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intra-ocular lens

Dulcia W N Tan, Soo Ghim Lim, Tina T Wong, Subbu S Venkatraman
Currently, infections following cataract surgery are not as effectively managed with antibiotic eye drops, which suffer from poor bioavailability of drug and low patient compliance. The ideal solution, which can help to overcome the issue of drug wastage and poor bioavailabilty, as well as the need for frequent applications (patient inconvenience), is a drug-eluting intraocular lens (IOL). We describe a novel approach to such a drug-eluting lens by using a peripheral IOL attachment as a drug depot to deliver antibiotics, Levofloxacin (LFX) or Moxifloxacin (MFX)...
2016: PloS One
Tabassum A Kennedy, Nathan Connell, Timothy Szczykutowicz, Sebastian Schafer, Kevin Royalty, Sara Nace, Brian Gartrell, Samuel Gubbels
HYPOTHESIS: Flat-panel computed tomography (FPCT) will allow more accurate localization of cochlear implants with decreased metallic artifact and decreased radiation dose when compared with multi-detector CT (MDCT). BACKGROUND: The measurement of scalar location and intra-scalar position of cochlear implantation (CI) electrodes using computed tomography (CT) is complicated by metallic image artifact and insufficient scalar resolution. FPCT has been shown to improve upon the resolution of MDCT while reducing artifact...
September 23, 2016: Otology & Neurotology
Ashley A Weaver, Sarah M Stitzel, Joel D Stitzel
A predictive Lagrangian-Eulerian finite element eye model was used to analyze 2.27 and 0.45 kg trinitrotoluene equivalent blasts detonated from 24 different locations. Free air and ground level blasts were simulated directly in front of the eye and at lateral offset locations with box, average, less protective, and more protective orbital anthropometries, resulting in 96 simulations. Injury risk curves were developed for hyphema, lens dislocation, retinal damage, and globe rupture from experimental and computational data to compute risk from corneoscleral stress and intra-ocular pressure computational outputs...
September 19, 2016: Biomechanics and Modeling in Mechanobiology
Prabu Baskaran, Seema Ramakrishnan, Pankaja Dhoble, Joseph Gubert
PURPOSE: To report a case of beta-hemolytic streptococcal endophthalmitis following crane-pecking injury. CASE REPORT: A twelve-year-old boy was brought to us by his father with history of crane beak injury in his right eye. On examination, his vision was 6/24 Snellen's acuity. Anterior segment examination showed a full thickness two mm corneo-limbal tear at 1 o'clock with iris prolapse. Pupil showed peaking through the wound with a clear crystalline lens. There was no evidence of hypopyon in the anterior chamber and B-scan ultrasonography showed acoustically clear vitreous with an attached retina...
2016: GMS Ophthalmol Cases
Charlotte Barbé, Nathaniel Harran, Frédéric Goulle
PURPOSE: To determine intra- and interobserver reliability of lens equatorial length measurement using 35-MHz ultrasound biomicroscopy in dogs with cataract. METHODS: Ocular ultrasonography was performed on 28 dogs (50 eyes) before phacoemulsification. Lens equatorial length was measured on still images obtained at 35 MHz in all dogs. Each observer (A and B) obtained the measurements independently. Coefficients of variation (CVs) were used to assess intraobserver repeatability and interobserver reproducibility...
August 13, 2016: Veterinary Ophthalmology
Eddie Wadbro, Per Hallberg, Staffan Schedin
Based on numerical 3D ray tracing, we propose a new procedure to optimize personalized intra-ocular lenses (IOLs). The 3D ray tracing was based on measured corneal elevation data from patients who suffered from advanced keratoconus. A mathematical shape description of the posterior IOL surface, by means of a tensor product cubic Hermite spline, was implemented. The optimized lenses provide significantly reduced aberrations. Our results include a trade-off study that suggests that it is possible to considerably reduce the aberrations with only minor perturbations of an ideal spherical lens...
June 1, 2016: Applied Optics
R Barbara, S R Rufai, N Tan, J E Self
Refractive correction of aphakia in childhood can be a complex management issue following lensectomy for congenital cataract or ectopia lentis. Some children have inadequate capsular support to allow an 'in the bag' or sulcus fixated intra-ocular lens (IOL). In such cases, options for refractive correction include spectacles, contact lenses, or surgically fixed IOLs. Many methods of IOL fixation have been described, but none are widely adopted in children. In recent years, the iris-fixated Artisan Aphakic IOL has gained popularity, but there is still significant concern about the rate of corneal endothelial cell loss and IOL de-enclavation...
September 2016: Eye
Ali Tayyab, Amena Masrur, Farooq Afzal, Fyza Iqbal, Kamran Naseem
OBJECTIVE: To measure central corneal thickness in Pakistani population and determine its relationship to intra-ocular pressure, age, gender and ethnicity. STUDY DESIGN: Cross-sectional observation study. PLACE AND DURATION OF STUDY: Pakistan Institute of Medical Sciences, Islamabad, Pakistan, between December 2013 and February 2015. METHODOLOGY: The right eyes of 1000 cases (496 males and 504 females) were recruited for this study...
June 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Esben Nielsen, Anders Ivarsen, Simon Kristensen, Jesper Hjortdal
PURPOSE: To investigate the determining factors of vision and subjective outcome after Descemet's stripping automated endothelial keratoplasty (DSAEK) for Fuchs' endothelial dystrophy (FECD). METHODS: In a prospective study, 41 FECD patients who received DSAEK were compared to 40 cataract patients with normal corneas who received cataract surgery (control group). Subjects were recruited between March 2013 and July 2014. Observational procedures included the following: best-corrected visual acuity (BCVA), contrast sensitivity (CS), Catquest-9SF questionnaire, Scheimpflug tomography and anterior OCT...
June 7, 2016: Acta Ophthalmologica
Renaud Laballe, Jonathan Vigne, Eric Denion, Florian Lemaitre, Didier Goux, Pierre-Jean Pisella
PURPOSE: Bacterial keratitis is a sight threatening infection of the cornea which remains one of the most important potential complications of contact lens use. If the corneal ulcer is small, peripheral with no impending perforation present, intensive monotherapy with fluoroquinolones could be used. Therefore, a study was conducted with the objective to provide pharmacological data of the intra-ocular diffusion after administration of Ofloxacin using a scleral lens reservoir, as well as an evaluation of surface tolerability in rabbits...
October 2016: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
Ahmed Sivardeen, Deborah Laughton, James S Wolffsohn
PURPOSE: To determine the utility of a range of clinical and non-clinical indicators to aid the initial selection of the optimum presbyopic contact lens. In addition, to assess whether lens preference was influenced by the visual performance compared to the other designs trialled (intra-subject) or compared to participants who preferred other designs (inter-subject). METHODS: A double-masked randomised crossover trial of Air Optix Aqua multifocal, PureVision 2 for Presbyopia, Acuvue OASYS for Presbyopia, Biofinity multifocal and monovision was conducted on 35 presbyopes (54...
October 2016: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
Mohit Parekh, Alessandro Ruzza, Stefano Ferrari, Massimo Busin, Diego Ponzin
INTRODUCTION: To determine the feasibility of preloading endothelial tissues for Descemet membrane endothelial keratoplasty (DMEK). DESIGN: Laboratory investigation. METHODS: setting: Institutional. PARTICIPANTS: Twenty human donor corneas unsuitable for transplantation with endothelial cell density in a range of 1600-2700 cells/mm(2). INTERVENTION: The endothelium was punched, stripped (8.5 mm diameter) and manually tri-folded with the endothelial side inward...
June 2016: American Journal of Ophthalmology
Ghasem Fakhraie, Zahra Mohajernezhad-Fard, Sasan Moghimi, Zakieh Vahedian, Yadollah Eslami, Reza Zarei
PURPOSE: To evaluate the safety and efficacy of phacoemulsification for management of post-filtering ocular hypotony. METHODS: This prospective interventional case series study recruited 21 consecutive patients with an established diagnosis of ocular hypotony with or without maculopathy. Clear corneal incision phacoemulsification was done for all patients. Nineteen cases that completed a follow-up of at least 6 months were considered for final analysis. RESULTS: Mean baseline intraocular pressure (IOP) was 2...
October 2015: Journal of Ophthalmic & Vision Research
Thevi Thanigasalam, Sagili Chandrashekara Reddy, Rafdzah Ahmad Zaki
PURPOSE: Cataract surgery is the most common intraocular surgery performed all over the world and has advanced technically in recent years. As in all surgeries, complications are unavoidable. Herein we report factors associated with complications and visual outcomes of cataract surgery. METHODS: This retrospective cohort study included data of 1,632 cataract surgeries performed from 2007 to 2010 which was obtained from the cataract registry of the Malaysian National Eye Database...
October 2015: Journal of Ophthalmic & Vision Research
S Yu Anisimova, S I Anisimov, I V Novak, K M Avsineeva, L L Arutyunyan, M A Al'daravish
AIM: to perform comparative evaluation of intra- and postoperative clinical RESULTS in patients with complicated cataracts (grade I-II lens subluxation, pseudoexfoliation syndrome, or surgically treated glaucoma) undergoing either standard or femtosecond laser-assisted phacoemulsification. MATERIAL AND METHODS: A total of 197 patients (245 eyes) aged 32-85 years (58.5 years on average) with complicated cataracts were divided into two groups by the technique used for phacoemulsification...
January 2016: Vestnik Oftalmologii
Atsushi Kawahara, Tsugiaki Utsunomiya, Yuji Kato, Yoshinori Takayanagi
BACKGROUND: The aim of this study was to compare the effects of nepafenac ophthalmic suspension 0.1% (Nevanac) and diclofenac sodium ophthalmic solution 0.1% (Diclod) on the cornea, tear film, and ocular surface after cataract surgery. METHODS: A total of 60 eyes (60 patients) were selected for this study, with no ocular diseases other than cataract (scheduled for cataract surgery by one surgeon). Patients were randomly enrolled to receive nepafenac or diclofenac in the perioperative period, and cataract surgery was performed using torsional microcoaxial phacoemulsification and aspiration with intraocular lens implantation via a transconjunctival single-plane sclerocorneal incision at the 12 o'clock position...
2016: Clinical Ophthalmology
Furqan A Maulvi, Dhara H Lakdawala, Anjum A Shaikh, Ankita R Desai, Harsh H Choksi, Rutvi J Vaidya, Ketan M Ranch, Akshay R Koli, Bhavin A Vyas, Dinesh O Shah
Glaucoma is commonly treated using eye drops, which is highly inefficient due to rapid clearance (low residence time) from ocular surface. Contact lenses are ideally suited for controlled drug delivery to cornea, but incorporation of any drug loaded particulate system (formulation) affect the optical and physical property of contact lenses. The objective of the present work was to implant timolol maleate (TM) loaded ethyl cellulose nanoparticle-laden ring in hydrogel contact lenses that could provide controlled drug delivery at therapeutic rates without compromising critical lens properties...
March 28, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
Mary S A Attia, Gerd U Auffarth, Ramin Khoramnia, Katharina Linz, Florian T A Kretz
PURPOSE: To evaluate reading performance of a trifocal intra-ocular lens (IOL) at near and intermediate distances using the Salzburg Reading Desk. SETTING: International Vision Correction Research Centre and David J. Apple Laboratory, University Eye Clinic, Heidelberg, Germany. DESIGN: Prospective, nonrandomized clinical study. METHODS: Follow-up examinations at a minimum of 3 months postoperatively included uncorrected (UDVA) and corrected (CDVA) distance visual acuity, uncorrected (UIVA) and distance-corrected (DCIVA)) intermediate as well as uncorrected (UNVA) and distance-corrected (DCNVA) near visual acuity...
December 2015: Journal of Cataract and Refractive Surgery
Li Wang, Omar Shoukfeh, Douglas D Koch
PURPOSE: To determine the optimum amount of spherical aberration in intra-ocular lenses (IOLs) to maximize optical quality in eyes with previous hyperopic corneal surgery. SETTING: Cullen Eye Institute, Baylor College of Medicine, Houston, Texas. DESIGN: Theoretical simulation study. METHODS: The amount of spherical aberration in the IOL was varied to produce residual ocular spherical aberration ranging from -0.50 to +0...
December 2015: Journal of Cataract and Refractive Surgery
Xiaodi Qiu, Yinghong Ji, Tianyu Zheng, Yi Lu
PURPOSE: To evaluate the efficacy and complications of black diaphragm intra-ocular (BDI) lens implantation in patients with congenital aniridia. METHODS: Twenty patients underwent BDI lens implantation for the treatment of congenital aniridia from January 1999 to December 2012. Fifteen patients (23 eyes) were enrolled in our study, and the mean follow-up period was 26 months. Patient demographics, clinical evaluations [visual acuity (VA), best-corrected visual acuity (BCVA), intra-ocular pressure measurement (IOP), corneal endothelial cell density (ECD) and ultrasound biomicroscopy (UBM)], complications and treatments were analysed for each patient...
August 2016: Acta Ophthalmologica
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