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https://www.readbyqxmd.com/read/28822947/cell-metabolomics-reveals-the-neurotoxicity-mechanism-of-cadmium-in-pc12-cells
#1
Li Zong, Junpeng Xing, Shu Liu, Zhiqiang Liu, Fengrui Song
The heavy metals such as cadmium (Cd) can induce neurotoxicity. Extensive studies about the effects of Cd on human health have been reported, however, a systematic investigation on the molecular mechanisms of the effects of Cd on central nervous system is still needed. In this paper, the neuronal PC-12 cells were treated with a series of concentrations of CdCl2 for 48h. Then the cytotoxicity was evaluated by MTT (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide) assay. The IC15 value (15% inhibiting concentration) was selected for further mechanism studies...
August 17, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28822895/gut-microbiota-trajectory-in-patients-with-severe-burn-a-time-series-study
#2
Xinying Wang, Jianbo Yang, Feng Tian, Li Zhang, Qiucheng Lei, Tingting Jiang, Jihong Zhou, Siming Yuan, Jun Wang, Zhijian Feng, Jieshou Li
PURPOSE: This time series experiments aimed to investigate the dynamic change of gut microbiomes after severe burn and its association with enteral nutrition (EN). MATERIALS AND METHODS: Seven severely burned patients who suffered from a severe metal dust explosion injury were recruited in this study. The dynamic changes of gut microbiome of fecal samples at six time points (1-3days, 2, 3, 4, 5 and 6weeks after severe burn) were detected using 16S ribosomal RNA pyrosequencing technology...
August 12, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28822851/-why-are-we-not-doing-more-for-them-genocide-prevention-lessons-from-the-kindertransport
#3
J Angel, D P Evans
OBJECTIVES: Genocide remains one of the most widespread forms of preventable mortality and morbidity for children today. Despite the creation of multiple human rights treaties, genocide has not been eliminated and its effects disproportionally impact children. The Kindertransport was a series of rescue efforts that brought thousands of refugee children to the United Kingdom from Nazi Germany between 1938 and 1940. This qualitative study asks what public health professionals can learn from the prevention efforts of the Kindertransport by examining the experiences and reflections of individuals rescued as children...
August 17, 2017: Public Health
https://www.readbyqxmd.com/read/28822810/post-stress-metabolic-trajectories-in-young-and-old-flies
#4
Hervé Colinet, David Renault
Hallmarks of aging and age-related mortality (actuarial senescence) have received major focus in the published literature, while fewer studies have investigated functional senescence. Age-related decline in the performance of organism is particularly important for organisms exposed to environmental stress, as the range of conditions allowing physiological equilibria narrows with age (homeostenosis concept). During aging, compensatory metabolic responses might occur to maintain the redox potential and homeostasis...
August 16, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28822735/-the-care-of-skin-lesions-caused-by-extravasation-of-intravenous-fluids-in-peripheral-venous-perfusion
#5
C Ly
INTRODUCTION: Infiltration and extravasation account for 23-78 % of the complications stemming from peripheral venous perfusions in neonatal intensive care units. Their consequences, sometimes dramatic, can be pain, infections, or even loss of skin, which can lead to nerve and/or muscle damage, particularly severe for preterm neonates. Today there are no recommendations on the care of these lesions, which can lead to an erroneous choice or to a delay in the possible treatments. OBJECTIVE: This review of the literature aims to explore and propose elements of therapeutic care collected in the scientific literature...
August 16, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28822645/diphtheria-vaccine-who-position-paper-august-2017-recommendations
#6
World Health Organization
This article presents the World Health Organization's (WHO) recommendations on the use of diphtheria vaccines excerpted from the Diphtheria vaccines: WHO position paper, August 2017, published in the Weekly Epidemiological Record (Diphtheria vaccine, 2017) [1]. This position paper replaces the 2006 WHO position paper on diphtheria vaccine (Diphtheria vaccine, 2006) [2]. The position paper incorporates recent evidence on diphtheria and provides revised recommendations on the optimal number of doses and timing of diphtheria vaccination...
August 16, 2017: Vaccine
https://www.readbyqxmd.com/read/28822641/clinical-and-radiographic-outcomes-with-assessment-of-the-learning-curve-in-arthroscopically-assisted-latissimus-dorsi-tendon-transfer-for-irreparable-posterosuperior-rotator-cuff-tears
#7
Kotaro Yamakado
PURPOSE: To evaluate the clinical results of an arthroscopy-assisted latissimus dorsi tendon transfer (aLD) for irreparable posterosuperior cuff tears as a primary surgery. The secondary aim of this study was to quantify the learning curve using the log-linear model. We hypothesized that aLD significantly improved shoulder function and that there was consistent reduction of the operative time in support of a learning-curve effect. METHODS: After the arthroscopic partial repair was completed, the latissimus dorsi tendon was harvested via axillary mini-open incision and fixed with a knotless anchor arthroscopically...
August 16, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28822636/endoscopic-treatment-of-mid-portion-achilles-tendinopathy-a-retrospective-case-series-of-patient-satisfaction-and-functional-outcome-at-a-2-to-8-year-follow-up
#8
Kim T M Opdam, Thomas P A Baltes, Ruben Zwiers, Jan Joost I Wiegerinck, C Niek van Dijk
PURPOSE: To evaluate the results of endoscopic treatment in patients affected by mid-portion Achilles tendinopathy, by release of the paratenon combined with a resection of the plantaris tendon, regarding patient satisfaction, functional outcome, and pain scores. METHODS: This retrospective study evaluated patients endoscopically treated for mid-portion Achilles tendinopathy between 2000 and 2013. Patient satisfaction, functional outcome, pain scores, and health-related quality of life were measured by the use of a numeric rating scale, the Foot and Ankle Outcome Score, the Victorian Institute of Sport assessment for the Achilles tendon, the numeric rating scale for pain during running and during sports, and the EuroQol 5D (EQ-5D-3L) standardized questionnaire...
August 16, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28822435/-characteristics-of-the-chinese-human-milk-banks-operation
#9
(no author information available yet)
Objective: To assess the operation status of human milk banks in the mainland of China. Method: This retrospective study included a consecutive series of 14 human milk banks in the mainland of China from March 2013 to December 2016. The opened date, condition of donated breast milk, characteristics of donors and clinical application of donated breast milk were analyzed. Result: There were 14 human milk banks successively founded in mainland China from March 2013 to December 2016. The number of human milk banks, the amount of donated breast milk, the number of eligible donors and the times of donation had increased each year...
August 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28822315/applications-of-radon-and-radium-isotopes-to-determine-submarine-groundwater-discharge-and-flushing-times-in-todos-os-santos-bay-brazil
#10
Vanessa Hatje, Karina Kammer Attisano, Marcelo Friederichs Landim de Souza, Barbara Mazzilli, Joselene de Oliveira, Tamires de Araújo Mora, William C Burnett
Todos os Santos Bay (BTS) is the 2nd largest bay in Brazil and an important resource for the people of the State of Bahia. We made measurements of radon and radium in selected areas of the bay to evaluate if these tracers could provide estimates of submarine groundwater discharge (SGD) and flushing times of the Paraguaçu Estuary and BTS. We found that there were a few areas along the eastern and northeastern shorelines that displayed relatively high radon and low salinities, indicating possible sites of enhanced SGD...
August 16, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28822259/ambient-air-pollution-temperature-and-kawasaki-disease-in-shanghai-china
#11
Zhijing Lin, Xia Meng, Renjie Chen, Guoying Huang, Xiaojing Ma, Jingjing Chen, Min Huang, Meirong Huang, Yonghao Gui, Chen Chu, Fang Liu, Haidong Kan
Kawasaki disease (KD) is a kind of pediatric vasculitis of unknown etiology which mainly affects the development of coronary artery aneurysms. Few studies have explored the potential environmental risk factors on KD incidence. We performed a time-series analysis to investigate the associations between air pollution and temperature and KD in Shanghai, China. We collected daily-hospitalized KD patients that were admitted in major pediatric specialty hospitals located in the urban areas of Shanghai from 2001 to 2010...
August 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28822163/-mechanism-of-treatment-effect-of-huanglian-huangqin-herb-pairs-on-cerebral-ischemia-rats-based-on-metabolomic-approach
#12
Hui-Ting Cao, Hua-Xu Zhu, Qi-Chun Zhang, Li-Wei Guo
The metabolic effect of Huanglian-Huangqin herb pairs on cerebral ischemia rats was studied by using metabolomic method. The rat model of ischemia reperfusion injury induced by introduction of transient middle cerebral artery occlusion (MCAO) followed by reperfusion. Ultra high performance liquid chromatography-series four pole time of flight mass spectrometry method(UPLC-Q-TOF/MS), Markerlynx software, and principal component analysis and partial least-squares discriminant analysis were used to analyze the different endogenous metabolites among the urine samples of sham rats, cerebral ischemia model rats, Huanglian groups (HL), Huangqin groups (HQ) and Huanglian-Huangqin herb pairs groups (LQ) was achieved, combined with accurate information about the endogenous metabolites level and secondary fragment ions, retrieval and identification of possible biological markers, metabolic pathway which build in MetPA database...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28821988/presentation-and-management-of-symptomatic-central-bone-cement-embolization
#13
Ahmed Samir Barakat, Tamer Owais, Mohamed Alhashash, Mootaz Shousha, Hesham El Saghir, Bernward Lauer, Heinrich Boehm
BACKGROUND CONTEXT: With more cement augmentation procedures done, the occurrence of serious complications is also expected to rise. Symptomatic central cement embolization is a rare but very serious complication. Moreover, the pathophysiology and treatment of intrathoracic cement embolism remain controversial. PURPOSE: In this case series, we are trying to identify various presentations and suggest our emergent management scheme for symptomatic central cement embolization...
August 18, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28821949/electromagnetically-navigated-in-situ-fenestration-of-aortic-stent-grafts-pilot-animal-study-of-a-novel-fenestrated-evar-approach
#14
Tobias Penzkofer, Hong-Sik Na, Peter Isfort, Christoph Wilkmann, Sabine Osterhues, Andreas Besting, Christoph Hänisch, Stefan Bisplinghoff, Johannes Jansing, Sylvie von Werder, Jorge Gooding, Mathias de la Fuente, Andreas H Mahnken, Catherine Disselhorst-Klug, Thomas Schmitz-Rode, Christiane Kuhl, Philipp Bruners
PURPOSE: Assess electromagnetically guided in situ fenestration of juxtarenal aortic stent grafts in an in vivo model. METHODS: Using a newly developed electromagnetic guidance system together with a modified, electromagnetically guidable catheter with steerable tip, an electromagnetically trackable guidewire and a custom in situ fenestrateable stent graft, a series of seven animal experiments was performed. In a swine model, stent grafts were placed juxtarenally, covering the renal arteries...
August 18, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28821842/direct-learning-hidden-excited-state-interaction-patterns-from-ab-initio-dynamics-and-its-implication-as-alternative-molecular-mechanism-models
#15
Fang Liu, Likai Du, Dongju Zhang, Jun Gao
The excited states of polyatomic systems are rather complex, and often exhibit meta-stable dynamical behaviors. Static analysis of reaction pathway often fails to sufficiently characterize excited state motions due to their highly non-equilibrium nature. Here, we proposed a time series guided clustering algorithm to generate most relevant meta-stable patterns directly from ab initio dynamic trajectories. Based on the knowledge of these meta-stable patterns, we suggested an interpolation scheme with only a concrete and finite set of known patterns to accurately predict the ground and excited state properties of the entire dynamics trajectories, namely, the prediction with ensemble models (PEM)...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821736/ecological-speciation-in-a-generalist-consumer-expands-the-trophic-niche-of-a-dominant-predator
#16
Stephen M Thomas, Chris Harrod, Brian Hayden, Tommi Malinen, Kimmo K Kahilainen
Ecological speciation - whereby an ancestral founder species diversifies to fill vacant niches - is a phenomenon characteristic of newly formed ecosystems. Despite such ubiquity, ecosystem-level effects of such divergence remain poorly understood. Here, we compared the trophic niche of European whitefish (Coregonus lavaretus) and their predators in a series of contrasting subarctic lakes where this species had either diversified into four ecomorphologically distinct morphs or instead formed monomorphic populations...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821564/sox15-regulates-proliferation-and-migration-of-endometrial-cancer-cells
#17
Xiaohui Rui, Yun Xu, Xiping Jiang, Caixia Guo, Jingting Jiang
The study aimed to investigate the effects of SOX15 on proliferation and migration of endometrial cancer (EC) cells. Immunohistochemistry was applied to determine the expression of SOX15 in EC tissues and adjacent tissues. We used cell transfection method to construct the HEC-1-A and Ishikawa cell lines with stable overexpression and low-expression SOX15 Reverse transcription quantitative real-time PCR (RT-qPCR) and western blot were performed to examine expression of SOX15 mRNA and SOX15 protein respectively...
August 18, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28821462/ferritin-nanocage-with-intrinsically-disordered-proteins-and-affibody-a-platform-for-tumor-targeting-with-extended-pharmacokinetics
#18
Na Kyeong Lee, Eun Jung Lee, Soyoun Kim, Gi-Hoon Nam, Minwoo Kih, Yeonsun Hong, Cherlhyun Jeong, Yoosoo Yang, Youngro Byun, In-San Kim
Ferritin nanocages are of particular interest as a novel platform for drug and vaccine delivery, diagnosis, biomineralization scaffold and more, due to their perfect and complex symmetry, ideal physical properties, high biocompatibility, low toxicity profiles as well as easy manipulation by genetic or chemical strategies. However, a short half-life is still a hurdle for the translation of ferritin-based nanomedicines into the clinic. Here, we developed a series of rationally designed long circulating ferritin nanocages (LCFNs) with 'Intrinsically Disordered Proteins (IDP)' as a stealth layer for extending the half-life of ferritin nanocages...
August 15, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28821254/seasonal-fluctuations-in-body-weight-during-growth-of-thoroughbred-racehorses-during-their-athletic-career
#19
Yuji Takahashi, Toshiyuki Takahashi
BACKGROUND: Domesticated horses adapt to environmental conditions through seasonal fluctuations in their metabolic rate. The seasonal change of metabolic rates of domesticated horses in pastures is documented. However, there are few investigations on seasonal body weight change of domesticated horses housed in stables, which are provided constant energy intake throughout the year. Both seasonal changes and gain in body weight of racehorses during their athletic career is known to a lesser extent because their body weight are not measured in most countries...
August 18, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28821212/characterization-of-syntrophic-geobacter-communities-using-tof-sims
#20
Wenchao Wei, Yanyan Zhang, Rachel Komorek, Andrew Plymale, Rujia Yu, Bingchen Wang, Zihua Zhu, Fanghua Liu, Xiao-Ying Yu
The aggregation of syntrophic Geobacter metallireducens and Geobacter sulfurreducens is beneficial for enhancing direct interspecies electron transfer (DIET). Although DIET was suspected to occur on the microbial community surface, the surface chemical speciation of such cocultured communities remains unclear. In order to better understand surface interactions related to DIET, the authors characterized a series of samples associated with syntrophic G. metallireducens and G. sulfurreducens using surface sensitive time-of-flight secondary ion mass spectrometry (ToF-SIMS)...
August 18, 2017: Biointerphases
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