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https://www.readbyqxmd.com/read/29334295/neuritin-provides-neuroprotection-against-experimental-traumatic-brain-injury-in-rats
#1
Qi Liu, Hang Zhang, Jian Xu, Dong Zhao
Objectives Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Neuritin is a neurotrophic factor that regulates neural growth and development. However, the role of neuritin in alleviating TBI has not been investigated. Methods In this study, Sprague Dawley rats (n = 144) weighing 300 ± 50 g were categorized into control, sham, TBI, and TBI + neuritin groups. The neurological scores and the ultrastructure of cortical neurons, apoptotic cells, and caspase-3 were measured by using Garcia scoring system, transmission electron microscopy, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling, Western blot analysis, and real-time RT-PCR at various time points post-TBI...
January 15, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29332015/post-traumatic-stress-and-growth-among-cpr-survivors-in-the-southeast-of-iran
#2
Seyed Hamid Seyed Bagheri, Sedigheh Iranmanesh, Masoud Rayyani, Mahlagha Dehghan, Batool Tirgari, Seyed Habibollah Hosseini
Background Almost 7.2%-10.6% of patients survive CPR in Iran. Most of them experience post-traumatic stress disorder (PTSD) and post-traumatic growth (PTG). There are limited studies to assessing the correlation between these two psychological outcomes among CPR survivors. Objective This study aimed to examine the correlation between PTSD and PTG among CPR survivors in South-East Iran. Subjects Using Quota sampling, 163 CPR survivors in two provinces in the South-East of Iran were selected to participate in this study...
January 13, 2018: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29274773/nerve-growth-factor-plays-a-role-in-the-neurotherapeutic-effect-of-a-cd45-pan-hematopoietic-subpopulation-derived-from-human-umbilical-cord-blood-in-a-traumatic-brain-injury-model
#3
Galit Gincberg, Esther Shohami, Victoria Trembovler, Alexander G Alexandrovich, Philip Lazarovici, Uriel Elchalal
BACKGROUND AIMS: Human umbilical cord blood (HUCB) is an important source of stem cells for therapy of hematopoietic disorders and is a potential therapy for various neurological disorders, including traumatic brain injury (TBI). The expression of nerve growth factor (NGF) and its receptors TrkA, p75NTR and α9β1 integrin on an HUCB CD45+ pan-hematopoietic subpopulation was investigated in the context of its neurotherapeutic potential after TBI. METHODS: NGF and its receptors were detected on CD45+ cells by reverse transcriptase polymerase chain reaction, flow cytometry analysis and confocal microscopy...
February 2018: Cytotherapy
https://www.readbyqxmd.com/read/29251706/valproic-acid-induces-pro-survival-transcriptomic-changes-in-swine-subjected-to-traumatic-injury-and-hemorrhagic-shock
#4
Patrick E Georgoff, Vahagn C Nikolian, Gerald Higgins, Kiril Chtraklin, Hassan Eidy, Mohamed H Ghandour, Aaron Williams, Brian Athey, Hasan B Alam
BACKGROUND: Valproic acid (VPA) is a histone deacetylase inhibitor that improves outcomes in large animal models of trauma. However, its protective mechanism of action is not completely understood. We sought to characterize the genetic changes induced by VPA treatment following traumatic injuries. METHODS: Six female Yorkshire swine were subjected to traumatic brain injury (TBI, controlled cortical impact), polytrauma (liver and splenic laceration, rib fracture, rectus crush), and hemorrhagic shock (HS, 40% total blood volume)...
December 14, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29250157/myrtol-improves-post-traumatic-knee-osteoarthritis-by-regulation-of-reactive-oxygen-species-transforming-growth-factor-%C3%AE-1-and-apoptosis-in-a-mouse-model
#5
Liqun Duan, Wenzhi Zhang, Feng Zhang, Haiping Cai
The present study tested whether myrtol improves post-traumatic knee osteoarthritis (PTKO) by regulating the reactive oxygen species (ROS), transforming growth factor β1 (TGF-β1) and apoptosis in a mouse model. PTKO model mice were administered with 150, 300 or 450 mg/kg myrtol for 8 weeks. ELISA analysis was used to measure tumor necrosis factor-α, interleukin-6, malondialdehyde, superoxide dismutase, reactive oxygen species and TGF-β1 levels. Caspase-3 and Bax protein expressions were analyzed using western blot analysis...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29248901/can-living-in-the-shadow-of-terror-leave-no-marks-long-term-effects-of-traumatic-environments-of-varying-intensity
#6
Yarden Mendelson, Eytan Bachar, Aaron Cherniak, Rena Cooper-Kazaz
INTRODUCTION: This study investigated the long-term effects of different traumatic environments on adolescents. Environments were characterized by different threats that varied in predictability, duration, and the extent to which the threat can be defended against. The research examined: 1) Jerusalem during the Second Intifada (2001-2004), 2) Israel's northern cities during the Second Lebanon War (2006), and 3) cities that suffered neither the suicide bombings (that occurred in Jerusalem) nor the rocket bombardments (that occurred in the north)...
2017: Israel Journal of Psychiatry and related Sciences
https://www.readbyqxmd.com/read/29227174/gambogic-amide-a-selective-trka-agonist-does-not-improve-outcomes-from-traumatic-brain-injury-in-mice
#7
Maddison R Johnstone, Mujun Sun, Caroline J Taylor, Rhys D Brady, Brian L Grills, Jarrod E Church, Sandy R Shultz, Stuart J McDonald
OBJECTIVES: There is evidence that treatment with nerve growth factor (NGF) may reduce neuroinflammation and apoptosis after a traumatic brain injury (TBI). NGF is thought to exert its effects via binding to either TrkA or p75 neurotrophin receptors. This study aimed to investigate the effects of a selective TrkA agonist, gambogic amide (GA), on TBI pathology and outcomes in mice following lateral fluid percussion injury. METHODS: Male C57BL/6 mice were given either a TBI or sham injury, and then received subcutaneous injections of either 2 mg/kg of GA or vehicle at 1, 24, and 48 h post-injury...
December 11, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29224518/grief-as-a-mystical-journey-fowler-s-stages-of-faith-development-and-their-relation-to-post-traumatic-growth
#8
Terri Daniel
This paper explores the relationship between embedded theological assumptions and the ways in which one copes with loss and bereavement. Based on James Fowler's research on Stages of Faith Development, the paper examines common Western psycho-spiritual beliefs related to loss, trauma, and grief, and proposes that profound loss experiences have the potential to lead the griever to a shift in theological thinking. It addresses the ways in which a "crisis of faith" triggered by loss or trauma prompts the questioning of closely-held beliefs, which can lead to an expanded spiritual perspective that can be beneficial to the healing process...
December 2017: Journal of Pastoral Care & Counseling: JPCC
https://www.readbyqxmd.com/read/29207475/function-of-micrornas-in-the-osteogenic-differentiation-and-therapeutic-application-of-adipose-derived-stem-cells-ascs
#9
REVIEW
Walter M Hodges, Frederick O'Brien, Sadanand Fulzele, Mark W Hamrick
Traumatic wounds with segmental bone defects represent substantial reconstructive challenges. Autologous bone grafting is considered the gold standard for surgical treatment in many cases, but donor site morbidity and associated post-operative complications remain a concern. Advances in regenerative techniques utilizing mesenchymal stem cell populations from bone and adipose tissue have opened the door to improving bone repair in the limbs, spine, and craniofacial skeleton. The widespread availability, ease of extraction, and lack of immunogenicity have made adipose-derived stem cells (ASCs) particularly attractive as a stem cell source for regenerative strategies...
December 2, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29192184/affective-emotion-increases-heart-rate-variability-and-activates-left-dorsolateral-prefrontal-cortex-in-post-traumatic-growth
#10
Chuguang Wei, Jin Han, Yuqing Zhang, Walter Hannak, Yanyan Dai, Zhengkui Liu
The present study evaluated the activities of heart rate variability (HRV) and dorsolateral prefrontal cortex (DLPFC) in response to the presentation of affective pictures correlated with posttraumatic growth (PTG) among adults exposed to the Tianjin explosion incident. The participants who were directly involved in the Tianjin explosions were divided into control, post-traumatic stress disorder (PTSD) and PTG group according to the scores of PTSD Checklist-Civilian Version and PTG Inventory survey. All participants received exposure to affective images...
November 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29190463/genipin-treated-chitosan-nanofibers-as-a-novel-scaffold-for-nerve-guidance-channel-design
#11
Yu-Ting Lau, Lam-Fung Kwok, Kin-Wai Tam, Ying-Shing Chan, Daisy Kwok-Yan Shum, Graham Ka-Hon Shea
Schwann cell-seeded nerve guidance channels are designed to assist post-traumatic nerve regeneration in the PNS. Chitosan is a natural polymer well suited for tissue engineering as it is biocompatible, non-immunogenic, and biodegradable. Electrospun chitosan nanofibers utilized in nerve guidance channels have the capacity for guiding axonal growth within the channel lumen yet are limited in their capacity to maintain structural integrity within physiological environments. To address this, we attempted genipin crosslinking of chitosan nanofibers...
November 23, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29188680/biomaterials-as-bone-graft-substitutes-for-spine-surgery-from-preclinical-results-to-clinical-study
#12
G Barbanti Bròdano, C Griffoni, A Nataloni, M Manfrini, G Giavaresi, S Bandiera, A Gasbarrini, S Terzi, R Ghermandi, G Tedesco, M Girolami, M Tognon, M Fini
Vertebral fusion is performed in order to stabilize the spine in the presence of degenerative, traumatic or oncological pathologies that alter its stability. The autologous bone, harvested from the patient’s iliac crest or from the lamina during surgery, is still considered the “gold standard” for spine fusion due to its osteogenic, osteoinductive and osteoconductive properties. However, several biological and synthetic bone substitutes have been introduced as alternatives for regenerating bone tissue...
October 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29187730/genome-wide-analysis-in-uk-biobank-identifies-four-loci-associated-with-mood-instability-and-genetic-correlation-with-major-depressive-disorder-anxiety-disorder-and-schizophrenia
#13
Joey Ward, Rona J Strawbridge, Mark E S Bailey, Nicholas Graham, Amy Ferguson, Donald M Lyall, Breda Cullen, Laura M Pidgeon, Jonathan Cavanagh, Daniel F Mackay, Jill P Pell, Michael O'Donovan, Valentina Escott-Price, Daniel J Smith
Mood instability is a core clinical feature of affective and psychotic disorders. In keeping with the Research Domain Criteria approach, it may be a useful construct for identifying biology that cuts across psychiatric categories. We aimed to investigate the biological validity of a simple measure of mood instability and evaluate its genetic relationship with several psychiatric disorders, including major depressive disorder (MDD), bipolar disorder (BD), schizophrenia, attention deficit hyperactivity disorder (ADHD), anxiety disorder and post-traumatic stress disorder (PTSD)...
November 30, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29180963/spinal-cord-molecular-and-cellular-changes-induced-by-adenoviral-vector-and-cell-mediated-triple-gene-therapy-after-severe-contusion
#14
Andrei A Izmailov, Tatyana V Povysheva, Farid V Bashirov, Mikhail E Sokolov, Filip O Fadeev, Ravil R Garifulin, Boris S Naroditsky, Denis Y Logunov, Ilnur I Salafutdinov, Yuri A Chelyshev, Rustem R Islamov, Igor A Lavrov
The gene therapy has been successful in treatment of spinal cord injury (SCI) in several animal models, although it still remains unavailable for clinical practice. Surprisingly, regardless the fact that multiple reports showed motor recovery with gene therapy, little is known about molecular and cellular changes in the post-traumatic spinal cord following viral vector- or cell-mediated gene therapy. In this study we evaluated the therapeutic efficacy and changes in spinal cord after treatment with the genes encoding vascular endothelial growth factor (VEGF), glial cell-derived neurotrophic factor (GDNF), angiogenin (ANG), and neuronal cell adhesion molecule (NCAM) applied using both approaches...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29171105/effects-of-a-family-support-programme-for-pregnant-women-with-foetal-abnormalities-requiring-pregnancy-termination-a-randomized-controlled-trial-in-china
#15
Shiwen Sun, Junqin Li, Yuanying Ma, Huilian Bu, Qiong Luo, Xiaoyan Yu
AIM: We examined the effects of a family-support programme for pregnant women with foetal abnormalities in terms of family support, depression, and post-traumatic stress symptoms. METHOD: A randomized controlled trial was conducted from November 2016 to June 2017. A total of 124 pregnant women with foetal abnormalities were recruited and randomly assigned to the intervention group that received a family-support programme or control group that received only routine care...
November 24, 2017: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/29163253/coping-with-childbirth-brain-structural-associations-of-personal-growth-initiative
#16
Judith Mangelsdorf
Major life events require psychological adaptations and can be accompanied by brain structural and functional changes. The goal of the current study was to investigate the association of personal growth initiative (PGI) as a form of proactive coping strategy before childbirth, with gray matter volume after delivery. Childbirth is one of the few predictable major life events, which, while being one of the most positive experiences for many, is also accompanied by multidimensional stress for the mother. Previous research has shown that high stress is associated with reductions in gray matter volume in limbic cortices as well as the prefrontal cortex (PFC)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29145788/quality-of-life-following-treatment-for-ptsd-comparison-of-videoconferencing-and-in-person-modalities
#17
Lisa H Glassman, Margaret-Anne Mackintosh, Alexander Talkovsky, Stephanie Y Wells, Kristen H Walter, Induni Wickramasinghe, Leslie A Morland
Introduction Quality of life (QOL) is significantly impaired among individuals with post-traumatic stress disorder (PTSD); however, few treatment outcome studies examine QOL following treatment. Furthermore, the use of videoconferencing to deliver evidence-based treatments for PTSD is increasing dramatically. Although videoconferencing has demonstrated non-inferiority to in-person treatment modalities for improving PTSD symptom severity, no studies to date have directly compared QOL outcomes of an evidence-based intervention delivered via videoconferencing to one delivered in-person...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/29140225/key-patterns-and-predictors-of-response-to-treatment-for-military-veterans-with-post-traumatic-stress-disorder-a-growth-mixture-modelling-approach
#18
A J Phelps, Z Steel, O Metcalf, N Alkemade, K Kerr, M O'Donnell, J Nursey, J Cooper, A Howard, R Armstrong, D Forbes
BACKGROUND: To determine the patterns and predictors of treatment response trajectories for veterans with post-traumatic stress disorder (PTSD). METHODS: Conditional latent growth mixture modelling was used to identify classes and predictors of class membership. In total, 2686 veterans treated for PTSD between 2002 and 2015 across 14 hospitals in Australia completed the PTSD Checklist at intake, discharge, and 3 and 9 months follow-up. Predictor variables included co-morbid mental health problems, relationship functioning, employment and compensation status...
November 15, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29126430/lack-of-chronic-neuroinflammation-in-the-absence-of-focal-hemorrhage-in-a-rat-model-of-low-energy-blast-induced-tbi
#19
Miguel A Gama Sosa, Rita De Gasperi, Georgina S Perez Garcia, Heidi Sosa, Courtney Searcy, Danielle Vargas, Pierce L Janssen, Gissel M Perez, Anna E Tschiffely, William G Janssen, Richard M McCarron, Patrick R Hof, Fatemeh G Haghighi, Stephen T Ahlers, Gregory A Elder
Blast-related traumatic brain injury (TBI) has been a common cause of injury in the recent conflicts in Iraq and Afghanistan. Blast waves can damage blood vessels, neurons, and glial cells within the brain. Acutely, depending on the blast energy, blast wave duration, and number of exposures, blast waves disrupt the blood-brain barrier, triggering microglial activation and neuroinflammation. Recently, there has been much interest in the role that ongoing neuroinflammation may play in the chronic effects of TBI...
November 10, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/29124416/prevalence-and-correlates-of-health-information-seeking-among-hispanic-and-non-hispanic-childhood-cancer-survivors
#20
Kimberly A Miller, Cynthia N Ramirez, Katherine Y Wojcik, Anamara Ritt-Olson, Lourdes Baezconde-Garbanati, Stefanie M Thomas, David R Freyer, Ann S Hamilton, Joel E Milam
PURPOSE: Childhood cancer survivors (CCS) report high unmet information needs. This study examined the prevalence of cancer-related information-seeking among CCS and investigated associations between information-seeking behavior and positive health outcomes such as follow-up care. METHODS: Participants (n = 193) were young adult CCS diagnosed with cancer in Los Angeles County, 54% of Hispanic ethnicity, with a mean age of 19.87, in remission, and at least 2 years from completion of treatment...
November 9, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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