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https://www.readbyqxmd.com/read/28077625/radiotherapy-for-localized-gastric-mucosa-associated-lymphoid-tissue-lymphoma-long-term-outcomes-over-10-years
#1
Yu Ohkubo, Yoshihiro Saito, Hiroki Ushijima, Masahiro Onishi, Tomoko Kazumoto, Jun-Ichi Saitoh, Nobuko Kubota, Hirofumi Kobayashi, Nobuo Maseki, Yu Nishimura, Masafumi Kurosumi
This study aimed to assess the long-term outcomes of radiotherapy in patients with localized gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Twenty-seven patients with Stage I gastric MALT lymphoma were treated with radiotherapy from 1999 to 2010. The median age was 65 years (range: 31-84). Fifteen patients were Helicobacter pylori-negative. Thirteen patients were treated with definitive radiotherapy alone. The other 14 patients who had refractory or residual disease following a prior treatment received salvage radiotherapy...
January 10, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28043707/salvage-lymph-node-dissection-for-node-only-recurrence-of-prostate-cancer-ready-for-prime-time
#2
EDITORIAL
Nazareno Suardi, Alberto Briganti, Giorgio Gandaglia, Nicola Fossati, Francesco Montorsi
Several studies show that salvage lymph-node dissection for node-only recurrence of prostate cancer after radical treatment might represent a viable treatment modality for node-only recurrent PCa. However, as long as high quality data is not available, this approach should still be considered experimental.
December 30, 2016: European Urology
https://www.readbyqxmd.com/read/28018903/impact-of-lymph-node-burden-on-survival-of-high-risk-prostate-cancer-patients-following-radical-prostatectomy-and-pelvic-lymph-node-dissection
#3
Lisa Moris, Thomas Van den Broeck, Lorenzo Tosco, Anthony Van Baelen, Paolo Gontero, Robert Jeffrey Karnes, Wouter Everaerts, Maarten Albersen, Patrick J Bastian, Piotr Chlosta, Frank Claessens, Felix K Chun, Markus Graefen, Christian Gratzke, Burkhard Kneitz, Giansilvio Marchioro, Rafael Sanchez Salas, Bertrand Tombal, Henk Van Der Poel, Jochen Christoph Walz, Gert De Meerleer, Alberto Bossi, Karin Haustermans, Francesco Montorsi, Hendrik Van Poppel, Martin Spahn, Alberto Briganti, Steven Joniau
AIM: To determine the impact of the extent of lymph node invasion (LNI) on long-term oncological outcomes after radical prostatectomy (RP). MATERIAL AND METHODS: In this retrospective study, we examined the data of 1,249 high-risk, non-metastatic PCa patients treated with RP and pelvic lymph node dissection (PLND) between 1989 and 2011 at eight different tertiary institutions. We fitted univariate and multivariate Cox models to assess independent predictors of cancer-specific survival (CSS) and overall survival (OS)...
2016: Frontiers in Surgery
https://www.readbyqxmd.com/read/28003586/current-status-and-future-prospects-for-esophageal-cancer-treatment
#4
Makoto Sohda, Hiroyuki Kuwano
The local control effect of esophagectomy with three-field lymph node dissection (3FLD) is reaching its limit pending technical advancement. Minimally invasive esophagectomy (MIE) by thoracotomy is slowly gaining acceptance due to advantages in short-term outcomes. Although the evidence is slowly increasing, MIE is still controversial. Also, the results of treatment by surgery alone are limiting, and multimodality therapy, which includes surgical and non-surgical treatment options including chemotherapy, radiotherapy, and endoscopic treatment, has become the mainstream therapy...
December 21, 2016: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27981731/robotic-salvage-retroperitoneal-and-pelvic-lymph-node-dissection-for-node-only-recurrent-prostate-cancer-technique-and-initial-series
#5
Andre Luis de Castro Abreu, Carlos E S Fay, Daniel Park, David Quinn, Tanya Dorff, John Carpten, Peter Kuhn, Parkash Gill, Fabio Almeida, Inderbir S Gill
OBJECTIVES: To describe the technique of robotic high-extended salvage retroperitoneal and pelvic lymphadenectomy (sRPLND+PLND) for 'node-only' recurrent prostate cancer. MATERIALS AND METHODS: Ten patients underwent robotic sRPLND+PLND (09/2015-03/2016) for 'node-only' recurrent prostate cancer, as identified by carbon-11 acetate PET/CT imaging. Our anatomic template extends from bilateral renal artery/vein cranially up to Cloquet's node caudally, completely excising lymphatic-fatty tissue from aorto-caval and iliac vascular trees; RPLND precedes PLND...
December 15, 2016: BJU International
https://www.readbyqxmd.com/read/27964921/esophagectomy-outcomes-in-the-endoscopic-mucosal-resection-era
#6
Karen J Dickinson, Kenneth Wang, Lizhi Zhang, Mark S Allen, Stephen D Cassivi, Francis C Nichols, Robert Shen, Dennis A Wigle, Shanda H Blackmon
BACKGROUND: Endoscopic mucosal resection (EMR) and esophagectomy are treatment options for cT1 esophageal adenocarcinoma. Our aim was to study outcomes for patients undergoing EMR then esophagectomy. METHODS: We identified patients undergoing EMR and esophagectomy for cT1 esophageal adenocarcinoma over 10 years. EMR histology was used to predict nodal involvement with a risk-scoring tool. Patient demographics, surgical techniques, pathology, postoperative outcomes, and survival were recorded...
December 10, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27927229/evaluation-of-tumor-recurrences-after-radical-prostatectomy-using-18f-choline-pet-ct-and-3t-multiparametric-mri-without-endorectal-coil-a-single-center-experience
#7
Felipe Couñago, Manuel Recio, Antonio Maldonado, Elia Del Cerro, Ana Aurora Díaz-Gavela, Israel J Thuissard, David Sanz-Rosa, Francisco José Marcos, Karmele Olaciregui, María Mateo, Laura Cerezo
BACKGROUND: To evaluate and compare the utility of 18F-fluorocholine (18F-CH) PET/CT versus 3-Tesla multiparametric MRI (mpMRI) without endorectal coil to detect tumor recurrences in patients with biochemical relapse following radical prostatectomy (RP). Secondarily, to identify possible prognostic variables associated with mpMRI and 18F-CH PET/CT findings. METHODS: Retrospective study of 38 patients who developed biochemical recurrence after RP between the years 2011 and 2015 at our institution...
December 7, 2016: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/27909618/clinico-pathological-outcomes-of-post-primary-and-salvage-chemotherapy-retroperitoneal-lymph-node-dissection-for-mixed-germ-cell-tumors-king-hussein-cancer-center-experience
#8
Kholoud Alqasem, Ibrahim Abukhiran, Judy Jasser, Tamer Bisharat, Riyad T Ellati, Jakub Khzouz, Ibrahim Al-Saidi, Ali Al-Daghamin
OBJECTIVE: We sought to characterize clinical and pathologic outcomes of advanced mixed germ cell tumors after retroperitoneal lymph node dissection for post-chemotherapy residual masses. MATERIAL AND METHODS: Between January 2006 and November 2015, 56 patients underwent retroperitoneal lymph node dissection (RPLND) for residual masses of greater than 1 cm after receiving either primary chemotherapy or salvage chemotherapy. Retrospective review of the patients' characteristics, clinical, pathological, and treatment outcomes were performed after institutional review board (IRB) and ethics committee approval...
December 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27843030/adjuvant-radiation-therapy-for-margin-positive-vulvar-squamous-cell-carcinoma-defining-the-ideal-dose-response-using-the-national-cancer-data-base
#9
Bhavana V Chapman, Beant S Gill, Akila N Viswanathan, Goundappa K Balasubramani, Paniti Sukumvanich, Sushil Beriwal
PURPOSE: Positive surgical margins after radical vulvectomy for vulvar cancer portend a high risk for local relapse, which may be challenging to salvage. We assessed the impact of adjuvant radiation therapy (aRT) on overall survival (OS) and the dose-response relationship using the National Cancer Data Base. METHODS AND MATERIALS: Patients with vulvar squamous cell carcinoma who underwent initial extirpative surgery with positive margins from 1998 to 2012 were included...
January 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27826686/resin-based-yttrium-90-microspheres-for-unresectable-and-failed-first-line-chemotherapy-intrahepatic-cholangiocarcinoma-preliminary-results
#10
Zhongzhi Jia, Ricardo Paz-Fumagalli, Gregory Frey, David M Sella, J Mark McKinney, Weiping Wang
PURPOSE: To evaluate the value of resin-based yttrium-90 ((90)Y) radioembolization for unresectable and failed first-line chemotherapy (cisplatin plus gemcitabine) intrahepatic cholangiocarcinoma (ICC). METHODS: From February 2006 to September 2015, a retrospective study was conducted of all patients who underwent resin-based (90)Y therapy for unresectable and failed first-line chemotherapy ICC. Tumor response was assessed using modified RECIST criteria; side effects were assessed using Common Terminology Criteria for Adverse Events version 4...
November 8, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27824042/the-role-of-salvage-extended-lymph-node-dissection-in-patients-with-rising-psa-and-pet-ct-scan-detected-nodal-recurrence-of-prostate-cancer
#11
D Porres, D Pfister, A Thissen, T H Kuru, V Zugor, R Buettner, R Knuechel, F A Verburg, A Heidenreich
BACKGROUND: Non-prostatic bed recurrence of prostate cancer (PCa) is usually treated with androgen deprivation therapy (ADT). We analyzed the impact of salvage extended lymph node dissection (sLND) on cancer control in patients with rising PSA and lymph node (LN) metastases. METHODS: Between 2009 and 2016 we performed sLND in 87 patients with biochemical recurrence (BCR) and positive LNs on (18)FEC and (68)Ga-PSMA positron emission tomography/X-ray computer tomography (PET/CT) after primary treatment (PT) of PCa...
November 8, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27822478/comparison-and-prognostic-analysis-of-adjuvant-radiotherapy-versus-salvage-radiotherapy-for-treatment-of-radically-resected-locally-advanced-esophageal-squamous-cell-carcinoma
#12
Xin Xu, Hua-Ying Xie, Di Zhou, Ren-Hua Huang, Yong-Rui Bai, Jun Yuan, Ming Ye
Objective. To compare adjuvant radiotherapy and salvage radiotherapy after radical resection for treatment of esophageal squamous cell carcinoma (ESCC). Methods. Data from 155 patients with locally advanced ESCC who underwent radical resection and received postoperative radiotherapy from 2005 to 2011 were reviewed. Seventy-nine patients received adjuvant radiotherapy and 76 received salvage radiotherapy after locoregional recurrence. Results. The median disease-free survival (DFS) and overall survival (OS) were significantly higher in the adjuvant radiotherapy group than the salvage radiotherapy group (DFS 25...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27800245/chemotherapy-in-retinoblastoma-current-approaches
#13
REVIEW
Özge Yanık, Kaan Gündüz, Kıvılcım Yavuz, Nurdan Taçyıldız, Emel Ünal
Retinoblastoma (RB) is the most common childhood malignant intraocular tumor. Although enucleation and external beam radiotherapy have been historically used, today the most commonly used eye-sparing approach is chemotherapy. Chemotherapy can be used in both intraocular and extraocular RB cases. Chemotherapeutic agents may be applied in different ways, including systemic, subconjunctival, intra-arterial and intravitreal routes. The main purposes of application of systemic therapy are to reduce the tumor size for local treatment (chemoreduction), or to reduce the risk of metastasis after enucleation surgery (adjuvant therapy)...
December 2015: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27766725/definitive-chemoradiation-for-locoregional-recurrences-of-esophageal-cancer-after-primary-curative-treatment
#14
P M Jeene, E Versteijne, M I van Berge Henegouwen, J J G H M Bergmann, E D Geijsen, K Muller, H W M van Laarhoven, M C C M Hulshof
The aim of this study was to determine the outcome of salvage definitive chemoradiation (dCRT) for a locoregional recurrence after any prior curative treatment outside previously irradiated areas. Thirty-nine patients treated between January 2005 and December 2014 were reviewed for locoregional recurrent esophageal cancer outside previously irradiated areas. All patients received salvage treatment with external beam radiotherapy (50.4 Gy in 28 fractions) combined with weekly concurrent paclitaxel and carboplatin...
October 21, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27765102/-gastric-pull-up-reconstruction-after-pharyngoesphagectomy-for-advanced-hypopharyngeal-or-cervical-esophageal-squamous-cell-carcinoma
#15
C M An, S X Wang, F Lyu, S Y Liu, Z G Xu, P Z Tang, S G Gao, J L Yi, Z J Li
Objective: To analyze the clinical results of gastric pull-up reconstruction following total pharyngoesophagectomy. Methods: A total of 90 patients with hypopharyngeal or cervical esophageal cancinoma who underwent gatric pull-up reconstruction after pharyngoesophagectomy between June 2006 and June 2015 were reviewed retrospectively. Clinical data were analyzed. Rates of survival, recurrence and complicates were calculated with SPSS software. Results: Of 90 patients, 8 patients had hypopharyngeal cancinoma invading cervical esophagus, 51 patients had cervical esophageal carcinoma, and 31 patients had hypophageal and esophageal multiple parimary carcinomas...
October 7, 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/27753187/factors-associated-with-regional-recurrence-following-lymphadenectomy-for-penile-squamous-cell-carcinoma
#16
Jay P Reddy, Curtis A Pettaway, Lawrence B Levy, Lance C Pagliaro, Pheroze Tamboli, Priya Rao, Isuru Jayaratna, Karen E Hoffman
OBJECTIVE: To identify factors associated with regional recurrence (RR) following lymphadenectomy for penile cancer in order to determine which patients might benefit from adjuvant therapy. MATERIALS/METHODS: Men who underwent lymphadenectomy for penile squamous cell carcinoma from 1977-2014 were identified from an institutional database. Kaplan-Meier curves estimated recurrence-free survival (RFS) calculated from the date of lymphadenectomy. Cox regression models evaluated the association between RFS and patient and tumor characteristics...
October 18, 2016: BJU International
https://www.readbyqxmd.com/read/27752756/pet-imaging-for-lymph-node-dissection-in-prostate-cancer
#17
Elena Incerti, Paola Mapelli, Luigi Gianolli, Maria Picchio
The detection of neoplastic lymph nodal involvement in prostate cancer (PCa) patients has relevant therapeutic and prognostic significance, both in the clinical settings of primary staging and restaging. Lymph nodal dissection (LND) currently represents the gold standard for evaluating the presence of lymph nodal involvement. However, this procedure is invasive, associated with morbidity, and may fail in detecting all potential lymph nodal metastatic regions. Currently the criteria for lymph nodal detection using conventional imaging techniques mainly rely on morphological assessment with unsatisfactory diagnostic accuracy...
October 17, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27716240/salvage-surgery-for-local-failures-after-stereotactic-ablative-radiotherapy-for-early-stage-non-small-cell-lung-cancer
#18
Naomi E Verstegen, Alexander P W M Maat, Frank J Lagerwaard, Marinus A Paul, Michel I Versteegh, Joris J Joosten, Willem Lastdrager, Egbert F Smit, Ben J Slotman, Joost J M E Nuyttens, Suresh Senan
INTRODUCTION: The literature on surgical salvage, i.e. lung resections in patients who develop a local recurrence following stereotactic ablative radiotherapy (SABR), is limited. We describe our experience with salvage surgery in nine patients who developed a local recurrence following SABR for early stage non-small cell lung cancer (NSCLC). METHODS: Patients who underwent surgical salvage for a local recurrence following SABR for NSCLC were identified from two Dutch institutional databases...
October 3, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27704661/isolated-local-recurrence-or-solitary-solid-organ-metastasis-after-esophagectomy-for-cancer-is-not-the-end-of-the-road
#19
L Depypere, T Lerut, J Moons, W Coosemans, G Decker, H Van Veer, P De Leyn, P Nafteux
Recurrent disease after esophagectomy bears an infaust prognosis, especially when multiple recurrences are present. But little is known about survival in patients with limited recurrence (solitary locoregional recurrence or solid organ metastasis). Herein, we report our experience with these subgroups. We analyzed 1754 consecutive patients surgically treated with curative resection for esophageal cancer and cancer of the gastroesophageal junction between 1990 and 2012. Seven subgroups were defined according to the recurrence type (locoregional vs...
October 5, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27692833/risk-of-lymph-node-metastases-in-pathological-gleason-score%C3%A2-6-prostate-adenocarcinoma-analysis-of-institutional-and-population-based-databases
#20
Hannah Wenger, Adam B Weiner, Aria Razmaria, Gladell P Paner, Scott E Eggener
INTRODUCTION: Several institutional studies have suggested that pathological Gleason score≤6 prostate cancer has little or no capacity for metastasis. MATERIALS AND METHODS: Using the Surveillance, Epidemiology, and End Results database (SEER, 2004-2011, n = 19,594) and the National Cancer Database (NCDB, 2004-2013, n = 57,540), we identified patients with pathological Gleason score≤6 prostate cancer following radical prostatectomy and lymph node dissection...
January 2017: Urologic Oncology
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