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Cancer Childhood

Jikui Guan, Susanne Fransson, Joachim Tetteh T Siaw, Diana Treis, Jimmy Van den Eynden, Damini Chand, Ganesh Umapathy, Petter Svenberg, Kristina Ruuth, Sandra Wessman, Alia Shamikh, Hans Jacobsson, Lena Gordon, Jakob Stenman, Erik Larsson, Par-Johan Svensson, Magnus Hansson, Tommy Martinsson, Per Kogner, Ruth H Palmer, Bengt Hallberg
Tumors with Anaplastic Lymphoma Kinase (ALK) fusion rearrangements, including non-small cell lung cancer and anaplastic large cell lymphoma, are highly sensitive to ALK tyrosine kinase inhibitors (TKIs), underscoring the notion that such cancers are addicted to ALK activity. While mutations in ALK are heavily implicated in childhood neuroblastoma, response to the ALK TKI crizotinib has been disappointing. Embryonal tumors in patients with DNA repair defects such as Fanconi anemia (FA) often have a poor prognosis, due to lack of therapeutic options...
June 15, 2018: Cold Spring Harbor Molecular Case Studies
Laure Brigitte Kouitcheu Mabeku, Michelle Larissa Noundjeu Ngamga, Hubert Leundji
BACKGROUND: Helicobacter pylori is a Gram negative bacterium that colonizes the stomach of approximately two-thirds of the human population and it is involved in the pathogenesis of gastroduodenal diseases. This study sought to determine potential risk factors associated with seroprevalence of H. pylori among dyspepsia patients in Cameroon for a better management of the disease. METHODS: The study was carried out from August to December 2014 at Laquintinie Hospital and District Hospital of Bonassama in Douala metropolis...
June 15, 2018: BMC Infectious Diseases
Kristina Thorsteinsson, Merete Storgaard, Terese L Katzenstein, Steen Ladelund, Frederikke F Rönsholt, Isik Somuncu Johansen, Gitte Pedersen, Anne Gaardsting, Lars Nørregård Nielsen, Jesper Bonde, Anne-Mette Lebech
BACKGROUND: Women living with HIV (WLWH) have elevated risk of human papillomavirus (HPV) related cancers. OBJECTIVES: To assess prevalence, distribution and concordance of cervical, oral, and anal HPV infection, and predictors of oral and anal HPV in WLWH in Denmark. STUDY DESIGN: WLWH followed in the Study on HIV, cervical Abnormalities and infections in women in Denmark (SHADE) were enrolled and examined for cervical, oral, and anal HPV infection...
May 25, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Rahel Kasteler, Linda M H Kam, Annette Weiss, Nicolas Waespe, Grit Sommer, Florian Singer, Nicolas X von der Weid, Marc Ansari, Claudia E Kuehni
BACKGROUND: Childhood cancer survivors are at increased risk for pulmonary morbidity and mortality. International guidelines recommend pulmonary function tests (PFT) during follow-up care. This nationwide study assessed how many children received PFT within 5 years after pulmotoxic treatment in Switzerland, types of tests, and predictors for testing. METHODS: We included all children from the Swiss Childhood Cancer Registry who were diagnosed with cancer from 1990 to 2013 at age 0-16 years, survived for ≥2 years from diagnosis, and had pulmotoxic chemotherapy with bleomycin, busulfan, nitrosoureas, and/or chest radiotherapy...
June 15, 2018: Pediatric Blood & Cancer
Amélie Poidvin, Jean-Claude Carel, Emmanuel Ecosse, Dominique Levy, Jean Michon, Joël Coste
The association between growth hormone (GH) treatment and cancer risk has not been thoroughly evaluated and there are questions about any increased risk of bone tumors. We examined cancer risk and especially bone tumor risk in a population-based cohort study of 6874 patients treated with recombinant GH in France for isolated GH deficiency, short stature associated with low birth weight or length or idiopathic short stature. Adult mortality and morbidity data obtained from national databases and from questionnaires...
June 14, 2018: Cancer Medicine
Mary Eapen
No abstract text is available yet for this article.
June 14, 2018: Blood
Joanne Woodford, Anna Wikman, Martin Cernvall, Gustaf Ljungman, Amanda Romppala, Helena Grönqvist, Louise von Essen
INTRODUCTION: A subgroup of parents of children previously treated for cancer report long-term psychological distress after end of treatment. However, needs for psychological support are commonly unmet and there is a lack of evidence-based treatments tailored to the specific needs of this population. An internet-administered, guided, cognitive-behavioural therapy-based, self-help intervention (ENGAGE) for parents of children previously treated for cancer may provide a solution. The aim is to examine the feasibility and acceptability of the intervention ENGAGE and the study procedures for a future controlled trial...
June 14, 2018: BMJ Open
Judith Gebauer, Sarah Rieken, Sonja Schuster, Birgit Hahn, Niklas Gebauer, Norbert Meidenbauer, Georg Brabant, Markus Metzler, Thorsten Langer
No abstract text is available yet for this article.
June 15, 2018: Oncology Research and Treatment
Kirsten R Ballantine, Susan Hanna, Scott Macfarlane, Peter Bradbeer, Lochie Teague, Sarah Hunter, Siobhan Cross, Jane Skeen
AIM: To evaluate the completeness and accuracy of child cancer registration in New Zealand. METHODS: Registrations for children aged 0-14 diagnosed between 1/1/2010 and 31/12/2014 were obtained from the New Zealand Cancer Registry (NZCR) and the New Zealand Children's Cancer Registry (NZCCR). Six key data fields were matched using National Health Index numbers in order to identify and resolve registration discrepancies. Capture-recapture methods were used to assess the completeness of cancer registration...
June 11, 2018: Cancer Epidemiology
Laura Kann, Tim McManus, William A Harris, Shari L Shanklin, Katherine H Flint, Barbara Queen, Richard Lowry, David Chyen, Lisa Whittle, Jemekia Thornton, Connie Lim, Denise Bradford, Yoshimi Yamakawa, Michelle Leon, Nancy Brener, Kathleen A Ethier
PROBLEM: Health-risk behaviors contribute to the leading causes of morbidity and mortality among youth and adults in the United States. In addition, significant health disparities exist among demographic subgroups of youth defined by sex, race/ethnicity, and grade in school and between sexual minority and nonsexual minority youth. Population-based data on the most important health-related behaviors at the national, state, and local levels can be used to help monitor the effectiveness of public health interventions designed to protect and promote the health of youth at the national, state, and local levels...
June 15, 2018: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
Irene Tadeo, Esther Gamero-Sandemetrio, Ana P Berbegall, Marta Gironella, Félix Ritort, Adela Cañete, Gloria Bueno, Samuel Navarro, Rosa Noguera
Neuroblastoma is the most common extra-cranial solid pediatric cancer and causes approximately 15% of all childhood deaths from cancer. Although lymphatic vasculature is a prerequisite for the maintenance of tissue fluid balance and immunity in the body, little is known about the relationship between lymphatic vascularization and prognosis in neuroblastoma. We used our previously-published custom-designed tool to close open-outline vessels and measure the density, size and shape of all lymphatic vessels and microvascular segments in 332 primary neuroblastoma contained in tissue microarrays...
May 25, 2018: Oncotarget
Marzia Ognibene, Gabriella Pagnan, Danilo Marimpietri, Davide Cangelosi, Michele Cilli, Maria Chiara Benedetti, Renata Boldrini, Alberto Garaventa, Francesco Frassoni, Alessandra Eva, Luigi Varesio, Vito Pistoia, Annalisa Pezzolo
Neuroblastoma is an aggressive, relapse-prone childhood tumor of the sympathetic nervous system that accounts for 15% of pediatric cancer deaths. A distal portion of human chromosome 3p is often deleted in neuroblastoma, this region may contain one or more putative tumor suppressor genes. A 2.54 Mb region at 3p26.3 encompassing the smallest region of deletion pinpointed CHL1 gene, the locus for neuronal cell adhesion molecule close homolog of L1. We found that low CHL1 expression predicted poor outcome in neuroblastoma patients...
May 25, 2018: Oncotarget
Mark P Little, Zaria Tatalovich, Martha S Linet, Michelle Fang, Gerald M Kendall, Michael G Kimlin
Solar ultraviolet radiation is the primary risk factor for skin cancers and sun-related eye disorders. Estimates of individual ambient ultraviolet irradiance derived from ground-based solar measurements and from satellite measurements have rarely been compared. Using self-reported residential history from 67,189 persons in a nationwide occupational US radiologic technologists cohort, we estimated ambient solar irradiance using data from ground-based meters and noontime satellite measurements. The mean distance-moved from city of longest residence in childhood increased from 137...
June 13, 2018: Photochemistry and Photobiology
Christina Wei, Elizabeth Crowne
Endocrine abnormalities are common among childhood cancer survivors. Abnormalities of the hypothalamic-pituitary-adrenal axis (HPAA) are the least common, but the consequences are severe if missed. Patients with tumours located and /or had surgery performed near the hypothalamic-pituitary region and those treated with an accumulative cranial radiotherapy dose of over 30 Gy are most at risk of adrenocorticotrophic hormone (ACTH) deficiency. Primary adrenal insufficiency may occur in patients with tumours located in or involving one or both adrenals...
June 12, 2018: Endocrine-related Cancer
Daniel J Zheng, Kevin R Krull, Yan Chen, Lisa Diller, Yutaka Yasui, Wendy Leisenring, Pim Brouwers, Rebecca Howell, Jin-Shei Lai, Lyn Balsamo, Kevin C Oeffinger, Leslie L Robison, Gregory T Armstrong, Nina S Kadan-Lottick
BACKGROUND: Neuroblastoma survivors may be at elevated risk for psychological impairments because of their young age at diagnosis and neurotoxic treatment, but this is not well described. METHODS: A total of 859 ≥5-year survivors of neuroblastoma younger than 18 years (diagnosed in 1970-1999), who had a median age at diagnosis of 0.8 years (range: 0.0-7.3 years) and a median follow-up of 13.3 years (range: 8.0-17.9 years), were compared with 872 siblings of childhood cancer survivors who were younger than 18 years with the parent-reported Behavior Problem Index (BPI) for psychological functioning...
June 11, 2018: Cancer
(no author information available yet)
On June 5, President Donald Trump signed the Childhood Cancer Survivorship, Treatment, Access and Research Act, which aims to support pediatric cancer research by expanding the collection of patient biospecimens and records, improving surveillance, and investigating pediatric survivorship.
June 7, 2018: Cancer Discovery
Susanne N Gröbner, Barbara C Worst, Joachim Weischenfeldt, Ivo Buchhalter, Kortine Kleinheinz, Vasilisa A Rudneva, Pascal D Johann, Gnana Prakash Balasubramanian, Maia Segura-Wang, Sebastian Brabetz, Sebastian Bender, Barbara Hutter, Dominik Sturm, Elke Pfaff, Daniel Hübschmann, Gideon Zipprich, Michael Heinold, Jürgen Eils, Christian Lawerenz, Serap Erkek, Sander Lambo, Sebastian Waszak, Claudia Blattmann, Arndt Borkhardt, Michaela Kuhlen, Angelika Eggert, Simone Fulda, Manfred Gessler, Jenny Wegert, Roland Kappler, Daniel Baumhoer, Stefan Burdach, Renate Kirschner-Schwabe, Udo Kontny, Andreas E Kulozik, Dietmar Lohmann, Simone Hettmer, Cornelia Eckert, Stefan Bielack, Michaela Nathrath, Charlotte Niemeyer, Günther H Richter, Johannes Schulte, Reiner Siebert, Frank Westermann, Jan J Molenaar, Gilles Vassal, Hendrik Witt, Birgit Burkhardt, Christian P Kratz, Olaf Witt, Cornelis M van Tilburg, Christof M Kramm, Gudrun Fleischhack, Uta Dirksen, Stefan Rutkowski, Michael Frühwald, Katja von Hoff, Stephan Wolf, Thomas Klingebiel, Ewa Koscielniak, Pablo Landgraf, Jan Koster, Adam C Resnick, Jinghui Zhang, Yanling Liu, Xin Zhou, Angela J Waanders, Danny A Zwijnenburg, Pichai Raman, Benedikt Brors, Ursula D Weber, Paul A Northcott, Kristian W Pajtler, Marcel Kool, Rosario M Piro, Jan O Korbel, Matthias Schlesner, Roland Eils, David T W Jones, Peter Lichter, Lukas Chavez, Marc Zapatka, Stefan M Pfister, Peter Lichter, Ursula Weber, Roland Eils, Andrey Korshunov, Olaf Witt, Stefan Pfister, Guido Reifenberger, Jörg Felsberg, Christof von Kalle, Manfred Schmidt, Cynthia Bartholomä, Michael Taylor, Stefan Pfister, David Jones, Peter Lichter, Natalie Jäger, Ivo Buchhalter, Jan Korbel, Adrian Stütz, Tobias Rausch, Bernhard Radlwimmer, Marie-Laure Yaspo, Hans Lehrach, Hans-Jörg Warnatz, Pablo Landgraf, Arndt Borkhardt, Benedikt Brors, Marc Zapatka, Roland Eils, Roland Eils, Jürgen Eils, Christian Lawerenz, Reiner Siebert, Susanne Wagner, Andrea Haake, Julia Richter, Gesine Richter, Roland Eils, Chris Lawerenz, Jürgen Eils, Jules Kerssemakers, Christina Jaeger-Schmidt, Ingrid Scholz, Anke K Bergmann, Christoph Borst, Birgit Burkhardt, Alexander Claviez, Martin Dreyling, Sonja Eberth, Hermann Einsele, Norbert Frickhofen, Siegfried Haas, Martin-Leo Hansmann, Dennis Karsch, Michael Kneba, Jasmin Lisfeld, Luisa Mantovani-Löffler, Marius Rohde, German Ott, Christina Stadler, Peter Staib, Stephan Stilgenbauer, Lorenz Trümper, Thorsten Zenz, Martin-Leo Hansmann, Dieter Kube, Ralf Küppers, Marc Weniger, Michael Hummel, Wolfram Klapper, Ulrike Kostezka, Dido Lenze, Peter Möller, Andreas Rosenwald, German Ott, Monika Szczepanowski, Ole Ammerpohl, Sietse M Aukema, Vera Binder, Arndt Borkhardt, Andrea Haake, Jessica I Hoell, Ellen Leich, Peter Lichter, Cristina López, Inga Nagel, Jordan Pischimariov, Bernhard Radlwimmer, Julia Richter, Philip Rosenstiel, Andreas Rosenwald, Markus Schilhabel, Stefan Schreiber, Inga Vater, Rabea Wagener, Reiner Siebert, Stephan H Bernhart, Hans Binder, Benedikt Brors, Gero Doose, Roland Eils, Steve Hoffmann, Lydia Hopp, Daniel Hübschmann, Kortine Kleinheinz, Helene Kretzmer, Markus Kreuz, Jan Korbel, David Langenberger, Markus Loeffler, Maciej Rosolowski, Matthias Schlesner, Peter F Stadler, Stephanie Sungalee
In this Article, author Benedikt Brors was erroneously associated with affiliation number '8' (Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, Tennessee, USA); the author's two other affiliations (affiliations '3' and '7', both at the German Cancer Research Center (DKFZ)) were correct. This has been corrected online.
June 6, 2018: Nature
Adel A Hagag, Ibrahim M Badraia, Mohamed M Abdelmageed, Nahed M Hablas, Sahar Me Hazzaa, Nahla A Nosair
BACKGROUND: Acute lymphoblastic leukemia (ALL) is the commonest childhood cancer. Transferrin receptor 1 (CD71) is a trans-membrane glycoprotein which has important role in iron homeostasis by acting as a gatekeeper regulating iron uptake from transferrin and is an attractive target for anti-cancer agents, particularly those that aim to induce lethal iron deprivation in malignant hematopoietic cells. AIM OF THE WORK: To assess the prognostic value of Transferrin receptor -1 (CD71) in children with newly diagnosed ALL...
June 4, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Saro H Armenian, Gregory T Armstrong, Gregory Aune, Eric J Chow, Matthew J Ehrhardt, Bonnie Ky, Javid Moslehi, Daniel A Mulrooney, Paul C Nathan, Thomas D Ryan, Helena J van der Pal, Elvira C van Dalen, Leontien C M Kremer
Cardiovascular disease (CVD), which includes cardiomyopathy/heart failure, coronary artery disease, stroke, pericardial disease, arrhythmias, and valvular and vascular dysfunction, is a major concern for long-term survivors of childhood cancer. There is clear evidence of increased risk of CVD largely attributable to treatment exposures at a young age, most notably anthracycline chemotherapy and chest-directed radiation therapy, and compounded by traditional cardiovascular risk factors accrued during decades after treatment exposure...
June 6, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Lisa B Kenney, Zoltan Antal, Jill P Ginsberg, Bradford S Hoppe, Sharon L Bober, Richard N Yu, Louis S Constine, Hanneke M van Santen, Roderick Skinner, Daniel M Green
Reproductive health is a common concern and often a source of distress for male childhood, adolescent, and young adult cancer survivors. Clinical and epidemiologic research in survivor populations has identified alkylating agent chemotherapy, testicular radiation, and surgery or radiation to the genitourinary organs, lower spine, or the hypothalamic-pituitary region as risk factors for adverse reproductive outcomes, including impaired spermatogenesis, testosterone insufficiency, and sexual dysfunction. Much of the research on male survivors has focused on the outcome of fertility, using spermatogenesis, serum gonadotropins, and paternity as the measures...
June 6, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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