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https://www.readbyqxmd.com/read/29784839/clonal-spread-in-candida-glabrata-bloodstream-isolates-and-fluconazole-resistance-affected-by-prolonged-exposure-a-12-year-single-center-study-in-belgium
#1
Berdieke Goemaere, Katrien Lagrou, Isabel Spriet, Marijke Hendrickx, Pierre Becker
Candida glabrata is a major cause of candidemia in immunocompromised patients and is characterized by a high-level of fluconazole resistance. In the present study, acquisition of antifungal resistance and potential clonal spread of C. glabrata were explored at a single center over a 12-year period by analyzing 187 independent clinical C. glabrata bloodstream isolates. One strain was found to be micafungin resistant due to a mutation in the FKS2 gene. Fluconazole resistance remained stable throughout the period and was observed in 20 (10...
May 21, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29784475/post-fabrication-qac-functionalized-thermoplastic-polyurethane-for-contact-killing-catheter-applications
#2
Zachary K Zander, Peiru Chen, Yen-Hao Hsu, Nathan Z Dreger, Laura Savariau, Willie C McRoy, Alec E Cerchiari, Sean D Chambers, Hazel A Barton, Matthew L Becker
The use of catheters is ubiquitous in medicine and the incidence of infection remains unacceptably high despite numerous advances in functional surfaces and drug elution. Herein we report the use of a thermoplastic polyurethane containing an allyl ether side-chain functionality (allyl-TPU) that allows for rapid and convenient surface modification with antimicrobial reagents, post-processing. This post-processing functionalization affords the ability to target appropriate TPU properties and maintain the functional groups on the surface of the device where they do not affect bulk properties...
May 11, 2018: Biomaterials
https://www.readbyqxmd.com/read/29783951/the-transcriptomic-and-proteomic-responses-of-daphnia-pulex-to-changes-in-temperature-and-food-supply-comprise-environment-specific-and-clone-specific-elements
#3
Dörthe Becker, Yann Reydelet, Jacqueline A Lopez, Craig Jackson, John K Colbourne, Susan Hawat, Michael Hippler, Bettina Zeis, Rüdiger J Paul
BACKGROUND: Regulatory adjustments to acute and chronic temperature changes are highly important for aquatic ectotherms because temperature affects their metabolic rate as well as the already low oxygen concentration in water, which can upset their energy balance. This also applies to severe changes in food supply. Thus, we studied on a molecular level (transcriptomics and/or proteomics) the immediate responses to heat stress and starvation and the acclimation to different temperatures in two clonal isolates of the model microcrustacean Daphnia pulex from more or less stressful environments, which showed a higher (clone M) or lower (clone G) tolerance to heat and starvation...
May 21, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29783160/children-s-sleep-problems-are-associated-with-poorer-student-teacher-relationship-quality
#4
Alex S Holdaway, Stephen P Becker
OBJECTIVE: Children's sleep problems are associated with poorer student functioning in the school environment, including impairment in peer relationships; yet, no studies have examined sleep functioning in relation to the student-teacher relationship. The objective of this study was to examine whether child-rated total sleep problems or specific sleep problem domains (bedtime problems, nighttime problems, or daytime sleepiness) were associated with teacher-rated student-teacher closeness and conflict after controlling for student mental health symptoms known to be associated with both greater sleep problems and poorer student-teacher relationship quality...
December 20, 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29783157/vaccines-and-the-association-with-relapses-in-patients-with-neuromyelitis-optica-spectrum-disorder
#5
Maureen A Mealy, Lawrence J Cook, Florence Pache, Diego L Velez, Nadja Borisow, Daniel Becker, Jorge A Jimenez Arango, Friedemann Paul, Michael Levy
BACKGROUND: It is unknown if vaccines cause non-specific immune activation in patients with neuromyelitis optica spectrum disorder and no consensus on the use of vaccines exists for this population. We investigated the temporal association of vaccinations with relapses in patients with neuromyelitis optica spectrum disorder. METHODS: This is a multi-center retrospective analysis of patients with neuromyelitis optica spectrum disorder for whom immunization history and clinical records from disease onset were available...
May 7, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29782514/quantifying-lion-panthera-leo-demographic-response-following-a-three-year-moratorium-on-trophy-hunting
#6
Thandiwe Mweetwa, David Christianson, Matt Becker, Scott Creel, Elias Rosenblatt, Johnathan Merkle, Egil Dröge, Henry Mwape, Jones Masonde, Twakundine Simpamba
Factors that limit African lion populations are manifold and well-recognized, but their relative demographic effects remain poorly understood, particularly trophy hunting near protected areas. We identified and monitored 386 individual lions within and around South Luangwa National Park, Zambia, for five years (2008-2012) with trophy hunting and for three additional years (2013-2015) during a hunting moratorium. We used these data with mark-resight models to estimate the effects of hunting on lion survival, recruitment, and abundance...
2018: PloS One
https://www.readbyqxmd.com/read/29782365/utilization-of-an-alternative-docetaxel-based-intraperitoneal-chemotherapy-regimen-in-patients-with-ovarian-fallopian-tube-or-primary-peritoneal-carcinoma-a-continued-need-for-ovarian-cancer-patients
#7
David A Becker, Charles A Leath, Christen L Walters-Haygood, Brentley Q Smith, Kerri S Bevis
OBJECTIVE: The objective of this study was to report the tolerability and toxicity of a regimen consisting of intravenous (IV) docetaxel and intraperitoneal (IP) cisplatin and paclitaxel with granulocyte colony-stimulating factor support. MATERIALS AND METHODS: We conducted a retrospective cohort study of patients with surgical stage II-IV epithelial ovarian, fallopian tube or primary peritoneal carcinoma treated with an outpatient IP chemotherapy regimen consisting of docetaxel 75 mg/m IV and cisplatin 75 mg/m IP day 1 followed by paclitaxel 60 mg/m IP day 8 every 21 days...
May 18, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29781940/alpha-actinin-3-r577x-polymorphism-influences-muscle-damage-and-hormonal-responses-after-a-soccer-game
#8
Daniel B Coelho, Eduardo M Pimenta, Izinara C Rosse, Christiano Veneroso, Guilherme De Azambuja Pussieldi, Lenice K Becker, Emerson C Oliveira, Maria R S Carvalho, Emerson Silami-Garcia
Coelho, DB, Pimenta, EM, Rosse, IC, Veneroso, C, Pussieldi, GDA, Becker, LK, De Oliveira, EC, Carvalho, MRS, and Silami-Garcia, E. Alpha-actinin-3 R577X polymorphism influences muscle damage and hormonal responses after a soccer game. J Strength Cond Res XX(X): 000-000, 2018-The purpose of this study was to evaluate indicators of muscle damage and hormonal responses after soccer matches and its relation to alpha-actinin-3 (ACTN3) gene expression (XX vs. RR/RX), considering that the R allele produces alpha-actinin-3 and provides greater muscle strength and power...
May 17, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29781732/role-of-positive-lifestyle-activities-on-mood-cognition-well-being-and-disease-characteristics-in-multiple-sclerosis
#9
Lauren B Strober, Alexandra Becker, John J Randolph
Multiple sclerosis (MS) is a neurological condition associated with a wide variety of physical, cognitive, and mood-related symptoms. While disease-modifying treatment has been shown to reduce the severity and frequency of MS symptom relapses, engagement in certain daily activities holds promise as an adjunctive treatment to better manage disease sequelae. The present study sought to determine whether healthy nutritional choices, exercise, and social/intellectual engagement impacts functioning in individuals with MS...
July 2018: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/29781624/helium-ion-microscopy-as-a-high-resolution-probe-for-complex-quantum-heterostructures-in-core-shell-nanowires
#10
Christian Pöpsel, Jonathan Becker, Nari Jeon, Markus Döblinger, Thomas Stettner, Yeanitza Trujillo Gottschalk, Bernhard Loitsch, Sonja Matich, Marcus Altzschner, Alexander W Holleitner, Jonathan Finley, Lincoln J Lauhon, Gregor Koblmueller
Core-shell semiconductor nanowires (NW) with internal quantum heterostructures are among the most complex nanostructured materials to be explored for assessing the ultimate capabilities of diverse ultrahigh-resolution imaging techniques. To probe the structure and composition of these materials in their native environment with minimal damage and sample preparation calls for high-resolution electron or ion microscopy methods, which have not yet been tested on such classes of ultra-small quantum nanostructures...
May 21, 2018: Nano Letters
https://www.readbyqxmd.com/read/29781087/is-%C3%AE-endorphin-significant-in-the-control-of-the-male-sexual-response
#11
Stefan Ückert, Armin J Becker, Andreas Bannowsky, Christian G Stief, Markus A Kuczyk
It has been assumed that β-endorphin, belonging to the family of opiodergic neuropeptides, might facilitate the inhibition of the male sexual response; however, its role in the control of the penile erectile tissue remains to be elucidated. This study aimed to evaluate in healthy men the course of β-endorphin in the systemic and cavernous blood through different stages of sexual arousal. Thirty-four (34) men were exposed to erotic stimuli to induce penile tumescence and rigidity. Blood was aspirated from the corpus cavernosum and a cubital vein during the penile conditions flaccidity, tumescence, rigidity and detumescence...
May 20, 2018: Andrologia
https://www.readbyqxmd.com/read/29780837/foot-kinematics-differ-between-runners-with-and-without-a-history-of-navicular-stress-fractures
#12
James Becker, Stanley James, Louis Osternig, Li-Shan Chou
Background: A navicular stress fracture (NSF) is a common and high-risk injury in distance runners. It is not clear whether there are differences in foot structure and function between runners who have and those who have not sustained an NSF. Purpose/Hypothesis: This study compared foot structure, range of motion, and biomechanics between runners with a history of unilateral NSFs and runners who had never sustained this injury. The hypothesis was that runners with a history of NSFs will have less dorsiflexion and subtalar range of motion in a clinical examination and greater rearfoot eversion and higher eversion velocity while running than either the noninvolved feet or healthy controls...
April 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29779067/cost-effective-large-scale-expression-of-proteins-for-nmr-studies
#13
Julia Klopp, Aurélie Winterhalter, Rémy Gébleux, Daniela Scherer-Becker, Christian Ostermeier, Alvar D Gossert
We present protocols for high-level expression of isotope-labelled proteins in E. coli in cost-effective ways. This includes production of large amounts of unlabeled proteins and 13 C-methyl methionine labeling in rich media, where yields of up to a gram of soluble protein per liter of culture are reached. Procedures for uniform isotope labeling of 2 H, 13 C and 15 N using auto-induction or isopropyl-β-D-1-thiogalactopyranoside-induction are described, with primary focus on minimal isotope consumption and high reproducibility of protein expression...
May 19, 2018: Journal of Biomolecular NMR
https://www.readbyqxmd.com/read/29778562/comparison-of-tigecycline-susceptibility-testing-methods-for-multidrug-resistant-acinetobacter-baumannii
#14
Evgeny A Idelevich, Dinah A Freeborn, Harald Seifert, Karsten Becker
Automated systems Vitek 2, BD Phoenix, MicroScan WalkAway and gradient diffusion assays Etest and MIC Test Strip were compared against broth microdilution for susceptibility testing of tigecycline against Acinetobacter baumannii. BD Phoenix and MIC Test Strip seemed to provide the most accurate determination of tigecycline susceptibility.
March 24, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29778277/interpretation-of-acid-%C3%AE-glucosidase-activity-in-creatine-kinase-elevation-a-case-of-becker-muscular-dystrophy
#15
Yoshiki Oitani, Akihiko Ishiyama, Motomichi Kosuga, Kentaro Iwasawa, Ayako Ogata, Fumiko Tanaka, Eri Takeshita, Yuko Shimizu-Motohashi, Hirofumi Komaki, Ichizo Nishino, Torayuki Okuyama, Masayuki Sasaki
BACKGROUND: Diagnosis of Pompe disease is sometimes challenging because it exhibits clinical similarities to muscular dystrophy. CASE: We describe a case of Becker muscular dystrophy (BMD) with a remarkable reduction in activity of the acid α-glucosidase (GAA) enzyme, caused by a combination of pathogenic mutation and polymorphism variants resulting in pseudodeficiency in GAA. The three-year-old boy demonstrated asymptomatic creatine kinase elevation. Neither exon deletion nor duplication was detected on multiplex ligation-dependent probe amplification (MLPA) of DMD...
May 16, 2018: Brain & Development
https://www.readbyqxmd.com/read/29777490/comparison-of-the-etiological-relevance-of-staphylococcus-haemolyticus-and-staphylococcus-hominis
#16
Hagen Frickmann, Andreas Hahn, Romy Skusa, Nils Mund, Vivian Viehweger, Thomas Köller, Kerstin Köller, Norbert Georg Schwarz, Karsten Becker, Philipp Warnke, Andreas Podbielski
The study was performed to assess potential differences in the etiological relevance of two coagulase-negative staphylococci (CoNS), Staphylococcus haemolyticus and Staphylococcus hominis, in an observational single-center study. Over a 5-year interval, patients in whom there was detected S. haemolyticus or S. hominis of presumed etiological relevance were assessed for the primary endpoint death during hospital stay and the secondary endpoint transfer to an intensive care unit (ICU) after the detection of S...
May 19, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29776836/analysis-of-incidence-of-traumatic-brain-injury-in-blunt-trauma-patients-with-glasgow-coma-scale-of-12-or-less
#17
Alexander Becker, Kobi Peleg, Oded Olsha, Adi Givon, Boris Kessel
PURPOSE: Early diagnosis of traumatic brain injury (TBI) is important for improving survival and neurologic outcome in trauma victims. The purpose of this study was to assess whether Glasgow Coma Scale (GCS) of 12 or less can predict the presence of TBI and the severity of associated injuries in blunt trauma patients. METHODS: A retrospective cohort study including 303,435 blunt trauma patients who were transferred from the scene to hospital from 1998 to 2013. The data was obtained from the records of the National Trauma Registry maintained by Israel's National Center for Trauma and Emergency Medicine Research, in the Gertner Institute for Epidemiology and Health Policy Research...
April 16, 2018: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29774838/rickettsia-parkeri-in-dermacentor-parumapertus-ticks-mexico
#18
Sokani Sánchez-Montes, Andrés M López-Pérez, Carmen Guzmán-Cornejo, Pablo Colunga-Salas, Ingeborg Becker, Jesús Delgado-de la Mora, Jesús D Licona-Enríquez, David Delgado-de la Mora, Sandor E Karpathy, Christopher D Paddock, Gerardo Suzán
During a study to identify zoonotic pathogens in northwestern Mexico, we detected the presence of a rickettsial agent in Dermacentor parumapertus ticks from black-tailed jackrabbits (Lepus californicus). Comparison of 4 gene sequences (gltA, htrA, ompA, and ompB) of this agent showed 99%-100% identity with sequences of Rickettsia parkeri.
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29773572/hemostatic-efficacy-of-pathogen-inactivated-versus-untreated-platelets-a-randomized-controlled-trial
#19
Pieter F van der Meer, Paula F Ypma, Nan van Geloven, Joost A van Hilten, Rinie J van Wordragen-Vlaswinkel, Okke Eissen, Jaap J Zwaginga, MIchael Trus, Erik A M Beckers, Peter Te Boekhorst, Alan Tinmouth, Yulia Lin, Cyrus Hsia, David Lee, Philip J Norris, Raymond P Goodrich, Anneke Brand, Tor Hervig, Nancy M Heddle, Johanna G van der Bom, Jean-Louis H Kerkhoffs
Pathogen inactivation of platelet concentrates reduces the risk of blood-borne infections. However, its effect on platelet function and hemostatic efficacy of transfusion is unclear. We conducted a randomized noninferiority trial comparing the efficacy of pathogen inactivated platelets using riboflavin and ultraviolet B illumination technology (intervention) compared to standard plasma-stored platelets (control) for the prevention of bleeding in patients with hematologic malignancies and thrombocytopenia. The primary outcome parameter was the proportion of transfusion treatment periods in which the patient had grade 2 or higher bleeding as defined by World Health Organization (WHO) criteria...
May 17, 2018: Blood
https://www.readbyqxmd.com/read/29772734/high-pressure-treatment-of-non-hydrated-flour-affects-structural-characteristics-and-hydration
#20
Sabina Jakobi, Mario Jekle, Thomas Becker
In recent years, high-pressure treatment (HPT) has become an established process concerning the preservation of food. However, studies dealing with the structural, and consequently functional modification of non-hydrated starchy matrices (moisture content ≤ 15%) by HPT are missing. To close this knowledge gap, pressure (0⁻600 MPa, 10 min) and pressurization time depending (0⁻20 min, 450 MPa) alterations of wheat flour were investigated. Pressure rise from 0 to 600 MPa or pressurization time rise from 0 to 20 min resulted in a decline of amylopectin content from 68...
May 16, 2018: Foods (Basel, Switzerland)
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