Fulvia Ceccarelli, Francesco Natalucci, Licia Picciariello, Alessio Cirillo, Giulio Olivieri, Margherita Veroli, Simona Pisegna, Claudia Ciancarella, Alain Gelibter, Vincenzo Picone, Daniele Santini, Andrea Botticelli, Fabrizio Conti
We aim at investigating the association between subclinical autoimmunity and immune-related adverse events (irAEs) in a cohort of patients treated by immune checkpoint inhibitors for solid metastatic cancer. In the context of an oncology/rheumatology outpatient clinic, we evaluated patients treated with anti-PD-1 or anti-PD-L1. Before treatment, each patient underwent a physical evaluation and a blood sample to identify the presence of a set of autoantibodies. Indeed, all the patients were followed during treatment to identify irAEs and to assess the association with autoantibodies...
April 10, 2024: Clinical and Experimental Medicine