keyword
MENU ▼
Read by QxMD icon Read
search

Becker

keyword
https://www.readbyqxmd.com/read/28634143/pcr-based-verification-of-positive-rapid-diagnostic-tests-for-intestinal-protozoa-infections-with-variable-test-band-intensity
#1
Sören L Becker, Ivan Müller, Pascal Mertens, Mathias Herrmann, Leyli Zondie, Lindsey Beyleveld, Markus Gerber, Rosa du Randt, Uwe Pühse, Cheryl Walter, Jürg Utzinger
Stool-based rapid diagnostic tests (RDTs) for pathogenic intestinal protozoa (e.g. Cryptosporidium spp. and Giardia intestinalis) allow for prompt diagnosis and treatment in resource-constrained settings. Such RDTs can improve individual patient management and facilitate population-based screening programmes in areas without microbiological laboratories for confirmatory testing. However, RDTs are difficult to interpret in case of 'trace' results with faint test band intensities and little is known about whether such ambiguous results might indicate 'true' infections...
June 17, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28634011/immunomodulatory-properties-of-concholepas-concholepas-hemocyanin-against-francisellosis-in-a-zebrafish-model
#2
Leidy Lagos, Julia I Tandberg, María Inés Becker, Hanne C Winther-Larsen
The development of vaccines for aquaculture has been an important milestone in providing a continuous and sustainable production. Most of the vaccines currently on the market for aquaculture include oil as adjuvant. Nevertheless, several studies reported an occurrence of side effects after their use in farmed fish. As a result, there is a need for new and improved adjuvants that can stimulate the immune system while causing as few side-effects as possible. Hemocyanins are versatile macromolecules with strong immunogenic and immunomodulatory properties...
June 17, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28633619/the-affect-misattribution-procedure
#3
Sarah Teige-Mocigemba, Manuel Becker, Jeffrey W Sherman, Regina Reichardt, Karl Christoph Klauer
The Affect Misattribution Procedure (AMP) has been forwarded as one of the most promising alternatives to the Implicit Association Test and the evaluative-priming task for measuring attitudes such as prejudice indirectly. We investigated whether the AMP is indeed able to detect an evaluative out-group bias. In contrast to recent conclusions about the robustness of AMP effects, six out of seven pilot studies indicated that participants did not show any prejudice effects in the AMP. Yet, these pilot studies were not fully conclusive with regard to our research question because they investigated different domains of prejudice, used small sample sizes, and employed a modified AMP version...
May 2017: Experimental Psychology
https://www.readbyqxmd.com/read/28630351/evolutionary-radiation-of-lanthipeptides-in-marine-cyanobacteria
#4
Andres Cubillos-Ruiz, Jessie W Berta-Thompson, Jamie W Becker, Wilfred A van der Donk, Sallie W Chisholm
Lanthipeptides are ribosomally derived peptide secondary metabolites that undergo extensive posttranslational modification. Prochlorosins are a group of lanthipeptides produced by certain strains of the ubiquitous marine picocyanobacteria Prochlorococcus and Synechococcus Unlike other lanthipeptide-producing bacteria, picocyanobacteria use an unprecedented mechanism of substrate promiscuity for the production of numerous and diverse lanthipeptides using a single lanthionine synthetase. Through a cross-scale analysis of prochlorosin biosynthesis genes-from genomes to oceanic populations-we show that marine picocyanobacteria have the collective capacity to encode thousands of different cyclic peptides, few of which would display similar ring topologies...
June 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28629744/mannose-receptor-modulates-macrophage-polarization-and-allergic-inflammation-through-mir-511-3p
#5
Yufeng Zhou, Danh C Do, Faoud T Ishmael, Mario Leonardo Squadrito, Ho Man Tang, Ho Lam Tang, Man-Hsun Hsu, Lipeng Qiu, Changjun Li, Yongqing Zhang, Kevin G Becker, Mei Wan, Shau-Ku Huang, Peisong Gao
BACKGROUND: Mannose receptor (MRC1/CD206) has been suggested to mediate allergic sensitization and asthma to multiple glyco-allergens, including cockroach allergens. OBJECTIVE: Determine the existence of a protective mechanism through which MRC1 limits allergic inflammation through its intronic miR-511-3p. METHODS: We examined the MRC1-mediated cockroach allergen uptake by lung macrophages and lung inflammation using C57BL/6 wild-type (WT) and Mrc1(-/-) mice...
June 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28629631/probenecid-treatment-reduces-demyelination-induced-by-cuprizone-feeding
#6
Nadine Hainz, Philipp Becker, Daniel Rapp, Stefan Wagenpfeil, Bodo Wonnenberg, Christoph Beisswenger, Thomas Tschernig, Carola Meier
Recent experiments showed that a pannexin-1 inhibitor, probenecid, reduced clinical symptoms in the murine experimental autoimmune encephalomyelitis when applied during the initial phase of neuronal inflammation. An inflammatory component is also present in a toxically induced inflammation and demyelination using cuprizone diet. Probenecid is a pannexin-1 antagonist and a probenecid therapy was investigated. Mice were fed for 10days with a cuprizone diet. In the following, the diet was continued but combined with a daily injection of a low dose of probenecid or solvent for 10days...
June 16, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/28629569/in-depth-analysis-of-interreader-agreement-and-accuracy-in-categorical-assessment-of-brown-adipose-tissue-in-18-fdg-pet-ct
#7
Anton S Becker, Caroline Zellweger, Khoschy Schawkat, Sanja Bogdanovic, Valerie Doan Phi van, Hannes W Nagel, Christian Wolfrum, Irene A Burger
PURPOSE: To evaluate the interreader agreement of a three-tier craniocaudal grading system for brown fat activation and investigate the accuracy of the distinction between the three grades. MATERIALS AND METHODS: After IRB approval, 340 cases were retrospectively selected from patients undergoing (18)FDG-PET/CT between 2007 and 2015 at our institution, with 85 cases in each grade and 85 controls with no active brown fat. Three readers evaluated all cases independently...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28629321/the-biocontrol-agent-pseudomonas-chlororaphis-pa23-primes-brassica-napus-defenses-through-distinct-gene-networks
#8
Kelly A Duke, Michael G Becker, Ian J Girard, Jenna L Millar, W G Dilantha Fernando, Mark F Belmonte, Teresa R de Kievit
BACKGROUND: The biological control agent Pseudomonas chlororaphis PA23 is capable of protecting Brassica napus (canola) from the necrotrophic fungus Sclerotinia sclerotiorum via direct antagonism. While we have elucidated bacterial genes and gene products responsible biocontrol, little is known about how the host plant responds to bacterial priming on the leaf surface, including global changes in gene activity in the presence and absence of S. sclerotiorum. RESULTS: Application of PA23 to the aerial surfaces of canola plants reduced the number of S...
June 19, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28628488/falls-and-physical-activity-in-persons-with-mild-to-moderate-dementia-participating-in-an-intensive-motor-training-randomized-controlled-trial
#9
Tania Zieschang, Michael Schwenk, Clemens Becker, Lorenz Uhlmann, Peter Oster, Klaus Hauer
BACKGROUND: Physical activity is beneficial in people with dementia. As physical activity increases risk exposure for falls, safety concerns arise. Prior exercise trials in people with dementia have not measured physical activity. Falls in relation to exposure time rather than person-years as outcome measure has been promoted but not investigated in people with dementia. METHODS: Patients with mild to moderate dementia (n=110) were randomized to an intensive, progressive strength and functional training intervention or to a low-intensity group training for 12 weeks each...
June 16, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28628216/a-fast-easy-and-customizable-eight-color-flow-cytometric-method-for-analysis-of-the-cellular-content-of-bronchoalveolar-lavage-fluid-in-the-mouse
#10
François Daubeuf, Julien Becker, Juan Antonio Aguilar-Pimentel, Claudine Ebel, Martin Hrabě de Angelis, Yann Hérault, Nelly Frossard
The cell composition of bronchoalveolar lavage fluid (BAL) is an important indicator of airway inflammation. It is commonly determined by cytocentrifuging leukocytes on slides, then staining, identifying, and counting them as eosinophils, neutrophils, macrophages, or lymphocytes according to morphological criteria under light microscopy, where it is not always easy to distinguish macrophages from lymphocytes. We describe here a one-step, easy-to-use, and easy-to-customize 8-color flow cytometric method for performing differential cell count and comparing it to morphological counts on stained cytospins...
June 19, 2017: Current Protocols in Mouse Biology
https://www.readbyqxmd.com/read/28627017/functional-expression-of-calcium-permeable-canonical-transient-receptor-potential-4-containing-channels-promotes-migration-of-medulloblastoma-cells
#11
Wei-Chun Wei, Wan-Chen Huang, Yu-Ping Lin, Esther B E Becker, Olaf Ansorge, Veit Flockerzi, Daniele Conti, Giovanna Cenacchi, Maike D Glitsch
Aberrant intracellular Ca(2+) signalling contributes to the formation and progression of a range of distinct pathologies including cancers. Rises in intracellular Ca(2+) concentration occur in response to Ca(2+) influx through plasma membrane channels and Ca(2+) release from intracellular Ca(2+) stores, which can be mobilised in response to activation of cell surface receptors. OGR1 (Ovarian cancer G protein coupled Receptor 1, aka GPR68) is a proton-sensing Gq -coupled receptor that is most highly expressed in cerebellum...
June 19, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28626944/food-insecurity-and-eating-disorder-pathology
#12
Carolyn Black Becker, Keesha Middlemass, Brigitte Taylor, Clara Johnson, Francesca Gomez
OBJECTIVE: The primary aim of this study was to investigate eating disorder (ED) pathology in those living with food insecurity. A secondary aim was to investigate whether any-reason dietary restraint, weight self-stigma, and worry increased as level of food insecurity increased. METHOD: Participants (N = 503) seeking food from food pantries completed questionnaires assessing level of food insecurity, demographics, ED pathology, dietary restraint, weight self-stigma, and worry...
June 18, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28626858/antibiotics-for-acute-bronchitis
#13
REVIEW
Susan M Smith, Tom Fahey, John Smucny, Lorne A Becker
BACKGROUND: The benefits and risks of antibiotics for acute bronchitis remain unclear despite it being one of the most common illnesses seen in primary care. OBJECTIVES: To assess the effects of antibiotics in improving outcomes and to assess adverse effects of antibiotic therapy for people with a clinical diagnosis of acute bronchitis. SEARCH METHODS: We searched CENTRAL 2016, Issue 11 (accessed 13 January 2017), MEDLINE (1966 to January week 1, 2017), Embase (1974 to 13 January 2017), and LILACS (1982 to 13 January 2017)...
June 19, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28626023/microarray-analysis-of-aging-associated-immune-system-alterations-in-the-rostral-ventrolateral-medulla-of-f344-rats
#14
Sivasai Balivada, Chanran K Ganta, Yongqing Zhang, Hitesh N Pawar, Richard J Ortiz, Kevin G Becker, Arshad M Khan, Michael J Kenney
The rostral ventrolateral medulla (RVLM) is an area of the brainstem that contains diverse neural substrates that are involved in systems critical for physiological function. There is evidence that aging affects some neural substrates within the RVLM, although age-related changes in RVLM molecular mechanisms are not well established. The goal of the present study was to characterize the transcriptomic profile of the aging RVLM and to test the hypothesis that aging is associated with altered gene expression in the RVLM, with an emphasis on immune system associated gene transcripts...
June 16, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/28625464/becker-s-nevus-and-lethal-beta-actin-mutations
#15
Rudolf Happle
The etiology of Becker's nevus and Becker's nevus syndrome has been until now unknown. Cai et al. provide evidence that these disorders are caused by lethal mutations in ACTB, a gene coding for beta-actin. They hypothesize that these mutations may interfere with Hedgehog pathway signaling. Their findings have important implications for clinical genetics, and they open new aspects in hair research.
June 16, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28624463/insights-from-genotype-phenotype-correlations-by-novel-speg-mutations-causing-centronuclear-myopathy
#16
Haicui Wang, Claudia Castiglioni, Ayşe Kaçar Bayram, Fabiana Fattori, Serdar Pekuz, Diego Araneda, Hüseyin Per, Ricardo Erazo, Hakan Gümüş, Suzan Zorludemir, Kerstin Becker, Ximena Ortega, Jorge Alfredo Bevilacqua, Enrico Bertini, Sebahattin Cirak
Centronuclear myopathies (CNM) are a clinically and genetically heterogeneous group of congenital myopathies, defined histologically by increased number of fibres with centrally located nuclei, and type I fibre predominance in muscle biopsy. Myotubular myopathy, the X-linked form of CNM caused by mutations in the phosphoinositide phosphatase MTM1, is histologically characteristic since muscle fibres resemble myotubes. Here we present two unrelated patients with CNM and typical myotubular fibres in the muscle biopsy caused by mutations in striated muscle preferentially expressed protein kinase (SPEG)...
May 24, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28624290/feasibility-of-reducing-differences-in-estimated-doses-in-nuclear-medicine-between-a-patient-specific-and-a-reference-phantom
#17
Alexandra Zvereva, Helmut Schlattl, Maria Zankl, Janine Becker, Nina Petoussi-Henss, Yeon Soo Yeom, Chan Hyeong Kim, Christoph Hoeschen, Katia Parodi
The feasibility of reducing the differences between patient-specific internal doses and doses estimated using reference phantoms was evaluated. Relatively simple adjustments to a polygon-surface ICRP adult male reference phantom were applied to fit selected individual dimensions using the software Rhinoceros®4.0. We tested this approach on two patient-specific phantoms: the biggest and the smallest phantoms from the Helmholtz Zentrum München library. These phantoms have unrelated anatomy and large differences in body-mass-index...
June 14, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28624022/whole-liver-ct-texture-analysis-to-predict-the-development-of-colorectal-liver-metastases-a-multicentre-study
#18
Rianne C J Beckers, Doenja M J Lambregts, Roald S Schnerr, Monique Maas, Sheng-Xiang Rao, Alfons G H Kessels, Thomas Thywissen, Geerard L Beets, Stefano Trebeschi, Janneke B Houwers, Cornelis H Dejong, Cornelis Verhoef, Regina G H Beets-Tan
OBJECTIVES: CT texture analysis has shown promise to differentiate colorectal cancer patients with/without hepatic metastases. AIM: To investigate whether whole-liver CT texture analysis can also predict the development of colorectal liver metastases. MATERIAL AND METHODS: Retrospective multicentre study (n=165). Three subgroups were assessed: patients [A] without metastases (n=57), [B] with synchronous metastases (n=54) and [C] who developed metastases within ≤24 months (n=54)...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28622813/evaluation-of-drug-use-and-medication-compliance-in-adolescents-admitted-to-a-psychiatric-facility-from-the-pediatric-emergency-department
#19
George Sam Wang, Genie Roosevelt, Amy Becker, Lina Brou, Jeffrey L Galinkin
OBJECTIVES: Knowledge of drug use and medication compliance during mental health evaluation can help guide evaluation and treatment. The objective was to evaluate drug use and medication compliance in a pediatric emergency department (PED) psychiatric population by comparing medical history, standard urine drug screen (EIA), and expanded urine drug screen (HPLC-MS/MS). METHODS: A prospective cohort study of admitted psychiatric patients ≥13years and ≤18years in a tertiary-care children's hospital psychiatric ED from January 31, 2013 through April 16, 2014...
May 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28622685/increased-pdgfr-beta-and-vegfr-2-protein-levels-are-associated-with-resistance-to-platinum-based-chemotherapy-and-adverse-outcome-of-ovarian-cancer-patients
#20
Stefanie Avril, Yasemin Dincer, Katharina Malinowsky, Claudia Wolff, Sibylle Gündisch, Alexander Hapfelmeier, Melanie Boxberg, Holger Bronger, Karl-Friedrich Becker, Barbara Schmalfeldt
Despite frequent initial response rates of epithelial ovarian cancer to platinum-based chemotherapy the majority of patients develop drug resistance. Our aim was to evaluate differential expression of signaling-pathway proteins in platinum-sensitive versus platinum-resistant primary epithelial ovarian cancer specimens to identify predictive biomarkers for treatment response.192 patients were studied comprising of independent training (n = 89) and validation (n = 103) cohorts. Full-length proteins were extracted from paraffin-embedded samples including multiple regions per tumor to account for intratumoral heterogeneity...
June 8, 2017: Oncotarget
keyword
keyword
59797
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"