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https://www.readbyqxmd.com/read/29140225/key-patterns-and-predictors-of-response-to-treatment-for-military-veterans-with-post-traumatic-stress-disorder-a-growth-mixture-modelling-approach
#1
A J Phelps, Z Steel, O Metcalf, N Alkemade, K Kerr, M O'Donnell, J Nursey, J Cooper, A Howard, R Armstrong, D Forbes
BACKGROUND: To determine the patterns and predictors of treatment response trajectories for veterans with post-traumatic stress disorder (PTSD). METHODS: Conditional latent growth mixture modelling was used to identify classes and predictors of class membership. In total, 2686 veterans treated for PTSD between 2002 and 2015 across 14 hospitals in Australia completed the PTSD Checklist at intake, discharge, and 3 and 9 months follow-up. Predictor variables included co-morbid mental health problems, relationship functioning, employment and compensation status...
November 15, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29126430/lack-of-chronic-neuroinflammation-in-the-absence-of-focal-hemorrhage-in-a-rat-model-of-low-energy-blast-induced-tbi
#2
Miguel A Gama Sosa, Rita De Gasperi, Georgina S Perez Garcia, Heidi Sosa, Courtney Searcy, Danielle Vargas, Pierce L Janssen, Gissel M Perez, Anna E Tschiffely, William G Janssen, Richard M McCarron, Patrick R Hof, Fatemeh G Haghighi, Stephen T Ahlers, Gregory A Elder
Blast-related traumatic brain injury (TBI) has been a common cause of injury in the recent conflicts in Iraq and Afghanistan. Blast waves can damage blood vessels, neurons, and glial cells within the brain. Acutely, depending on the blast energy, blast wave duration, and number of exposures, blast waves disrupt the blood-brain barrier, triggering microglial activation and neuroinflammation. Recently, there has been much interest in the role that ongoing neuroinflammation may play in the chronic effects of TBI...
November 10, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/29124416/prevalence-and-correlates-of-health-information-seeking-among-hispanic-and-non-hispanic-childhood-cancer-survivors
#3
Kimberly A Miller, Cynthia N Ramirez, Katherine Y Wojcik, Anamara Ritt-Olson, Lourdes Baezconde-Garbanati, Stefanie M Thomas, David R Freyer, Ann S Hamilton, Joel E Milam
PURPOSE: Childhood cancer survivors (CCS) report high unmet information needs. This study examined the prevalence of cancer-related information-seeking among CCS and investigated associations between information-seeking behavior and positive health outcomes such as follow-up care. METHODS: Participants (n = 193) were young adult CCS diagnosed with cancer in Los Angeles County, 54% of Hispanic ethnicity, with a mean age of 19.87, in remission, and at least 2 years from completion of treatment...
November 9, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29108471/intranasally-delivered-wnt3a-improves-functional-recovery-after-traumatic-brain-injury-by-modulating-autophagic-apoptotic-and-regenerative-pathways-in-the-mouse-brain
#4
James Ya Zhang, Jinhwan Lee, Xiaohuan Gu, Zheng Wei, Mallory Jessica Harris, Shan Ping P Yu, Ling Wei
Traumatic brain injury (TBI) is a prevalent disorder, but no effective therapies currently exist. An underlying pathophysiology of TBI includes the pathologic elevation of autophagy. β-Catenin, a downstream mediator of the canonical Wnt pathway, is a repressor of autophagy. The Wnt/β-catenin pathway plays a crucial role in cell proliferation and neuronal plasticity/repair in the adult brain. We hypothesized that activation of this pathway could promote neuroprotection and neural regeneration following TBI...
November 6, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29107133/physeal-fractures-of-the-lower-leg-in-children-and-adolescents-therapeutic-results-pitfalls-and-suggested-management-protocol-based-on-the-experience-of-the-authors-and-contemporary-literature
#5
Marcin Karlikowski, Jerzy Sułko
INTRODUCTION: Physeal fractures in children frequently give rise to concerns about the condition of the growth plate. Our observations have proven that the dysfunction of the growth plate is less frequent complication in those cases than misdiagnosed interposition of the periosteum. The aim of this paper is to familiarize the readers with the issue of treatment of physeal fractures of the distal tibia and fibula in the growing skeleton. MATERIALS AND METHODS: We analyzed the group of 75 patients - children and adolescents - with surgically treated physeal fractures of the lower leg...
October 26, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29103821/the-impact-of-cytokine-responses-in-the-intra-and-extracellular-signaling-network-of-a-traumatic-injury
#6
Alice A Han, Holly N Currie, Matthew S Loos, Giovanni Scardoni, Julie V Miller, Nicole Prince, Julia A Mouch, Jonathan W Boyd
Investigations of cellular responses involved in injury and repair processes have generated valuable information contributing to the advancement of wound healing and treatments. Intra- and extracellular regulators of healing mechanisms, such as cytokines, signaling proteins, and growth factors, have been described to possess significant roles in facilitating optimal recovery. This study explored a collection of 30 spatiotemporal responses comprised of cytokines (IL-1α, IL-1ß, IL-2, IL-6, TNF-α, MIP-1α), intracellular proteins (Akt, c-Jun, CREB, ERK1/2, JNK, MEK1, p38, p53, p90RSK), phosphorylated proteins (p-Akt, p-c-Jun, p-CREB, p-ERK1/2, p-GSK-3α/ß, p-HSP27, p-IκBα, p-JNK, p-MEK1, p-p38, p-p70S6K, p-p90RSK, p-STAT2, p-STAT3), and a protease (Caspase-3), measured in skeletal muscle tissue following a traumatic injury (rodent Gustilo IIIB fracture)...
November 2, 2017: Cytokine
https://www.readbyqxmd.com/read/29096418/correlates-of-post-traumatic-growth-following-childhood-and-adolescent-cancer-a-systematic-review-and-meta-analysis
#7
REVIEW
Jasmin K Turner, Amanda Hutchinson, Carlene Wilson
OBJECTIVE: Post-traumatic growth is defined as positive change resulting from the struggle with highly challenging life circumstances or trauma [1]. A growing number of children and adolescents are experiencing and surviving cancer. This review aims to identify the demographic, medical, and psychosocial correlates of perceived post-traumatic growth in individuals of any age who were affected by paediatric cancer. Findings will highlight protective factors that may facilitate post-traumatic growth, allowing for directed social support, intervention, and follow-up care...
November 2, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29095270/pituitary-insufficiency-following-traumatic-thoracic-injury-in-an-adolescent-male-patient-a-case-report-and-literature-review
#8
REVIEW
Aleksandra Gilis-Januszewska, Łukasz Kluczyński, Małgorzata Wilusz, Jacek Pantofliński, Renata Turek-Jabrocka, Dorota Pach, Alicja Hubalewska-Dydejczyk
RATIONALE: Traumatic thoracic injuries in adolescents are rare but could be connected with traumatic brain injuries (TBI) and development of chronic hypopituitarism. Early recognition of these endocrine problems is a significant challenge to clinicians. We present difficulties in diagnosis of hypothalamic-pituitary insufficiency following traumatic thoracic injury in adolescence. We also review the literature of similar cases. PATIENT CONCERNS: We present a case of a 24-years-old male...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29075319/a-qualitative-analysis-of-psychosocial-outcomes-among-women-with-sexual-violence-related-pregnancies-in-eastern-democratic-republic-of-congo
#9
Jennifer Scott, Colleen Mullen, Shada Rouhani, Philipp Kuwert, Ashley Greiner, Katherine Albutt, Gillian Burkhardt, Monica Onyango, Michael VanRooyen, Susan Bartels
BACKGROUND: Sexual violence is prevalent in eastern Democratic Republic of Congo (DRC) and has potentially devastating psychosocial consequences. Previous studies have reported on sexual violence and its impact on the mental health of survivors, but there are few studies conducted among women with sexual violence-related pregnancies (SVRPs). Women with SVRPs may be at greater risk of complex psychosocial outcomes, including social stigmatization. This study aimed to describe psychosocial outcomes among this subgroup of sexual violence survivors in order to inform future interventions...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/29074420/effect-of-tranexamic-acid-on-prevention-of-hemorrhagic-mass-growth-in-patients-with-traumatic-brain-injury
#10
Esmaeil Fakharian, Masoumeh Abedzadeh-Kalahroudi, Fatemeh Atoof
BACKGROUND: Intracranial hemorrhage (ICH) is a common complication of traumatic brain injury (TBI). The purpose of this study is evaluation of the effect of Tranexamic Acid (TXA) on hemorrhagic mass growth in TBI patients. PATIENTS AND METHODS: In this randomized double blind clinical trial, 149 patients with TBI and any kind of blood on their CT scan, enrolled to the study and randomly allocated to receiving TXA or placebo. After 24 hours, CT scan was repeated for assessing the changes in hemorrhage, new bleeding, and mass effects of the blood on the brain tissue...
October 23, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29073743/eye-movement-desensitization-and-reprocessing-to-facilitate-posttraumatic-growth-a-prospective-clinical-pilot-study-on-ferry-disaster-survivors
#11
Sang Won Jeon, Changsu Han, Joonho Choi, Young-Hoon Ko, Ho-Kyoung Yoon, Yong-Ku Kim
Objective: The purpose of this study was to investigate the therapeutic effects of eye movement desensitization and reprocessing (EMDR) on post-traumatic growth (PTG). Methods: This study was conducted using a sample of ten survivors of a large-scale maritime disaster that occurred in the Yellow Sea, South Korea, in April 2014. A total of eight EMDR sessions were administered by a psychiatrist at two-week intervals over a period of five months, starting two or three months after the accident...
November 30, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29036483/a-decade-of-war-prospective-trajectories-of-post-traumatic-stress-disorder-symptoms-among-deployed-us-military-personnel-and-the-influence-of-combat-exposure
#12
Carrie J Donoho, George A Bonanno, Ben Porter, Lauren Kearney, Teresa M Powell
Post-traumatic stress disorder (PTSD) is a common psychiatric disorder among service members and veterans. The clinical course of PTSD varies across individuals, and patterns of symptom development have yet to be clearly delineated. Previous studies have been limited by convenience sampling, short follow-up periods, and inability to account for combat-related trauma. To determine the trajectories of PTSD symptoms among deployed military personnel with and without combat exposure, we used data from a population-based representative sample of 8,178 US service members participating in the Millennium Cohort Study from 2001-2011...
September 27, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29035733/how-does-parental-cancer-affect-adolescent-and-young-adult-offspring-a-systematic-review
#13
REVIEW
Adam Walczak, Fiona McDonald, Pandora Patterson, Katherine Dobinson, Kimberley Allison
OBJECTIVES: To i) identify and synthesise evidence published since 2007 regarding the impact of parental cancer on adolescent and young adult offspring, ii) identify methodological and evidence gaps addressed during this period and iii) highlight those requiring further attention. DESIGN: A systematic review and thematic synthesis of peer reviewed literature regarding the impact of parental cancer upon AYA offspring. DATA SOURCES: Online searches of CINAHL, Embase, Medline, PsychInfo and Scopus databases were conducted...
September 1, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29026147/vascular-endothelial-growth-factor-in-cartilage-development-and-osteoarthritis
#14
Masashi Nagao, John L Hamilton, Ranjan Kc, Agnes D Berendsen, Xuchen Duan, Chan Wook Cheong, Xin Li, Hee-Jeong Im, Bjorn R Olsen
Genome wide studies indicate that vascular endothelial growth factor A (VEGF) is associated with osteoarthritis (OA), and increased VEGF expression correlates with increased disease severity. VEGF is also a chondrocyte survival factor during development and essential for bone formation, skeletal growth and postnatal homeostasis. This raises questions of how the important embryonic and postnatal functions of VEGF can be reconciled with an apparently destructive role in OA. Addressing these questions, we find that VEGF acts as a survival factor in growth plate chondrocytes during development but only up until a few weeks after birth in mice...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28982680/chronic-psychosocial-stress-disturbs-long-bone-growth-in-adolescent-mice
#15
S Foertsch, M Haffner-Luntzer, J Kroner, F Gross, K Kaiser, M Erber, S O Reber, A Ignatius
Although a strong association between psychiatric and somatic disorders is generally accepted, little is known regarding the interrelation between mental and skeletal health. While depressive disorders were shown to be strongly associated with osteoporosis and increased fracture risk, evidence from post-traumatic stress disorder (PTSD) patients is less consistent. Therefore, the present study investigated the influence of chronic psychosocial stress on bone using a well-established murine model for PTSD. 7-week-old C57BL/6N mice were subjected to chronic subordinate colony housing (CSC) for 19 days, whereas control mice were singly housed...
October 5, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28939348/transcranial-ultrasound-stimulation-promotes-brain-derived-neurotrophic-factor-and-reduces-apoptosis-in-a-mouse-model-of-traumatic-brain-injury
#16
Wei-Shen Su, Chun-Hu Wu, Szu-Fu Chen, Feng-Yi Yang
BACKGROUND: The protein expressions of brain-derived neurotrophic factor (BDNF) can be elevated by transcranial ultrasound stimulation in the rat brain. OBJECTIVE: The purpose of this study was to investigate the effects and underlying mechanisms of BDNF enhancement by low-intensity pulsed ultrasound (LIPUS) on traumatic brain injury (TBI). METHODS: Mice subjected to controlled cortical impact injury were treated with LIPUS in the injured region daily for a period of 4 days...
September 7, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28924363/thrombospondin-1-gene-deficiency-worsens-the-neurological-outcomes-of-traumatic-brain-injury-in-mice
#17
Chongjie Cheng, Zhanyang Yu, Song Zhao, Zhengbu Liao, Changhong Xing, Yinghua Jiang, Yong-Guang Yang, Michael J Whalen, Eng H Lo, Xiaochuan Sun, Xiaoying Wang
Background: Thrombospondin-1 (TSP-1) is an extracellular matrix protein that plays multiple physiological and pathophysiological roles in the brain. Experimental reports suggest that TSP-1 may have an adverse role in neuronal function recovery under certain injury conditions. However, the roles of TSP-1 in traumatic brain injury (TBI) have not been elucidated. In this study we for the first time investigated the roles of TSP-1 in a controlled cortical impact (CCI) model of TBI in TSP-1 knockout (TSP-1 KO) and wild type (WT) mice...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28918413/post-traumatic-growth-and-its-relationship-to-quality-of-life-up-to-9-years-after-liver-transplantation-a-cross-sectional-study-in-spain
#18
María Ángeles Pérez-San-Gregorio, Agustín Martín-Rodríguez, Mercedes Borda-Mas, María Luisa Avargues-Navarro, José Pérez-Bernal, Rupert Conrad, Miguel Ángel Gómez-Bravo
OBJECTIVE: Little is known concerning post-traumatic growth (PTG) after liver transplantation. Against this backdrop the current study analysed the relationship between PTG and time since transplantation on quality of life. Furthermore, it compared PTG between liver transplant recipients and their caregivers. DESIGN: Cross-sectional case-control study. SETTING: University Hospital in Spain. PARTICIPANTS: 240 adult liver transplant recipients who had undergone only one transplantation, with no severe mental disease, were the participants of the study...
September 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28917187/trajectories-of-post-traumatic-stress-and-externalizing-psychopathology-among-maltreated-foster-care-youth-a-parallel-process-latent-growth-curve-model
#19
Gia Elise Barboza, Silvia Dominguez, Jyda Pinder
Few longitudinal studies have analyzed how violence exposure (e.g. child maltreatment, witnessing community violence) influence both externalizing and Post-Traumatic Stress (PTS) symptoms among children in foster care. Data from three waves of the National Survey of Child and Adolescent Well-Being (1999-2007) (NSCAW; National Data Archive on Child Abuse and Neglect, 2002) were analyzed to investigate the change trajectories of both externalizing and PTS symptomatology among children with a substantiated report of child maltreatment by Child Protective Services (CPS) between October 1999 and December 2000...
October 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28913683/an-evidence-map-of-the-women-veterans-health-research-literature-2008-2015
#20
Elisheva R Danan, Erin E Krebs, Kristine Ensrud, Eva Koeller, Roderick MacDonald, Tina Velasquez, Nancy Greer, Timothy J Wilt
BACKGROUND: Women comprise a growing proportion of Veterans seeking care at Veterans Affairs (VA) healthcare facilities. VA initiatives have accelerated changes in services for female Veterans, yet the corresponding literature has not been systematically reviewed since 2008. In 2015, VA Women's Health Services and the VA Women's Health Research Network requested an updated literature review to facilitate policy and research planning. METHODS: The Minneapolis VA Evidence-based Synthesis Program performed a systematic search of research related to female Veterans' health published from 2008 through 2015...
September 14, 2017: Journal of General Internal Medicine
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