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Keratin

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https://www.readbyqxmd.com/read/28821199/keratin-17-is-a-prognostic-biomarker-in-endocervical-glandular-neoplasia
#1
Daniel Mockler, Luisa F Escobar-Hoyos, Ali Akalin, Jamie Romeiser, A Laurie Shroyer, Kenneth R Shroyer
Objectives: Previous work in our laboratory identified keratin 17 (K17) as a specific and sensitive biomarker for high-grade squamous intraepithelial lesions and cervical squamous cell carcinoma (SCC). K17, however, has not been previously evaluated in endocervical glandular neoplasia. Based on the similar pathogenesis of squamous and glandular lesions of the cervix, we hypothesized that K17 overexpression could also be a diagnostic and/or prognostic biomarker for endocervical neoplasia...
September 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28820163/sympathetic-ophthalmia-related-to-conjunctival-invasive-squamous-cell-carcinoma
#2
In S Leal, David Cordeiro Sousa, Cláudia Loureiro, Ana Fonseca
Sympathetic ophthalmia (SO) is a rare, diffuse, bilateral, and granulomatous nonnecrotizing panuveitis that may follow intraocular penetrating trauma. Our aim is to report a rare case of SO following orbital exenteration. Orbital exenteration was performed on a 48-year-old african female due to conjunctival keratinizing squamous cell carcinoma with intraocular involvement of the left eye. Five days after the uneventful procedure, the patient presented signs and symptoms compatible with SO. Key differential diagnoses were excluded, and prompt and aggressive immunosuppression was started with a favourable but slow clinical response...
August 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28817957/case-report-of-onychomycosis-and-tinea-corporis-due-to-microsporum-gypseum
#3
Jesse M Fike, Ramya Kollipara, Suzanne Alkul, Cloyce L Stetson
BACKGROUND: Microsporum gypseum is a geophilic dermatophyte that colonises keratinous substances in the soil. Fur-bearing animals carry this dermatophyte but are rarely infected. Human infection can be acquired from the soil, carrier or infected animals, and rarely other humans. M gypseum is an uncommon cause of cutaneous infection in humans and typically manifests as tinea corporis, tinea barbae, and tinea capitis. Onychomycosis is rarely caused by M gypseum. CASE SUMMARY: We present a case of a 32-year-old white man who presented with a red scaly rash and nail dystrophy after adopting a pet rat 10 years prior to presentation...
August 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28817832/successful-use-of-grenz-rays-for-disseminated-superficial-actinic-porokeratosis-report-of-8-cases
#4
Egle Ramelyte, Matilda Bylaite-Bucinskiene, Reinhard Dummer, Laurence Imhof
BACKGROUND: Disseminated superficial actinic porokeratosis (DSAP) is a rare keratinization disorder with potential malignant transformation, for which present treatment strategies show limited success. AIM: To evaluate the response of DSAP lesions to grenz ray radiotherapy (RTx). METHODS: Data of patients treated with RTx at University Hospital Zurich, Switzerland, between 2004 and 2015, were reviewed. Patients with DSAP, who received at least 1 RTx treatment session and who had been followed up for at least 4 weeks were included in the further data analysis...
August 18, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28817352/arhgap29-mutation-is-associated-with-abnormal-oral-epithelial-adhesions
#5
B J Paul, K Palmer, J C Sharp, C H Pratt, S A Murray, M Dunnwald
Nonsyndromic cleft lip and/or palate (NSCL/P) is a prevalent birth defect of complex etiology. Previous studies identified mutations in ARHGAP29 associated with an increased risk for NSCL/P. To investigate the effects of ARHGAP29 in vivo, we generated a novel murine allele by inserting a point mutation identified in a patient with NSCL/P. This single-nucleotide variation of ARHGAP29 translates to an early nonsense mutation (K326X), presumably resulting in loss-of-function (LoF). Embryos from Arhgap29(K326X/+) intercrosses were harvested at various time points...
August 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28817140/relationship-between-clinical-and-histologic-periodontal-biotypes-in-humans
#6
Sergio Henrique Gonçalves Motta, Marcos Paulo Ferreira Camacho, Danielle Carvalho Quintela, Ronaldo B Santana
Histologic and histomorphometric evaluations of gingival biopsy samples of patients presenting either a thick or a thin gingival biotype were performed. Full-thickness gingival biopsy samples were obtained and processed for histologic and histometric evaluations. Thickness of the keratinized mucosa or gingiva was found to be increased in the thick biotype. Specifically, the connective tissue layer was thicker with no change in epithelial thickness. In conclusion, gingival transparency appears to be an adequate, clinically useful method to classify the gingival biotype...
September 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28817130/the-use-of-autogenous-gingival-graft-for-treatment-of-lingual-recession-on-mandibular-anterior-teeth
#7
Gonçalo Assis, Myron Nevins, David M Kim
The goal of this article is to demonstrate the practicality and results of increasing the zone of keratinized tissue on the lingual surface of mandibular anterior teeth via case reports. Calculus is most commonly found on the lingual surface of these teeth, so they are subjected to inflammatory elements resulting in tissue deformation and destruction. Significant attention has been paid to grafting the buccal surface, but there is a paucity of information addressing the lingual surface of mandibular anterior teeth...
September 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28815579/-histological-characteristics-of-hpv-associated-and-independent-squamous-cell-carcinomas-of-the-vulva-a-study-of-1594-cases
#8
Natalia Rakislova, Omar Clavero, Laia Alemany, Adela Saco, Beatriz Quirós, Belen Lloveras, Maria Alejo, Michael Pawlita, Wim Quint, Marta Del Pino, Silvia de Sanjose, Jaume Ordi
There are at least two different etio-pathogenic pathways for the development of vulvar squamous cell carcinoma (VSCC): one associated with infection by human papillomavirus (HPV) and another independent of HPV. We aimed to describe the histological characteristics of HPV-associated and HPV-independent tumors and to determine the best strategy to identify HPV in VSCC. A single paraffin block was available for review from a series of 1594 VSCCs. In all cases HPV DNA detection was analyzed using the SPF10PCR/DEIA/LiPA25 system and p16 immunohistochemistry (IHC)...
August 17, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28810650/glutathione-s-transferase-a1-mediates-nicotine-induced-lung-cancer-cell-metastasis-by-promoting-epithelial-mesenchymal-transition
#9
Wei Wang, Feiyu Liu, Chaoyang Wang, Chengde Wang, Yijun Tang, Zhongmin Jiang
The present study aimed to investigate the effect of glutathione S-transferase A1 (GSTA1) on lung cancer cell viability, invasion and adhesion in the presence of nicotine in vitro. Furthermore, the effect of GSTA1 on the epithelial-mesenchymal transition (EMT), a process strongly associated with lung cancer metastasis, was examined. Human lung carcinoma A549 cells were treated with various concentrations of nicotine (0.01, 0.1, 1 and 10 µM) and levels of GSTA1 mRNA and protein were measured by reverse transcription-quantitative polymerase chain reaction and western blot analysis, respectively...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28809375/clinical-parameters-of-implants-placed-in-healed-sites-using-flapped-and-flapless-techniques-a-systematic-review
#10
O Llamas-Monteagudo, P Girbés-Ballester, J Viña-Almunia, D Peñarrocha-Oltra, M Peñarrocha-Diago
BACKGROUND: Dental implant placement using flapless surgery is a minimally invasive technique that improves blood supply compared with flapped surgery. However, the flapless technique does not provide access to allow bone regeneration. OBJECTIVE: The aim of this systematic review was to evaluate the clinical parameters following implant surgery in healed sites, using two procedures: flapped vs. flapless surgery. MATERIALS AND METHODS: A detailed electronic search was carried out in the PubMed/Medline, Embase and Cochrane Library databases...
August 15, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28808929/high-expression-of-ho-1-predicts-poor-prognosis-of-ovarian-cancer-patients-and-promotes-proliferation-and-aggressiveness-of-ovarian-cancer-cells
#11
Z Zhao, Y Xu, J Lu, J Xue, P Liu
PURPOSE: HO-1 has been proved to be associated with tumor aggressivity and poor prognosis in various cancers. Our study provides the first study to demonstrate the relationship of HO-1 expression and clinical characteristics in ovarian cancer patients. METHODS: Immunohistochemistry and western blotting were used to examine the expression of HO-1 in tissue species and fresh tissues. CCK-8 was used to investigate cell viability. Transwell chamber was performed to estimate migration and invasion capacities in A2780 and Skov-3 cells...
August 14, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28808357/platelet-released-growth-factors-induce-differentiation-of-primary-keratinocytes
#12
Andreas Bayer, Mersedeh Tohidnezhad, Justus Lammel, Sebastian Lippross, Peter Behrendt, Tim Klüter, Thomas Pufe, Holger Jahr, Jochen Cremer, Franziska Rademacher, Regine Gläser, Jürgen Harder
Autologous thrombocyte concentrate lysates, for example, platelet-released growth factors, (PRGFs) or their clinically related formulations (e.g., Vivostat PRF®) came recently into the physicians' focus as they revealed promising effects in regenerative and reparative medicine such as the support of healing of chronic wounds. To elucidate the underlying mechanisms, we analyzed the influence of PRGF and Vivostat PRF on human keratinocyte differentiation in vitro and on epidermal differentiation status of skin wounds in vivo...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28806646/static-flexural-properties-of-hedgehog-spines-conditioned-in-coupled-temperature-and-relative-humidity-environments
#13
Emily B Kennedy, Bor-Kai Hsiung, Nathan B Swift, Kwek-Tze Tan
Hedgehogs are agile climbers, scaling trees and plants to heights exceeding 10m while foraging insects. Hedgehog spines (a.k.a. quills) provide fall protection by absorbing shock and could offer insights for the design of lightweight, material-efficient, impact-resistant structures. There has been some study of flexural properties of hedgehog spines, but an understanding of how this keratinous biological material is affected by various temperature and relative humidity treatments, or how spine color (multicolored vs...
August 5, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28805938/what-is-new-in-the-pathophysiology-of-acne-an-overview
#14
REVIEW
B Dréno
Acne is a chronic inflammatory disease of the pilosebaceous unit. Its pathophysiology includes hyperseborrhoea, abnormal follicular keratinization and Propionibacterium acnes proliferation in the pilosebaceous unit. Recent research has shed some new light on the involvement of the sebaceous gland, as well as on the pro-inflammatory activity of the cutaneous microbiome. During puberty, alteration of the sebaceous lipid profile, called dysseborrhoea, stress, irritation, cosmetics and potential dietary factors lead to inflammation and formation of different types of acne lesions...
September 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28801097/chicken-feathers-as-a-natural-source-of-sulphur-to-develop-sustainable-protein-films-with-enhanced-properties
#15
Tania Garrido, Itsaso Leceta, Koro de la Caba, Pedro Guerrero
In this work, the effect of hydrolyzed keratin on the properties of soy protein-based films was analyzed when different manufacture processes were employed. It is widely known that the processing method selected can affect the film properties as a function of the structure obtained during the film formation. Therefore, the assessment of hydrolyzed keratin/soy protein films processed by casting and compression moulding was carried out by means of the analysis of physicochemical, thermal, mechanical, optical and surface properties...
August 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28796987/evaluation-of-periodontal-tissues-in-growing-patients-with-bilateral-cleft-lip-and-palate-a-pilot-study
#16
Beata Wyrębek, Dorota Cudziło, Paweł Plakwicz
AIM: To evaluate the periodontal status, mucogingival parameters and oral hygiene in growing patients with bilateral cleft lip and palate. MATERIAL AND METHODS: Assessment was performed in 15 patients aged 6 to 18 years with a bilateral cleft. Records included probing pocket depth, clinical attachment level, keratinized gingiva, recession, vestibule depth, biotype, type of fraena, dental plaque and bleeding. RESULTS: The mean scores of pocket depth were: 1...
2017: Developmental Period Medicine
https://www.readbyqxmd.com/read/28794569/cortisol-homeostasis-in-the-epidermis-is-influenced-by-topical-corticosteroids-in-patients-with-atopic-dermatitis
#17
Mototsugu Fukaya
BACKGROUND: The skin produces cortisol by itself and regulates its own proliferation and differentiation. There is a possibility that topical corticosteroids (TCSs) influence the cortisol homeostasis in the skin. AIMS AND OBJECTIVES: The author described the density and distribution of cortisol and its parties in the epidermis after application of topical steroids immunohistologically. MATERIALS AND METHODS: The forearm skin was biopsied before and after 2 weeks' application of clobetasol propionate 0...
July 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28794556/keratin-17-mutations-in-four-families-from-india-with-pachyonychia-congenita
#18
Manoj Agarwala, Pankaj Salphale, Dincy Peter, Neil J Wilson, Susanne Pulimood, Mary E Schwartz, Frances J D Smith
Pachyonychia congenita (PC) is a rare autosomal dominant genetic skin disorder due to a mutation in any one of the five keratin genes, KRT6A, KRT6B, KRT6C, KRT16, or KRT17. The main features are palmoplantar keratoderma, plantar pain, and nail dystrophy. Cysts of various types, follicular hyperkeratosis, oral leukokeratosis, hyperhidrosis, and natal teeth may also be present. Four unrelated Indian families presented with a clinical diagnosis of PC. This was confirmed by genetic testing; mutations in KRT17 were identified in all affected individuals...
July 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28794543/synchronizing-pharmacotherapy-in-acne-with-review-of-clinical-care
#19
REVIEW
Sarvajnamurthy Aradhya Sacchidanand, Koushik Lahiri, Kiran Godse, Narendra Gajanan Patwardhan, Anil Ganjoo, Rajendra Kharkar, Varsha Narayanan, Dhammraj Borade, Lyndon D'souza
Acne is a chronic inflammatory skin disease that involves the pathogenesis of four major factors, such as androgen-induced increased sebum secretion, altered keratinization, colonization of Propionibacterium acnes, and inflammation. Several acne mono-treatment and combination treatment regimens are available and prescribed in the Indian market, ranging from retinoids, benzoyl peroxide (BPO), anti-infectives, and other miscellaneous agents. Although standard guidelines and recommendations overview the management of mild, moderate, and severe acne, relevance and positioning of each category of pharmacotherapy available in Indian market are still unexplained...
July 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28790852/impact-of-combined-treatment-with-nimesulide-and-cisplatin-on-oral-carcinoma-cells
#20
Aleksandra Barac, Goran Mitulovic, Seth Hallström, Sonja Zehetmayer, Matthaeus Ch Grasl, Boban M Erovic
BACKGROUND: Despite significant advances in diagnosis and therapy, the rate of survival of patients with oral cancers still remains poor as an appropriate treatment has not been found yet, due to side effects of chemo/radiotherapy. AIM: This study aimed to identify molecular mechanisms of cell death of oral cancer cells caused by treatment with a nonselective Cox-2 inhibitor in combination with a low-dose chemotherapeutic drug. METHODS: Squamous cell carcinoma (SCC) cells SCC9 and SCC25 were subjected to mono- and combination therapy with nimesulide and cisplatin...
2017: OncoTargets and Therapy
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