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https://www.readbyqxmd.com/read/29338978/non-risk-adapted-surveillance-for-stage-i-testicular-cancer-critical-review-and-summary
#1
REVIEW
Phillip Martin Pierorazio, Peter Albers, Peter C Black, Torgrim Tandstad, Axel Heidenreich, Nicola Nicolai, Craig Nichols
CONTEXT: Cancer-specific survival for men with clinical stage I testicular cancer (CSITC) is uniformly excellent. Non-risk-adapted active surveillance (NRAS) is a management strategy for CSITC to minimize overtreatment and avoid possible long-term side effects of adjuvant therapy. OBJECTIVE: To review the evidence regarding oncologic outcomes for men with CSITC undergoing NRAS and discuss ongoing controversies in the management of CSITC. EVIDENCE ACQUISITION: MEDLINE/PubMed, Embase, and the Cochrane Central Register of Controlled Trials were searched from January 1, 1987 through January 1, 2017...
January 12, 2018: European Urology
https://www.readbyqxmd.com/read/29245340/successful-salvage-for-the-intractable-massive-chylous-leakage-in-a-cirrhotic-patient-a-case-report-and-literature-review
#2
Chun-Lin Su, Geng-He Chang, Ku-Hao Fang, Chang-Cheng Chang
RATIONALE: Iatrogenic chylous leakage (CL) is a rare but potentially life-threatening complication after neck surgery. In cirrhotic patient, the massive CL is even more intractable and extremely dangerous due to portal hypertension. PATIENTS CONCERNS: A 54-year-old liver cirrhotic patient had milky fluid leakage from left neck drainage tube after neck dissection surgery and hypopharyngeal cancer ablation. Electrolyte imbalance and shock status were reported when conservative managements and exploratory surgical repair failed to terminate the leakage...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29227857/salvage-esophagectomy-with-pancreatectomy-for-local-recurrence-of-thoracic-esophageal-cancer-after-definitive-chemoradiotherapy-a-case-report
#3
Noriyuki Nishiwaki, Yasuhiro Tsubosa, Masahiro Niihara
INTRODUCTION: We encountered a case of advanced thoracic esophageal cancer in which R0 resection was achieved by salvage esophagectomy with pancreatectomy, but relapse occurred in the early postoperative phase. PRESENTATION OF CASE: A 64-year-old man with lower intrathoracic esophageal cancer received chemoradiotherapy, and a complete response was achieved. Subsequently, however, lymph node relapse, with infiltration into the pancreas, was observed. Thus, subtotal esophageal resection, total gastrectomy, distal pancreatectomy, and splenectomy were performed...
December 6, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29212973/-refractory-cd20-positive-peripheral-t-cell-lymphoma-showing-loss-of-cd20-expression-after-rituximab-therapy-and-gain-of-cd20-expression-after-administration-of-vorinostat-and-gemcitabine
#4
Kazuaki Teshima, Hideaki Ohyagi, Masaaki Kume, Satsuki Takahashi, Masahiro Saito, Naoto Takahashi
A 79-year-old male patient presented with systemic lymphadenopathy. A lymph node biopsy revealed effacement of the normal nodal architecture with diffuse proliferation of medium-sized atypical lymphoid cells. Southern blot analyses demonstrated rearrangement of the T-cell receptor gene but not the immunoglobulin heavy chain gene. He was diagnosed with CD20-positive peripheral T-cell lymphoma (PTCL), NOS. Although he achieved partial remission after six cycles of R-CHOP, he relapse occurred after 2 months. CD20-negative conversion was confirmed in the lymph node, which was positive for CCR4, and the skin at the time of relapse...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/29188197/68ga-prostate-specific-membrane-antigen-positron-emission-tomography-computed-tomography-in-advanced-prostate-cancer-current-state-and-future-trends
#5
REVIEW
Cristian Udovicich, Marlon Perera, Michael S Hofman, Shankar Siva, Andres Del Rio, Declan G Murphy, Nathan Lawrentschuk
The early and accurate detection of prostate cancer is important to ensure timely management and appropriate individualized treatment. Currently, conventional imaging has limitations particularly in the early detection of metastases and at prostate-specific antigen (PSA) levels < 2.0 ng/mL. Furthermore, disease management such as salvage radiotherapy is best at low PSA levels. Thus, it is critical to capture the disease in the oligometastatic stage as disease progression and commencement of systemic therapies can be delayed by metastasis-directed therapy...
December 2017: Prostate International
https://www.readbyqxmd.com/read/29184880/histopathologic-risk-factors-for-lymph-node-metastasis-in-patients-with-t1-colorectal-cancer
#6
Ryun Kyong Ha, Kyung Su Han, Dae Kyung Sohn, Byung Chang Kim, Chang Won Hong, Hee Jin Chang, Jong Hee Hyun, Min Jung Kim, Sung Chan Park, Jae Hwan Oh
Purpose: Evaluating the risk of lymph node metastasis (LNM) is critical for determining subsequent treatments following endoscopic resection of T1 colorectal cancer (CRC). This study analyzed histopathologic risk factors for LNM in patients with T1 CRC. Methods: This study involved 745 patients with T1 CRC who underwent endoscopic (n = 97) or surgical (n = 648) resection between January 2001 and December 2015 at the National Cancer Center, Korea. LNM in endoscopically resected patients, which could not be evaluated directly, was estimated indirectly based on follow-up results and histopathologic reports of salvage surgery...
November 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29169381/surgical-resection-of-advanced-non-small-cell-lung-cancer-after-a-response-to-egfr-tki-presentation-of-two-cases-and-a-literature-review
#7
Yoko Yamamoto, Ken Kodama, Tomohiro Maniwa, Masashi Takeda
BACKGROUND: The usefulness of residual tumor resection after epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) treatment remains unclear. We describe two patients who underwent residual tumor resection after responding to EGFR-TKIs for advanced non-small cell lung cancer (NSCLC) harboring EGFR gene mutations, along with a review of the literature. CASE PRESENTATION: The patient in Case 1 was a 72-year-old female non-smoker who was initially diagnosed with T2aN2M0, stage IIIA adenocarcinoma harboring an EGFR exon 21 L858R mutation...
November 23, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29139652/liposarcoma-of-the-spermatic-cord-%C3%A2-a-rare-pathological-entity
#8
Nikola Radović, Arianna Bizatzki, Rajka Turner
Liposarcoma of the spermatic cord is a very rare neoplasm with fewer than 200 cases recorded in world literature. This report describes a case of liposarcoma of the spermatic cord which developed after radical prostatectomy and salvage radiotherapy for prostate cancer treatment. Four years following surgical treatment of the primary neoplasm and one year following radiotherapy, the 67 –year –old patient was referred to the urology clinic for the emergence of a mass in the right hemiscrotum region. Ultrasonography revealed a homogenous isodense mass measuring 4...
March 2017: Collegium Antropologicum
https://www.readbyqxmd.com/read/29137414/salvage-lymph-node-dissection-after-68-ga-psma-or-18-f-fec-pet-ct-for-nodal-recurrence-in-prostate-cancer-patients
#9
Annika Herlemann, Alexander Kretschmer, Alexander Buchner, Alexander Karl, Stefan Tritschler, Lina El-Malazi, Wolfgang P Fendler, Vera Wenter, Harun Ilhan, Peter Bartenstein, Christian G Stief, Christian Gratzke
The management of patients with biochemical recurrence (BCR) after definitive treatment for prostate cancer remains controversial. Our aim was to determine survival rates and complications of salvage lymph node dissection (sLND) in patients with recurrent prostate cancer after radical prostatectomy, while evaluating biochemical response (BR) with two different positron emission tomography/computed tomography (PET/CT) tracers used for preoperative imaging. sLND was performed in 104 patients diagnosed with isolated nodal recurrence on either (18)F-fluoroethylcholine ((18)F-FEC) or (68)Ga-PSMA-HBED-CC ((68)Ga-PSMA) PET/CT...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29134231/patterns-of-relapse-as-determined-by-68-ga-psma-ligand-pet-ct-after-radical-prostatectomy-importance-for-tailoring-and-individualizing-treatment
#10
Christoph Henkenberens, Thorsten Derlin, Frank M Bengel, Tobias L Ross, Hans-Jürgen Wester, Katja Hueper, Markus A Kuczyk, Hans Christiansen, Christoph A von Klot
PURPOSE: To evaluate the patterns of relapse and impact on the intended treatment when using (68)Ga-prostate-specific membrane antigen (PSMA) ligand positron emission tomography/computed tomography (PET/CT) imaging for restaging of disease in patients with biochemical relapse after radical prostatectomy (RP) before salvage radiotherapy (sRT). METHODS: In all, 39 patients with biochemical recurrence after RP who had no primary indication for adjuvant RT due to the absence of biologically unfavorable disease (e...
November 13, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29128208/multi-institutional-evaluation-of-elective-nodal-irradiation-and-or-androgen-deprivation-therapy-with-postprostatectomy-salvage-radiotherapy-for-prostate-cancer
#11
Stephen J Ramey, Shree Agrawal, Matthew C Abramowitz, Drew Moghanaki, Thomas M Pisansky, Jason A Efstathiou, Jeff M Michalski, Daniel E Spratt, Jason W D Hearn, Bridget F Koontz, Stanley L Liauw, Alan Pollack, Mitchell S Anscher, Robert B Den, Kevin L Stephans, Anthony L Zietman, W Robert Lee, Andrew J Stephenson, Rahul D Tendulkar
BACKGROUND: Outcomes with postprostatectomy salvage radiation therapy (SRT) are not ideal. Little evidence exists regarding potential benefits of adding whole pelvic radiation therapy (WPRT) alone or in combination with androgen deprivation therapy (ADT). OBJECTIVE: To explore whether WPRT and/or ADT added to prostate bed radiation therapy (PBRT) improves freedom from biochemical failure (FFBF) or distant metastases (DM). DESIGN, SETTING, AND PARTICIPANTS: A database was compiled from 10 academic institutions of patients with postprostatectomy prostate-specific antigen (PSA) >0...
November 8, 2017: European Urology
https://www.readbyqxmd.com/read/29126446/detection-level-and-pattern-of-positive-lesions-using-psma-pet-ct-for-staging-prior-to-radiation-therapy
#12
Nina-Sophie Schmidt-Hegemann, Wolfgang Peter Fendler, Alexander Buchner, Christian Stief, Paul Rogowski, Maximilian Niyazi, Chukwuka Eze, Minglun Li, Peter Bartenstein, Claus Belka, Ute Ganswindt
BACKGROUND: To determine the potential role of 68Ga-PSMA positron emission tomography/computed tomography (PET/CT) in radiotherapy (RT) planning for prostate cancer (PCa). METHODS: One hundred twenty-nine patients (pts) with 68Ga-PSMA PET/CT were retrospectively analysed. Potentially influencing factors (androgen deprivation therapy, amount of 68Ga-PSMA-HBED-CC, PSA doubling time ≤/> 10 months, PSA before PET/CT, T-/N-category and Gleason score) were evaluated by logistic regression analysis...
November 10, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29124039/surgical-management-of-stage-iiia-non-small-cell-lung-cancer
#13
REVIEW
Paul E Van Schil, Lawek Berzenji, Suresh K Yogeswaran, Jeroen M Hendriks, Patrick Lauwers
According to the eighth edition of the tumor-node-metastasis classification, stage III non-small cell lung cancer is subdivided into stages IIIA, IIIB, and IIIC. They represent a heterogeneous group of bronchogenic carcinomas with locoregional involvement by extension of the primary tumor and/or ipsilateral or contralateral lymph node involvement. Surgical indications have not been definitely established but, in general, long-term survival is only obtained in those patients in whom a complete resection is obtained...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29123013/68ga-psma-pet-ct-mapping-of-prostate-cancer-biochemical-recurrence-following-radical-prostatectomy-in-270-patients-with-psa-1-0ng-ml-impact-on-salvage-radiotherapy-planning
#14
Jérémie Calais, Johannes Czernin, Minsong Cao, Amar U Kishan, John V Hegde, Narek Shaverdian, Kiri A Sandler, Fang-I Chu, Chris R King, Michael L Steinberg, Isabel Rausher, Nina-Sophie Schmidt-Hegemann, Thorsten Poeppel, Philipp Hetkamp, Francesco Ceci, Ken Herrmann, Wolfgang P Fendler, Matthias Eiber, Nicholas G Nickols
Background: Target volume delineations for prostate cancer (PCa) salvage radiotherapy (SRT) after radical prostatectomy are usually drawn in the absence of visibly recurrent disease. Gallium-68 Prostate Specific Membrane Antigen Positron Emission Tomography/Computed Tomography (68Ga-PSMA-11 PET/CT) detects recurrent PCa with sensitivity superior to standard of care imaging at serum prostate specific antigen (PSA) values low enough to impact target volume delineations for routine SRT. OBJECTIVE: To i) map the recurrence pattern of PCa early biochemical recurrence (BCR) after radical prostatectomy with 68Ga-PSMA-11 PET/CT in patients with serum PSA levels <1 ng/ml, ii) determine how often consensus clinical target volumes (CTV) based on the Radiation Therapy Oncology Group (RTOG) guidelines cover 68Ga-PSMA-11 PET/CT-defined disease, and iii) assess the potential impact of 68Ga-PSMA-11 PET/CT on SRT...
November 9, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29112994/risk-of-recurrence-after-endoscopic-resection-of-early-colorectal-cancer-with-positive-margins
#15
Je-Wook Shin, Kyung Su Han, Jong Hee Hyun, Sang Jae Lee, Bun Kim, Chang Won Hong, Byung Chang Kim, Dae Kyung Sohn, Hee Jin Chang, Min Jung Kim, Sung Chan Park, Jae Hwan Oh
Background and study aim Additional surgery is recommended if an endoscopically resected T1 colorectal cancer (CRC) specimen shows a positive resection margin. We aimed to investigate the significance of a positive resection margin in endoscopically resected T1 CRC. Patients and methods We enrolled 265 patients with T1 CRC who underwent endoscopic resection between January 2001 and December 2016. The inclusion criteria were: 1) complete resection by endoscopy, and 2) pathology of a positive margin. Among the 265 patients, 213 underwent additional surgery and 52 did not...
November 7, 2017: Endoscopy
https://www.readbyqxmd.com/read/29064140/incidence-and-clinical-profile-of-tuberculosis-after-allogeneic-stem-cell-transplantation
#16
Narendra Agrawal, Mukul Aggarwal, Jyotsna Kapoor, Rayaz Ahmed, Anjan Shrestha, Meena Kaushik, Dinesh Bhurani
BACKGROUND: Patients post allogeneic stem cell transplantation (alloSCT) are expected to be at high risk of tuberculosis (TB) owing to underlying immunosuppression. We conducted a retrospective study in patients post alloSCT for clinical features and factors associated with TB. METHODS: Records of all patients transplanted from January 1, 2012 until December 31, 2015 were reviewed. Diagnosis of TB was considered if Mycobacterium tuberculosis was cultured from clinical samples or acid-fast bacilli (AFB) demonstrated on histopathology/smears...
October 24, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29029496/-177-lu-psma-617-radioligand-therapy-for-a-patient-with-lymph-node-metastatic-prostate-cancer
#17
Finn E von Eyben, Timo Kiljunen, Timo Joensuu, Kalevi Kairemo, Christian Uprimny, Irene Virgolini
Prostate specific membrane antigen (PSMA) is expressed in unfavorable prostate cancer. PSMA is basis for new diagnostics and theranostics. PET/CT using PSMA is more sensitive than choline PET/CT. (177)Lu-PSMA radioligand therapy is mainly used for patients with end-stage prostate cancer. This report describes a patient with a third recurrence in lymph nodes. The recurrence was treated with (177)Lu-PSMA radioligand therapy instead of chemotherapy with docetaxel. The effect was in part evaluated relative to that of two established salvage treatments...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29028767/prostate-specific-membrane-antigen-guided-salvage-lymph-node-dissection-in-recurrent-prostate-cancer-a-novel-technology-to-detect-lymph-node-metastases
#18
Tobias Maurer, Jürgen E Gschwend, Matthias Eiber
PURPOSE OF REVIEW: With Gallium (Ga)-prostate-specific membrane antigen (PSMA) PET/computed tomography (CT) as emerging imaging technique offering superior detection rates in biochemical recurrent prostate cancer, salvage lymph node dissection has gained increasing interest in localized oligometastatic prostate cancer. Currently, PSMA-targeting small molecules cannot only be linked to positron-emitting isotopes for imaging but also be labelled with γ-radiation emitting isotopes. These modified PSMA agents are evaluated for intraoperative guidance for resection of metastatic lymph nodes...
October 11, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28988428/risk-factors-for-salvage-surgery-failure-in-oral-cavity-squamous-cell-carcinoma
#19
Danielli Matsuura, Tiago Dias Valim, Marco Aurélio Vamondes Kulcsar, Fábio Roberto Pinto, Lenine Garcia Brandão, Claudio Roberto Cernea, Leandro Luongo Matos
OBJECTIVES/HYPOTHESIS: Locoregional recurrences of oral cavity squamous cell carcinoma (SCC) may be diagnosed during follow-up of surgically treated patients. Nevertheless, few studies have investigated factors that impact salvage surgery failure and the mortality rates of these patients. The objectives were to identify predictive factors of salvage surgery failure and mortality in patients who undergo surgical treatment for recurrent oral cavity SCC and to compare the overall survival rates of these patients with those of patients who undergo only one surgical treatment...
October 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28958827/re-robot-assisted-salvage-lymph-node-dissection-for-clinically-recurrent-prostate-cancer
#20
Vito Pansadoro, Aldo Brassetti
No abstract text is available yet for this article.
September 25, 2017: European Urology
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