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https://www.readbyqxmd.com/read/28634489/a-study-of-patients-with-primary-mediastinal-germ-cell-tumors-treated-using-multimodal-therapy
#1
Yutaro Tanaka, Takehiko Okamura, Takashi Nagai, Daichi Kobayashi, Takahiro Kobayashi, Hidetoshi Akita, Yoshinobu Moritoki, Takahiro Yasui
OBJECTIVES: Primary mediastinal germ cell tumors (PMGCTs) are rare, which often makes them difficult to treat. Herein, we examined patients with PMGCTs who underwent multimodal treatment. METHODS: We examined 6 patients (median age: 25 years, range: 19-27 years) with PMGCTs who underwent multimodal treatment between April 2001 and March 2015. Three patients had seminomas, 2 patients had yolk sac tumors, and 1 patient had choriocarcinoma. The median observation period was 32...
2017: Advances in Urology
https://www.readbyqxmd.com/read/28632694/multiorgan-involvement-of-chemotherapy-induced-sarcoidosis-mimicking-progression-of-lymphoma-on-fdg-pet-ct
#2
Prateek Sanan, Yang Lu
A 35-year-old woman with biopsy-proven recurrent Hodgkin lymphoma in the neck lymph nodes received salvage chemotherapy of brentuximab/insulin growth factor-methotrexate. Although the patient continued doing well clinically with no constitutional symptoms or significant laboratory abnormalities following the second recurrence, subsequent FDG PET CT examinations over the next 2 years revealed multiple new FDG-avid foci including lymph nodes above/below the diaphragm, liver, spleen, lungs, and bone. An alternate diagnosis of chemotherapy-induced sarcoidosis was suggested and confirmed on both bone marrow and right inguinal node biopsy...
June 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28631160/role-of-imaging-in-the-follow-up-of-t2-t3-glottic-cancer-treated-by-transoral-laser-microsurgery
#3
Filippo Marchi, Cesare Piazza, Marco Ravanelli, Giovanna Gaggero, Giampiero Parrinello, Alberto Paderno, Pietro Perotti, Marta Filauro, Roberto Maroldi, Giorgio Peretti
An unblinded retrospective analysis of prospectively collected data was carried out on 138 patients affected by glottic pT2 and selected pT3 squamous cell carcinomas (SCC) treated by transoral laser microsurgery (TLM). The entire cohort was divided into two groups: Group A included 78 "high-risk" patients (pT2 with impaired vocal cord mobility, pT3 for anterior paraglottic and/or pre-epiglottic space invasion, presence of angioembolization, perineural spread, and positive lymph nodes in the neck) who underwent postoperative surveillance by endoscopy and imaging (CT or MR), while Group B included 60 "low-risk" patients (pT2 with absence of the above-mentioned features) who underwent endoscopic follow-up alone...
June 19, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28587972/salvage-photodynamic-therapy-accompanied-by-extended-lymphadenectomy-for-advanced-esophageal-carcinoma-a-case-report
#4
Takahiro Nishida, Shinsuke Takeno, Koji Nakashima, Masato Kariya, Haruhiko Inatsu, Kazuo Kitamura, Atsushi Nanashima
INTRODUCTION: Salvage surgery for locoregional failures after definitive chemoradiotherapy (dCRT) for esophageal cancer is widely practiced, but treatment options complementing it are also needed due to the high morbidity and mortality and low rate of curative resection. PRESENTATION OF CASE: A 58-year-old man with a surgical history of right upper lobectomy for lung cancer was diagnosed as having esophageal squamous cell carcinoma. Computed tomography revealed swelling of the lesser curvature lymph node, and it had invaded the stomach, the body and tail of the pancreas and the left gastric artery, splenic artery and celiac artery...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28551815/the-efficacy-of-surgical-treatment-of-recurrent-or-persistent-cervical-cancer-that-develops-in-a-previously-irradiated-field-a-monoinstitutional-experience
#5
Seiji Mabuchi, Yuri Matsumoto, Naoko Komura, Masaaki Sawada, Mie Tanaka, Eriko Yokoi, Katsumi Kozasa, Akihiko Yoshimura, Hiromasa Kuroda, Tadashi Kimura
BACKGROUND: There are no guidelines about the selection of recurrent cervical cancer patients for salvage surgery. METHODS: Patients who developed recurrent or persistent cervical cancer in a previously irradiated field and were subsequently treated with salvage surgery (the surgery group) or palliative care alone (the palliative group) were identified. Patient characteristics, treatment-related complications, and survival were retrospectively compared between the two groups...
May 27, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28548372/initial-multicentre-experience-of-68-gallium-psma-pet-ct-guided-robot-assisted-salvage-lymphadenectomy-acceptable-safety-profile-but-oncological-benefit-appears-limited
#6
Amila Siriwardana, James Thompson, Pim J van Leeuwen, Shaela Doig, Anton Kalsbeek, Louise Emmett, Warick Delprado, David Wong, Hemamali Samaratunga, Anne-Maree Haynes, Geoff Coughlin, Phillip Stricker
OBJECTIVES: To evaluate the safety and short-term oncological outcomes for (68) Ga-PSMA PET/CT directed robot-assisted salvage node dissection (RASND) for prostate cancer oligometastatic nodal recurrence. MATERIALS AND METHODS: Between February 2014 and April 2016, 35 patients across two centres underwent RASND for (68) Ga-PSMA PET/CT detected oligometastatic nodal recurrence. RASND was performed by targeted pelvic dissection, unilateral extended pelvic template or bilateral extended pelvic template dissection, depending on previous pelvic treatment and extent/location of nodal disease...
May 26, 2017: BJU International
https://www.readbyqxmd.com/read/28547760/blinded-review-of-archival-radical-prostatectomy-specimens-supports-that-contemporary-gleason-score-6-prostate-cancer-lacks-metastatic-potential
#7
Luciano A Nunez Bragayrac, Christine Murekeyisoni, Michael J Vacchio, Kristopher Attwood, Diana C Mehedint, James L Mohler, Gissou Azabdaftari, Bo Xu, Eric C Kauffman
BACKGROUND: Retrospective identification of Gleason pattern 4 in metastatic Gleason score 3 + 3 = 6 (GS6) radical prostatectomy (RP) specimens has suggested true GS6 prostate cancer (CaP) lacks metastatic potential. However, pathologist awareness of study design and metastasis outcomes at the time of RP review might have introduced upgrading bias. We used pathologist-blinded methodology for unbiased characterization of metastasis rates for contemporarily defined pathologic GS6 (pGS6) CaP...
May 26, 2017: Prostate
https://www.readbyqxmd.com/read/28537697/image-guided-percutaneous-targeting-of-lymph-nodes-a-novel-approach-for-salvage-pelvic-lymphadenectomy-in-recurrent-prostate-cancer
#8
Gustavo Caserta Lemos, Arie Carneiro, Guilherme Cayres Mariotti, Jose Roberto Colombo, Marcelo Apezzato, Marcelo Livorsi da Cunha, Fernado Cotait Maluf, Rodrigo Gobbo Garcia
No abstract text is available yet for this article.
May 23, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28529650/diagnostic-accuracy-of-ga-68-hbed-cc-psma-ligand-pet-ct-before-salvage-lymph-node-dissection-for-recurrent-prostate-cancer
#9
Cordula A Jilg, Vanessa Drendel, H Christian Rischke, Teresa Beck, Werner Vach, Kathrin Schaal, Ulrich Wetterauer, Wolfgang Schultze-Seemann, Philipp T Meyer
Background: By targeting the prostate-specific membrane antigen (PSMA) on prostate cancer (PCa) cells PSMA-PET/CT shows great potential in locating the site of biochemical recurrence even at low PSA (Prostate-specific antigen)-levels. Accurate imaging of PCa recurrent lymph node metastases (LNM) is crucial for metastases directed therapies such as salvage-lymph node dissection (salvage-LND). Objective: To evaluate the diagnostic accuracy of PSMA-PET/CT for detection of affected lymph-node regions at salvage-LND for nodal recurrence of PCa...
2017: Theranostics
https://www.readbyqxmd.com/read/28522176/re-diagnostic-accuracy-of-ga-68-hbed-cc-psma-ligand-pet-ct-before-salvage-lymph-node-dissection-for-recurrent-prostate-cancer
#10
Boris Hadaschik, Ken Herrmann
No abstract text is available yet for this article.
May 15, 2017: European Urology
https://www.readbyqxmd.com/read/28514301/unusual-axillary-metastasis-of-recurrent-nasopharyngeal-cancer-a-case-report
#11
Deng-Yu Kuo, Min-Hsiang Chang, Shan-Ying Wang, Pei-Ying Hsieh, Pei-Wei Shueng
RATIONALE: Nasopharyngeal carcinoma (NPC) has a high propensity of metastasis. The most commonly described sites of distant metastasis are the bones, lungs, and liver, whereas axillary metastasis is seldom reported. PATIENT CONCERNS: We hereby present the case of a 66-year-old man with NPC, cT2N2M0, at diagnosis. He had completed chemoradiotherapy and been disease-free for 7 years. DIAGNOSES: After that period, late recurrence in the form of a solitary axillary lymph node metastasis was detected and confirmed by core-needle biopsy...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28511221/-psma-radioguided-surgery-for-salvage-lymphadenectomy-in-recurrent-prostate-cancer
#12
Isabel Rauscher, Matthias Eiber, Tobias Maurer
Recently, the use of (111)In-labeled PSMA-I&T-based radioguided surgery ((111)In-PSMA(-)RGS) for salvage surgery using intraoperative ex-vivo γ-probe measurements has been described by our group as a promising new and individual treatment concept in patients with localised recurrent prostate cancer (PC). (111)In-PSMA-RGS allowed for the intraoperative identification of metastatic lesions with a sensitivity, specificity and accuracy of 92.3, 93.5 and 93.1%, respectively, compared to histopathology. (111)In-PSMA-RGS was able to detect 5 additional lymph node metastases in 3 out of 31 patients compared to (68)Ga-HBED-CC-PSMA PET...
April 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28506050/-a-clinicopathologic-study-of-6-patients-with-histologically-pure-seminoma-but-elevated-serum-alpha-fetoprotein
#13
Shuya Kandori, Koji Kawai, Ken Tanaka, Takashi Kawahara, Atsushi Ikeda, Ryutaro Ishitsuka, Tomokazu Kimura, Takahiro Kojima, Akira Joraku, Jun Miyazaki, Hiroyuki Nishiyama
Histologically pure seminoma with elevated alpha-fetoprotein (AFP), so-called AFP-positive seminoma, is rare. It is recommended that patients with AFP-positive seminoma be managed as non-seminoma, but the clinical features and prognosis of this disease are not fully understood. In this study, we retrospectively analyzed 6 cases of metastatic AFP-positive seminoma at Tsukuba University Hospital (TUH). AFP was elevated before induction chemotherapy in 4 patients with an average of 1,372 ng/ml. In the remaining 2 patients, AFP became elevated during or after induction chemotherapy...
April 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28501419/brachytherapy-for-conservative-treatment-of-invasive-penile-carcinoma-prognostic-factors-and-long-term-analysis-of-outcome
#14
Alexandre Escande, Christine Haie-Meder, Renaud Mazeron, Pierre Maroun, Andrea Cavalcanti, Renaud de Crevoisier, Antoine Schernberg, Fanny Marsolat, Pierre Blanchard, Florent Martinetti, Alberto Bossi, Isabelle Dumas, Eric Deutsch, Cyrus Chargari
PURPOSE: To report the largest experience with brachytherapy as a conservative approach for the treatment of penile carcinoma. METHODS AND MATERIALS: We examined the outcomes of 201 patients treated at our institution over 45 years for invasive squamous cell carcinoma of the glans penis by brachytherapy. RESULTS: With a median follow-up of 10.7 years, local relapse as first failure was reported in 37 patients (18.9%), and 24 of 31 patients (77...
February 28, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28500118/isolated-prostate-cancer-soft-tissue-recurrence-10-years-after-radical-prostatectomy
#15
Munad Khan, Adee-Jonathan Davidson, Madeleine McKinley, Joseph Ischia
In advanced disease, prostate cancer is well known to invade locally as well as metastasise to distant locations. Metastases occur commonly in lymph nodes and bone but have also been known to involve certain visceral organs, particularly the lungs. Involvement of soft tissue by metastases is far less common, particularly in the context of cancer recurrence. We present the case of a male aged 68 years who presented with a rising prostate-specific antigen (PSA) 10 years after radical prostatectomy (RP). The PSA increased despite salvage radiotherapy and was ultimately found to be caused by a PSA secreting prostate cancer soft tissue mass in the suprapubic region...
May 12, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28496081/-salvage-surgery-following-chemoradiotherapy-for-thymic-basaloid-cell-carcinoma
#16
Takashi Inoue, Yoshiyuki Ito, Morimichi Nishihira, Osamu Araki, Yoko Karube, Sumiko Maeda, Satoru Kobayashi, Noriyuki Ikeda, Hiromichi Inoue, Motohiko Tamura, Yuji Matsumura, Masayuki Chida
We performed salvage surgery after chemoradiotherapy(CRT) in a patient with thymic basaloid cell carcinoma. A 46-year-old man with an abnormal chest shadow on X-ray findings was referred to our hospital. Computed tomography revealed a partially solid tumor along with a multilocular cyst in the anterior mediastinum with mediastinal lymph node swelling infiltrating to the superior vena cava(SVC). Positron emission tomography revealed FDG accumulation (SUVmax 7.94)in the tumor. Pathological findings of a tumor biopsy specimen obtained by thoracoscopy led to a diagnosis of thymic basaloid cell carcinoma...
May 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28462154/an-explanatory-case-on-the-limitations-of-lymph-node-staging-in-recurrent-prostate-cancer
#17
Marco Bandini, Giorgio Gandaglia, Nicola Fossati, Francesco Montorsi, Alberto Briganti
We describe the case of a 54-year-old man with nodal recurrence prostate cancer after radical prostatectomy, salvage external-beam radiotherapy and salvage lymph node dissection. The patient was evaluated with a lymphotropic ultrasmall superparamagnetic particles of iron oxide (USPIO)-MRI and a (68)Ga radiolabelled prostate specific membrane antigen (Ga68-PSMA) PET-CT scan which enhanced persistent localized nodal disease. The patient was then considered for a second robot-assisted extended S-LND. Differently from preoperative imaging, pathology report revealed a wide nodal involvement mirroring a metastatic disease...
May 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28453803/does-cervical-lymph-node-recurrence-after-oesophagectomy-or-definitive-chemoradiotherapy-for-thoracic-oesophageal-squamous-cell-carcinoma-benefit-from-salvage-treatment
#18
Xiaoli Yuan, Jiahua Lv, Hang Dong, Jiuhui Wang
A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was 'Does cervical lymph node recurrence after oesophagectomy or definitive chemoradiotherapy for thoracic oesophageal squamous cell carcinoma benefit from salvage treatment?' Altogether, 659 articles were found using the reported search, of which 8 represented the best evidence to answer the clinical question. The authors, journal, date, country of publication, patient group studied, study type, relevant outcomes and results of these articles were tabulated...
May 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28446984/salvage-surgery-after-high-dose-radiotherapy
#19
REVIEW
Annemie Van Breussegem, Jeroen M Hendriks, Patrick Lauwers, Paul E Van Schil
Salvage surgery is a relatively new entity in thoracic surgery and oncology. Salvage resection after radiotherapy refers to surgery as only remaining therapeutic option in patients who were treated with high-dose stereotactic radiotherapy (SRT) for early-stage lung cancer or full-dose chemoradiation for locally advanced lung cancer. Indications include locally progressive tumors, recurrent local or locoregional disease, or specific complications after radiotherapy such as lung abscesses or infected, necrotic cavities...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28444768/implantable-doppler-monitoring-of-buried-free-flaps-during-vascularized-lymph-node-transfer
#20
Chad M Teven, Adrian S H Ooi, Amir Inbal, David W Chang
BACKGROUND AND OBJECTIVES: Reliable flap monitoring is crucial to the success of free tissue transfer, including vascularized lymph node transfer (VLNT). However, no large-scale study has examined implantable Doppler monitoring in VLNT. We aimed to determine whether an implantable Doppler system can reliably monitor flap perfusion during VLNT and also to calculate the sensitivity and specificity of this system for detecting compromise in the monitored vessel. METHODS: An analysis of prospectively collected data of patients who underwent buried VLNT with implantable Doppler monitoring between 2014 and 2015 was performed...
April 25, 2017: Journal of Surgical Oncology
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