tumors involving highly eloquent areas such as the conus medullaris. OBJECTIVE: We aim to provide a summary of the pathology, clinical presentation, and operative management strategies of dermoid cysts involving the conus medullaris. METHODS: Two clinical cases of dermoid cysts of the conus are presented, as well as a commented surgical video...
February 10, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29439243/atomic-structures-of-low-complexity-protein-segments-reveal-kinked-%C3%AE-sheets-that-assemble-networks
#7
Michael P Hughes, Michael R Sawaya, David R Boyer, Lukasz Goldschmidt, Jose A Rodriguez, Duilio Cascio, Lisa Chong, Tamir Gonen, David S Eisenberg
Subcellular membraneless assemblies are a reinvigorated area of study in biology, with spirited scientific discussions on the forces between the low-complexity protein domains within these assemblies. To illuminate these forces, we determined the atomic structures of five segments from protein low-complexity domains associated with membraneless assemblies. Their common structural feature is the stacking of segments into kinked β sheets that pair into protofilaments. Unlike steric zippers of amyloid fibrils, the kinked sheets interact weakly through polar atoms and aromatic side chains...
February 9, 2018: Science
https://www.readbyqxmd.com/read/29438785/low-molecular-weight-keratins-with-anti-skin-aging-activity-produced-by-anaerobic-digestion-of-poultry-feathers-with-fervidobacterium-islandicum-aw-1
#8
Inhyuk Yeo, Yong-Jik Lee, Kyeongseop Song, Hyeon-Su Jin, Jae-Eun Lee, Dajeong Kim, Dong-Woo Lee, Nam Joo Kang
Bioactive peptides contribute to various cellular processes including improved skin physiology. Hence, bioactive keratins have attracted considerable attention as active cosmetic ingredients for skin health. Here, we obtained low molecular weight (LMW) keratins from native chicken feathers by anaerobic digestion with an extremely thermophilic bacterium Fervidobacterium islandicum AW-1, followed by stepwise fractionation through ultrafiltration. To assess the effects of the feather keratins on skin health, we performed in vitro and ex vivo assays to investigate their inhibitory effects on matrix metalloproteinases (MMPs)...
February 10, 2018: Journal of Biotechnology
https://www.readbyqxmd.com/read/29436209/focus-on-gastroesophageal-reflux-ger-and-laryngopharyngeal-reflux-lpr-new-pragmatic-insights-in-clinical-practice
#9
M Gelardi, G Ciprandi
Gastroesophageal reflux (GER) is a common disease usually limited to the oesophagus. Laryngopharyngeal reflux (LPR) is an inflammatory reaction of the mucosa of pharynx, larynx, and other associated upper respiratory organs, caused by a reflux of stomach contents outside the oesophagus. LPR is considered to be a relatively new clinical entity with a vast number of clinical manifestations which are treated sometimes empirically and without a correct diagnosis. However, there is disagreement between specialists about its definition and management: gastroenterologists consider LPR to be a substantially rare manifestation of gastroesophageal reflux disease (GERD), whereas otolaryngologists believe that LPR is an independent, but common in their practice, disorder...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29435078/gene-expression-analyses-associated-with-malignant-phenotypes-of-metastatic-sub-clones-derived-from-a-mouse-oral-squamous-cell-carcinoma-sq-1979-cell-line
#10
Mitsutaka Adachi, Masako Mizuno-Kamiya, Eiji Takayama, Harumi Kawaki, Toshihiro Inagaki, Shigeki Sumi, Masayuki Motohashi, Yasunori Muramatsu, Shin-Ichiro Sumitomo, Michio Shikimori, Yutaka Yamazaki, Nobuo Kondoh
To elucidate the genetic events that occur during the development of OSCC, the present study established a model of oral malignancy using a mouse oral squamous cell carcinoma (OSCC) Sq-1979 cell line. Sq-1979 cells were implanted into syngeneic C3H mice. Subsequently, 233 cells and metastatic sub-clones (L cells) from primary OSCC, as well as the metastasized lymph node tissues of Sq-1979-implanted mice were established. Compared with parental Sq-1979 and 233 cells, the majority of L cells exhibited a higher proliferation rate and transplantability, and conferred a lower survival rate on the implanted mice...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434339/epidemiology-and-biomarker-profile-of-pituitary-adenohypophysial-tumors
#11
Ozgur Mete, Amber Cintosun, Irwin Pressman, Sylvia L Asa
Recent studies have reported the prevalence of pituitary tumors to be ~1/1000 population. Many are prolactin-producing tumors that are managed medically, however, the epidemiology of surgically resected pituitary adenohypophysial neuroendocrine tumors has not been reported in a large series with detailed characterization. We reviewed 1055 adenohypophysial tumors from 1169 transsphenoidal resections from the pathology files of University Health Network, Toronto, 2001-2016. Tumors were characterized by immunohistochemical localization of transcription factors (Pit-1, ERα, SF-1, Tpit), hormones (adrenocorticotropin, growth hormone, prolactin, β-thyrotropin, β-folliculotropin, β-luteotropin, α-subunit), and other biomarkers (keratins, Ki67, p27, FGFR4)...
February 12, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29433752/irradiation-of-rainbow-trout-at-early-life-stages-results-in-a-proteomic-legacy-in-adult-gills-part-b-the-effect-of-a-second-radiation-dose-after-one-year-on-the-proteomic-responses-in-the-irradiated-and-non-irradiated-bystander-fish
#12
Richard W Smith, Richard D Moccia, Carmel E Mothersill, Colin B Seymour
This study extends the investigation of the legacy effects of exposure to a single radiation dose at one of four early life stages, in adult rainbow trout (Part A), by examining the effects of a second identical dose after one year; i.e. egg 48 h after fertilisation (48 h egg) + 1 year, eyed egg + 1 year, yolk sac larvae (YSL) + 1 year and first feeder + 1 year. This included the induction of a bystander effect in non-irradiated trout which had swam with the irradiated fish. The second radiation dose negated any beneficial proteomic responses following early life stage irradiation only, particularly irradiation of 48 h eggs and eyed eggs (Part A)...
February 9, 2018: Environmental Research
https://www.readbyqxmd.com/read/29430682/enolase-1-expression-in-the-stratum-corneum-is-elevated-with-parakeratosis-of-atopic-dermatitis-and-disrupts-the-cellular-tight-junction-barrier-in-keratinocytes
#13
Takeshi Tohgasaki, Naoko Ozawa, Takashi Yoshino, Shioji Ishiwatari, Shoko Matsukuma, Shigeru Yanagi, Hidetsugu Fukuda
OBJECTIVE: Previous studies have shown that enolase-1 (ENO1) in the stratum corneum (SC) is more highly expressed in patients with atopic dermatitis (AD) than in healthy individuals, suggesting that it is a novel biomarker for evaluating skin condition in patients with AD. However, the mechanism underlying high ENO1 expression in the SC and its pathological relevance in AD are unclear. In this study, the relationship between ENO1 expression and keratinization of epidermis was investigated and the role of high ENO1 expression in keratinocytes was characterized...
February 11, 2018: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29430368/molecular-and-biochemical-characterization-of-a-thermostable-keratinase-from-bacillus-altitudinis-rbdv1
#14
Vishakha A Pawar, Anil S Prajapati, Rekha C Akhani, Darshan H Patel, R B Subramanian
A thermostable keratinase designated as KBALT was purified from Bacillus altitudinis RBDV1 from a poultry farm in Gujarat, India. The molecular weight of the native KBALT (nKBALT) purified using ammonium sulfate and ion exchange and gel permeation chromatography with a 40% yield and 80-fold purification was estimated to be ~ 43 kDa. The gene for KBALT was successfully cloned, sequenced and expressed in Escherichia coli. Recombinant KBALT (rKBALT) when purified using a single step Ni-NTA His affinity chromatography achieved a yield of 38...
February 2018: 3 Biotech
https://www.readbyqxmd.com/read/29429303/biodegradation-of-feather-waste-keratin-by-a-keratin-degrading-strain-of-bacillus-subtilis-8
#15
Zhoufeng He, Rong Sun, Zizhong Tang, Tongliang Bu, Qi Wu, Chenlei Li, Hui Chen
Bacillus subtilis 8 is highly efficient at degrading feather keratin. We observed integrated feather degradation over the course of 48 h in basic culture medium while studying the entire process with scanning electron microscopy. Large amounts of ammonia, sulfite, and L-cysteic acid were detected in fermented liquid. In addition, four enzymes (Gamma-glutamyltranspeptidase, Peptidase T, Serine protease and Cystathionine gamma-synthase) were identified that play an important role in this degradation pathway, all of which were verified with molecular cloning and prokaryotic expression...
February 13, 2018: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29427328/depletion-of-keratin-8-18-modulate-oncogenic-potential-by-governing-multiple-signaling-pathways
#16
Richa Tiwari, Indrajit Sahu, Bihari Lal Soni, Gajanan J Sathe, Pankaj Thapa, Pavan Patel, Shruti Sinha, Chella Krishna Vadivel, Shweta Patel, Sayli Nitin Jamghare, Swapnil Oak, Rahul Thorat, Harsha Gowda, Milind M Vaidya
Keratin 8/18 the predominant keratin pair of simple epithelia is often aberrantly expressed in various squamous cell carcinomas (SCCs) including skin-SCC. Its aberrant expression is correlated with increased invasiveness and poor prognosis of the same, although the underlying mechanism is still unclear. A previous report from our laboratory has shown K8 mediated regulation of α6β4 integrin signaling and thereby tumorigenic potential of oral-SCC derived cells. Another study on transgenic mouse model has shown that during skin carcinogenesis, K8 favors conversion of papillomas towards malignancy...
February 10, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29427031/unusual-multinucleated-giant-cell-reaction-in-a-tongue-squamous-cell-carcinoma-histopathological-and-immunohistochemical-features
#17
Celeste Sánchez-Romero, Roman Carlos, Ciro Dantas Soares, Oslei Paes de Almeida
Multinucleated giant cell (MGC) reaction in oral squamous cell carcinoma (OSCC) usually represents a stromal foreign body reaction to keratin from neoplastic epithelial cells. We describe and illustrate by double immunohistochemistry a case of a tongue squamous cell carcinoma (SCC) in a 70-year-old female patient, with a copious MGC reaction not associated to keratin, showing a histopathological pattern not described before. The MGCs were directly associated with neoplastic cells, which are phagocytosed by the MGCs...
February 9, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29422656/methylation-profiling-identifies-two-subclasses-of-squamous-cell-carcinoma-related-to-distinct-cells-of-origin
#18
Manuel Rodríguez-Paredes, Felix Bormann, Günter Raddatz, Julian Gutekunst, Carlota Lucena-Porcel, Florian Köhler, Elisabeth Wurzer, Katrin Schmidt, Stefan Gallinat, Horst Wenck, Joachim Röwert-Huber, Evgeniya Denisova, Lars Feuerbach, Jeongbin Park, Benedikt Brors, Esther Herpel, Ingo Nindl, Thomas G Hofmann, Marc Winnefeld, Frank Lyko
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and usually progresses from a UV-induced precancerous lesion termed actinic keratosis (AK). Despite various efforts to characterize these lesions molecularly, the etiology of AK and its progression to cSCC remain partially understood. Here, we use Infinium MethylationEPIC BeadChips to interrogate the DNA methylation status in healthy, AK and cSCC epidermis samples. Importantly, we show that AK methylation patterns already display classical features of cancer methylomes and are highly similar to cSCC profiles...
February 8, 2018: Nature Communications
https://www.readbyqxmd.com/read/29422532/type-iv-collagen-%C3%AE-6-chain-is-a-regulator-of-keratin-10-in-keratinization-of-oral-mucosal-epithelium
#19
Taishi Komori, Mitsuaki Ono, Emilio Satoshi Hara, Junji Ueda, Ha Thi Thu Nguyen, Ha Thi Nguyen, Tomoko Yonezawa, Takahiro Maeba, Aya Kimura-Ono, Takeshi Takarada, Ryusuke Momota, Kenji Maekawa, Takuo Kuboki, Toshitaka Oohashi
Keratinized mucosa is of fundamental importance to maintain healthy gingival tissue, and understanding the mechanisms of oral mucosa keratinization is crucial to successfully manage healthy gingiva. Previous studies have shown a strong involvement of the basement membrane in the proliferation and differentiation of epithelial cells. Therefore, first, to identify the keratinized mucosa-specific basement membrane components, immunohistochemical analysis for the six alpha chains of type IV collagen was performed in 8-week-old mice...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29422292/autoinflammatory-keratinization-diseases-an-emerging-concept-encompassing-various-inflammatory-keratinization-disorders-of-the-skin
#20
Masashi Akiyama, Takuya Takeichi, John A McGrath, Kazumitsu Sugiura
Classifying inflammatory skin diseases is challenging, especially for the expanding group of disorders triggered by genetic factors resulting in hyperactivated innate immunity that result in overlapping patterns of dermal and epidermal inflammation with hyperkeratosis. For such conditions, the umbrella term "autoinflammatory keratinization diseases" (AIKD) has been proposed. AIKD encompasses diseases with mixed pathomechanisms of autoinflammation and autoimmunity, and includes IL-36 receptor antagonist (IL-36Ra)-related pustulosis, CARD14-mediated pustular psoriasis, pityriasis rubra pilaris (PRP) type V, and familial keratosis lichenoides chronica (KLC)...
February 1, 2018: Journal of Dermatological Science
keyword
keyword
59815
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"