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https://www.readbyqxmd.com/read/29684907/efficiency-of-extraction-and-conversion-of-pseudoephedrine-to-methamphetamine-from-tamper-resistant-and-non-tamper-resistant-formulations
#1
Brandon Presley, Bob Bianchi, John Coleman, Fran Diamond, Gerry McNally
Clandestine chemists have demonstrated an ability to convert commercially available pseudoephedrine formulations to methamphetamine. Some of these formulations have properties that manufacturers claim limit or block the extraction of pseudoephedrine and its direct conversion to methamphetamine. In this study, 3 commercially available pseudoephedrine formulations were evaluated for ease of extraction and conversion to methamphetamine using a common chemistry technique called the one-pot method that is frequently employed by clandestine chemists...
April 16, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29684782/evaluation-of-normal-lung-tissue-complication-probability-in-gated-and-conventional-radiotherapy-using-the-4d-xcat-digital-phantom
#2
Sara Shahzadeh, Somayeh Gholami, Seyed Mahmood Reza Aghamiri, Hojjat Mahani, Mansoure Nabavi, Faraz Kalantari
PURPOSE: The present study was conducted to investigate normal lung tissue complication probability in gated and conventional radiotherapy (RT) as a function of diaphragm motion, lesion size, and its location using 4D-XCAT digital phantom in a simulation study. MATERIALS AND METHODS: Different time series of 3D-CT images were generated using the 4D-XCAT digital phantom. The binary data obtained from this phantom were then converted to the digital imaging and communication in medicine (DICOM) format using an in-house MATLAB-based program to be compatible with our treatment planning system (TPS)...
April 12, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29684780/the-influence-of-landscape-s-dynamics-on-the-oriental-migratory-locust-habitat-change-based-on-the-time-series-satellite-data
#3
Yue Shi, Wenjiang Huang, Yingying Dong, Dailiang Peng, Qiong Zheng, Puyun Yang
Landscape structure and vegetation coverage are important habitat conditions for Oriental Migratory Locust infestation in East Asia. Characterizing the landscape's dynamics of locust habitat is meaningful for reducing the occupation of locusts and limiting potential risks. To better understand causes and consequences of landscape pattern and locust habitat, it is not enough to simply detect locust habitat of each year. Rather, landcover transitions causing the change of locust habitat area must also be explored...
April 20, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29684739/evaluating-meteorological-data-from-weather-stations-and-from-satellites-and-global-models-for-a-multi-site-epidemiological-study
#4
Josh M Colston, Tahmeed Ahmed, Cloupas Mahopo, Gagandeep Kang, Margaret Kosek, Francisco de Sousa Junior, Prakash Sunder Shrestha, Erling Svensen, Ali Turab, Benjamin Zaitchik
BACKGROUND: Longitudinal and time series analyses are needed to characterize the associations between hydrometeorological parameters and health outcomes. Earth Observation (EO) climate data products derived from satellites and global model-based reanalysis have the potential to be used as surrogates in situations and locations where weather-station based observations are inadequate or incomplete. However, these products often lack direct evaluation at specific sites of epidemiological interest...
April 20, 2018: Environmental Research
https://www.readbyqxmd.com/read/29684697/new-arene-ruthenium-ii-complexes-of-4%C3%A2-aryl%C3%A2-4h%C3%A2-naphthopyrans-with-anticancer-and-anti-vascular-activities
#5
Florian Schmitt, Jana Kasparkova, Viktor Brabec, Gerrit Begemann, Rainer Schobert, Bernhard Biersack
A series of four 2‑amino‑3‑cyano‑4‑(3/4‑pyridyl)‑4H‑benzo[h]chromenes 2a-d and their dichlorido(p‑cymene)ruthenium(II) complexes 3a-d were tested for antiproliferative, vascular-disruptive, anti-angiogenic and DNA-binding activity. The coordination of the 4‑pyridyl‑4H‑naphthopyrans 2 to ruthenium led to complexes with pleiotropic effects. Unlike the free ligands 2a-d, their ruthenium complexes 3a-d showed a significant affinity for DNA as demonstrated by electrophoretic mobility shift assays (EMSA) and ethidium bromide assays...
April 5, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29684465/an-asymptotic-theory-for-cross-correlation-between-auto-correlated-sequences-and-its-application-on-neuroimaging-data
#6
Yunyi Zhou, Chenyang Tao, Wenlian Lu, Jianfeng Feng
BACKGROUND: Functional connectivity is among the most important tools to study brain. The correlation coefficient, between time series of different brain areas, is the most popular method to quantify functional connectivity. Correlation coefficient in practical use assumes the data to be temporally independent. However, the time series data of brain can manifest significant temporal auto-correlation. NEW METHOD: A widely applicable method is proposed for correcting temporal auto-correlation...
April 20, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29684281/superactivity-of-mof-808-towards-peptide-bond-hydrolysis
#7
Hong Giang T Ly, Guangxia Fu, Aleksandar Kondinski, Bart Bueken, Dirk De Vos, Tatjana N Parac-Vogt
MOF-808, a Zr(IV)-based metal-organic framework, has been proven to be a very effective heterogeneous catalyst for the hydrolysis of the peptide bond in a wide range of peptides and in hen egg white lysozyme protein. The kinetic experiments with a series of Gly-X dipeptides with varying nature of amino acid side chain have shown that MOF-808 exhibits selectivity depending on the size and chemical nature of the X side chain. Dipeptides with smaller or hydrophilic residues were hydrolyzed faster than those with bulky and hydrophobic residues that lack electron rich functionalities which could engage in favourable intermolecular interactions with the btc linkers...
April 23, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29684033/time-series-smoother-for-effect-detection
#8
Cheng You, Dennis K J Lin, S Stanley Young
In environmental epidemiology, it is often encountered that multiple time series data with a long-term trend, including seasonality, cannot be fully adjusted by the observed covariates. The long-term trend is difficult to separate from abnormal short-term signals of interest. This paper addresses how to estimate the long-term trend in order to recover short-term signals. Our case study demonstrates that the current spline smoothing methods can result in significant positive and negative cross-correlations from the same dataset, depending on how the smoothing parameters are chosen...
2018: PloS One
https://www.readbyqxmd.com/read/29683953/outcomes-of-proton-beam-radiation-therapy-for-retinoblastoma-with-vitreous-seeds
#9
Eun Hye Jung, Jeong Hun Kim, Joo Young Kim, Dong Hyun Jo, Young Suk Yu
Vitreous seeds are the most challenging aspect in the management of retinoblastoma. We report the outcomes of treatment with proton beam radiation therapy (PBRT) for retinoblastoma with vitreous seeds in naive or previously treated eyes. In this retrospective case series, we analyzed data of 4 retinoblastoma patients with vitreous seeds who received PBRT at the Proton Therapy Center, National Cancer Center in Korea between June 2007 and August 2017. All 4 eyes treated by PBRT were classified as group D according to the International Classification of Retinoblastoma (ICRB) criteria, and the vitreous seeds, as class 3 (clouds)...
April 20, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29683857/management-of-tibial-bow-in-fibular-deficiency
#10
David E Westberry, Ashley M Carpenter, John Barrera, Alison Westberry
BACKGROUND: Deformity of the tibia, including shortening and angulation, may accompany severe forms of postaxial hypoplasia (fibular deficiency). The current literature reflects varying opinions on the appropriate management for tibial deformity in the setting of fibular deficiency. METHODS: We performed a retrospective review to determine outcomes of tibial deformity correction in patients with a primary diagnosis of fibular deficiency. Clinical and radiographic outcomes of patients treated with foot ablation were reviewed to establish indications for tibial deformity correction, identify occurrence of additional surgical procedures related to limb alignment or deformity, and characterize difficulties with prosthetic wear potentially related to residual or recurrent tibial deformity...
April 20, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29683731/bronchiolitis-obliterans-murine-model-induced-by-nitric-acid-aerosol-inhalation-an-economical-and-reproducible-model
#11
Jianing Yin, Xiaobo Ma, Fei Huang, Yucong Ma, Yanan Li
PURPOSE: Bronchiolitis obliterans (BO) is a highly debilitative and fatal syndrome associated with a series of severe lower airway disorders. The pathogenesis of BO is complicated and not entirely understood. An appropriate animal model of BO may aid research into its pathogenesis. Here, we establish a mouse model of BO to provide insight into this disease. MATERIALS AND METHODS: 6-8 week old BABL/c mice were exposed to 5% nitric acid (NA) aerosol through a nebulizer for 3 hours, and controls were exposed to distilled water instead...
April 23, 2018: Experimental Lung Research
https://www.readbyqxmd.com/read/29683655/alkaline-phosphatase-assay-based-on-the-chromogenic-interaction-of-diethanolamine-with-4-aminophenol
#12
Jian Sun, Jiahui Zhao, Xingfu Bao, Qifeng Wang, Xiurong Yang
Diethanolamine (DEA) has been extensively utilized as an alkaline buffer in current assays of alkaline phosphatase (ALP) activity in the past decades. While playing the role of a buffer, DEA has been widely ignored about its chemical reactivity in such assays. Herein, we report an interesting chromogenic interaction between DEA and 4-aminophenol (AP) in the presence of H2 O for the first time, which inspires us to develop a novel DEA-participated ALP activity assay by using 4-aminophenyl phos-phate (APP) as a substrate...
April 23, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29683410/the-effect-of-dry-needling-on-spasticity-gait-and-muscle-architecture-in-patients-with-chronic-stroke-a-case-series-study
#13
Sarafraz Hadi, Otadi Khadijeh, Mohammadreza Hadian, Ayoobi Yazdi Niloofar, Gholamreza Olyaei, Bagheri Hossein, Sandra Calvo, Pablo Herrero
Objectives The objective of this study was to assess the short-term effects of dry needling on spasticity, gait, and muscle architecture of patients with chronic stroke. Methods A case series study was designed; and six chronic stroke patients with ankle spasticity and gait impairment received a single session of dry needling for gastrocnemius medialis, lateralis, and soleus muscles. The main outcome measures were the Modified Modified Ashworth Scale (MMAS), and Timed Up and Go test (TUG). In addition, ultrasonography measurements (e...
April 23, 2018: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29683361/human-recombinant-epidermal-growth-factor-in-skin-lesions-77-cases-in-epitelizando-project
#14
Jordi Esquirol-Caussa, Elisabeth Herrero-Vila
OBJECTIVE: To analyze compounded recombinant human Epidermal Growth Factor (rhEGF) effectiveness on skin lesions through a case series. DESIGN: Multicentric series of skin lesions treated with topical recombinant human Epidermal Growth Factor. SITE: Patients from 56 different health professionals, three different countries, two recruitment years. PARTICIPANTS: 77 patients with skin lesions, mean age 63.15 years (min = 18, max = 95); 53...
April 23, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29683163/the-effect-of-solvent-relaxation-time-constants-on-free-energy-gap-law-for-ultrafast-charge-recombination-following-photoinduced-charge-separation
#15
Valentina A Mikhailova, Roman E Malykhin, Anatoly I Ivanov
To elucidate the regularities inherent in the kinetics of ultrafast charge recombination following photoinduced charge separation in donor-acceptor dyads in solutions, the simulations of the kinetics have been performed within the stochastic multichannel point-transition model. Increasing the solvent relaxation time scales has been shown to strongly vary the dependence of the charge recombination rate constant on the free energy gap. In slow relaxing solvents the non-equilibrium charge recombination occurring in parallel with solvent relaxation is very effective so that the charge recombination terminates at the non-equilibrium stage...
April 23, 2018: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29682694/the-american-society-of-hematology-ash-medical-educators-institute-a-pilot-faculty-development-project-for-hematology-educators
#16
Jennifer C Kesselheim, Charles P Clayton, Josel Fritz, Roy E Smith, Scott D Gitlin, Erin Reid, Kenneth S Zuckerman, Marc J Kahn
Clinician educators at academic medical centers often lack the community, mentorship, and faculty development to support their missions around education scholarship and teaching. Inadequate support for clinician educators can lead to professional dissatisfaction and slowed academic advancement. In 2014, ASH conducted a needs assessment of medical school hematology course directors, hematology-oncology fellowship program directors, and other ASH members identified as educators to determine this community's desire for faculty development in medical education...
April 22, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29682335/dielectrophoresis-testing-of-nonlinear-viscoelastic-behaviors-of-human-red-blood-cells
#17
Yuhao Qiang, Jia Liu, E Du
Dielectrophoresis in microfluidics provides a useful tool to test biomechanics of living cells, regardless of surface charges on cell membranes. We have designed an experimental method to characterize the nonlinear viscoelastic behaviors of single cells using dielectrophoresis in a microfluidic channel. This method uses radio frequency, low voltage excitations through interdigitated microelectrodes, allowing probing multiple cells simultaneously with controllable load levels. Dielectrophoretic force was calibrated using a triaxial ellipsoid model...
2018: Micromachines
https://www.readbyqxmd.com/read/29682144/periodic-and-simultaneous-quantification-of-blood-viscosity-and-red-blood-cell-aggregation-using-a-microfluidic-platform-under-in-vitro-closed-loop-circulation
#18
Yang Jun Kang
To evaluate variations of blood circulating in closed loops, hemorheological properties including blood viscosity and red blood cells (RBCs) are quantitatively measured with independent in-vitro instruments after collecting blood from a closed loop. But, most previous methods require periodic blood collections which induce several problems such as geometric differences between the fluidic channel and the in-vitro method, hemodilution, storage time, and unspecific blood flow rates. To resolve these issues, in this study, blood viscosity and RBC aggregation of blood circulating within a closed loop are measured with a microfluidic platform periodically and simultaneously...
March 2018: Biomicrofluidics
https://www.readbyqxmd.com/read/29682031/solitary-fibrous-tumors-of-the-orbit-and-central-nervous-system-a-case-series-analysis
#19
Marisa Brum, Hipólito Nzwalo, Edson Oliveira, Maria Rita Pelejão, Pedro Pereira, João Paulo Farias, José Pimentel
Introduction: Solitary fibrous tumor (SFT) is rarely diagnosed in clinical practice. Since its initial descriptions in the central nervous system (CNS) and the orbits, very few case reports and small case series have expanded their clinical and pathological characterization. We sought to describe a cases series of SFT from a single laboratory of neuropathology belonging to a tertiary university hospital. Methods: Retrospective clinical and histopathological description of eight cases of CNS and orbital SFT diagnosed over a 21-year period of time...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29681805/characterization-of-sensory-motor-behavior-under-cognitive-load-using-a-new-statistical-platform-for-studies-of-embodied-cognition
#20
Jihye Ryu, Elizabeth B Torres
The field of enacted/embodied cognition has emerged as a contemporary attempt to connect the mind and body in the study of cognition. However, there has been a paucity of methods that enable a multi-layered approach tapping into different levels of functionality within the nervous systems (e.g., continuously capturing in tandem multi-modal biophysical signals in naturalistic settings). The present study introduces a new theoretical and statistical framework to characterize the influences of cognitive demands on biophysical rhythmic signals harnessed from deliberate, spontaneous and autonomic activities...
2018: Frontiers in Human Neuroscience
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