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https://www.readbyqxmd.com/read/28735486/detection-and-quantification-of-acute-myeloid-leukemia-associated-fusion-transcripts
#1
Jonathan Schumacher, Philippe Szankasi, Todd W Kelley
Real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR)-based detection of abnormal fusion transcripts is an important strategy for the diagnosis and monitoring of patients with acute myeloid leukemia (AML) with t(8;21)(q22;q22); RUNX1-RUNX1T1, inv(16)(p13.1;q22); CBFB-MYH11 or t(15;17)(q22;q12); PML-RARA. In RT-qPCR assays, patient-derived cDNA is subjected to amplification using PCR primers directed against the fusion transcript of interest as well as a reference gene for normalization...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28735379/multidisciplinary-management-of-clival-chordomas-long-term-clinical-outcome-in-a-single-institution-consecutive-series
#2
Petter Förander, Jiri Bartek, Michael Fagerlund, Hamza Benmaklouf, Ernest Dodoo, Alia Shamikh, Pär Stjärne, Tiit Mathiesen
OBJECTIVE: Chordomas of the skull base have high recurrence rates even after radical resection and adjuvant radiotherapy. We evaluate the long-term clinical outcome using multidisciplinary management in the treatment of clival chordomas. METHODS: Between 1984 and 2015, 22 patients diagnosed with an intracranial chordoma were treated at the Karolinska University Hospital, Stockholm, Sweden. Sixteen of 22 were treated with Gamma Knife radiosurgery (GKRS) for tumour residual or progression during the disease course...
July 22, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28735178/development-of-a-real-time-prediction-model-of-driver-behavior-at-intersections-using-kinematic-time-series-data
#3
Yaoyuan V Tan, Michael R Elliott, Carol A C Flannagan
As connected autonomous vehicles (CAVs) enter the fleet, there will be a long period when these vehicles will have to interact with human drivers. One of the challenges for CAVs is that human drivers do not communicate their decisions well. Fortunately, the kinematic behavior of a human-driven vehicle may be a good predictor of driver intent within a short time frame. We analyzed the kinematic time series data (e.g., speed) for a set of drivers making left turns at intersections to predict whether the driver would stop before executing the turn...
July 20, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28735017/en-bloc-thulium-laser-enucleation-of-the-prostate-surgical-technique-and-advantages-compared-with-the-classical-technique
#4
G Saredi, A Pacchetti, G M Pirola, L Berti, F Ambrosini, E Martorana, A M Marconi
OBJECTIVE: To report a new technique for Thulium Laser Enucleation of the Prostate, that we called "En-bloc" ThuLEP. METHODS: A full anatomical description of the technique is provided. We assessed operative variables of a 50-patient series, treated with the new "En-bloc" ThuLEP and compared them with another series of 50 patients (that had the same preoperative parameters) operated with the classical "three lobes" technique, to assess the feasibility of the new one...
July 19, 2017: Urology
https://www.readbyqxmd.com/read/28735011/assessment-and-elimination-of-the-effects-of-head-movement-on-meg-resting-state-measures-of-oscillatory-brain-activity
#5
Eirini Messaritaki, Loes Koelewijn, Diana C Dima, Gemma M Williams, Gavin Perry, Krish D Singh
Magnetoencephalography (MEG) is increasingly being used to study brain function because of its excellent temporal resolution and its direct association with brain activity at the neuronal level. One possible cause of error in the analysis of MEG data comes from the fact that participants, even MEG-experienced ones, move their head in the MEG system. Head movement can cause source localization errors during the analysis of MEG data, which can result in the appearance of source variability that does not reflect brain activity...
July 19, 2017: NeuroImage
https://www.readbyqxmd.com/read/28734996/the-design-of-novel-visible-light-driven-ag-cdo-as-smart-nanocomposite-for-photodegradation-of-different-dye-contaminants
#6
K Saravanakumar, V Muthuraj, M Jeyaraj
In this paper, we report a novel visible light driven Ag/CdO photocatalyst, fabricated for the first time via one pot hydrothermal method and further applied for the photodegradation of two important exemplar water contaminants, Malachite green and Acid Orange 7. The microstructure, composition and optical properties of Ag/CdO nanocomposites were thoroughly investigated by various techniques. Scanning electron microscopy clearly shows that Ag NPs were strongly embedded between the CdO nanoparticles. Among the series of synthesized Ag/CdO nanocomposites, (5%) Ag/CdO nanocomposite possesses enhanced photocatalytic activity...
July 17, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28734809/-severe-poisoning-by-traditional-medication-in-the-newborn
#7
A Oulmaati, F Hmami, S Achour, A Bouharrou
The use of traditional products for therapeutic purposes in the newborn cause many cases of severe poisoning, especially in newborns. The aim of this study was to identify the main medicinal plants causing poisoning and emphasize the seriousness of poisonous plants. We report a series of eight newborns admitted for intake of poisonous medicinal plants admitted to the neonatal unit and neonatal intensive care unit at the Fez (Morocco) Hassan II University Hospital in 2014. The reasons for use were dominated by the infant's refusing to suckle...
July 19, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28734679/assessment-of-biodistribution-using-mesenchymal-stromal-cells-algorithm-for-study-design-and-challenges-in-detection-methodologies
#8
Blanca Reyes, Maria Isabel Coca, Margarita Codinach, María Dolores López-Lucas, Anna Del Mazo-Barbara, Marta Caminal, Irene Oliver-Vila, Valentín Cabañas, Silvia Lope-Piedrafita, Joan García-López, José M Moraleda, Cesar G Fontecha, Joaquim Vives
BACKGROUND AIMS: Biodistribution of candidate cell-based therapeutics is a critical safety concern that must be addressed in the preclinical development program. We aimed to design a decision tree based on a series of studies included in actual dossiers approved by competent regulatory authorities, noting that the design, execution and interpretation of pharmacokinetics studies using this type of therapy is not straightforward and presents a challenge for both developers and regulators...
July 19, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28734578/phosphatidylserine-is-the-signal-for-tam-receptors-and-their-ligands
#9
REVIEW
Greg Lemke
Nature repeatedly repurposes, in that molecules that serve as metabolites, energy depots, or polymer subunits are at the same time used to deliver signals within and between cells. The preeminent example of this repurposing is ATP, which functions as a building block for nucleic acids, an energy source for enzymatic reactions, a phosphate donor to regulate intracellular signaling, and a neurotransmitter to control the activity of neurons. A series of recent studies now consolidates the view that phosphatidylserine (PtdSer), a common phospholipid constituent of membrane bilayers, is similarly repurposed for use as a signal between cells and that the ligands and receptors of the Tyro3/Axl/Mer (TAM) family of receptor tyrosine kinases (RTKs) are prominent transducers of this signal...
July 19, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28734500/a-new-online-delay-estimation-based-robust-adaptive-stabilizer-for-multi-input-neutral-systems-with-unknown-actuator-nonlinearities
#10
A H Tahoun
This paper studies the problem of actuator-nonlinearities compensation in the multi-input uncertain neutral systems. The neutral systems with different unknown time-varying delays, unmodeled dynamics, nonlinear perturbations and disturbances are considered. A new methodology based on the online estimation of the delays to compensate for the effects generated by dead-zone and saturation, acting in series on a system's input are presented. The online estimations of the unknown delays are accomplished by adaptive laws that guarantee the exponential stabilities of the estimated delays...
July 19, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28734494/bone-transport-versus-acute-shortening-for-the-management-of-infected-tibial-non-unions-with-bone-defects
#11
Kevin Tetsworth, Cengiz Sen, John E Herzenberg, Matthew Jaffe, Dean C Maar, Vaida Glatt, Dror Paley, Erik Hohmann
INTRODUCTION: This study compared bone transport to acute shortening/lengthening in a series of infected tibial segmental defects for infected tibial non-union. METHODS: In a retrospective comparative study 42 patients treated for infected tibial non-union with segmental bone loss measuring between 3 and 10cm were included. Group A was treated with bone transport and Group B with acute shortening/lengthening. All patients were treated by Ilizarov methods for gradual correction as bi-focal or tri-focal treatment; the treating surgeon selected either transport or acute shortening based on clinical considerations...
July 12, 2017: Injury
https://www.readbyqxmd.com/read/28734362/discrimination-of-bacteria-by-rapid-sensing-their-metabolic-volatiles-using-an-aspiration-type-ion-mobility-spectrometer-a-ims-and-gas-chromatography-mass-spectrometry-gc-ms
#12
Ileana Andreea Ratiu, Victor Bocos-Bintintan, Adrian Patrut, Victor Hugo Moll, Matthew Turner, C L Paul Thomas
The objective of our study was to investigate whether one may quickly and reliably discriminate different microorganism strains by direct monitoring of the headspace atmosphere above their cultures. Headspace samples above a series of in vitro bacterial cultures were directly interrogated using an aspiration type ion mobility spectrometer (a-IMS), which produced distinct profiles ("fingerprints") of ion currents generated simultaneously by the detectors present inside the ion mobility cell. Data processing and analysis using principal component analysis showed net differences in the responses produced by volatiles emitted by various bacterial strains...
August 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28734296/spherical-harmonics-analysis-of-surface-density-fluctuations-of-spherical-ionic-sds-and-nonionic-c12e8-micelles-a-molecular-dynamics-study
#13
Noriyuki Yoshii, Yuki Nimura, Kazushi Fujimoto, Susumu Okazaki
The surface structure and its fluctuation of spherical micelles were investigated using a series of density correlation functions newly defined by spherical harmonics and Legendre polynomials based on the molecular dynamics calculations. To investigate the influence of head-group charges on the micelle surface structure, ionic sodium dodecyl sulfate and nonionic octaethyleneglycol monododecylether (C12E8) micelles were investigated as model systems. Large-scale density fluctuations were observed for both micelles in the calculated surface static structure factor...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28734251/climatic-controls-of-ecohydrological-responses-in-the-highlands-of-northern-ethiopia
#14
Samuale Tesfaye, Emiru Birhane, Toon Leijnse, S E A T M van der Zee
Climate variability and recurrent droughts have a strong negative impact on agricultural production and hydrology in the highlands northern Ethiopia. Since the 1980s, numerous mitigation and land rehabilitation measures have been implemented by local and national authorities to reduce these impacts, are often poorly effective. As underlying reason may be that controlling relationships between climate and ecohydrology at medium-sized catchments (10-10,000km(2)) of semi-arid highlands are not well known. We investigated trends and relationships in precipitation, temperature, streamflow, and net primary productivity (NPP)...
July 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28734194/high-yield-one-pot-production-of-18-f-fch-via-a-modified-tracerlab-fxfn-module
#15
Ya-Yao Huang, Chia-Ling Tsai, Hsiang-Ping Wen, Kai-Yuan Tzen, Ruoh-Fen Yen, Chyng-Yann Shiue
INTRODUCTION: [(18)F]Fluoromethylcholine ([(18)F]FCH) is a potent tumors imaging agent. In order to fulfill the demand of pre-clinical and clinical studies, we have developed an automated high yield one-pot synthesis of this potent tumors imaging agent. METHODS: [(18)F]FCH was synthesized using a modified TRACERlab FxFN module. Briefly, dibromomethane (10% in CH3CN) was fluorinated with K[(18)F]/K 2.2.2 in a glassy carbon reaction vessel at 120°C for about 5min to generate [(18)F]fluorobromomethane ([(18)F]FBM)...
July 15, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28733996/long-term-effectiveness-of-the-preoperative-smoking-cessation-programme-at-western-health
#16
Hugh Taylor, Amalia Karahalios, David Bramley
BACKGROUND: Smoking is associated with adverse effects in the perioperative period, including elevated risk of death. The perioperative period provides an opportunity to engage with patients who are smokers to encourage smoking cessation, often referred to as a 'teachable moment'. We developed a smoking intervention model for the pre-admission clinic (PAC) at Western Health, Victoria, Australia. This case series aimed to assess the impact of the smoking intervention model, which is standard of care, on the participant's smoking habits over four time points...
July 21, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28733839/limits-in-feature-based-attention-to-multiple-colors
#17
Taosheng Liu, Michael Jigo
Attention to a feature enhances the sensory representation of that feature. Although much has been learned about the properties of attentional modulation when attending to a single feature, the effectiveness of attending to multiple features is not well understood. We investigated this question in a series of experiments using a color-detection task while varying the number of attended colors in a cueing paradigm. Observers were shown either a single cue, two cues, or no cue (baseline) before detecting a coherent color target...
July 21, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/28733780/robotic-left-lateral-sectionectomy-as-stepwise-approach-for-cirrhotic-liver
#18
Raphael L C Araujo, Luís Antônio de Castro, Fernando E C Fellipe, Diego Burgardt, Durval R Wohnrath
Laparoscopy is considered the gold standard approach to perform left lateral sectionectomy (LLS). Furthermore, laparoscopy for cirrhotic patients can reduce intraoperative bleeding and postoperative morbidity when compared to open surgery. Although robotic surgery is feasible for both minor and major liver resections, it remains a work in progress and only few series reported this approach for cirrhotic patients. We reported two cases of 62-year-old men, both with hepatitis C virus and alcoholic cirrhosis, but with compensated liver functions (MELD 9-10 and Child-Pugh A5-A6)...
July 21, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28733775/how-swallow-pressures-and-dysphagia-affect-malnutrition-and-mealtime-outcomes-in-long-term-care
#19
Ashwini M Namasivayam-MacDonald, Jill M Morrison, Catriona M Steele, Heather Keller
Malnutrition is a major cause of hospitalization for residents of long-term care facilities (LTC). Dysphagia is thought to contribute to malnutrition. Tongue weakness is suggested to predict poor food intake, longer meals, and dysphagia. We explored the relationships between tongue strength, dysphagia, malnutrition and mealtime outcomes in LTC residents. Data were collected from 639 LTC residents (199 male), aged 62-102 (mean 87). Maximum isometric tongue pressures (MIPs) and saliva swallow pressures (MSPs) were measured using the Iowa Oral Performance Instrument...
July 21, 2017: Dysphagia
https://www.readbyqxmd.com/read/28733751/evaluation-of-the-safety-and-efficacy-of-metoprolol-infusion-for-children-and-adolescents-with-hypertensive-crises-a-retrospective-case-series
#20
Rola Saqan, Hanan Thiabat
BACKGROUND: Acute severe hypertension occurs infrequently in pediatric patients and, consequently, data on the efficacy and safety of most antihypertensive agents, as well as the adverse events associated with these agents, are very limited in this population. In this case series, we evaluated the use of metoprolol infusion in children with hypertensive emergencies. METHODS: The study population comprised children younger than 18 years who had been admitted to the pediatric intensive care unit at King Abdullah University Hospital with blood pressure above the 99th percentile for age, height, and sex and who were symptomatic at the time of presentation...
July 21, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
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