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https://www.readbyqxmd.com/read/29454126/iatrogenic-spondylolisthesis-following-open-lumbar-laminectomy-case-series-and-review-of-the-literature
#1
Seba Ramhmdani, Yuanxuan Xia, Risheng Xu, Thomas Kosztowski, Daniel Sciubba, Timothy Witham, Ali Bydon
OBJECTIVE: The diagnosis and surgical management of post-laminectomy spondylolisthesis in patients without pre-operative instability is presented with a review of relevant literature. METHODS: We reviewed the medical records and radiographic studies of 105 patients who underwent first-time bilateral 1-4 level open laminectomies for degenerative lumbar disease at a single academic institution. Patients who initially presented with listhesis and had additional discectomy or fusion procedures were excluded...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29454125/management-of-skull-base-tumors-in-the-obstetric-population-a-case-series
#2
Blake H Priddy, Bradley A Otto, Ricardo L Carrau, Daniel M Prevedello
BACKGROUND: Neoplasms rarely present during pregnancy. However, increase in plasma volume, hormone release induced growth, and tumor hypervascularity, can cause rapid symptoms. These range from not requiring intervention to necessitating emergent operations. OBJECTIVE: We describe an algorithm for the management of symptomatic neoplasm in the obstetric population, and provide recommendations regarding surgical indications and timing. METHODS: Patients who presented to a skull base clinic from 2010-2016 at large tertiary care hospital were reviewed to identify patients who presented with a skull base tumor during pregnancy...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29454104/functional-brain-connectivity-is-predictable-from-anatomic-network-s-laplacian-eigen-structure
#3
Farras Abdelnour, Michael Dayan, Orrin Devinsky, Thomas Thesen, Ashish Raj
How structural connectivity (SC) gives rise to functional connectivity (FC) is not fully understood. Here we mathematically derive a simple relationship between SC measured from diffusion tensor imaging, and FC from resting state fMRI. We establish that SC and FC are related via (structural) Laplacian spectra, whereby FC and SC share eigenvectors and their eigenvalues are exponentially related. This gives, for the first time, a simple and analytical relationship between the graph spectra of structural and functional networks...
February 14, 2018: NeuroImage
https://www.readbyqxmd.com/read/29453957/automatic-detection-of-the-duration-of-visual-static-and-dynamic-stimuli
#4
Szonya Durant, István Sulykos, István Czigler
The perception of the passing of time is fundamental to conscious experience. The duration of a sensory stimulus is one of its defining attributes, but it is not clear how this is encoded in the brain. This work explores whether the duration of a visual stimulus is an attribute that the brain can automatically adapt to and use to predict future stimulus durations. Visual mismatch negativity (vMMN) is an ERP component elicited, even when the stimuli are unattended, when an 'unexpected' visual stimulus appears amongst a series of expected stimuli in an 'oddball' paradigm...
February 14, 2018: Brain Research
https://www.readbyqxmd.com/read/29453777/intramuscular-allopregnanolone-and-ganaxolone-in-a-mouse-model-of-treatment-resistant-status-epilepticus
#5
Dorota Zolkowska, Chun-Yi Wu, Michael A Rogawski
Allopregnanolone (5α-pregnan-3α-ol-20-one) and its synthetic 3β-methyl analog, ganaxolone, are positive allosteric modulators of synaptic and extrasynaptic γ-aminobutyric acid (GABA) A receptors that exhibit antiseizure activity in diverse animal seizure models, including models of status epilepticus (SE). The 2 neuroactive steroids are being investigated as treatments for SE, including as a treatment for SE induced by chemical threat agents. Intramuscular injection is the preferred route of administration in the prehospital treatment of SE...
February 17, 2018: Epilepsia
https://www.readbyqxmd.com/read/29453758/theoretical-study-on-the-optical-response-behavior-to-hydrogen-chloride-gas-of-a-series-of-schiff-base-based-star-shaped-structures
#6
Fei Wang, Tianhong Qi, Zhongmin Su, Yuzhong Xie
Schiff-base compounds have many applications in the field of optoelectronic materials and chemical sensing because of their appealing coordination ability, and simple and easily accessible use in structural modification. Herein, five kinds of star-shaped Schiff-base compounds were designed and their optical response behavior to hydrogen chloride (HCl) gas was studied using dependent/time-dependent density functional theory (DFT/TDDFT). Moreover, the relationship between structures and properties was investigated upon changing the benzene group into N atom or triazine group at the core-position and introducing a methoxyl (-OCH 3 ) or nitro (-NO 2 ) group into the star-shaped Schiff-bases at the tail of the branches...
February 17, 2018: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29453660/verification-of-candidate-microrna-markers-for-parathyroid-carcinoma
#7
Ya Hu, Xiang Zhang, Ming Cui, Zhe Su, Mengyi Wang, Quan Liao, Yupei Zhao
PURPOSE: Parathyroid carcinoma (PCa) is a rare endocrine malignancy with poor prognosis and is often difficult to accurately diagnose both before and after surgery. Dysregulated microRNA (miRNA) levels have been identified in PCa using a limited number of samples. The aim of the present study was to verify a group of miRNA markers in a new series of samples to explore their potential significance in PCa diagnosis. METHODS: A total of 58 tissue samples, including 17 PCa lesions and 41 sporadic parathyroid adenomas (PAds), were obtained from 56 primary hyperparathyroidism (pHPT) patients...
February 16, 2018: Endocrine
https://www.readbyqxmd.com/read/29453658/high-intensity-focused-ultrasound-hifu-therapy-for-benign-thyroid-nodules-without-anesthesia-or-sedation
#8
Pierpaolo Trimboli, Fabiano Bini, Franco Marinozzi, Jung Hwan Baek, Luca Giovanella
BACKGROUND: Thermal ablation of thyroid nodules has gained momentum due to the possibility to avoid surgery. High-intensity focused ultrasound (HIFU) allows thermal treatment by energy ultrasound beam inside the targeted zone. Aim of our study was to evaluate the effects of HIFU treatment using Beamotion mode without anesthesia. METHODS: Since 2016, patients with normal thyroid function, benign thyroid nodules with diameter no larger than 4 cm, and presenting local discomfort and/or compressive symptoms were treated by HIFU...
February 16, 2018: Endocrine
https://www.readbyqxmd.com/read/29453652/significance-of-the-nonneoplastic-renal-parenchymal-findings-in-robotic-partial-nephrectomy-series
#9
Ercan Malkoç, Matthew J Maurice, Oktay Akça, Önder Kara, Homayoun Zargar, Hiury Andrade, Daniel Ramirez, Peter Caputo, Robert Stein, Demirjian Sevag, Jihad H Kaouk
AIM: To describe the pathological characteristics of the peritumoral non-neoplastic renal parenchyma (NNRP) and to investigate their impact on long-term renal function after partial nephrectomy. MATERIALS AND METHODS: In our institutional robotic partial nephrectomy database, we identified 394 cases with pathological assessment of the NNRP and long-term postoperative renal functional follow-up. The NNRP was classified as normal (healthy renal parenchyma) or abnormal, based on the presence of arteriosclerosis, glomerulosclerosis, interstitial fibrosis, interstitial inflammation, and/or tubulopapillary hyperplasia...
February 16, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29453638/effects-of-cpap-therapy-on-cognitive-and-psychomotor-performances-in-patients-with-severe-obstructive-sleep-apnea-a-prospective-1-year-study
#10
Renata Pecotic, Ivana Pavlinac Dodig, Maja Valic, Tea Galic, Linda Lusic Kalcina, Natalija Ivkovic, Zoran Dogas
STUDY OBJECTIVES: We prospectively investigated the effects of continuous positive airway pressure (CPAP) on long-term cognitive and psychomotor performances, and excessive daytime sleepiness in severe obstructive sleep apnea (OSA) patients. METHODS: A total of 40 patients were recruited and 23 patients with severe OSA fully completed the study protocol to investigate the effects of CPAP therapy on psychomotor performance at 1, 3, and 6 months and 1 year following initiation of the therapy...
February 16, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29453596/effectiveness-of-the-sesquiterpene-%C3%AE-bisabolol-in-dogs-with-naturally-acquired-canine-leishmaniosis-an-exploratory-clinical-trial
#11
V Corpas-López, G Merino-Espinosa, C Acedo-Sánchez, V Díaz-Sáez, M C Navarro-Moll, F Morillas-Márquez, J Martín-Sánchez
The use of natural products is a promising approach for treating visceral leishmaniosis. (-)-α-Bisabolol is a sesquiterpene that have been proved active in vivo on Leishmania infantum-infected mice without showing toxicity. A single-centre, parallel-group, randomized, exploratory study was designed to assess its efficacy in a canine leishmaniosis model involving naturally infected dogs. In this clinical trial, 12 dogs were allocated into two groups and were treated with either meglumine antimoniate (100 mg/kg) through subcutaneous route or (-)-α-bisabolol (30 mg/kg) through oral route for two treatment series of 30 days, separated by a 30-day interval...
February 16, 2018: Veterinary Research Communications
https://www.readbyqxmd.com/read/29453488/no-evidence-for-combining-cartilage-treatment-and-knee-osteotomy-in-osteoarthritic-joints-a-systematic-literature-review
#12
REVIEW
G Filardo, S Zaffagnini, R De Filippis, F Perdisa, L Andriolo, C Candrian
PURPOSE: To assess whether the combination of HTO and cartilage treatment produced an additional clinical benefit compared to HTO alone. The secondary aim was to identify if there was any difference among different cartilage procedures in terms of healing potential and clinical outcome. METHODS: A systematic review of the literature was performed on PubMed database by three independent observers according to the following inclusion criteria: clinical reports of any level of evidence, written in the English language, with no time limitation, about HTO associated with cartilage surgical and injective treatment, including surveys reporting clinical, radiological, or second-look outcomes at any follow-up time...
February 16, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29453076/development-of-novel-synthesized-phthalazinone-based-parp-1-inhibitors-with-apoptosis-inducing-mechanism-in-lung-cancer
#13
Hadia Almahli, Elie Hadchity, Maiy Y Jaballah, Racha Daher, Hazem A Ghabbour, Maha M Kabil, Nasser S Al-Shakliah, Wagdy M Eldehna
Herein we report the synthesis of two series of 4-phenylphthalazin-1-ones 11a-i and 4- benzylphthalazin-1-ones 16a-h as anti-lung adenocarcinoma agents with potential inhibitory activity against PARP-1. All the newly synthesized phthalazinones were evaluated for their anti-proliferative activity against A549 lung carcinoma cell line. Phthalazinones 11c-i and 16b, c showed significant cytotoxic activity against A549 cells at different concentrations (0.1, 1 and 10 μM) for two time intervals (24 h and 48 h)...
February 7, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29452968/analysis-and-description-of-disease-specific-quality-of-life-in-patients-with-anal-fistula
#14
Manuel Ferrer-Márquez, Natalia Espínola-Cortés, Ángel Reina-Duarte, José Granero-Molina, Cayetano Fernández-Sola, José Manuel Hernández-Padilla
INTRODUCTION: In patients diagnosed with anal fistula, knowing the quality of life specifically related to the disease can help coloproctology specialists to choose the most appropriate therapeutic strategy for each case. The aim of our study is to analyzse and describe the factors related to the specific quality of life in a consecutive series of patients diagnosed with anal fistula. METHODS: Observational, cross-sectional study carried out from March 2015 to February 2017...
February 13, 2018: Cirugía Española
https://www.readbyqxmd.com/read/29452857/impact-of-the-off-clamp-endoscopic-robot-assisted-simple-enucleation-erase-of-clinical-t1-renal-tumors-on-the-postoperative-renal-function-results-from-a-matched-pair-comparison
#15
Andrea Mari, Simone Morselli, Francesco Sessa, Riccardo Campi, Fabrizio Di Maida, Isabella Greco, Giampaolo Siena, Agostino Tuccio, Gianni Vittori, Sergio Serni, Marco Carini, Andrea Minervini
PURPOSE: To evaluate the surgical and functional outcomes of a matched-paired series of on-clamp vs off-clamp endoscopic robot-assisted simple enucleation (ERASE) and standardized renorraphy in a tertiary referral institution, to search for predictors of functional drop after surgery and to investigate the influence of off-clamp technique in patients presenting these characteristics. MATERIALS AND METHODS: A matched-pair comparison of 120 on-clamp vs 120 off-clamp over 491 patients treated with ERASE was performed...
February 13, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29452629/continuous-betadine-bacitracin-irrigation-for-vascular-graft-infections-a-case-series
#16
David V Strider, Catherine R Ratliff, Kenneth J Cherry, Gilbert R Upchurch
The aim of the study was to conduct a retrospective chart review of patients who underwent betadine/bacitracin continuous irrigation (BBCI) for vascular graft infections (VGIs) to review its use as a treatment option. A retrospective chart review from 2013 to 2017 was conducted of patients with VGIs that were treated with BBCI postremoval of the infected graft. The BBCI is a continuous infusion of 0.25% betadine in normal saline at 0.3 mL/kg/h for 48 hours then followed by bacitracin infusion with a concentration of 50,000 units bacitracin/per liter normal saline at 0...
March 2018: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
https://www.readbyqxmd.com/read/29452627/case-series-of-18-patients-with-lower-extremity-wounds-treated-with-a-concentrated-surfactant-based-gel-dressing
#17
Catherine R Ratliff
The purpose of this case series was to assess the performance of a concentrated surfactant-based gel (CSG) dressing on 18 patients in the outpatient setting over 4 weeks. Wounds selected were full thickness, had been presented for greater than 4 weeks, and were located on the lower extremities. Patients were given the CSG dressing and instructed on its use. On follow-up clinic visits, the wound was assessed, measurements were obtained, Pressure Ulcer Scale for Healing (PUSH) Tool scores completed, and satisfaction with the dressing was solicited...
March 2018: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
https://www.readbyqxmd.com/read/29452454/macular-edema-in-childhood-uveitis
#18
Justus G Garweg
BACKGROUND: Pediatric uveitis is associated with a high incidence of severe and frequently permanent visual loss. This article summarizes the current understanding of the disease and the therapeutic options that are available to improve treatment outcomes. METHODS: A Medline search spanning the last 10 years was undertaken using the key terms "pediatric uveitis" or "childhood uveitis" and "macular edema". Articles which appertained to case reports or small case series were excluded from consideration, whereas those in which the opinions of experts were expressed, as well as reviews, were not...
February 16, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29452326/awake-microvascular-decompression-for-trigeminal-neuralgia-concept-and-initial-results
#19
Saleem I Abdulrauf, Jorge F Urquiaga, Ritesh Patel, J Andrew Albers, Varun B Sampat, Meghan Baumer, Eric Marvin, Matthew Pierson, Raquel Kragel, Jodi Walsh
OBJECTIVE: The option of performing MVD under awake anesthesia protocol ("awake" MVD) was examined in this initial series to assess whether intraoperative pain evaluation can identify and mitigate insufficient decompression of the trigeminal nerve, improving surgical outcomes. Additionally, "awake" MVD could expand procedure indications for those with comorbidities that would prohibit general endotracheal anesthesia (GEA). METHODS: An IRB-approved prospective study of 10 consecutive adults who underwent MVD for TN was conducted...
February 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29452274/control-of-thiol-maleimide-reaction-kinetics-in-peg-hydrogel-networks
#20
Lauren E Jansen, Lenny J Negrón-Piñeiro, Sualyneth Galarza, Shelly R Peyton
Michael-type addition reactions are widely used to polymerize biocompatible hydrogels. The thiol-maleimide modality achieves the highest macromer coupling efficiency of the reported Michael-type pairs, but the resulting hydrogel networks are heterogeneous, because polymerization is faster than the individual components can be manually mixed. The reactivity of the thiol dictates the overall reaction speed, which can be slowed in organic solvents and acidic buffers. Since these modifications also reduce the biocompatibility of resulting hydrogels, we investigated a series of biocompatible buffers and crosslinkers to decelerate gelation while maintaining high cell viability...
February 13, 2018: Acta Biomaterialia
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