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https://www.readbyqxmd.com/read/29770232/long-term-follow-up-of-adamantinoma-of-the-tibia-complicated-by-metastases-and-a-second-unrelated-primary-cancer-a-case-report-and-literature-review
#1
Brendan R Southam, Alvin H Crawford, David A Billmire, James Geller, Daniel Von Allmen, Adam P Schumaier, Sara Szabo
Adamantinoma is a rare, low-grade malignant tumor of the bone which grows slowly and typically occurs in the diaphysis of long bones, particularly in the tibia. Adamantinomas have the potential for local recurrence and may metastasize to the lungs, lymph nodes, or bone. We report a case of a 14-year-old female with a tibial adamantinoma who underwent wide resection with limb salvage and has subsequently been followed up for 18 years. The patient went on to have both a local soft tissue recurrence 5 years after the resection and metastases to both an inguinal lymph node and the right lower lobe of the lung 8 years after that recurrence, all of which have been treated successfully with marginal resections...
2018: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29768641/-the-role-of-elective-neck-dissection-during-salvage-laryngectomy-a-retrospective-analysis
#2
Timon Hussain, Oliver Kanaan, Benedikt Höing, Nina Dominas, Stephan Lang, Stefan Mattheis
Elective neck dissection of the N0-neck is routinely performed during salvage laryngectomy (SLE) for recurrent cancer of the larynx or hypopharynx. The therapeutic benefit of additional neck dissection must be weighed against the risk of increased morbidity. In this retrospective analysis, we assessed oncologic parameters of patients who underwent SLE with concurrent bilateral neck dissection for recurrent laryngeal or hypopharyngeal cancer. We compared these data with patients who underwent primary laryngectomy (LE) with bilateral neck dissection for laryngeal and hypopharyngeal cancer...
May 16, 2018: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29759332/sunset-stereotactic-radiation-for-ultracentral-non-small-cell-lung-cancer-a-safety-and-efficacy-trial
#3
Meredith Giuliani, Ashwathy S Mathew, Houda Bahig, Scott V Bratman, Edith Filion, Daniel Glick, Alexander V Louie, Srinivas Raman, Anand Swaminath, Andrew Warner, Vivian Yau, David Palma
BACKGROUND: Lung stereotactic body radiotherapy (SBRT) is considered a standard curative treatment for medically inoperable early stage non-small-cell lung cancer (NSCLC). Patients with ultracentral tumors (signifying tumors whose planning target volume touches or overlaps the central bronchial tree, esophagus, or pulmonary artery) may be at higher risk of serious toxicities such as bronchial stricture and collapse, esophageal strictures, tracheal-esophageal fistula, and hemorrhage. The primary objective of the study is to determine the maximum tolerated dose of radiotherapy for ultracentral NSCLC...
April 18, 2018: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29755071/-salvage-surgery-after-radical-chemotherapy-for-n3-non-small-cell-lung-cancer
#4
Takehiko Shimoyama, Bumpei Kimura
A 49-year-old man was admitted to our hospital for an abnormal chest shadow. Computed tomography showed a pulmonary nodular shadow in the right upper lobe and swelling of the right hilar, mediastinal and supraclavicular lymph nodes. A positron emission tomography(PET) scan showed fluorodeoxyglucose accumulation in the tumor and swollen lymph nodes. He was diagnosed with stage cT1aN3M0 (ⅢB) pulmonary adenocarcinoma and was treated with a combination of cisplatin and paclitaxel. After 6 cycles of chemotherapy, serum carcinoembryonic antigen (CEA) level was markedly decreased...
March 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29740586/supermicrosurgery-history-applications-training-and-the-future
#5
Ido Badash, Daniel J Gould, Ketan M Patel
Supermicrosurgery, a technique of dissection and anastomosis of small vessels ranging from 0.3 to 0.8 mm, has revolutionized the fields of lymphedema treatment and soft tissue reconstruction. The technique offers several distinct benefits to microsurgeons, including the ability to manipulate small vessels that were previously inaccessible, and to minimize donor-site morbidity by dissecting short pedicles in a suprafascial plane. Thus, supermicrosurgery has become increasingly popular in recent years, and its applications have greatly expanded since it was first introduced 20 years ago...
2018: Frontiers in Surgery
https://www.readbyqxmd.com/read/29719816/local-and-regional-breast-cancer-recurrences-salvage-therapy-options-in-the-new-era-of-molecular-subtypes
#6
REVIEW
Yazid Belkacemi, Nivin E Hanna, Clementine Besnard, Soufya Majdoul, Joseph Gligorov
Isolated local or regional recurrence of breast cancer (BC) leads to an increased risk of metastases and decreased survival. Ipsilateral breast recurrence can occur at the initial tumor bed or in another quadrant of the breast. Depending on tumor patterns and molecular subtypes, the risk and time to onset of metastatic recurrence differs. HER2-positive and triple-negative (TNG) BC have a risk of locoregional relapse between six and eight times than luminal A. Thus, the management of local and locoregional relapses must take into account the prognostic factors for metastatic disease development...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29705139/characteristics-treatment-decisions-and-outcomes-of-prepubertal-testicular-germ-cell-tumor-a-descriptive-analysis-from-a-large-chinese-center
#7
P Liu, W Li, H C Song, L L Jiao, W P Zhang, N Sun
INTRODUCTION: Prepubertal testicular tumors are fundamentally distinct from their postpubertal and adult counterparts. Racial and ethnic differences contribute to the incidence, characteristics, and histological distribution of prepubertal testicular germ cell tumors (PTGCTs). OBJECTIVE: To elucidate the characteristics and treatment outcomes of PTGCTs in a Chinese cohort. STUDY DESIGN: Data were retrospectively reviewed from consecutive PTGCT patients aged <12 years who received treatment at the current institution from January 2007 to December 2015...
April 3, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29693799/evaluation-of-boost-irradiation-in-patients-with-intermediate-risk-stage-iii-wilms-tumour-with-positive-lymph-nodes-only-results-from-the-siop-wt-2001-registry
#8
Raquel Dávila Fajardo, Eva Oldenburger, Christian Rübe, Marta López-Yurda, Kathy Pritchard-Jones, Christophe Bergeron, Norbert Graf, Martine van Grotel, Harm van Tinteren, Daniel Saunders, Marry M van den Heuvel-Eibrink, Geert O Janssens, Foppe Oldenburger
OBJECTIVE: To evaluate the value of radiotherapy boost omission in patients with intermediate-risk, stage III Wilms tumours (WT) with positive lymph nodes (LN). METHODS AND MATERIALS: All patients with intermediate-risk, stage III (LN positive) WT consecutively registered in the SIOP-WT-2001 study were included in this analysis. Endpoints were 5-year event-free survival (EFS), loco-regional control (LRC) and overall survival (OS). RESULTS: Between June 2001 and May 2015, 2,569 patients with stage I to III WT after preoperative chemotherapy were registered in the SIOP-WT-2001 study...
April 25, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29691737/salvage-abdominoperineal-resection-for-squamous-cell-anal-cancer-a-30-year-single-institution-experience
#9
J A W Hagemans, S E Blinde, J J Nuyttens, W G Morshuis, M A M Mureau, J Rothbarth, C Verhoef, J W A Burger
BACKGROUND: Failure of chemoradiotherapy (CRT) for anal squamous cell carcinoma (SCC) results in persistent or recurrent anal SCC. Treatment with salvage abdominoperineal resection (APR) can potentially achieve cure. The aims of this study are to analyze oncological and surgical outcomes of our 30-year experience with salvage APR for anal SCC after failed CRT and identify prognostic factors for overall survival (OS). METHODS: All consecutive patients who underwent salvage APR between 1990 and 2016 for histologically confirmed persistent or recurrent anal SCC after failed CRT were retrospectively analyzed...
April 24, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29682612/salvage-pelvic-lymph-node-dissection-after-fluciclovine-positron-emission-tomography-computed-tomography-detected-prostate-cancer-recurrence
#10
Madeline Cancian, Jorge Pereira, Joseph F Renzulli
Background: Multiple new systemic agents have been targeted to metastatic prostate cancer, with decreased progression of disease but no cure. Surgical management of metastatic disease has been gaining interest, primarily in the setting of high-risk prostatectomies. However, metastasis-directed surgical intervention has been employed in rare scenarios, especially in oligometastatic disease. We report here on a salvage robot-assisted pelvic lymph node dissection for a solitary metastatic site. Case Presentation: A 63-year-old Hispanic man who was initially treated with prostatectomy for intermediate risk cancer developed rapid biochemical recurrence...
2018: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/29650851/-a-case-of-isolated-lateral-pelvic-lymph-node-recurrence-after-tme-for-early-lower-rectal-cancer-treated-with-laparoscopic-lateral-lymph-node-dissection
#11
Ryuichiro Kimura, Masayoshi Yasui, Masayuki Ohue, Yusuke Takahashi, Norikatsu Miyoshi, Yoshitomo Yanagimoto, Keijiro Sugimura, Akira Tomokuni, Hirofumi Akita, Moon Jeong-Ho, Shogo Kobayashi, Hidenori Takahashi, Takeshi Omori, Yoshiyuki Fujiwara, Hiroshi Miyata, Masahiko Yano, Masato Sakon
There are no established treatment protocol for isolated lateral lymph node recurrence in patients with T1 lower rectal cancer, because such case is very rare. In our institution, this is the only recorded case of lateral node recurrence post-resection. It has been documented in several studies that salvage surgery for colorectal cancer improves prognosis. However, there were only 3 reported cases found for lateral lymph node metastasis from colorectal cancer that underwent excision. In this study, we report a rare case of lateral lymph node recurrence after trans-anal resection for T1 lower rectal cancer wherein we performed laparoscopic right lateral pelvic lymph node dissection...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29642326/re-robotic-salvage-retroperitoneal-and-pelvic-lymph-node-dissection-for-node-only-recurrent-prostate-cancer-technique-and-initial-series
#12
Jeffrey A Cadeddu
No abstract text is available yet for this article.
April 2018: Journal of Urology
https://www.readbyqxmd.com/read/29625782/lymph-node-yield-during-radical-prostatectomy-does-not-impact-rate-of-biochemical-recurrence-in-patients-with-seminal-vesicle-invasion-and-node-negative-disease
#13
Ketan K Badani, Balaji N Reddy, Eric J Moskowitz, David J Paulucci, Alp Tuna Beksac, Alberto Martini, Michael J Whalen, Douglas W Skarecky, Linda My Huynh, Thomas E Ahlering
OBJECTIVES: Seminal vesicle invasion (SVI) is a risk factor for poor oncologic outcome in patients with prostate cancer. Modifications to the pelvic lymph node dissection (PLND) during radical prostatectomy (RP) have been reported to have a therapeutic benefit. The present study is the first to determine if lymph node yield (LNY) is associated with a lower risk of biochemical recurrence (BCR) for men with SVI. METHODS: A total of 220 patients from 2 high-volume institutions who underwent RP without adjuvant treatment between 1990 and 2015 and had prostate cancer with SVI (i...
April 3, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29616296/psma-pet-guided-hook-wire-localization-of-nodal-metastases-in-prostate-cancer-a-targeted-approach
#14
REVIEW
Emma Clarebrough, Catriona Duncan, Daniel Christidis, Alain Lavoipierre, Nathan Lawrentschuk
Prostate Specific Membrane Antigen Positron Emission Tomography/Computed Tomography (PSMA-PET/CT) has increased the sensitivity and specificity of imaging to identify metastatic prostate cancer in the group of patients with early biochemical recurrence when compared to conventional imaging. In patients who develop biochemical recurrence of prostate cancer following surgical resection, salvage lymph node dissection may reduce prostate specific antigen (PSA) levels and delay the time for commencement of systemic therapies...
April 3, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29571347/salvage-pulmonary-metastasectomy-for-local-relapse-after-stereotactic-body-radiotherapy
#15
Masatsugu Hamaji, Takamasa Mitsuyoshi, Akihiko Yoshizawa, Toshihiko Sato, Yukinori Matsuo, Toyofumi-Fengshi Chen-Yoshikawa, Makoto Sonobe, Takashi Mizowaki, Hiroshi Date
Although several studies have evaluated the local control and survival outcomes in patients undergoing stereotactic body radiotherapy (SBRT) for pulmonary oligometastases, little data are available on the management of local relapse. Here, we present 3 patients who underwent lobectomy and mediastinal lymph node dissection as salvage pulmonary metastasectomy for local relapse after SBRT. The postoperative course has been uneventful for all 3 patients, with no evidence of disease at 40, 51, and 6 months from the salvage metastasectomy...
April 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29544737/more-extensive-lymph-node-dissection-at-radical-prostatectomy-is-associated-with-improved-outcomes-with-salvage-radiotherapy-for-rising-prostate-specific-antigen-after-surgery-a-long-term-multi-institutional-analysis
#16
Nicola Fossati, William P Parker, R Jeffrey Karnes, Michele Colicchia, Alberto Bossi, Thomas Seisen, Nadia Di Muzio, Cesare Cozzarini, Barbara Noris Chiorda, Claudio Fiorino, Giorgio Gandaglia, Detlef Bartkowiak, Thomas Wiegel, Shahrokh Shariat, Gregor Goldner, Antonino Battaglia, Steven Joniau, Karin Haustermans, Gert De Meerleer, Valérie Fonteyne, Piet Ost, Hein Van Poppel, Francesco Montorsi, Alberto Briganti, Stephen A Boorjian
Up to 50% of patients recur after salvage radiation therapy (sRT) for prostate-specific antigen (PSA) rise following radical prostatectomy (RP). Notably, the importance of lymph node dissection (LND) at the time of RP with regard to recurrence risk following sRT has not been previously determined. Therefore, we evaluated the association between nodal yield at RP and recurrence after sRT. We performed a multi-institutional review of men with a rising PSA after RP treated with sRT. Clinicopathologic variables were abstracted, and the associations between lymph node yield and biochemical (BCR) as well as clinical recurrence (CR) after sRT were assessed using multivariable Cox proportional hazards regression models...
March 12, 2018: European Urology
https://www.readbyqxmd.com/read/29530632/standard-of-care-versus-metastases-directed-therapy-for-pet-detected-nodal-oligorecurrent-prostate-cancer-following-multimodality-treatment-a-multi-institutional-case-control-study
#17
T Steuber, C Jilg, P Tennstedt, A De Bruycker, D Tilki, K Decaestecker, T Zilli, B A Jereczek-Fossa, U Wetterauer, A L Grosu, W Schultze-Seemann, H Heinzer, M Graefen, A Morlacco, R J Karnes, P Ost
BACKGROUND: Most prostate cancer (PCa) patients with a biochemical failure following primary multimodality treatment (surgery and postoperative radiotherapy) relapse in the nodes. OBJECTIVE: To perform a matched-case analysis in men with lymph node recurrent PCa comparing standard of care (SOC) with metastasis-directed therapy (MDT). DESIGN, SETTING, AND PARTICIPANTS: PCa patients with a prostate-specific antigen (PSA) progression following multimodality treatment were included in this retrospective multi-institutional analysis...
March 10, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29529647/synovial-sarcoma-is-not-associated-with-a-higher-risk-of-lymph-node-metastasis-compared-with-other-soft-tissue-sarcomas
#18
Andrew J Jacobs, Carol D Morris, Adam S Levin
BACKGROUND: Reported rates of the incidence of lymph node metastasis in soft tissue sarcoma vary considerably. Many are based on single-institution series and small patient populations. Certain sarcoma subtypes, including synovial sarcoma, have been associated with a higher risk of lymph node involvement. Most single centers have insufficient numbers of patients to assess lymph node metastasis accurately, but larger national databases may allow a more accurate estimation. QUESTIONS/PURPOSES: We queried a large national database and asked the following questions: (1) What proportion of patients with soft tissue sarcoma have lymph node metastasis and distant metastasis? (2) What histologic subtypes are associated with increased risk of nodal metastasis? (3) What is the impact of lymph node metastases and histologic subtype on survival? (4) Does lymph node excision improve survival of patients with soft tissue sarcoma? METHODS: The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program is a national database that covers a geographic cross-section representing approximately 28% of the US population across demographic groups...
March 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29520383/can-pelvic-node-dissection-at-radical-prostatectomy-influence-the-nodal-recurrence-at-salvage-lymphadenectomy-for-prostate-cancer
#19
Arjun Sivaraman, Nicole Benfante, Karim Touijer, Jonathan Coleman, Peter Scardino, Vincent Laudone, James Eastham
Purpose: To verify the quality of pelvic lymph node dissection (PLND) performed at radical prostatectomy (RP) and its impact on nodal recurrence in patients undergoing salvage lymph node dissection (sLND). Materials and Methods: Retrospective review of 48 patients who underwent sLND for presumed nodal recurrence, to describe the PLND characteristics at RP and correlate the anatomical sites and number of suspicious nodes reported in radiological imaging and final pathology of sLND...
March 2018: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29504654/de-novo-neurogenic-bladder-dysfunction-after-salvage-lymph-node-dissection-in-patients-with-nodal-recurrence-of-prostate-cancer
#20
Julian Hanske, Guido Müller, Arndt van Ophoven, Nicolas von Landenberg, Florian Roghmann, Rein-Jüri Palisaar, Christian von Bodman, Joachim Noldus, Marko Brock
AIMS: To examine the impact of Salvage lymph node dissection (SLND) on bladder function and oncological outcome in hormone naïve patients with nodal recurrence of prostate cancer (PCa) after radical prostatectomy (RP). METHODS: In a prospective study between October 2015 and November 2016, 20 patients underwent transperitoneal SLND for nodal recurrence of PCa after RP at our institution. Standardized urodynamics were performed pre- and postoperatively after 6 weeks, 3, and 6 to 12 months...
March 5, 2018: Neurourology and Urodynamics
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