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https://www.readbyqxmd.com/read/28924363/thrombospondin-1-gene-deficiency-worsens-the-neurological-outcomes-of-traumatic-brain-injury-in-mice
#1
Chongjie Cheng, Zhanyang Yu, Song Zhao, Zhengbu Liao, Changhong Xing, Yinghua Jiang, Yong-Guang Yang, Michael J Whalen, Eng H Lo, Xiaochuan Sun, Xiaoying Wang
Background: Thrombospondin-1 (TSP-1) is an extracellular matrix protein that plays multiple physiological and pathophysiological roles in the brain. Experimental reports suggest that TSP-1 may have an adverse role in neuronal function recovery under certain injury conditions. However, the roles of TSP-1 in traumatic brain injury (TBI) have not been elucidated. In this study we for the first time investigated the roles of TSP-1 in a controlled cortical impact (CCI) model of TBI in TSP-1 knockout (TSP-1 KO) and wild type (WT) mice...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28918413/post-traumatic-growth-and-its-relationship-to-quality-of-life-up-to-9-years-after-liver-transplantation-a-cross-sectional-study-in-spain
#2
María Ángeles Pérez-San-Gregorio, Agustín Martín-Rodríguez, Mercedes Borda-Mas, María Luisa Avargues-Navarro, José Pérez-Bernal, Rupert Conrad, Miguel Ángel Gómez-Bravo
OBJECTIVE: Little is known concerning post-traumatic growth (PTG) after liver transplantation. Against this backdrop the current study analysed the relationship between PTG and time since transplantation on quality of life. Furthermore, it compared PTG between liver transplant recipients and their caregivers. DESIGN: Cross-sectional case-control study. SETTING: University Hospital in Spain. PARTICIPANTS: 240 adult liver transplant recipients who had undergone only one transplantation, with no severe mental disease, were the participants of the study...
September 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28917187/trajectories-of-post-traumatic-stress-and-externalizing-psychopathology-among-maltreated-foster-care-youth-a-parallel-process-latent-growth-curve-model
#3
Gia Elise Barboza, Silvia Dominguez, Jyda Pinder
Few longitudinal studies have analyzed how violence exposure (e.g. child maltreatment, witnessing community violence) influence both externalizing and Post-Traumatic Stress (PTS) symptoms among children in foster care. Data from three waves of the National Survey of Child and Adolescent Well-Being (1999-2007) (NSCAW; National Data Archive on Child Abuse and Neglect, 2002) were analyzed to investigate the change trajectories of both externalizing and PTS symptomatology among children with a substantiated report of child maltreatment by Child Protective Services (CPS) between October 1999 and December 2000...
September 13, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28913683/an-evidence-map-of-the-women-veterans-health-research-literature-2008-2015
#4
Elisheva R Danan, Erin E Krebs, Kristine Ensrud, Eva Koeller, Roderick MacDonald, Tina Velasquez, Nancy Greer, Timothy J Wilt
BACKGROUND: Women comprise a growing proportion of Veterans seeking care at Veterans Affairs (VA) healthcare facilities. VA initiatives have accelerated changes in services for female Veterans, yet the corresponding literature has not been systematically reviewed since 2008. In 2015, VA Women's Health Services and the VA Women's Health Research Network requested an updated literature review to facilitate policy and research planning. METHODS: The Minneapolis VA Evidence-based Synthesis Program performed a systematic search of research related to female Veterans' health published from 2008 through 2015...
September 14, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28885875/post-traumatic-growth-and-resilience-in-adolescent-and-young-adult-cancer-patients-an-overview
#5
Suzanne R Greup, Suzanne E J Kaal, Rosemarie Jansen, Eveliene Manten-Horst, Melissa S Y Thong, Winette T A van der Graaf, Judith B Prins, Olga Husson
The aim of this study was to provide an overview of the literature on post-traumatic growth (PTG) and resilience among adolescent and young adult (AYA) cancer patients. A literature search in Embase, PsychInfo, PubMed, Web of Science, Cochrane Library, and Cinahl was carried out. Thirteen articles met the pre-defined inclusion criteria. Qualitative interview studies showed that AYA cancer patients report PTG and resilience: PTG is described by AYA cancer patients in terms of benefit finding, including changing view of life and feeling stronger and more confident, whereas resilience is described as a balance of several factors, including stress and coping, goals, optimism, finding meaning, connection, and belonging...
September 8, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28885623/chronic-endocrine-consequences-of-traumatic-brain-injury-what-is-the-evidence
#6
REVIEW
Marianne Klose, Ulla Feldt-Rasmussen
Traumatic brain injury (TBI) is a major public health problem with potentially debilitating consequences for the individual. Hypopituitarism after TBI has received increasing attention over the past decade; development of the condition as a consequence of TBI was previously hardly mentioned in textbooks on the subject. Hypopituitarism has been reported in more than 25% of patients with TBI and is now thought to be one of the most important causes of treatable morbidity in TBI survivors. However, most clinicians dealing with neuroendocrine diseases and TBI generally do not see such a high incidence of hypopituitarism...
September 8, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28884713/-mental-disorders-in-patients-with-breast-cancer-a-differentiated-approach-to-the-study-of-nozogeny
#7
O V Shushpanova
AIM: To study mental disorders in patients with breast cancer (BC) at different stages of the disease taking into account premorbid characteristics and psychosomatic correlations in their development. MATERIAL AND METHODS: The study included 82 patients with histologically confirmed BC. The first group consisted of 30 patients (mean age 49.7±11.1 years) with the first established diagnosis of BC and mental disorders caused by somatic disease (ICD-10 F40-F48, stress-related neurotic and somatoform disorders)...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28882361/relation-between-parental-psychopathology-and-posttraumatic-growth-after-a-child-s-admission-to-intensive-care-two-faces-of-the-same-coin
#8
Rocío Rodríguez-Rey, Jesús Alonso-Tapia
OBJECTIVES: Confronted with the potentially traumatic experience of a child's admission to a paediatric intensive care unit, parents may experience psychopathological post-trauma symptoms as well as posttraumatic growth. The aim of this cross-sectional study was to explore the relation between psychopathology symptoms, namely, posttraumatic stress disorder), anxiety and depression, as well as post traumatic growth in parents following their child's hospitalisation in a paediatric intensive care unit...
September 4, 2017: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/28882068/self-esteem-and-hope-mediate-the-relations-between-social-support-and-post-traumatic-stress-disorder-and-growth-in-adolescents-following-the-ya-an-earthquake
#9
Xiao Zhou, Xinchun Wu, Rui Zhen
BACKGROUND AND OBJECTIVE: Although posttraumatic stress disorders (PTSD) and posttraumatic growth (PTG) can co-exist, and several theories suggest that social support, self-esteem, and hope can predict both PTSD and PTG, no study to date has examined the combined role of social support, self-esteem, and hope in PTSD and PTG. The present study aimed to simultaneously examine the mediating roles of self-esteem and hope in the relations between social support and PTSD, and between social support and PTG...
September 7, 2017: Anxiety, Stress, and Coping
https://www.readbyqxmd.com/read/28878700/growth-mixture-modeling-of-depression-symptoms-following-traumatic-brain-injury
#10
Rapson Gomez, Clive Skilbeck, Matt Thomas, Mark Slatyer
Growth Mixture Modeling (GMM) was used to investigate the longitudinal trajectory of groups (classes) of depression symptoms, and how these groups were predicted by the covariates of age, sex, severity, and length of hospitalization following Traumatic Brain Injury (TBI) in a group of 1074 individuals (696 males, and 378 females) from the Royal Hobart Hospital, who sustained a TBI. The study began in late December 2003 and recruitment continued until early 2007. Ages ranged from 14 to 90 years, with a mean of 35...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28872936/quantitative-and-qualitative-evaluations-of-the-enhanced-logo-autobiography-program-for-korean-american-women
#11
Kyung Mi Sung, Kunsook Bernstein
This study extends Bernstein et al.'s (2016) investigation of the effects of the Enhanced Logo-autobiography Program on Korean-American women's depressive symptoms, coping strategies, purpose in life, and posttraumatic growth by analyzing quantitative and qualitative data. This study's participants significantly improved on quantitative measures of depression, coping strategies, purpose in life, and post-traumatic growth at eight weeks post-intervention and follow-up. The qualitative content analysis revealed 17 themes with five essential themes...
September 5, 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28863129/insulin-like-growth-factor-type-1-and-its-relation-with-neuropsychiatric-disorders
#12
REVIEW
Jonathan Adrián Zegarra-Valdivia
The study of different neurotrophic factors, including insulin-like growth factor-1 (IGF-1), has become relevant in recent years because of its role in brain activity and its potential therapeutic applications. This article reviews IGF-1 in relation to neuropsychiatric disorders such as autism, anxiety, depression, post-traumatic stress disorder and Alzheimer's disease. An exhaustive search of different original articles, clinical, experimental, and review studies was carried out in MEDLINE/PubMed and ScienceDirect databases, selecting 80 high-impact post-2000 publications...
August 28, 2017: Medwave
https://www.readbyqxmd.com/read/28852886/relationships-between-illness-perception-and-post-traumatic-growth-among-newly-diagnosed-hiv-positive-men-who-have-sex-with-men-in-china
#13
Joseph T F Lau, Xiaobing Wu, Anise M S Wu, Zixin Wang, Phoenix K H Mo
Newly diagnosed HIV-positive men who have sex with men (NHMSM) are at high risk of mental health problems but may also develop post-traumatic growth (PTG). According to the Common Sense Model, illness perception (including both cognitive representation and emotional representation) affects coping and health-related outcomes. A cross-sectional survey was conducted to examine the associations between illness perception and PTG among 225 NHMSM in Chengdu, China. Linear regression analyses indicated that the constructs of emotional representation subscale (β = -0...
August 29, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28852446/effect-of-chondroitinase-abc-on-inflammatory-and-oxidative-response-following-spinal-cord-injury
#14
Mahboobe Akbari, Mohammad Khaksari, Maryam Rezaeezadeh-Roukerd, Moghaddameh Mirzaee, Mahdieh Nazari-Robati
OBJECTIVES: Chondroitinase ABC (cABC) treatment improves functional recovery following spinal cord injury (SCI) through degrading inhibitory molecules to axon growth. However, cABC involvement in other pathological processes contributing to SCI remains to be investigated. Here, we studied the effect of cABC I on oxidative stress and inflammation developed in a rat model of SCI. MATERIALS AND METHODS: Male rats (220-250 g) were divided into three groups (n=28) including rats that underwent SCI (SCI group), rats subjected to SCI and received an intrathecal injection of phosphate buffer saline (SCI+PBS group), and rats that underwent SCI and received cABC intrathecally (SCI+E group)...
July 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28834244/striking-a-new-path-in-reducing-cartilage-breakdown-combination-of-antioxidative-therapy-and-chondroanabolic-stimulation-after-blunt-cartilage-trauma
#15
Jana Riegger, Helga Joos, Hans-Georg Palm, Benedikt Friemert, Heiko Reichel, Anita Ignatius, Rolf E Brenner
Cartilage injury can trigger crucial pathomechanisms, including excessive cell death and expression of matrix-destructive enzymes, which contribute to the progression of a post-traumatic osteoarthritis (PTOA). With the intent to create a novel treatment strategy for alleviating trauma-induced cartilage damage, we complemented a promising antioxidative approach based on cell and chondroprotective N-acetyl cysteine (NAC) by chondroanabolic stimulation. Overall, three potential pro-anabolic growth factors - IGF-1, BMP7 and FGF18 - were tested comparatively with and without NAC in an ex vivo human cartilage trauma-model...
August 22, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28810998/delayed-diagnosis-of-acromegaly-in-the-context-of-post-traumatic-stress-disorder-due-to-symptoms-mimicking-known-psychotropic-medication-side-effects
#16
Ray-Bernard Portier, Afshin Afarin, Sara Pope
BACKGROUND: Acromegaly is caused by elevated secretion of human growth hormone, which is frequently because of intracranial tumors. This diagnosis is fairly uncommon with an incidence of 3 to 4 cases per million patients per year. We are presenting a case of acromegaly diagnosed in an active duty Chief Petty Officer. MATERIALS AND METHODS: A 38-year-old male Chief Petty Officer with no previous mental health diagnosis experienced post-traumatic stress disorder (PTSD)-like symptoms in early 2012 after deploying to Iraq and Afghanistan from 2010 to 2011...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28799784/memory-as-a-cognitive-representation-of-post-traumatic-growth
#17
Shuhui Huang, Yiqun Gan
BACKGROUND AND OBJECTIVES: Previous studies on traumatic memory have primarily focused on the correlation between traumatic symptoms and negative memories, often utilizing the directed forgetting paradigm. Different from previous research, this study aimed to examine the correlation of post-traumatic growth (PTG) and positive memories, with the objective to explore the directed forgetting effect of positive material and its relationship with PTG. DESIGN: A 2 (PTG level: high vs...
August 11, 2017: Anxiety, Stress, and Coping
https://www.readbyqxmd.com/read/28797177/predictors-of-post-traumatic-growth-in-stroke-survivors
#18
Grace Kelly, Reg Morris, Hamsaraj Shetty
PURPOSE: The development of post-traumatic growth was studied longitudinally within 14 months poststroke. The predictions of two models of post-traumatic growth were examined. METHOD: Forty-three stroke survivors were investigated at two time points (i.e., time 1 and time 2), six months apart. Each completed the Post-traumatic Growth Inventory, Rumination Scale, Impact of Events Scale, Multidimensional Scale of Social Support, the Barthel Index and the COPE scale...
August 10, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28771096/trajectories-of-cannabis-use-beginning-in-adolescence-associated-with-symptoms-of-posttraumatic-stress-disorder-in-the-mid-thirties
#19
Jung Yeon Lee, Judith S Brook, Stephen J Finch, David W Brook
BACKGROUND: Posttraumatic stress disorder (PTSD) symptoms are related to a number of adverse consequences such as substance use and general medical conditions. The present longitudinal study seeks to find the longitudinal patterns of cannabis use as precursors of PTSD symptoms. Such information will serve as a guide for intervention programs for PTSD. METHODS: Growth mixture modeling was conducted to identify the cannabis use trajectory groups using a community sample of 674 participants (53% African Americans, 47% Hispanics of Puerto Rican decent; 60% females) from the Harlem Longitudinal Development Study...
August 3, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28736137/nogo-presence-is-inversely-associated-with-shifts-in-cortical-microglial-morphology-following-experimental-diffuse-brain-injury
#20
Jenna M Ziebell, Helen Ray-Jones, Jonathan Lifshitz
Diffuse traumatic brain injury (TBI) initiates secondary pathology, including inflammation and reduced myelination. Considering these injury-related pathologies, the many states of activated microglia as demonstrated by differing morphologies would form, migrate, and function in and through fields of growth-inhibitory myelin byproduct, specifically Nogo. Here we evaluate the relationship between inflammation and reduced myelin antigenicity in the wake of diffuse TBI and present the hypothesis that the Nogo-66 receptor antagonist peptide NEP(1-40) would reverse the injury-induced shift in distribution of microglia morphologies by limiting myelin-based inhibition...
September 17, 2017: Neuroscience
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